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Conserved domains on  [gi|123784928|sp|Q3UP44|]
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RecName: Full=NHL-repeat-containing protein 4

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins; NHL is a six-bladed beta-propeller

CATH:  2.40.10.500
Gene Ontology:  GO:0005515
PubMed:  9868369|17979191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 16-130 1.28e-21

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14961:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 273  Bit Score: 86.95  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  16 GLEGPCWVGPGPDGGFAVSEEFGD---------VQLFGSAHQPLGSLGTLtGHNFGHP-----AGVCSDAEGSIIVADEQ 81
Cdd:cd14961  143 QLCRPRFVAVSRLGAVAVTEHLFAngtrssstrVKVFSSGGQLLGQIDSF-GLNLVFPslicaSGVAFDSEGNVIVADTG 221

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 123784928  82 RHQVTLFPRVGP-PICLQL--EGLKRPLGMACAPQGQLVVADAGDNCIKLYQ 130
Cdd:cd14961  222 SGAILCLGKPEGfPILKPIvtQGLSRPVGLAVTPDGSLVVLDSGNHCVKIYK 273
 
Name Accession Description Interval E-value
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 16-130 1.28e-21

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 86.95  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  16 GLEGPCWVGPGPDGGFAVSEEFGD---------VQLFGSAHQPLGSLGTLtGHNFGHP-----AGVCSDAEGSIIVADEQ 81
Cdd:cd14961  143 QLCRPRFVAVSRLGAVAVTEHLFAngtrssstrVKVFSSGGQLLGQIDSF-GLNLVFPslicaSGVAFDSEGNVIVADTG 221

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 123784928  82 RHQVTLFPRVGP-PICLQL--EGLKRPLGMACAPQGQLVVADAGDNCIKLYQ 130
Cdd:cd14961  222 SGAILCLGKPEGfPILKPIvtQGLSRPVGLAVTPDGSLVVLDSGNHCVKIYK 273
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 61-128 3.40e-04

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 39.06  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928   61 FGHPAGVCSDAEGSIIVADEQRHQVTLF-PRVGPPICLQLEG-------------LKRPLGMACAPQGQLVVADAGDNCI 126
Cdd:PLN02919  803 LQHPLGVLCAKDGQIYVADSYNHKIKKLdPATKRVTTLAGTGkagfkdgkalkaqLSEPAGLALGENGRLFVADTNNSLI 882


                  ..
gi 123784928  127 KL 128
Cdd:PLN02919  883 RY 884
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 61-88 2.23e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 33.53  E-value: 2.23e-03
                          10        20
                  ....*....|....*....|....*...
gi 123784928   61 FGHPAGVCSDAEGSIIVADEQRHQVTLF 88
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
19-126 4.23e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 35.77  E-value: 4.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  19 GPCWVGPGPDGGFAVSEEFGDvqlfgsahqPLGSL----GTLTGHNFG---HPAGVCSDAEGSIIVADEQRHQ------- 84
Cdd:COG4257   18 GPRDVAVDPDGAVWFTDQGGG---------RIGRLdpatGEFTEYPLGggsGPHGIAVDPDGNLWFTDNGNNRigridpk 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 123784928  85 ---VTLFPrvGPPiclqleGLKRPLGMACAPQGQLVVADAGDNCI 126
Cdd:COG4257   89 tgeITTFA--LPG------GGSNPHGIAFDPDGNLWFTDQGGNRI 125
 
Name Accession Description Interval E-value
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 16-130 1.28e-21

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 86.95  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  16 GLEGPCWVGPGPDGGFAVSEEFGD---------VQLFGSAHQPLGSLGTLtGHNFGHP-----AGVCSDAEGSIIVADEQ 81
Cdd:cd14961  143 QLCRPRFVAVSRLGAVAVTEHLFAngtrssstrVKVFSSGGQLLGQIDSF-GLNLVFPslicaSGVAFDSEGNVIVADTG 221

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 123784928  82 RHQVTLFPRVGP-PICLQL--EGLKRPLGMACAPQGQLVVADAGDNCIKLYQ 130
Cdd:cd14961  222 SGAILCLGKPEGfPILKPIvtQGLSRPVGLAVTPDGSLVVLDSGNHCVKIYK 273
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 16-129 3.49e-12

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 61.57  E-value: 3.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  16 GLEGPCWVGPGPDGGFAVSEEFGD-VQLFGSAHQPLGSLGT--LTGHNFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVG 92
Cdd:cd05819  147 QFNGPTGVAVDSDGNIYVADTGNHrIQVFDPDGNFLTTFGStgTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDG 226

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 123784928  93 PPIC------LQLEGLKRPLGMACAPQGQLVVADAGDNCIKLY 129
Cdd:cd05819  227 AGFGgngnflGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 16-129 4.00e-12

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 61.41  E-value: 4.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  16 GLEGPCWVGPGPDGGFAVSEeFGD--VQLFGSAHQPL---GSLGTLtGHNFGHPAGVCSDAEGSIIVADEQRHQVTLFPR 90
Cdd:cd14954  163 QLDSPRGVAVNPDGNIVVSD-FNNhrLQVFDPDGQFLrffGSEGSG-NGQFKRPRGVAVDDEGNIIVADSGNHRVQVFSP 240

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 123784928  91 VGPPICL------QLEGLKRPLGMACAPQGQLVVADAGDNCIKLY 129
Cdd:cd14954  241 DGEFLCSfgtegnGEGQFDRPSGVAVTPDGRIVVVDRGNHRIQVF 285
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 40-135 3.38e-11

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 58.71  E-value: 3.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  40 VQLFGSAHQPL---GSLGTLTGHnFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPI-CLQLEG-----LKRPLGMAC 110
Cdd:cd14954  141 VQVFDSDGQFIrkfGFEGAGPGQ-LDSPRGVAVNPDGNIVVSDFNNHRLQVFDPDGQFLrFFGSEGsgngqFKRPRGVAV 219

                         90       100
                 ....*....|....*....|....*
gi 123784928 111 APQGQLVVADAGDNCIKLYQYLGEM 135
Cdd:cd14954  220 DDEGNIIVADSGNHRVQVFSPDGEF 244
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 17-129 2.34e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 53.48  E-value: 2.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  17 LEGPCWVGPGPDGGFAVSEEFGD-VQLFGSAHQPLGSLGTLTGHN--FGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGP 93
Cdd:cd05819    7 LNNPQGIAVDSSGNIYVADTGNNrIQVFDPDGNFITSFGSFGSGDgqFNEPAGVAVDSDGNLYVADTGNHRIQKFDPDGN 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 123784928  94 PIC------LQLEGLKRPLGMACAPQGQLVVADAGDNCIKLY 129
Cdd:cd05819   87 FLAsfggsgDGDGEFNGPRGIAVDSSGNIYVADTGNHRIQKF 128
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 17-134 2.46e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 53.48  E-value: 2.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  17 LEGPCWVGPGPDGGFAVSEEFGD-VQLFGSAHQPLGSLGTL--TGHNFGHPAGVCSDAEGSIIVADEQRHQV-------- 85
Cdd:cd05819   54 FNEPAGVAVDSDGNLYVADTGNHrIQKFDPDGNFLASFGGSgdGDGEFNGPRGIAVDSSGNIYVADTGNHRIqkfdpdge 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 123784928  86 --TLFPRVGPPIClqleGLKRPLGMACAPQGQLVVADAGDNCIKLYQYLGE 134
Cdd:cd05819  134 flTTFGSGGSGPG----QFNGPTGVAVDSDGNIYVADTGNHRIQVFDPDGN 180
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 54-127 1.03e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 51.94  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  54 GTLTGhNFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPICLQ------LEGLKRPLGMACAPQGQLVVADAGDNCIK 127
Cdd:cd05819    1 GTGPG-ELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGNFITSFgsfgsgDGQFNEPAGVAVDSDGNLYVADTGNHRIQ 79
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 40-128 2.84e-08

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 50.62  E-value: 2.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  40 VQLFGSAHQPL---GSLGTLTGhNFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPIC------LQLEGLKRPLGMAC 110
Cdd:cd14954   94 IQVFDLNGRFLlkfGERGTKNG-QFNYPWGVAVDSEGRIYVSDTRNHRVQVFDSDGQFIRkfgfegAGPGQLDSPRGVAV 172

                         90
                 ....*....|....*...
gi 123784928 111 APQGQLVVADAGDNCIKL 128
Cdd:cd14954  173 NPDGNIVVSDFNNHRLQV 190
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 40-130 7.99e-08

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 49.47  E-value: 7.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  40 VQLF---GSAHQPLGSLGTLTGHnFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPIC-LQLEG-----LKRPLGMAC 110
Cdd:cd14954   47 VQVFdpdGKFLRKFGSYGSRDGQ-FDRPAGVAVNSRGRIIVADKDNHRIQVFDLNGRFLLkFGERGtkngqFNYPWGVAV 125

                         90       100
                 ....*....|....*....|
gi 123784928 111 APQGQLVVADAGDNCIKLYQ 130
Cdd:cd14954  126 DSEGRIYVSDTRNHRVQVFD 145
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 51-134 1.01e-07

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 49.20  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  51 GSLGTLTGHnFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGP------PICLQLEGLKRPLGMACAPQGQLVVADAGDN 124
Cdd:cd14961    1 GSFGGWPGT-LNNPTGVAVTPTGRVVVADDGNKRIQVFDSDGNclqqfgPKGDAGQDIRYPLDVAVTPDGHIVVTDAGDR 79

                         90
                 ....*....|
gi 123784928 125 CIKLYQYLGE 134
Cdd:cd14961   80 SVKVFSFDGR 89
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 51-132 1.61e-07

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 48.50  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  51 GSLGTLTGHnFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPICLQ---LEGLKRPLGMACAPQGQLVVADAGDNCIK 127
Cdd:cd14960  190 GSNGEGNGQ-FNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYIntsADPLYGPQGLALTSDGHVVVADSGNHCFK 268


                 ....*
gi 123784928 128 LYQYL 132
Cdd:cd14960  269 VYRYL 273
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 50-124 2.61e-06

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 44.85  E-value: 2.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  50 LGSLGTLTGhNFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPICL-----QLEG-LKRPLGMACAPQGQLVVADAGD 123
Cdd:cd14954   13 FGKEGSKDG-ELCRPWGVAVDKDGRIIVADRSNNRVQVFDPDGKFLRKfgsygSRDGqFDRPAGVAVNSRGRIIVADKDN 91


                 .
gi 123784928 124 N 124
Cdd:cd14954   92 H 92
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 60-129 3.97e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 44.50  E-value: 3.97e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123784928  60 NFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPICL--QLEGLKRPLGMACAPQGQLV-VADAGDNCIKLY 129
Cdd:cd14962   55 RFVSPIGVAIDANGNLYVSDAELGKVFVFDRDGKFLRAigAGALFKRPTGIAVDPAGKRLyVVDTLAHKVKVF 127
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 23-124 1.19e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.04  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  23 VGPGPDGGFAVSEEFGD-VQLFGSAHQPL---GSLGTLTGhNFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGppICLQ 98
Cdd:cd14956  159 VAVDPDGTLYVADTYNDrIQVFDNDGAFLrkwGGRGTGPG-QFNYPYGIAIDPDGNVFVADFGNNRIQKFTADG--TFLT 235

                         90       100       110
                 ....*....|....*....|....*....|....
gi 123784928  99 LEG--------LKRPLGMACAPQGQLVVADAGDN 124
Cdd:cd14956  236 SWGspgtgpgqFKNPWGVVVDADGTVYVADSNNN 269
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 49-134 5.70e-05

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 41.11  E-value: 5.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  49 PLGSLGTLTGH--NFGHPAGVCSDAEGSIIVADE--------QRHQVTLFPRVGPPI--------CLQLEGLKRPLGMAC 110
Cdd:cd14961  130 KLGILKKGQKLcsQLCRPRFVAVSRLGAVAVTEHlfangtrsSSTRVKVFSSGGQLLgqidsfglNLVFPSLICASGVAF 209

                         90       100
                 ....*....|....*....|....
gi 123784928 111 APQGQLVVADAGDNCIKLYQYLGE 134
Cdd:cd14961  210 DSEGNVIVADTGSGAILCLGKPEG 233
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 63-124 6.32e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.04  E-value: 6.32e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123784928  63 HPAGVCSDAEGSIIVADEQRHQVT-LFPRVGPPICLQLEGLKRPLGMACAPQGQLVVADAGDN 124
Cdd:cd14952  179 SPSGVAVDTAGNVYVTDHGNNRVLkLAAGSTTPTVLPFTGLNGPLGVAVDAAGNVYVADRGND 241
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 63-124 9.39e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.27  E-value: 9.39e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123784928  63 HPAGVCSDAEGSIIVADEQRHQV-TLFPRVGPPICLQLEGLKRPLGMACAPQGQLVVADAGDN 124
Cdd:cd14952   53 QPQGVAVDAAGTVYVTDFGNNRVlKLAAGSTTQTVLPFTGLNDPTGVAVDAAGNVYVADTGNN 115
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 40-126 1.46e-04

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 39.95  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  40 VQLF---GSAHQPLGSLGTLtGHNFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGppiCLQL---EGLKRPLGMACAPQ 113
Cdd:cd14961   34 IQVFdsdGNCLQQFGPKGDA-GQDIRYPLDVAVTPDGHIVVTDAGDRSVKVFSFDG---RLKLfvrKSFSLPWGVAVNPS 109

                         90
                 ....*....|...
gi 123784928 114 GQLVVADAGDNCI 126
Cdd:cd14961  110 GEILVTDSEAGKL 122
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 26-129 1.53e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 39.96  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  26 GPDGGFAVSEEFGD-VQLFGSAHQPLGSLGTlTGH---NFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPIcLQLEG 101
Cdd:cd14956  115 DADGNLYVADFGNQrIQKFDPDGSFLRQWGG-TGIepgSFNYPRGVAVDPDGTLYVADTYNDRIQVFDNDGAFL-RKWGG 192

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 123784928 102 -------LKRPLGMACAPQGQLVVADAGDNCIKLY 129
Cdd:cd14956  193 rgtgpgqFNYPYGIAIDPDGNVFVADFGNNRIQKF 227
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 64-124 1.66e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 39.88  E-value: 1.66e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 123784928  64 PAGVCSDAEGSIIVADEQRHQV-TLFPRVGPPICLQLEGLKRPLGMACAPQGQLVVADAGDN 124
Cdd:cd14952   96 PTGVAVDAAGNVYVADTGNNRVlKLAAGSNTQTVLPFTGLSNPDGVAVDGAGNVYVTDTGNN 157
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 61-122 1.99e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.49  E-value: 1.99e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123784928  61 FGHPAGVCSDAEGSIIVADEQRHQVTLF-----------PRVGPPiclqlegLKRPLGMACAPQGQLVVADAG 122
Cdd:cd14962   11 LTRPYGVAADGRGRIYVADTGRGAVFVFdlpngkvfvigNAGPNR-------FVSPIGVAIDANGNLYVSDAE 76
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 61-128 3.40e-04

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 39.06  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928   61 FGHPAGVCSDAEGSIIVADEQRHQVTLF-PRVGPPICLQLEG-------------LKRPLGMACAPQGQLVVADAGDNCI 126
Cdd:PLN02919  803 LQHPLGVLCAKDGQIYVADSYNHKIKKLdPATKRVTTLAGTGkagfkdgkalkaqLSEPAGLALGENGRLFVADTNNSLI 882


                  ..
gi 123784928  127 KL 128
Cdd:PLN02919  883 RY 884
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 26-130 6.72e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 38.02  E-value: 6.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  26 GPDGGFAVSEEFGD-VQLFGSAHQPLGSLGTLTGHN--FGHPAGVCSDAEGSIIVADEQRHQVTLF-------PRVGppI 95
Cdd:cd14957  167 DSDGNIYVADTGNHrIQVFTSSGTFQYTFGSSGSGPgqFSDPYGIAVDSDGNIYVADTGNHRIQVFtssgayqYSIG--T 244

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 123784928  96 C-LQLEGLKRPLGMACAPQGQLVVADAGDNCIKLYQ 130
Cdd:cd14957  245 SgSGNGQFNYPYGIAVDNDGKIYVADSNNNRIQVFN 280
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 33-129 8.62e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 37.63  E-value: 8.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  33 VSEEFGD-VQLFGSAHQPLGSLGT-LTGHN-FGHPAGVCSDAEGSIIVADEQRHQVTLFPR------------VGPPicl 97
Cdd:cd14957   33 VADTGNNrIQVFTSSGVYSYSIGSgGTGSGqFNSPYGIAVDSNGNIYVADTDNNRIQVFNSsgvyqysigtggSGDG--- 109

                         90       100       110
                 ....*....|....*....|....*....|..
gi 123784928  98 qleGLKRPLGMACAPQGQLVVADAGDNCIKLY 129
Cdd:cd14957  110 ---QFNGPYGIAVDSNGNIYVADTGNHRIQVF 138
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 27-129 1.01e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 37.65  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  27 PDGGFAVSEEFGD-VQLFGSAHQPL---GSLGTLTGHnFGHPAGVCSDAEGSIIVAD--EQRHQ--------VTLFPRVG 92
Cdd:cd14956   69 KDGWLYVADYWGDrIQVFTLTGELQtigGSSGSGPGQ-FNAPRGVAVDADGNLYVADfgNQRIQkfdpdgsfLRQWGGTG 147

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 123784928  93 PPiclqLEGLKRPLGMACAPQGQLVVADAGDNCIKLY 129
Cdd:cd14956  148 IE----PGSFNYPRGVAVDPDGTLYVADTYNDRIQVF 180
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 51-93 1.43e-03

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 37.25  E-value: 1.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 123784928  51 GSLGTLTGHnFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGP 93
Cdd:cd14959   12 GESGSGEGQ-FNSPSGFCLGEDEDILVADTNNHRIQVFDKEGE 53
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 26-129 1.54e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 37.18  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  26 GPDGGFAVSE-EFGDVQLFGSAHQPLGSLGTltGHNFGHPAGVCSDAEGS-IIVADEQRHQVTLFPRVGppiclQLEG-- 101
Cdd:cd14962   65 DANGNLYVSDaELGKVFVFDRDGKFLRAIGA--GALFKRPTGIAVDPAGKrLYVVDTLAHKVKVFDLDG-----RLLFdi 137

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 123784928 102 ---------LKRPLGMACAPQGQLVVADAGDNCIKLY 129
Cdd:cd14962  138 gkrgsgpgeFNLPTDLAVDRDGNLYVTDTMNFRVQIF 174
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 51-126 1.64e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 36.79  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  51 GSLGTLTGhNFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPICL---------QlegLKRPLGMACAPQGQLVVADA 121
Cdd:cd14955    6 GSYGSGDG-QFNSPSGIAVDSAGNVYVADTGNNRIQKFDSTGTFLTKwgssgsgdgQ---FYSPTGIAVDSDGNVYVADT 81


                 ....*
gi 123784928 122 GDNCI 126
Cdd:cd14955   82 GNHRI 86
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 61-88 2.23e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 33.53  E-value: 2.23e-03
                          10        20
                  ....*....|....*....|....*...
gi 123784928   61 FGHPAGVCSDAEGSIIVADEQRHQVTLF 88
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 40-126 2.45e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 36.40  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  40 VQLFGSAHQPL---GSLGTLTGHnFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPICL-QLEG-----LKRPLGMAC 110
Cdd:cd14955  133 IQKFDSSGTFItkwGSFGSGDGQ-FNSPTGIAVDSAGNVYVADTGNNRIQKFTSTGTFLTKwGSEGsgdgqFNAPYGIAV 211

                         90
                 ....*....|....*.
gi 123784928 111 APQGQLVVADAGDNCI 126
Cdd:cd14955  212 DSAGNVYVADTGNNRI 227
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 40-126 2.78e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 36.40  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  40 VQLFGSAHQPLGSLGTLTGHN--FGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPIC-----LQLEGLK-RPLGMACA 111
Cdd:cd14955  180 IQKFTSTGTFLTKWGSEGSGDgqFNAPYGIAVDSAGNVYVADTGNNRIQKFDSSGTFITkwgseGSGDGQFnSPSGIAVD 259

                         90
                 ....*....|....*
gi 123784928 112 PQGQLVVADAGDNCI 126
Cdd:cd14955  260 SAGNVYVADSGNNRI 274
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 17-88 2.82e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 36.09  E-value: 2.82e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 123784928  17 LEGPCWVGPGPDGGFAVSEEFGD-VQLFGSAHQPL---GSLGTLTGHnFGHPAGVCSDAEGSIIVADEQRHQVTLF 88
Cdd:cd14957  111 FNGPYGIAVDSNGNIYVADTGNHrIQVFTSSGTFSysiGSGGTGPGQ-FNGPQGIAVDSDGNIYVADTGNHRIQVF 185
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
19-126 4.23e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 35.77  E-value: 4.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  19 GPCWVGPGPDGGFAVSEEFGDvqlfgsahqPLGSL----GTLTGHNFG---HPAGVCSDAEGSIIVADEQRHQ------- 84
Cdd:COG4257   18 GPRDVAVDPDGAVWFTDQGGG---------RIGRLdpatGEFTEYPLGggsGPHGIAVDPDGNLWFTDNGNNRigridpk 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 123784928  85 ---VTLFPrvGPPiclqleGLKRPLGMACAPQGQLVVADAGDNCI 126
Cdd:COG4257   89 tgeITTFA--LPG------GGSNPHGIAFDPDGNLWFTDQGGNRI 125
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 51-129 6.13e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 35.34  E-value: 6.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  51 GSLGTLTGHnFGHPAGVCSDAEGSIIVADEQRHQVTLFPRVGPPIcLQL-------EGLKRPLGMACAPQGQLVVADAGD 123
Cdd:cd14956    3 GGRGSGPGQ-FKDPRGIAVDADDNVYVADARNGRIQVFDKDGTFL-RRFgttgdgpGQFGRPRGLAVDKDGWLYVADYWG 80


                 ....*.
gi 123784928 124 NCIKLY 129
Cdd:cd14956   81 DRIQVF 86
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 63-124 7.52e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 34.88  E-value: 7.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123784928  63 HPAGVCSDAEGSIIVADEQRHQV-TLFPRVGPPICLQLEGLKRPLGMACAPQGQLVVADAGDN 124
Cdd:cd14952   11 GPGGVAVDAAGNVYVADSGNNRVlKLAAGSTTQTVLPFTGLYQPQGVAVDAAGTVYVTDFGNN 73
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 20-132 9.73e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 34.87  E-value: 9.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123784928  20 PCWVGPGPDGGFAVSEEF-GDVQLF---GSAHQPLGSLGTLTGhNFGHPAGVCSDAEGSIIVADEQRHQVTLF------- 88
Cdd:cd14962  150 PTDLAVDRDGNLYVTDTMnFRVQIFdadGKFLRSFGERGDGPG-SFARPKGIAVDSEGNIYVVDAAFDNVQIFnpegell 228

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 123784928  89 -----PRVGPPiclqleGLKRPLGMACAPQGQLVVADAGDNCIKLYQYL 132
Cdd:cd14962  229 ltvggPGSGPG------EFYLPSGIAIDKDDRIYVVDQFNRRIQVFQYL 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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