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Conserved domains on  [gi|205785564|sp|Q49VK4|]
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RecName: Full=Sensor histidine kinase GraS; AltName: Full=Glycopeptide resistance-associated protein S

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
15-329 9.92e-42

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 148.13  E-value: 9.92e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  15 IYWILWLLFLHFIFLGIAYLDYDISVYSILYIIILNIGLSVLFLIFTYLKEVKFYKHLDENIEPEALKHKSLADTPFQQE 94
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  95 MVNYLYGQITNQKALVTHQKQQIQSTEAALTDFV----HDIKTPVTAMKL---LIEKEQDLSRKHAL---LYEWSRINDM 164
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLanvsHELRTPLTAIRGyleLLLEELDEEQREYLetiLRSADRLLRL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 165 LDRQLFLTRLEYQNKDMYFEHVPLKRLVIEEIQITRYISQSKGIGYDLDFEDTL-NVYTDTKWCRMMIRQVLSNAVKYSE 243
Cdd:COG0642  161 INDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 244 E-SMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTiSSGLGLYLVNHVKEKLSICVRIHSELDKGT 322
Cdd:COG0642  241 EgGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIVELHGGTIEVESEPGKGT 319


                 ....*..
gi 205785564 323 VVKFIFP 329
Cdd:COG0642  320 TFTVTLP 326
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
15-329 9.92e-42

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 148.13  E-value: 9.92e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  15 IYWILWLLFLHFIFLGIAYLDYDISVYSILYIIILNIGLSVLFLIFTYLKEVKFYKHLDENIEPEALKHKSLADTPFQQE 94
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  95 MVNYLYGQITNQKALVTHQKQQIQSTEAALTDFV----HDIKTPVTAMKL---LIEKEQDLSRKHAL---LYEWSRINDM 164
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLanvsHELRTPLTAIRGyleLLLEELDEEQREYLetiLRSADRLLRL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 165 LDRQLFLTRLEYQNKDMYFEHVPLKRLVIEEIQITRYISQSKGIGYDLDFEDTL-NVYTDTKWCRMMIRQVLSNAVKYSE 243
Cdd:COG0642  161 INDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 244 E-SMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTiSSGLGLYLVNHVKEKLSICVRIHSELDKGT 322
Cdd:COG0642  241 EgGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIVELHGGTIEVESEPGKGT 319


                 ....*..
gi 205785564 323 VVKFIFP 329
Cdd:COG0642  320 TFTVTLP 326
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-329 1.30e-40

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 138.19  E-value: 1.30e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 222 TDTKWCRMMIRQVLSNAVKYS-EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTISSGLGLYL 300
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSkQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                         90       100
                 ....*....|....*....|....*....
gi 205785564 301 VNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 222-329 1.50e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 98.88  E-value: 1.50e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564   222 TDTKWCRMMIRQVLSNAVKYSEE-SMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTISSGLGLYL 300
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEgGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80

                           90       100
                   ....*....|....*....|....*....
gi 205785564   301 VNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 222-329 2.56e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 82.03  E-value: 2.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  222 TDTKWCRMMIRQVLSNAVKYS-EESMIHIRaLKESRHVVLEIKDEGKGISEKDLPRIFDKgFTSTSNRnNTISSGLGLYL 300
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAaKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEP-FSTADKR-GGGGTGLGLSI 77

                          90       100
                  ....*....|....*....|....*....
gi 205785564  301 VNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGGTTVTLTLP 106
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 123-330 1.17e-14

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 74.50  E-value: 1.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 123 ALTdfvHDIKTPVTAMK----LLIEKEQDLSRKHAL---LYEWSRINDMLDRQLFLTRLEYQNKDMYFEHVPLKRLVIE- 194
Cdd:PRK11100 262 TLT---HELKSPLAAIRgaaeLLQEDPPPEDRARFTgniLTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEEl 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 195 ----EIQITRyisqsKGIGYDLDFEDtLNVYTDTKWCRMMIRQVLSNAVKYS-EESMIHIRALKESRHVVLEIKDEGKGI 269
Cdd:PRK11100 339 vearEAQAAA-----KGITLRLRPDD-ARVLGDPFLLRQALGNLLDNAIDFSpEGGTITLSAEVDGEQVALSVEDQGPGI 412

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205785564 270 SEKDLPRIFDKgFTSTSNRNNTI-SSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFPN 330
Cdd:PRK11100 413 PDYALPRIFER-FYSLPRPANGRkSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
15-329 9.92e-42

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 148.13  E-value: 9.92e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  15 IYWILWLLFLHFIFLGIAYLDYDISVYSILYIIILNIGLSVLFLIFTYLKEVKFYKHLDENIEPEALKHKSLADTPFQQE 94
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  95 MVNYLYGQITNQKALVTHQKQQIQSTEAALTDFV----HDIKTPVTAMKL---LIEKEQDLSRKHAL---LYEWSRINDM 164
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLanvsHELRTPLTAIRGyleLLLEELDEEQREYLetiLRSADRLLRL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 165 LDRQLFLTRLEYQNKDMYFEHVPLKRLVIEEIQITRYISQSKGIGYDLDFEDTL-NVYTDTKWCRMMIRQVLSNAVKYSE 243
Cdd:COG0642  161 INDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 244 E-SMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTiSSGLGLYLVNHVKEKLSICVRIHSELDKGT 322
Cdd:COG0642  241 EgGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIVELHGGTIEVESEPGKGT 319


                 ....*..
gi 205785564 323 VVKFIFP 329
Cdd:COG0642  320 TFTVTLP 326
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
112-329 1.70e-41

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 144.66  E-value: 1.70e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 112 HQKQQIQSTEAALTDFV----HDIKTPVTAMKL---LIEKEQDLS----RKHA--LLYEWSRINDMLDRQLFLTRLEYQN 178
Cdd:COG2205    4 EALEELEELERLKSEFLanvsHELRTPLTSILGaaeLLLDEEDLSpeerRELLeiIRESAERLLRLIEDLLDLSRLESGK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 179 KDMYFEHVPLKRLVIEEIQITRYISQSKGIGYDLDF-EDTLNVYTDTKWCRMMIRQVLSNAVKYS-EESMIHIRALKESR 256
Cdd:COG2205   84 LSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLpPELPLVYADPELLEQVLANLLDNAIKYSpPGGTITISARREGD 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205785564 257 HVVLEIKDEGKGISEKDLPRIFDKgFTSTSNRNNTISSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:COG2205  164 GVRISVSDNGPGIPEEELERIFER-FYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-329 1.30e-40

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 138.19  E-value: 1.30e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 222 TDTKWCRMMIRQVLSNAVKYS-EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTISSGLGLYL 300
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSkQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                         90       100
                 ....*....|....*....|....*....
gi 205785564 301 VNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
7-333 3.37e-35

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 131.98  E-value: 3.37e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564   7 FFIFLRSRIYWILWLLFLHFIFLGIAYLDYDISVYSILYIIILNIGLSVLFLIFTYLKEVKFYKHLDENIEPEALKHKSL 86
Cdd:COG5002   48 LLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  87 ADTPFQQEMVNYLYGQITNQKALVTHQKQQIQSTEAALTDFV----HDIKTPVTAMKLLIE--------KEQDLSRKHAL 154
Cdd:COG5002  128 LLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVanvsHELRTPLTSIRGYLEllldgaadDPEERREYLEI 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 155 LYEWSR-----INDMLDrqlfLTRLEYQNKDMYFEHVPLKRLVIEEIQITRYISQSKGIGYDLDFEDT-LNVYTDtkwcR 228
Cdd:COG5002  208 ILEEAErlsrlVNDLLD----LSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpLLVLGD----P 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 229 MMIRQVL----SNAVKYSEE-SMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTIS-SGLGLYLVN 302
Cdd:COG5002  280 DRLEQVLtnllDNAIKYTPEgGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGgTGLGLAIVK 359

                        330       340       350
                 ....*....|....*....|....*....|.
gi 205785564 303 HVKEKLSICVRIHSELDKGTVVKFIFPNQNE 333
Cdd:COG5002  360 HIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 222-329 1.50e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 98.88  E-value: 1.50e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564   222 TDTKWCRMMIRQVLSNAVKYSEE-SMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTISSGLGLYL 300
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEgGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80

                           90       100
                   ....*....|....*....|....*....
gi 205785564   301 VNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLP 109
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 129-329 5.44e-21

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 93.10  E-value: 5.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 129 HDIKTPVTAMKLLIE-----KEQDLSRKHALLYEW--------SRINDMLDRQLFLTRLEYQNkdmyFEHVPLKRLVIEE 195
Cdd:COG5000  210 HEIKNPLTPIQLSAErlrrkLADKLEEDREDLERAldtiirqvDRLKRIVDEFLDFARLPEPQ----LEPVDLNELLREV 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 196 IQITRYISQSKGIGYDLDFEDTL-NVYTDtkwcRMMIRQVLSNAVKYSEESM-----IHIRALKESRHVVLEIKDEGKGI 269
Cdd:COG5000  286 LALYEPALKEKDIRLELDLDPDLpEVLAD----RDQLEQVLINLLKNAIEAIeeggeIEVSTRREDGRVRIEVSDNGPGI 361

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205785564 270 SEKDLPRIFDKGFTSTSNrnntiSSGLGLYLVNHVKEKL--SIcvRIHSELDKGTVVKFIFP 329
Cdd:COG5000  362 PEEVLERIFEPFFTTKPK-----GTGLGLAIVKKIVEEHggTI--ELESRPGGGTTFTIRLP 416
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 222-329 2.56e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 82.03  E-value: 2.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  222 TDTKWCRMMIRQVLSNAVKYS-EESMIHIRaLKESRHVVLEIKDEGKGISEKDLPRIFDKgFTSTSNRnNTISSGLGLYL 300
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAaKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEP-FSTADKR-GGGGTGLGLSI 77

                          90       100
                  ....*....|....*....|....*....
gi 205785564  301 VNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGGTTVTLTLP 106
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 1-333 4.74e-17

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 81.76  E-value: 4.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564   1 MANLKWFFIFLRSRIYWILWLLFLHFIFLGIAYLDYDISVYSILYIIILNIGLSVLFLIFTYLKEVKFYKHLDENIEPEA 80
Cdd:COG4251  159 LLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  81 LKHKSLADTPFQQEMVNYLYGQITNQKALVTHQKQQIQSTEAALTDFV----HDIKTPVTAM----KLLIEKEQDL---- 148
Cdd:COG4251  239 LLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAyvasHDLREPLRKIsgfsQLLEEDYGDKldee 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 149 ------------SRKHALlyewsrINDMLDrqlfLTRLEyqNKDMYFEHVPLKRL---VIEEIQITryISQSkgiGYDLD 213
Cdd:COG4251  319 greylerirdaaERMQAL------IDDLLA----YSRVG--RQELEFEPVDLNELleeVLEDLEPR--IEER---GAEIE 381

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 214 FEDTLNVYTDtkwcRMMIRQV----LSNAVKYSEESM---IHIRALKESRHVVLEIKDEGKGISEKDLPRIFDkGFTSTS 286
Cdd:COG4251  382 VGPLPTVRGD----PTLLRQVfqnlISNAIKYSRPGEpprIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFE-IFQRLH 456

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 205785564 287 NRNNTISSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFPNQNE 333
Cdd:COG4251  457 SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 129-329 5.94e-17

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 80.61  E-value: 5.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 129 HDIKTPVTAMKL---LIEKEQDLSRKHALLYEWS--------RINDMLDRQLFLTRLEyqnkDMYFEHVPLKRLVIEEIQ 197
Cdd:COG4191  151 HEINNPLAAILGnaeLLRRRLEDEPDPEELREALerilegaeRAAEIVRSLRAFSRRD----EEEREPVDLNELIDEALE 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 198 ITRYISQSKGIGYDLDFEDTL-NVYTDtkwcRMMIRQVLSN-------AVKYSEESMIHIRALKESRHVVLEIKDEGKGI 269
Cdd:COG4191  227 LLRPRLKARGIEVELDLPPDLpPVLGD----PGQLEQVLLNllinaidAMEEGEGGRITISTRREGDYVVISVRDNGPGI 302

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 270 SEKDLPRIFDKGFTSTSNRNNTissGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:COG4191  303 PPEVLERIFEPFFTTKPVGKGT---GLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 5-329 5.94e-15

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 75.29  E-value: 5.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564   5 KWFFIFLRSRIYWILWLLFLHFIFLGIA--YLDYDIS--VYSILYIIILNIglsVLFLIFTYLKEvkfykHLDENIEpea 80
Cdd:COG5806  119 KFHRLSRKGKIVLAILLSFLSALLLLLLaiIFIADISelLDFILYFIIIQL---LAMLIAVYLIE-----NLIENIL--- 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  81 LKHKsladtpfqqemvnylygqitnqkaLVTHQKQQIQSTEAAltDFVHDIKTPVTA----MKLLIEKE-QDLSRKHAL- 154
Cdd:COG5806  188 LRKE------------------------LQRAEKLEVVSELAA--SIAHEVRNPLTVvrgfIQLLQEPElSDEKRKQYIr 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 155 --LYEWSRINDMLDRQLFLTRLEYQNKdmyfEHVPLKRLVIEEIQITRYISQSKGIGYDLDFEDTLNVYTDtkwcRMMIR 232
Cdd:COG5806  242 iaLEELDRAEAIITDYLTFAKPQPEKL----EKIDVSEELEHVIDVLSPYANMNNVEIQTELEPGLYIEGD----RQKLQ 313

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 233 QVLSNAVKYSEESM-----IHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTstsnrNNTISSGLGLYLVNHVKEK 307
Cdd:COG5806  314 QCLINIIKNGIEAMpnggtLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFS-----TKEKGTGLGTMVSYRIIEA 388

                        330       340
                 ....*....|....*....|..
gi 205785564 308 LSICVRIHSELDKGTVVKFIFP 329
Cdd:COG5806  389 MNGTIRVESEVGKGTTFTITLP 410
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 123-330 1.17e-14

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 74.50  E-value: 1.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 123 ALTdfvHDIKTPVTAMK----LLIEKEQDLSRKHAL---LYEWSRINDMLDRQLFLTRLEYQNKDMYFEHVPLKRLVIE- 194
Cdd:PRK11100 262 TLT---HELKSPLAAIRgaaeLLQEDPPPEDRARFTgniLTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEEl 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 195 ----EIQITRyisqsKGIGYDLDFEDtLNVYTDTKWCRMMIRQVLSNAVKYS-EESMIHIRALKESRHVVLEIKDEGKGI 269
Cdd:PRK11100 339 vearEAQAAA-----KGITLRLRPDD-ARVLGDPFLLRQALGNLLDNAIDFSpEGGTITLSAEVDGEQVALSVEDQGPGI 412

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205785564 270 SEKDLPRIFDKgFTSTSNRNNTI-SSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFPN 330
Cdd:PRK11100 413 PDYALPRIFER-FYSLPRPANGRkSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 129-329 2.81e-14

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 73.47  E-value: 2.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 129 HDIKTPVTAMK----LLIEKEQDLSRKHA--LLYEWSRINDMLDRQLFLTRleyqNKDMYFEHVPLKRLVIEEIQITRYI 202
Cdd:COG5809  279 HEIRNPLTSLKgfiqLLKDTIDEEQKTYLdiMLSELDRIESIISEFLVLAK----PQAIKYEPKDLNTLIEEVIPLLQPQ 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 203 SQSKGIGYDLDFEDTLN-VYTDTKwcrmMIRQVLSNAVKYSEESM-----IHIRA-LKESRHVVLEIKDEGKGISEKDLP 275
Cdd:COG5809  355 ALLKNVQIELELEDDIPdILGDEN----QLKQVFINLLKNAIEAMpeggnITIETkAEDDDKVVISVTDEGCGIPEERLK 430

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 205785564 276 RIFDKGFTSTSNrnntiSSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:COG5809  431 KLGEPFYTTKEK-----GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
103-329 4.22e-14

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 73.08  E-value: 4.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 103 ITNQKALvthqKQQIQSTE--AALTDFV----HDIKTPVTA----MKLLIEKEQDLSRKHAL---LYEWSRINDMLDRQL 169
Cdd:PRK11360 371 LTERKRL----QRRVARQErlAALGELVagvaHEIRNPLTAirgyVQIWRQQTSDPPSQEYLsvvLREVDRLNKVIDQLL 446

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 170 FLTRleyqNKDMYFEHVPLKRLVIEEIQITRYISQSKGIGYDLDFEDTL-NVYTDtkwcRMMIRQVLSN----AVK-YSE 243
Cdd:PRK11360 447 EFSR----PRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELpPIWAD----PELLKQVLLNilinAVQaISA 518

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 244 ESMIHIRALKES-RHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNrnntiSSGLGLYLVNHVKEKLSICVRIHSELDKGT 322
Cdd:PRK11360 519 RGKIRIRTWQYSdGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK-----GTGLGLALSQRIINAHGGDIEVESEPGVGT 593


                 ....*..
gi 205785564 323 VVKFIFP 329
Cdd:PRK11360 594 TFTLYLP 600
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-329 2.75e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 62.44  E-value: 2.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 228 RMMIRQVLSN-----AVKYSEESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTissGLGLYLVN 302
Cdd:cd16943    1 PSQLNQVLLNllvnaAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGT---GLGLSLSY 77

                         90       100
                 ....*....|....*....|....*..
gi 205785564 303 HVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:cd16943   78 RIIQKHGGTIRVASVPGGGTRFTIILP 104
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 231-329 3.36e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 62.13  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 231 IRQVL----SNAVKYSEESMIHIRALKESR---HVVL--EIKDEGKGISEKDLPRIFDKgFT--STSNRNNTISSGLGly 299
Cdd:cd16922    1 LRQILlnllGNAIKFTEEGEVTLRVSLEEEeedGVQLrfSVEDTGIGIPEEQQARLFEP-FSqaDSSTTRKYGGTGLG-- 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 205785564 300 lvnhvkekLSIC----------VRIHSELDKGTVVKFIFP 329
Cdd:cd16922   78 --------LAISkklvelmggdISVESEPGQGSTFTFTLP 109
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
102-329 3.62e-12

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 66.41  E-value: 3.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 102 QITNQKAL--VTHQKQQIQSTEAALTDFVHDIKTPVTAMK----LLIEKEQDLSRKHAL---LYEWSRINDMLDRQLFLT 172
Cdd:COG3852  115 DITERKRLerELRRAEKLAAVGELAAGLAHEIRNPLTGIRgaaqLLERELPDDELREYTqliIEEADRLNNLVDRLLSFS 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 173 RleyqNKDMYFEHVPLKRlVIEEIqiTRYISQS--KGIGYDLDFEDTL-NVYTDtkwcRMMIRQVLSNAVKYSEESM--- 246
Cdd:COG3852  195 R----PRPPEREPVNLHE-VLERV--LELLRAEapKNIRIVRDYDPSLpEVLGD----PDQLIQVLLNLVRNAAEAMpeg 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 247 --IHIRA----------LKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNrnntiSSGLGLYLVNhvkeklSIC--- 311
Cdd:COG3852  264 gtITIRTrverqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK-----GTGLGLAIVQ------KIVeqh 332

                        250       260
                 ....*....|....*....|.
gi 205785564 312 ---VRIHSELDKGTVVKFIFP 329
Cdd:COG3852  333 ggtIEVESEPGKGTTFRIYLP 353
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 129-329 4.13e-12

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 66.68  E-value: 4.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 129 HDIKTPVTAMK-----LLIEKEQDLSRKHALLYEWSRINDMLDRQLFLTRleyqNKDMYFEHVPLKRLVIEEIQI--TRY 201
Cdd:COG5805  296 HEIRNPLTSIKgflqlLQPGIEDKEEYFDIMLSELDRIESIISEFLALAK----PQAVNKEKENINELIQDVVTLleTEA 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 202 ISQSKGIGYDLdFEDTLNVYTDTKwcrmMIRQVLSNAVKYSEESM-----IHIRALKESRHVVLEIKDEGKGISEKDLPR 276
Cdd:COG5805  372 ILHNIQIRLEL-LDEDPFIYCDEN----QIKQVFINLIKNAIEAMpnggtITIHTEEEDNSVIIRVIDEGIGIPEERLKK 446

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 205785564 277 IFDKGFTSTSNrnntiSSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:COG5805  447 LGEPFFTTKEK-----GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-329 7.51e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 61.45  E-value: 7.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 228 RMMIRQVLSNAVKYS-EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNR-NNTISSGLGLYLVNHVK 305
Cdd:cd16952    2 RSAFSNLVSNAVKYTpPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERcRNTGGTGLGLAIVKHVM 81

                         90       100
                 ....*....|....*....|....
gi 205785564 306 EKLSICVRIHSELDKGTVVKFIFP 329
Cdd:cd16952   82 SRHDARLLIASELGKGSRFTCLFP 105
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 247-333 2.85e-11

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 64.10  E-value: 2.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 247 IHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNntisSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKF 326
Cdd:COG3290  307 VELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLGEG----RGLGLALVKQIVEKYGGTIEVESEEGEGTVFTV 382


                 ....*..
gi 205785564 327 IFPNQNE 333
Cdd:COG3290  383 RLPKEGE 389
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
106-331 3.42e-11

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 63.88  E-value: 3.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 106 QKALVTHQKQQIQSTEAALTDFV----HDIKTPVTAMKLLIE--KEQDL-----SRKHALLYEWSRINDMLDRQLF-LTR 173
Cdd:PRK11006 186 QLLMVARDVTQMHQLEGARRNFFanvsHELRTPLTVLQGYLEmmQDQPLegalrEKALHTMREQTQRMEGLVKQLLtLSK 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 174 LEYQNKDMYFE--HVPLKRLVIEEIQITryISQSK-GIGYDLDfeDTLNVYTDTKWCRMMIRQVLSNAVKYSEE-SMIHI 249
Cdd:PRK11006 266 IEAAPTIDLNEkvDVPMMLRVLEREAQT--LSQGKhTITFEVD--NSLKVFGNEDQLRSAISNLVYNAVNHTPEgTHITV 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 250 RALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRN-NTISSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIF 328
Cdd:PRK11006 342 RWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSrQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVL 421


                 ...
gi 205785564 329 PNQ 331
Cdd:PRK11006 422 PER 424
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
105-314 1.26e-10

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 62.34  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 105 NQKAlVTHQKQQiQSTEAALTDFVHDIKTPVTAMKLLIEKEQDLSRK------HALLYEWSRINDMLD--RQLFLT---R 173
Cdd:PRK10549 227 NQLA-STLEKNE-QMRRDFMADISHELRTPLAVLRGELEAIQDGVRKftpesvASLQAEVGTLTKLVDdlHQLSLSdegA 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 174 LEYQNkdmyfEHVPLKRLVIEEIQITRYISQSKGIGYDLDFEDTLNVYTDTKWCRMMIRQVLSNAVKYSEES-MIHIRAL 252
Cdd:PRK10549 305 LAYRK-----TPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGgSLHISAE 379

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205785564 253 KESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTI-SSGLGlylvnhvkekLSICVRI 314
Cdd:PRK10549 380 QRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASgGSGLG----------LAICLNI 432
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 231-303 4.93e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 56.18  E-value: 4.93e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205785564 231 IRQVLSNAVKYSEESmIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRN-NTISSGLGLYLVNH 303
Cdd:cd16949    5 LENVLRNALRYSPSK-ILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDrESGGTGLGLAIAER 77
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 215-325 1.17e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 55.10  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 215 EDTLNVYTDTKWCRMMIRQVLSNAVKYS-EESMIHIRaLKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSnrNNTIS 293
Cdd:cd16940    2 AADIQVQGDALLLFLLLRNLVDNAVRYSpQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG--QNYGG 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 205785564 294 SGLGLYLVNHVKEKLSICVRIHSELDKGTVVK 325
Cdd:cd16940   79 SGLGLSIVKRIVELHGGQIFLGNAQGGGLEAW 110
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 248-329 3.58e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 53.92  E-value: 3.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 248 HIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTissGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFI 327
Cdd:cd16919   38 NYRDLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGT---GLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIY 114


                 ..
gi 205785564 328 FP 329
Cdd:cd16919  115 LP 116
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 235-329 4.77e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 53.16  E-value: 4.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 235 LSNAVKYS-EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKgFTSTSNRNNTISSGLGLYLVNHVKEKLSICVR 313
Cdd:cd16923    9 LSNAIKYSpENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFER-FYRGDNSRNTEGAGLGLSIAKAIIELHGGSAS 87

                         90
                 ....*....|....*.
gi 205785564 314 IHSElDKGTVVKFIFP 329
Cdd:cd16923   88 AEYD-DNHDLFKVRLP 102
PRK10604 PRK10604
sensor protein RstB; Provisional
 105-302 9.44e-09

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 56.54  E-value: 9.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 105 NQKALVTHQKQqiqsteaaLTDFV-HDIKTPVTAMKLLIEKEQDLS--RKHALLYEWSRINDMLDRQLFLTRLEYQNKDM 181
Cdd:PRK10604 204 NINALIASKKQ--------LIDGIaHELRTPLVRLRYRLEMSDNLSaaESQALNRDIGQLEALIEELLTYARLDRPQNEL 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 182 YFEHVPLKRLVIEEIQITRYISQSKGIgyDLDFEDTLNV-YTDTkwcRMMIRQV---LSNAVKYSEeSMIHIRALKESRH 257
Cdd:PRK10604 276 HLSEPDLPAWLSTHLADIQAVTPEKTV--RLDTPHQGDYgALDM---RLMERVLdnlLNNALRYAH-SRVRVSLLLDGNQ 349

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 205785564 258 VVLEIKDEGKGISEKDLPRIFDKgFT--STSNRNNTISSGLGLYLVN 302
Cdd:PRK10604 350 ACLIVEDDGPGIPPEERERVFEP-FVrlDPSRDRATGGCGLGLAIVH 395
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-329 2.24e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 51.29  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 233 QVL-SNAVKYSEE-----SMIHIRALKESRHVVLEIKDEGKGISEKDLPRifdkgftstSNRNNTISSGLGLYLVNH--- 303
Cdd:cd16924    7 QPLvENAIQHGLSpltdkGVVTISALKEDNHVMIEVEDNGRGIDPKVLNI---------LGKKPKEGNGIGLYNVHQrli 77

                         90       100
                 ....*....|....*....|....*...
gi 205785564 304 --VKEKLSIcvRIHSELDKGTVVKFIFP 329
Cdd:cd16924   78 llFGEDYGI--HIASEPDKGTRITFTIP 103
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 223-304 2.26e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 51.31  E-value: 2.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 223 DTKWCRMMIRQVLSNAVKYSEES-MIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTISSGLGLYLV 301
Cdd:cd16945    1 DPFLLRQAINNLLDNAIDFSPEGgLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFV 80


                 ...
gi 205785564 302 NHV 304
Cdd:cd16945   81 QEV 83
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 212-323 2.70e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 51.75  E-value: 2.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 212 LDFEDTlNVYT--DTKWCRMMIRQVLSNAVKY-SEESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNR 288
Cdd:cd16947    5 INIPDR-PIYAnaNTEALQRILKNLISNAIKYgSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSR 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 205785564 289 NNTIS-SGLGLYLVNHVKEKLSICVRIHSELDKGTV 323
Cdd:cd16947   84 NSAKQgNGLGLTITKRLAESMGGSIYVNSKPYEKTV 119
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-326 3.52e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 50.92  E-value: 3.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 234 VLSNAVKYS-EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTISSGLGLYLVNHVKEKLSICV 312
Cdd:cd16975   12 IISNACQYApEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKNLVEKHGGSL 91

                         90
                 ....*....|....
gi 205785564 313 RIHSELDKGTVVKF 326
Cdd:cd16975   92 IIENSQKGGAEVTV 105
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
129-329 4.07e-08

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 54.41  E-value: 4.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 129 HDIKTPVTAMKLLI----EKEQDLSRKHAL----LYEWSRINDMLDRQLFLTRleyqNKDMYFEHVPLKRLVIEEIQITR 200
Cdd:PRK10364 246 HEIRNPLSSIKGLAkyfaERAPAGGEAHQLaqvmAKEADRLNRVVSELLELVK----PTHLALQAVDLNDLINHSLQLVS 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 201 YISQSKGIGYDLDFEDTL---NVYTDtkwcRMMirQVLSNAVKYSEESM-----IHIRALKESRHVVLEIKDEGKGISEK 272
Cdd:PRK10364 322 QDANSREIQLRFTANDTLpeiQADPD----RLT--QVLLNLYLNAIQAIgqhgvISVTASESGAGVKISVTDSGKGIAAD 395

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 205785564 273 DLPRIFDKGFTSTSNrnntiSSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:PRK10364 396 QLEAIFTPYFTTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
72-329 6.19e-08

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 54.36  E-value: 6.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564   72 LDENIEPEALKH-KSLADTPFQQEMVnYLYG--QITNQK----ALVTHQKQQIQSTEAA---LTDFVHDIKTPVTAMKLL 141
Cdd:PRK09959  655 IDNGIEKRCINHwHTLCNLPASDHAV-YICGwqDITETRdlihALEVERNKAINATVAKsqfLATMSHEIRTPISSIMGF 733

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  142 IE--------KEQDLSRKHALLYEWSRINDMLDRQLFLTRLEYQNKDMYFEHVPLKRLVIEEIQITRYISQSKGIGYDLD 213
Cdd:PRK09959  734 LEllsgsglsKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCS 813

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  214 --FEDTLNVYTDTKWCRMMIRQVLSNAVKYSEE-------SMIHIralkESRHVVLE--IKDEGKGISEKDLPRIFdKGF 282
Cdd:PRK09959  814 stFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEgavkittSLGHI----DDNHAVIKmtIMDSGSGLSQEEQQQLF-KRY 888

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 205785564  283 TSTSNRNNTISSGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:PRK09959  889 SQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
126-328 9.93e-08

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 53.24  E-value: 9.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 126 DFVHDIKTPVTamKLLIEKEQDLSRKHA------LLY----EWSRINDMLDRQLFLTRLEyqNKDMYFEHVP--LKRLVI 193
Cdd:PRK09835 268 DIAHEIRTPIT--NLITQTEIALSQSRSqkeledVLYsnleELTRMAKMVSDMLFLAQAD--NNQLIPEKKMldLADEVG 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 194 EEIQITRYISQSKGIGYDLDFEDTLnVYTDTKWCRMMIRQVLSNAVKYSEESMIHIRALKESRHVV-LEIKDEGKGISEK 272
Cdd:PRK09835 344 KVFDFFEAWAEERGVELRFVGDPCQ-VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVqLVVENPGTPIAPE 422

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 205785564 273 DLPRIFDKGF-TSTSNRNNTISSGLGLYLVNHVKEKLSICVRIHSELDKgtvVKFIF 328
Cdd:PRK09835 423 HLPRLFDRFYrVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARG---TRFVI 476
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
235-329 1.67e-07

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 49.53  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 235 LSNAVKYS----EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTstsnrnntisSGLGLYLVnhvkEKLSI 310
Cdd:COG2172   43 VTNAVRHAyggdPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYSTLAE----------GGRGLFLI----RRLMD 108

                         90
                 ....*....|....*....
gi 205785564 311 CVRIHSELDkGTVVKFIFP 329
Cdd:COG2172  109 EVEYESDPG-GTTVRLVKR 126
PRK15347 PRK15347
two component system sensor kinase;
124-329 1.96e-07

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 52.72  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 124 LTDFVHDIKTP----VTAMKLL-----IEKEQDL--SRKHALLYEWSRINDMLDrqlfLTRLEYQNKDMYFEHVPLKRLV 192
Cdd:PRK15347 402 LTTISHEIRTPlngvLGALELLqntplTAEQMDLadTARQCTLSLLAIINNLLD----FSRIESGQMTLSLEETALLPLL 477

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 193 IEEIQITRYISQSKGIGYD--LDFEDTLNVYTDtkwcRMMIRQVL----SNAVKYSEESMIHIRALKESRHVVLEIKDEG 266
Cdd:PRK15347 478 DQAMLTIQGPAQSKSLTLRtfVGAHVPLYLHLD----SLRLRQILvnllGNAVKFTETGGIRLRVKRHEQQLCFTVEDTG 553

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205785564 267 KGISEKDLPRIFDKGFTSTSNRNNTissGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:PRK15347 554 CGIDIQQQQQIFTPFYQADTHSQGT---GLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 261-322 2.53e-07

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 52.22  E-value: 2.53e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205785564 261 EIKDEGKGISEKDLPRIFDKGF-TSTSNRnntissGLGLYLVNHVKEKLSICVRIHSELDKGT 322
Cdd:PRK11086 471 EVSDDGPGIAPDEIDAIFDKGYsTKGSNR------GVGLYLVKQSVENLGGSIAVESEPGVGT 527
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
195-333 2.58e-07

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 51.94  E-value: 2.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 195 EIQITRYisqSKGIGYDLDFEDTLNvytDTKWCRMMIRQVLSNAVKYSEESM-----IHIRALKESRHVVLEIKDEGKGI 269
Cdd:COG2972  311 EIQKLRF---GDRLEVEIEIDEELL---DLLIPKLILQPLVENAIEHGIEPKegggtIRISIRKEGDRLVITVEDNGVGM 384

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 270 SEKDLPRIFDKGFTSTSNRnntissGLGLYlvnHVKEKLSIC------VRIHSELDKGTVVKFIFPNQNE 333
Cdd:COG2972  385 PEEKLEKLLEELSSKGEGR------GIGLR---NVRERLKLYygeeygLEIESEPGEGTTVTIRIPLEEE 445
PRK10490 PRK10490
sensor protein KdpD; Provisional
 76-315 2.65e-07

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 52.35  E-value: 2.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  76 IEPEALKHKSLadtPFQQEMVNYLYGQITN------------QKALVTHQKQQIQSTEAALTdfvHDIKTPVTAmkLLIE 143
Cdd:PRK10490 614 VEPGNLRQLMI---PEQQRLLETFTLLIANalerltltaseeQARLASEREQLRNALLAALS---HDLRTPLTV--LFGQ 685

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 144 KE---QDLS-------------RKHALlyEWSR-INDMLDrqlfLTRLEYQNKDMYFEHVPLKRLVIEEIQITRYISQSK 206
Cdd:PRK10490 686 AEiltLDLAsegspharqaseiRQQVL--NTTRlVNNLLD----MARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGH 759

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 207 GIGYDLDFEDTLnVYTDTKWCRMMIRQVLSNAVKYS-EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKgFTst 285
Cdd:PRK10490 760 PINLSLPEPLTL-IHVDGPLFERVLINLLENAVKYAgAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDK-FA-- 835

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 205785564 286 snRNNTISS--GLGLylvnhvkeKLSIC---VRIH 315
Cdd:PRK10490 836 --RGNKESAipGVGL--------GLAICraiVEVH 860
PRK09303 PRK09303
histidine kinase;
115-329 3.08e-07

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 51.49  E-value: 3.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 115 QQIQSTEAALTDFVHDIKTPVTAMKLLIE------KEQDLSRKHALLyewSRINDMLDRQL---------FLTRLEYQNK 179
Cdd:PRK09303 146 EQLKFKDRVLAMLAHDLRTPLTAASLALEtlelgqIDEDTELKPALI---EQLQDQARRQLeeierlitdLLEVGRTRWE 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 180 DMYFEHVP--LKRL---VIEEIQiTRYISQSKGIGYDLDfEDTLNVYTDtkwcRMMIRQV----LSNAVKYSEES-MIHI 249
Cdd:PRK09303 223 ALRFNPQKldLGSLcqeVILELE-KRWLAKSLEIQTDIP-SDLPSVYAD----QERIRQVllnlLDNAIKYTPEGgTITL 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 250 RAL-KESRHVVLEIKDEGKGISEKDLPRIFDKGFtSTSNRNNTISSGLGlylvnhvkekLSICVRI---H-------SEL 318
Cdd:PRK09303 297 SMLhRTTQKVQVSICDTGPGIPEEEQERIFEDRV-RLPRDEGTEGYGIG----------LSVCRRIvrvHygqiwvdSEP 365

                        250
                 ....*....|.
gi 205785564 319 DKGTVVKFIFP 329
Cdd:PRK09303 366 GQGSCFHFTLP 376
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 233-329 5.51e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 47.42  E-value: 5.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 233 QVL-SNAVKYS-----EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTStsnrnntiSSGLGLYLVNhVKE 306
Cdd:cd16957    7 QVLvENAIRHAfpkrkENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTS--------EKGTGTALEN-LNR 77

                         90       100
                 ....*....|....*....|....*....
gi 205785564 307 KL------SICVRIHSELDKGTVVKFIFP 329
Cdd:cd16957   78 RLiglfgsEACLHIESEVHGGTEVWFVIP 106
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 223-298 6.96e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 47.07  E-value: 6.96e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205785564 223 DTKWCRMMIRQVLSNAVKYSEES-MIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNN-TISSGLGL 298
Cdd:cd16946    1 DRDRLQQLFVNLLENSLRYTDTGgKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRaSGGSGLGL 78
PRK10337 PRK10337
sensor protein QseC; Provisional
 125-304 1.30e-06

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 49.65  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 125 TDFVHDIKTPVTAMKLLIEKEQdLS------RKHALLYEWS---RINDMLDRQLFLTRLEYQNKDMYFEHVPLKRLVIEE 195
Cdd:PRK10337 242 SDAAHELRSPLAALKVQTEVAQ-LSdddpqaRKKALLQLHAgidRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSA 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 196 IQITRYISQSKGIGYDLDFEDTlnvytdtKWCR--------MMIRQVLSNAVKYSEE-SMIHIRaLKESRhvvLEIKDEG 266
Cdd:PRK10337 321 VMDIYHTAQQAGIDVRLTLNAH-------PVIRtgqplllsLLVRNLLDNAIRYSPQgSVVDVT-LNARN---FTVRDNG 389

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 205785564 267 KGISEKDLPRIFDKgFTSTSNRNNTiSSGLGLYLVNHV 304
Cdd:PRK10337 390 PGVTPEALARIGER-FYRPPGQEAT-GSGLGLSIVRRI 425
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 243-323 1.51e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 46.13  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 243 EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNtissGLGLYLVNHVKEKLSICVRIHSELDKGT 322
Cdd:cd16915   22 PNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER----GIGLALVRQSVERLGGSITVESEPGGGT 97


                 .
gi 205785564 323 V 323
Cdd:cd16915   98 T 98
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
231-329 2.30e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 48.08  E-value: 2.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 231 IRQVLSNAVKYSEESMIHIRALKESRHVVLEIKDEGKGISEKDLPRifdkgftstsnrnntisSGLGLylvNHVKEKLSI 310
Cdd:COG4585  167 VQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPG-----------------GGLGL---RGMRERAEA 226

                         90       100
                 ....*....|....*....|..
gi 205785564 311 C---VRIHSELDKGTVVKFIFP 329
Cdd:COG4585  227 LggtLTIGSAPGGGTRVRATLP 248
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 231-329 3.01e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 45.47  E-value: 3.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 231 IRQVLSNAVKYSEESMIHI----RAL------KESRHVVLEIKDEGKGISEKDLPRIFDKGFTstsnrnnTISSGLGLyl 300
Cdd:cd16920    1 IQQVLINLVRNGIEAMSEGgcerRELtirtspADDRAVTISVKDTGPGIAEEVAGQLFDPFYT-------TKSEGLGM-- 71

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 205785564 301 vnhvkeKLSICVRI----HSELD------KGTVVKFIFP 329
Cdd:cd16920   72 ------GLSICRSIieahGGRLSvespagGGATFQFTLP 104
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 204-329 4.59e-06

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 48.36  E-value: 4.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 204 QSKGIGYDLDFEDTLNVYTDTKWCRmmIRQV----LSNAVKYSEESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFD 279
Cdd:PRK11466 537 KGRPIRLATDIADDLPTALMGDPRR--IRQVitnlLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQ 614

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 205785564 280 KGFTSTSNRNNTissGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:PRK11466 615 PFVQVSGKRGGT---GLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
PRK13557 PRK13557
histidine kinase; Provisional
 252-339 7.85e-06

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 47.36  E-value: 7.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 252 LKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNNTissGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFPNQ 331
Cdd:PRK13557 319 LPPGRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGT---GLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPAS 395


                 ....*...
gi 205785564 332 NEIVAKLS 339
Cdd:PRK13557 396 DQAENPEQ 403
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
234-328 9.10e-06

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 44.59  E-value: 9.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564  234 VLSNAVKYS----EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRifdkgFTSTSNRNNTISSGLGLYLVNHVKEKLS 309
Cdd:pfam13581  39 ACTNAVEHAyregPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPP-----PDLEEPDEDRKEGGRGLALIRGLMDDVE 113

                          90
                  ....*....|....*....
gi 205785564  310 ICVRihselDKGTVVKFIF 328
Cdd:pfam13581 114 YTRG-----GEGNTVRMRK 127
envZ PRK09467
osmolarity sensor protein; Provisional
 129-301 9.54e-06

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 47.21  E-value: 9.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 129 HDIKTPVTAMKLLIE--KEQDLSRKHALLYEWSRINDMLDRqlFLTRLEyQNKDMYFEHVPLKRLVIEEIQitryiSQSk 206
Cdd:PRK09467 238 HDLRTPLTRIRLATEmmSEEDGYLAESINKDIEECNAIIEQ--FIDYLR-TGQEMPMEMADLNALLGEVIA-----AES- 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 207 giGYDLDFEDTLNVYTDTKWCR-MMIRQVLS----NAVKYSeESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFdKG 281
Cdd:PRK09467 309 --GYEREIETALQPGPIEVPMNpIAIKRALAnlvvNAARYG-NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLF-QP 384

                        170       180
                 ....*....|....*....|
gi 205785564 282 FTSTSNRNNTISSGLGLYLV 301
Cdd:PRK09467 385 FTRGDSARGSSGTGLGLAIV 404
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
256-329 1.09e-05

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 47.37  E-value: 1.09e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205785564 256 RHVVLEIKDEGKGISEKDLPRIFDKGFTSTSNRNntissGLGLYLVNHVKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:PRK13837 606 RYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGT-----GLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 159-332 1.16e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 46.82  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 159 SRINDMLdrqlfltrleYQNKDMyfEHVPLKRLVIEEIQITRYISQSKGIGYDLDFEDtLNVYTDTKW-CRMMIRQVLSN 237
Cdd:COG3920  344 ALVHELL----------YQSEDW--EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD-VELPADAAVpLGLILNELVTN 410

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 238 AVKY----SEESMIHIRALKESRHVVLEIKDEGKGISEK-DLPRifdkgftstsnrnntiSSGLGLYLVNHVKEKLSICV 312
Cdd:COG3920  411 ALKHaflsGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDvDPPA----------------RKGLGLRLIRALVRQLGGTL 474

                        170       180
                 ....*....|....*....|
gi 205785564 313 RIHSelDKGTVVKFIFPNQN 332
Cdd:COG3920  475 ELDR--PEGTRVRITFPLAE 492
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 161-334 1.33e-05

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 46.77  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 161 INDMLDrqlfLTRLEyQNKdMYFEHVPLK-RLVIEEIqITrYISQS---KGIGYDLDFEDTL--NVYTDTkwcrMMIRQV 234
Cdd:PRK11107 345 INDILD----FSKLE-AGK-LVLENIPFSlRETLDEV-VT-LLAHSaheKGLELTLNIDPDVpdNVIGDP----LRLQQI 412

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 235 L----SNAVKYSEESMIHI----RALKESR-HVVLEIKDEGKGISEKDLPRIFdKGF----TSTSNRNNtiSSGLGLY-- 299
Cdd:PRK11107 413 ItnlvGNAIKFTESGNIDIlvelRALSNTKvQLEVQIRDTGIGISERQQSQLF-QAFrqadASISRRHG--GTGLGLVit 489

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 205785564 300 --LVNHVKEKLSicvrIHSELDKGTVVKFIFP---NQNEI 334
Cdd:PRK11107 490 qkLVNEMGGDIS----FHSQPNRGSTFWFHLPldlNPNPI 525
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 231-300 3.29e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 42.44  E-value: 3.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205785564 231 IRQVLSN-------AVKYSEESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTStsnrnNTISSGLGLYL 300
Cdd:cd16976    1 IQQVLMNllqnaldAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT-----KPVGKGTGLGL 72
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 230-306 3.41e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 42.56  E-value: 3.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 230 MIRQVLSNAVKYSEESMIHI--RALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTS-TSNRNNTISSGLGLYLVNHVKE 306
Cdd:cd16953    4 VLRNLIGNAISFSPPDTGRItvSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTErPANEAFGQHSGLGLSISRQIIE 83
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 163-279 7.25e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 44.55  E-value: 7.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 163 DMLDRQlfltRLEYQNKDMYFEhvplkrLVIEEIQ-ITRYISQSKGIGYDLDFEDTLNVYTDTKWCRMmiRQVL----SN 237
Cdd:PRK11091 342 DKMERR----KLQLDNQPIDFT------DFLADLEnLSGLQAEQKGLRFDLEPLLPLPHKVITDGTRL--RQILwnliSN 409

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 205785564 238 AVKYSEESMIHIRALKESRHVVL-EIKDEGKGISEKDLPRIFD 279
Cdd:PRK11091 410 AVKFTQQGGVTVRVRYEEGDMLTfEVEDSGIGIPEDELDKIFA 452
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
215-314 1.29e-04

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 43.42  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 215 EDTLNVYTDTKWCRMMIRQVLSNAVKYS-EESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIfDKGFTSTSNRNNTIs 293
Cdd:PRK10755 236 AADITVQGDATLLRLLLRNLVENAHRYSpEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGEL-SKAFVRMDSRYGGI- 313

                         90       100
                 ....*....|....*....|.
gi 205785564 294 sGLGlylvnhvkekLSICVRI 314
Cdd:PRK10755 314 -GLG----------LSIVSRI 323
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 106-329 2.38e-04

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 42.75  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 106 QKALVTHQKQQIQSTEAA-----LTDFVHDIKTPVTAM-------KLLIEKEQDLSRKHALlyewSRINDMLDR-QLFLT 172
Cdd:COG4192  414 EKNLRQTQDELIQAAKMAvvgqtMTSLAHELNQPLNAMsmylfsaKKALEQENYAQLPTSL----DKIEGLIERmDKIIK 489

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 173 RLEYQNK--DMYFEHVPLKRLVIE--EIQITRYISQskgigydldfEDTLNVYTDTKWCRMMIR--QVL----SNAVKYS 242
Cdd:COG4192  490 SLRQFSRksDTPLQPVDLRQVIEQawELVESRAKPQ----------QITLHIPDDLMVQGDQVLleQVLvnllVNALDAV 559

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 243 -EESMIHIRALKESRHVVLEIKDEGKGISekDLPRIFdKGFTSTsnrnNTISSGLGLYLVNHVKEKLSICVRIHSELDKG 321
Cdd:COG4192  560 aTQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLF-TPFTTT----KEVGLGLGLSICRSIMQQFGGDLYLASTLERG 632


                 ....*...
gi 205785564 322 TVVKFIFP 329
Cdd:COG4192  633 AMVILEFN 640
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
231-333 2.96e-04

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 42.53  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 231 IRQVLSNAVKYSEESMIHIRALKESR-HVVLEIKDEGKGISEKDLPrifdkgftstsnrnntissgLGLYLVNHVKE--- 306
Cdd:PRK10935 476 IREATLNAIKHANASEIAVSCVTNPDgEHTVSIRDDGIGIGELKEP--------------------EGHYGLNIMQErae 535

                         90       100
                 ....*....|....*....|....*..
gi 205785564 307 KLSICVRIHSELDKGTVVKFIFPNQNE 333
Cdd:PRK10935 536 RLGGTLTISQPPGGGTTVSLTFPSQQE 562
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 231-301 4.71e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 38.97  E-value: 4.71e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205785564 231 IRQVLSN----AVKYSEESmIHIRALKESRHVVLEIKDEGKGISEKDLPRIFdKGFTSTSNRNNTISSGLGLYLV 301
Cdd:cd16950    1 LKRVLSNlvdnALRYGGGW-VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELF-QPFYRGDNARGTSGTGLGLAIV 73
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 234-314 5.89e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 39.54  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 234 VLSNAVKYSEEsMIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKGftstsNRNNTISSGLGLylvnhvkeKLSICVR 313
Cdd:cd16954   45 LLDNACKWCLE-FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRG-----QRLDEQRPGQGL--------GLAIAKE 110


                 .
gi 205785564 314 I 314
Cdd:cd16954  111 I 111
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 242-322 6.07e-04

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 40.26  E-value: 6.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 242 SEESMIHIRALKESRHVVLEIKDEGKGIS---------EKDLPR---------------IFDKGFtSTSNRNNTISS-GL 296
Cdd:cd16916   67 PPEGTITLRAEHQGNQVVIEVSDDGRGIDrekirekaiERGLITadeaatlsddevlnlIFAPGF-STAEQVTDVSGrGV 145

                         90       100
                 ....*....|....*....|....*.
gi 205785564 297 GLYLVNHVKEKLSICVRIHSELDKGT 322
Cdd:cd16916  146 GMDVVKRSIESLGGTIEVESEPGQGT 171
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
235-278 1.61e-03

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 39.96  E-value: 1.61e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 205785564 235 LSNAVKYSEESMIHIRALKESRHVVLEIKDEGKGISEKDLPRIF 278
Cdd:PRK11644 419 LNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQGF 462
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 235-328 2.91e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 36.48  E-value: 2.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 235 LSNAVKY----SEESMIHIRALKESRHVVLEIKDEGKGiseKDLPRIFDKGftstsnrNNTISSGLGLYLVNHVKEKLSI 310
Cdd:cd16936    9 VTNAVRHayrhDGPGPVRLELDLDPDRLRVEVTDSGPG---FDPLRPADPD-------AGLREGGRGLALIRALMDEVGY 78

                         90
                 ....*....|....*...
gi 205785564 311 cvrihSELDKGTVVKFIF 328
Cdd:cd16936   79 -----RRTPGGKTVWLEL 91
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 229-329 3.84e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 35.99  E-value: 3.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 229 MMIRQVLSNAVKYSEESMIHIRALKESRHVVLEIKDEGKGISEKDLPRifdkgftstsnrnntiSSGLGlyLVNHvKEKL 308
Cdd:cd16917    3 RIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPG----------------GGGFG--LLGM-RERA 63

                         90       100
                 ....*....|....*....|....
gi 205785564 309 SIC---VRIHSELDKGTVVKFIFP 329
Cdd:cd16917   64 ELLggtLTIGSRPGGGTRVTARLP 87
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 124-175 4.07e-03

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 35.23  E-value: 4.07e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 205785564   124 LTDFVHDIKTPVTAMKLLIE--KEQDLSRK-----HALLYEWSRINDMLDRQLFLTRLE 175
Cdd:smart00388   6 LANLSHELRTPLTAIRGYLEllLDTELSEEqreylETILREAERLLRLINDLLDLSRIE 64
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 228-329 5.19e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 36.15  E-value: 5.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 228 RMMIRQVLSNAVKYSEES---MIHIRALKESRHVVLEIKDEGKGISEKDLPRIFDKgFTSTSNRNNTISSGLGLYLVNHV 304
Cdd:cd16921    2 GQVLTNLLGNAIKFRRPRrppRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGI-FQRLHSREEYEGTGVGLAIVRKI 80

                         90       100
                 ....*....|....*....|....*
gi 205785564 305 KEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:cd16921   81 IERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 230-287 5.56e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 37.32  E-value: 5.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205785564 230 MIRQVLSNAVKYSEESMIH---------IRALKESRHVVLEIKDEGKGISEKDLPRIFDKGFTSTSN 287
Cdd:cd16929   47 ILFELLKNAMRATVESHGDdsddlppikVTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQ 113
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 229-329 9.45e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 35.13  E-value: 9.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205785564 229 MMIRQVLSNAVKY-------SEESMIHIRALKESRhVVLEIKDEGKGISEKDLPRifdkgftstSNRNNTISSGLGLYLV 301
Cdd:cd16955    4 LMIQPLVENAIVHgiqekkgKGVVKISVKKQLKNR-LHIAVEDNGIGISPKVIER---------VEQDEMPGNKIGLLNV 73

                         90       100
                 ....*....|....*....|....*....
gi 205785564 302 NH-VKEKLSICVRIHSELDKGTVVKFIFP 329
Cdd:cd16955   74 HQrLKLGYGEGLHIRSRPDPGTLIAFYIP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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