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Conserved domains on  [gi|6093863|sp|Q58509|]
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RecName: Full=Orotate phosphoribosyltransferase; Short=OPRT; Short=OPRTase

Protein Classification

orotate phosphoribosyltransferase( domain architecture ID 10785483)

orotate phosphoribosyltransferase catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

CATH:  3.40.50.2020
EC:  2.4.2.-
Gene Ontology:  GO:0046132|GO:0004588|GO:0000287
PubMed:  11751055
SCOP:  4000253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 1-172 3.04e-75

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


:

Pssm-ID: 440229  Cd Length: 201  Bit Score: 223.88  E-value: 3.04e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    1 MDKKSKLINLLKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKDEDVK---VAGVELGSVPIATA 77
Cdd:COG0461   1 MSYKEELAELLLEIGALLFGHFTLSSGRHSPYYIDCRLVLSYPEALELLGEALAELIKELGPEfdaVAGPATGGIPLAAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863   78 VSIIAQKPLLIVRKKPKDYGTKNKIEGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENLQ 157
Cdd:COG0461  81 VARALGLPAIFVRKEAKDHGTGGQIEGGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDREEGAAENLE 160

                       170
                ....*....|....*
gi 6093863  158 KENVELIPLVTVKEL 172
Cdd:COG0461 161 EAGVPLHSLLTLDDL 175
 
Name Accession Description Interval E-value
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 1-172 3.04e-75

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 223.88  E-value: 3.04e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    1 MDKKSKLINLLKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKDEDVK---VAGVELGSVPIATA 77
Cdd:COG0461   1 MSYKEELAELLLEIGALLFGHFTLSSGRHSPYYIDCRLVLSYPEALELLGEALAELIKELGPEfdaVAGPATGGIPLAAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863   78 VSIIAQKPLLIVRKKPKDYGTKNKIEGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENLQ 157
Cdd:COG0461  81 VARALGLPAIFVRKEAKDHGTGGQIEGGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDREEGAAENLE 160

                       170
                ....*....|....*
gi 6093863  158 KENVELIPLVTVKEL 172
Cdd:COG0461 161 EAGVPLHSLLTLDDL 175
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 1-172 7.28e-70

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 210.01  E-value: 7.28e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863     1 MDKKSKLINLLKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKDEDVK---VAGVELGSVPIATA 77
Cdd:PRK00455   2 KMYAREFIEFLLEIGALLFGHFTLSSGRKSPYYFDCRKLLSYPEALALLGRFLAEAIKDSGIEfdvVAGPATGGIPLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    78 VSIIAQKPLLIVRKKPKDYGTKNKIEGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENLQ 157
Cdd:PRK00455  82 VARALDLPAIFVRKEAKDHGEGGQIEGRRLFGKRVLVVEDVITTGGSVLEAVEAIRAAGAEVVGVAVIVDRQSAAQEVFA 161

                        170
                 ....*....|....*
gi 6093863   158 KENVELIPLVTVKEL 172
Cdd:PRK00455 162 DAGVPLISLITLDDL 176
pyrE TIGR00336
orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in ...
 9-172 7.33e-68

orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate (OMP) in the presence of divalent cations, preferably Mg2+. In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC 4.1.1.23). The combined activity of EC 2.4.2.10 and EC 4.1.1.23 is termed uridine 5'-monophosphate synthase. The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 129436 [Multi-domain]  Cd Length: 173  Bit Score: 204.20  E-value: 7.33e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863      9 NLLKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKD--EDVKVAGVELGSVPIATAVSIIAQKP- 85
Cdd:TIGR00336   1 ELLLEVQALKFGEFTLSSGRKSPYYFNIKLFNTGPELANLIARYAAAIIKShlEFDVIAGPALGGIPIATAVSVKLAKPg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863     86 ----LLIVRKKPKDYGTKNKIEGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLE-GAKENLQKE- 159
Cdd:TIGR00336  81 gdipLCFNRKEAKDHGEGGNIEGELLEGDKVVVVEDVITTGTSILEAVEIIQAAGGQVAGVIIAVDRQErSAGQEFEKEy 160

                         170
                  ....*....|...
gi 6093863    160 NVELIPLVTVKEL 172
Cdd:TIGR00336 161 GLPVISLITLKDL 173
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 49-168 5.83e-23

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 88.22  E-value: 5.83e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863   49 VGEIIAEQIKD---EDVKVAGVELGSVPIATAVSIIAQKPLLIVRKKPKDYGT-------KNKIEGELKEGDKVVIVEDV 118
Cdd:cd06223   1 AGRLLAEEIREdllEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRtpsepygLELPLGGDVKGKRVLLVDDV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6093863  119 TTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENLQKENVELIPLVT 168
Cdd:cd06223  81 IATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELASPGDPVYSLFT 130
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 42-154 2.72e-10

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 55.83  E-value: 2.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863     42 NPEILKLVGEIIA---EQIKDEDVKVAGVELGSVPIATAVSIIAQKPLLIVRKK---PKDYGTKNKIEGE-LKEGDKVVI 114
Cdd:pfam00156   8 NPAILKAVARLAAqinEDYGGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVsynPDTSEVMKTSSALpDLKGKTVLI 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6093863    115 VEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKE 154
Cdd:pfam00156  88 VDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEP 127
 
Name Accession Description Interval E-value
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 1-172 3.04e-75

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 223.88  E-value: 3.04e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    1 MDKKSKLINLLKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKDEDVK---VAGVELGSVPIATA 77
Cdd:COG0461   1 MSYKEELAELLLEIGALLFGHFTLSSGRHSPYYIDCRLVLSYPEALELLGEALAELIKELGPEfdaVAGPATGGIPLAAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863   78 VSIIAQKPLLIVRKKPKDYGTKNKIEGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENLQ 157
Cdd:COG0461  81 VARALGLPAIFVRKEAKDHGTGGQIEGGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDREEGAAENLE 160

                       170
                ....*....|....*
gi 6093863  158 KENVELIPLVTVKEL 172
Cdd:COG0461 161 EAGVPLHSLLTLDDL 175
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 1-172 7.28e-70

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 210.01  E-value: 7.28e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863     1 MDKKSKLINLLKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKDEDVK---VAGVELGSVPIATA 77
Cdd:PRK00455   2 KMYAREFIEFLLEIGALLFGHFTLSSGRKSPYYFDCRKLLSYPEALALLGRFLAEAIKDSGIEfdvVAGPATGGIPLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    78 VSIIAQKPLLIVRKKPKDYGTKNKIEGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENLQ 157
Cdd:PRK00455  82 VARALDLPAIFVRKEAKDHGEGGQIEGRRLFGKRVLVVEDVITTGGSVLEAVEAIRAAGAEVVGVAVIVDRQSAAQEVFA 161

                        170
                 ....*....|....*
gi 6093863   158 KENVELIPLVTVKEL 172
Cdd:PRK00455 162 DAGVPLISLITLDDL 176
pyrE TIGR00336
orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in ...
 9-172 7.33e-68

orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate (OMP) in the presence of divalent cations, preferably Mg2+. In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC 4.1.1.23). The combined activity of EC 2.4.2.10 and EC 4.1.1.23 is termed uridine 5'-monophosphate synthase. The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 129436 [Multi-domain]  Cd Length: 173  Bit Score: 204.20  E-value: 7.33e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863      9 NLLKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKD--EDVKVAGVELGSVPIATAVSIIAQKP- 85
Cdd:TIGR00336   1 ELLLEVQALKFGEFTLSSGRKSPYYFNIKLFNTGPELANLIARYAAAIIKShlEFDVIAGPALGGIPIATAVSVKLAKPg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863     86 ----LLIVRKKPKDYGTKNKIEGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLE-GAKENLQKE- 159
Cdd:TIGR00336  81 gdipLCFNRKEAKDHGEGGNIEGELLEGDKVVVVEDVITTGTSILEAVEIIQAAGGQVAGVIIAVDRQErSAGQEFEKEy 160

                         170
                  ....*....|...
gi 6093863    160 NVELIPLVTVKEL 172
Cdd:TIGR00336 161 GLPVISLITLKDL 173
PRK05500 PRK05500
bifunctional orotidine-5'-phosphate decarboxylase/orotate phosphoribosyltransferase;
7-175 1.44e-34

bifunctional orotidine-5'-phosphate decarboxylase/orotate phosphoribosyltransferase;


Pssm-ID: 180119 [Multi-domain]  Cd Length: 477  Bit Score: 126.34  E-value: 1.44e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863     7 LINLLKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKD-EDVKVAGVELGSVPIATAVSIIAQKP 85
Cdd:PRK05500 290 LILQLYDIGCLLFGEYVQASGATFSYYIDLRKIISNPQLFHQVLSAYAEILKNlTFDRIAGIPYGSLPTATGLALHLHHP 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    86 LLIVRKKPKDYGTKNKIEGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENLQKENVELIP 165
Cdd:PRK05500 370 MIFPRKEVKAHGTRRLIEGNFHPGETVVVVDDILITGKSVMEGAEKLKSAGLNVRDIVVFIDHEQGVKDKLQSHGYQAYS 449

                        170
                 ....*....|
gi 6093863   166 LVTVKELQST 175
Cdd:PRK05500 450 VLTISEITET 459
PRK13809 PRK13809
orotate phosphoribosyltransferase; Provisional
 11-172 3.43e-26

orotate phosphoribosyltransferase; Provisional


Pssm-ID: 184340  Cd Length: 206  Bit Score: 98.76  E-value: 3.43e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    11 LKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKDEDVKV-AGVELGSVPIATAVSIIAQKPLLIV 89
Cdd:PRK13809  17 LYQIGAIKFGKFILASGEETPIYVDMRLVISSPEVLQTIATLIWRLRPSFNSSLlCGVPYTALTLATSISLKYNIPMVLR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    90 RKKPKDYGTKNKI--EGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENLQKENVELIPLV 167
Cdd:PRK13809  97 RKELKNVDPSDAIkvEGLFTPGQTCLVINDMVSSGKSIIETAVALEEEGLVVREALVFLDRQKGACQPLGPQGIKLSSVF 176


                 ....*
gi 6093863   168 TVKEL 172
Cdd:PRK13809 177 TVPDL 181
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 49-168 5.83e-23

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 88.22  E-value: 5.83e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863   49 VGEIIAEQIKD---EDVKVAGVELGSVPIATAVSIIAQKPLLIVRKKPKDYGT-------KNKIEGELKEGDKVVIVEDV 118
Cdd:cd06223   1 AGRLLAEEIREdllEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRtpsepygLELPLGGDVKGKRVLLVDDV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6093863  119 TTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENLQKENVELIPLVT 168
Cdd:cd06223  81 IATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELASPGDPVYSLFT 130
pyrE_Therm TIGR01367
orotate phosphoribosyltransferase, Thermus family; This model represents a distinct clade of ...
 7-173 2.63e-22

orotate phosphoribosyltransferase, Thermus family; This model represents a distinct clade of orotate phosphoribosyltransferases. Members include the experimentally determined example from Thermus aquaticus and additional examples from Caulobacter crescentus, Helicobacter pylori, Mesorhizobium loti, and related species. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273579  Cd Length: 187  Bit Score: 88.30  E-value: 2.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863      7 LINLLKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKDEDVKV---AGVELGSVPIATAVSIIAQ 83
Cdd:TIGR01367   2 VLDIYKQAGALHEGHFLLSSGKHSPYFLQSATLLEHPEALMELGGELAQKILDYGLKVdfiVGPAMGGVILGYEVARQLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863     84 KPLLIVRKKPKdyGTKNKIEGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENlqkenvEL 163
Cdd:TIGR01367  82 VRSIFAEREGG--GMKLRRGFAVKPGEKFVAVEDVVTTGGSLLEAIRAIEGQGGQVVGLACIIDRSQGGKPD------SG 153

                         170
                  ....*....|
gi 6093863    164 IPLVTVKELQ 173
Cdd:TIGR01367 154 VPLMSLKELE 163
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 34-162 3.31e-17

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 74.34  E-value: 3.31e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863   34 IDIKKATT---NPEILKLVGEIIAEQIKDEDV-KVAGVELGSVPIATAVSIIAQKPLLIVRKKPK------------DYG 97
Cdd:COG0503  18 ILFRDITPllgDPELFRAAGDELAERFADKGIdKVVGIEARGFILAAALAYALGVPFVPARKPGKlpgetvseeydlEYG 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6093863   98 TKNKIE---GELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLE-GAKENLQKENVE 162
Cdd:COG0503  98 TGDTLElhkDALKPGDRVLIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFLIELGFlGGREKLRDYPVE 166
PRK02304 PRK02304
adenine phosphoribosyltransferase; Provisional
 42-169 5.40e-15

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 235028  Cd Length: 175  Bit Score: 68.56  E-value: 5.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    42 NPEILKLVGEIIAEQIKDEDV-KVAGVELGSVPIATAVSIIAQKPLLIVRKKPK------------DYGTkNKIE---GE 105
Cdd:PRK02304  32 DPEAFREVIDALVERYKDADIdKIVGIEARGFIFGAALAYKLGIGFVPVRKPGKlpretisesyelEYGT-DTLEihkDA 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6093863   106 LKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLE-GAKENLqkENVELIPLVTV 169
Cdd:PRK02304 111 IKPGDRVLIVDDLLATGGTLEAAIKLLERLGAEVVGAAFVIELPDlGGREKL--EGYPVKSLVKF 173
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 24-169 2.14e-13

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 64.89  E-value: 2.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    24 LASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKDEDVK---VAGVELGSVPIATAVSIIAQKPLLIVRKKPKDYGTKN 100
Cdd:PRK02277  46 EKAPAPKDIHIDWSSIGSSSSRLRYIASAMADMLEKEDEEvdvVVGIAKSGVPLATLVADELGKDLAIYHPKKWDHGEGE 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6093863   101 KIEGELK------EGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLeGAKEnlqKENVELIPLVTV 169
Cdd:PRK02277 126 KKTGSFSrnfasvEGKRCVIVDDVITSGTTMKETIEYLKEHGGKPVAVVVLIDKS-GIDE---IDGVPVYSLIRV 196
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 42-154 2.72e-10

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 55.83  E-value: 2.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863     42 NPEILKLVGEIIA---EQIKDEDVKVAGVELGSVPIATAVSIIAQKPLLIVRKK---PKDYGTKNKIEGE-LKEGDKVVI 114
Cdd:pfam00156   8 NPAILKAVARLAAqinEDYGGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVsynPDTSEVMKTSSALpDLKGKTVLI 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6093863    115 VEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKE 154
Cdd:pfam00156  88 VDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEP 127
PRK12560 PRK12560
adenine phosphoribosyltransferase; Provisional
 43-173 6.18e-08

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 183595  Cd Length: 187  Bit Score: 50.17  E-value: 6.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    43 PEILKLVGEIIAEQIKDEDVKVAGVELGSVPIATAVSIIAQKPLLIVRKKPK----------DYGTkNKIEGEL-----K 107
Cdd:PRK12560  34 PKVLKETAKEIIKYIDKDIDKIVTEEDKGAPLATPVSLLSGKPLAMARWYPYslselnynvvEIGS-EYFEGVVylngiE 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6093863   108 EGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVVVDR--LEGAKENLQKENVELIPLVTVKELQ 173
Cdd:PRK12560 113 KGDRVAIIDDTLSTGGTVIALIKAIENSGGIVSDVICVIEKtqNNGRKKLFTQTGINVKSLVKIDVKP 180
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 43-145 1.12e-04

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 40.73  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6093863    43 PEILKLVGEIIAEQIKDE-DVKVAgVELGSVPIATAVSIIAQKPLLIVRKKPKDYgTKNKIEGELK-------------- 107
Cdd:PRK07322  35 TELTEAAAEALAKRLPTEvDVLVT-PETKGIPLAHALSRRLGKPYVVARKSRKPY-MQDPIIQEVVsittgkpqllvldg 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 6093863   108 ------EGDKVVIVEDVTTTGGSvLKAVKEIREN-GGIVDKVFVV 145
Cdd:PRK07322 113 adaeklKGKRVAIVDDVVSTGGT-LTALERLVERaGGQVVAKAAI 156
PLN02541 PLN02541
uracil phosphoribosyltransferase
 100-145 4.09e-04

uracil phosphoribosyltransferase


Pssm-ID: 215297  Cd Length: 244  Bit Score: 39.38  E-value: 4.09e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 6093863   100 NKIEGELKEGDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVV 145
Cdd:PLN02541 148 NKLPDKFPEGSRVLVVDPMLATGGTIVAAIDELVSRGASVEQIRVV 193
UPRTase pfam14681
Uracil phosphoribosyltransferase; This family includes the enzyme uracil ...
 86-145 5.65e-03

Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.


Pssm-ID: 434124  Cd Length: 204  Bit Score: 35.93  E-value: 5.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6093863     86 LLIVR----KKPKDYgtKNKIEGELKEgDKVVIVEDVTTTGGSVLKAVKEIRENGGIVDKVFVV 145
Cdd:pfam14681  94 IGIQRdeetLQPVEY--YNKLPKDISD-RTVILLDPMLATGGSAIAAIQVLREHGVPEENIVVL 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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