NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|3914378|sp|Q59188|]
View 

RecName: Full=1-acyl-sn-glycerol-3-phosphate acyltransferase; Short=1-AGP acyltransferase; Short=1-AGPAT; AltName: Full=Lysophosphatidic acid acyltransferase; Short=LPAAT

Protein Classification

1-acyl-sn-glycerol-3-phosphate acyltransferase( domain architecture ID 10794602)

1-acyl-sn-glycerol-3-phosphate acyltransferase converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 65-194 1.17e-55

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


:

Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 174.46  E-value: 1.17e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378     65 GIKIIVTGSENIPKKSNVIIMGNHIAAMDPLIFIYTFACPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAAEV 144
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 3914378    145 KAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLY 194
Cdd:TIGR00530  81 AAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
 
Name Accession Description Interval E-value
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 65-194 1.17e-55

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 174.46  E-value: 1.17e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378     65 GIKIIVTGSENIPKKSNVIIMGNHIAAMDPLIFIYTFACPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAAEV 144
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 3914378    145 KAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLY 194
Cdd:TIGR00530  81 AAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 47-246 5.72e-51

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 165.57  E-value: 5.72e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   47 RLSFIMMRACIKISLWLAGIKIIVTGSENIPKKSNVIIMGNHIAAMDPLIFIYTFACPFVILAKHSLLRIPFVNIVLIVM 126
Cdd:COG0204  10 RFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRAL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378  127 GVIFVNRRSIRSAAAAEVKAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLYNTNNFFIKNIIF 206
Cdd:COG0204  90 GAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLP 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 3914378  207 NSGLsVYIHVHPLIDVLKLSEYEKENLTSIIRDQIVKKLE 246
Cdd:COG0204 170 RPGK-VTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLA 208
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 57-246 1.68e-46

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 153.20  E-value: 1.68e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   57 IKISLWLAGIKIIVTGSENIPKKSNVIIMGNHIAAMDPLIFIYTFACPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSI 136
Cdd:cd07989   1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378  137 RSAAAAEVKAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLYNTNNFFIKNIIFNSGLSVYIHV 216
Cdd:cd07989  81 RSAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVRI 160

                       170       180       190
                ....*....|....*....|....*....|
gi 3914378  217 HPLIDvlklseYEKENLTSIIRDQIVKKLE 246
Cdd:cd07989 161 GEPIP------PEGLELAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 67-193 5.24e-36

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 124.31  E-value: 5.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378     67 KIIVTGSENIPKKSNVIIMGNHIAAMDPLIFI---YTFACPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAAE 143
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSlalYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 3914378    144 VKAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTL 193
Cdd:pfam01553  81 EYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAI 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 82-196 3.60e-29

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 106.29  E-value: 3.60e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378      82 VIIMGNHIAAMDPLIFIYTFAC---PFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAAEVKAIKVMREGRSIGI 158
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 3914378     159 FPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLYNT 196
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 67-220 8.94e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 70.91  E-value: 8.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378    67 KIIVTGSENIPKKSN-VIIMGNHIAAMDplIF-IYTFACPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAAEV 144
Cdd:PLN02901  36 KIEVEGLENLPSPDEpAVYVSNHQSFLD--IYtLFHLGRPFKFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLECLK 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3914378   145 KAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLYNTNNFFI--KNIIFNSGlSVYIHVHPLI 220
Cdd:PLN02901 114 RCMELLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVGTGKIMPngKEGILNPG-SVKVVIHPPI 190
 
Name Accession Description Interval E-value
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 65-194 1.17e-55

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 174.46  E-value: 1.17e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378     65 GIKIIVTGSENIPKKSNVIIMGNHIAAMDPLIFIYTFACPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAAEV 144
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 3914378    145 KAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLY 194
Cdd:TIGR00530  81 AAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 47-246 5.72e-51

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 165.57  E-value: 5.72e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   47 RLSFIMMRACIKISLWLAGIKIIVTGSENIPKKSNVIIMGNHIAAMDPLIFIYTFACPFVILAKHSLLRIPFVNIVLIVM 126
Cdd:COG0204  10 RFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRAL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378  127 GVIFVNRRSIRSAAAAEVKAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLYNTNNFFIKNIIF 206
Cdd:COG0204  90 GAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLP 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 3914378  207 NSGLsVYIHVHPLIDVLKLSEYEKENLTSIIRDQIVKKLE 246
Cdd:COG0204 170 RPGK-VTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLA 208
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 57-246 1.68e-46

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 153.20  E-value: 1.68e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   57 IKISLWLAGIKIIVTGSENIPKKSNVIIMGNHIAAMDPLIFIYTFACPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSI 136
Cdd:cd07989   1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378  137 RSAAAAEVKAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLYNTNNFFIKNIIFNSGLSVYIHV 216
Cdd:cd07989  81 RSAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVRI 160

                       170       180       190
                ....*....|....*....|....*....|
gi 3914378  217 HPLIDvlklseYEKENLTSIIRDQIVKKLE 246
Cdd:cd07989 161 GEPIP------PEGLELAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 67-193 5.24e-36

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 124.31  E-value: 5.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378     67 KIIVTGSENIPKKSNVIIMGNHIAAMDPLIFI---YTFACPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAAE 143
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSlalYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 3914378    144 VKAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTL 193
Cdd:pfam01553  81 EYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAI 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 82-196 3.60e-29

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 106.29  E-value: 3.60e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378      82 VIIMGNHIAAMDPLIFIYTFAC---PFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAAEVKAIKVMREGRSIGI 158
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 3914378     159 FPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLYNT 196
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 65-202 5.04e-16

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 73.60  E-value: 5.04e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   65 GIKIIVTGSENIPKKSNVIIMGNHIAAMDPLIFIYTFAC-----PFVILAKHSLLRIPFVNIvlivMGVIFVNRRSIRSA 139
Cdd:cd06551  11 FVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFLLLERglrrdVYGLMDEELLERYPFFTR----LGAFSVDRDSPRSA 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3914378  140 AAAEVKAIKVMRE-GRSIGIFPEGTRNRgGDTRV--FKKGSIKMALKTGTSILPVTLYNTNNFFIK 202
Cdd:cd06551  87 AKSLKYVARLLSKpGSVVWIFPEGTRTR-RDKRPlqFKPGVAHLAEKAGVPIVPVALRYTFELFEQ 151
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 67-220 8.94e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 70.91  E-value: 8.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378    67 KIIVTGSENIPKKSN-VIIMGNHIAAMDplIF-IYTFACPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAAEV 144
Cdd:PLN02901  36 KIEVEGLENLPSPDEpAVYVSNHQSFLD--IYtLFHLGRPFKFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLECLK 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3914378   145 KAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLYNTNNFFI--KNIIFNSGlSVYIHVHPLI 220
Cdd:PLN02901 114 RCMELLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVGTGKIMPngKEGILNPG-SVKVVIHPPI 190
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 57-200 1.42e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 70.33  E-value: 1.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   57 IKISLWLAGI-KIIVTGSENiPKKSNVIIMGNHIAAMDPLIFIYTFacPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRS 135
Cdd:cd07991   1 ARVLLFAFGFyVIKVHGKPD-PPEAPRIIVANHTSFIDPLILFSDL--FPSIVAKKELGKLPFIGTILRALGCIFVDRSE 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3914378  136 I--RSAAAAEVKAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGsikmALKTGTSILPVTL-YNTNNFF 200
Cdd:cd07991  78 PkdRKKVVEEIKERATDPNWPPILIFPEGTTTNGKALIMFKKG----AFEPGVPVQPVAIrYPNKFVD 141
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 53-236 2.91e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 69.21  E-value: 2.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   53 MRACIKISLWLAGIKIIVTGSENIPKKSNVIIMGNHI-AAMDPLIFIYTFACPFVILAKHSLLRIPFVNIVLIVMGVIFV 131
Cdd:cd07992   1 VRLLSRVILRIYFRRITVVGRENVPKDGPVIFLGNHPnALIDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378  132 NRR--------SIRSAAAAEVKAIKVMREGRSIGIFPEGTRNRGGDTRVFKKGSIKMAL------KTGTSILPVTLyntn 197
Cdd:cd07992  81 YRPkdlarggiGKISNAAVFDAVGEALKAGGAIGIFPEGGSHDRPRLLPLKAGAARMALealeagQKDVKIVPVGL---- 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 3914378  198 NFFIKNiIFNSGLSVY----IHVHPLIDVLKLSEYEKENLTSI 236
Cdd:cd07992 157 NYEDKS-RFRSRVLVEfgkpISVSAFEEAEASRDVEKKLINQL 198
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 70-200 3.16e-12

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 63.85  E-value: 3.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   70 VTGSENIPKKSNVIIMGNH-IAAMDplifIYTFACPFVI---------LAKHSLLRIPFVNIVLIVMGVIFVNRRSirsa 139
Cdd:cd07987  10 VRGLENIPDEGPALLVHPHgGLPID----GALLAAAFLLlfpgrlpraLADHFLFPLPGLRDLLRRLGAVPGSREN---- 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3914378  140 aaaevkAIKVMREGRSIGIFPEGTR---NRGGDTRV----FKKGSIKMALKTGTSILPVTLYNTNNFF 200
Cdd:cd07987  82 ------CVRLLREGELVLIFPGGARealKSKREEYYllwkKRKGFARLALRAGAPIVPVFTFGEEELF 143
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 63-236 3.12e-11

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 61.57  E-value: 3.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378    63 LAGIKIIVTGSENIPKKSNVIIMGNHIAAMDPLIFIYTFACPFVILAKHSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAA 142
Cdd:PRK15018  48 LFGLKVECRKPADAESYGNAIYIANHQNNYDMVTASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGT 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   143 EVKAIKVMREGR-SIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTLYNTNNFFIKNIIfNSGLsVYIHVHPLID 221
Cdd:PRK15018 128 IAEVVNHFKKRRiSIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSTTSNKINLNRL-HNGL-VIVEMLPPID 205

                        170
                 ....*....|....*
gi 3914378   222 VlklSEYEKENLTSI 236
Cdd:PRK15018 206 V---SQYGKDQVREL 217
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 62-189 7.67e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 59.56  E-value: 7.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   62 WLAGIKIIVTGSENIPKKSNVIIMGNHIAAMDPL----IFIYTFACPFV-ILAKHSLLRIPFVNIVLIVMGVIFVNRRSI 136
Cdd:cd07990   6 WLSGVKVVVYGDEPKLPKERALIISNHRSEVDWLvlwmLADRFGRLGRLkIVLKDSLKYPPLGGWGWQLGEFIFLKRKWE 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3914378  137 RSAAAAE--VKAIKVMREGRSIGIFPEGTRNrggdTRVFKKGSIKMALKTGTSIL 189
Cdd:cd07990  86 KDEKTIKrqLKRLKDSPEPFWLLIFPEGTRF----TEEKKERSQEFAEKNGLPPL 136
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 67-193 4.32e-09

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 56.47  E-value: 4.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378     67 KIIVTGSENIPKKSNVIIMGNHIAAMDPLIFiyTFACP----FVILAkhSLLRIPFVNIVLIVMGVIFVNRRSIRSAAAA 142
Cdd:PRK08633  428 RLRVEGRENIPAKGGALLLGNHVSWIDWALL--QAASPrpirFVMER--SIYEKWYLKWFFKLFGVIPISSGGSKESLEF 503

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 3914378    143 EVKAIKvmrEGRSIGIFPEGTRNRGGDTRVFKKGSIKMALKTGTSILPVTL 193
Cdd:PRK08633  504 IRKALD---DGEVVCIFPEGAITRNGQLNEFKRGFELIVKGTDVPIIPFYI 551
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 61-193 5.08e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 53.76  E-value: 5.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   61 LWLAGIKIIVTgSENIPKksNVIIMGNHIAAMDpliFIYTFACPFV------ILAKHSLLRIPFVNIvLIVMGVIFVNRR 134
Cdd:cd07988   5 LRLSGWRIEGE-PPNKPK--FVVIGAPHTSNWD---FVLGLLAAFAlglkisFLGKHSLFKPPLGPF-MRWLGGIPVDRS 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 3914378  135 SIRSAAAAEVKAIKvMREGRSIGIFPEGTRNRGGDtrvFKKGSIKMALKTGTSILPVTL 193
Cdd:cd07988  78 RAGGLVEQVVEEFR-RREEFVLAIAPEGTRSKVDK---WKTGFYHIARGAGVPILLVYL 132
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 66-191 7.61e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 54.18  E-value: 7.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   66 IKIIVTGSENIPKKSNVIIMGNH-IAAMDPLIFIYTFAC---PFVILAKHSLLRIPFVNIVLivmgvIFVNRRSIRSAAA 141
Cdd:cd07986   8 LEVDVSGLENIPKDGPVVIVANHpFGILDGLILADLLGSvrpDVRILANQLLSKIPELRDLF-----IPVDPLEGRAALA 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378  142 AEVKAIKVM----REGRSIGIFPEGT-----RNRGGDT-RVFKKGSIKMALKTGTSILPV 191
Cdd:cd07986  83 KNRESLREAlrhlKNGGALIIFPAGRvstasPPFGRVSdRPWNPFVARLARKAKAPVVPV 142
LPLAT_DUF374-like cd07983
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; ...
 59-203 9.50e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are the uncharacterized DUF374 phospholipid/glycerol acyltransferases and similar proteins.


Pssm-ID: 153245 [Multi-domain]  Cd Length: 189  Bit Score: 47.98  E-value: 9.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   59 ISLWLAGIKIIVTGSEN----IPKKSNVIIMG--NHIAAMdplIFIYTFACPFVILAKHS----LLripfvNIVLIVMGV 128
Cdd:cd07983   1 LRLLYLTLRWRVIGDESadalIAQGEPVILAFwhGRLLLM---PYLFRRRKRIAALISRSkdgeII-----ARVLERLGI 72

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3914378  129 IFVNRRSIRSAAAAEVKAIKVMREGRSIGIFPEGTRnrgGDTRVFKKGSIKMALKTGTSILPVTlYNTNNFFIKN 203
Cdd:cd07983  73 RVVRGSSSRGGAAALREMLRALKDGYNIAITPDGPR---GPRYKVKPGVILLARKSGAPIVPVA-IAASRAWRLK 143
COG3176 COG3176
Putative hemolysin [General function prediction only];
74-191 4.72e-04

Putative hemolysin [General function prediction only];


Pssm-ID: 442409  Cd Length: 270  Bit Score: 40.41  E-value: 4.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378   74 ENIPKKSNVIIMGNH-IAAMDPLIFIY---TFACPFVILAKHSLLRIPFVnivLIVMGVIFVNRRSIRSAAAAevkaIKV 149
Cdd:COG3176  65 DRIDADGHLLVVANHpLGILDGLALLKlvgTVRPDYRILANDLALRIPGG---FYSELEFPVDPFNLETLKAA----RRH 137

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 3914378  150 MREGRSIGIFPEGTRNRGGDT--RVFKKGSIKMALKTGTSILPV 191
Cdd:COG3176 138 LLEGGRSCVFPAGRVSGARRVidLLWSGLAAKLARKAGAPVVPV 181
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
70-191 3.55e-03

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 38.41  E-value: 3.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3914378     70 VTGSENIPK-KSNVIIMGNHIAAMD-PLIFIY-----TFACPFVIlAKHSLLRiPFVNIVLiVMGVIFVNRRSIRSAaaa 142
Cdd:PRK06814  443 VKGLENLQKaGKKAVIAANHVSFLDgPLLAAYlpeepTFAIDTDI-AKAWWVK-PFLKLAK-ALPVDPTNPMATRTL--- 516

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 3914378    143 evkaIKVMREGRSIGIFPEGtrnR----GGDTRVFkKGSIKMALKTGTSILPV 191
Cdd:PRK06814  517 ----IKEVQKGEKLVIFPEG---RitvtGSLMKIY-DGPGMIADKAGAMVVPV 561
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH