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Conserved domains on  [gi|74755676|sp|Q5JTN6|]
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RecName: Full=WD repeat-containing protein 38

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-298 7.78e-98

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 294.13  E-value: 7.78e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTV 171
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 172 HIWDlrmVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Cdd:COG2319 271 RLWD---LATGELLRTLTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74755676 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Cdd:COG2319 348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-298 7.78e-98

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 294.13  E-value: 7.78e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTV 171
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 172 HIWDlrmVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Cdd:COG2319 271 RLWD---LATGELLRTLTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74755676 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Cdd:COG2319 348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-300 3.50e-78

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 239.93  E-value: 3.50e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLR 99
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 180 TPAvshQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
Cdd:cd00200 168 KCV---ATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74755676 259 VWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Cdd:cd00200 245 VWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 13-260 6.65e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.04  E-value: 6.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   13 RVKFFGQHGGEVNSS------AFSPDGQMLLTGSEDGCVYGWETRS--------GQLLWRLGGHTGPVKFCRFSPDGHLF 78
Cdd:PLN00181 469 RVKADLKQGDLLNSSnlvcaiGFDRDGEFFATAGVNKKIKIFECESiikdgrdiHYPVVELASRSKLSGICWNSYIKSQV 548

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF-SPDSRQLASGGWDKRVMLWDVQSGQMLRlLVGHRDSIQSSDF-S 156
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIG-TIKTKANICCVQFpS 627

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  157 PTVNCLATGSWDSTVHIWDLRmvTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTS------SLLIQLK 230
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDLR--NPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFM 705

                        250       260       270
                 ....*....|....*....|....*....|
gi 74755676  231 GHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Cdd:PLN00181 706 GHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-91 5.39e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 5.39e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 74755676     52 SGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-133 3.13e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 3.13e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 74755676    96 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-298 7.78e-98

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 294.13  E-value: 7.78e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTV 171
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 172 HIWDlrmVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Cdd:COG2319 271 RLWD---LATGELLRTLTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74755676 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Cdd:COG2319 348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
7-300 1.77e-91

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 277.95  E-value: 1.77e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   7 ATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCT 86
Cdd:COG2319  64 DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  87 VRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166
Cdd:COG2319 144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 167 WDSTVHIWDLRmvTPAVSHQaLEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
Cdd:COG2319 224 ADGTVRLWDLA--TGKLLRT-LTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 74755676 246 LWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Cdd:COG2319 301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355
WD40 COG2319
WD40 repeat [General function prediction only];
20-264 6.01e-83

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.99  E-value: 6.01e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLR 99
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 180 TPAvshQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
Cdd:COG2319 321 KLL---RTLTGHTGAVRSVAFSPDGkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                ....*.
gi 74755676 259 VWDCNT 264
Cdd:COG2319 398 LWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
5-298 2.72e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 249.06  E-value: 2.72e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   5 VPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCD 84
Cdd:COG2319  20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  85 CTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLAT 164
Cdd:COG2319 100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 165 GSWDSTVHIWDLRmvTPAVSHqALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
Cdd:COG2319 180 GSDDGTVRLWDLA--TGKLLR-TLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP 256

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 74755676 244 DELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Cdd:COG2319 257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-300 3.50e-78

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 239.93  E-value: 3.50e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLR 99
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 180 TPAvshQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
Cdd:cd00200 168 KCV---ATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74755676 259 VWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Cdd:cd00200 245 VWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-298 1.65e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 217.97  E-value: 1.65e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRmvtPAVSHQALEGHSANISCLCYS-ASGLLASGSWDKTIHI 217
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVAFSpDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
Cdd:cd00200 162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241


                .
gi 74755676 298 T 298
Cdd:cd00200 242 T 242
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-261 2.32e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.20  E-value: 2.32e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLR 99
Cdd:cd00200  50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Cdd:cd00200 130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 180 TpavSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
Cdd:cd00200 210 K---CLGTLRGHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286


                ...
gi 74755676 259 VWD 261
Cdd:cd00200 287 IWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
12-222 3.62e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 215.55  E-value: 3.62e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTV 171
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 74755676 172 HIWDLRMVTPAvshQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTT 222
Cdd:COG2319 355 RLWDLATGELL---RTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
28-298 5.34e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.46  E-value: 5.34e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  28 AFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS 107
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 108 VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRmvTPAVSHQa 187
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRT- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 266
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                       250       260       270
                ....*....|....*....|....*....|..
gi 74755676 267 CLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-219 6.87e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 190.62  E-value: 6.87e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAK 96
Cdd:cd00200  89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  97 CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL 248

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 74755676 177 RMVTPavsHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWK 219
Cdd:cd00200 249 RTGEC---VQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-298 1.78e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.67  E-value: 1.78e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  97 CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 177 RmvTPAVSHQaLEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSR 255
Cdd:cd00200  81 E--TGECVRT-LTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 74755676 256 MVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Cdd:cd00200 158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-175 5.68e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.81  E-value: 5.68e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVA 93
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  94 RAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHI 173
Cdd:cd00200 208 TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                ..
gi 74755676 174 WD 175
Cdd:cd00200 288 WD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-133 4.08e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 4.08e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:cd00200 168 KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 74755676  92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Cdd:cd00200 248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 13-260 6.65e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.04  E-value: 6.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   13 RVKFFGQHGGEVNSS------AFSPDGQMLLTGSEDGCVYGWETRS--------GQLLWRLGGHTGPVKFCRFSPDGHLF 78
Cdd:PLN00181 469 RVKADLKQGDLLNSSnlvcaiGFDRDGEFFATAGVNKKIKIFECESiikdgrdiHYPVVELASRSKLSGICWNSYIKSQV 548

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF-SPDSRQLASGGWDKRVMLWDVQSGQMLRlLVGHRDSIQSSDF-S 156
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIG-TIKTKANICCVQFpS 627

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  157 PTVNCLATGSWDSTVHIWDLRmvTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTS------SLLIQLK 230
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDLR--NPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFM 705

                        250       260       270
                 ....*....|....*....|....*....|
gi 74755676  231 GHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Cdd:PLN00181 706 GHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 71-261 1.42e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   71 FSPDGHLFASASCDCTVRLWDvarakCLRVLKG----HQRSVETVSFSPDS---------RQLASGGWDKRVMLWDVQSG 137
Cdd:PLN00181 491 FDRDGEFFATAGVNKKIKIFE-----CESIIKDgrdiHYPVVELASRSKLSgicwnsyikSQVASSNFEGVVQVWDVARS 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  138 QMLRLLVGHRDSIQSSDFS---PTVncLATGSWDSTVHIWDlrmVTPAVSHQALEGhSANISCLCY-SASGL-LASGSWD 212
Cdd:PLN00181 566 QLVTEMKEHEKRVWSIDYSsadPTL--LASGSDDGSVKLWS---INQGVSIGTIKT-KANICCVQFpSESGRsLAFGSAD 639

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 74755676  213 KTIHIWKPTTSSL-LIQLKGHVTWVKSIAFSpDELWLASAGYSRMVKVWD 261
Cdd:PLN00181 640 HKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD 688
PTZ00421 PTZ00421
coronin; Provisional
 18-195 6.82e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 59.52  E-value: 6.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   18 GQHGgEVNSSAFSP-DGQMLLTGSEDGCVYGWETRSGQL-------LWRLGGHTGPVKFCRFSPDG-HLFASASCDCTVR 88
Cdd:PTZ00421  73 GQEG-PIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   89 LWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS-------IQSSDFSPTVNC 161
Cdd:PTZ00421 152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrclwAKRKDLIITLGC 231

                        170       180       190
                 ....*....|....*....|....*....|....
gi 74755676  162 laTGSWDSTVHIWDLRMVTPAVSHQALEGHSANI 195
Cdd:PTZ00421 232 --SKSQQRQIMLWDTRKMASPYSTVDLDQSSALF 263
PTZ00420 PTZ00420
coronin; Provisional
 87-271 1.57e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.81  E-value: 1.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   87 VRLWDVARAKCLRVLKGHQRSVETVSFSP-DSRQLASGGWDKRVMLWDV----QSGQMLR----LLVGHRDSIQSSDFSP 157
Cdd:PTZ00420  56 IRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIphndESVKEIKdpqcILKGHKKKISIIDWNP 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  158 -TVNCLATGSWDSTVHIWDLRMvtpavSHQALE-GHSANISCLCYSASGLLASGSW-DKTIHIWKP----TTSSLLIQLK 230
Cdd:PTZ00420 136 mNYYIMCSSGFDSFVNIWDIEN-----EKRAFQiNMPKKLSSLKWNIKGNLLSGTCvGKHMHIIDPrkqeIASSFHIHDG 210

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 74755676  231 GHVT---WVKsiAFSPDELWLASAGYS----RMVKVWDC-NTGKCLETL 271
Cdd:PTZ00420 211 GKNTkniWID--GLGGDDNYILSTGFSknnmREMKLWDLkNTTSALVTM 257
PTZ00421 PTZ00421
coronin; Provisional
 206-311 3.63e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.60  E-value: 3.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  206 LASGSWDKTIHIW-------KPTTSSLLIQLKGHVTWVKSIAFSPDEL-WLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
Cdd:PTZ00421  91 LFTASEDGTIMGWgipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                         90       100       110
                 ....*....|....*....|....*....|....
gi 74755676  278 AHTCAFTPDGKILVSGAADQTRRQIsrtskSPRD 311
Cdd:PTZ00421 171 ITSLEWNLDGSLLCTTSKDKKLNII-----DPRD 199
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-91 5.39e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 5.39e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 74755676     52 SGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-133 1.09e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.09e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 74755676     96 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-133 3.13e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 3.13e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 74755676    96 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
53-91 4.09e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 4.09e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 74755676    53 GQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 30-210 5.65e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 5.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   30 SPDGQMLLTGSEDGCVYGWETRSGQllwRLGGHTGPVKFC--RFSPD-GHLFASASCDCTVRLWDVARAKC-LRVLKGHQ 105
Cdd:PLN00181 585 SADPTLLASGSDDGSVKLWSINQGV---SIGTIKTKANICcvQFPSEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHS 661

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  106 RSVETVSFSpDSRQLASGGWDKRVMLWDVQ---SG---QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Cdd:PLN00181 662 KTVSYVRFV-DSSTLVSSSTDNTLKLWDLSmsiSGineTPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFP 740

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 74755676  180 TPAVSHQ--------ALEGHSAN--ISCLCY--SASGLLASGS 210
Cdd:PLN00181 741 MPVLSYKfktidpvsGLEVDDASqfISSVCWrgQSSTLVAANS 783
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 136-175 9.64e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 9.64e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 74755676    136 SGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 222-261 1.77e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 1.77e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 74755676    222 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
201-300 5.48e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 5.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676 201 SASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHT 280
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                        90       100
                ....*....|....*....|
gi 74755676 281 CAFTPDGKILVSGAADQTRR 300
Cdd:COG2319  84 VAFSPDGRLLASASADGTVR 103
WD40 pfam00400
WD domain, G-beta repeat;
137-175 7.27e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 7.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 74755676   137 GQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
223-261 7.48e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 7.48e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 74755676   223 SSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 28-158 1.06e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 46.96  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676   28 AFSPDGQMLLTGSEDGCVYGWETRS------------GQLLWRlgghTGPVkfcrFSPDGHLFASASCDCTVRLWDVARA 95
Cdd:COG4946  349 AWSPDGKSIAYFSDASGEYELYIAPadgsgepkqltlGDLGRV----FNPV----WSPDGKKIAFTDNRGRLWVVDLASG 420

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74755676   96 KCLRVLKG-HQRSVETVSFSPDSRQLA----SGGWDKRVMLWDVQSGQMLRLLVGhrdsiQSSDFSPT 158
Cdd:COG4946  421 KVRKVDTDgYGDGISDLAWSPDSKWLAyskpGPNQLSQIFLYDVETGKTVQLTDG-----RYDDGSPA 483
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-219 2.17e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.17e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 74755676    188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWK 219
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
188-218 3.14e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.14e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 74755676   188 LEGHSANISCLCYSASG-LLASGSWDKTIHIW 218
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 193-297 3.97e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 3.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  193 ANISCLCYSA--SGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP-DELWLASAGYSRMVKVWDCNTGKCLE 269
Cdd:PLN00181 533 SKLSGICWNSyiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIG 612

                         90       100       110
                 ....*....|....*....|....*....|
gi 74755676  270 TLKGVLDVAhtCAFTPD--GKILVSGAADQ 297
Cdd:PLN00181 613 TIKTKANIC--CVQFPSesGRSLAFGSADH 640
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 12-49 6.09e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 6.09e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 74755676     12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWE 49
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
RAB3GAP2_N pfam14655
Rab3 GTPase-activating protein regulatory subunit N-terminus; This family includes the ...
 93-148 8.80e-05

Rab3 GTPase-activating protein regulatory subunit N-terminus; This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily.


Pssm-ID: 464240  Cd Length: 416  Bit Score: 43.84  E-value: 8.80e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 74755676    93 ARAKCLRVLKGHQRSVETVSFSPDSRQLA---SGGwdkRVMLWDVQSGQMLRLLVGHRD 148
Cdd:pfam14655 297 APLSCRFGLKDSKREGESITLSPSGRLAAvtdSLG---RVLLLDVQAGVAVRLWKGYRD 352
WD40 pfam00400
WD domain, G-beta repeat;
12-49 3.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.63e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 74755676    12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWE 49
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 132-218 4.68e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 4.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676  132 WDVQSGQML---RL-----------LVGHRDSIQSSDFSPTVN-CLATGSWDSTVHIWDLRMVTPAVSHQA-----LEGH 191
Cdd:PTZ00420  45 WEVEGGGLIgaiRLenqmrkppvikLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNDESVKEIKdpqciLKGH 124

                         90       100
                 ....*....|....*....|....*....
gi 74755676  192 SANISCLCYSASG--LLASGSWDKTIHIW 218
Cdd:PTZ00420 125 KKKISIIDWNPMNyyIMCSSGFDSFVNIW 153
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 28-114 1.27e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74755676    28 AFSPDGQMLLTGSEDGCVygWETR-SGQLLW--RLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGH 104
Cdd:pfam12894   2 SWCPTMDLIALATEDGEL--LLHRlNWQRVWtlSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAG 79

                          90
                  ....*....|
gi 74755676   105 QRSVETVSFS 114
Cdd:pfam12894  80 SDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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