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Conserved domains on  [gi|67461903|sp|Q5NR65|]
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RecName: Full=Tol-Pal system protein TolB; Flags: Precursor

Protein Classification

Tol-Pal system beta propeller repeat protein TolB( domain architecture ID 11495503)

Tol-Pal system beta propeller repeat protein TolB is part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Gene Ontology:  GO:0042597|GO:0007049|GO:0017038|GO:0051301
PubMed:  32152098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 32-454 0e+00

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


:

Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 512.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903    32 AANQGDNRRILRVDITGGISQPMPIAVPVMPTPSSVetlaGTTAVLGRQVASVISNDLKSSGLFTPSQQASL-HNVSFPE 110
Cdd:TIGR02800   1 LAVSTPAAADLTIEITKGGASALPIAVAPFSNDGGG----SPDANLGESIAEVIANDLKRSGLFSPVDKAGLpSNPIAES 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   111 vtAPQYSYWLSSGAQALVQGFVQANGDGTLTVGCYLYDVFASQEML-HKGFVVKPADWRRAAHKCADAVYTRLTGEGPYF 189
Cdd:TIGR02800  77 --QVNPAAWQALGADALVVGSVTPNGNGRYTVRFRLYDVVSGQLQLlGKQYTVTASQLRRVAHRIADAIYEKLTGERGAF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   190 DSRIVYISETGpkNHRLKRLAIMDQDGANHRFLTNGQSMVLTPRFAPNQQTVTYLSYVGNSPRIYVYTLGSGHVRLVVNK 269
Cdd:TIGR02800 155 STRIAYVSKSG--KSRRYELQVADYDGANPQTITRSREPILSPAWSPDGQKLAYVSFESGKPEIYVQDLATGQREKVASF 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   270 PNTTFAPRFSPDGKTIVFSMSVAGNTDIYKVPVSGGQATRLTTSPGIDTAPSFSPDGSKIVFESDRSGSQQIYIMNADGS 349
Cdd:TIGR02800 233 PGMNGAPAFSPDGSKLAVSLSKDGNPDIYVMDLDGKQLTRLTNGPGIDTEPSWSPDGKSIAFTSDRGGSPQIYMMDADGG 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   350 NQNRISFGSGRYATPVWSPRGDLIAFTKL-GGGFHVGVMKTDGSGEQILTNGWQDEGPSWSPNGRVIAFFRTARNSGhte 428
Cdd:TIGR02800 313 EVRRLTFRGGYNASPSWSPDGDLIAFVHReGGGFNIAVMDLDGGGERVLTDTGLDESPSFAPNGRMILYATTRGGRG--- 389

                         410       420
                  ....*....|....*....|....*...
gi 67461903   429 LWSVDLTGVNERHIPTPLDG--SDPSWG 454
Cdd:TIGR02800 390 VLGLVSTDGRFRARLPLGNGdvREPAWS 417
 
Name Accession Description Interval E-value
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 32-454 0e+00

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 512.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903    32 AANQGDNRRILRVDITGGISQPMPIAVPVMPTPSSVetlaGTTAVLGRQVASVISNDLKSSGLFTPSQQASL-HNVSFPE 110
Cdd:TIGR02800   1 LAVSTPAAADLTIEITKGGASALPIAVAPFSNDGGG----SPDANLGESIAEVIANDLKRSGLFSPVDKAGLpSNPIAES 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   111 vtAPQYSYWLSSGAQALVQGFVQANGDGTLTVGCYLYDVFASQEML-HKGFVVKPADWRRAAHKCADAVYTRLTGEGPYF 189
Cdd:TIGR02800  77 --QVNPAAWQALGADALVVGSVTPNGNGRYTVRFRLYDVVSGQLQLlGKQYTVTASQLRRVAHRIADAIYEKLTGERGAF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   190 DSRIVYISETGpkNHRLKRLAIMDQDGANHRFLTNGQSMVLTPRFAPNQQTVTYLSYVGNSPRIYVYTLGSGHVRLVVNK 269
Cdd:TIGR02800 155 STRIAYVSKSG--KSRRYELQVADYDGANPQTITRSREPILSPAWSPDGQKLAYVSFESGKPEIYVQDLATGQREKVASF 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   270 PNTTFAPRFSPDGKTIVFSMSVAGNTDIYKVPVSGGQATRLTTSPGIDTAPSFSPDGSKIVFESDRSGSQQIYIMNADGS 349
Cdd:TIGR02800 233 PGMNGAPAFSPDGSKLAVSLSKDGNPDIYVMDLDGKQLTRLTNGPGIDTEPSWSPDGKSIAFTSDRGGSPQIYMMDADGG 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   350 NQNRISFGSGRYATPVWSPRGDLIAFTKL-GGGFHVGVMKTDGSGEQILTNGWQDEGPSWSPNGRVIAFFRTARNSGhte 428
Cdd:TIGR02800 313 EVRRLTFRGGYNASPSWSPDGDLIAFVHReGGGFNIAVMDLDGGGERVLTDTGLDESPSFAPNGRMILYATTRGGRG--- 389

                         410       420
                  ....*....|....*....|....*...
gi 67461903   429 LWSVDLTGVNERHIPTPLDG--SDPSWG 454
Cdd:TIGR02800 390 VLGLVSTDGRFRARLPLGNGdvREPAWS 417
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 285-441 6.37e-59

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 190.65  E-value: 6.37e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903 285 IVFSMSVAGNTDIYKVPVSGGQATRLTTSPGIDTAPSFSPDGSKIVFESDRSGSQQIYIMNADGSNQNRISFGSGRYATP 364
Cdd:COG0823   1 LAFTLSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461903 365 VWSPRGDLIAFTKL-GGGFHVGVMKTDGSGEQILTNGWQdeGPSWSPNGRVIAFFRTArnSGHTELWSVDLTGVNERH 441
Cdd:COG0823  81 SWSPDGKRLAFVSRsDGRFDIYVLDLDGGAPRRLTDGPG--SPSWSPDGRRIVFSSDR--GGRPDLYVVDLDGRKRRL 154
tolB PRK01029
Tol-Pal system protein TolB;
168-454 1.35e-32

Tol-Pal system protein TolB;


Pssm-ID: 234889 [Multi-domain]  Cd Length: 428  Bit Score: 128.34  E-value: 1.35e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  168 RRAAHKCADAVYTRLTGEGPYFDSRIVYISETGPKNHRLKR--LAIMDQDGANHRFLTNGQSMVLTPRFAP--NQQTVTY 243
Cdd:PRK01029 124 RQKIHEAADTIHYALTGVPGISSGKIIFSLSTTNSDTELKQgeLWSVDYDGQNLRPLTQEHSLSITPTWMHigSGFPYLY 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  244 LSYVGNSPRIYVYTLGSGHVRLVVNKPNTTFAPRFSPDGKTIVFSMSVAGNTDIYKVPVS------GGQATRLTTSPGID 317
Cdd:PRK01029 204 VSYKLGVPKIFLGSLENPAGKKILALQGNQLMPTFSPRKKLLAFISDRYGNPDLFIQSFSletgaiGKPRRLLNEAFGTQ 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  318 TAPSFSPDGSKIVFESDRSGSQQIYIMNADGSNQ--------NRISfgsgryATPVWSPRGDLIAF-TKLGGGFHVGVMK 388
Cdd:PRK01029 284 GNPSFSPDGTRLVFVSNKDGRPRIYIMQIDPEGQsprlltkkYRNS------SCPAWSPDGKKIAFcSVIKGVRQICVYD 357

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461903  389 -TDGSGEQILTNGWQDEGPSWSPNGRVIAFfrTARNSGHTELWSVDLTGVNERHIPTPL-DGSDPSWG 454
Cdd:PRK01029 358 lATGRDYQLTTSPENKESPSWAIDSLHLVY--SAGNSNESELYLISLITKKTRKIVIGSgEKRFPSWG 423
TolB_N pfam04052
TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent ...
 42-155 1.21e-27

TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.


Pssm-ID: 461148  Cd Length: 105  Bit Score: 105.78  E-value: 1.21e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903    42 LRVDITGGISQPMPIAVPVMPTPSSVEtlagttavLGRQVASVISNDLKSSGLFTPSQQASLhnVSFP-EVTAPQYSYWL 120
Cdd:pfam04052   1 LRIEITGGGDTALPIAVVPFQGEGGAD--------LPQDISEVIAADLERSGLFRPIDPAAF--PQRPtSDSEVDFADWR 70

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 67461903   121 SSGAQALVQGFVQANGDGTLTVGCYLYDVFASQEM 155
Cdd:pfam04052  71 ALGADALVTGSVTRGGDGRYKVEFRLYDVVKGKQL 105
 
Name Accession Description Interval E-value
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 32-454 0e+00

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 512.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903    32 AANQGDNRRILRVDITGGISQPMPIAVPVMPTPSSVetlaGTTAVLGRQVASVISNDLKSSGLFTPSQQASL-HNVSFPE 110
Cdd:TIGR02800   1 LAVSTPAAADLTIEITKGGASALPIAVAPFSNDGGG----SPDANLGESIAEVIANDLKRSGLFSPVDKAGLpSNPIAES 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   111 vtAPQYSYWLSSGAQALVQGFVQANGDGTLTVGCYLYDVFASQEML-HKGFVVKPADWRRAAHKCADAVYTRLTGEGPYF 189
Cdd:TIGR02800  77 --QVNPAAWQALGADALVVGSVTPNGNGRYTVRFRLYDVVSGQLQLlGKQYTVTASQLRRVAHRIADAIYEKLTGERGAF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   190 DSRIVYISETGpkNHRLKRLAIMDQDGANHRFLTNGQSMVLTPRFAPNQQTVTYLSYVGNSPRIYVYTLGSGHVRLVVNK 269
Cdd:TIGR02800 155 STRIAYVSKSG--KSRRYELQVADYDGANPQTITRSREPILSPAWSPDGQKLAYVSFESGKPEIYVQDLATGQREKVASF 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   270 PNTTFAPRFSPDGKTIVFSMSVAGNTDIYKVPVSGGQATRLTTSPGIDTAPSFSPDGSKIVFESDRSGSQQIYIMNADGS 349
Cdd:TIGR02800 233 PGMNGAPAFSPDGSKLAVSLSKDGNPDIYVMDLDGKQLTRLTNGPGIDTEPSWSPDGKSIAFTSDRGGSPQIYMMDADGG 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   350 NQNRISFGSGRYATPVWSPRGDLIAFTKL-GGGFHVGVMKTDGSGEQILTNGWQDEGPSWSPNGRVIAFFRTARNSGhte 428
Cdd:TIGR02800 313 EVRRLTFRGGYNASPSWSPDGDLIAFVHReGGGFNIAVMDLDGGGERVLTDTGLDESPSFAPNGRMILYATTRGGRG--- 389

                         410       420
                  ....*....|....*....|....*...
gi 67461903   429 LWSVDLTGVNERHIPTPLDG--SDPSWG 454
Cdd:TIGR02800 390 VLGLVSTDGRFRARLPLGNGdvREPAWS 417
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 285-441 6.37e-59

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 190.65  E-value: 6.37e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903 285 IVFSMSVAGNTDIYKVPVSGGQATRLTTSPGIDTAPSFSPDGSKIVFESDRSGSQQIYIMNADGSNQNRISFGSGRYATP 364
Cdd:COG0823   1 LAFTLSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461903 365 VWSPRGDLIAFTKL-GGGFHVGVMKTDGSGEQILTNGWQdeGPSWSPNGRVIAFFRTArnSGHTELWSVDLTGVNERH 441
Cdd:COG0823  81 SWSPDGKRLAFVSRsDGRFDIYVLDLDGGAPRRLTDGPG--SPSWSPDGRRIVFSSDR--GGRPDLYVVDLDGRKRRL 154
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 209-358 4.66e-35

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 127.87  E-value: 4.66e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903 209 LAIMDQDGANHRFLTNGQSMVLTPRFAPNQQTVTYLSYVGNSPRIYVYTLGSGHVRLVVNKPNTTFAPRFSPDGKTIVFS 288
Cdd:COG0823  13 IYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFV 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903 289 MSVAGNTDIYKVPVSGGQATRLTTSPGidtAPSFSPDGSKIVFESDRSGSQQIYIMNADGsNQNRISFGS 358
Cdd:COG0823  93 SRSDGRFDIYVLDLDGGAPRRLTDGPG---SPSWSPDGRRIVFSSDRGGRPDLYVVDLDG-RKRRLTPAS 158
tolB PRK01029
Tol-Pal system protein TolB;
168-454 1.35e-32

Tol-Pal system protein TolB;


Pssm-ID: 234889 [Multi-domain]  Cd Length: 428  Bit Score: 128.34  E-value: 1.35e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  168 RRAAHKCADAVYTRLTGEGPYFDSRIVYISETGPKNHRLKR--LAIMDQDGANHRFLTNGQSMVLTPRFAP--NQQTVTY 243
Cdd:PRK01029 124 RQKIHEAADTIHYALTGVPGISSGKIIFSLSTTNSDTELKQgeLWSVDYDGQNLRPLTQEHSLSITPTWMHigSGFPYLY 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  244 LSYVGNSPRIYVYTLGSGHVRLVVNKPNTTFAPRFSPDGKTIVFSMSVAGNTDIYKVPVS------GGQATRLTTSPGID 317
Cdd:PRK01029 204 VSYKLGVPKIFLGSLENPAGKKILALQGNQLMPTFSPRKKLLAFISDRYGNPDLFIQSFSletgaiGKPRRLLNEAFGTQ 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  318 TAPSFSPDGSKIVFESDRSGSQQIYIMNADGSNQ--------NRISfgsgryATPVWSPRGDLIAF-TKLGGGFHVGVMK 388
Cdd:PRK01029 284 GNPSFSPDGTRLVFVSNKDGRPRIYIMQIDPEGQsprlltkkYRNS------SCPAWSPDGKKIAFcSVIKGVRQICVYD 357

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67461903  389 -TDGSGEQILTNGWQDEGPSWSPNGRVIAFfrTARNSGHTELWSVDLTGVNERHIPTPL-DGSDPSWG 454
Cdd:PRK01029 358 lATGRDYQLTTSPENKESPSWAIDSLHLVY--SAGNSNESELYLISLITKKTRKIVIGSgEKRFPSWG 423
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 252-455 4.48e-29

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 120.91  E-value: 4.48e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  252 RIYVYTLGSGHVRLV---VNKPNTTFAPRF------------SPDGKTIVFSmsVAGntDIYKVPVSGGQATRLTTSPGI 316
Cdd:COG4946  268 DLYLLDLASGEPRKLnitLAGDFPQRRPRWvdvsgyltsfalSPDGKRVAFE--ARG--EVFTVPAEKGPTRNLTNTPGV 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  317 -DTAPSFSPDGSKIVFESDRSGSQQIYIMNADGSNQNR--ISFGSGRYATPVWSPRGDLIAFTKLGGGFHVgVMKTDGSG 393
Cdd:COG4946  344 rERLPAWSPDGKSIAYFSDASGEYELYIAPADGSGEPKqlTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWV-VDLASGKV 422

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461903  394 EQILTNGWQDE--GPSWSPNGRVIAFFRTARNsGHTELWSVDLTGvNERHIPTP--LDGSDPSWGP 455
Cdd:COG4946  423 RKVDTDGYGDGisDLAWSPDSKWLAYSKPGPN-QLSQIFLYDVET-GKTVQLTDgrYDDGSPAFSP 486
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 277-453 3.80e-28

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 118.22  E-value: 3.80e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  277 RFsPD--GKTIVFsmsVAGNtDIYKVPVSGGQATRLTTSPGIDTAPSFSPDGSKIVFESDRSGSQQIYIMNADGSNQNRI 354
Cdd:COG4946   26 RY-PAisGDTIVF---VYAG-DLWTVPADGGRARRLTSHPGYESFPRFSPDGKWIAFTSDYDGNTDVYVMPAEGGEPKRL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  355 SFGSGRYaTPV-WSPRGDLIAFTKLGGGFHVGVMK-----TDGSGEQILTNGWQDEGpSWSPNGRVIAF------FRTAR 422
Cdd:COG4946  101 TYHPAND-RVVgWTPDGKSVLFASNRGSPPSRSNQlytvpVDGGLPERLPLPPAGDG-SFSPDGKKLAYtrigreFRTWK 178

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 67461903  423 N---SGHTELWSVDLTGVNERHIpTPLDGSD--PSW 453
Cdd:COG4946  179 RyrgGTAGDIWIYDLGTGEFTRL-TDFGGNDrnPMW 213
TolB_N pfam04052
TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent ...
 42-155 1.21e-27

TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.


Pssm-ID: 461148  Cd Length: 105  Bit Score: 105.78  E-value: 1.21e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903    42 LRVDITGGISQPMPIAVPVMPTPSSVEtlagttavLGRQVASVISNDLKSSGLFTPSQQASLhnVSFP-EVTAPQYSYWL 120
Cdd:pfam04052   1 LRIEITGGGDTALPIAVVPFQGEGGAD--------LPQDISEVIAADLERSGLFRPIDPAAF--PQRPtSDSEVDFADWR 70

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 67461903   121 SSGAQALVQGFVQANGDGTLTVGCYLYDVFASQEM 155
Cdd:pfam04052  71 ALGADALVTGSVTRGGDGRYKVEFRLYDVVKGKQL 105
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 274-436 6.56e-25

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 108.20  E-value: 6.56e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  274 FAPRFSPDGKTIVFSMSVAGNTDIYKVPVSGGQATRLTTSPGIDTAPSFSPDGSKIVFESDR----SGSQQIYIMNADGS 349
Cdd:COG4946   64 SFPRFSPDGKWIAFTSDYDGNTDVYVMPAEGGEPKRLTYHPANDRVVGWTPDGKSVLFASNRgsppSRSNQLYTVPVDGG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  350 NQNRISFGSGRYATpvWSPRGDLIAFTKLGGGF-----HVGVMKTD------GSGE--QILTNGWQDEGPSWSpNGRVia 416
Cdd:COG4946  144 LPERLPLPPAGDGS--FSPDGKKLAYTRIGREFrtwkrYRGGTAGDiwiydlGTGEftRLTDFGGNDRNPMWI-GDRI-- 218

                        170       180
                 ....*....|....*....|
gi 67461903  417 FFRTARNsGHTELWSVDLTG 436
Cdd:COG4946  219 YFLSDRD-GTFNLYSYDPDG 237
tolB PRK04043
Tol-Pal system protein TolB;
232-417 2.48e-17

Tol-Pal system protein TolB;


Pssm-ID: 235212 [Multi-domain]  Cd Length: 419  Bit Score: 83.50  E-value: 2.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  232 PRFAPNQQTVTYL-SYVGNSPRIYVYTLGSGHVRLVVNKPNTTFAPRFSPDGKTIVFSMSVAGNTDIYKVPVSGGQATRL 310
Cdd:PRK04043 193 PKWANKEQTAFYYtSYGERKPTLYKYNLYTGKKEKIASSQGMLVVSDVSKDGSKLLLTMAPKGQPDIYLYDTNTKTLTQI 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  311 TTSPGIDTAPSFSPDGSKIVFESDRSGSQQIYIMNAD----------GSNQNRISfGSGRYAtpVWSPRGDLIAFTKlgG 380
Cdd:PRK04043 273 TNYPGIDVNGNFVEDDKRIVFVSDRLGYPNIFMKKLNsgsveqvvfhGKNNSSVS-TYKNYI--VYSSRETNNEFGK--N 347

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 67461903  381 GFHVGVMKTDGSGEQILTNGWQDEGPSWSPNGRVIAF 417
Cdd:PRK04043 348 TFNLYLISTNSDYIRRLTANGVNQFPRFSSDGGSIMF 384
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 192-337 7.15e-17

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 83.55  E-value: 7.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  192 RIVYISETGPKNHrlkrLAIMDQDGANH-RFLTNGQS-MVLTPRFAPNQqtvTYLSYVGNSPRIYVYTLGSGHVRLVVNK 269
Cdd:COG4946  356 SIAYFSDASGEYE----LYIAPADGSGEpKQLTLGDLgRVFNPVWSPDG---KKIAFTDNRGRLWVVDLASGKVRKVDTD 428

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67461903  270 PNT--TFAPRFSPDGKTIVFSMSVA-GNTDIYKVPVSGGQATRLTTSPGIDTAPSFSPDGSKIVFESDRSG 337
Cdd:COG4946  429 GYGdgISDLAWSPDSKWLAYSKPGPnQLSQIFLYDVETGKTVQLTDGRYDDGSPAFSPDGKYLYFLSSRDF 499
tolB PRK01029
Tol-Pal system protein TolB;
218-371 4.55e-15

Tol-Pal system protein TolB;


Pssm-ID: 234889 [Multi-domain]  Cd Length: 428  Bit Score: 76.72  E-value: 4.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  218 NHRFLTNGqsmvlTPRFAPNQQTVTYLSYVGNSPRIYVYTLG-SGHV-RLVVNKPNTTFAPRFSPDGKTIVFSMSVAGNT 295
Cdd:PRK01029 277 NEAFGTQG-----NPSFSPDGTRLVFVSNKDGRPRIYIMQIDpEGQSpRLLTKKYRNSSCPAWSPDGKKIAFCSVIKGVR 351

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461903  296 DIYKVPVSGGQATRLTTSPGIDTAPSFSPDGSKIVFESDRSGSQQIYIMNADGSNQNRISFGSGRYATPVWSPRGD 371
Cdd:PRK01029 352 QICVYDLATGRDYQLTTSPENKESPSWAIDSLHLVYSAGNSNESELYLISLITKKTRKIVIGSGEKRFPSWGAFPS 427
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 222-453 8.55e-15

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 77.00  E-value: 8.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  222 LTNGQSMVLTPRFAPNQQTVTYLS-YVGNsPRIYVYTLGSGHV-RLvvnkpntTFAPR------FSPDGKTIVFSMS--- 290
Cdd:COG4946   56 LTSHPGYESFPRFSPDGKWIAFTSdYDGN-TDVYVMPAEGGEPkRL-------TYHPAndrvvgWTPDGKSVLFASNrgs 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  291 -VAGNTDIYKVPVSGGQATRLTTSPGidTAPSFSPDGSKIVFE------------------------------------- 332
Cdd:COG4946  128 pPSRSNQLYTVPVDGGLPERLPLPPA--GDGSFSPDGKKLAYTrigrefrtwkryrggtagdiwiydlgtgeftrltdfg 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  333 ----------------SDRSGSQQIYIMNADGS------------------NQNRISF---------------------- 356
Cdd:COG4946  206 gndrnpmwigdriyflSDRDGTFNLYSYDPDGKdlrqlthfkdfdvrfpstDGGRIVYeqggdlylldlasgeprklnit 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  357 --GSGRYATPVW------------SPRGDLIAFTKLGGGFHVGVmkTDGSGEQiLTN--GWQDEGPSWSPNGRVIAFFRT 420
Cdd:COG4946  286 laGDFPQRRPRWvdvsgyltsfalSPDGKRVAFEARGEVFTVPA--EKGPTRN-LTNtpGVRERLPAWSPDGKSIAYFSD 362

                        330       340       350
                 ....*....|....*....|....*....|...
gi 67461903  421 ArnSGHTELWSVDLTGVNErhiPTPLDGSDPSW 453
Cdd:COG4946  363 A--SGEYELYIAPADGSGE---PKQLTLGDLGR 390
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 232-376 3.01e-13

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 71.99  E-value: 3.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903  232 PRFAPNQQTVTYLSYVGNSPRIYVYTL-GSGHVR-LVVNKPNTTFAPRFSPDGKTIVFsmsVAGNTDIYKVPVSGGQATR 309
Cdd:COG4946  348 PAWSPDGKSIAYFSDASGEYELYIAPAdGSGEPKqLTLGDLGRVFNPVWSPDGKKIAF---TDNRGRLWVVDLASGKVRK 424

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67461903  310 LTTSP--GIDTAPSFSPDGSKIVFE-SDRSGSQQIYIMNADGSNQNRISfgSGRYA--TPVWSPRGDLIAFT 376
Cdd:COG4946  425 VDTDGygDGISDLAWSPDSKWLAYSkPGPNQLSQIFLYDVETGKTVQLT--DGRYDdgSPAFSPDGKYLYFL 494
PD40 pfam07676
WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. ...
 308-343 3.12e-11

WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].


Pssm-ID: 429587 [Multi-domain]  Cd Length: 37  Bit Score: 57.91  E-value: 3.12e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 67461903   308 TRLTTSPGIDTAPSFSPDGSKIVFESDRSGSQQIYI 343
Cdd:pfam07676   2 GRLTNTPGNETAPSWSPDGKRLAFSSDRDGKPDIYV 37
PD40 pfam07676
WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. ...
 263-299 7.01e-06

WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].


Pssm-ID: 429587 [Multi-domain]  Cd Length: 37  Bit Score: 42.50  E-value: 7.01e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 67461903   263 VRLVVNKPNTTFAPRFSPDGKTIVFSMSVAGNTDIYK 299
Cdd:pfam07676   1 LGRLTNTPGNETAPSWSPDGKRLAFSSDRDGKPDIYV 37
WD40 COG2319
WD40 repeat [General function prediction only];
214-433 1.40e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 1.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903 214 QDGANHRFLTNGQSMVLTPRFAPNQQTVTYLSYVGnspRIYVYTLGSGHVRLVVNKPNTT-FAPRFSPDGKTIVfSMSVA 292
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG---TVRLWDLATGKLLRTLTGHSGAvTSVAFSPDGKLLA-SGSDD 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903 293 GNTDIYKVPvSGGQATRLTTSPGIDTAPSFSPDGSKIVfesdrSGS--QQIYIMNADGSNQNRISFGSGRYATPV-WSPR 369
Cdd:COG2319 184 GTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLA-----SGSadGTVRLWDLATGKLLRTLTGHSGSVRSVaFSPD 257

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67461903 370 GDLIAFTklGGGFHVGVMKTDGsGEQILTNGWQDEGP---SWSPNGRVIAffrTARNSGHTELWSVD 433
Cdd:COG2319 258 GRLLASG--SADGTVRLWDLAT-GELLRTLTGHSGGVnsvAFSPDGKLLA---SGSDDGTVRLWDLA 318
beta_prop_Msarc TIGR04275
beta propeller repeat, Methanosarcina surface protein type; This model describes a repeat ...
 308-345 1.04e-04

beta propeller repeat, Methanosarcina surface protein type; This model describes a repeat region found mostly in cell surface proteins of various methanogens. Methanosarcina barkeri, for example, has twenty such proteins, often with either seven or fourteen repeats. These repeats resemble the beta propeller repeats of the TolB periplasmic protein of Gram-negative bacteria, part of a complex associated with various functions including biopolymer transport (see TIGR02800).


Pssm-ID: 275097 [Multi-domain]  Cd Length: 40  Bit Score: 39.38  E-value: 1.04e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 67461903   308 TRLTTSPGIDTAPSFSpdGSKIVFESDRSGSQQIYIMN 345
Cdd:TIGR04275   2 TQITTDGSDQINPAIY--GDRVVWEDNRNGNWDIYMYD 37
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 254-452 1.08e-04

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 44.23  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   254 YVYTLGSGHVRLVVNKPNTTFAPRFSPDGKTIVFsmsVAGNtDIYKVPVSGGQATRLTTSP------------------G 315
Cdd:pfam00930  26 YIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAF---VRDN-NLYVRELATGKEIQITSDGsdgifngvadwvyeeevlG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   316 IDTAPSFSPDGSKIVFES--DRSGSQQIYIMNADGSNQNR-ISFgsgRYATPvwsprGDLIAFTKLG-----GGFHVGVM 387
Cdd:pfam00930 102 SNSAVWWSPDGSRLAFLRfdESEVPIITLPYYTDEGPGPEvREI---KYPKA-----GAPNPTVELFvydlaSGKTVEVV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   388 kTDGSGEQ---ILTNGwqdegpSWSPNGRViAFFRTARNSGHTELWSVDLTG--------------VNERHIPTPLDGSD 450
Cdd:pfam00930 174 -PPDDLSDadyYITRV------KWVPDGKL-LVQWLNRDQNRLKVVLCDAETgrtvvileetsdgwVELHQDPHFIKRDG 245


                  ..
gi 67461903   451 PS 452
Cdd:pfam00930 246 SG 247
DUF5050 pfam16472
Domain of unknown function (DUF5050);
194-436 1.92e-04

Domain of unknown function (DUF5050);


Pssm-ID: 465128 [Multi-domain]  Cd Length: 282  Bit Score: 43.00  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   194 VYISETGPKNhrlkRLAIMDQDGANHRFLTNGqsmvltprfapnqqTVTYLSYVGNspriYVYTLgsghvrlvvnKPNtt 273
Cdd:pfam16472  19 VYFSNPYDDG----RLYSMDSDGSNLKKLSDD--------------SVSYINVAGN----YIYYV----------RNN-- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   274 faprfspDGKTIVFSMSVAGNTDIYKVPVSGGQATRLTTSPGIDTAPSfspdGSKIVFES-DRSGSQQIYIMNADGSNQN 352
Cdd:pfam16472  65 -------DSKSTGGGFLRGSLTGLYRIKLDGTNRTKLDDDPSLYVSLY----GNYIYYQHyDNSDGGTLYKIKIDGKEKT 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   353 RISfgsgRYATPVWSPRGDLIAFTKLGGGFHVGVMKTDGSGEQILTNGWqdegpSWSPN--GRVIAFFRTARNsghTELW 430
Cdd:pfam16472 134 KLS----DEPISPASVSDGWIYYSGTSDDHYIYKLNTDGDSISKLYDGN-----SYMPNvnGDYIYYIDLSNN---YALY 201


                  ....*.
gi 67461903   431 SVDLTG 436
Cdd:pfam16472 202 RMNLSG 207
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 279-451 2.13e-04

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 43.46  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   279 SPDGKTIVFSM--------SVAGNTDIYkvPVSGGQATRLTTSPGIDTAPSFSPDGSKIVF--ESDrsgsqqIYIMNADG 348
Cdd:pfam00930   1 SPDGKYLLLATnytknwrhSYTADYYIY--DLETNRVEPLPPGEGKIQDAKWSPDGDRLAFvrDNN------LYVRELAT 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   349 SNQNRIsfgsgryatpvwsprgdliaftklgggfhvgvmkTDGSGEQILtNG---W--QDE------GPSWSPNGRVIAF 417
Cdd:pfam00930  73 GKEIQI----------------------------------TSDGSDGIF-NGvadWvyEEEvlgsnsAVWWSPDGSRLAF 117

                         170       180       190
                  ....*....|....*....|....*....|....
gi 67461903   418 FRtarnsghtelwsVDLTGVNERHIPTPLDGSDP 451
Cdd:pfam00930 118 LR------------FDESEVPIITLPYYTDEGPG 139
WD40 COG2319
WD40 repeat [General function prediction only];
214-433 3.54e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.51  E-value: 3.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903 214 QDGANHRFLTNGQSMVLTPRFAPNQQTvtyLSYVGNSPRIYVYTLGSGHVRLVVN-KPNTTFAPRFSPDGKTIVFSmSVA 292
Cdd:COG2319 192 ATGKLLRTLTGHTGAVRSVAFSPDGKL---LASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASG-SAD 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903 293 GNTDIYKVPvSGGQATRLTTSPGIDTAPSFSPDGSKIVfesdrSGS--QQIYIMNADGSNQNRISFGSGRYATPV-WSPR 369
Cdd:COG2319 268 GTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLA-----SGSddGTVRLWDLATGKLLRTLTGHTGAVRSVaFSPD 341

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67461903 370 GDLIAFTklGGGFHVGVMKTDGSGEQILTNGWQDE--GPSWSPNGRVIAffrTARNSGHTELWSVD 433
Cdd:COG2319 342 GKTLASG--SDDGTVRLWDLATGELLRTLTGHTGAvtSVAFSPDGRTLA---SGSADGTVRLWDLA 402
DUF5050 pfam16472
Domain of unknown function (DUF5050);
243-357 5.66e-03

Domain of unknown function (DUF5050);


Pssm-ID: 465128 [Multi-domain]  Cd Length: 282  Bit Score: 38.38  E-value: 5.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67461903   243 YLSYVGNSPRIYVYTLGSGHVRLVVNkpNTTFAPRFSPDgkTIVFsMSVAGNTDIYKVPVSGGQATRLTTspgiDTAPSF 322
Cdd:pfam16472 151 YYSGTSDDHYIYKLNTDGDSISKLYD--GNSYMPNVNGD--YIYY-IDLSNNYALYRMNLSGGEKEVLTD----DRVDNY 221

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 67461903   323 SPDGSKIVFESDrSGSQQIYIMNADGSNQNRISFG 357
Cdd:pfam16472 222 NVYGNWIYYQNN-GDDNKLYRINTDGSNKEKLAEG 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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