|
Name |
Accession |
Description |
Interval |
E-value |
| PRK04204 |
PRK04204 |
RNA 3'-terminal phosphate cyclase; |
2-337 |
0e+00 |
|
RNA 3'-terminal phosphate cyclase;
Pssm-ID: 235255 [Multi-domain] Cd Length: 343 Bit Score: 525.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 2 DFIVIDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSK 81
Cdd:PRK04204 1 RMIEIDGSYGEGGGQILRTALALSAITGKPFRITNIRANRPNPGLLRQHLTAVKAAAEICNAEVEGAELGSQELVFIPGP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 82 LSPKDFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPE 161
Cdd:PRK04204 81 IRGGDYRFDIGTAGSITLVLQTVLPALLFADGPSRVTITGGTDVPWAPPIDYIRRVTLPLLRRMGIEAEIELLRRGFYPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 162 GGGEVIFEVKPSKIKKFDLIEHSKSNLVEGISYVQNLDESIARRMRKKAVDLLNKEKLLPNI---KIECSKGISTGAGIV 238
Cdd:PRK04204 161 GGGEVALEVEPSKLRPLELLERGELLRIRGISHVANLPEHVAERQAKAAAELLALSLGLIEIeinVEELSRGLGPGSGIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 239 LW----NDTLGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAF--GKGIVGVSEITNHTKTNMWVV 312
Cdd:PRK04204 241 LWaeseHITEGFDALGERGKPAEVVGEEAAEELLRYLASGAAVDEHLADQLILPMALagGEGSFTVAELTSHLLTNIWVV 320
|
330 340
....*....|....*....|....*
gi 2500652 313 KHFLDVDFEIKEYkenncNGFTIEV 337
Cdd:PRK04204 321 EKFLPVKFEVEEY-----DGVVIKV 340
|
|
| RNA_3prim_cycl |
TIGR03399 |
RNA 3'-phosphate cyclase; Members of this protein family are RNA 3'-phosphate cyclase (6.5.1.4) ... |
4-321 |
2.84e-176 |
|
RNA 3'-phosphate cyclase; Members of this protein family are RNA 3'-phosphate cyclase (6.5.1.4), an enzyme whose function is conserved from E. coli to human. The modification this enzyme performs enables certain RNA ligations to occur, although the full biological roll for this enzyme is not fully described. This model separates this enzyme from a related protein, present only in eukaryotes, localized to the nucleolus, and involved in ribosomal modification. [Transcription, RNA processing]
Pssm-ID: 274563 [Multi-domain] Cd Length: 326 Bit Score: 491.40 E-value: 2.84e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 4 IVIDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLS 83
Cdd:TIGR03399 1 IEIDGSYGEGGGQILRTALSLSALTGKPVRIYNIRANRPKPGLAPQHLTAVKAAAEICNAEVEGAELGSTELEFIPGKIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 84 PKDFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGG 163
Cdd:TIGR03399 81 GGDYRFDIGTAGSVTLVLQTLLPALLFANGPSRVTVSGGTDVPWAPPVDYLRNVFLPLLERMGIRAELELLRRGFYPRGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 164 GEVIFEVKP-SKIKKFDLIEHSKSNLVEGISYVQNLDESIARRMRKKAVDLLNKEKLLPNIKIEC-SKGISTGAGIVLWN 241
Cdd:TIGR03399 161 GEVRLRVEPvKKLKPLELEERGELLRVSGIAHAANLPAHVAERMAKAAREELRKLGLDPEIEIEVlDKGLGPGSGIVLWA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 242 DT----LGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAF--GKGIVGVSEITNHTKTNMWVVKHF 315
Cdd:TIGR03399 241 ETehcrLGFSALGEKGKSAEKVGEEAAEQLLAELRSGAAVDEHLADQLILYMALasGESRFTTSELTMHLRTNIWVIEQF 320
|
....*.
gi 2500652 316 LDVDFE 321
Cdd:TIGR03399 321 LPVRFE 326
|
|
| RCL1 |
COG0430 |
RNA 3'-terminal phosphate cyclase [RNA processing and modification]; |
4-337 |
3.02e-173 |
|
RNA 3'-terminal phosphate cyclase [RNA processing and modification];
Pssm-ID: 440199 Cd Length: 340 Bit Score: 484.24 E-value: 3.02e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 4 IVIDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLS 83
Cdd:COG0430 2 IEIDGSYGEGGGQILRTALALSALTGKPVRITNIRAGRPKPGLRPQHLTAVKAAAEICGAEVEGAELGSTELTFRPGPVR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 84 PKDFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGG 163
Cdd:COG0430 82 GGDYRFDIGTAGSTTLVLQTLLPALALADGPSRLTLTGGTHVPWSPPFDYLERVFLPLLRRMGAEAELELLRRGFYPAGG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 164 GEVIFEVKPSK-IKKFDLIEHSKSNLVEGISYVQNLDESIARRMRKKAVDLLNKEKLLPNIKIECSKGISTGAGIVLW-- 240
Cdd:COG0430 162 GEVTLTVEPSAlLRPLDLLERGELLRVRGISLVANLPAHVAERQAEAARERLGEAGLEVEIEVEVRPALGPGSGIVLWae 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 241 --NDTLGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAF--GKGIVGVSEITNHTKTNMWVVKHFL 316
Cdd:COG0430 242 yeHGTEGFDALGERGKPAERVGEEAAEELLEFLASGAAVDEHLADQLLLPLALagGEGRFTVSELTDHLLTNIWVIEQFL 321
|
330 340
....*....|....*....|.
gi 2500652 317 DVDFEIKEYKEnncNGFTIEV 337
Cdd:COG0430 322 GVRIEVEGEEG---GPGRVTV 339
|
|
| RNA_Cyclase_Class_II |
cd00874 |
RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze ... |
6-324 |
1.09e-170 |
|
RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in all members of this subfamily.
Pssm-ID: 238446 [Multi-domain] Cd Length: 326 Bit Score: 477.10 E-value: 1.09e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 6 IDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLSPK 85
Cdd:cd00874 1 IDGSYGEGGGQILRTALALSAVTGKPVRIVNIRANRSNPGLSRQHLTAVRAAARICNAEVEGAELGSTELEFEPGKIKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 86 DFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGGGE 165
Cdd:cd00874 81 DYEFDIGTAGSITLVLQTLLPALLFADGPSTVTISGGTDVPWAPPIDYLRNVTLPLLERMGIEAELEVLRRGFYPRGGGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 166 VIFEVKPSKIKKFDLIEHSKSNL-VEGISYVQNLDESIARRMRKKAVDLLNKE-KLLPNIKIECSKGISTGAGIVLWNDT 243
Cdd:cd00874 161 VVLTVEPSKLLPPLLLEERGEIEkIRGISHAANLPPHVAERQAEAAAALLRKAlGLQIEIEPEDQSALGPGSGIVLWAEY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 244 ----LGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAF-GKGIVGVSEITNHTKTNMWVVKHFLDV 318
Cdd:cd00874 241 ehsrLGFSALGKKGVPAEKVGEEAAEELLAYLSSGAAVDEHLADQLIPFMALaGGSEFRTGELTLHLQTNIWVIEKFLGV 320
|
....*.
gi 2500652 319 DFEIKE 324
Cdd:cd00874 321 KFRIEE 326
|
|
| RTC |
pfam01137 |
RNA 3'-terminal phosphate cyclase; RNA cyclases are a family of RNA-modifying enzymes that are ... |
10-322 |
3.57e-150 |
|
RNA 3'-terminal phosphate cyclase; RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organizms. They catalyze the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids.
Pssm-ID: 460079 [Multi-domain] Cd Length: 324 Bit Score: 425.00 E-value: 3.57e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 10 YLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLSPKDFTI 89
Cdd:pfam01137 1 YGEGGGQILRTALALSALTGKPVRIENIRANRPKPGLRPQHLTAVRLLAKICNAEVEGAEIGSTELTFKPGTIKGGDYRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 90 DIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGGGEVIFE 169
Cdd:pfam01137 81 DIGTAGSITLVLQTLLPLLLFAKGPSTLTLRGGTNVPWAPSVDYLRTVFLPLLKRFGVDLELKILRRGFYPRGGGEVTLR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 170 VKPSKIKKFDLIEHSKSNLVEGISYVQNLDESIARRMRKKAVDLLNKEKLLPNIKIE---------CSKGISTGAGIVLW 240
Cdd:pfam01137 161 VEPSSLKPIQLLERGKVKRIRGIAYVARLPPSIANRMVAAAAGLLLRFLPDVYIITDvekgeesgkGGGGGIVLVAETTE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 241 NDTLGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAFGKG--IVGVSEITNHTKTNMWVVKHFLDV 318
Cdd:pfam01137 241 GCILGASALGERGKPAEDVGEEAAEELLEELESGGCVDEHLQDQLILFMALAGGesVFRTGPLTLHTITNIRVIEQFLGV 320
|
....
gi 2500652 319 DFEI 322
Cdd:pfam01137 321 KFKI 324
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK04204 |
PRK04204 |
RNA 3'-terminal phosphate cyclase; |
2-337 |
0e+00 |
|
RNA 3'-terminal phosphate cyclase;
Pssm-ID: 235255 [Multi-domain] Cd Length: 343 Bit Score: 525.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 2 DFIVIDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSK 81
Cdd:PRK04204 1 RMIEIDGSYGEGGGQILRTALALSAITGKPFRITNIRANRPNPGLLRQHLTAVKAAAEICNAEVEGAELGSQELVFIPGP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 82 LSPKDFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPE 161
Cdd:PRK04204 81 IRGGDYRFDIGTAGSITLVLQTVLPALLFADGPSRVTITGGTDVPWAPPIDYIRRVTLPLLRRMGIEAEIELLRRGFYPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 162 GGGEVIFEVKPSKIKKFDLIEHSKSNLVEGISYVQNLDESIARRMRKKAVDLLNKEKLLPNI---KIECSKGISTGAGIV 238
Cdd:PRK04204 161 GGGEVALEVEPSKLRPLELLERGELLRIRGISHVANLPEHVAERQAKAAAELLALSLGLIEIeinVEELSRGLGPGSGIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 239 LW----NDTLGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAF--GKGIVGVSEITNHTKTNMWVV 312
Cdd:PRK04204 241 LWaeseHITEGFDALGERGKPAEVVGEEAAEELLRYLASGAAVDEHLADQLILPMALagGEGSFTVAELTSHLLTNIWVV 320
|
330 340
....*....|....*....|....*
gi 2500652 313 KHFLDVDFEIKEYkenncNGFTIEV 337
Cdd:PRK04204 321 EKFLPVKFEVEEY-----DGVVIKV 340
|
|
| RNA_3prim_cycl |
TIGR03399 |
RNA 3'-phosphate cyclase; Members of this protein family are RNA 3'-phosphate cyclase (6.5.1.4) ... |
4-321 |
2.84e-176 |
|
RNA 3'-phosphate cyclase; Members of this protein family are RNA 3'-phosphate cyclase (6.5.1.4), an enzyme whose function is conserved from E. coli to human. The modification this enzyme performs enables certain RNA ligations to occur, although the full biological roll for this enzyme is not fully described. This model separates this enzyme from a related protein, present only in eukaryotes, localized to the nucleolus, and involved in ribosomal modification. [Transcription, RNA processing]
Pssm-ID: 274563 [Multi-domain] Cd Length: 326 Bit Score: 491.40 E-value: 2.84e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 4 IVIDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLS 83
Cdd:TIGR03399 1 IEIDGSYGEGGGQILRTALSLSALTGKPVRIYNIRANRPKPGLAPQHLTAVKAAAEICNAEVEGAELGSTELEFIPGKIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 84 PKDFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGG 163
Cdd:TIGR03399 81 GGDYRFDIGTAGSVTLVLQTLLPALLFANGPSRVTVSGGTDVPWAPPVDYLRNVFLPLLERMGIRAELELLRRGFYPRGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 164 GEVIFEVKP-SKIKKFDLIEHSKSNLVEGISYVQNLDESIARRMRKKAVDLLNKEKLLPNIKIEC-SKGISTGAGIVLWN 241
Cdd:TIGR03399 161 GEVRLRVEPvKKLKPLELEERGELLRVSGIAHAANLPAHVAERMAKAAREELRKLGLDPEIEIEVlDKGLGPGSGIVLWA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 242 DT----LGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAF--GKGIVGVSEITNHTKTNMWVVKHF 315
Cdd:TIGR03399 241 ETehcrLGFSALGEKGKSAEKVGEEAAEQLLAELRSGAAVDEHLADQLILYMALasGESRFTTSELTMHLRTNIWVIEQF 320
|
....*.
gi 2500652 316 LDVDFE 321
Cdd:TIGR03399 321 LPVRFE 326
|
|
| RCL1 |
COG0430 |
RNA 3'-terminal phosphate cyclase [RNA processing and modification]; |
4-337 |
3.02e-173 |
|
RNA 3'-terminal phosphate cyclase [RNA processing and modification];
Pssm-ID: 440199 Cd Length: 340 Bit Score: 484.24 E-value: 3.02e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 4 IVIDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLS 83
Cdd:COG0430 2 IEIDGSYGEGGGQILRTALALSALTGKPVRITNIRAGRPKPGLRPQHLTAVKAAAEICGAEVEGAELGSTELTFRPGPVR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 84 PKDFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGG 163
Cdd:COG0430 82 GGDYRFDIGTAGSTTLVLQTLLPALALADGPSRLTLTGGTHVPWSPPFDYLERVFLPLLRRMGAEAELELLRRGFYPAGG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 164 GEVIFEVKPSK-IKKFDLIEHSKSNLVEGISYVQNLDESIARRMRKKAVDLLNKEKLLPNIKIECSKGISTGAGIVLW-- 240
Cdd:COG0430 162 GEVTLTVEPSAlLRPLDLLERGELLRVRGISLVANLPAHVAERQAEAARERLGEAGLEVEIEVEVRPALGPGSGIVLWae 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 241 --NDTLGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAF--GKGIVGVSEITNHTKTNMWVVKHFL 316
Cdd:COG0430 242 yeHGTEGFDALGERGKPAERVGEEAAEELLEFLASGAAVDEHLADQLLLPLALagGEGRFTVSELTDHLLTNIWVIEQFL 321
|
330 340
....*....|....*....|.
gi 2500652 317 DVDFEIKEYKEnncNGFTIEV 337
Cdd:COG0430 322 GVRIEVEGEEG---GPGRVTV 339
|
|
| RNA_Cyclase_Class_II |
cd00874 |
RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze ... |
6-324 |
1.09e-170 |
|
RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in all members of this subfamily.
Pssm-ID: 238446 [Multi-domain] Cd Length: 326 Bit Score: 477.10 E-value: 1.09e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 6 IDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLSPK 85
Cdd:cd00874 1 IDGSYGEGGGQILRTALALSAVTGKPVRIVNIRANRSNPGLSRQHLTAVRAAARICNAEVEGAELGSTELEFEPGKIKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 86 DFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGGGE 165
Cdd:cd00874 81 DYEFDIGTAGSITLVLQTLLPALLFADGPSTVTISGGTDVPWAPPIDYLRNVTLPLLERMGIEAELEVLRRGFYPRGGGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 166 VIFEVKPSKIKKFDLIEHSKSNL-VEGISYVQNLDESIARRMRKKAVDLLNKE-KLLPNIKIECSKGISTGAGIVLWNDT 243
Cdd:cd00874 161 VVLTVEPSKLLPPLLLEERGEIEkIRGISHAANLPPHVAERQAEAAAALLRKAlGLQIEIEPEDQSALGPGSGIVLWAEY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 244 ----LGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAF-GKGIVGVSEITNHTKTNMWVVKHFLDV 318
Cdd:cd00874 241 ehsrLGFSALGKKGVPAEKVGEEAAEELLAYLSSGAAVDEHLADQLIPFMALaGGSEFRTGELTLHLQTNIWVIEKFLGV 320
|
....*.
gi 2500652 319 DFEIKE 324
Cdd:cd00874 321 KFRIEE 326
|
|
| RTC |
pfam01137 |
RNA 3'-terminal phosphate cyclase; RNA cyclases are a family of RNA-modifying enzymes that are ... |
10-322 |
3.57e-150 |
|
RNA 3'-terminal phosphate cyclase; RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organizms. They catalyze the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids.
Pssm-ID: 460079 [Multi-domain] Cd Length: 324 Bit Score: 425.00 E-value: 3.57e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 10 YLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLSPKDFTI 89
Cdd:pfam01137 1 YGEGGGQILRTALALSALTGKPVRIENIRANRPKPGLRPQHLTAVRLLAKICNAEVEGAEIGSTELTFKPGTIKGGDYRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 90 DIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGGGEVIFE 169
Cdd:pfam01137 81 DIGTAGSITLVLQTLLPLLLFAKGPSTLTLRGGTNVPWAPSVDYLRTVFLPLLKRFGVDLELKILRRGFYPRGGGEVTLR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 170 VKPSKIKKFDLIEHSKSNLVEGISYVQNLDESIARRMRKKAVDLLNKEKLLPNIKIE---------CSKGISTGAGIVLW 240
Cdd:pfam01137 161 VEPSSLKPIQLLERGKVKRIRGIAYVARLPPSIANRMVAAAAGLLLRFLPDVYIITDvekgeesgkGGGGGIVLVAETTE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 241 NDTLGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAFGKG--IVGVSEITNHTKTNMWVVKHFLDV 318
Cdd:pfam01137 241 GCILGASALGERGKPAEDVGEEAAEELLEELESGGCVDEHLQDQLILFMALAGGesVFRTGPLTLHTITNIRVIEQFLGV 320
|
....
gi 2500652 319 DFEI 322
Cdd:pfam01137 321 KFKI 324
|
|
| RNA_Cyclase |
cd00295 |
RNA 3' phosphate cyclase domain - RNA phosphate cyclases are enzymes that catalyze the ... |
6-324 |
5.88e-46 |
|
RNA 3' phosphate cyclase domain - RNA phosphate cyclases are enzymes that catalyze the ATP-dependent conversion of 3'-phosphate at the end of RNA into 2', 3'-cyclic phosphodiester bond. The enzymes are conserved in eucaryotes, bacteria and archaea. The exact biological role of this enzyme is unknown, but it has been proposed that it is likely to function in cellular RNA metabolism and processing. RNA phosphate cyclase has been characterized in human (with at least three isozymes), and E. coli, and it seems to be taxonomically widespread. The crystal structure of RNA phospate cyclase shows that it consists of two domains. The larger domain contains three repeats of a fold originally identified in the bacterial translation initiation factor IF3.
Pssm-ID: 238183 [Multi-domain] Cd Length: 338 Bit Score: 159.44 E-value: 5.88e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 6 IDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLSPK 85
Cdd:cd00295 1 LDGAKGEGGCEILRHALSLAMISGQPFRIEGIRADEADPGLKDQHLSALKAAEEICGASVEEAELGGQRFIFRPGNIIGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 86 DFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGGGE 165
Cdd:cd00295 81 DVRFACGSAGGCGLFLEPILIACLFADGPSRLELSGGTDNNEAIGADFIRRSLEPLLAKIFIHGDELELRHGFRGAAGGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 166 VIFEVKP-SKIKKFDLIEHSKSNLV----EGISYVQNLDESIARRMRKKAVDLLNKEK----LLPNIKIECSKGISTGAG 236
Cdd:cd00295 161 GAEENFLcASFKELLLGERGSEFGRqfrgEGIAAGTRVPPAFAEREIASAAGSFNLFEpdifILPDDQRGDECGNGPGNS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 237 IVLWNDTLGGSC-----LGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQ-IIPFLAFGKG----IVGVSEITNHTK 306
Cdd:cd00295 241 ISLEAESEKGCSeaaehCGEAGESAEDVAAFCAKELKEVIASGAAVDEYLADQlLLGMALAGEAgefiVAGPLCHLLQLT 320
|
330
....*....|....*...
gi 2500652 307 TNMWVVKHFLDVDFEIKE 324
Cdd:cd00295 321 NFARDVEAFFNCEFRFIE 338
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|
| 18S_RNA_Rcl1p |
TIGR03400 |
18S rRNA biogenesis protein RCL1; Members of this strictly eukaryotic protein family are not ... |
24-335 |
1.44e-33 |
|
18S rRNA biogenesis protein RCL1; Members of this strictly eukaryotic protein family are not RNA 3'-phosphate cyclase (6.5.1.4), but rather a homolog with a distinct function, found in the nucleolus and required for ribosomal RNA processing. Homo sapiens has both a member of this RCL (RNA terminal phosphate cyclase like) family and EC 6.5.1.4, while Saccharomyces has a member of this family only.
Pssm-ID: 274564 [Multi-domain] Cd Length: 360 Bit Score: 126.95 E-value: 1.44e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 24 LSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLSPKDFTIDIGTAGSISLVIQT 103
Cdd:TIGR03400 15 LSTLSGKPVRITKIRSDDENPGLRDYEVSFLRLLEKVTNGSKIEISYTGTTVIYKPGLITGGSVTHECPTSRGIGYYLEP 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 104 LLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLT---ELKVLKRGFYPEGGGEVIFEVKPSK-IKKFD 179
Cdd:TIGR03400 95 LLLLAPFSKKPLSITLKGITNSTGDPSVDTIRTATLPLLKKFGIPDeglELKILKRGAPPLGGGEVELRCPVIKqLKTIH 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 180 LIEHSKSNLVEGISYVQNLDESIARRMRKKAVDLLNkeKLLPNIKI--ECSKGI----STGAGIVLWNDTLGGSCL---- 249
Cdd:TIGR03400 175 LTERGRVKRIRGVAYSTRVSPSLANRMIDAARGVLN--NLLPDVYIttDVWKGKnsgkSPGYGLSLVAETTNGCIIsaea 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 250 ----GEKGLrAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAFGKGIVG---VSEITNHTKTNMWVVKHFLDVDFEI 322
Cdd:TIGR03400 253 vsspGEPSL-PEDLGKRAAYLLLEEIYKGGCVDSTHQPLALLLMALGQEDVSklrLGKLSEYTVEFLRDIKEFFGVTFKL 331
|
330
....*....|...
gi 2500652 323 KEYKENNCNGFTI 335
Cdd:TIGR03400 332 KDDKSDNGSGKVL 344
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|
| RNA_Cyclase_Class_I |
cd00875 |
RNA 3' phosphate cyclase domain (class I) This subfamily of cyclase-like proteins are encoded ... |
13-297 |
2.84e-27 |
|
RNA 3' phosphate cyclase domain (class I) This subfamily of cyclase-like proteins are encoded in eukaryotic genomes. They lack a conserved catalytic histidine residue required for cyclase activity, so probably do not function as cyclases. They are believed to play a role in ribosomal RNA processing and assembly.
Pssm-ID: 238447 [Multi-domain] Cd Length: 341 Bit Score: 109.32 E-value: 2.84e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 13 GGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLSPKDFTIDIG 92
Cdd:cd00875 8 KGSNFFRQRLVLATLSGKPIIIKKIRSDDTNPGLRDHEVSFLRLLEKVTNGSVIEISYTGTTLIYKPGLITGGVLNHDCP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 93 TAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLT---ELKVLKRGFYPEGGGEVIFE 169
Cdd:cd00875 88 VSRGIGYFLEPLLLLAPFGKKPLSITLKGITNSTGDPSVDSIRTATLPLLKKFGIPDeelELKILKRGVAPGGGGEVGFR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 170 V---KPSKIKKFDLIEHSKSnlVEGISYVQNLDESIARRMRKKAVDLLNkeKLLPNIKIEC------SKGISTGAGIVLW 240
Cdd:cd00875 168 CpvrKPLTPHLNDSPGRIKR--IRGVAYSTRVSPSIANRMIDAARGVLN--PFIPDVYIYTdvrkgdNSGKSPGFGISLV 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2500652 241 NDTLGGSCL--------GEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAFGKGIVG 297
Cdd:cd00875 244 AETTTGVLYsaenvspaGGESEVPEDLGRECAYQLLEEISRGGCVDSYQQPLALLLMALGSEDVG 308
|
|
| EPT_RTPC-like |
cd01553 |
This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate ... |
6-184 |
1.71e-26 |
|
This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a 4th slightly different domain inserted between the 2nd and 3rd repeat. They evidently share the same active site location, although the catalytic residues differ.
Pssm-ID: 238794 Cd Length: 211 Bit Score: 104.28 E-value: 1.71e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 6 IDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNAEVFGLNVGSEELTFIPSKLSPK 85
Cdd:cd01553 1 LDGAGGKGGGQILRSFLVLAAISGGPITVTGIRPDRAKPGLLRQHLTFLKALEKICGATVEGGELGSDRISFRPGTVRGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 86 DFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGTDVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGGGE 165
Cdd:cd01553 81 DVRFAIGSAGSCTDVLQTILPLLLFAKGPTRLTVTGGTDNPSAPPADFIRFVLEPELAKIGAHQEETLLRHGFYPAGGGV 160
|
170
....*....|....*....
gi 2500652 166 VIFEVKPSKIKKFDLIEHS 184
Cdd:cd01553 161 VATEVSPVEKLNTAQLRQL 179
|
|
| RTC_insert |
pfam05189 |
RNA 3'-terminal phosphate cyclase (RTC), insert domain; RNA cyclases are a family of ... |
189-270 |
1.58e-18 |
|
RNA 3'-terminal phosphate cyclase (RTC), insert domain; RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organizms. They catalyze the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids.
Pssm-ID: 461577 [Multi-domain] Cd Length: 102 Bit Score: 79.52 E-value: 1.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500652 189 VEGISYVQNLDESIARRMRKKAVDLLNKekLLPNIKIE-------CSKGISTGAGIVLWNDT-----LGGSCLGEKGLRA 256
Cdd:pfam05189 9 IRGVAYVAGLPPHVAERMAEAAREVLNK--LLPDVYIYidvvvegRDSGKGPGSGIVLVAETttgciLGADALGERGVPA 86
|
90
....*....|....
gi 2500652 257 EIVAERAVNELLKE 270
Cdd:pfam05189 87 EDVGEEAAEELLEE 100
|
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