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Conserved domains on  [gi|341940421|sp|Q61476|]
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RecName: Full=Complement decay-accelerating factor transmembrane isoform; Short=DAF-TM; AltName: CD_antigen=CD55; Flags: Precursor

Protein Classification

beta-2-glycoprotein 1( domain architecture ID 12867676)

beta-2-glycoprotein 1 is a heavily glycosylated plasma membrane-adhesion protein, which plays a role in blood coagulation and removal of apoptotic bodies

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 99-286 1.20e-35

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 131.70  E-value: 1.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  99 CEKSCDT----PERLSFASLKKEYFNMNFfPVGTIVEYECRPGFRKQPSLSGKSTCLEDlVWSPVAQfCKKKSCPNPKDL 174
Cdd:PHA02927  16 CVLSCCTipsrPINMKFKNSVETDANANY-NIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ-CIKRRCPSPRDI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 175 DNGHINIpTGILFGSEINFSCNPGYRLVGITSILCTI--IGNTVdWDDEFPVCTEIFCPDPPKINNGIMRGESDSYKYSQ 252
Cdd:PHA02927  93 DNGQLDI-GGVDFGSSITYSCNSGYQLIGESKSYCELgsTGSMV-WNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGS 170

                        170       180       190
                 ....*....|....*....|....*....|....
gi 341940421 253 VVIYSCDKGFILFGNSTIYCTvsksdVGQWSSPP 286
Cdd:PHA02927 171 VVTYSCNSGYSLIGNSGVLCS-----GGEWSDPP 199
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 41-100 2.75e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.55  E-value: 2.75e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  41 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFCE 100
Cdd:cd00033    1 CPPPPVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 99-286 1.20e-35

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 131.70  E-value: 1.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  99 CEKSCDT----PERLSFASLKKEYFNMNFfPVGTIVEYECRPGFRKQPSLSGKSTCLEDlVWSPVAQfCKKKSCPNPKDL 174
Cdd:PHA02927  16 CVLSCCTipsrPINMKFKNSVETDANANY-NIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ-CIKRRCPSPRDI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 175 DNGHINIpTGILFGSEINFSCNPGYRLVGITSILCTI--IGNTVdWDDEFPVCTEIFCPDPPKINNGIMRGESDSYKYSQ 252
Cdd:PHA02927  93 DNGQLDI-GGVDFGSSITYSCNSGYQLIGESKSYCELgsTGSMV-WNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGS 170

                        170       180       190
                 ....*....|....*....|....*....|....
gi 341940421 253 VVIYSCDKGFILFGNSTIYCTvsksdVGQWSSPP 286
Cdd:PHA02927 171 VVTYSCNSGYSLIGNSGVLCS-----GGEWSDPP 199
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 230-290 1.10e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 70.95  E-value: 1.10e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 341940421 230 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQCI 290
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN----GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 230-289 2.98e-13

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 64.08  E-value: 2.98e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421   230 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQC 289
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN----GTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
230-289 2.50e-12

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 61.36  E-value: 2.50e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  230 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQC 289
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED----GTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 41-100 2.75e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.55  E-value: 2.75e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  41 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFCE 100
Cdd:cd00033    1 CPPPPVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 41-99 1.08e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.99  E-value: 1.08e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 341940421    41 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 99
Cdd:smart00032   1 CPPPPDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIG--SSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
41-99 1.11e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.26  E-value: 1.11e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 341940421   41 CGPPPDIPNARPIlGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 99
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 99-286 1.20e-35

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 131.70  E-value: 1.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  99 CEKSCDT----PERLSFASLKKEYFNMNFfPVGTIVEYECRPGFRKQPSLSGKSTCLEDlVWSPVAQfCKKKSCPNPKDL 174
Cdd:PHA02927  16 CVLSCCTipsrPINMKFKNSVETDANANY-NIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ-CIKRRCPSPRDI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 175 DNGHINIpTGILFGSEINFSCNPGYRLVGITSILCTI--IGNTVdWDDEFPVCTEIFCPDPPKINNGIMRGESDSYKYSQ 252
Cdd:PHA02927  93 DNGQLDI-GGVDFGSSITYSCNSGYQLIGESKSYCELgsTGSMV-WNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGS 170

                        170       180       190
                 ....*....|....*....|....*....|....
gi 341940421 253 VVIYSCDKGFILFGNSTIYCTvsksdVGQWSSPP 286
Cdd:PHA02927 171 VVTYSCNSGYSLIGNSGVLCS-----GGEWSDPP 199
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 230-290 1.10e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 70.95  E-value: 1.10e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 341940421 230 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQCI 290
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN----GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 230-289 2.98e-13

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 64.08  E-value: 2.98e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421   230 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQC 289
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN----GTWSPPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 103-295 7.00e-13

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 68.54  E-value: 7.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 103 CDTPERLSFASLKKEyfnMNFFPVGTIVEYECRPGFrkqpSLSGKS--TCLED---LVWSPVAQFCKKKSCPNPKDLDNG 177
Cdd:PHA02639  22 CDKPDDISNGFITEL---MEKYEIGKLIEYTCNTDY----ALIGDRfrTCIKDknnAIWSNKAPFCMLKECNDPPSIING 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 178 HI-NIPTGILFGSEINFSCNP----GYRLVGITSILCTiigNTVDWDDEFPVCTEIFCpDPPKINNGIMRG--ESDSYKY 250
Cdd:PHA02639  95 KIyNKREMYKVGDEIYYVCNEhkgvQYSLVGNEKITCI---QDKSWKPDPPICKMINC-RFPALQNGYINGipSNKKFYY 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 341940421 251 SQVVIYSCDKGFILFGNSTIYCTVSKSdvgqWSSPPPQCIEESKV 295
Cdd:PHA02639 171 KTRVGFSCKSGFDLVGEKYSTCNINAT----WFPSIPTCVRNKPI 211
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 32-290 7.60e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 68.14  E-value: 7.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  32 LLFQTVCGDCGPPPDIPNARPILGrHSKFAeqSKVAYSCNNGFKQVpdksnivvclenGQWSSHetfcekscdtperlsf 111
Cdd:PHA02927  77 LFNQCIKRRCPSPRDIDNGQLDIG-GVDFG--SSITYSCNSGYQLI------------GESKSY---------------- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 112 aslkkeyfnmnffpvgtiveyeCRPGFRKQpslsgkstcledLVWSPVAQFCKKKSCPNPKDLDNG-HINIPTGILFGSE 190
Cdd:PHA02927 126 ----------------------CELGSTGS------------MVWNPEAPICESVKCQSPPSISNGrHNGYEDFYTDGSV 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 191 INFSCNPGYRLVGITSILCTiignTVDWDDEfPVCTEIFCPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTI 270
Cdd:PHA02927 172 VTYSCNSGYSLIGNSGVLCS----GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSS 246

                        250       260
                 ....*....|....*....|
gi 341940421 271 YCTVSKSdvgqWSSPPPQCI 290
Cdd:PHA02927 247 TCSPGNT----WQPELPKCV 262
Sushi pfam00084
Sushi repeat (SCR repeat);
230-289 2.50e-12

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 61.36  E-value: 2.50e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  230 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQC 289
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED----GTWSPPFPEC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 164-289 1.09e-11

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 65.07  E-value: 1.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 164 KKKSCPNPKDLDNGHIN-IPTGILFGSEINFSCNPGYRLVGITSILCTIIGNTVDWDDEFPVCTEIFCPDPPKINNGIMR 242
Cdd:PHA02639  18 KSIYCDKPDDISNGFITeLMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAIWSNKAPFCMLKECNDPPSIINGKIY 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 341940421 243 GESDSYKYSQVVIYSCD--KG--FILFGNSTIYCTVSKSdvgqWSSPPPQC 289
Cdd:PHA02639  98 NKREMYKVGDEIYYVCNehKGvqYSLVGNEKITCIQDKS----WKPDPPIC 144
PHA02831 PHA02831
EEV host range protein; Provisional
 130-293 1.57e-11

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 64.24  E-value: 1.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 130 VEYECRPGFRKQPSLSGKSTcledlvWSPVAQFCKKKSCPNPKDLDNGHI-NIPTGILFGSEINFSCNPG----YRLVGI 204
Cdd:PHA02831  46 LEYKCNNNFDKVFVTCNNGS------WSTKNMCIGKRNCKDPVTILNGYIkNKKDQYSFGDSVTYACKVNklekYSIVGN 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 205 TSILCTiignTVDWDDEFPVCTEIFCpDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSKSdvgqWSS 284
Cdd:PHA02831 120 ETVKCI----NKQWVPKYPVCKLIRC-KYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSI----WYP 190


                 ....*....
gi 341940421 285 PPPQCIEES 293
Cdd:PHA02831 191 GIPKCVKDK 199
PHA02817 PHA02817
EEV Host range protein; Provisional
 159-294 1.69e-10

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 60.72  E-value: 1.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 159 VAQFCKKKSCPNPKDLDNGHI-NIPTGILFGSEINFSCNPG-----YRLVGITSILCTIIGNtvdWDDEFPVCTEIFCpD 232
Cdd:PHA02817  15 VYSLCDLNKCCYPPSIKNGYIyNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGK---WNKEFPVCKIIRC-R 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 341940421 233 PPKINNGIMRGESDSYK--YSQVVIYSCDKGFILFGNSTIYCTVSKSdvgqWSSPPPQCIEESK 294
Cdd:PHA02817  91 FPALQNGFVNGIPDSKKfyYESEVSFSCKPGFVLIGTKYSVCGINSS----WIPKVPICSRDNI 150
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 41-100 2.75e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.55  E-value: 2.75e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  41 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFCE 100
Cdd:cd00033    1 CPPPPVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
PHA02831 PHA02831
EEV host range protein; Provisional
 60-227 3.89e-10

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 60.01  E-value: 3.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  60 FAEQSKVAYSCNNGFKQVpdksnIVVClENGQWSShETFC--EKSCDTPERLSFASLKKEyfnMNFFPVGTIVEYECRPG 137
Cdd:PHA02831  40 YEENENLEYKCNNNFDKV-----FVTC-NNGSWST-KNMCigKRNCKDPVTILNGYIKNK---KDQYSFGDSVTYACKVN 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 138 FRKQPSLSGKST--CLeDLVWSPVAQFCKKKSCPNPKdLDNGHINI-PTGILFGSEINFSCNPGYRLVGITSILCTIigN 214
Cdd:PHA02831 110 KLEKYSIVGNETvkCI-NKQWVPKYPVCKLIRCKYPA-LQNGFLNVfEKKFYYGDIVNFKCKKGFILLGSSVSTCDI--N 185

                        170
                 ....*....|...
gi 341940421 215 TVdWDDEFPVCTE 227
Cdd:PHA02831 186 SI-WYPGIPKCVK 197
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 168-225 2.49e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.91  E-value: 2.49e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 341940421   168 CPNPKDLDNGHIN-IPTGILFGSEINFSCNPGYRLVGITSILCTiigNTVDWDDEFPVC 225
Cdd:smart00032   1 CPPPPDIENGTVTsSSGTYSYGDTVTYSCDPGYTLIGSSTITCL---ENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 168-225 2.57e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 52.85  E-value: 2.57e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 341940421 168 CPNPKDLDNGHINIPTGI-LFGSEINFSCNPGYRLVGITSILCTIIGNtvdWDDEFPVC 225
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTITCTENGG---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 41-99 1.08e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.99  E-value: 1.08e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 341940421    41 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 99
Cdd:smart00032   1 CPPPPDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIG--SSTITCLENGTWSPPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 27-294 1.16e-08

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 56.25  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  27 VTIAVLLFQTVCGDCgPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPDKSnivVClENGQWSsHETFCEKSCDTP 106
Cdd:PHA02954   7 VTLLCVLPAVVYSTC-TVPTMNNAK-LTSTETSFNDKQKVTFTCDSGYYSLDPNA---VC-ETDKWK-YENPCKKMCTVS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 107 ERLSfaslkkEYFNMNFFPVGTIVEYECRPG---FRKQPSlsGKSTCLEDLVWSPVAQfCKkkscpnPKDLDNGHIN-IP 182
Cdd:PHA02954  80 DYVS------ELYDKPLYEVNSTITLICKDEtkyFRCEEK--NGNTSWNDTVTCPNAE-CQ------PLQLEHGSCQpVK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 183 TGILFGSEINFSCNPGYRLVGITSILCTIIGNTVdwddeFPVCTEIFcpDPPKINNGIMRGEsdSYKYSQVVIYSCDKGF 262
Cdd:PHA02954 145 EKYSFGEHITINCDVGYEVIGASYISCTANSWNV-----IPSCQQKC--DIPSLSNGLISGS--TFSIGGVIHLSCKSGF 215

                        250       260       270
                 ....*....|....*....|....*....|..
gi 341940421 263 ILFGNSTIYCTvsksdVGQWSSPPPQCIEESK 294
Cdd:PHA02954 216 TLTGSPSSTCI-----DGKWNPVLPICVRSNE 242
Sushi pfam00084
Sushi repeat (SCR repeat);
168-225 4.57e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.42  E-value: 4.57e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 341940421  168 CPNPKDLDNGHINIPTGI-LFGSEINFSCNPGYRLVGITSILCTIIGNtvdWDDEFPVC 225
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEyNYGASVSYECDPGYRLVGSPTITCQEDGT---WSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
103-163 6.13e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.03  E-value: 6.13e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 341940421  103 CDTPERLSFASLkkeYFNMNFFPVGTIVEYECRPGFRKQPSLsgKSTCLEDLVWSPVAQFC 163
Cdd:pfam00084   1 CPPPPDIPNGKV---SATKNEYNYGASVSYECDPGYRLVGSP--TITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
41-99 1.11e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.26  E-value: 1.11e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 341940421   41 CGPPPDIPNARPIlGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 99
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 103-164 5.00e-07

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 46.30  E-value: 5.00e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 341940421 103 CDTPERLSFASLKkeyFNMNFFPVGTIVEYECRPGFRKQPslSGKSTCLEDLVWSPVAQFCK 164
Cdd:cd00033    1 CPPPPVPENGTVT---GSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 103-163 3.41e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.36  E-value: 3.41e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 341940421   103 CDTPERLSFASLKKEYFNmnfFPVGTIVEYECRPGFRKQPSLSgkSTCLEDLVWSPVAQFC 163
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT---YSYGDTVTYSCDPGYTLIGSST--ITCLENGTWSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 115-227 1.88e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 42.62  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421 115 KKEYFNmnffpVGTIVEYECRPGFRKQP-SLSGKS--TCLEDLVWSPVAQFCKKKSCPNPKdLDNGHIN-IPTG--ILFG 188
Cdd:PHA02817  38 KKTEYN-----IGSNVTFFCGNNTRGVRyTLVGEKniICEKDGKWNKEFPVCKIIRCRFPA-LQNGFVNgIPDSkkFYYE 111

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 341940421 189 SEINFSCNPGYRLVGITSILCTIignTVDWDDEFPVCTE 227
Cdd:PHA02817 112 SEVSFSCKPGFVLIGTKYSVCGI---NSSWIPKVPICSR 147
PHA02831 PHA02831
EEV host range protein; Provisional
 40-170 2.55e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 39.21  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341940421  40 DCGPPPDIPNARpILGRHSKFAEQSKVAYSCN-NGFKQVPDKSNIVVCLENGQWSSHETFCEKScdtpeRLSFASLKK-- 116
Cdd:PHA02831  77 NCKDPVTILNGY-IKNKKDQYSFGDSVTYACKvNKLEKYSIVGNETVKCINKQWVPKYPVCKLI-----RCKYPALQNgf 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 341940421 117 -EYFNMNFFpVGTIVEYECRPGFRKQPSLSgkSTCLEDLVWSPVAQFCKKKSCPN 170
Cdd:PHA02831 151 lNVFEKKFY-YGDIVNFKCKKGFILLGSSV--STCDINSIWYPGIPKCVKDKVHN 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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