|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
21-436 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 744.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 21 DGGWGWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGL 100
Cdd:TIGR00892 13 DGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 101 LCCTGMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGW 180
Cdd:TIGR00892 93 LASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGW 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 181 KGSFLILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVGSRQDSSTKRLSKVSTAEKINRFLDFGLFTHRGFLIYLSGNVV 260
Cdd:TIGR00892 173 RGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKEGLPPDGSTKKLSKKSTAEKINRFLDFSLFTHRGFLVYLSGNVI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 261 LFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLAHS 340
Cdd:TIGR00892 253 MFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLTHLLCALAGD 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 341 YTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLS 420
Cdd:TIGR00892 333 YTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVS 412
|
410
....*....|....*.
gi 2316768857 421 SGIYLLICNAINYRLL 436
Cdd:TIGR00892 413 AGLFLAIGNYINYRLL 428
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
25-429 |
0e+00 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 552.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRPVGPspraakskskvgsrqdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPLGP--------------------------------------LFKHRGFLIYLSGNVIMFLG 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTAL 344
Cdd:cd17427 203 FFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 345 VVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGIY 424
Cdd:cd17427 283 VIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIW 362
|
....*
gi 2316768857 425 LLICN 429
Cdd:cd17427 363 LFIGN 367
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
25-427 |
1.27e-176 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 500.56 E-value: 1.27e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRPVGPSPraakskskvgsrqdsstkrlskvstaekinrFLDFGLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGPKP-------------------------------FLDLTLFTHRGFLLYLSGNVIMFFG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTAL 344
Cdd:cd17426 210 LFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGF 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 345 VVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGIY 424
Cdd:cd17426 290 CIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIY 369
|
...
gi 2316768857 425 LLI 427
Cdd:cd17426 370 LFI 372
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
25-429 |
1.92e-139 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 405.65 E-value: 1.92e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRPvgpspraakskskvgsrqdsstkrlskvstaekinrfLDFGLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP-------------------------------------LDFSVFRDRGFVIYTIAKFIMVLG 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTAL 344
Cdd:cd17430 204 LFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGGL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 345 VVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGIY 424
Cdd:cd17430 284 VVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALF 363
|
....*
gi 2316768857 425 LLICN 429
Cdd:cd17430 364 LALGN 368
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
25-427 |
4.38e-108 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 325.28 E-value: 4.38e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRpvgpspraakskskvgsrqdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR------------------------------------------LLKDPTFVLLALGVSFAMLG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANtsLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTAL 344
Cdd:cd17352 199 FFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAD--KPRIGRLYLYIFTLLILGLSLLAFPLATTYVGL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 345 VVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGIY 424
Cdd:cd17352 277 IVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVL 356
|
...
gi 2316768857 425 LLI 427
Cdd:cd17352 357 LFL 359
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
25-427 |
1.37e-104 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 316.71 E-value: 1.37e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRPvgpspraakskskvgsrqdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP-----------------------------------------FCSNTRYQIYTLGVTWMVLG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTAL 344
Cdd:cd17425 200 FVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 345 VVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGIY 424
Cdd:cd17425 280 LVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALF 359
|
...
gi 2316768857 425 LLI 427
Cdd:cd17425 360 MGL 362
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
25-425 |
1.71e-84 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 265.41 E-value: 1.71e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRPVGPSPRAAKskskvgsrqdsstkrlskvsTAEKINRFLDFGLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGDPPA--------------------PPRSLSAAFGLSLLTHRAFLRYALATTLINTG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPriQYLFSVAIMFTGICHLLCPLAHSYTAL 344
Cdd:cd17423 221 YFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTALTGLSLLLLPLAKVYGSL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 345 VVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLS-SGI 423
Cdd:cd17423 299 LALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLgSLI 378
|
..
gi 2316768857 424 YL 425
Cdd:cd17423 379 LL 380
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
25-425 |
2.36e-73 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 236.18 E-value: 2.36e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRpvgpspraakskskvgsrqdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17422 161 LVVGALQLNIVVCGALLR------------------------------------------VLKEPGFICYALFGLFATLG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRpRIQYLFSVAIMFtGICHLLCPLAHSYTAL 344
Cdd:cd17422 199 FFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIR-KIYIELICVILL-CVVLLLFPFAYGFWSL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 345 VVYVIFFGIGFGSISSLLFECLMDQ--VGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSG 422
Cdd:cd17422 277 LVCSIFYGFMFGTVAGTHIPLLAEDdvVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGA 356
|
...
gi 2316768857 423 IYL 425
Cdd:cd17422 357 VFL 359
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
25-425 |
1.51e-53 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 184.24 E-value: 1.51e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRpvgpspraakskskvgsrqdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17424 161 LILGGFVLNLCVCGALMR------------------------------------------FLLMPDFLVLAVSVLFLAYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTAL 344
Cdd:cd17424 199 CSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 345 VVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGIY 424
Cdd:cd17424 279 VPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLL 358
|
.
gi 2316768857 425 L 425
Cdd:cd17424 359 L 359
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
25-427 |
3.00e-50 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 175.40 E-value: 3.00e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFyRKRpLANGFAMAGSPVFLS-TLAPFNQFLFNSYGWKGS 183
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYF-KKR-LATAYAIARSGMGLTfALAPFTQLLLDEYDWQGA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 184 FLILGAIFLHSCVAGCLMRPVgpspraakskskvgsrqdsstkrlskvstaekinrflDFGLFTHRGFLIYLSGNVVLFL 263
Cdd:cd17421 159 LLIFGGIMLNLVASGMLLRPI-------------------------------------DFSLLKDPFFCIYTWSFVFSQL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 264 GMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRpriQYLFSVA-IMFTGICHLLCPLAHSYT 342
Cdd:cd17421 202 AYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIK---KYHYHKAyLILCGVTNLLAPLATTYP 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 343 ALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSG 422
Cdd:cd17421 279 LLMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSS 358
|
....*
gi 2316768857 423 IYLLI 427
Cdd:cd17421 359 VSFFL 363
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
25-425 |
1.60e-42 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 155.76 E-value: 1.60e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKT-----TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGG 99
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 100 LLCCTGMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYG 179
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 180 WKGSFLILGAIFLHSCVAGCLMRPVGPSPRAAKSKskvGSRQDSSTKRLSkvstaeKINRFLDFGLFTHRGFLIYLSGNV 259
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSK---PGRRTLHSRINL------FLRKIFNVEIFKRKRYVIWALGIP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 260 VLFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIqYLFSVAIMFTGICHLLCPLAH 339
Cdd:cd17420 232 LALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKM-YLQVLSFVSIGLMSMMIPLCN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 340 SYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVL 419
Cdd:cd17420 311 SFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPL 390
|
....*.
gi 2316768857 420 SSGIYL 425
Cdd:cd17420 391 IGSSLL 396
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
25-425 |
2.39e-35 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 135.69 E-value: 2.39e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFF----------NDIKDIFKTtssqiAWISSIMLAVMYAGGPISSVLVNNYGSRPV 94
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFvslleefgskDDAQMRFKT-----AWVGSLSMGMIFFCSPIVSVFTDLFGCRKT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 95 VIVGGLLCCTGMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFL 174
Cdd:cd17464 76 ATGGAAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 175 FNSYGWKGSFLILGAIFLHSCVAGCLMRPVGPSPRAAKSKskvgsrqdsstKRLSKVSTAEKInrfLDFGLFTHRGFLIY 254
Cdd:cd17464 156 LDSVGLFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGK-----------KRKFKCPPLKKI---FNFNIWKSTGYRIW 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 255 LSGNVVLFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIqYLFSVAIMFTGICHLL 334
Cdd:cd17464 222 AFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKV-YLQVSSFFFIGLMSMM 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 335 CPLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIAS 414
Cdd:cd17464 301 IPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLA 380
|
410
....*....|.
gi 2316768857 415 GIVVLSSGIYL 425
Cdd:cd17464 381 GVPPIIGGIIL 391
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
25-427 |
1.30e-34 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 133.03 E-value: 1.30e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRpvgpspraakskskvgsrqdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR------------------------------------------LFTNKVFVAFIFWALFAYCS 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDKGVDDYNSAF-LLSVMAFTDMFARPSVGLIANTSLIrpRIQYLFSVAIMFTGICHLLCPLAHSYT- 342
Cdd:cd17429 199 FVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCI--SVWNVFILANFTLGVCILILPLMHTYTg 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 343 -ALVVYVIFFGIGFGSISSLLFEclmDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSS 421
Cdd:cd17429 277 lAIVCALIGFSSGYFSLMPVVTE---DLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVG 353
|
....*.
gi 2316768857 422 GIYLLI 427
Cdd:cd17429 354 IICLLL 359
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
25-427 |
5.17e-31 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 123.00 E-value: 5.17e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRpvgpspraakskskvgsrqdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17428 161 LIVGALALNLLACGSLMR------------------------------------------LFKNRVFSALFIAILLFDIG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDKGVDDYNSAF-LLSVMAFTDMFARPSVGLIANTSLIRPriQYLFSVAIMFTGICHLLCPLAHSYTA 343
Cdd:cd17428 199 AFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNS--LYLYVLTLIGMGAALLAIPFAKSYLT 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 344 LVVYVIFFGIGFGSISSLLFeCLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGI 423
Cdd:cd17428 277 LAVLSAILGFLSGNWSIFPY-VTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGF 355
|
....
gi 2316768857 424 YLLI 427
Cdd:cd17428 356 LLLL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-428 |
1.41e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 119.60 E-value: 1.41e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 26 WVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTG 105
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 106 MILASFSSSvIELYLTVGFIGGLGLAFNLQPALTIIGKYFY-RKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:COG2223 84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILG-AIFLHSCVAGCLMRPVGPSPRAAKSKSKVGSRQdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFL 263
Cdd:COG2223 163 LILGiLLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE-----------------------ALRDPRFWLLSLLYFGTFG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 264 GMFAPIIFLAPYAKDK-GVDDYNSAFLLSVMAFTDMFARPSVGLIANtsLIRPRIQYLFSVAIMFTGIChLLCPLAHSYT 342
Cdd:COG2223 220 SFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSD--RIGGRRVLLIVFALMALGLL-LLALALGSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 343 ALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSG 422
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVAL 376
|
....*.
gi 2316768857 423 IYLLIC 428
Cdd:COG2223 377 VLTLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
22-427 |
1.74e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 118.82 E-value: 1.74e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 22 GGWGWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLL 101
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 102 CCTGMILASFSSSVIELYLTVgFIGGLGLAFNLQPALTIIGKYFYRK-RPLANGFAMAGSPVFLSTLAPFNQFLFNSYGW 180
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKeRGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 181 KGSFLILGAIFLhscVAGCLMrpvgpspraakskskvgsrqdsstkrlskvstaekinrfldfglfthrgFLIYLSGNVV 260
Cdd:COG2271 164 RAAFLILGLPGL---LLALLR-------------------------------------------------FWLLALAYFL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 261 LFLGMFAPIIFLAPYAKD-KGVDDYNSAFLLSVMAFTDMFARPSVGLIANtsLIRPRIQYLFSVAIMFTGICHLLCPLAH 339
Cdd:COG2271 192 VYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD--RLGRRRKLVLAIGLLLAALALLLLALLP 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 340 SYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVL 419
Cdd:COG2271 270 SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALL 349
|
....*...
gi 2316768857 420 SSGIYLLI 427
Cdd:COG2271 350 AALLALLL 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
26-385 |
1.63e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 104.29 E-value: 1.63e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 26 WVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTG 105
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 106 MILASFSSSVIELYLtVGFIGGLGLAFNLQPALTIIGKYF-YRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:COG2814 89 SLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVGSrqdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLG 264
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARLRGSLRE-------------------------LLRRPRLLLLLLLAFLLGFG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKDK-GVDDYNSAFLLSVMAFTDMFARPSVGLIANtsliRPRIQYLFSVAIMFTGICHLLCPLAHSYTA 343
Cdd:COG2814 223 FFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLAD----RFGRRRLLLIGLLLLALGLLLLALAGSLWL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2316768857 344 LVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIV 385
Cdd:COG2814 299 LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
25-426 |
4.55e-24 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 103.50 E-value: 4.55e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPA-LTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGS 183
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 184 FLILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVGSRQDSSTKRlskvstaekinrfldfGLFTHRGFLIYLSGNVVLFL 263
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLK----------------EALRSASFWLLALAFFLCGF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 264 GMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANtsLIRPRiqYLFSVAIMFTGICHLLCPLAH-SYT 342
Cdd:cd17355 225 AVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD--RYSPR--RLLAASYALRALGLALLLLLPfPPL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 343 ALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSG 422
Cdd:cd17355 301 ALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAA 380
|
....
gi 2316768857 423 IYLL 426
Cdd:cd17355 381 LLVL 384
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-394 |
1.04e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 101.73 E-value: 1.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 27 VVVCASFISIGFSYAFPkavtVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGM 106
Cdd:pfam07690 1 LFLAAFLAALGRSLLGP----ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 107 ILASFSSSVIELYLtVGFIGGLGLAFNLQPALTIIGKYFYRK-RPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSFL 185
Cdd:pfam07690 77 LLLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 186 ILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVGSrqdsstkrlskvstaekinRFLDFGLFTHRGFLIYLSGNVVLFLGM 265
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLS-------------------LIVAWKALLRDPVLWLLLALLLFGFAF 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 266 FAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIqYLFSVAIMFTGICHLLCPLAHSYTALV 345
Cdd:pfam07690 217 FGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL-LLALLLLILAALGLLLLSLTLSSLWLL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2316768857 346 VYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGP 394
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
45-430 |
4.00e-23 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 101.10 E-value: 4.00e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 45 AVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLTVGF 124
Cdd:COG2807 36 SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 125 IG-GLGLAFNLQPALtiIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSFLILGAIflhSCVAGCLMRP 203
Cdd:COG2807 116 IGaGIAVGNVLLPGL--IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALL---ALLALLLWLP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 204 VGPSPRAAKSKSKVGSRqdssTKRLSKVSTAekinrfldfglfthRGFLIYLSGNVVLFLGMFApiiFLAPYAKDKGVDD 283
Cdd:COG2807 191 LLRRRPAAAAAAPAAAS----LRSLWRSPLA--------------WLLTLFFGLQSLLYYAVVA---WLPPILRDAGLSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 284 YNSAFLLSVMAFTDMFARPSVGLIANtsliRPRIQYLFSVAIMFTGICHLLCPLAHSYTALVVYVIFFGIGFGSISSLLF 363
Cdd:COG2807 250 ATAGLLLSLFQLAGIPGSLLVPLLAD----RLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLAL 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2316768857 364 ECLMDQVGASRFSSAvgLVTIVECCPVL---FGPPLAGKLLDITGQYKY-LYIASGIVVLSSGIYLLICNA 430
Cdd:COG2807 326 TLIGLRARTPAEAAA--LSGMAQSVGYLlaaLGPLLVGALHDATGSWTAaLLLLAALAVLMLVAGLLAGRP 394
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
25-426 |
1.32e-21 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 96.33 E-value: 1.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIFLHSCVAGCLMRPVGPsPRAAKSKSKVGSRQDSSTkrlskvstaeKINRFLDFGLFthrgFLIYLSgnvvLFLG 264
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEP-PDNQARLHVQKKKTQTMG----------EIFRDKVFWIL----FIAIFL----VLIG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKD-KGVDDYNSAFLLSVMAFTDMFARPSVGLIANTsLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTA 343
Cdd:cd17314 222 GFLFIANMASLVRSlQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADF-FGGRLSTLSILLTILGLGLCAFLFLLKMTPVG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 344 LVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKY-LYIASGIVVLSSG 422
Cdd:cd17314 301 LVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISaVYIYAVIVFLASA 380
|
....
gi 2316768857 423 IYLL 426
Cdd:cd17314 381 ILLA 384
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
24-427 |
3.92e-21 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 94.98 E-value: 3.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 24 WGWVVVCasfISIGFSYAFpkavTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCC 103
Cdd:cd17353 7 LGAVLMH---LILGYQYAW----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 104 TGMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGS 183
Cdd:cd17353 80 LGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 184 FLILGAIFL-HSCVAGCLMRPvgpsPRAAKSKSKVGSRQDSSTKRLSKVSTAEKINrfldfglfTHRGFLIYLSgnvvLF 262
Cdd:cd17353 160 FLILGIIFLiIIVIGAFLIRD----PPKGWVPPGVDPLANNAENSPRDYTPREMLR--------TPTFWLLWLM----FF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 263 LGMFAPIIF---LAPYAKDK-GVDDYNSAFLLSVMAFTDMFARPSVGLIANtsliRPRIQYLFSVAIMFTGICHLLCPLA 338
Cdd:cd17353 224 LNATAGLMLigqAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWLSD----KIGRKNTLSIAFLIQGVAMFLLPFI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 339 -HSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGkLLDITGQYKYLYIASGIV 417
Cdd:cd17353 300 gSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAAL 378
|
410
....*....|
gi 2316768857 418 VLSSGIYLLI 427
Cdd:cd17353 379 SLVALALALL 388
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
25-426 |
7.13e-20 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 91.01 E-value: 7.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFI---SI-GFSYAFPKAVTVFFNDIKDIFKTTSS-QIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGG 99
Cdd:cd17465 1 GWVVVFAATWcngSIfGIQNSFGILYVMLLNEQEDQKDQAVQfKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 100 LLCCTGMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYG 179
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 180 WKGSFLILGAIFLhscvagclmrpvgpspraakskskvgsrqdsstkrlskvstaEKINRFLDFGLFTHRGFLIYLSGNV 259
Cdd:cd17465 161 LAHTFQVLSLFMF------------------------------------------IQIFLSLTYKVFRRKTYRIWAFGIA 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 260 VLFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANtSLIRPRIQYLFSVAIMFTGICHLLCPLAH 339
Cdd:cd17465 199 TAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGD-LIPGLKKIYLQVASFLLLGIMSMMIPLCQ 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 340 SYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVL 419
Cdd:cd17465 278 VFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPI 357
|
....*..
gi 2316768857 420 SSGIYLL 426
Cdd:cd17465 358 IGGTVLF 364
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-426 |
3.37e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 83.24 E-value: 3.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 29 VCASFISIGFSYAfpkAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMIL 108
Cdd:cd06174 1 LLLGFFLTGLARG---LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 109 ASFSSSVIELYLTvGFIGGLGLAFNLQPALTIIGKYFYRK-RPLANGFAMAGSPVFLSTLAPFNQFLF--NSYGWKGSFL 185
Cdd:cd06174 78 FAFAPSFWLLLLG-RFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 186 ILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVGSRQDSSTKRLSKVstaekinrfldfglfthRGFLIYLSGNVVLFLGM 265
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKN-----------------PGLWLLLLAIFLVNLAY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 266 FAPIIFLAPYAKDKGVDDY-NSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGIchlLCPLAHSYTAL 344
Cdd:cd06174 220 YSFSTLLPLFLLDLGGLSVaVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLA---LLLLAPSLLLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 345 VVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGIY 424
Cdd:cd06174 297 LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
..
gi 2316768857 425 LL 426
Cdd:cd06174 377 LL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
60-427 |
1.32e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 78.39 E-value: 1.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 60 TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLTVgFIGGLGLAFNLQPALT 139
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 140 IIGKYF-YRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSFLILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVG 218
Cdd:cd17325 108 LIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 219 SRQDSstkrlskvstaekinrfldFGLFTHRGFLIYLSGNVVLFLGMFAPIIFLAPYAKDK-GVDDYNSAFLLSVMAFTD 297
Cdd:cd17325 188 LRSGL-------------------RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 298 MFARPSVGLIANTsliRPRIQYLFSVAImFTGICHLLCPLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSS 377
Cdd:cd17325 249 ALSQPPAGKLSDR---IGRKPLILIGLL-LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGT 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2316768857 378 AVGLVTIVECCPVLFGPPLAGKLLDITGqYKYLYIASGIVVLSSGIYLLI 427
Cdd:cd17325 325 AMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
27-429 |
6.21e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.19 E-value: 6.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 27 VVVCASFISIGFSYAfpkAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGM 106
Cdd:COG0738 11 IAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 107 ILASFSSSVIeLYLTVGFIGGLGLAF---NLQPALTIIGKYFYRKR-PLANGFAMAGS---PVFLSTLApfnqFLFNSYG 179
Cdd:COG0738 88 LLFALAPSYP-LLLLALFLLGLGLGLldvAANPYVAALGPETAASRlNLLHAFFSLGAllgPLLGGLLI----LLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 180 WKGSFLILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVGSRqdsstkrlskvstaekinrfldFGLFTHRGFLIYLsgnV 259
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASL----------------------KSLLKNPRLLLGG---L 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 260 VLFLGMFA---PIIFLAPYAKD-KGVDDYNSAFLLSVMAFTDMFARPSVGLIANtsLIRPRIQYLFSVAIMFTGIchLLC 335
Cdd:COG0738 218 AIFLYVGAegaIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLLK--RFGPVRLLRLSALLAAVGL--LLA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 336 PLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRfSSAVGLVTIVECCPVLFGPPLAGKLLDITGqYKYLYIASG 415
Cdd:COG0738 294 LLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPL 371
|
410
....*....|....
gi 2316768857 416 IVVLSSGIYLLICN 429
Cdd:COG0738 372 VCYLLILLLALALK 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
52-362 |
7.30e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 66.80 E-value: 7.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 52 DIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSvIELYLTVGFIGGLGLA 131
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-FALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 132 FNLQPALTIIGKYF-YRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSFLILGAIFLhsCVAGCLMRPVGPSPRA 210
Cdd:cd17324 103 GFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL--LAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 211 AKSKSKVGSRQdsstkrlskvstaekinrfldFGLFTHRGFLIYLSGNVVLFLGMFAPIIFLAPYAKDK-GVDDYNSAFL 289
Cdd:cd17324 181 KPGSLGLLSSL---------------------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGL 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2316768857 290 LSVMAFTDMFARPSVGLIANTSLIRPriqyLFSVAIMFTGICHLLCPLAHSYTALVVYVIFFGIGFGSISSLL 362
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRA----LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAL 308
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
53-427 |
1.28e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 66.05 E-value: 1.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 53 IKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELyLTVGFIGGLGLAF 132
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 133 NLQPALTIIGKYF-YRKRP-------LANGFAMAGSPVFLSTLApfnqflfnSYGWKGSFLILGAIFLHSCVAgcLMRPV 204
Cdd:cd17474 104 LGPLALTLIGDLFeGGERAkamglyeAALGLGIAVGPLLGGLLA--------AISWRYPFFLLAALIPVAFLA--ILFLL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 205 GPSPRAAKSKSKVGSRQDSStkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLGMFAPIIFLAPYAKDKgvddy 284
Cdd:cd17474 174 PEPKEKAKSSSATKLRDLKK--------------------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELL----- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 285 nsaFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFS------VAIMFTGICHLLCPLAHSYTALVVYVIFFGIGFGSI 358
Cdd:cd17474 229 ---YGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGarrilvIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLN 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2316768857 359 SSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGIYLLI 427
Cdd:cd17474 306 LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
80-426 |
5.12e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.15 E-value: 5.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 80 PISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIeLYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRpLANGFAMAG 159
Cdd:cd17489 49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 160 SPVFLSTL--APFNQFLFNSYGWKGSFlILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVGSRQDSSTKRlskvstaeki 237
Cdd:cd17489 127 LATTLAMAlgPALGLFLYQHLGFAVLF-IVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK---------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 238 nrfldfglfthrgflIYLSGNVVLFLGM-FAPII-FLAPYAKDKGVDdyNSAFLLSVMAFTDMFARPSVGLIANTslIRP 315
Cdd:cd17489 196 ---------------VLPPALILFLASIaYGAIStFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDR--KGP 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 316 RIQYLFSVAIMFTGICHLLcpLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPP 395
Cdd:cd17489 257 KTVIIPGLLLLALGLLLLS--FAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGL 334
|
330 340 350
....*....|....*....|....*....|.
gi 2316768857 396 LAGKLLDITGqYKYLYIASGIVVLSSGIYLL 426
Cdd:cd17489 335 LLGLVAELFG-YRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
53-423 |
4.17e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.49 E-value: 4.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 53 IKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSvIELYLTVGFIGGLGLAf 132
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS-YPVLLVLLFLVGAGYG- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 133 NLQPALT--IIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSFLILGAI-FLHSCVAGCLMR-PVGPSP 208
Cdd:cd17475 100 SVQPGGGraIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVsILAAVLFWLFYRePPAASA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 209 RAAKSKSKVGSRQdsstkrlskvstaekinrfldfGLFTHRGFLIYLSGNVVLFLGMFAPIIFLAPYAKDK-GVDDYNSA 287
Cdd:cd17475 180 ATESASTLLRSLK----------------------EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSVVAAG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 288 FLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTALVVYVIFFGIGFGSIS--SLLFEC 365
Cdd:cd17475 238 ALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGwnGLYLTL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2316768857 366 LMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIA-SGIVVLSSGI 423
Cdd:cd17475 318 VAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLAlALLLVLAALL 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
246-427 |
1.09e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.91 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 246 FTHRGFLIYLSGNVVLFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANtsLIRPRIQYLFSVAI 325
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD--RFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 326 MftGICHLLCPLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITG 405
Cdd:COG2814 85 F--ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180
....*....|....*....|..
gi 2316768857 406 qYKYLYIASGIVVLSSGIYLLI 427
Cdd:COG2814 163 -WRWVFLVNAVLALLALLLLLR 183
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
24-312 |
1.36e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.97 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 24 WGWVVVCASFISIGFSYAfpkAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCC 103
Cdd:COG0477 14 RALLALALGTFLEGLDFT---IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 104 TGMILASFSSSVIELYLTVgFIGGLGLAFNLQPALTIIGKYF-YRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKG 182
Cdd:COG0477 91 LASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 183 SFLILGAIFLhscvAGCLMRPVGPSPRAAKSKSKVGSRQDSSTKRLSKVSTAEKINRFLDFGLFTHRGFLIYLSGNVVLF 262
Cdd:COG0477 170 IFLINAPLGL----LALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2316768857 263 LGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSL 312
Cdd:COG0477 246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
79-427 |
1.75e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.43 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 79 GPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSvIELYLTVGFIGGLGLAFNLQPALTIIGKYF---YRKRPLA--N 153
Cdd:cd17473 52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS-LYALLASRALLGIGVAGIMTLATALIGDYFegeERAKMLGlqS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 154 GFAMAGSPVFLS---TLApfnqflfnSYGWKGSFLI-LGAIFLHSCVAGCLMRPVgpspraakskskvgsRQDSSTKRLS 229
Cdd:cd17473 131 AAMSLGGVVFLLlggALA--------EIGWRAPFLVyLLALPVLILVLLFLPEPA---------------RKSKSAASPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 230 KVSTAEKINRfldfglfthRGFLIYLSGnVVLFLGMFAPIIFLAPYAKDKGVDDYNSA-FLLSVMAFTDMFARPSVGLIA 308
Cdd:cd17473 188 AATAAALPWK---------RVLPIYFLA-FLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 309 NtsLIRPRIQYLFSVAIMFTGicHLLCPLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVecc 388
Cdd:cd17473 258 R--RLGKRRLLAIGFALMALG--FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA--- 330
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2316768857 389 pVLFG----PPLAGKLLDITGQYKYLYIASGIVVLSSGIYLLI 427
Cdd:cd17473 331 -FFLGqflsPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
60-426 |
2.78e-08 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 55.77 E-value: 2.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 60 TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELyLTVGFIGGLGLAFNLQPALT 139
Cdd:cd06180 32 SYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAAL-LALRFLAGAASAFVFVFGSN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 140 IIGKYFY---RKRPLANGFAMAGSPVFLSTL-APFnqFLFNSYGWKGSFLILGAIFLHSCVAGCLMRPVGPSPRAAKSKS 215
Cdd:cd06180 111 LVLHHATaagRGHLIGLLFAGVGLGIALSGLlVPA--GLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 216 KVGSRQDSSTKRLskvstaekinrFLDFGLFthrGFliylsgnvvlflGMFAPIIFLAPYAKDKGVddyNSAFLLSVMAF 295
Cdd:cd06180 189 ESAPGLNRPLWRL-----------ALAYGLF---GF------------GYIITATFLPLIARETGA---GSLLAGLLWSL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 296 TDMFARPSVGLIANTSLIRPRIQyLFSVAIMFTGICHLLCPLAHSYTALVVYVIFFGIGFGSISSLLFEcLMDQVGASRF 375
Cdd:cd06180 240 FGLAAVPSCFLWGALSDRWGTRR-ALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMA-LARELAPPAA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2316768857 376 SSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKY-LYIASGIVVLSSGIYLL 426
Cdd:cd06180 318 PRALALMTASFGVGQILGPLLAGWLADATGGFAPaLILAAAALVVAALLALL 369
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
260-427 |
1.14e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 53.73 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 260 VLFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTslIRPRIQYLFSVAIMftGICHLLCPLAH 339
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDR--FGRKRLLLLGLLLL--AVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 340 SYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGqYKYLYIASGIVVL 419
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALAL 161
|
....*...
gi 2316768857 420 SSGIYLLI 427
Cdd:cd17325 162 LALVLALL 169
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
29-426 |
1.43e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.48 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 29 VCASFISIGFSYAFpkaVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMIL 108
Cdd:cd17333 1 LYISFFSNGLTDAL---LGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 109 ASFSSSVIeLYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFaMAGSPVFLSTLAPF--NQFLFNSYGWKGSFLI 186
Cdd:cd17333 78 IFATPSIY-LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNV-LHGFFGLGALIGPLiaTSLLTSELSWSWAYLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 187 LGAIFLhsCVAGCLMRpvgpspraAKSKSKVGSR-QDSSTKRLSKVSTAEKINRFLdfglfthrgfliyLSGNVVLFLGM 265
Cdd:cd17333 156 IGLIYL--LLAILILL--------TLFPELPSARnPQQSVGAFSASASRLLRNPSI-------------ILGALALFLYV 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 266 FAPIIFLA---PYAKD-KGVDDYNSAFLLSVMAFTDMFARPSVGLIANTslIRPRIQYLFSVAIMFTGICHLLcpLAHSY 341
Cdd:cd17333 213 GAETAFSSwvpSYLVEkKHVSDGLAGYLLSGFWVGITIGRLLGGPISRR--IKPHTLLVLSGSGALLGLLILL--LAPTL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 342 TALVVYVIFFGIGFGSISSLLFECLMDQVGASRfSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSS 421
Cdd:cd17333 289 VVGLVATALLGLFMAALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIF 367
|
....*
gi 2316768857 422 GIYLL 426
Cdd:cd17333 368 VLALL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
255-427 |
1.50e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 53.37 E-value: 1.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 255 LSGNVVLFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTslIRPRIQYLFSVAIMftGICHLL 334
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDR--FGRKRLLLIGLLIF--ALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 335 CPLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIAS 414
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAA 157
|
170
....*....|...
gi 2316768857 415 GIVVLSSGIYLLI 427
Cdd:cd17489 158 VLALLALLLVFLV 170
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
45-385 |
4.81e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 51.81 E-value: 4.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 45 AVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELyLTVGF 124
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL-IIFRI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 125 IGGLGLAFNLQPALTIIGKYFYRKRpLANGFAMAGSPVFLS-TLAP-FNQFLFNSYGWKGSFLILGAIflhsCVAGCLMR 202
Cdd:cd17503 93 LQGFGGGVLIPLAQTILLRIYPPEK-RGAAMGLVGLVILLApAIGPtLGGWLTDNLSWRWIFYINLPI----GILALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 203 PvgpspraakskskvgsrqdsstkrlskvstaekinrFLDFGLFTHRGFLIYLSGNVVLFLGMFAPIIFLAPYAKD-KGV 281
Cdd:cd17503 168 P------------------------------------LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNvLGY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 282 DDYNSAFLLSVMAFTDMFARPSVGLIANTslIRPRIQYLFSVAIMFTGICHLLCPLAHSYTALVVYVIF-FGIGFGSISS 360
Cdd:cd17503 212 SAFESGLVLAPGGLASAILSPLVGRLLDK--FGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFiRGLGMGLVFM 289
|
330 340
....*....|....*....|....*
gi 2316768857 361 LLFECLMDQVGASRFSSAVGLVTIV 385
Cdd:cd17503 290 PLNTLALNSLPPEQIGDATALFNTI 314
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
65-405 |
8.59e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.06 E-value: 8.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 65 AWISSIMLAVMYAGG---PISSVLVNNYGSR-----PVVIVGGLLCCTGMILA----SFSSSVIELYLTVGFIG-GLGLA 131
Cdd:COG2211 46 ALVGLILLVARLWDAitdPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLLftapDLSPTGKLIYALVTYLLlGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 132 FNLQPALTIIGKYF--YRKRPLANG----FAMAGSPVFLSTLAPFNQFLFNS--YGWKGSFLILGAIFLHSCVAGCLMRP 203
Cdd:COG2211 126 LVNIPYSALGAELTpdYEERTRLSSwrfaFAGLGGLLASVLPPPLVAAFGGDaaLGYRLTALIFAVLGLLAFLLTFFGTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 204 VGPSPRAAKSKSKVGSRQdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLGMFAPIIFLAPYAKDK-GVD 282
Cdd:COG2211 206 ERPVPEEEKVSLKESLKA-----------------------LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLS 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 283 DYNSAFLLSVMAFTDMFARPSVGLIANtslirpRI--QYLFSVAIMFTGICHLLCPLA--HSYTALVVYVIFFGIGFGSI 358
Cdd:COG2211 263 AALVGLLLALYFLAALLGAPLWPRLAK------RFgkKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAI 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2316768857 359 SSLLFECLMDQV-------GASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITG 405
Cdd:COG2211 337 LVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
25-190 |
4.27e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.89 E-value: 4.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 25 GWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:TIGR00895 15 QWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIELyLTVGFIGGLGLAFNLQPALTIIGKYF-YRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGS 183
Cdd:TIGR00895 95 FTLLCALATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYApKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSL 173
|
....*..
gi 2316768857 184 FLILGAI 190
Cdd:TIGR00895 174 FYVGGIA 180
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
26-427 |
1.45e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.18 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 26 WVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTG 105
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 106 MILASFSSSVIELYLtVGFIGGLGLAFNLQPALTIIGKYF-YRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSF 184
Cdd:cd17319 82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 185 LILGAIflhSCVAGCLMrpvgpspraakskskvgsrqdsstkrlskvstaekinrfldfgLFTHRGFLIYLSGNVVLFLG 264
Cdd:cd17319 161 IIEGLL---GLLLAVLW-------------------------------------------WFYLRQVWGLALGYFGINYA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 265 MFAPIIFLAPYAKD-KGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFsVAIMFTGICHLLCPLAHSYTA 343
Cdd:cd17319 195 LYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVII-IGLLLAAVGLLLAYLTTSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 344 LVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKY-LYIASGIVVLSSG 422
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAaFLFLAAVALLAAL 353
|
....*
gi 2316768857 423 IYLLI 427
Cdd:cd17319 354 LVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
27-203 |
4.40e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 4.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 27 VVVCASFISIGFSYAFPKAVTVFFND-----IKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSR--PVVIVGG 99
Cdd:COG2271 176 LLALLRFWLLALAYFLVYFALYGFLTwlptyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 100 LLCCTGMILASFSSSVIeLYLTVGFIGGLGLAFNLQPALTIIGKYFYRK-RPLANGFAMAGSPVFLSTLAPFNQFLFNSY 178
Cdd:COG2271 256 LLAALALLLLALLPSPA-LAIALLFLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
|
170 180
....*....|....*....|....*
gi 2316768857 179 GWKGSFLILGAIFLHSCVAGCLMRP 203
Cdd:COG2271 335 GYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
255-427 |
6.70e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 6.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 255 LSGNVVLFLGMFAPIIFLAPY-AKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANtsLIRPRIQYLFSVAIMftGICHL 333
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD--RFGRRRVLLIGLLLF--ALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 334 LCPLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGqYKYLYIA 413
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
|
170
....*....|....
gi 2316768857 414 SGIVVLSSGIYLLI 427
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
60-188 |
1.22e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.11 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 60 TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLTvGFIGGLGLAFNLQPALT 139
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL-RFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2316768857 140 IIGKYF-YRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSFLILG 188
Cdd:cd17365 111 LVSEYApARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
79-203 |
1.38e-04 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 41.87 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 79 GPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLTvGFIGGLGLAFNLQPALTIIGKYFYR-KRPLANGFAM 157
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIA-RFLQGFGAAFALVAGAALIADIYPPeERGVALGLMS 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2316768857 158 AGSPVFLSTLAPFNQFLFNSYGWKGSFLILGAIFLHSCVAGCLMRP 203
Cdd:TIGR00880 94 AGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
249-426 |
2.82e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 249 RGFLIYLSGNVVLFLGMFApIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANtsliRPRIQYLFSVAIMFT 328
Cdd:cd17370 200 KAFWLYLLAVALFALGNFS-FAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSD----RIGRKKLLILGYLSL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 329 GICHLLCPLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGqYK 408
Cdd:cd17370 275 ALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PS 353
|
170
....*....|....*...
gi 2316768857 409 YLYIASGIVVLSSGIYLL 426
Cdd:cd17370 354 AAFLFSAVLALIALLLLL 371
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
52-383 |
5.48e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.16 E-value: 5.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 52 DIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELylTVG-FIGGLGL 130
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL--IAArALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 131 AFnLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLA--PFNQFLFNSYGWKGSFLILGAIFLhscvagclmrpvgpsp 208
Cdd:cd17321 99 AA-IMPASLALIAATFPGERRGRALGLWGAVVGIGAALgpLLGGLLLELFGWRWIFLINVPIGL---------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 209 raakskskvgsrqdsstkrlskvstaekinrfldFGLFTHRGFLIYLSGNVVLFLGMFAPIIFLAPYAKD-KGVDDYNSA 287
Cdd:cd17321 162 ----------------------------------VALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 288 FLLSVMAFTDMFARPSVGLIANTslIRPRIQYLFSVAIMFTGICHL-LCPLAHSYTALVVYVIFFGIGFGSISSLLFECL 366
Cdd:cd17321 208 LALLPLALAMLVAAPLAGRLADR--FGPRLVLVAGLLLTAVGLLLLaLLGADSSVWLLLPGLVLLGLGLGLFATPLTNAA 285
|
330
....*....|....*..
gi 2316768857 367 MDQVGASRFSSAVGLVT 383
Cdd:cd17321 286 LSSVPKEKAGAASGILN 302
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
52-385 |
7.75e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.79 E-value: 7.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 52 DIKDIFKTTSSQIAWISSIMLAVMYAG----GPISSVlvnnYGSRPVVIVGGLLCCTGMILASFSSSvIELYLTVGFIGG 127
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGqllyGPLSDR----FGRRPVLLAGLLLFILASLLCALASS-IEQLLIARFLQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 128 LGLAFNLQPALTIIGKYfYRKRPLANGFAMAGSPVFLS-TLAP-FNQFLFNSYGWKGSFLILgAIFLHSCVAGCLMRPVG 205
Cdd:cd17320 99 LGAAAGSVVARAIVRDL-YSGAELAKIFSLLMMILAIApALAPlLGGLLLLFFGWRAIFVFL-ALLGLLLLLLVLLFLPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 206 PSPRAAKSKSKVGSRQDSstkrlskvstaekinrfldFGLFTHRGFLIYLSGNVVLFLGMF-----APIIFLAPYakdkG 280
Cdd:cd17320 177 TLPEEKRKPLLSSLLRAY-------------------KRVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIEQL----G 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 281 VDDYNSAFLLSVMAFTDMFArpsvGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLA-----HSYTALVVYVIFFGIGF 355
Cdd:cd17320 234 LSPAQFGLLFALNAIALILG----SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAallggLSLWPLVAPLFLIFFGF 309
|
330 340 350
....*....|....*....|....*....|..
gi 2316768857 356 GSISSLLFECLMDQVG--ASRFSSAVGLVTIV 385
Cdd:cd17320 310 GLIFPNATSLALEPFPhvAGTASALLGFLQFL 341
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
33-192 |
8.40e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 8.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 33 FISIGFSYAFPKAV--TVFFNDIKDIFKTTSSQIAWISSIM-LAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILA 109
Cdd:cd17330 179 LLLVYFLIALAFAGleSVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 110 SFSSSVIELYLTVGFIgGLGLAFNLQPALTIIGKYFYRK-RPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSFLILG 188
Cdd:cd17330 259 PFASSVPLLVLAAAIL-AFGTGIVFPALSALLSKSVPSKeQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAA 337
|
....
gi 2316768857 189 AIFL 192
Cdd:cd17330 338 GLLL 341
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
260-426 |
1.10e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.38 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 260 VLFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIanTSLIRPRIQYLFSVAIMftGICHLLCPLAH 339
Cdd:cd17324 10 AIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPL--SDRIERRRLLLVLLLLF--ILGNLLAALAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 340 SYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGqYKYLYIASGIVVL 419
Cdd:cd17324 86 SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLAL 164
|
....*..
gi 2316768857 420 SSGIYLL 426
Cdd:cd17324 165 LAALLLW 171
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-428 |
1.34e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.06 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 26 WVVVCASFI-SIGFSYAFPkAVTVFFNDIKDIfktTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCT 104
Cdd:cd17329 2 WVLLIGSFLnRLGFFMVWP-FMAIYLHQQLGL---SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 105 GMILASFSSSVIEL---YLTVGFIGGLglafnLQPAL-TIIG--------KYFYRKRPLANGFAMAGSPVFLSTLAPFNQ 172
Cdd:cd17329 78 GFALLGFAHSPWLFaiaLVLTGFGGGL-----FEPASeAMIAdvttpenrTRAFSLLYWAINLGVAIGPLLGGLLLLYSF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 173 FLFnsygwkgsFLILGAIFLHSC--VAGCLMRPVGPSPRAAKSKSKVGSRQdsstkrlskvstaekinrfldfgLFTHRG 250
Cdd:cd17329 153 RLL--------FLAAAVLFLLAAlvLLFLLPETRPKRRAAEKTEILRGYKI-----------------------VLRDRA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 251 FLIYLSGNVVLFLGMFAPIIFLAPYAKDKGVDDYNS-AFLLSVMAFTDMFARPSVGLIANtsliRPRIQYLFSVAIMFTG 329
Cdd:cd17329 202 FLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPVARLVE----RFRLRKILMIGILLFA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 330 ICHLLCPLAHSYTALVVYVIFFGIG---FGSISSLLFECLMDQVGASRFSSAVGLVTIVEccpVLFGPPLAGKLLDITGQ 406
Cdd:cd17329 278 IGFAVLAFANTLAVLILAMIVLTLGemlVFPAVQTLVAALAPPDKRGSYMGFYALAWGLG---RAIGPLVGGLLLDLLGP 354
|
410 420
....*....|....*....|..
gi 2316768857 407 YKYLYIASGIVVLSSGIYLLIC 428
Cdd:cd17329 355 GLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-192 |
1.77e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.64 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 27 VVVCASFISIGFSYAFpkAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGM 106
Cdd:cd17325 202 LALFLAIFVLAFAFGA--LEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 107 ILASFSSSVIELYLTVgFIGGLGLAFNLQPALTIIGKYFyrkRPLANGFAMAGSPVFLS---TLAPF-NQFLFNSYGWKG 182
Cdd:cd17325 280 LLLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIV---PPEGRGTAMGLFNTAFSlgmVLGPLlGGFLYDAFGFAT 355
|
170
....*....|
gi 2316768857 183 SFLILGAIFL 192
Cdd:cd17325 356 PFLAAAALLL 365
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
73-141 |
2.60e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.87 E-value: 2.60e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2316768857 73 AVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTII 141
Cdd:cd17504 228 LVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIV 296
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
257-431 |
2.85e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.85 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 257 GNVVLFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTslIRPRIqyLFSVAIMFTGICHLLCP 336
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADR--FGRRR--VLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 337 LAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGqYKYLYIASGI 416
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAFLILGL 172
|
170
....*....|....*
gi 2316768857 417 VVLSSGIYLLICNAI 431
Cdd:COG2271 173 PGLLLALLRFWLLAL 187
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
53-383 |
2.88e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.93 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 53 IKDIFKTTSSQIAWissiMLAVMYAGGPISSV----LVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLTVGFIGGL 128
Cdd:cd17341 25 IRDDLGLSTSQIGL----LVAIPVLAGALLRLpygfLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 129 GLAfNLQPALTIIGKYFYRKRP-----LANGFAMAGSPV---FLSTLAPFNQFLFNSYGWKGSFLILGAIFLHSCVAGCL 200
Cdd:cd17341 101 AGA-NFASGQPWASFWFPKEKIggaagGIAGAGNMGVAVsqlLAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 201 MR---PVGPSPRAAKSKSKVGSRQDSSTKRLSkvstaekinrfldfglfthrgfLIYlSGNVVLFLGMFApiiFLAPYAK 277
Cdd:cd17341 180 FGddlPTGKASALEFLKVQLAVLKNYRTWILS----------------------LLY-GVTFGSFVGFSN---VLPTYFK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 278 DK-GVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTALVVYV-IFFGIGF 355
Cdd:cd17341 234 TRfGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALfVALGLGA 313
|
330 340
....*....|....*....|....*...
gi 2316768857 356 GSISSLLFeclmdQVGASRFSSAVGLVT 383
Cdd:cd17341 314 GAGNGSVF-----RMVPFIFRRELGAVT 336
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
53-381 |
3.24e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.87 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 53 IKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLTVGfIGGLGLAF 132
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA-LQGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 133 nLQPALTIIGKYFYRKR-PLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSFLILGAIflhsCVAGCLMRPvgpspraa 211
Cdd:cd17504 101 -FPLAFALVREEFPPERvPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV----AVLLAALVP-------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 212 kskskvgsrqdsstkrlskvstaekinrFLDFGLFTHRGFLIYLSGNVVLFLGMFA-----PIIFLAPYAKDKGVDDYNS 286
Cdd:cd17504 168 ----------------------------LIDLRLLRRRNVLLANITALLAGFGMFMvfqllPQLLQLPTPTGFGLGITEA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 287 AFLLSVMAFTDMFARPSVGLIAntSLIRPRIQYLFSVAIMFTGIChLLCPLAHSYTALVVYVIFFGIGFGSISSLLFECL 366
Cdd:cd17504 220 GLLLLPGALVMLIAGPLAGRLI--ARVGPRRVLLIGLVISAVGLL-LLALLHSSLWALVVALLLIGIGLGLAFASLPNIV 296
|
330
....*....|....*
gi 2316768857 367 MDQVGASRFSSAVGL 381
Cdd:cd17504 297 VESVPPDRTGIATGM 311
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
60-191 |
4.90e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.53 E-value: 4.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 60 TSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLTVGFIG-GLGLAFNLQPAL 138
Cdd:cd06179 30 PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGiGAGTQGLGAAVA 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2316768857 139 T--IIGKYfyrkRPLANGFAMAGSPVFlSTLAPF--NQFLFNSY-GWKGSFLILGAIF 191
Cdd:cd06179 110 SelVPNKY----RGLVQGVVNLVASPG-SALGPLiaGALVEANAaGWRWIFYINAIFN 162
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
53-362 |
6.67e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 6.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 53 IKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSvIELYLTVGFIGGLGLAF 132
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN-YWLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 133 NLQPALTIIGKYFYRKRPLANGFAMAG-------SPVFLStlapfnqFLFNSYGWKGSFLILGAIFLHSCVAGCLMRPVG 205
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGgnlgfalGPLIAA-------ALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 206 PSPRAAKSKSKVgsrqdsstkrlskvstaekinrfLDFGLFTHRGFLIYLSGNVVL-FLGMFAPIIFLAPYAKDKGVDDY 284
Cdd:cd17478 174 KPEAKKAAAKSS-----------------------ARSTLKGVWRALLLLLIIVFLrSWVLSSLTTFLPFYLVQRGYSLV 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2316768857 285 NSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTgichLLCPLAHSYTALVVYVIFFGIGFGSISSLL 362
Cdd:cd17478 231 FAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFL----LLFLLTPGIWSYILLVLAGFLLFASFPVTV 304
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
61-419 |
6.84e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 6.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 61 SSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIeLYLTVGFIGGLGLAFNLQPALTI 140
Cdd:cd17477 30 TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-VWFLLRFVMGIGLAGLFVVSESW 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 141 IGKYF---YRKRPLA-----NGFAMAGSPVFLSTLAPFNQFLFnsygwkgsfLILGAIFLHSCVAGCLMRPVGPSPRAAk 212
Cdd:cd17477 109 LNALAtneNRGRVLGlystvLGLGFALGPLLLALVGTAGALPF---------LIAAVLLLLALVPLLLTRRAAPEIEEA- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 213 skskvgsrqdsstkrlskvstaekinrfldfglfTHRGFLIYLSGNVVLFLGMF-------APIIFLAPYAKDKGVDDYN 285
Cdd:cd17477 179 ----------------------------------ESISLRRLLRIAPLALLGAFvagflegAFYSLLPLYGLRLGLSVAQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 286 SAFLLSVMAFTDMFARPSVGLIANtSLIRPRIQYLFSVAIMFTGIchLLCPLAHSYTALVVYVIFFGIGFGSISSLLFEC 365
Cdd:cd17477 225 AALLLAAFVLGGLLLQWPLGWLAD-RFDRRRVLLGCALLGALAAL--LLPLVPGLPLALLVLLFLWGGAAGPLYTLALAL 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2316768857 366 LMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVL 419
Cdd:cd17477 302 AGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
46-425 |
9.58e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 38.37 E-value: 9.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 46 VTVFFNDIKDIFKTTSS-----QIAWISSIMLAvmyagGPISSVLVNNYgSRPVVIVGGLLCCTGM-ILASFSSSVIELY 119
Cdd:cd17328 18 IAGVLPDIQSDFLIDDSlagllQTVFIISYMVL-----SPIFGYLGDRY-NRKWILAVGILIWSAAtLLSSFAPNFWQLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 120 LTVGfIGGLGLAFNLQPALTIIGKYFYR-KRPLANGFAMAGSPVFlSTLAPFNQFLFNS--YGWKGSFLILGAIflhSCV 196
Cdd:cd17328 92 LFRA-LVGIGEASYSPIAPTIIADLFPKeKRTRALGVFYFAIPLG-SGLGYVVGGLVAQatGGWRWAFRVTGVL---GVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 197 AGCL-MRPVGPSPRAAKSKSKVGSRQDSSTKRLSKVSTAEKINRFLDFGlFTHRGFLIYLsgnvvlfLGMFAPIIFLAPY 275
Cdd:cd17328 167 LAILlLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLG-FTAVSFVTGA-------LAFWAPTFFLRAF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 276 AKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIAN-TSLIRPRIQYLFSVAIMF-TGICHLLCPLAHSYTALVVYV-IFFG 352
Cdd:cd17328 239 GVGDLSSADVGLIFGAITCIAGVLGVLLGGILADrLRRKTPRADPLVCAVGLLaAAPFLFLALVLALSNLLLAWVlLFLG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2316768857 353 IGFGSI-SSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKY-------------LYIASGIVV 418
Cdd:cd17328 319 EFLLSLnWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNKdsplaeaaslqyaLLLCSFVLV 398
|
....*..
gi 2316768857 419 LSSGIYL 425
Cdd:cd17328 399 LGGFFFL 405
|
|
| |
