NCBI Conserved Domain Search

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

98-178

4.98e-45

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.

Pssm-ID: 349342 [Multi-domain] Cd Length: 81 Bit Score: 156.62 E-value: 4.98e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070   98 IFFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCVSEKRRKD 177
Cdd:cd17710    1 LFSGVVVCPSQISAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALKHEGIKIVTPDWVTDCIKAKTLLD 80


                 .
gi 81885070  178 E 178
Cdd:cd17710   81 E 81

BRCT_PAXIP1_rpt4

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

696-768

9.02e-41

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.

Pssm-ID: 349362 [Multi-domain] Cd Length: 73 Bit Score: 144.31 E-value: 9.02e-41

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81885070  696 HIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLGDILLGNFE 768
Cdd:cd17730    1 QVISVTGFDGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDILLGGRL 73

BRCT_PAXIP1_rpt3

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

595-676

1.66e-39

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.

Pssm-ID: 349343 Cd Length: 81 Bit Score: 140.86 E-value: 1.66e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  595 GCVFAIADYPEQMSDkQLLATWKRIIQAHGGTVDPTFTSRCTHLLCASQVSSMYTQALRERKRCVTAHWLNTVLKKKKLM 674
Cdd:cd17711    1 GCVFFIADYPEQMGD-QEIATWKKVIEEHGGEVVDEYSPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKLL 79


                 ..
gi 81885070  675 PP 676
Cdd:cd17711   80 PP 81

BRCT_PAXIP1_rpt5

cd17712

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

853-927

1.42e-37

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.

Pssm-ID: 349344 Cd Length: 75 Bit Score: 135.06 E-value: 1.42e-37

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  853 TPLVLFTGFEPVQVQQYIKKLYILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQTFI 927
Cdd:cd17712    1 TPRVLFTGFDPVQVRKLTKKVTILGGEVVESPQECTHLVAPKVSRTVKFLTAISVCKHIVTPEWLEESFKQGKFL 75

BRCT_PAXIP1_rpt1

cd17714

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; ...

13-87

1.71e-35

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the first BRCT domain.

Pssm-ID: 349346 Cd Length: 76 Bit Score: 129.36 E-value: 1.71e-35

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070   13 FREVKYYAVGDIDPQVIQLLKAGKAKEVSYNA-LASHIISEDGDNPEVGEAREVFDLPVVKPSWVTLSVQCGALLP 87
Cdd:cd17714    1 FKDVKYFVVGNLDEKVEQLLKNGGAKEVSYLSdMATHVIVDDNDNPEVGEARDLFELPVVTSSWVILSIKAGKLLP 76

Name

Accession

Description

Interval

E-value

BRCT_PAXIP1_rpt6

cd18440

sixth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

959-1049

3.99e-47

Pssm-ID: 349393 Cd Length: 90 Bit Score: 162.77 E-value: 3.99e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  959 LFKTKYFYITPGICPSLATMKAIVECAGGKVLAKQPSFRKLMEhKQNKSLSEIILISCENDLHLCREYFARGIDVHNAEF 1038
Cdd:cd18440    1 LFKGKYFYITPGVKPSPSVLKEIIESAGGKVEKKRPSLKKIME-KNNQGPPSYIIITCENDLHLCRDLFRKNIDVYNAEF 79

                         90
                 ....*....|.
gi 81885070 1039 VLTGVLTQTLD 1049
Cdd:cd18440   80 ILTGVLRQKLD 90

BRCT_PAXIP1_rpt2

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

98-178

4.98e-45

Pssm-ID: 349342 [Multi-domain] Cd Length: 81 Bit Score: 156.62 E-value: 4.98e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070   98 IFFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCVSEKRRKD 177
Cdd:cd17710    1 LFSGVVVCPSQISAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALKHEGIKIVTPDWVTDCIKAKTLLD 80


                 .
gi 81885070  178 E 178
Cdd:cd17710   81 E 81

BRCT_PAXIP1_rpt4

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

696-768

9.02e-41

Pssm-ID: 349362 [Multi-domain] Cd Length: 73 Bit Score: 144.31 E-value: 9.02e-41

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81885070  696 HIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLGDILLGNFE 768
Cdd:cd17730    1 QVISVTGFDGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDILLGGRL 73

BRCT_PAXIP1_rpt3

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

595-676

1.66e-39

Pssm-ID: 349343 Cd Length: 81 Bit Score: 140.86 E-value: 1.66e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  595 GCVFAIADYPEQMSDkQLLATWKRIIQAHGGTVDPTFTSRCTHLLCASQVSSMYTQALRERKRCVTAHWLNTVLKKKKLM 674
Cdd:cd17711    1 GCVFFIADYPEQMGD-QEIATWKKVIEEHGGEVVDEYSPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKLL 79


                 ..
gi 81885070  675 PP 676
Cdd:cd17711   80 PP 81

BRCT_PAXIP1_rpt5

cd17712

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

853-927

1.42e-37

Pssm-ID: 349344 Cd Length: 75 Bit Score: 135.06 E-value: 1.42e-37

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  853 TPLVLFTGFEPVQVQQYIKKLYILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQTFI 927
Cdd:cd17712    1 TPRVLFTGFDPVQVRKLTKKVTILGGEVVESPQECTHLVAPKVSRTVKFLTAISVCKHIVTPEWLEESFKQGKFL 75

BRCT_PAXIP1_rpt1

cd17714

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; ...

13-87

1.71e-35

Pssm-ID: 349346 Cd Length: 76 Bit Score: 129.36 E-value: 1.71e-35

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070   13 FREVKYYAVGDIDPQVIQLLKAGKAKEVSYNA-LASHIISEDGDNPEVGEAREVFDLPVVKPSWVTLSVQCGALLP 87
Cdd:cd17714    1 FKDVKYFVVGNLDEKVEQLLKNGGAKEVSYLSdMATHVIVDDNDNPEVGEARDLFELPVVTSSWVILSIKAGKLLP 76

RTT107_BRCT_5

pfam16770

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of ...

846-934

2.25e-24

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of regulator of Ty1 transposition protein 107 (RTT107). It is involved in binding phosphorylated histone H2A.

Pssm-ID: 465266 Cd Length: 91 Bit Score: 97.98 E-value: 2.25e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070    846 KKLTPELTPLVLFTGFE--PVQVQQYIKKLYILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKR 923
Cdd:pfam16770    1 KKSLPPYDIRAVLTGCErwIDKEDLDKKKLRLLGIKIVQDPSKCNHLIAPKILRTEKFLCALAFAPYILSPDFITDCLKE 80

                           90
                   ....*....|.
gi 81885070    924 QTFIDEQNYIL 934
Cdd:pfam16770   81 GKLPDEEDYLL 91

PTCB-BRCT

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...

697-758

2.38e-24

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.

Pssm-ID: 463687 [Multi-domain] Cd Length: 63 Bit Score: 96.89 E-value: 2.38e-24

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885070    697 IISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQW 758
Cdd:pfam12738    2 VICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63

PTCB-BRCT

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...

102-165

5.61e-20

Pssm-ID: 463687 [Multi-domain] Cd Length: 63 Bit Score: 84.56 E-value: 5.61e-20

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81885070    102 LTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTsIKIVTPDW 165
Cdd:pfam12738    1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWG-IPVVSPLW 63

BRCT

breast cancer carboxy-terminal domain;

98-170

3.68e-11

breast cancer carboxy-terminal domain;

Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 60.08 E-value: 3.68e-11

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070      98 IFFGLTACLSQV-SSEDRSALWALVTFHGGSCQLNLNKK-CTHLIVPEPKGEKYERAV-KRTSIKIVTPDWVLDCV 170
Cdd:smart00292    3 LFKGKTFYITGSfDKEERDELKELIEALGGKVTSSLSSKtTTHVIVGSPEGGKLELLKaIALGIPIVKEEWLLDCL 78

BRCT

breast cancer carboxy-terminal domain;

691-763

4.75e-11

breast cancer carboxy-terminal domain;

Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 59.70 E-value: 4.75e-11

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81885070     691 KPCSQHIISVTG-FVDNDRDDLKLMAYLAGAKYTGYLCR-SNTVLICKEPSG--LKYEKAKEWRIPCVNAQWLGDIL 763
Cdd:smart00292    2 KLFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSSkTTTHVIVGSPEGgkLELLKAIALGIPIVKEEWLLDCL 78

BRCT

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...

588-664

8.72e-09

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.

Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 53.07 E-value: 8.72e-09

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81885070    588 PEESFLLGCVFAIadYPEQMSDKQLLatwKRIIQAHGGTVDPTFTSRCTHLLCASqVSSMYTQALRERKRCVTAHWL 664
Cdd:pfam00533    1 PKEKLFSGKTFVI--TGLDGLERDEL---KELIEKLGGKVTDSLSKKTTHVIVEA-RTKKYLKAKELGIPIVTEEWL 71

BRCT

breast cancer carboxy-terminal domain;

856-921

4.80e-08

breast cancer carboxy-terminal domain;

Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 51.22 E-value: 4.80e-08

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070     856 VLFTG-FEPVQVQQYIKKLYILGGEVAE--CTKKCTHLIASKV-TRTVKFLTAISVVKHIVTPDWLEECF 921
Cdd:smart00292    9 FYITGsFDKEERDELKELIEALGGKVTSslSSKTTTHVIVGSPeGGKLELLKAIALGIPIVKEEWLLDCL 78

BRCT

breast cancer carboxy-terminal domain;

590-664

1.66e-06

breast cancer carboxy-terminal domain;

Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 46.60 E-value: 1.66e-06

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81885070     590 ESFLLGCVFAIADYPEQMSDKQLlatwKRIIQAHGGTVDPTFTS-RCTHLLCASQVSSMYT--QALRERKRCVTAHWL 664
Cdd:smart00292    1 PKLFKGKTFYITGSFDKEERDEL----KELIEALGGKVTSSLSSkTTTHVIVGSPEGGKLEllKAIALGIPIVKEEWL 74

BRCT

breast cancer carboxy-terminal domain;

957-1040

7.86e-05

breast cancer carboxy-terminal domain;

Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 41.98 E-value: 7.86e-05

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070     957 SPLFKTKYFYITPGIC-PSLATMKAIVECAGGKVLAKQPSfrklmehkqnKSLSEIILISCENDLHLCREYFARGIDVHN 1035
Cdd:smart00292    1 PKLFKGKTFYITGSFDkEERDELKELIEALGGKVTSSLSS----------KTTTHVIVGSPEGGKLELLKAIALGIPIVK 70


                    ....*
gi 81885070    1036 AEFVL 1040
Cdd:smart00292   71 EEWLL 75

Name

Accession

Description

Interval

E-value

BRCT_PAXIP1_rpt6

cd18440

sixth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

959-1049

3.99e-47

Pssm-ID: 349393 Cd Length: 90 Bit Score: 162.77 E-value: 3.99e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  959 LFKTKYFYITPGICPSLATMKAIVECAGGKVLAKQPSFRKLMEhKQNKSLSEIILISCENDLHLCREYFARGIDVHNAEF 1038
Cdd:cd18440    1 LFKGKYFYITPGVKPSPSVLKEIIESAGGKVEKKRPSLKKIME-KNNQGPPSYIIITCENDLHLCRDLFRKNIDVYNAEF 79

                         90
                 ....*....|.
gi 81885070 1039 VLTGVLTQTLD 1049
Cdd:cd18440   80 ILTGVLRQKLD 90

BRCT_PAXIP1_rpt2

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

98-178

4.98e-45

Pssm-ID: 349342 [Multi-domain] Cd Length: 81 Bit Score: 156.62 E-value: 4.98e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070   98 IFFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCVSEKRRKD 177
Cdd:cd17710    1 LFSGVVVCPSQISAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALKHEGIKIVTPDWVTDCIKAKTLLD 80


                 .
gi 81885070  178 E 178
Cdd:cd17710   81 E 81

BRCT_PAXIP1_rpt4

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

696-768

9.02e-41

Pssm-ID: 349362 [Multi-domain] Cd Length: 73 Bit Score: 144.31 E-value: 9.02e-41

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81885070  696 HIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLGDILLGNFE 768
Cdd:cd17730    1 QVISVTGFDGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDILLGGRL 73

BRCT_PAXIP1_rpt3

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

595-676

1.66e-39

Pssm-ID: 349343 Cd Length: 81 Bit Score: 140.86 E-value: 1.66e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  595 GCVFAIADYPEQMSDkQLLATWKRIIQAHGGTVDPTFTSRCTHLLCASQVSSMYTQALRERKRCVTAHWLNTVLKKKKLM 674
Cdd:cd17711    1 GCVFFIADYPEQMGD-QEIATWKKVIEEHGGEVVDEYSPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKLL 79


                 ..
gi 81885070  675 PP 676
Cdd:cd17711   80 PP 81

BRCT_PAXIP1_rpt5

cd17712

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

853-927

1.42e-37

Pssm-ID: 349344 Cd Length: 75 Bit Score: 135.06 E-value: 1.42e-37

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  853 TPLVLFTGFEPVQVQQYIKKLYILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQTFI 927
Cdd:cd17712    1 TPRVLFTGFDPVQVRKLTKKVTILGGEVVESPQECTHLVAPKVSRTVKFLTAISVCKHIVTPEWLEESFKQGKFL 75

BRCT_PAXIP1_rpt1

cd17714

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; ...

13-87

1.71e-35

Pssm-ID: 349346 Cd Length: 76 Bit Score: 129.36 E-value: 1.71e-35

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070   13 FREVKYYAVGDIDPQVIQLLKAGKAKEVSYNA-LASHIISEDGDNPEVGEAREVFDLPVVKPSWVTLSVQCGALLP 87
Cdd:cd17714    1 FKDVKYFVVGNLDEKVEQLLKNGGAKEVSYLSdMATHVIVDDNDNPEVGEARDLFELPVVTSSWVILSIKAGKLLP 76

BRCT_PAXIP1_rpt6_like

cd18432

sixth BRCT domain of PAX-interacting protein 1 (PAXIP1), second BRCT domain of mediator of DNA ...

959-1049

2.08e-29

sixth BRCT domain of PAX-interacting protein 1 (PAXIP1), second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the sixth BRCT domain of PAXIP1 and the second BRCT domain of MDC1.

Pssm-ID: 349385 [Multi-domain] Cd Length: 85 Bit Score: 112.29 E-value: 2.08e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  959 LFKTKYFYITPGICPSLATMKAIVECAGGKVLAKQPSFRklmehkQNKSLSEIILISCENDLHLCREYFARGIDVHNAEF 1038
Cdd:cd18432    1 LFEGYTFYVTPNVKPPPEELKEIIEAAGGKVLKKLPTKR------IEDDDPDTIVISCEEDRKLWKPLKKKGIPIYSVEF 74

                         90
                 ....*....|.
gi 81885070 1039 VLTGVLTQTLD 1049
Cdd:cd18432   75 ILTGILRQKLD 85

RTT107_BRCT_5

pfam16770

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of ...

846-934

2.25e-24

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of regulator of Ty1 transposition protein 107 (RTT107). It is involved in binding phosphorylated histone H2A.

Pssm-ID: 465266 Cd Length: 91 Bit Score: 97.98 E-value: 2.25e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070    846 KKLTPELTPLVLFTGFE--PVQVQQYIKKLYILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKR 923
Cdd:pfam16770    1 KKSLPPYDIRAVLTGCErwIDKEDLDKKKLRLLGIKIVQDPSKCNHLIAPKILRTEKFLCALAFAPYILSPDFITDCLKE 80

                           90
                   ....*....|.
gi 81885070    924 QTFIDEQNYIL 934
Cdd:pfam16770   81 GKLPDEEDYLL 91

PTCB-BRCT

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...

697-758

2.38e-24

Pssm-ID: 463687 [Multi-domain] Cd Length: 63 Bit Score: 96.89 E-value: 2.38e-24

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885070    697 IISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQW 758
Cdd:pfam12738    2 VICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63

BRCT_TopBP1_rpt2_like

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

98-170

9.78e-23

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.

Pssm-ID: 349363 [Multi-domain] Cd Length: 77 Bit Score: 92.99 E-value: 9.78e-23

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81885070   98 IFFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCV 170
Cdd:cd17731    2 PFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNSIHIVTPEWLYDSI 74

PTCB-BRCT

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...

102-165

5.61e-20

Pssm-ID: 463687 [Multi-domain] Cd Length: 63 Bit Score: 84.56 E-value: 5.61e-20

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81885070    102 LTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTsIKIVTPDW 165
Cdd:pfam12738    1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWG-IPVVSPLW 63

BRCT

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...

102-169

3.92e-19

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.

Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 82.41 E-value: 3.92e-19

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81885070  102 LTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDC 169
Cdd:cd00027    1 LVICFSGLDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWLLDC 68

BRCT_MDC1_rpt1

cd17744

first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...

854-927

6.12e-19

first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the first BRCT domain.

Pssm-ID: 349375 [Multi-domain] Cd Length: 72 Bit Score: 81.90 E-value: 6.12e-19

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81885070  854 PLVLFTGFEPVQvqQYIKKLYILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQTFI 927
Cdd:cd17744    1 PRVLFTGVSDKE--EGEKIIKKLGGSVVDSVEDCTHLVTDKVRRTVKFLCALARGIPIVSPDWLEASIKANKFL 72

BRCT_BRC1_like_rpt5

cd17743

fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...

856-924

7.89e-18

fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contain six BRCT domains. This family corresponds to the fifth one.

Pssm-ID: 349374 Cd Length: 70 Bit Score: 78.44 E-value: 7.89e-18

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81885070  856 VLFTGFEPVQVQQyIKKLYILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQ 924
Cdd:cd17743    3 LLFTGYKLWTEKE-IKKLKKLGISIVEDPDECTHLVAPKIVRTEKFLCALAYAPVIVTTDWLEACLKAG 70

BRCT

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...

856-920

9.09e-15

Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 69.70 E-value: 9.09e-15

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070  856 VLFTGFEPVQVQQYIKKLYILGGEVAEC-TKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEEC 920
Cdd:cd00027    3 ICFSGLDDEEREELKKLIEALGGKVSESlSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWLLDC 68

BRCT_MDC1_rpt2

cd18441

second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...

966-1049

1.85e-14

second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the second BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.

Pssm-ID: 349394 Cd Length: 81 Bit Score: 69.33 E-value: 1.85e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  966 YITPGICPSLATMKAIVECAGGKVLAKQPSfrklmEHKQNkslseIILISCENDLHLCREYFARGIDVHNAEFVLTGVLT 1045
Cdd:cd18441    8 HVTPGVKPEPPQMKDIITCAGGTFLPSMPK-----TYKPQ-----TVVISCPEDFPHCSPALKAGLPVVSAEFLLTGILR 77


                 ....
gi 81885070 1046 QTLD 1049
Cdd:cd18441   78 QEAD 81

BRCT_BRC1_like_rpt2

cd18436

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...

99-170

4.34e-14

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.

Pssm-ID: 349389 [Multi-domain] Cd Length: 75 Bit Score: 68.03 E-value: 4.34e-14

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81885070   99 FFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKR--TSIKIVTPDWVLDCV 170
Cdd:cd18436    1 FSGVVITCSDLPSGDKEAIYGGVLALGGQYSDELTRDVTHLIALSPDGDKYKTALKRpeLNIKIVLPHWFDDCF 74

BRCT

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...

691-763

7.82e-14

Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 67.32 E-value: 7.82e-14

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81885070    691 KPCSQHIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSgLKYEKAKEWRIPCVNAQWLGDIL 763
Cdd:pfam00533    4 KLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEART-KKYLKAKELGIPIVTEEWLLDCI 75

BRCT

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...

697-759

9.45e-14

Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 67.00 E-value: 9.45e-14

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81885070  697 IISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKY-EKAKEWRIPCVNAQWL 759
Cdd:cd00027    2 VICFSGLDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYyLAALAWGIPIVSPEWL 65

BRCT_TopBP1_rpt2_like

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

697-761

1.10e-13

Pssm-ID: 349363 [Multi-domain] Cd Length: 77 Bit Score: 67.18 E-value: 1.10e-13

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070  697 IISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWR-IPCVNAQWLGD 761
Cdd:cd17731    7 VICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYD 72

BRCT_BRC1_like_rpt4

cd18438

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...

697-761

1.18e-13

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.

Pssm-ID: 349391 [Multi-domain] Cd Length: 68 Bit Score: 66.64 E-value: 1.18e-13

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  697 IISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLGD 761
Cdd:cd18438    2 KITITNYTGAARQYLEKLILALGATYTKNLKPDNTHLITASPEGEKYEAAKEWNIPIVNHLWLYD 66

BRCT_TopBP1_rpt5

cd18434

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

697-759

1.76e-13

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain.

Pssm-ID: 349387 Cd Length: 89 Bit Score: 66.94 E-value: 1.76e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885070  697 IISVTGFVDNDRDDLKLMAYLAGAKYTGYLCR---------SNTVLICKEPSGLKYEKAKEWRIPCVNAQWL 759
Cdd:cd18434    6 VISVSQFTGTERDCLTHLAELLGAKVQDYFVRkanpskgllASTHLVLKEPEGSKYEAAKKWNLPAVTKSWL 77

BRCT_TopBP1_rpt7

cd17738

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...

853-922

4.52e-13

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.

Pssm-ID: 349370 [Multi-domain] Cd Length: 75 Bit Score: 65.28 E-value: 4.52e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81885070  853 TPLVLFTGFEPVQVQQYIKKLYILGGEVAECTK---KCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFK 922
Cdd:cd17738    1 KPVFLLSGFSEDEKKELISIIEKLGGKVLDSDEfdpKCTHLICGKPSRSEKFLAACAAGKWILHPSYIEASAK 73

BRCT_CTDP1

cd17729

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...

114-178

2.85e-12

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.

Pssm-ID: 349361 [Multi-domain] Cd Length: 97 Bit Score: 63.71 E-value: 2.85e-12

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  114 RSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCVSEKRRKDE 178
Cdd:cd17729   33 RSRLWKLAESLGAKVVTDLSPRTTHLVAAKLGTEKVKQALKMPGIHVVHPDWLWACAERWERVDE 97

BRCT_BRC1_like_rpt6

cd18439

sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) ...

940-1049

4.89e-12

sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the sixth repeat.

Pssm-ID: 349392 Cd Length: 116 Bit Score: 63.86 E-value: 4.89e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  940 EVLFSFSLEESLKRAHVS--PLFKTKYFYITPGICPSLATMKAIVECAGGKVLAKQPSFRKLmeHKQNKSLSEIILISCE 1017
Cdd:cd18439    1 EKKYGCTLAESLARAKANkgKLLKGYTVYLTPKVKGGVETFKSIVEANGGICNLLRAAKGKL--GDGIAEKGPVVLISTT 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 81885070 1018 NDLHLC---REYFARG---IDVHNAEFVLTGVLTQTLD 1049
Cdd:cd18439   79 KEKKLWpkfLKNAREGgkePRVYSTDWLLDVVLRQELV 116

BRCT

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...

98-170

1.23e-11

Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 61.16 E-value: 1.23e-11

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81885070     98 IFFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVpEPKGEKYERAVKRtSIKIVTPDWVLDCV 170
Cdd:pfam00533    5 LFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIV-EARTKKYLKAKEL-GIPIVTEEWLLDCI 75

BRCT

breast cancer carboxy-terminal domain;

98-170

3.68e-11

breast cancer carboxy-terminal domain;

Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 60.08 E-value: 3.68e-11

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070      98 IFFGLTACLSQV-SSEDRSALWALVTFHGGSCQLNLNKK-CTHLIVPEPKGEKYERAV-KRTSIKIVTPDWVLDCV 170
Cdd:smart00292    3 LFKGKTFYITGSfDKEERDELKELIEALGGKVTSSLSSKtTTHVIVGSPEGGKLELLKaIALGIPIVKEEWLLDCL 78

BRCT

breast cancer carboxy-terminal domain;

691-763

4.75e-11

breast cancer carboxy-terminal domain;

Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 59.70 E-value: 4.75e-11

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81885070     691 KPCSQHIISVTG-FVDNDRDDLKLMAYLAGAKYTGYLCR-SNTVLICKEPSG--LKYEKAKEWRIPCVNAQWLGDIL 763
Cdd:smart00292    2 KLFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSSkTTTHVIVGSPEGgkLELLKAIALGIPIVKEEWLLDCL 78

BRCT_TopBP1_rpt5

cd18434

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

105-178

3.79e-10

Pssm-ID: 349387 Cd Length: 89 Bit Score: 57.31 E-value: 3.79e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  105 CLSQVSSEDRSALWALVTFHGGSCQ------LNLNKK---CTHLIVPEPKGEKYERAVKrTSIKIVTPDWVLDCVSEKRR 175
Cdd:cd18434    8 SVSQFTGTERDCLTHLAELLGAKVQdyfvrkANPSKGllaSTHLVLKEPEGSKYEAAKK-WNLPAVTKSWLFECARTGKK 86


                 ...
gi 81885070  176 KDE 178
Cdd:cd18434   87 VPE 89

BRCT

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...

856-921

4.17e-10

Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 56.92 E-value: 4.17e-10

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81885070    856 VLFTGFEPVQVQQYIKKLYILGGEVAEC-TKKCTHLIAskVTRTVKFLTAISVVKHIVTPDWLEECF 921
Cdd:pfam00533   11 FVITGLDGLERDELKELIEKLGGKVTDSlSKKTTHVIV--EARTKKYLKAKELGIPIVTEEWLLDCI 75

BRCT_PAXIP1_rpt2

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

595-676

7.87e-10

Pssm-ID: 349342 [Multi-domain] Cd Length: 81 Bit Score: 56.09 E-value: 7.87e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  595 GCVFAIAdypeQMSDKQLLATWkRIIQAHGGTVDPTFTSRCTHLLCASQVSSMYTQALRERK-RCVTAHWLNTVLKKKKL 673
Cdd:cd17710    4 GVVVCPS----QISAEDRLKLW-AMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALKHEGiKIVTPDWVTDCIKAKTL 78


                 ...
gi 81885070  674 MPP 676
Cdd:cd17710   79 LDE 81

BRCT_Rev1

cd17719

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...

98-181

1.01e-09

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.

Pssm-ID: 349351 [Multi-domain] Cd Length: 87 Bit Score: 56.04 E-value: 1.01e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070   98 IFFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNK-KCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCVSEKRRK 176
Cdd:cd17719    1 IFKGVVIYVNGYTDPSADELKRLILLHGGQYEHYYSRsRVTHIIATNLPGSKIKKLKKARNYKVVRPEWIVDSIKAGRLL 80


                 ....*
gi 81885070  177 DEAFY 181
Cdd:cd17719   81 PEAPY 85

BRCT_Rad4_rpt4

cd17723

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...

698-763

2.28e-09

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.

Pssm-ID: 349355 [Multi-domain] Cd Length: 74 Bit Score: 54.57 E-value: 2.28e-09

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81885070  698 ISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICK--EPSGLKYEKAKEWRIPCVNAQWLGDIL 763
Cdd:cd17723    4 ISLTGFSGVDLLHISKLIKLLGAKYHESLTKDRSLLIVNstEKKSDKINFAKKWGIPVVSVEWLWDCL 71

BRCT_PARP4_like

cd17726

BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also ...

96-177

4.65e-09

BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also termed 193 kDa vault protein, or ADP-ribosyltransferase diphtheria toxin-like 4 (ARTD4), or PARP-related/IalphaI-related H5/proline-rich (PH5P), or vault poly(ADP-ribose) polymerase (VPARP), shows poly(ADP-ribosyl)ation activity that catalyzes the formation of ADP-ribose polymers in response to DNA damage. PARP-4 is a component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group.

Pssm-ID: 349358 [Multi-domain] Cd Length: 85 Bit Score: 54.22 E-value: 4.65e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070   96 CQIFFGLTACLSQvssEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGE---KYERAVKrTSIKIVTPDWVLDCVSE 172
Cdd:cd17726    5 CQIVLDLKTLPGF---KEKKKLKKKITENGGIISYIINKKCTHVVVNNAKALssyKCRMAQK-YGIPVVSLDYIWKCVEA 80


                 ....*
gi 81885070  173 KRRKD 177
Cdd:cd17726   81 GKLLD 85

BRCT_nibrin

cd17741

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...

853-919

5.76e-09

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.

Pssm-ID: 349372 [Multi-domain] Cd Length: 74 Bit Score: 53.76 E-value: 5.76e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885070  853 TPLVL----FTGFEPVQVQQYIKKLyilGGEVA-ECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEE 919
Cdd:cd17741    1 EPLVVcsscLDSEEKKKLKQIIAKL---GGKVVnEWTEECTHLVMSKIKVTVKVICALISGKPIVTPEYLDA 69

BRCT_Rad4_rpt2

cd17746

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...

99-181

7.26e-09

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.

Pssm-ID: 349377 [Multi-domain] Cd Length: 91 Bit Score: 53.78 E-value: 7.26e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070   99 FFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKrTSIKIVTPDWVLDCVSEKRRKDE 178
Cdd:cd17746    7 LFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALK-WKINVVCVEWLWQSIQRNAVLEP 85


                 ...
gi 81885070  179 AFY 181
Cdd:cd17746   86 QYF 88

BRCT_TopBP1_rpt2_like

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

593-671

8.49e-09

Pssm-ID: 349363 [Multi-domain] Cd Length: 77 Bit Score: 53.31 E-value: 8.49e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  593 LLGCVFAIADYPEQmsDKQLLatwKRIIQAHGGTVDPTFTSRCTHLLCASQVSSMYTQALRERK-RCVTAHWLNTVLKKK 671
Cdd:cd17731    3 FKGLVICVTGFDSE--ERKEI---QQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNSiHIVTPEWLYDSIEAG 77

BRCT

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...

588-664

8.72e-09

Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 53.07 E-value: 8.72e-09

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81885070    588 PEESFLLGCVFAIadYPEQMSDKQLLatwKRIIQAHGGTVDPTFTSRCTHLLCASqVSSMYTQALRERKRCVTAHWL 664
Cdd:pfam00533    1 PKEKLFSGKTFVI--TGLDGLERDEL---KELIEKLGGKVTDSLSKKTTHVIVEA-RTKKYLKAKELGIPIVTEEWL 71

BRCT_XRCC1_rpt1

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...

101-181

3.96e-08

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.

Pssm-ID: 349357 [Multi-domain] Cd Length: 80 Bit Score: 51.51 E-value: 3.96e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  101 GLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYeRAVKRTSIKIVTPDWVLDCVSEKRRKDEAF 180
Cdd:cd17725    1 GVVFVLSGFQNPFRGELRDKALEMGAKYRPDWTADCTHLICAFANTPKY-KQVKGAGGIIVSKEWILDCYKKKKRLPWKR 79


                 .
gi 81885070  181 Y 181
Cdd:cd17725   80 Y 80

BRCT

breast cancer carboxy-terminal domain;

856-921

4.80e-08

breast cancer carboxy-terminal domain;

Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 51.22 E-value: 4.80e-08

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070     856 VLFTG-FEPVQVQQYIKKLYILGGEVAE--CTKKCTHLIASKV-TRTVKFLTAISVVKHIVTPDWLEECF 921
Cdd:smart00292    9 FYITGsFDKEERDELKELIEALGGKVTSslSSKTTTHVIVGSPeGGKLELLKAIALGIPIVKEEWLLDCL 78

BRCT_PAXIP1_rpt4

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

105-170

5.13e-08

Pssm-ID: 349362 [Multi-domain] Cd Length: 73 Bit Score: 50.70 E-value: 5.13e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070  105 CLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAvKRTSIKIVTPDWVLDCV 170
Cdd:cd17730    4 SVTGFDGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKA-KEWRIPVVNAQWLEDIL 68

BRCT

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...

609-664

6.49e-08

Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 50.44 E-value: 6.49e-08

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 81885070  609 DKQLLATWKRIIQAHGGTVDPTFTSRCTHLLCASQVSSMYT-QALRERKRCVTAHWL 664
Cdd:cd00027    9 DDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYYlAALAWGIPIVSPEWL 65

BRCT_CHS5_like

cd17742

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...

705-759

9.82e-08

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.

Pssm-ID: 349373 [Multi-domain] Cd Length: 77 Bit Score: 50.02 E-value: 9.82e-08

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  705 DNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWL 759
Cdd:cd17742   13 PESVDELEQCLERIGAKPTDRVAIDTTHFVCTVPSGPEYEKAKEMNIPIVRPEWL 67

BRCT_Rad4_rpt1

cd17740

first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...

101-169

1.01e-07

first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples the S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the first one.

Pssm-ID: 349371 Cd Length: 82 Bit Score: 50.17 E-value: 1.01e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  101 GLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVK-RTSIKIVTPDWVLDC 169
Cdd:cd17740    5 GIVLCCTSIPAEQRTEIATKASKMGAAYTADLTSDVTHLVAGQVNTTKYKFAARsRPDIKVMTVEWVEHL 74

BRCT_XRCC1_rpt1

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...

595-675

1.51e-07

Pssm-ID: 349357 [Multi-domain] Cd Length: 80 Bit Score: 49.58 E-value: 1.51e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  595 GCVFAIADY--PE--QMSDKQLlatwkriiqAHGGTVDPTFTSRCTHLLCASQVSSMYTQALRERKRCVTAHWLNTVLKK 670
Cdd:cd17725    1 GVVFVLSGFqnPFrgELRDKAL---------EMGAKYRPDWTADCTHLICAFANTPKYKQVKGAGGIIVSKEWILDCYKK 71


                 ....*
gi 81885070  671 KKLMP 675
Cdd:cd17725   72 KKRLP 76

BRCT_TopBP1_rpt2_like

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

859-923

1.55e-07

Pssm-ID: 349363 [Multi-domain] Cd Length: 77 Bit Score: 49.46 E-value: 1.55e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81885070  859 TGFEPV---QVQQYIKKLyilGGEV-AECTKKCTHLIASKVTrTVKFLTAI--SVVkHIVTPDWLEECFKR 923
Cdd:cd17731   11 TGFDSEerkEIQQLVEQN---GGSYsPDLSKNCTHLIAGSPS-GQKYEFARkwNSI-HIVTPEWLYDSIEA 76

BRCT_TopBP1_rpt6

cd17727

sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

101-169

1.79e-07

sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain.

Pssm-ID: 349359 [Multi-domain] Cd Length: 75 Bit Score: 49.52 E-value: 1.79e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81885070  101 GLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVP-EPKGEKYE-RAVKRTSIKIVTPDWVLDC 169
Cdd:cd17727    3 GVVICVSKKLSKRQGELNKIAASLGAEYRWTYDESCTHFIYQgKANDTNREyKSAKEQGKFIVSPHWLYAC 73

BRCT_2

pfam16589

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...

97-175

2.27e-07

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.

Pssm-ID: 465186 [Multi-domain] Cd Length: 84 Bit Score: 49.29 E-value: 2.27e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81885070     97 QIFFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAvkrTSIKIVTPDWVLDCVSEKRR 175
Cdd:pfam16589    3 NLFEPLRFYINAIPSPSRSKLKRLIEANGGTVVDNINPAVYIVIAPYNKTDKLAEN---TKLGVVSPQWIFDCVKKGKL 78

BRCT_CTDP1

cd17729

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...

856-923

4.22e-07

Pssm-ID: 349361 [Multi-domain] Cd Length: 97 Bit Score: 49.07 E-value: 4.22e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81885070  856 VLFTGFEPVQV---QQYIKKLYI-LGGEV-AECTKKCTHLIASKvTRTVKFLTAI-SVVKHIVTPDWLEECFKR 923
Cdd:cd17729   19 IVFSGVIPTGIdpeRSRLWKLAEsLGAKVvTDLSPRTTHLVAAK-LGTEKVKQALkMPGIHVVHPDWLWACAER 91

BRCT_2

pfam16589

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...

595-678

5.11e-07

Pssm-ID: 465186 [Multi-domain] Cd Length: 84 Bit Score: 48.52 E-value: 5.11e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070    595 GCVFAIADYPEqMSDKQLlatwKRIIQAHGGTVDPTFTSRCTHLLCASqvSSMYTQALRERKRCVTAHWLNTVLKKKKLM 674
Cdd:pfam16589    7 PLRFYINAIPS-PSRSKL----KRLIEANGGTVVDNINPAVYIVIAPY--NKTDKLAENTKLGVVSPQWIFDCVKKGKLL 79


                   ....
gi 81885070    675 PPHR 678
Cdd:pfam16589   80 PLEN 83

BRCT_DNA_ligase_IV_rpt1

cd17722

first BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed ...

98-174

1.40e-06

first BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed DNA ligase IV, or polydeoxyribonucleotide synthase [ATP] 4, is involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. It is a component of the LIG4-XRCC4 complex that is responsible for the NHEJ ligation step. LIG4 contains two BRCT domains. The family corresponds to the first one.

Pssm-ID: 349354 [Multi-domain] Cd Length: 90 Bit Score: 47.29 E-value: 1.40e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81885070   98 IFFGLTACLSQVSSE--DRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCVSEKR 174
Cdd:cd17722    1 IFEGVEFCVMSDMSSpkSKAELEKLIKENGGKVVQNPGAPDTICVIAGREVVKVKNLIKSGGHDVVKPSWLLDCIARKE 79

BRCT

breast cancer carboxy-terminal domain;

590-664

1.66e-06

breast cancer carboxy-terminal domain;

Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 46.60 E-value: 1.66e-06

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81885070     590 ESFLLGCVFAIADYPEQMSDKQLlatwKRIIQAHGGTVDPTFTS-RCTHLLCASQVSSMYT--QALRERKRCVTAHWL 664
Cdd:smart00292    1 PKLFKGKTFYITGSFDKEERDEL----KELIEALGGKVTSSLSSkTTTHVIVGSPEGGKLEllKAIALGIPIVKEEWL 74

BRCT_CHS5_like

cd17742

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...

101-174

2.10e-06

Pssm-ID: 349373 [Multi-domain] Cd Length: 77 Bit Score: 46.56 E-value: 2.10e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  101 GLTACLSQVS-SEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVkRTSIKIVTPDWVLDCVSEKR 174
Cdd:cd17742    2 GITVCLGPLDpPESVDELEQCLERIGAKPTDRVAIDTTHFVCTVPSGPEYEKAK-EMNIPIVRPEWLRACEVEKK 75

BRCT_PAXIP1_rpt2

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

871-929

3.29e-06

Pssm-ID: 349342 [Multi-domain] Cd Length: 81 Bit Score: 46.07 E-value: 3.29e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81885070  871 KKLY----ILGGEV-AECTKKCTHLIASKvTRTVKFLTAIsvvKH----IVTPDWLEECFKRQTFIDE 929
Cdd:cd17710   18 LKLWamvtFHGGKCqLNLDKKCTHLVTGK-ASGAKYECAL---KHegikIVTPDWVTDCIKAKTLLDE 81

BRCT_polymerase_lambda

cd17715

BRCT domain of DNA polymerase lambda and similar proteins; DNA polymerase lambda, also termed ...

99-175

4.82e-06

BRCT domain of DNA polymerase lambda and similar proteins; DNA polymerase lambda, also termed Pol Lambda, or DNA polymerase beta-2 (Pol beta2), or DNA polymerase kappa, is involved in base excision repair (BER) and is responsible for repair of lesions that give rise to abasic (AP) sites in DNA. It also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. DNA polymerase lambda has both template-dependent and template-independent (terminal transferase) DNA polymerase activities, as well as a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. DNA polymerase lambda contains one BRCT domain.

Pssm-ID: 349347 Cd Length: 80 Bit Score: 45.56 E-value: 4.82e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070   99 FFGLTACLS-QVSSEDRSALWA-LVTFHGGSCQLNLNKKCTHLIVPEpkGEKYERAVKRTS--IKIVTPDWVLDCVSEKR 174
Cdd:cd17715    1 FEGLTIHLVrTGIGRARAELFQrYIVQYGGQIVEDFGEGVTHVVVDD--GMDAERKVDRDPpgAQLVKSGWLSACIQEKR 78


                 .
gi 81885070  175 R 175
Cdd:cd17715   79 L 79

BRCT_Rad4_rpt4

cd17723

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...

101-173

8.57e-06

Pssm-ID: 349355 [Multi-domain] Cd Length: 74 Bit Score: 44.56 E-value: 8.57e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  101 GLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVP--EPKGEKYERAVKRtSIKIVTPDWVLDCVSEK 173
Cdd:cd17723    1 GLSISLTGFSGVDLLHISKLIKLLGAKYHESLTKDRSLLIVNstEKKSDKINFAKKW-GIPVVSVEWLWDCLKEG 74

BRCT_microcephalin_rpt1

cd17716

first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA ...

125-175

1.65e-05

first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat.

Pssm-ID: 349348 [Multi-domain] Cd Length: 78 Bit Score: 43.72 E-value: 1.65e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 81885070  125 GGSCQLNLNKKCTHLIVPEPKGEKYERAVKRtSIKIVTPDWVLDCVSEKRR 175
Cdd:cd17716   28 GAKVVKRLTKTVTHVVFKDGSQSTLEKAKKR-NVKLVSPLWVEACKETGKR 77

BRCT_Bard1_rpt1

cd17734

first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; ...

855-927

1.93e-05

first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; Bard1, also termed BARD-1, or RING-type E3 ubiquitin transferase BARD1, is a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers. It associates with BRCA1 (breast cancer-1) to form a heterodimeric BRCA1/BARD1 complex that is responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control. The BRCA1/BARD1 complex catalyzes autoubiquitination of BRCA1 and trans ubiquitination of other protein substrates. Its E3 ligase activity is dramatically reduced in the presence of UBX domain protein 1 (UBXN1). BARD-1 contains an N-terminal C3HC4-type RING-HC finger that binds BRCA1, and a C-terminal region with three ankyrin repeats and tandem BRCT domains that bind CstF-50 (cleavage stimulation factor) to modulate mRNA processing and RNAP II stability in response to DNA damage. The family corresponds to the first BRCT domain.

Pssm-ID: 349366 Cd Length: 80 Bit Score: 43.74 E-value: 1.93e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  855 LVLF-TGFEPVQVQQYIKKLYILGGEVA-ECTKKCTHLIAS-----KVTRTVKFLTAISVVKHIVTPDWLEECFKRQTFI 927
Cdd:cd17734    1 LVLLgSGLSSEQKKLLEKLAQLLKAKVVtEFSPEVTHVVVPadergVCPRTMKYLMGILAGKWIVSFEWVEACLKAKKLV 80

BRCT_Rev1

cd17719

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...

867-934

3.15e-05

Pssm-ID: 349351 [Multi-domain] Cd Length: 87 Bit Score: 43.33 E-value: 3.15e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885070  867 QQYIKKLYILGG---EVAECTKKCTHLIASKVTRT-VKFLTAISVVKhIVTPDWLEECFKRQTFIDEQNYIL 934
Cdd:cd17719   17 ADELKRLILLHGgqyEHYYSRSRVTHIIATNLPGSkIKKLKKARNYK-VVRPEWIVDSIKAGRLLPEAPYLL 87

BRCT_XRCC1_rpt1

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...

884-932

5.32e-05

Pssm-ID: 349357 [Multi-domain] Cd Length: 80 Bit Score: 42.65 E-value: 5.32e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 81885070  884 TKKCTHLIASKVtRTVKFLTAISVVKHIVTPDWLEECFKRQTFIDEQNY 932
Cdd:cd17725   33 TADCTHLICAFA-NTPKYKQVKGAGGIIVSKEWILDCYKKKKRLPWKRY 80

BRCT_TopBP1_rpt3

cd17718

third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

856-924

5.50e-05

third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the third BRCT domain.

Pssm-ID: 349350 Cd Length: 83 Bit Score: 42.58 E-value: 5.50e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885070  856 VLFTGFEPVQVQQyIKKLYILGGEV--AECTKKCTHLI-ASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQ 924
Cdd:cd17718   12 IYLSGFSGAELDK-LRRIINAGGGTrfNQLNESVTHVVvGESSEELLKELAKLAGRPHVVTPSWLLECFKQG 82

BRCT_BRC1_like_rpt4

cd18438

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...

106-170

7.00e-05

Pssm-ID: 349391 [Multi-domain] Cd Length: 68 Bit Score: 41.99 E-value: 7.00e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  106 LSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAvKRTSIKIVTPDWVLDCV 170
Cdd:cd18438    5 ITNYTGAARQYLEKLILALGATYTKNLKPDNTHLITASPEGEKYEAA-KEWNIPIVNHLWLYDSY 68

BRCT

breast cancer carboxy-terminal domain;

957-1040

7.86e-05

breast cancer carboxy-terminal domain;

Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 41.98 E-value: 7.86e-05

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070     957 SPLFKTKYFYITPGIC-PSLATMKAIVECAGGKVLAKQPSfrklmehkqnKSLSEIILISCENDLHLCREYFARGIDVHN 1035
Cdd:smart00292    1 PKLFKGKTFYITGSFDkEERDELKELIEALGGKVTSSLSS----------KTTTHVIVGSPEGGKLELLKAIALGIPIVK 70


                    ....*
gi 81885070    1036 AEFVL 1040
Cdd:smart00292   71 EEWLL 75

BRCT_DNA_ligase_III

cd18431

BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ...

98-177

1.39e-04

BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ligase III, or polydeoxyribonucleotide synthase [ATP] 3, functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.

Pssm-ID: 349384 [Multi-domain] Cd Length: 78 Bit Score: 41.15 E-value: 1.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070   98 IFFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKK-CTHLIVpepkgeKYERAVKRTSIKIVTPDWVLDCVSEKRRK 176
Cdd:cd18431    4 IFTGVKVYLPGSVEDDYKKLKRYFIAYDGDVVEEYDEEdATHVVV------DRDDKLGNPSAKVVSPEWLWDCIKKQKLV 77


                 .
gi 81885070  177 D 177
Cdd:cd18431   78 P 78

BRCT_BRC1_like_rpt1

cd18435

first (N-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) ...

133-183

1.50e-04

first (N-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.

Pssm-ID: 349388 Cd Length: 107 Bit Score: 42.31 E-value: 1.50e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  133 NKKCTHLIVPEPKGEKYERAVKRTSIK----IVTPDWVLDCVSEKRRKDEAFYHP 183
Cdd:cd18435   53 DPKLTHVILDDFDSPRVVELMKRTGKPrrlhLVKTKWIEDCVDENTLLDEEEYSP 107

BRCT_Bard1_rpt2

cd17720

second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar ...

124-171

1.54e-04

second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; Bard1, also termed BARD-1, or RING-type E3 ubiquitin transferase BARD1, is a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers. It associates with BRCA1 (breast cancer-1) to form a heterodimeric BRCA1/BARD1 complex that is responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control. The BRCA1/BARD1 complex catalyzes autoubiquitination of BRCA1 and trans ubiquitination of other protein substrates. Its E3 ligase activity is dramatically reduced in the presence of UBX domain protein 1 (UBXN1). BARD-1 contains an N-terminal C3HC4-type RING-HC finger that binds BRCA1, and a C-terminal region with three ankyrin repeats and tandem BRCT domains that bind CstF-50 (cleavage stimulation factor) to modulate mRNA processing and RNAP II stability in response to DNA damage. The family corresponds to the second BRCT domain.

Pssm-ID: 349352 Cd Length: 101 Bit Score: 41.97 E-value: 1.54e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 81885070  124 HGGSCQLNlnkkCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCVS 171
Cdd:cd17720   55 RPDSDLAN----CTHYIIYDKLNDKKPAKVRQGKVRVVPVSWLLDCIS 98

BRCT_SLF1

cd17750

BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins; ...

854-929

1.64e-04

BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins; SLF1, also termed Smc5/6 localization factor 1, or ankyrin repeat domain-containing protein 32 (ANKRD32), or BRCT domain-containing protein 1 (BRCTD1), plays a role in the DNA damage response (DDR) pathway by regulating post replication repair of UV-damaged DNA and genomic stability maintenance. It is a component of the SLF1-SLF2 complex that acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand break (DSB) sites on chromatin during DNA repair in response to stalled replication forks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.

Pssm-ID: 349381 Cd Length: 81 Bit Score: 41.34 E-value: 1.64e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  854 PLVLFTGFEPVQVQQYIKKLYILggevaECT-------KKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQTF 926
Cdd:cd17750    4 HIIQLTGFKGEEKEALVKLLLKL-----DCVfiksekyENCTHLIAKKPCRSEKFLAACAAGKWILTKDYIINSAKSGRW 78


                 ...
gi 81885070  927 IDE 929
Cdd:cd17750   79 LDE 81

BRCT_TopBP1_rpt7

cd17738

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...

106-173

1.99e-04

Pssm-ID: 349370 [Multi-domain] Cd Length: 75 Bit Score: 40.63 E-value: 1.99e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81885070  106 LSQVSSEDRSALWALVTFHGGSCQL--NLNKKCTHLIVPEPK-GEKYERAVKrTSIKIVTPDWVLDCVSEK 173
Cdd:cd17738    6 LSGFSEDEKKELISIIEKLGGKVLDsdEFDPKCTHLICGKPSrSEKFLAACA-AGKWILHPSYIEASAKAG 75

BRCT_microcephalin_rpt2

cd17736

second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage ...

864-927

2.24e-04

second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the second repeat.

Pssm-ID: 349368 [Multi-domain] Cd Length: 76 Bit Score: 40.65 E-value: 2.24e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070  864 VQVQQYIKKL--YILGGEVAECTkkcTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQTFI 927
Cdd:cd17736   14 ELLESVVKKLggFRVEDSVTEKT---THVVVGSPRRTLNVLLGIARGCWILSPDWVLESLEAGKWL 76

BRCT_PAXIP1_rpt2

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...

697-761

2.70e-04

Pssm-ID: 349342 [Multi-domain] Cd Length: 81 Bit Score: 40.68 E-value: 2.70e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070  697 IISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKA-KEWRIPCVNAQWLGD 761
Cdd:cd17710    6 VVCPSQISAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECAlKHEGIKIVTPDWVTD 71

BRCT_Ect2_rpt1

cd17733

first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar ...

112-166

3.37e-04

first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins; ECT2 is a guanine nucleotide exchange factor (GEF) for Rho GTPases, phosphorylated in G2/M phases, and is involved in the regulation of cytokinesis. It contains two tandem BRCT domains. The family corresponds to the first BRCT domain.

Pssm-ID: 349365 [Multi-domain] Cd Length: 76 Bit Score: 40.00 E-value: 3.37e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 81885070  112 EDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKrTSIKIVTPDWV 166
Cdd:cd17733   15 EELSRLVNLVHHMGGSIRKDFSSKVTHLVANSTQGEKYRVAVS-LGTPIMTEDWI 68

BRCT_TopBP1_rpt1

cd17737

first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

871-923

3.43e-04

first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the first BRCT domain.

Pssm-ID: 349369 [Multi-domain] Cd Length: 72 Bit Score: 40.09 E-value: 3.43e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 81885070  871 KKLYILGGEVA-ECTKKCTHLIASKVTrTVKFLTAISVVKHIVTPDWLEECFKR 923
Cdd:cd17737   19 KYVQLMGGRVSrDLTVSVTHLIAGEVG-SKKYLVAASLKKPIMLPSWVKTLWEK 71

BRCT_TopBP1_rpt1

cd17737

first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

101-166

4.21e-04

Pssm-ID: 349369 [Multi-domain] Cd Length: 72 Bit Score: 39.70 E-value: 4.21e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885070  101 GLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKrTSIKIVTPDWV 166
Cdd:cd17737    1 DVTISCTSLEKEEREEVHKYVQLMGGRVSRDLTVSVTHLIAGEVGSKKYLVAAS-LKKPIMLPSWV 65

BRCT_Rev1

cd17719

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...

617-675

4.64e-04

Pssm-ID: 349351 [Multi-domain] Cd Length: 87 Bit Score: 40.24 E-value: 4.64e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885070  617 KRIIQAHGGTVDPTFT-SRCTHLLcASQVSSMYTQALRERKRC--VTAHWLNTVLKKKKLMP 675
Cdd:cd17719   21 KRLILLHGGQYEHYYSrSRVTHII-ATNLPGSKIKKLKKARNYkvVRPEWIVDSIKAGRLLP 81

BRCT_BRC1_like_rpt1

cd18435

first (N-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) ...

870-932

9.50e-04

Pssm-ID: 349388 Cd Length: 107 Bit Score: 40.00 E-value: 9.50e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  870 IKKLYIL-GGEVAEC--TKKCTHLIA----SKVTRTVKFLTAISVVKHIVTPDWLEECFKRQTFIDEQNY 932
Cdd:cd18435   36 VEKLFIDnGGKILDLpyDPKLTHVILddfdSPRVVELMKRTGKPRRLHLVKTKWIEDCVDENTLLDEEEY 105

PTCB-BRCT

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...

617-663

9.54e-04

Pssm-ID: 463687 [Multi-domain] Cd Length: 63 Bit Score: 38.34 E-value: 9.54e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 81885070    617 KRIIQAHGGTVDPTFTSRCTHLLCASQVSSMYTQALRERKRCVTAHW 663
Cdd:pfam12738   17 QKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63

BRCT_polymerase_lambda

cd17715

BRCT domain of DNA polymerase lambda and similar proteins; DNA polymerase lambda, also termed ...

617-674

1.33e-03

Pssm-ID: 349347 Cd Length: 80 Bit Score: 38.63 E-value: 1.33e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 81885070  617 KRIIQAHGGTVDPTFTSRCTHLLCASQVS-SMYTQALRERKRCVTAHWLNTVLKKKKLM 674
Cdd:cd17715   22 QRYIVQYGGQIVEDFGEGVTHVVVDDGMDaERKVDRDPPGAQLVKSGWLSACIQEKRLV 80

BRCT_2

pfam16589

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...

865-932

2.44e-03

Pssm-ID: 465186 [Multi-domain] Cd Length: 84 Bit Score: 38.12 E-value: 2.44e-03

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81885070    865 QVQQYIKKLyilGGEVAEC-TKKCTHLIASKVTrtvKFLTAISVVKHIVTPDWLEECFKRQTFIDEQNY 932
Cdd:pfam16589   22 KLKRLIEAN---GGTVVDNiNPAVYIVIAPYNK---TDKLAENTKLGVVSPQWIFDCVKKGKLLPLENY 84

BRCT_TopBP1_rpt3

cd17718

third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...

95-174

2.55e-03

Pssm-ID: 349350 Cd Length: 83 Bit Score: 37.96 E-value: 2.55e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070   95 SCQIFfgltacLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPkGEKYERAVKRTSIK--IVTPDWVLDCVSE 172
Cdd:cd17718    9 GCKIY------LSGFSGAELDKLRRIINAGGGTRFNQLNESVTHVVVGES-SEELLKELAKLAGRphVVTPSWLLECFKQ 81


                 ..
gi 81885070  173 KR 174
Cdd:cd17718   82 GK 83

BRCT_XRCC1_rpt1

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...

697-778

2.96e-03

Pssm-ID: 349357 [Multi-domain] Cd Length: 80 Bit Score: 37.64 E-value: 2.96e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885070  697 IISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLGDIllgnFEALRQVQYS 776
Cdd:cd17725    3 VFVLSGFQNPFRGELRDKALEMGAKYRPDWTADCTHLICAFANTPKYKQVKGAGGIIVSKEWILDC----YKKKKRLPWK 78


                 ..
gi 81885070  777 RY 778
Cdd:cd17725   79 RY 80

BRCT_PAXIP1_rpt3