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Conserved domains on  [gi|158563975|sp|Q6P964|]
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RecName: Full=Serine/threonine-protein phosphatase 4 regulatory subunit 2-A

Protein Classification

serine/threonine-protein phosphatase 4 regulatory subunit 2( domain architecture ID 10557809)

serine/threonine-protein phosphatase 4 regulatory subunit 2 (PP4R2) is a regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process

Gene Ontology:  GO:0030289|GO:0019888

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP4R2 pfam09184
PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of ...
 9-250 6.13e-74

PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.


:

Pssm-ID: 462710  Cd Length: 256  Bit Score: 231.53  E-value: 6.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158563975    9 AFRDFEKKGEKESCPILDQFLSHVAKTGETMIQWSQFKSYFLFKLEKVMDDFKASCPEqrgpanpnvEYIPFEEMKQRIL 88
Cdd:pfam09184   1 ALEDFDKNMMGIISKELEQYLNHVAKTGDTMVLWSSFKPLFREKLENVIDHFTETIPE---------EIFNLEEMKERLL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158563975   89 KIVNGYNGIPFTIQRLCELLTEPKRNYAGTDKFLRGVEKNVMVVSCVYPTSEK------KGSSCVNRMNGVMfpgntsaf 162
Cdd:pfam09184  72 DKFDGFNGAPFTIQRICELLTDPFKYYKELDKFVRALEKNCLVVSTWDPGSERsesekdNGDSSDNRINGVM-------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158563975  163 pdrnvngpgtPRPLNRPKHSLSSNVATNGLPDSTESKE------------QASEQSE------RTVNESSASEAESHSGA 224
Cdd:pfam09184 144 ----------PDPLDVSLVSIPWSDETNGLPLSPFIKEidsimsvnfgfeDDDEDEDddgnesGTSASESEEITLSADSS 213

                         250       260       270
                  ....*....|....*....|....*....|.
gi 158563975  225 VKSKH-----RDDEDATHAETHEAKRLKFDK 250
Cdd:pfam09184 214 FKIEEkdddeEDDEEDDDYVEDEVDDEEEDD 244
 
Name Accession Description Interval E-value
PPP4R2 pfam09184
PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of ...
 9-250 6.13e-74

PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.


Pssm-ID: 462710  Cd Length: 256  Bit Score: 231.53  E-value: 6.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158563975    9 AFRDFEKKGEKESCPILDQFLSHVAKTGETMIQWSQFKSYFLFKLEKVMDDFKASCPEqrgpanpnvEYIPFEEMKQRIL 88
Cdd:pfam09184   1 ALEDFDKNMMGIISKELEQYLNHVAKTGDTMVLWSSFKPLFREKLENVIDHFTETIPE---------EIFNLEEMKERLL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158563975   89 KIVNGYNGIPFTIQRLCELLTEPKRNYAGTDKFLRGVEKNVMVVSCVYPTSEK------KGSSCVNRMNGVMfpgntsaf 162
Cdd:pfam09184  72 DKFDGFNGAPFTIQRICELLTDPFKYYKELDKFVRALEKNCLVVSTWDPGSERsesekdNGDSSDNRINGVM-------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158563975  163 pdrnvngpgtPRPLNRPKHSLSSNVATNGLPDSTESKE------------QASEQSE------RTVNESSASEAESHSGA 224
Cdd:pfam09184 144 ----------PDPLDVSLVSIPWSDETNGLPLSPFIKEidsimsvnfgfeDDDEDEDddgnesGTSASESEEITLSADSS 213

                         250       260       270
                  ....*....|....*....|....*....|.
gi 158563975  225 VKSKH-----RDDEDATHAETHEAKRLKFDK 250
Cdd:pfam09184 214 FKIEEkdddeEDDEEDDDYVEDEVDDEEEDD 244
 
Name Accession Description Interval E-value
PPP4R2 pfam09184
PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of ...
 9-250 6.13e-74

PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.


Pssm-ID: 462710  Cd Length: 256  Bit Score: 231.53  E-value: 6.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158563975    9 AFRDFEKKGEKESCPILDQFLSHVAKTGETMIQWSQFKSYFLFKLEKVMDDFKASCPEqrgpanpnvEYIPFEEMKQRIL 88
Cdd:pfam09184   1 ALEDFDKNMMGIISKELEQYLNHVAKTGDTMVLWSSFKPLFREKLENVIDHFTETIPE---------EIFNLEEMKERLL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158563975   89 KIVNGYNGIPFTIQRLCELLTEPKRNYAGTDKFLRGVEKNVMVVSCVYPTSEK------KGSSCVNRMNGVMfpgntsaf 162
Cdd:pfam09184  72 DKFDGFNGAPFTIQRICELLTDPFKYYKELDKFVRALEKNCLVVSTWDPGSERsesekdNGDSSDNRINGVM-------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158563975  163 pdrnvngpgtPRPLNRPKHSLSSNVATNGLPDSTESKE------------QASEQSE------RTVNESSASEAESHSGA 224
Cdd:pfam09184 144 ----------PDPLDVSLVSIPWSDETNGLPLSPFIKEidsimsvnfgfeDDDEDEDddgnesGTSASESEEITLSADSS 213

                         250       260       270
                  ....*....|....*....|....*....|.
gi 158563975  225 VKSKH-----RDDEDATHAETHEAKRLKFDK 250
Cdd:pfam09184 214 FKIEEkdddeEDDEEDDDYVEDEVDDEEEDD 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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