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Conserved domains on  [gi|81987372|sp|Q6UDJ2|]
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RecName: Full=Ribonucleoside-diphosphate reductase large subunit; Short=R1; AltName: Full=Ribonucleotide reductase large subunit

Protein Classification

ribonucleoside-diphosphate reductase large subunit( domain architecture ID 11494399)

ribonucleoside-diphosphate reductase large subunit (subunit alpha) catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

CATH:  3.20.70.20
EC:  1.17.4.1
Gene Ontology:  GO:0042802|GO:0061731|GO:0005524|GO:0009185|GO:0097718|GO:0005971
PubMed:  8511586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NrdE_NrdA TIGR02506
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ...
 170-786 0e+00

ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]


:

Pssm-ID: 274170 [Multi-domain]  Cd Length: 617  Bit Score: 733.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   170 NGRLESVGQFFLRIAAEAARGVANNDAF--AAAVFRDGTRAPDANTVFCLFFMALCRQEIVPPTPVMLFAGTESRSYASC 247
Cdd:TIGR02506   2 MGLKELYNRYLLRNAATGAIYESPQEAYmrVAMGLASLEPKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSSC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   248 FLLDVrGRHTRDVLTSIAEEIIPVMHSHGGIGLYMDCDSNWDD-------NSSGMMLALKALDSIIAASNAVSARPSGLC 320
Cdd:TIGR02506  82 FLLDV-TDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSpirgtnnASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   321 VYVEPWHRDIMKILRCRGVLaGNEETRCDNTFFALWMPDLFMKRFEANGTWTLFDGR-AAHLSDLYGEEFEKEYELLERK 399
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNN-GDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYdVPGLYGLYGEEFEEEYERLEKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   400 NVG---IATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRAMKCSNLCTEIVHMTDDES---VGVCNLTSLN 473
Cdd:TIGR02506 240 VEArkkIRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQPTDDSHkgeTAVCNLASVN 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   474 LAAFVTRRnalpgtppigTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDS 553
Cdd:TIGR02506 320 LANFVMED----------KFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDS 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   554 VEACRFNGKLFEALALTTFQTSCRIC-ELGmnPFRGFSESKYAKGWLHMDGWPARHLYF-------DGWDRLRENIKAYG 625
Cdd:TIGR02506 390 EEARDLNDRIFEAIYYYAIKASAELAkEKG--PFPGFSGSKYAKGWLHPDTWEKTIDPKtsmapteEDWEALRERIKEYG 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   626 LYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIQLNVALMETIECLYPNKAERR-DILERLHKNKWSTRg 704
Cdd:TIGR02506 468 LRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRgDIVENVGSPQPIAA- 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   705 afgaalPSQHPLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEddgaVRASRVAHLLTTAFKYGLKTgMYYCK 784
Cdd:TIGR02506 547 ------IPETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEE----VTAKDLLKLLLLAWKKGLKT-MYYCR 615


                  ..
gi 81987372   785 VR 786
Cdd:TIGR02506 616 SR 617
 
Name Accession Description Interval E-value
NrdE_NrdA TIGR02506
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ...
 170-786 0e+00

ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]


Pssm-ID: 274170 [Multi-domain]  Cd Length: 617  Bit Score: 733.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   170 NGRLESVGQFFLRIAAEAARGVANNDAF--AAAVFRDGTRAPDANTVFCLFFMALCRQEIVPPTPVMLFAGTESRSYASC 247
Cdd:TIGR02506   2 MGLKELYNRYLLRNAATGAIYESPQEAYmrVAMGLASLEPKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSSC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   248 FLLDVrGRHTRDVLTSIAEEIIPVMHSHGGIGLYMDCDSNWDD-------NSSGMMLALKALDSIIAASNAVSARPSGLC 320
Cdd:TIGR02506  82 FLLDV-TDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSpirgtnnASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   321 VYVEPWHRDIMKILRCRGVLaGNEETRCDNTFFALWMPDLFMKRFEANGTWTLFDGR-AAHLSDLYGEEFEKEYELLERK 399
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNN-GDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYdVPGLYGLYGEEFEEEYERLEKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   400 NVG---IATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRAMKCSNLCTEIVHMTDDES---VGVCNLTSLN 473
Cdd:TIGR02506 240 VEArkkIRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQPTDDSHkgeTAVCNLASVN 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   474 LAAFVTRRnalpgtppigTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDS 553
Cdd:TIGR02506 320 LANFVMED----------KFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDS 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   554 VEACRFNGKLFEALALTTFQTSCRIC-ELGmnPFRGFSESKYAKGWLHMDGWPARHLYF-------DGWDRLRENIKAYG 625
Cdd:TIGR02506 390 EEARDLNDRIFEAIYYYAIKASAELAkEKG--PFPGFSGSKYAKGWLHPDTWEKTIDPKtsmapteEDWEALRERIKEYG 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   626 LYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIQLNVALMETIECLYPNKAERR-DILERLHKNKWSTRg 704
Cdd:TIGR02506 468 LRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRgDIVENVGSPQPIAA- 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   705 afgaalPSQHPLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEddgaVRASRVAHLLTTAFKYGLKTgMYYCK 784
Cdd:TIGR02506 547 ------IPETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEE----VTAKDLLKLLLLAWKKGLKT-MYYCR 615


                  ..
gi 81987372   785 VR 786
Cdd:TIGR02506 616 SR 617
Ribonuc_red_lgC pfam02867
Ribonucleotide reductase, barrel domain;
245-782 0e+00

Ribonucleotide reductase, barrel domain;


Pssm-ID: 460729 [Multi-domain]  Cd Length: 487  Bit Score: 529.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   245 ASCFLLDVRgrhtrDVLTSIAEEIIPVM---HSHGGIGLYM-------DCDSNWDDNSSGMMLALKALDSIIAASNAVSA 314
Cdd:pfam02867   1 SSCFLLSVE-----DSLDSIYDTLKEAAllsKGGGGIGLNLsklrakgSPIRGTGGASSGVVPFLKLFDDSARYVNQGGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   315 RPSGLCVYVEPWHRDIMKILRCRgVLAGNEETRCDNTFFALWMPDLFMKRFEANGTWTLFDGRAA-HLSDLYGEEFEKE- 392
Cdd:pfam02867  76 RRGAAAVYLEVWHPDIEEFLDLK-KNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREApDLEDLYGEEFEKEy 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   393 YELLERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRaMKCSNLCTEIVHMTDDESVGVCNLTSL 472
Cdd:pfam02867 155 YEREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGT-IKSSNLCTEIVQPTSPSEIAVCNLASI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   473 NLAAFVTRRnalpgtppiGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLD 552
Cdd:pfam02867 234 NLAKFVEFG---------GTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYD 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   553 SVEACRFNGKLFEALALTTFQTSCRIC-ELGmnPFRGFSESKYAKGWLHMDGWP-------ARHLYFDgWDRLRENIKAY 624
Cdd:pfam02867 305 SEEARDLNDKIFETMYYYALKASSELAkEKG--PFPGFEGSKYSKGILQFDKYVktdfapkASKTRED-WEELREDIKKY 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   625 GLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTtgediqlnvalmetieclypnkaerrdilerlhknkwstrg 704
Cdd:pfam02867 382 GLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVL----------------------------------------- 420

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81987372   705 afgaalpSQHPLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEddgaVRASRVAHLLTTAFKYGLKTGMYY 782
Cdd:pfam02867 421 -------SEETKEYYKTAYDIDQKAHIDMAAARQPFVDQSISKTLFLPND----ATTSDLKSLYLYAWKLGLKTIYYY 487
NrdA COG0209
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ...
 156-790 2.19e-114

Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439979 [Multi-domain]  Cd Length: 665  Bit Score: 362.20  E-value: 2.19e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 156 SARKFESMYLGKLKNG-RLESVGQFFLRIAaeaaRGVANNDAFAAAVfrdgTRAPDantvfclFFMALCRQEIVPPTPVM 234
Cdd:COG0209  53 ALKTLYDRYLLKDEDGkPLETPQDLFMRVA----MGLAAAEKPEDRE----EWAKE-------FYDLLSSLRFLPATPTL 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 235 LFAGTESRSYASCFLLDVRgrhtrDVLTSIAEEIIPVM--HSH-GGIGLYMdcdSNwddnssgmmlaLKALDSIIAASNA 311
Cdd:COG0209 118 FNAGTPRGQLSSCFVLPVE-----DSLESIFDALKDAAllSKSgGGVGFNF---SR-----------LRPKGSPIKGTGG 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 312 VS---------------------ARPSGLCVYVEPWHRDIMKILRCRgVLAGNEETRCDNTFFALWMPDLFMKRFEANGT 370
Cdd:COG0209 179 VSsgpvpfmkvfddaavavnqggKRRGANMVYLRVWHPDIEEFLDLK-KNNGDERRRLHNFNISVWIPDLFMEAVEEDED 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 371 WTLFDGR-AAHLSDLYGEEFEKEYELLERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRaMKCS 449
Cdd:COG0209 258 WTLFSPReVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAWETGEPGILFKDTINRRNPLPHLGV-IHSS 336

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 450 NLCTEIVHMTDDESVGVCNLTSLNLAAFVTRrnalpgtppiGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNER 529
Cdd:COG0209 337 NLCGEIPLLPYESEDASCNLGSINLAKFVKD----------GEFDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKANRR 406

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 530 LRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRIC-ELGmnPFRGFSESKYAKGWLHMDGWPARH 608
Cdd:COG0209 407 HRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAkERG--AFPAFEGSKYAKGILPFDKYLDDL 484

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 609 L--YFDGWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSK-ITTTGEDIQLNVALMETIECL-YPN 684
Cdd:COG0209 485 LipTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRkVLDGGEFTVVNPYLVRALKELgLWD 564

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 685 KAERRDILErlhknKWSTRGAfgAALPSQHpLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEddgaVRASRV 764
Cdd:COG0209 565 EELVEKIKE-----DGSVQDI--DELPEEL-KELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPND----ATVEDL 632

                       650       660
                ....*....|....*....|....*.
gi 81987372 765 AHLLTTAFKYGLKTgMYYCKVRKATD 790
Cdd:COG0209 633 AELYLLAWKLGLKG-IYYYRDGSRTG 657
PLN02437 PLN02437
ribonucleoside--diphosphate reductase large subunit
 231-790 9.16e-90

ribonucleoside--diphosphate reductase large subunit


Pssm-ID: 178056 [Multi-domain]  Cd Length: 813  Bit Score: 300.89  E-value: 9.16e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  231 TPVMLFAGTESRSYASCFLLDVRGrhtrDVLTSIAE---EIIPVMHSHGGIGLYMDCdsnwddnssgmmlaLKALDSIIA 307
Cdd:PLN02437 202 SPTLFNAGTPRPQLSSCFLICMKD----DSIEGIYDtlkECAVISKSAGGIGLSVHN--------------IRATGSYIR 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  308 ASNAVS----------------------ARPSGLCVYVEPWHRDIMKILRCRGVlAGNEETRCDNTFFALWMPDLFMKRF 365
Cdd:PLN02437 264 GTNGTSngivpmlrvfndtaryvdqgggKRKGAFAIYLEPWHADIFEFLDLRKN-HGKEEHRARDLFYALWIPDLFMERV 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  366 EANGTWTLF-DGRAAHLSDLYGEEFEKEYELLERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGr 444
Cdd:PLN02437 343 QSNGDWSLFcPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQNLG- 421

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  445 AMKCSNLCTEIVHMTDDESVGVCNLTSLNLAAFVTRRNALPGTPPIG----------TFDYSSFRDACAVATVFINALMS 514
Cdd:PLN02437 422 TIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVREKGVPLESHPSKlvgslgsknrYFDFEKLAEVTAVVTRNLNKIID 501

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  515 LSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRICELGmNPFRGFSESKY 594
Cdd:PLN02437 502 VNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAARE-GPYETYAGSPV 580

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  595 AKGWLHMDGW---PA-RHlyfdGWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIQL 670
Cdd:PLN02437 581 SKGILQPDMWgvtPSgRW----DWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEFVVV 656

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  671 NVALMetieclypNKAERRDILERLHKNKWSTRGAFGAALPSQHPLTK--FDTAFEADQEHLLRLSADRAPFVDHSQSTT 748
Cdd:PLN02437 657 NKHLL--------HDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKaiYKTVWEIKQRTLVDMAADRGCYIDQSQSLN 728

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*.
gi 81987372  749 LYVVEEDDGAvrasrvahlLTT----AFKYGLKTGMYYCKVRKATD 790
Cdd:PLN02437 729 IHMDQPNFGK---------LTSlhfyAWSKGLKTGMYYLRSRAAAD 765
RNR_I cd01679
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ...
 218-783 1.85e-80

Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.


Pssm-ID: 153088 [Multi-domain]  Cd Length: 460  Bit Score: 265.95  E-value: 1.85e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 218 FFMALCRQEIVPPTPVMLFAGTESRSYASCFLLDVRgrhtrDVLTSIAEEIIPVM---HSHGGIGLYMDC---------- 284
Cdd:cd01679  23 FYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVD-----DSLESIYDTIKECAqlsKIGGGIGLNLSNiratgspirg 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 285 DSNwddNSSGMMLALKALDSIIAASNAVSARPSGLCVYVEPWHRDIMKILRCRgVLAGNEETRCDNTFFALWMPDLFMKR 364
Cdd:cd01679  98 TNG---ASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLK-KNNGDERRRARDLFYGVWIPDLFMER 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 365 FEangtwtlfdgraahlsdlygeefekeyellerknvgiatypaRDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGR 444
Cdd:cd01679 174 VE------------------------------------------RDLWRKILESQFETGYPYILFKDTCNRKNPQKHLGT 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 445 aMKCSNLCTEIV------HMTDDESVgVCNLTSLNLAAFVTrrnalpgtppigtfdYSSFRDACAVATVFINALMSLSNL 518
Cdd:cd01679 212 -IKSSNLCTEILqptspsEDEPGEDA-VCNLASINLGNFVT---------------FEKLEEVVKLAVRALDNVIDLNYY 274

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 519 PIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRICELgmnpfRGfseskyakgw 598
Cdd:cd01679 275 PVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKE-----RG---------- 339

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 599 lhmdgwparhlyfdgwdrlrenikayGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIqlnvalmeti 678
Cdd:cd01679 340 --------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFP---------- 383

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 679 eclYPNKAerrdiLERLHKnkwstrgafgaalpsqhPLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVveedDGA 758
Cdd:cd01679 384 ---VVNPH-----LEKDLW-----------------EYGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFL----TPP 434

                       570       580
                ....*....|....*....|....*
gi 81987372 759 VRASRVAHLLTTAFKYGLKTGmYYC 783
Cdd:cd01679 435 ATTRDLNSLYFYAWKKGLKTL-YYL 458
 
Name Accession Description Interval E-value
NrdE_NrdA TIGR02506
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ...
 170-786 0e+00

ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]


Pssm-ID: 274170 [Multi-domain]  Cd Length: 617  Bit Score: 733.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   170 NGRLESVGQFFLRIAAEAARGVANNDAF--AAAVFRDGTRAPDANTVFCLFFMALCRQEIVPPTPVMLFAGTESRSYASC 247
Cdd:TIGR02506   2 MGLKELYNRYLLRNAATGAIYESPQEAYmrVAMGLASLEPKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSSC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   248 FLLDVrGRHTRDVLTSIAEEIIPVMHSHGGIGLYMDCDSNWDD-------NSSGMMLALKALDSIIAASNAVSARPSGLC 320
Cdd:TIGR02506  82 FLLDV-TDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSpirgtnnASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   321 VYVEPWHRDIMKILRCRGVLaGNEETRCDNTFFALWMPDLFMKRFEANGTWTLFDGR-AAHLSDLYGEEFEKEYELLERK 399
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNN-GDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYdVPGLYGLYGEEFEEEYERLEKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   400 NVG---IATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRAMKCSNLCTEIVHMTDDES---VGVCNLTSLN 473
Cdd:TIGR02506 240 VEArkkIRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQPTDDSHkgeTAVCNLASVN 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   474 LAAFVTRRnalpgtppigTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDS 553
Cdd:TIGR02506 320 LANFVMED----------KFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDS 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   554 VEACRFNGKLFEALALTTFQTSCRIC-ELGmnPFRGFSESKYAKGWLHMDGWPARHLYF-------DGWDRLRENIKAYG 625
Cdd:TIGR02506 390 EEARDLNDRIFEAIYYYAIKASAELAkEKG--PFPGFSGSKYAKGWLHPDTWEKTIDPKtsmapteEDWEALRERIKEYG 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   626 LYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIQLNVALMETIECLYPNKAERR-DILERLHKNKWSTRg 704
Cdd:TIGR02506 468 LRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRgDIVENVGSPQPIAA- 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   705 afgaalPSQHPLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEddgaVRASRVAHLLTTAFKYGLKTgMYYCK 784
Cdd:TIGR02506 547 ------IPETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEE----VTAKDLLKLLLLAWKKGLKT-MYYCR 615


                  ..
gi 81987372   785 VR 786
Cdd:TIGR02506 616 SR 617
Ribonuc_red_lgC pfam02867
Ribonucleotide reductase, barrel domain;
245-782 0e+00

Ribonucleotide reductase, barrel domain;


Pssm-ID: 460729 [Multi-domain]  Cd Length: 487  Bit Score: 529.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   245 ASCFLLDVRgrhtrDVLTSIAEEIIPVM---HSHGGIGLYM-------DCDSNWDDNSSGMMLALKALDSIIAASNAVSA 314
Cdd:pfam02867   1 SSCFLLSVE-----DSLDSIYDTLKEAAllsKGGGGIGLNLsklrakgSPIRGTGGASSGVVPFLKLFDDSARYVNQGGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   315 RPSGLCVYVEPWHRDIMKILRCRgVLAGNEETRCDNTFFALWMPDLFMKRFEANGTWTLFDGRAA-HLSDLYGEEFEKE- 392
Cdd:pfam02867  76 RRGAAAVYLEVWHPDIEEFLDLK-KNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREApDLEDLYGEEFEKEy 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   393 YELLERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRaMKCSNLCTEIVHMTDDESVGVCNLTSL 472
Cdd:pfam02867 155 YEREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGT-IKSSNLCTEIVQPTSPSEIAVCNLASI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   473 NLAAFVTRRnalpgtppiGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLD 552
Cdd:pfam02867 234 NLAKFVEFG---------GTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYD 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   553 SVEACRFNGKLFEALALTTFQTSCRIC-ELGmnPFRGFSESKYAKGWLHMDGWP-------ARHLYFDgWDRLRENIKAY 624
Cdd:pfam02867 305 SEEARDLNDKIFETMYYYALKASSELAkEKG--PFPGFEGSKYSKGILQFDKYVktdfapkASKTRED-WEELREDIKKY 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   625 GLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTtgediqlnvalmetieclypnkaerrdilerlhknkwstrg 704
Cdd:pfam02867 382 GLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVL----------------------------------------- 420

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81987372   705 afgaalpSQHPLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEddgaVRASRVAHLLTTAFKYGLKTGMYY 782
Cdd:pfam02867 421 -------SEETKEYYKTAYDIDQKAHIDMAAARQPFVDQSISKTLFLPND----ATTSDLKSLYLYAWKLGLKTIYYY 487
NrdA COG0209
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ...
 156-790 2.19e-114

Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439979 [Multi-domain]  Cd Length: 665  Bit Score: 362.20  E-value: 2.19e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 156 SARKFESMYLGKLKNG-RLESVGQFFLRIAaeaaRGVANNDAFAAAVfrdgTRAPDantvfclFFMALCRQEIVPPTPVM 234
Cdd:COG0209  53 ALKTLYDRYLLKDEDGkPLETPQDLFMRVA----MGLAAAEKPEDRE----EWAKE-------FYDLLSSLRFLPATPTL 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 235 LFAGTESRSYASCFLLDVRgrhtrDVLTSIAEEIIPVM--HSH-GGIGLYMdcdSNwddnssgmmlaLKALDSIIAASNA 311
Cdd:COG0209 118 FNAGTPRGQLSSCFVLPVE-----DSLESIFDALKDAAllSKSgGGVGFNF---SR-----------LRPKGSPIKGTGG 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 312 VS---------------------ARPSGLCVYVEPWHRDIMKILRCRgVLAGNEETRCDNTFFALWMPDLFMKRFEANGT 370
Cdd:COG0209 179 VSsgpvpfmkvfddaavavnqggKRRGANMVYLRVWHPDIEEFLDLK-KNNGDERRRLHNFNISVWIPDLFMEAVEEDED 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 371 WTLFDGR-AAHLSDLYGEEFEKEYELLERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRaMKCS 449
Cdd:COG0209 258 WTLFSPReVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAWETGEPGILFKDTINRRNPLPHLGV-IHSS 336

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 450 NLCTEIVHMTDDESVGVCNLTSLNLAAFVTRrnalpgtppiGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNER 529
Cdd:COG0209 337 NLCGEIPLLPYESEDASCNLGSINLAKFVKD----------GEFDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKANRR 406

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 530 LRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRIC-ELGmnPFRGFSESKYAKGWLHMDGWPARH 608
Cdd:COG0209 407 HRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAkERG--AFPAFEGSKYAKGILPFDKYLDDL 484

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 609 L--YFDGWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSK-ITTTGEDIQLNVALMETIECL-YPN 684
Cdd:COG0209 485 LipTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRkVLDGGEFTVVNPYLVRALKELgLWD 564

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 685 KAERRDILErlhknKWSTRGAfgAALPSQHpLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEddgaVRASRV 764
Cdd:COG0209 565 EELVEKIKE-----DGSVQDI--DELPEEL-KELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPND----ATVEDL 632

                       650       660
                ....*....|....*....|....*.
gi 81987372 765 AHLLTTAFKYGLKTgMYYCKVRKATD 790
Cdd:COG0209 633 AELYLLAWKLGLKG-IYYYRDGSRTG 657
PLN02437 PLN02437
ribonucleoside--diphosphate reductase large subunit
 231-790 9.16e-90

ribonucleoside--diphosphate reductase large subunit


Pssm-ID: 178056 [Multi-domain]  Cd Length: 813  Bit Score: 300.89  E-value: 9.16e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  231 TPVMLFAGTESRSYASCFLLDVRGrhtrDVLTSIAE---EIIPVMHSHGGIGLYMDCdsnwddnssgmmlaLKALDSIIA 307
Cdd:PLN02437 202 SPTLFNAGTPRPQLSSCFLICMKD----DSIEGIYDtlkECAVISKSAGGIGLSVHN--------------IRATGSYIR 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  308 ASNAVS----------------------ARPSGLCVYVEPWHRDIMKILRCRGVlAGNEETRCDNTFFALWMPDLFMKRF 365
Cdd:PLN02437 264 GTNGTSngivpmlrvfndtaryvdqgggKRKGAFAIYLEPWHADIFEFLDLRKN-HGKEEHRARDLFYALWIPDLFMERV 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  366 EANGTWTLF-DGRAAHLSDLYGEEFEKEYELLERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGr 444
Cdd:PLN02437 343 QSNGDWSLFcPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQNLG- 421

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  445 AMKCSNLCTEIVHMTDDESVGVCNLTSLNLAAFVTRRNALPGTPPIG----------TFDYSSFRDACAVATVFINALMS 514
Cdd:PLN02437 422 TIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVREKGVPLESHPSKlvgslgsknrYFDFEKLAEVTAVVTRNLNKIID 501

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  515 LSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRICELGmNPFRGFSESKY 594
Cdd:PLN02437 502 VNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAARE-GPYETYAGSPV 580

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  595 AKGWLHMDGW---PA-RHlyfdGWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIQL 670
Cdd:PLN02437 581 SKGILQPDMWgvtPSgRW----DWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEFVVV 656

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  671 NVALMetieclypNKAERRDILERLHKNKWSTRGAFGAALPSQHPLTK--FDTAFEADQEHLLRLSADRAPFVDHSQSTT 748
Cdd:PLN02437 657 NKHLL--------HDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKaiYKTVWEIKQRTLVDMAADRGCYIDQSQSLN 728

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*.
gi 81987372  749 LYVVEEDDGAvrasrvahlLTT----AFKYGLKTGMYYCKVRKATD 790
Cdd:PLN02437 729 IHMDQPNFGK---------LTSlhfyAWSKGLKTGMYYLRSRAAAD 765
RNR_I cd01679
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ...
 218-783 1.85e-80

Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.


Pssm-ID: 153088 [Multi-domain]  Cd Length: 460  Bit Score: 265.95  E-value: 1.85e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 218 FFMALCRQEIVPPTPVMLFAGTESRSYASCFLLDVRgrhtrDVLTSIAEEIIPVM---HSHGGIGLYMDC---------- 284
Cdd:cd01679  23 FYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVD-----DSLESIYDTIKECAqlsKIGGGIGLNLSNiratgspirg 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 285 DSNwddNSSGMMLALKALDSIIAASNAVSARPSGLCVYVEPWHRDIMKILRCRgVLAGNEETRCDNTFFALWMPDLFMKR 364
Cdd:cd01679  98 TNG---ASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLK-KNNGDERRRARDLFYGVWIPDLFMER 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 365 FEangtwtlfdgraahlsdlygeefekeyellerknvgiatypaRDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGR 444
Cdd:cd01679 174 VE------------------------------------------RDLWRKILESQFETGYPYILFKDTCNRKNPQKHLGT 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 445 aMKCSNLCTEIV------HMTDDESVgVCNLTSLNLAAFVTrrnalpgtppigtfdYSSFRDACAVATVFINALMSLSNL 518
Cdd:cd01679 212 -IKSSNLCTEILqptspsEDEPGEDA-VCNLASINLGNFVT---------------FEKLEEVVKLAVRALDNVIDLNYY 274

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 519 PIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRICELgmnpfRGfseskyakgw 598
Cdd:cd01679 275 PVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKE-----RG---------- 339

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 599 lhmdgwparhlyfdgwdrlrenikayGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIqlnvalmeti 678
Cdd:cd01679 340 --------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFP---------- 383

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 679 eclYPNKAerrdiLERLHKnkwstrgafgaalpsqhPLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVveedDGA 758
Cdd:cd01679 384 ---VVNPH-----LEKDLW-----------------EYGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFL----TPP 434

                       570       580
                ....*....|....*....|....*
gi 81987372 759 VRASRVAHLLTTAFKYGLKTGmYYC 783
Cdd:cd01679 435 ATTRDLNSLYFYAWKKGLKTL-YYL 458
PRK12365 PRK12365
ribonucleoside-diphosphate reductase subunit alpha;
164-789 8.21e-63

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 171440 [Multi-domain]  Cd Length: 1046  Bit Score: 229.06  E-value: 8.21e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   164 YLGKLKNGRLESVGQFFLRIAAeaarGVANNDAfaaavfrdgtraPDANTVFCLFFMALCRQEIVPPTPVMLFAGTESRS 243
Cdd:PRK12365  390 YFNHHEGRRLETPQIFWMRVSM----GLALNEG------------QDKTSWAITFYNLLSTFRYTPATPTLFNSGMRHSQ 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   244 YASCFLLDVRgrhtrDVLTSIAEEIIP-VMHSH--GGIGlymdcdSNWDD-------------NSSGMMLALKALDSIIA 307
Cdd:PRK12365  454 LSSCYLSTVQ-----DDLVHIYKVISDnAMLSKwaGGIG------NDWTAvratgalikgtngKSQGVIPFIKVANDTAV 522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   308 ASNAVSARPSGLCVYVEPWHRDIMKILRCRGVlAGNEETRCDNTFFALWMPDLFMKRFEANGTWTLFD-GRAAHLSDLYG 386
Cdd:PRK12365  523 AVNQGGKRKGAVCVYLEVWHLDYEDFLELRKN-TGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSpDDVPGLHEAYG 601

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   387 EEFEKEYELLERK--NVGIATY---PARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGrAMKCSNLCTEIVHMTDD 461
Cdd:PRK12365  602 EEFEKLYEEYERKvdTGEIRLYkkvEAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHKG-VVRCSNLCTEILLNCSE 680

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   462 ESVGVCNLTSLNLAAFVTRrnalpgtppiGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFH 541
Cdd:PRK12365  681 TETAVCNLGSINLVEHIVN----------DGLDEEKLSETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQ 750

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   542 TACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRIC-ELGMnpFRGFSESKYAKGWLHMDGWP-------ARHLYFD- 612
Cdd:PRK12365  751 DALYKLNISYASQEAVEFADYSSELIAYYAILASSLLAkERGT--YSSYKGSKWDRGYLPIDTIEllkeyrgEANLLMDt 828

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   613 ----GWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIQLNVALMETIECLYPNKAER 688
Cdd:PRK12365  829 ssrkDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGVTQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADM 908

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   689 RDILERLHknkwstrgafGAALPSQ----HPLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEDdgavrASRV 764
Cdd:PRK12365  909 LDDLKYFD----------GSLLEIEripdHLKKIFLTAFEIEPEWIIECASRRQKWIDMGQSLNLYLAEPD-----GKKL 973

                         650       660
                  ....*....|....*....|....*
gi 81987372   765 AHLLTTAFKYGLKTgMYYCKVRKAT 789
Cdd:PRK12365  974 SNMYLTAWKKGLKT-TYYLRSSAAT 997
PRK06539 PRK06539
ribonucleoside-diphosphate reductase subunit alpha;
164-781 8.60e-51

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 180610 [Multi-domain]  Cd Length: 822  Bit Score: 191.67  E-value: 8.60e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  164 YLGKLKNGRLESVGQFF-LRIAAeaarGVANNDafaaavfRDGTRAPDAntvfclFFMALCRQEIVPPTPVMLFAGTESR 242
Cdd:PRK06539 160 YGIRARNGDALEVPQYFwMRIAM----GLSLNE-------DDPTSSALA------FYEKMSKLEYLAAGSTLVNAGTPYP 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  243 SYASCFLLDvrgrhTRDVLTSIAEEIIPVM---HSHGGIGLYMD--------CDSNwDDNSSGMMLALKALDSIIAASNA 311
Cdd:PRK06539 223 QLSNCFVME-----MQDDIEHIAKTTRDVMwltKGTGGIGLSVSklraqgspIRSN-NTTSTGPIPFMHTIDSVLRAVSR 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  312 VSARPSGLCVYVEPWHRDIMKILRCRGVlAGN--EETRCDNTffALWMPDLFMKRFEANGTWTLFD-GRAAHLSDLYGEE 388
Cdd:PRK06539 297 GGKKFGALCFYMENWHMDFPEFLDLRQN-SGDpyRRTRTANT--AVWISDEFMKRVQNDEDWYLFDpLETPDLNELYGKA 373

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  389 FEKEYE-LLERKNVG----IATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGrAMKCSNLCTEIVHMTDDES 463
Cdd:PRK06539 374 FSKRYAqYVEQAEAGrirmFKRITAREQFRAILMSLQTTSHPWLTWKDTINNRALNNNTG-TIHLSNLCTEICLPQDRDN 452

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  464 VGVCNLTSLNLAAFVTRrnalpgtppiGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTA 543
Cdd:PRK06539 453 VSVCNLASINLSRHLAD----------GELDWAQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDM 522

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  544 CLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRICElGMNPFRGFSESKYAKGWLHMD---------GWPA---RHLYF 611
Cdd:PRK06539 523 VERLGYSYESEEAYDLIDRIMEHISYAAIDESADLAA-ERGAYPNFEGSRWSRGMVPVDsialleadrGVPVdvnRTTRL 601

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  612 DgWDRLRENIKAyGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIQLNVALMETIeclypnkaERRDI 691
Cdd:PRK06539 602 D-WDALRAKVRG-GMRNATLMAIAPTASIGLVAGTTPGLDPQFSQIFSRSTSSGKFLEVNRNLVADL--------KELGL 671

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  692 LERLHKNKWSTRGAFG--AALPSqHPLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEDDGavrasRVAHLLT 769
Cdd:PRK06539 672 WETVREEILRSQGDIQeiAAIPD-EIKALYRTSFQLSPYAFLEVAARAQKWVDQAISRNMYLESRDIG-----DMMDIYT 745

                        650
                 ....*....|..
gi 81987372  770 TAFKYGLKTGMY 781
Cdd:PRK06539 746 AAWEMGVKTTYY 757
PRK09209 PRK09209
ribonucleoside-diphosphate reductase subunit alpha;
231-782 1.25e-50

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 181700 [Multi-domain]  Cd Length: 761  Bit Score: 190.32  E-value: 1.25e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  231 TPVMLFAGTESRSYASCFLLDVRgrhtrDVLTSIAE---EIIPVMHSHGGIGLYM------DCD-SNWDDNSSGMMLALK 300
Cdd:PRK09209 221 TPTLANAGKVGGQLSSCFIDTVD-----DSLQGIYDsntDVARVSKHGGGVGAYLgkvrsrGSDiRGFKGVSSGVIPWIK 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  301 ALDSIIAASNAVSARPSGLCVYVEPWHRDIMKILRCRgVLAGNEETRCDNTFFALWMPDLFMKRFEANGTWTLFDgraAH 380
Cdd:PRK09209 296 QLNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLR-LNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFD---PH 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  381 ---------LSDLYGEE-----FEKEYE------LLERKnvgiaTYPARDVMFALIKSAVSTGTPFVMFKHAVNR---NY 437
Cdd:PRK09209 372 evkkvmgwyLEDFYDEKkgdgsFREKYEecvadeRLSRK-----TVKAIDIMKRIMVSQLETGNPFMFYRDEVNRmnpNK 446

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  438 FFDMagraMKCSNLCTEIVH----------MTDDESV------G---VCNLTSLNLAAFVTrRNALPGTPPIgtfdysSF 498
Cdd:PRK09209 447 HEGM----IYSSNLCTEIMQnmsptvmiqeIISGGQIvitkqpGdfvVCNLSSINLGRAVT-ADVLERLIPI------QV 515

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  499 RdacavatvFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRI 578
Cdd:PRK09209 516 R--------MLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMEL 587

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  579 C-ELGMNP-FRGfSEskyakgWLHMDGWPARHLYFDGWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFGN 656
Cdd:PRK09209 588 AkEKGAYPvFKG-SD------WQTGEYFERRGYNSPQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDPIYSA 660

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  657 IFS------KITTTGEDIQLnvalmETIecLYPNKaerrdilerlhknkwstrgafgaalpsqhpltkfdTAFEADQEHL 730
Cdd:PRK09209 661 FYYeekkdyRRPVTAPDLSL-----DTW--PYYEK-----------------------------------GAYKVDQFWS 698

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|..
gi 81987372  731 LRLSADRAPFVDHSQSTTLYVVEeddgAVRASRVAHLLTTAFKYGLKTgMYY 782
Cdd:PRK09209 699 IRQNAARQRHVDQSISFNFYVPS----TIRASELLDLHMTAWKEGLKT-TYY 745
PRK07207 PRK07207
ribonucleoside-diphosphate reductase subunit alpha;
292-811 1.93e-43

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 235966 [Multi-domain]  Cd Length: 965  Bit Score: 170.14  E-value: 1.93e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  292 SSGMMLALKALDSIIAASNAVSARPSGLCVYVEPWHRDIMKILRCRGVlAGNEETRCD--NTffALWMPDLFMKRFEANG 369
Cdd:PRK07207 424 SQGVVPFLKVVNDTAVAVNQGGKRKGAVCAYLETWHLDIEEFLELRKN-TGDDRRRTHdmNT--ANWIPDLFMKRVMEDG 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  370 TWTLFD-GRAAHLSDLYGEEFEKEYELLERKnvgiA---------TYPARDV---MFALIksaVSTGTPFVMFKHAVNRN 436
Cdd:PRK07207 501 EWTLFSpSEVPDLHDLFGKAFEEAYTAYEAK----AargeiklfkKIPAVDLwrkMLSML---FETGHPWITFKDPCNLR 573

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  437 YFFDMAGrAMKCSNLCTEIVHMTDDESVGVCNLTSLNLAAFVTRRNALpgtppigtfDYSSFRDACAVATVFINALMSLS 516
Cdd:PRK07207 574 SPQQHVG-VVHSSNLCTEITLNTSDDEIAVCNLGSVNLVAHIKDGAKL---------DHEKLKRTVSTAMRMLDNVIDIN 643

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  517 NLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRIC-ELGMNP-FRGfseSKY 594
Cdd:PRK07207 644 YYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSYYAIWASTELAeERGRYSsYEG---SLW 720

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  595 AKGWLHMDGW----PARHLYFD-------GWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITT 663
Cdd:PRK07207 721 SRGILPIDSLkllaEARGGYLEvdrsstlDWDALRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPTYQNLYVKSNL 800

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  664 TGEDIQLNVALMetieclypnkaerRDILERlhkNKWSTR---------GAFGAA--LPSQhpLTK-FDTAFEADQEHLL 731
Cdd:PRK07207 801 SGEFTVVNPYLV-------------RDLKAR---GLWDEVmvndlkyfdGSLQRIdrIPAD--LKAlYATAFEVDPRWLV 862

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  732 RLSADRAPFVDHSQSTTLYVVEeddgavrAS--RVAHLLTTAFKYGLKTgMYYCKVRKATD-----------NGVFLGTD 798
Cdd:PRK07207 863 EAASRRQKWIDQAQSLNLYMAG-------ASgkKLDETYKLAWLRGLKT-TYYLRTLGATHvekstvntgalNAVSSGGG 934

                        570       580       590
                 ....*....|....*....|....*....|.
gi 81987372  799 T------------------CRRDDPTCLACQ 811
Cdd:PRK07207 935 GaggaaaaaaappaadpkaCSIDDPDCEACQ 965
PRK07088 PRK07088
ribonucleoside-diphosphate reductase subunit alpha;
231-782 4.04e-43

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 180831 [Multi-domain]  Cd Length: 764  Bit Score: 168.06  E-value: 4.04e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  231 TPVMLFAGTESRSYASCFLlDVRGrhtrDVLTSI---AEEIIPVMHSHGGIGLYM------DCDSNWDDNSSGMMLALKA 301
Cdd:PRK07088 223 TPTLSNAGTPFYQLSSCFI-SVVD----DNLWSIydvNQKFAQVSKHGGALGIYTgkiralNSEIRGFKNASGGVIPWIK 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  302 L--DSIIAAsNAVSARPSGLCVYVEPWHRDIMKILRCRgVLAGNEETRCDNTFFALWMPDLFMKRFEANGTWTLFDG--- 376
Cdd:PRK07088 298 LynDTAIAV-DQLGKRKGGAAITLDIWHKDIPEFLDLK-TNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPhei 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  377 ---RAAHLSDLYGE----EFEKEY-ELLERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGrAMKC 448
Cdd:PRK07088 376 kkvKGYSLEDYYDEedrkEFTKKYlECEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKG-MIYS 454

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  449 SNLCTEIV-HMTDDESVG----------------------VCNLTSLNLaafvtrrnalpgtppiGTFDYSSFRDACAVA 505
Cdd:PRK07088 455 SNLCHEIAqNMSESELLEeeiidengyyevvqkikagdmvTCNLNSIVL----------------GNVDDEELEEVIPTQ 518

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  506 TVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRIC-ELGMN 584
Cdd:PRK07088 519 IRMLDNVISLNYYPVPEAEITSDKYRAIGLGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAkEKGSY 598

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  585 P-FRGfSEskyakgWLHMDGWPARHLYFDGWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFskitt 663
Cdd:PRK07088 599 PaFKG-SE------WETGKYFERRGYNSERWKKLKEEIKKYGMRNGYITAVAPTGSTSNIANTTAGIDPVFKRFF----- 666

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  664 tgediqlnvaLMETIECLYPNKAErrDILErlhKNKWStrgafgaalpsqhpltkFDTAFEADQEHLLRLSADRAPFVDH 743
Cdd:PRK07088 667 ----------MEEKKGSFTPKTAP--DLNE---ENFWY-----------------YKEAHTIDQQWSIKACGVRQRHIDQ 714

                        570       580       590
                 ....*....|....*....|....*....|....*....
gi 81987372  744 SQSTTLYVVEEddgaVRASRVAHLLTTAFKYGLKTgMYY 782
Cdd:PRK07088 715 AQSFNLYITPE----YKAKQILNLYIEAWKQGVKT-IYY 748
NrdJ_Z TIGR02504
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ...
 160-748 7.54e-43

ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]


Pssm-ID: 274168 [Multi-domain]  Cd Length: 575  Bit Score: 164.42  E-value: 7.54e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   160 FESMYLGKLKNGR-LESVGQFFLRIAaeaaRGVANNDAFAaavfrdgtRAPDANTVFCLFFMALCRQEIVPPTP-VMLFA 237
Cdd:TIGR02504   2 LAARYLLKDEDGNiIESPEDLFRRVA----RALAAAEDKY--------NSPVWKQWYERFYDLMVNLGFIPNSPtLMNAG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   238 GTESRSYASCFLLDVRgrhtrDVLTSI---AEEIIPVMHSHGGIGL-------YMDCDSNWDDNSSGMMLALKALDSIIA 307
Cdd:TIGR02504  70 GTRLGQLSACFVLPVE-----DSMEDIfeaLKEAALIFKRGGGVGYnfstlrpKGDLVSGTGGVASGPVSFMRVFDSAAG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   308 ASNAVSARPSGLCVYVEPWHRDIMKILRCRgvlAGNEETRCDNTFFALWmpDLFMKRFEANgtwtlfdgraahlsdlyge 387
Cdd:TIGR02504 145 VVKQGGTRRGAQMGILDVWHPDIEEFIEAK---AKEGKLQNFNISVGVT--DEFMEAVEND------------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   388 efeKEYELLERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRaMKCSNLCTEIVHMtDDESvgvC 467
Cdd:TIGR02504 201 ---EEYELRNPRTGEYKEVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGR-INATNPCGEQPLL-PYES---C 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   468 NLTSLNLAAFVTRrnalpGTPPIGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQ 547
Cdd:TIGR02504 273 NLGSINLAKFVKN-----DFGDEASFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKL 347

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   548 GFGLDSVEACRFNGKLFEALALTTFQTSCRIC-ELGmnPFRGFSESKYAKGWLhmdgwPARHLYFDGWDRLRENIKAYGL 626
Cdd:TIGR02504 348 GIPYDSEEARELAEEVMEFIADAAYRASAELAkERG--AFPLYDASKYPMGRA-----MGARIPSALPAEIREAIRKYGI 420

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   627 YNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIQLNVALMETI--ECLYPNKAERRDILErlhknkwsTRG 704
Cdd:TIGR02504 421 RNAQLTTIAPTGTISLIAGTSSGIEPVFALVYFRNVTVGGELLEVNPLVELAlrELGYYSDEIVKYVDE--------KGT 492

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 81987372   705 AFGAALPSQHPlTKFDTAFEADQEHLLRLSADRAPFVDHSQSTT 748
Cdd:TIGR02504 493 VEGAPGPEELP-KVFVTAMDISPEDHVLMQAAIQPWVDSSISKT 535
PRK08447 PRK08447
ribonucleoside-diphosphate reductase subunit alpha;
277-781 4.01e-42

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 236266 [Multi-domain]  Cd Length: 789  Bit Score: 164.90  E-value: 4.01e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  277 GIGLYMDCDSNwddNSSGMMLALKALDSIIAASNAVSARPSGLCVYVEPWHRDIMKILRCRGVlAGNEETRCDNTFFALW 356
Cdd:PRK08447 254 AMGSYIDGHKN---AAGGIIPFLKITNDIAIAVDQLGTRKGAIAVYLEPWHMDISDFIDLRKN-SGEERRRAHDLFPALW 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  357 MPDLFMKRFEANGTWTLFD-GRAAHLSDLYGEEFEKEYELLE-RKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVN 434
Cdd:PRK08447 330 INDLFMKRVEEDAMWTLFDpYECKDLTELYGEEFEKRYLEYEkDEKIIKEYINAKELWKKILTNYFETGLPFLCFKDNAN 409

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  435 RNYFFDMAGrAMKCSNLCTEIVHMT-----------DDESV--------------------------------------- 464
Cdd:PRK08447 410 RANPNAHAG-IIRSSNLCTEIFQNTapnhykikiefEDGSIeffeeeelvtvdsgitkkakkitsldslkgkkiyiveke 488

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  465 ------GVCNLTSLNLAAFVTRRNALPGTPpigtfdyssfrdacaVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQ 538
Cdd:PRK08447 489 kkdgktAVCNLASINLSKINTKEDIERVVP---------------IAIRMLDNVIDLNFYPNRKVKATNLKSRAIGLGVM 553

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  539 GfhTACLLQGFGLD--SVEACRFNGKLFEALALTTFQTSCRIC-ELGMNPfrGFSESKYAKGWLHMDGWP--ARHLYFDG 613
Cdd:PRK08447 554 G--EAQMLAEHKIAwgSKEHLEKIDEIMEQISYNAIDASSNLAlEKGVYP--DFEGSNWSKGIFPIDKANeeAKKLVERG 629

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  614 --------WDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFgnifskitttgediqlnvalmetieclypnk 685
Cdd:PRK08447 630 glfdsacdWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPVY------------------------------- 678

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  686 aerrdilerlhKNKW---STRGAFGAALPSQHPLT-KFDT-AFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEddgavR 760
Cdd:PRK08447 679 -----------KRKWfeeNLSGLIPVVVPNLSPETwQYYTpAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLSLD-----K 742

                        570       580
                 ....*....|....*....|...
gi 81987372  761 AS-RVAH-LLTTAFKYGLKTGMY 781
Cdd:PRK08447 743 ASgKYLNeIYTLAWKLGLKSTYY 765
PRK12364 PRK12364
ribonucleoside-diphosphate reductase subunit alpha;
218-784 3.41e-41

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 237077 [Multi-domain]  Cd Length: 842  Bit Score: 162.61  E-value: 3.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  218 FFMALCRQEIVPPTPVMLFAGTESRSYASCFLLDVRgrhtrDVLTSIAEEI---IPVMHSHGGIGLYMD----CDSN--- 287
Cdd:PRK12364 287 FYDMLSKLKVTMATPTLSNARKPFHQLSSCFIDTVP-----DSLDGIYRSIdnfAQVSKFGGGMGLYFGkvraVGSNirg 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  288 WDDNSSGMMLALKALDSIIAASNAVSARPSGLCVYVEPWHRDIMKILRCRgVLAGNEETRCDNTFFALWMPDLF--MKRF 365
Cdd:PRK12364 362 FQGVAGGVIRWIKLANDTAVAVDQLGMRQGAVAVYLDVWHKDIPEFLQLR-TNNGDDRMKAHDVFPAVCYPDLFwkMVRD 440

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  366 EANGTWTLFD--------GRAahLSDLYGEEFEKEY-ELLERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRN 436
Cdd:PRK12364 441 DINQSWYLFCpheiltvkGYA--LEDYYGEEWEKRYlDCVNDARISKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRA 518

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  437 YffDMAGRAM-KCSNLCTEIV-HMTDDESVG----------------------VCNLTSLNLaafvtrrnalpgtppiGT 492
Cdd:PRK12364 519 N--PNKHKGMiYCSNLCTEIAqNMSAIETVSteietedgdtvvvtttrpgdfvVCNLASLSL----------------GN 580

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  493 FDYSSFRDACAVATVFINALMSLSNL---PIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALAL 569
Cdd:PRK12364 581 IDLEDEEELEEVVRTVVRALDNVIDLnfyPVPYAQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINY 660

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  570 TTFQTSCRIC-ELGMNPFrgFSESKYAKGwlhmdgwparhLYFD-------GWDRLRENIKAYGLYNCQLVALMPTASSS 641
Cdd:PRK12364 661 AAIKASMEIAkEKGAYGY--FEGSDWQTG-----------AYFRkrgytseEWQRLAREVAENGMRNAYLLAVAPTSSTS 727

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  642 QLTEVSEGIHPVFGNIFskitttgediqlnvalmetieclypnkaerrdilerLHKNKwstrgafGAALPSQHPLTKFDT 721
Cdd:PRK12364 728 IIAGTTAGVDPVMKRYF------------------------------------LEEKK-------GALMPRVAPELSDKT 764

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81987372  722 ------AFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEddgaVRASRVAHLLTTAFKYGLKTgMYYCK 784
Cdd:PRK12364 765 fwlyknAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITNE----FTMRQVLDLYLLAWEEGVKT-IYYVR 828
RNR_II_dimer cd02888
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ...
 218-655 7.25e-41

Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.


Pssm-ID: 153089 [Multi-domain]  Cd Length: 464  Bit Score: 156.63  E-value: 7.25e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 218 FFMALCRQEIVPPTPVMLFAGTESR-SYASCFLLDVRGRHTRDVLTSIAEEIIpVMHSHGGIGlymdcdSNW-------- 288
Cdd:cd02888   4 FFYLLLSQGFIPNSPTLMNAGTGELgQLSACFVLPVEDDSIEGIFDALKEAAL-IFKRGGGVG------YNFsrlrpkgd 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 289 -----DDNSSGMMLALKALDSIIAASNAVSARPSGLCVYVEPWHRDIMKILRCRgvlAGNEETRCDNTF-FALWMPDLFM 362
Cdd:cd02888  77 ivkstGGVASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAK---MKEEKTVVLQNFnISVAVTDAFM 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 363 KRFEANGTWTLFdgraaHLSDLYGEEFEKeyellerknvgiaTYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMA 442
Cdd:cd02888 154 EAVENDEPWELR-----NPREPDTGKVYR-------------TVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPGL 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 443 GRaMKCSNLCTEIVHMtDDESvgvCNLTSLNLAAFVTRrnalPGTPPigTFDYSSFRDACAVATVFINALMSLSNLPIKR 522
Cdd:cd02888 216 GR-INATNPCGEQPLL-PYES---CNLGSINLSKFVKN----PFGGA--SFDFERLREAVRLAVRFLDNVIDVNRYPLPE 284

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372 523 ATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRIC-ELGmnPFRGFSESKYAKGWlHM 601
Cdd:cd02888 285 IAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAkERG--PFPLFDASRYLMLK-VI 361

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 81987372 602 DGWParhlyfDGWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFG 655
Cdd:cd02888 362 VNAK------ELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPIFS 409
nrdA PHA02572
ribonucleoside-diphosphate reductase subunit alpha; Provisional
 218-790 8.61e-40

ribonucleoside-diphosphate reductase subunit alpha; Provisional


Pssm-ID: 222883 [Multi-domain]  Cd Length: 753  Bit Score: 157.57  E-value: 8.61e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  218 FFMALCRQEIVPPTPVMLFAGTESRSYASCFLLDvrgrhTRDVLTSI---AEEIIPVMHSHGGIGLymdcdsnwddnSSG 294
Cdd:PHA02572 194 FYNAVSTRKISLPTPIMAGVRTPTRQFSSCVVIE-----SGDSLDSInktAMAIVKYISKRAGIGI-----------NAG 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  295 MMLA------------------LKALDSIIAASNAVSARPSGLCVYVEPWHRDIMKILrcrgVLAGN---EETRCDNTFF 353
Cdd:PHA02572 258 MIRAegskirggevrhtgvipfWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLL----VLKNNkgvEENRIRHLDY 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  354 ALWMPDLFMKRFEANGTWTLFDGRAAH--LSDLYG---EEFEKEYELLER-KNVGIATYPARDVMFALIKSAVSTGTPFV 427
Cdd:PHA02572 334 GVQINDLMYERFIKNDYITLFSPHDVGgeLYDAYFadqDRFRELYEALEKdPSVRKKRIKAQELFLLLLKERSETGRIYI 413

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  428 MFKHAVNrNY--FFDmagrAMKCSNLCTEIV-------HMTDDESVGVCNLTSLNLAAFVtrrnalpgtppigtfDYSSF 498
Cdd:PHA02572 414 MFIDHCN-NHspFKD----PIRQSNLCCEIAlptkplnHIDGEGEIALCTLSAIVLGNFE---------------DQDEI 473

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  499 RDACAVATVFINALMSLSNLPIKRATTGNERlRSIGIGVQGFHTACLLQGFGLDSVEAcRFNGKLFEALALTTFQTSCRI 578
Cdd:PHA02572 474 EELAEVAVRALDNLLDYQDYPVPAALKAKKR-RSLGVGVTNYAHYLAKNFASYEDANA-DLVHELFERLQYYLIKASNKL 551

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  579 C-ELGMNPFrgFSESKYAKGWLHMDGWP------ARHLYFDGWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIH 651
Cdd:PHA02572 552 AkEKGACEY--FSDTKYSRGELPIDWYKkkvdelVAPKYNCDWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIE 629

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  652 PvfgnifskitttgediqlnvalmetieclyPnkaerRDILERlhknKWSTRGAFGAALPSQHPLTKFDT----AFEADQ 727
Cdd:PHA02572 630 P------------------------------P-----RGPVSI----KKSKEGPFNQVVPNVETLKDLYDllwdLAKKGN 670

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81987372  728 EHLLRLSADRAPFVDHSQSTTLYVVEE--DDGAVRASRVAHLLTTAFKYGLKTgMYYCKVRKATD 790
Cdd:PHA02572 671 KGYLTQVAIMQKFVDQAISANTSYDPEnyPNGKVPMSVMLDDLLYFYYYGGKT-LYYHNTRDGKG 734
PRK09102 PRK09102
ribonucleoside-diphosphate reductase subunit alpha;
168-811 1.39e-39

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 236378 [Multi-domain]  Cd Length: 601  Bit Score: 155.50  E-value: 1.39e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  168 LKNGRL---ESVGQFFLRIAAEAARGvanNDAFAAAVFRDGTRapdantvfcLFFMalcrqeivPPTPVMLFAGTESRSY 244
Cdd:PRK09102  29 LRDRYLlegESYQDLFARIAEAYADI---DPEHAQRFYDYMSR---------GWFM--------PATPVLSNGGTDRGLP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  245 ASCFLldvrgRHTRDVLTSI----AEEIIpvMHSHGG-IGLYmdcdsnWDD------------NSSGMMLALKALDSIIA 307
Cdd:PRK09102  89 ISCFL-----NYVEDSLEGIvntwNENVW--LAKRGGgIGSY------WGNvrsigepirnngKSSGIIPFIKVMDSLTL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  308 ASNAVSARPSGLCVYVEPWHRDIMKILRCRgVLAGNEETRCDNTFFALWMPDLFMKRFEANGTWTLFDgraahlsdlyge 387
Cdd:PRK09102 156 AISQGSLRRGSFAVYLDIEHPEIEEFLDIR-KPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLIS------------ 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  388 efekeyellERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNY--FFDMAGRAMKCSNLCTEIV------HMT 459
Cdd:PRK09102 223 ---------PKDKSVIRTVKARDLWAKILETRIETGEPYLLFIDNVNRALpeVYKDLGLKVKASNLCSEITlptgidHLG 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  460 DDESVgVCNLTSLNLAAFVTRRNAlpgtpPIGTFDYSSFRDAcaVATVFINalmslsNLP--IKRATTGNERLRSIGIGV 537
Cdd:PRK09102 294 EDRTA-VCCLSSLNLEYYDEWKDT-----DAFIEDLMRFLDN--VLQDFID------KAPdeMERAKYSAMRERSVGLGV 359

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  538 QGFHTacLLQGFGL--DSVEACRFNGKLFEALALTTFQTSCRICELgmnpfRGfsESKYAKGWlhmdGWPARhlyfdgwd 615
Cdd:PRK09102 360 MGFHS--YLQSKMIpfESVMAKQWNKKIFKHIREQADKASKELAKE-----KG--ECPDAAGY----GVMRR-------- 418

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  616 rlrenikayglyNCQLVALMPTASSSQ-LTEVSEGIHPVFGNIFSKITTTGEDIQLNVALMET-IECLYPNKAERRDILE 693
Cdd:PRK09102 419 ------------FSTKMAIAPTASISIiLGNTSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLlEEKGKDTDEVWSSILT 486

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  694 rlhkNKWSTrgafgaalpsQH--PLTK-----FDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVveedDGAVRASRVAH 766
Cdd:PRK09102 487 ----NEGSV----------QHldFLSEeekdvFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFL----PANVPKRDLNK 548

                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....
gi 81987372  767 LLTTAFKYGLKTgMYYCK---VRKATDNGVFLGTDTC------RRDDPTCLACQ 811
Cdd:PRK09102 549 LHFEAWKKGVKS-LYYQRsksVQRADKVSHDVLKKRLveksafNRDYDECLACQ 601
PRK09103 PRK09103
ribonucleoside-diphosphate reductase subunit alpha;
218-657 3.15e-22

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 181649 [Multi-domain]  Cd Length: 758  Bit Score: 102.37  E-value: 3.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  218 FFMALCRQEIVPPTPVMLFAGTESRSYASCFLLDvrgrhTRDVLTSI---AEEIIPVMHSHGGIGLymdcdsnwddnSSG 294
Cdd:PRK09103 193 FYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIE-----CGDSLDSInatSSAIVKYVSQRAGIGI-----------NAG 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  295 mmlALKALDSII------------------AASNAVS---ARPSGLCVYVEPWHRDIMKILrcrgVLAGN---EETRCDN 350
Cdd:PRK09103 257 ---RIRALGSPIrggeafhtgcipfykhfqTAVKSCSqggVRGGAATLFYPIWHLEVESLL----VLKNNrgvEENRVRH 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  351 TFFALWMPDLFMKRFEANGTWTLFDgrAAHLSDLYG------EEFEKEYELLER-KNVGIATYPARDVMFALIKSAVSTG 423
Cdd:PRK09103 330 MDYGVQINKLMYQRLIKGGDITLFS--PSDVPGLYDaffadqDEFERLYTKYEQdDSIRKKRVKAVELFSLMMQERASTG 407

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  424 TPFVMFKHAVNRNYFFDMAGRAMKCSNLCTEIVHMT------DDES--VGVCNLTSLNLAAfvtrrnalpgtppIGTFDy 495
Cdd:PRK09103 408 RIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIALPTkplndvNDENgeIALCTLSAFNLGA-------------INSLD- 473

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  496 sSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTS 575
Cdd:PRK09103 474 -ELEELADLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEAIQYYLLKAS 552

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  576 CRIC-ELGMNPFrgFSESKYAKGWL-------HMDGWPARHLYFDgWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVS 647
Cdd:PRK09103 553 NELAkEQGACPW--FNETTYAQGILpidtykkDLDAICNEPLHYD-WETLREEIKTHGLRNSTLSALMPSETSSQISNAT 629

                        490
                 ....*....|
gi 81987372  648 EGIHPVFGNI 657
Cdd:PRK09103 630 NGIEPPRGYV 639
PRK08332 PRK08332
vitamin B12-dependent ribonucleotide reductase;
467-666 1.61e-19

vitamin B12-dependent ribonucleotide reductase;


Pssm-ID: 181392 [Multi-domain]  Cd Length: 1740  Bit Score: 94.45  E-value: 1.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   467 CNLTSLNLAAFVTRRNAlpGTPpigTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLL 546
Cdd:PRK08332 1308 CNLASINLAKFVKYDEN--GKP---YFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFK 1382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   547 QGFGLDSVEACRFNGKLFEALALTTFQTSCRICElGMNPFRGFSESKYAKGWLHMDGWPARHLYFDGWDRLRENIKAYGL 626
Cdd:PRK08332 1383 LGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAK-KRGTFPLYEKTEYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGV 1461

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 81987372   627 YNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGE 666
Cdd:PRK08332 1462 RNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGE 1501
Ribonuc_red_lgN pfam00317
Ribonucleotide reductase, all-alpha domain;
153-240 2.20e-12

Ribonucleotide reductase, all-alpha domain;


Pssm-ID: 459758 [Multi-domain]  Cd Length: 75  Bit Score: 63.03  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   153 GLQSARKFESMYLGKLKNGR-LESVGQFFLRIAAEAARGVANNDAFAAAVfrdgtrapdantvfcLFFMALCRQEIVPPT 231
Cdd:pfam00317   2 TYLGAKVLEDRYLLKDEDGElLETPQDMFMRVALALAGAELEEDRLELAE---------------EFYDLLSSLKFLPAT 66


                  ....*....
gi 81987372   232 PVMLFAGTE 240
Cdd:pfam00317  67 PTLMNAGTP 75
PRK06406 PRK06406
vitamin B12-dependent ribonucleotide reductase;
408-691 1.96e-11

vitamin B12-dependent ribonucleotide reductase;


Pssm-ID: 235796 [Multi-domain]  Cd Length: 771  Bit Score: 67.57  E-value: 1.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  408 ARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRaMKCSNLCTEIVHMTDdESvgvCNLTSLNLAAFVTRrnalpgt 487
Cdd:PRK06406 393 ARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKNLGE-IESTNPCGEQPLLPY-ES---CNLGSINLSKFVEN------- 460

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  488 ppiGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEAL 567
Cdd:PRK06406 461 ---GKIDWDRLRETVHIATRFLDNVIDANKFPVPQIKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFI 537

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  568 ALTTFQTSCRICELgmnpfRGFSESKYAKGWlhmdgWparhlyfdgwdrlRENIKaygLYNCQLVALMPTASSSQLTEVS 647
Cdd:PRK06406 538 NEESHRASQKLAEE-----RGVFPAWYGSEW-----E-------------KKGIK---MRNSTTTTIAPTGTISIIAGCS 591

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 81987372  648 EGIHPVFGNIFSKITTTGEDiqlnvaLMEtIECLYPNKAERRDI 691
Cdd:PRK06406 592 SSIEPLFAIAFVRHVLNGQE------LLE-VNPLFEEITRKRGL 628
PRK08665 PRK08665
vitamin B12-dependent ribonucleotide reductase;
164-654 7.91e-11

vitamin B12-dependent ribonucleotide reductase;


Pssm-ID: 236330 [Multi-domain]  Cd Length: 752  Bit Score: 65.73  E-value: 7.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  164 YLGKLKNGR-LESVGQFFLRIAaeaargvannDAFAAAVFRDGTRApDANTVFCLFFMALCRQEIVPPTPVMLFAGTESR 242
Cdd:PRK08665  24 YLKKDEDGKpIETPEDMFRRVA----------RTIAAAELIYDSKA-DVEALADRFYDLMTSLEFLPNSPTLMNAGRELG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  243 SYASCFLLDVRgrhtrDVLTSIAEEI--IPVMH-SHGGIGLYMdcdSNwddnssgmmlaLKALDSIIAASNAVSARP-SG 318
Cdd:PRK08665  93 QLSACFVLPVG-----DSIEEIFDAVkhAALIHkSGGGTGFSF---SR-----------LRPKNDRVGSTGGVASGPvSF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  319 LCVY----------------------VEpwHRDIMKILRCRgvlagNEETRCDNTFFALWMPDLFMKRFEANGtwtlfdg 376
Cdd:PRK08665 154 MRVFdaateaikqggtrrganmgilrVD--HPDIMEFITCK-----EDNGELTNFNISVAITEAFMEAVEADE------- 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  377 raahlsdlygeefekEYELLERKNVGIA-TYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRaMKCSNLCTEi 455
Cdd:PRK08665 220 ---------------EYDLINPRTGEVVgRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGE-IESTNPCGE- 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  456 VHMTDDESvgvCNLTSLNLAAFVTRrnalpgtppiGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGI 535
Cdd:PRK08665 283 QPLLPYES---CNLGSINLSKMVKN----------GDVDWEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGL 349

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  536 GVQGFHTACLLQGFGLDSVEACRFNGKLF-----------EALALttfqtscricELGmnPFRGFSESKYAKgwlhmdgw 604
Cdd:PRK08665 350 GVMGWADMLIQLGIPYDSEEAVELAEKVMkfiqdeahaasRELAE----------ERG--PFPNYEGSIYDK-------- 409

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 81987372  605 parhlyfDGWDRLRenikayglyNCQLVALMPTASSSQLTEVSEGIHPVF 654
Cdd:PRK08665 410 -------DGLGPMR---------NATVTTIAPTGTISIIAGCSSGIEPLF 443
PRK08115 PRK08115
vitamin B12-dependent ribonucleotide reductase;
466-654 9.46e-11

vitamin B12-dependent ribonucleotide reductase;


Pssm-ID: 236152 [Multi-domain]  Cd Length: 858  Bit Score: 65.63  E-value: 9.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  466 VCNLTSLNLAAFVTRRNalpgtppiGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACL 545
Cdd:PRK08115 489 VCNLAAINLANMADKET--------KTVDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRVGLGVMGLHDLLI 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  546 LQGFGLDSVEACRFNGKLFEALALTTFQTSCRIC-ELGMNPF-------------RGFSESKYakgwlhMDGWPARhlyf 611
Cdd:PRK08115 561 YCETVYGSEEGNQLVDQIFETIATTAYRTSIELAkEKGSFPFlvgqteeetaklrEAFINTGY------MKKMPED---- 630

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 81987372  612 dgwdrLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVF 654
Cdd:PRK08115 631 -----IREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPYF 668
PRK06556 PRK06556
vitamin B12-dependent ribonucleotide reductase; Validated
 359-593 2.32e-08

vitamin B12-dependent ribonucleotide reductase; Validated


Pssm-ID: 235828 [Multi-domain]  Cd Length: 953  Bit Score: 58.06  E-value: 2.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  359 DLFMKRFEANGTWTL---FDGRAahlsdlygeefekeyellerknvgIATYPARDVMFALIKSAVSTGTPFVMFKHAVNR 435
Cdd:PRK06556 287 DEFMRAVENDGEFGLrarTDGEV------------------------IETVDAKELFRKIAEAAWECADPGIQYDDTIND 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  436 NYFFDMAGRaMKCSNLCTEIVHMtDDESvgvCNLTSLNLAAFVTrrnalpgtpPIGTFDYSSFRDACAVATVFINALMSL 515
Cdd:PRK06556 343 WHTCPESGR-INASNPCSEYMFL-DNSS---CNLASLNLMKFLR---------DDGTFDVESFRHAVELVITAMEISICF 408

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81987372  516 SNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRICELgMNPFRGFSESK 593
Cdd:PRK06556 409 ADFPTEKIARNTRAFRQLGLGYANLGALLMATGLPYDSDGGRALAAAITSLMTGEAYRRSAELAGV-VGPFEGYARNA 485
PRK06948 PRK06948
ribonucleotide reductase-like protein; Provisional
 404-777 1.80e-07

ribonucleotide reductase-like protein; Provisional


Pssm-ID: 180772 [Multi-domain]  Cd Length: 595  Bit Score: 54.80  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  404 ATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYffDMAGR-AMKCSNLCTEivhmTDDESVGVCNLTSLNLAAFVTRRN 482
Cdd:PRK06948 244 ATVPARHLWREIVSAARDSAEPGLLFVDTIDAAN--PLREHeRIDATNPCGE----QPLPPYGSCVLGPIDLSRFVRHPF 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  483 ALPGTPpigTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGK 562
Cdd:PRK06948 318 GVGGEP---RFDFAALATAVRIQVRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARY 394

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  563 LFEALALTTFQTSCRI-CELGmnPFRGFSESKYAKGWLHMDGWPARhlyfdgwdrLRENIKAYGLYNCQLVALMPTASSS 641
Cdd:PRK06948 395 IASDLRHHAYAASAALaAERG--AYPLCDPAAHLDALRAGPPLPHA---------VCHAIARHGLRNSHLLSFAPVGSVS 463

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372  642 QL--TEVSEGIHPVFGNIFSKITTTGEDiqlNVALMETieclyPNKAERrdILERLHKNKwstrgafgAALPSQhpltkF 719
Cdd:PRK06948 464 LAfgDNCSPGIEPARAWIEHRPVRAGAG---GARGMRA-----ENHAYR--LFRSLRGER--------AALPDY-----F 520

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 81987372  720 DTAFEADQEHLLRLSADRAPFVDHSQSTTLYVveedDGAVRASRVAHLLTTAFKYGLK 777
Cdd:PRK06948 521 VTAADVAPADHLAMRAALQPYVDAGISKTVTL----PNHYSLAEVDALLFQAWRAGLK 574
PRK07562 PRK07562
vitamin B12-dependent ribonucleotide reductase;
357-601 1.78e-03

vitamin B12-dependent ribonucleotide reductase;


Pssm-ID: 236049 [Multi-domain]  Cd Length: 1220  Bit Score: 41.87  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   357 MPDLFMKRFEANGTWtlfdgraahlsdlygeefekeyELLERKNVGIA-TYPARD----VMFALIKSAvstgTPFVMFKH 431
Cdd:PRK07562  403 VTDEFLRAVENDGDW----------------------NLTARTDGKVAkTLKARDlwekIGYAAWASA----DPGLQFNT 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   432 AVNRNYFFDMAGRaMKCSNLCTEivHMTDDESVgvCNLTSLNLAAFVTRRNalpgtppiGTFDYSSFRDACAVATVF--I 509
Cdd:PRK07562  457 TINDWHTCPASGP-IRASNPCSE--YMFLDDTA--CNLASLNLLTFRDEDT--------KRFDVEAYEHACRLWTVVleI 523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987372   510 NALMslSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRIC-ELGmnPFRG 588
Cdd:PRK07562  524 SVLM--AQFPSKEIAELSYEFRTLGLGYANIGGLLMTMGIPYDSDEGRAICGALSAIMTGVAYATSAEMAkELG--PFPG 599

                         250
                  ....*....|...
gi 81987372   589 fseskYAKGWLHM 601
Cdd:PRK07562  600 -----YEKNADHM 607
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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