|
Name |
Accession |
Description |
Interval |
E-value |
| UCH |
pfam00443 |
Ubiquitin carboxyl-terminal hydrolase; |
44-334 |
3.95e-68 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 425685 [Multi-domain] Cd Length: 310 Bit Score: 215.77 E-value: 3.95e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 44 TGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKfllPSDCSEVATAFAYLMTDMWLGDSD-CVSPEIFWSALG 122
Cdd:pfam00443 1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSR---YNKDINLLCALRDLFKALQKNSKSsSVSPKMFKKSLG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 123 NLYPAFTKKMQQDAQEFLICVLNELHEALKKYHysrrrsyekgstqrccrkwITTETSIITQLFEEQLNYSIVCLKCEKC 202
Cdd:pfam00443 78 KLNPDFSGYKQQDAQEFLLFLLDGLHEDLNGNH-------------------STENESLITDLFRGQLKSRLKCLSCGEV 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 203 TYKNEVFTVFSLPIPSK----YECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQG 278
Cdd:pfam00443 139 SETFEPFSDLSLPIPGDsaelKTASLQICFLQFSKLEELDDEEKYYCDKCGCKQDAIKQLKISRLPPVLIIHLKRFSYNR 218
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 279 TTKRKLRTDIHYPLTnLDLTPYICSIFRKY----PKYNLCAVVNHFGDLDGGHYTAFCKN 334
Cdd:pfam00443 219 STWEKLNTEVEFPLE-LDLSRYLAEELKPKtnnlQDYRLVAVVVHSGSLSSGHYIAYIKA 277
|
|
| Peptidase_C19R |
cd02674 |
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-338 |
2.16e-63 |
|
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239139 [Multi-domain] Cd Length: 230 Bit Score: 200.98 E-value: 2.16e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLCSilplveyfltgkyitalqkfllpsdcsevatafaylmtdmwlgdsdcvspeifwsalgnl 124
Cdd:cd02674 1 GLRNLGNTCYMNSILQCLSA------------------------------------------------------------ 20
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 125 ypaftkkMQQDAQEFLICVLNELHealkkyhysrrrsyekgstqrccrkwittetSIITQLFEEQLNYSIVCLKCEKCTY 204
Cdd:cd02674 21 -------DQQDAQEFLLFLLDGLH-------------------------------SIIVDLFQGQLKSRLTCLTCGKTST 62
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 205 KNEVFTVFSLPIPSKY----ECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTT 280
Cdd:cd02674 63 TFEPFTYLSLPIPSGSgdapKVTLEDCLRLFTKEETLDGDNAWKCPKCKKKRKATKKLTISRLPKVLIIHLKRFSFSRGS 142
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 74723115 281 KRKLRTDIHYPLTNLDLTPY-ICSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCKNSVTQ 338
Cdd:cd02674 143 TRKLTTPVTFPLNDLDLTPYvDTRSFTGPFKYDLYAVVNHYGSLNGGHYTAYCKNNETN 201
|
|
| Peptidase_C19 |
cd02257 |
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ... |
45-338 |
1.11e-46 |
|
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239072 [Multi-domain] Cd Length: 255 Bit Score: 158.80 E-value: 1.11e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLCSilplveyfltgkyitalqkfllpsdcsevatafaylmtdmwlgdsdcvspeifwsalgnl 124
Cdd:cd02257 1 GLNNLGNTCYLNSVLQALFS------------------------------------------------------------ 20
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 125 ypaftkkMQQDAQEFLICVLNELHEALKKYHYSRrrsyekgstqrccrKWITTETSIITQLFEEQLNYSIVCLKCEKCTY 204
Cdd:cd02257 21 -------EQQDAHEFLLFLLDKLHEELKKSSKRT--------------SDSSSLKSLIHDLFGGKLESTIVCLECGHESV 79
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 205 KNEVFTVFSLPIP--SKYECSLRDCLQCFFQQDALTWNNEIHCSfCETKQETAVRASISKAPKIIIFHLKRFDIQGT-TK 281
Cdd:cd02257 80 STEPELFLSLPLPvkGLPQVSLEDCLEKFFKEEILEGDNCYKCE-KKKKQEATKRLKIKKLPPVLIIHLKRFSFNEDgTK 158
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74723115 282 RKLRTDIHYPLTnLDLTPYICSIFRKYP------KYNLCAVVNHFGDL-DGGHYTAFCKNSVTQ 338
Cdd:cd02257 159 EKLNTKVSFPLE-LDLSPYLSEGEKDSDsdngsyKYELVAVVVHSGTSaDSGHYVAYVKDPSDG 221
|
|
| Peptidase_C19E |
cd02661 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
44-335 |
4.07e-36 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239126 [Multi-domain] Cd Length: 304 Bit Score: 132.40 E-value: 4.07e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 44 TGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKY-----------ITALQKFllpsdcseVATAFAylmtdmwlGDSDCV 112
Cdd:cd02661 2 AGLQNLGNTCFLNSVLQCLTHTPPLANYLLSREHskdccnegfcmMCALEAH--------VERALA--------SSGPGS 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 113 SPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEAlkkyhYSRRRSYEKGSTQRccrkwiTTETSIITQLFEEQLNY 192
Cdd:cd02661 66 APRIFSSNLKQISKHFRIGRQEDAHEFLRYLLDAMQKA-----CLDRFKKLKAVDPS------SQETTLVQQIFGGYLRS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 193 SIVCLKCEKCTYKNEVFTVFSLPIPSkyECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLK 272
Cdd:cd02661 135 QVKCLNCKHVSNTYDPFLDLSLDIKG--ADSLEDALEQFTKPEQLDGENKYKCERCKKKVKASKQLTIHRAPNVLTIHLK 212
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74723115 273 RFdiQGTTKRKLRTDIHYPLTnLDLTPYICSIFRKYPKYNLCAVVNHFG-DLDGGHYTAFCKNS 335
Cdd:cd02661 213 RF--SNFRGGKINKQISFPET-LDLSPYMSQPNDGPLKYKLYAVLVHSGfSPHSGHYYCYVKSS 273
|
|
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-333 |
7.87e-36 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 131.66 E-value: 7.87e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLcsilplveYFLTgkYITALqkfllpsdcsevATAFAYLMTDMWLGDSdcVSPEIFWSALGNL 124
Cdd:cd02663 1 GLENFGNTCYCNSVLQAL--------YFEN--LLTCL------------KDLFESISEQKKRTGV--ISPKKFITRLKRE 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 125 YPAFTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSYEKGSTQRCcrkwiTTETSIITQLFEEQLNYSIVCLKCEKCTY 204
Cdd:cd02663 57 NELFDNYMHQDAHEFLNFLLNEIAEILDAERKAEKANRKLNNNNNA-----EPQPTWVHEIFQGILTNETRCLTCETVSS 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 205 KNEVFTVFSLPIPSkyECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTTKR-- 282
Cdd:cd02663 132 RDETFLDLSIDVEQ--NTSITSCLRQFSATETLCGRNKFYCDECCSLQEAEKRMKIKKLPKILALHLKRFKYDEQLNRyi 209
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 74723115 283 KLRTDIHYPLTnldLTPYICSIFRKYP--KYNLCAVVNHFGdlDG---GHYTAFCK 333
Cdd:cd02663 210 KLFYRVVFPLE---LRLFNTTDDAENPdrLYELVAVVVHIG--GGpnhGHYVSIVK 260
|
|
| Peptidase_C19D |
cd02660 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-338 |
5.46e-35 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239125 [Multi-domain] Cd Length: 328 Bit Score: 130.19 E-value: 5.46e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYiTALQKFLLPSDC--SEVATAFAYLMTdmwlgdSDCVSPEIF----- 117
Cdd:cd02660 2 GLINLGATCFMNVILQALLHNPLLRNYFLSDRH-SCTCLSCSPNSClsCAMDEIFQEFYY------SGDRSPYGPinlly 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 118 --WSALGNLypAFTKkmQQDAQEFLICVLNELHEALKkyhysrRRSYEKGSTQRCcrkwitteTSIITQLFEEQLNYSIV 195
Cdd:cd02660 75 lsWKHSRNL--AGYS--QQDAHEFFQFLLDQLHTHYG------GDKNEANDESHC--------NCIIHQTFSGSLQSSVT 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 196 CLKCEKCTYKNEVFTVFSLPIPSKYECS-------------LRDCLQCFFQQDALTwNNEIHCSFCETKQETAVRASISK 262
Cdd:cd02660 137 CQRCGGVSTTVDPFLDLSLDIPNKSTPSwalgesgvsgtptLSDCLDRFTRPEKLG-DFAYKCSGCGSTQEATKQLSIKK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 263 APKIIIFHLKRFD-IQGTTKRKLRTDIHYPLTnLDLTPYICSIFRKYP---------KYNLCAVVNHFGDLDGGHYTAFC 332
Cdd:cd02660 216 LPPVLCFQLKRFEhSLNKTSRKIDTYVQFPLE-LNMTPYTSSSIGDTQdsnsldpdyTYDLFAVVVHKGTLDTGHYTAYC 294
|
....*.
gi 74723115 333 KNSVTQ 338
Cdd:cd02660 295 RQGDGQ 300
|
|
| Peptidase_C19K |
cd02667 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-333 |
6.02e-28 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239132 [Multi-domain] Cd Length: 279 Bit Score: 109.78 E-value: 6.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTgkyitalqkfllpsdcsevatafaylmtdmwlgdsdcvSPEIFWSALGNL 124
Cdd:cd02667 1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE--------------------------------------TPKELFSQVCRK 42
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 125 YPAFTKKMQQDAQEFLICVLNELhealkkyhysrrrsyekgstqrccrkwitteTSIITQLFEEQLNYSIVCLKCEKCTY 204
Cdd:cd02667 43 APQFKGYQQQDSHELLRYLLDGL-------------------------------RTFIDSIFGGELTSTIMCESCGTVSL 91
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 205 KNEVFTVFSLPI--PSKYECSLRDCLQCFFQQDALTWNNEIHCSFCetkQETAVRASISKAPKIIIFHLKRFdiQGTTK- 281
Cdd:cd02667 92 VYEPFLDLSLPRsdEIKSECSIESCLKQFTEVEILEGNNKFACENC---TKAKKQYLISKLPPVLVIHLKRF--QQPRSa 166
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 74723115 282 --RKLRTDIHYPLTnLDLTPYI---CSIFR--KYPKYNLCAVVNHFGDLDGGHYTAFCK 333
Cdd:cd02667 167 nlRKVSRHVSFPEI-LDLAPFCdpkCNSSEdkSSVLYRLYGVVEHSGTMRSGHYVAYVK 224
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-337 |
2.56e-26 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 106.35 E-value: 2.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDC----SEVATAFAYLMTDMWLGDSDCVSPEIFWSA 120
Cdd:cd02668 1 GLKNLGATCYVNSFLQLWFMNLEFRKAVYECNSTEDAELKNMPPDKphepQTIIDQLQLIFAQLQFGNRSVVDPSGFVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 121 LGnlypaFTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSyekgstqrccrkwittetsIITQLFEEQLNYSIVCLKCE 200
Cdd:cd02668 81 LG-----LDTGQQQDAQEFSKLFLSLLEAKLSKSKNPDLKN-------------------IVQDLFRGEYSYVTQCSKCG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 201 KCTYKNEVFtvFSLPIPSKYECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKR--FDIQG 278
Cdd:cd02668 137 RESSLPSKF--YELELQLKGHKTLEECIDEFLKEEQLTGDNQYFCESCNSKTDATRRIRLTTLPPTLNFQLLRfvFDRKT 214
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 279 TTKRKLRTDIHYPLTnLDLTPYICSIFRKYPKYNLCAVVNHFG-DLDGGHYTAFCKNSVT 337
Cdd:cd02668 215 GAKKKLNASISFPEI-LDMGEYLAESDEGSYVYELSGVLIHQGvSAYSGHYIAHIKDEQT 273
|
|
| peptidase_C19C |
cd02659 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-333 |
3.23e-26 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239124 [Multi-domain] Cd Length: 334 Bit Score: 106.57 E-value: 3.23e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLcsilplveYFLTG--KYITALQKFLLPSDCSEVATAFAYLMTDMWLGDSDCVSPEIFWSALG 122
Cdd:cd02659 4 GLKNQGATCYMNSLLQQL--------YMTPEfrNAVYSIPPTEDDDDNKSVPLALQRLFLFLQLSESPVKTTELTDKTRS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 123 NLYPAFTKKMQQDAQEFLICVLNELHEALKKyhysrrrsyekgstqrccrkwiTTETSIITQLFEEQLNYSIVCLKCEKC 202
Cdd:cd02659 76 FGWDSLNTFEQHDVQEFFRVLFDKLEEKLKG----------------------TGQEGLIKNLFGGKLVNYIICKECPHE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 203 TYKNEVFTVFSLPIPSKYecSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRF--DIQGTT 280
Cdd:cd02659 134 SEREEYFLDLQVAVKGKK--NLEESLDAYVQGETLEGDNKYFCEKCGKKVDAEKGVCFKKLPPVLTLQLKRFefDFETMM 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74723115 281 KRKLRTDIHYPLTnLDLTPYI-----------CSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCK 333
Cdd:cd02659 212 RIKINDRFEFPLE-LDMEPYTekglakkegdsEKKDSESYIYELHGVLVHSGDAHGGHYYSYIK 274
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
42-219 |
1.17e-23 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 101.88 E-value: 1.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 42 GVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAFAYLMTDMWLGDSDCVSPEIFWSAL 121
Cdd:COG5560 264 GTCGLRNLGNTCYMNSALQCLMHTWELRDYFLSDEYEESINEENPLGMHGSVASAYADLIKQLYDGNLHAFTPSGFKKTI 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 122 GNLYPAFTKKMQQDAQEFLICVLNELHEAL----KKYHYSRRRSYE------KGSTQRCCRKWITTETSIITQLFEEQLN 191
Cdd:COG5560 344 GSFNEEFSGYDQQDSQEFIAFLLDGLHEDLnriiKKPYTSKPDLSPgddvvvKKKAKECWWEHLKRNDSIITDLFQGMYK 423
|
170 180
....*....|....*....|....*...
gi 74723115 192 YSIVCLKCEKCTYKNEVFTVFSLPIPSK 219
Cdd:COG5560 424 STLTCPGCGSVSITFDPFMDLTLPLPVS 451
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
173-338 |
1.84e-21 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 95.34 E-value: 1.84e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 173 KWITTETSIITQLF-----EEQLNYS----IVCLKCEKCTykNEVFTVFSLPIPSKYEC-----SLRDCLQCFFQQDALT 238
Cdd:COG5560 614 SWLKLETEIDTKREeqveeEGQMNFNdavvISCEWEEKRY--LSLFSYDPLWTIREIGAaertiTLQDCLNEFSKPEQLG 691
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 239 WNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTTKRKLRTDIHYPLTNLDLTPYICSIFRKYPKYNLCAVVN 318
Cdd:COG5560 692 LSDSWYCPGCKEFRQASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYPIDDLDLSGVEYMVDDPRLIYDLYAVDN 771
|
170 180
....*....|....*....|
gi 74723115 319 HFGDLDGGHYTAFCKNSVTQ 338
Cdd:COG5560 772 HYGGLSGGHYTAYARNFANN 791
|
|
| Peptidase_C19B |
cd02658 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-333 |
5.03e-20 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239123 [Multi-domain] Cd Length: 311 Bit Score: 88.92 E-value: 5.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKfLLPSDC-----SEVATAF-----AYLMTDMWLGDS--DCV 112
Cdd:cd02658 1 GLRNLGNSCYLNSVLQVLFSIPSFQWRYDDLENKFPSDV-VDPANDlncqlIKLADGLlsgrySKPASLKSENDPyqVGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 113 SPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKyhysrrrsyekgstqrccrkwitTETSIITQLFEEQLNY 192
Cdd:cd02658 80 KPSMFKALIGKGHPEFSTMRQQDALEFLLHLIDKLDRESFK-----------------------NLGLNPNDLFKFMIED 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 193 SIVCLKCEKCTYKNEVFTVFSLPIP------------SKYECSLRDCLQCFFQQDALtwnnEIHCSFCETKQETAVRASI 260
Cdd:cd02658 137 RLECLSCKKVKYTSELSEILSLPVPkdeatekeegelVYEPVPLEDCLKAYFAPETI----EDFCSTCKEKTTATKTTGF 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74723115 261 SKAPKIIIFHLKRFDI-QGTTKRKLRTDIHYPltnLDLTPyicsifrkyPKYNLCAVVNHFG-DLDGGHYTAFCK 333
Cdd:cd02658 213 KTFPDYLVINMKRFQLlENWVPKKLDVPIDVP---EELGP---------GKYELIAFISHKGtSVHSGHYVAHIK 275
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-335 |
5.09e-20 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 88.54 E-value: 5.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTgkYITALQKFLLPSDcsEVATAFAYLMTDMwLGDSDCVSPEIFWSALGNL 124
Cdd:cd02657 1 GLTNLGNTCYLNSTLQCLRSVPELRDALKN--YNPARRGANQSSD--NLTNALRDLFDTM-DKKQEPVPPIEFLQLLRMA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 125 YPAFTKK------MQQDAQEFLICVLNELhealkkyhysrRRSYEKGStqrccrkwitTETSIITQLFEEQLNYSIVCLK 198
Cdd:cd02657 76 FPQFAEKqnqggyAQQDAEECWSQLLSVL-----------SQKLPGAG----------SKGSFIDQLFGIELETKMKCTE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 199 CEKC-TYKNEVFTVFSLPIPSKYECS-LRDCLqcffqQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRF-- 274
Cdd:cd02657 135 SPDEeEVSTESEYKLQCHISITTEVNyLQDGL-----KKGLEEEIEKHSPTLGRDAIYTKTSRISRLPKYLTVQFVRFfw 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74723115 275 --DIQgtTKRKLRTDIHYPLtNLDLTPYiCSifrKYPKYNLCAVVNHFG-DLDGGHYTAFCKNS 335
Cdd:cd02657 210 krDIQ--KKAKILRKVKFPF-ELDLYEL-CT---PSGYYELVAVITHQGrSADSGHYVAWVRRK 266
|
|
| Peptidase_C19O |
cd02671 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-333 |
1.07e-17 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239136 [Multi-domain] Cd Length: 332 Bit Score: 82.63 E-value: 1.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLCsilpLVEYFLTGkyitalQKFLLPSDCS-EVATAFAYLMTDMWLGDSDCVSPEIFWSALGN 123
Cdd:cd02671 26 GLNNLGNTCYLNSVLQVLY----FCPGFKHG------LKHLVSLISSvEQLQSSFLLNPEKYNDELANQAPRRLLNALRE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 124 LYPAFTKKMQQDAQEFLICVLNELHEALKKyhysrrrsyekgstqrccrkwittetsiitqLFEEQLNYSIVCLKCEKCT 203
Cdd:cd02671 96 VNPMYEGYLQHDAQEVLQCILGNIQELVEK-------------------------------DFQGQLVLRTRCLECETFT 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 204 YKNEVFTVFSLPIPS----------------KYECS-LRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKI 266
Cdd:cd02671 145 ERREDFQDISVPVQEselskseesseispdpKTEMKtLKWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKLPEV 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74723115 267 IIFHLKRFDIQGTTK------RKLRTdihYPLTNLDLTPYICSIFRKYPKYNLCAVVNHFG-DLDGGHYTAFCK 333
Cdd:cd02671 225 ITIHLKCFAANGSEFdcygglSKVNT---PLLTPLKLSLEEWSTKPKNDVYRLFAVVMHSGaTISSGHYTAYVR 295
|
|
| Peptidase_C19H |
cd02664 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-336 |
3.53e-16 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239129 [Multi-domain] Cd Length: 327 Bit Score: 77.92 E-value: 3.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLcsilplveyFLTGKYITALQKFLLPSDCSEVATAFAYLMTDMWL----GDSDCVsPEIFWSA 120
Cdd:cd02664 1 GLINLGNTCYMNSVLQAL---------FMAKDFRRQVLSLNLPRLGDSQSVMKKLQLLQAHLmhtqRRAEAP-PDYFLEA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 121 lgNLYPAFTKKMQQDAQEFLICVLNELHealkkyhysrrrsyekgstqrccrkwittetSIITQLFEEQLNYSIVCLKCE 200
Cdd:cd02664 71 --SRPPWFTPGSQQDCSEYLRYLLDRLH-------------------------------TLIEKMFGGKLSTTIRCLNCN 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 201 KCTYKNEVFTVFSLPIPSkyecsLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRF--DIQG 278
Cdd:cd02664 118 STSARTERFRDLDLSFPS-----VQDLLNYFLSPEKLTGDNQYYCEKCASLQDAEKEMKVTGAPEYLILTLLRFsyDQKT 192
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74723115 279 TTKRKLRTDIHYPLTnLDLTPYICSIFRKYPK-------------------YNLCAVVNHFG-DLDGGHYTAFCKNSV 336
Cdd:cd02664 193 HVREKIMDNVSINEV-LSLPVRVESKSSESPLekkeeesgddgelvtrqvhYRLYAVVVHSGySSESGHYFTYARDQT 269
|
|
| Peptidase_C19F |
cd02662 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-337 |
4.86e-15 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239127 [Multi-domain] Cd Length: 240 Bit Score: 73.55 E-value: 4.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLCSILPLVEYfltgkyitaLQKFLlpsdcsevatafaylmtdmwlgdsdcvspeifwsalgnl 124
Cdd:cd02662 1 GLVNLGNTCFMNSVLQALASLPSLIEY---------LEEFL--------------------------------------- 32
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 125 ypaftkkMQQDAQEFLICVLNELHealkkyhysrrrsyekgstqrccrkwittetSIITQLFEEQLNYSIVCLKC-EKCT 203
Cdd:cd02662 33 -------EQQDAHELFQVLLETLE-------------------------------QLLKFPFDGLLASRIVCLQCgESSK 74
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 204 YKNEVFTVFSLPIPSK---YECSLRDCLQCFFQQDALtwnNEIHCSFCETKqetavrasISKAPKIIIFHLKR--FDIQG 278
Cdd:cd02662 75 VRYESFTMLSLPVPNQssgSGTTLEHCLDDFLSTEII---DDYKCDRCQTV--------IVRLPQILCIHLSRsvFDGRG 143
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 279 T-TKRKLRtdIHYPLTnldLTPYicsifrkypKYNLCAVVNHFGDLDGGHYTAFCKNSVT 337
Cdd:cd02662 144 TsTKNSCK--VSFPER---LPKV---------LYRLRAVVVHYGSHSSGHYVCYRRKPLF 189
|
|
| Peptidase_C19M |
cd02669 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
36-319 |
9.16e-15 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239134 [Multi-domain] Cd Length: 440 Bit Score: 74.66 E-value: 9.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 36 NQPHFQGVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITalqkfLLPSDCSEVATAFAYLMTDMWlgdsDC---- 111
Cdd:cd02669 112 GKPYLPGFVGLNNIKNNDYANVIIQALSHVKPIRNFFLLYENYE-----NIKDRKSELVKRLSELIRKIW----NPrnfk 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 112 --VSPEIFWSALGNLYPA-FTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSYekgstQRCCRKWITTETSIITQLfEE 188
Cdd:cd02669 183 ghVSPHELLQAVSKVSKKkFSITEQSDPVEFLSWLLNTLHKDLGGSKKPNSSII-----HDCFQGKVQIETQKIKPH-AE 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 189 QLNYSIVCLKCEKCTYKNEV-FTVFS--LPIPSKYECSLRDCL--QCFFQQdALTWNNEIHCSfcETKqETAVRASISKA 263
Cdd:cd02669 257 EEGSKDKFFKDSRVKKTSVSpFLLLTldLPPPPLFKDGNEENIipQVPLKQ-LLKKYDGKTET--ELK-DSLKRYLISRL 332
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 74723115 264 PKIIIFHLKRFDIQGTTKRKLRTDIHYPLTNLDLTPYICSIFR---KYPKYNLCAVVNH 319
Cdd:cd02669 333 PKYLIFHIKRFSKNNFFKEKNPTIVNFPIKNLDLSDYVHFDKPslnLSTKYNLVANIVH 391
|
|
| COG5533 |
COG5533 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
45-333 |
1.21e-13 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444284 [Multi-domain] Cd Length: 284 Bit Score: 70.22 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLT--GKYITALQKFLlpSDCSEVAT--AFAYLMTDMWLGDSDCVSPEifwsa 120
Cdd:COG5533 1 GLPNLGNTCFMNSVLQILALYLPKLDELLDdlSKELKVLKNVI--RKPEPDLNqeEALKLFTALWSSKEHKVGWI----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 121 lgnlypaFTKKMQQDAQEFLICVLNELhEALKKYHYSRRrsyekgstqrccrKWITTETsiitqlfeeqlnysivclkcE 200
Cdd:COG5533 74 -------PPMGSQEDAHELLGKLLDEL-KLDLVNSFTIR-------------IFKTTKD--------------------K 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 201 KCTYKNEVFTVF-SLPIPSKYECSlrDCLQCFFQQDALTWNNEIHCSFCETKQETAV-----RASISKAPKIIIFHLKRF 274
Cdd:COG5533 113 KKTSTGDWFDIIiELPDQTWVNNL--KTLQEFIDNMEELVDDETGVKAKENEELEVQakqeyEVSFVKLPKILTIQLKRF 190
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 74723115 275 DIQGTtKRKLRTDIHYPLtNLDLTPYICSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCK 333
Cdd:COG5533 191 ANLGG-NQKIDTEVDEKF-ELPVKHDQILNIVKETYYDLVGFVLHQGSLEGGHYIAYVK 247
|
|
| COG5077 |
COG5077 |
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ... |
42-336 |
1.69e-08 |
|
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227409 [Multi-domain] Cd Length: 1089 Bit Score: 56.03 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 42 GVTGLWNLGNTCCVNAISQCLCSIlplvEYFLTGKYITALQKfllPSDCSEVATAFAYLMTDMWLGDSDCVSPEIFWSal 121
Cdd:COG5077 192 GYVGLRNQGATCYMNSLLQSLFFI----AKFRKDVYGIPTDH---PRGRDSVALALQRLFYNLQTGEEPVDTTELTRS-- 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 122 gNLYPAFTKKMQQDAQEFLICVLNELHEALKKyhysrrrsyekgstqrccrkwiTTETSIITQLFEEQLNYSIVCLKCEK 201
Cdd:COG5077 263 -FGWDSDDSFMQHDIQEFNRVLQDNLEKSMRG----------------------TVVENALNGIFVGKMKSYIKCVNVNY 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 202 CTYKNEVFtvFSLPIPSKYECSLRDCLQCFFQQDALTWNNeihCSFCETK--QETAVRASISKAPKIIIFHLKRFDIQGT 279
Cdd:COG5077 320 ESARVEDF--WDIQLNVKGMKNLQESFRRYIQVETLDGDN---RYNAEKHglQDAKKGVIFESLPPVLHLQLKRFEYDFE 394
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74723115 280 TKR--KLRTDIHYPLTnLDLTPYICSIFRKYPK----YNLCAVVNHFGDLDGGHYTAFCKNSV 336
Cdd:COG5077 395 RDMmvKINDRYEFPLE-IDLLPFLDRDADKSENsdavYVLYGVLVHSGDLHEGHYYALLKPEK 456
|
|
| Peptidase_C19J |
cd02666 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
44-328 |
1.71e-08 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239131 [Multi-domain] Cd Length: 343 Bit Score: 55.19 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 44 TGLWNLGNTCCVNAISQCLCSILPLVEYFLTgkyiTALQKFLLPSDCSE---------------VATAFAY----LMTDM 104
Cdd:cd02666 2 AGLDNIGNTCYLNSLLQYFFTIKPLRDLVLN----FDESKAELASDYPTerriggrevsrselqRSNQFVYelrsLFNDL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 105 WLGDSDCVSPEifwSALGNLypAFTkkmQQDAQEFLICVLNELHEALKKYHYSRRRSYEKGSTQrccrkwittETSIITQ 184
Cdd:cd02666 78 IHSNTRSVTPS---KELAYL--ALR---QQDVTECIDNVLFQLEVALEPISNAFAGPDTEDDKE---------QSDLIKR 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 185 LFEEQLNYSIVCLKCE---KCTYKNEVFtvFSLPIPSKYE----------CSLRDCLQCFFQQDALT-----WNNEIHCS 246
Cdd:cd02666 141 LFSGKTKQQLVPESMGnqpSVRTKTERF--LSLLVDVGKKgreivvllepKDLYDALDRYFDYDSLTklpqrSQVQAQLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 247 FCETKQETAVR----ASISKAPKIIIFHLKRfdiqgtTKRKLRTDIHYPLTNLDLTpyICSIF---RKYPkYNLCAVVNH 319
Cdd:cd02666 219 QPLQRELISMDryelPSSIDDIDELIREAIQ------SESSLVRQAQNELAELKHE--IEKQFddlKSYG-YRLHAVFIH 289
|
....*....
gi 74723115 320 FGDLDGGHY 328
Cdd:cd02666 290 RGEASSGHY 298
|
|
| Peptidase_C19Q |
cd02673 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
119-335 |
7.69e-08 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239138 [Multi-domain] Cd Length: 245 Bit Score: 52.53 E-value: 7.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 119 SALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSYEKGSTQRCCRKW-ITTETSIitqlfeeqlnysiVCL 197
Cdd:cd02673 19 SSIGKINTEFDNDDQQDAHEFLLTLLEAIDDIMQVNRTNVPPSNIEIKRLNPLEAFkYTIESSY-------------VCI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 198 KCEKCTYKNEVFTVFSLPIPSKYECSLRDCLQCFFqqdalTWNN-EIHCSFCETkQETAVRASISKAPKIIIFHLKRFDI 276
Cdd:cd02673 86 GCSFEENVSDVGNFLDVSMIDNKLDIDELLISNFK-----TWSPiEKDCSSCKC-ESAISSERIMTFPECLSINLKRYKL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74723115 277 QGTTKRKLRTDihypltnldltpyiCSIFRKY----PKYNLCAVVNHFGDL-DGGHYTAFCKNS 335
Cdd:cd02673 160 RIATSDYLKKN--------------EEIMKKYcgtdAKYSLVAVICHLGESpYDGHYIAYTKEL 209
|
|
| Peptidase_C19I |
cd02665 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
205-331 |
7.38e-04 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239130 [Multi-domain] Cd Length: 228 Bit Score: 40.23 E-value: 7.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723115 205 KNEVFtvFSLPIPSKYECSLRDCLQcffqqdALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTTKRKL 284
Cdd:cd02665 78 NCETF--GQYPLQVNGYGNLHECLE------AAMFEGEVELLPSDHSVKSGQERWFTELPPVLTFELSRFEFNQGRPEKI 149
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90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 74723115 285 RTDIHYPltnldltpyicSIFRKYPkYNLCAVVNHFGDLDGGHYTAF 331
Cdd:cd02665 150 HDKLEFP-----------QIIQQVP-YELHAVLVHEGQANAGHYWAY 184
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