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Conserved domains on  [gi|81830492|sp|Q72E53|]
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RecName: Full=Queuine tRNA-ribosyltransferase; AltName: Full=Guanine insertion enzyme; AltName: Full=tRNA-guanine transglycosylase

Protein Classification

tRNA guanosine(34) transglycosylase Tgt( domain architecture ID 11417414)

tRNA guanosine(34) transglycosylase Tgt catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 in tRNAs with GU(N) anticodons resulting in the hypermodified nucleoside queuosine

CATH:  3.20.20.105
EC:  2.4.2.-
Gene Ontology:  GO:0008479|GO:0046872
PubMed:  19925456

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tgt COG0343
Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; ...
6-346 0e+00

Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Queuine/archaeosine tRNA-ribosyltransferase is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440112  Cd Length: 370  Bit Score: 686.00  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   6 TFEIHATD-GAARTGCLHTAHGIVRTPIFMPVGTVGSVKAIAPDDLEAIGAEIILGNTYHLYLRPGDELVARRGGLHEFN 84
Cdd:COG0343   4 KFELLATDpGKARRGRLTTPHGTIETPAFMPVGTQATVKALTPEELKEIGAQIILGNTYHLYLRPGAEVIAKAGGLHKFM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492  85 AWRKPILTDSGGFQVFSLSGLRRIAEEGVEFRSHLDGSKHLFTPEKVVSIQRNLNSDIMMVLDECVPYGADRTYTEKSVG 164
Cdd:COG0343  84 NWDGPILTDSGGFQVFSLAKLRKITEEGVTFRSHIDGSKHFLTPEKSMEIQRALGSDIIMAFDECTPYPATYEYAKKSME 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492 165 LTTRWAKRCRDAYpKGAAGNLLFGITQGGFFKDLRTRSIGALTDIDFDGFALGGLSVGEPKAEMMDLLYHSAPLLPADKP 244
Cdd:COG0343 164 RTLRWAERCKAAH-KRLPDQALFGIVQGGMYEDLRKESAEALVELDFDGYAIGGLSVGEPKEEMYEILEYTTPLLPEDKP 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492 245 RYLMGVGTPLDIINGIAAGVDMFDCVLPTRNARNGTLYTSLGKLNIKRREFAEDDGPLDPACSCYTCRTFSRAYLRHLYT 324
Cdd:COG0343 243 RYLMGVGTPEDLLEAVARGVDMFDCVLPTRNARNGTAFTSQGRINIRNARYKEDFRPLDPECDCYTCRNYSRAYLRHLFK 322
                       330       340
                ....*....|....*....|..
gi 81830492 325 AKELLAFRLNSIHNLTYFLDLV 346
Cdd:COG0343 323 AGEILGARLLTIHNLHFYLRLM 344
 
Name Accession Description Interval E-value
Tgt COG0343
Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; ...
6-346 0e+00

Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Queuine/archaeosine tRNA-ribosyltransferase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440112  Cd Length: 370  Bit Score: 686.00  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   6 TFEIHATD-GAARTGCLHTAHGIVRTPIFMPVGTVGSVKAIAPDDLEAIGAEIILGNTYHLYLRPGDELVARRGGLHEFN 84
Cdd:COG0343   4 KFELLATDpGKARRGRLTTPHGTIETPAFMPVGTQATVKALTPEELKEIGAQIILGNTYHLYLRPGAEVIAKAGGLHKFM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492  85 AWRKPILTDSGGFQVFSLSGLRRIAEEGVEFRSHLDGSKHLFTPEKVVSIQRNLNSDIMMVLDECVPYGADRTYTEKSVG 164
Cdd:COG0343  84 NWDGPILTDSGGFQVFSLAKLRKITEEGVTFRSHIDGSKHFLTPEKSMEIQRALGSDIIMAFDECTPYPATYEYAKKSME 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492 165 LTTRWAKRCRDAYpKGAAGNLLFGITQGGFFKDLRTRSIGALTDIDFDGFALGGLSVGEPKAEMMDLLYHSAPLLPADKP 244
Cdd:COG0343 164 RTLRWAERCKAAH-KRLPDQALFGIVQGGMYEDLRKESAEALVELDFDGYAIGGLSVGEPKEEMYEILEYTTPLLPEDKP 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492 245 RYLMGVGTPLDIINGIAAGVDMFDCVLPTRNARNGTLYTSLGKLNIKRREFAEDDGPLDPACSCYTCRTFSRAYLRHLYT 324
Cdd:COG0343 243 RYLMGVGTPEDLLEAVARGVDMFDCVLPTRNARNGTAFTSQGRINIRNARYKEDFRPLDPECDCYTCRNYSRAYLRHLFK 322
                       330       340
                ....*....|....*....|..
gi 81830492 325 AKELLAFRLNSIHNLTYFLDLV 346
Cdd:COG0343 323 AGEILGARLLTIHNLHFYLRLM 344
TGT pfam01702
Queuine tRNA-ribosyltransferase; This is a family of queuine tRNA-ribosyltransferases EC:2.4.2. ...
13-346 0e+00

Queuine tRNA-ribosyltransferase; This is a family of queuine tRNA-ribosyltransferases EC:2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine. It catalyzes the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified base queuine in the wobble position. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H, and important tRNA and 7-aminomethyl-7deazaguanine binding residues.


Pssm-ID: 460299  Cd Length: 358  Bit Score: 601.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492    13 DGAARTGCLHTAHGIVRTPIFMPVGTVGSVKAIAPDDLEAIGAEIILGNTYHLYLRPGDELVARRGGLHEFNAWRKPILT 92
Cdd:pfam01702   1 DGAARLGRLTTPHGVIETPAFMPVGTQGTVKGLTPDELKELGAQIILGNTYHLYLRPGLELVAKAGGLHKFMGWDGPILT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492    93 DSGGFQVFSLSGLRRIAEEGVEFRSHLDGSKHLFTPEKVVSIQRNLNSDIMMVLDECVPYGADRTYTEKSVGLTTRWAKR 172
Cdd:pfam01702  81 DSGGFQVFSLAKLRKITEEGVTFRSHIDGSKHFLTPEESMEIQEALGSDIAMALDECTPYPASRKRAEKSVERTLRWAER 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   173 CRDAYpKGAAGNLLFGITQGGFFKDLRTRSIGALTDIDFDGFALGGLSVGEPKAEMMDLLYHSAPLLPADKPRYLMGVGT 252
Cdd:pfam01702 161 CLEAH-KRPEDQALFGIVQGGLYPDLREESAEELAELDFDGYAIGGLSVGEPKEEMYEIVEATTPLLPEDKPRYLMGVGT 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   253 PLDIINGIAAGVDMFDCVLPTRNARNGTLYTSLGKLNIKRREFAEDDGPLDPACSCYTCRTFSRAYLRHLYTAKELLAFR 332
Cdd:pfam01702 240 PEDILEAVALGVDMFDCVYPTRNARNGRALTSEGTLNLRNAKYAEDFRPLDEGCSCYTCRNYSRAYLRHLLKAKEMLGAR 319
                         330
                  ....*....|....
gi 81830492   333 LNSIHNLTYFLDLV 346
Cdd:pfam01702 320 LLTIHNLHFYLELM 333
Q_tRNA_tgt TIGR00430
tRNA-guanine transglycosylase; This tRNA-guanine transglycosylase (tgt) catalyzes an exchange ...
7-373 0e+00

tRNA-guanine transglycosylase; This tRNA-guanine transglycosylase (tgt) catalyzes an exchange for the guanine base at position 34 of many tRNAs; this nucleotide is subsequently modified to queuosine. The Archaea have a closely related enzyme that catalyzes a base exchange for guanine at position 15 in some tRNAs, a site that is subsequently converted to the archaeal-specific modified base archaeosine (7-formamidino-7-deazaguanosine), while Archaeoglobus fulgidus has both enzymes. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129522  Cd Length: 368  Bit Score: 544.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492     7 FEIHATDGAARTGCLHTAHGIVRTPIFMPVGTVGSVKAIAPDDLEAIGAEIILGNTYHLYLRPGDELVARRGGLHEFNAW 86
Cdd:TIGR00430   1 FELQKTDKHARVGKLNTPHGSVETPVFMPVGTLGTVKGLTPEELEATGAEIILANTYHLWLRPGQKIVKELGGLHKFMQW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492    87 RKPILTDSGGFQVFSLSGLRRIAEEGVEFRSHLDGSKHLFTPEKVVSIQRNLNSDIMMVLDECVPYGADRTYTEKSVGLT 166
Cdd:TIGR00430  81 DGPILTDSGGFQVFSLSDLRKIEEEGVHFKSPIDGSKIFLTPEKSMEIQYALGSDIIMAFDECTPYPADRDYAEKSTERT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   167 TRWAKRCRDAYPKGAAGNLLFGITQGGFFKDLRTRSIGALTDIDFDGFALGGLSVGEPKAEMMDLLYHSAPLLPADKPRY 246
Cdd:TIGR00430 161 LRWAERCLEAHDRRGNKQALFGIVQGGTYEDLRSQSAEGLIELDFPGYAIGGLSVGEPKEDMLRILEHTAPLLPKDKPRY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   247 LMGVGTPLDIINGIAAGVDMFDCVLPTRNARNGTLYTSLGKLNIKRREFAEDDGPLDPACSCYTCRTFSRAYLRHLYTAK 326
Cdd:TIGR00430 241 LMGVGTPEDLLNAIRRGIDMFDCVMPTRNARNGTLFVTEGRINIKNAKYKDDTRPLDEECDCYTCKNYSRAYLRHLIRCN 320
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 81830492   327 ELLAFRLNSIHNLTYFLDLVRGARAAIAAGRFAEYKRSFEAIYPEEV 373
Cdd:TIGR00430 321 ELLGARLATLHNLHFYLRLMEKIRQAILEDRFLSFRTEFLERYGEEV 367
PRK01008 PRK01008
queuine tRNA-ribosyltransferase; Provisional
16-346 5.69e-101

queuine tRNA-ribosyltransferase; Provisional


Pssm-ID: 134464  Cd Length: 372  Bit Score: 303.28  E-value: 5.69e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   16 ARTGCLHTAHGIVRTPIFMPVGTVGSVKAIapddLEAIGAEIILGNTYHLYLRPGDELVARRGGLHEFNAWRKPILTDSG 95
Cdd:PRK01008  16 ARVGRIETAHGIIDTPAFVPVATNGALKGV----LDHSNIPLMFCNTYHLLVHPGTEAIAAMGGLHQFIGRNAPIITDSG 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   96 GFQVFSL------------------SGLRRIAEEGVEFRSHLDGSKHLFTPEKVVSIQRNLNSDIMMVLDECVPYGADRT 157
Cdd:PRK01008  92 GFQIFSLaygsvaeeikscgkkkggSSILKITDEGVWFKSYRDGRKLFLSPEISVQAQKDLGADIIIPLDELLPFHADPT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492  158 YTEKSVGLTTRWAKRCRDAYPKGAAGNLLFGITQGGFFKDLRTRSIGALTDIDFDGFALGGlSVGEPKAEMMDLLYHSAP 237
Cdd:PRK01008 172 YFLQSCQRTYVWEKRSLDYHLKNPRHQSMYGVIHGGIDPDQRKIGCKFVEDLPFDGSAIGG-SLGKNLQEMVEVVGVTTS 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492  238 LLPADKPRYLMGVGTPLDIINGIAAGVDMFDCVLPTRNARNGTLYTSLGKLNIKRREFAEDDGPLDPACSCYTCRT-FSR 316
Cdd:PRK01008 251 NLSKERPVHLLGIGDLPSIWATVGFGIDSFDSSYPTKAARHGLILTKQGPLKINNQRYSSDLNPIEPGCSCLACSSgISR 330
                        330       340       350
                 ....*....|....*....|....*....|
gi 81830492  317 AYLRHLYTAKELLAFRLNSIHNLTYFLDLV 346
Cdd:PRK01008 331 AYLRHLFKVHEPNAGIWASIHNLHHMQQVM 360
 
Name Accession Description Interval E-value
Tgt COG0343
Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; ...
6-346 0e+00

Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Queuine/archaeosine tRNA-ribosyltransferase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440112  Cd Length: 370  Bit Score: 686.00  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   6 TFEIHATD-GAARTGCLHTAHGIVRTPIFMPVGTVGSVKAIAPDDLEAIGAEIILGNTYHLYLRPGDELVARRGGLHEFN 84
Cdd:COG0343   4 KFELLATDpGKARRGRLTTPHGTIETPAFMPVGTQATVKALTPEELKEIGAQIILGNTYHLYLRPGAEVIAKAGGLHKFM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492  85 AWRKPILTDSGGFQVFSLSGLRRIAEEGVEFRSHLDGSKHLFTPEKVVSIQRNLNSDIMMVLDECVPYGADRTYTEKSVG 164
Cdd:COG0343  84 NWDGPILTDSGGFQVFSLAKLRKITEEGVTFRSHIDGSKHFLTPEKSMEIQRALGSDIIMAFDECTPYPATYEYAKKSME 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492 165 LTTRWAKRCRDAYpKGAAGNLLFGITQGGFFKDLRTRSIGALTDIDFDGFALGGLSVGEPKAEMMDLLYHSAPLLPADKP 244
Cdd:COG0343 164 RTLRWAERCKAAH-KRLPDQALFGIVQGGMYEDLRKESAEALVELDFDGYAIGGLSVGEPKEEMYEILEYTTPLLPEDKP 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492 245 RYLMGVGTPLDIINGIAAGVDMFDCVLPTRNARNGTLYTSLGKLNIKRREFAEDDGPLDPACSCYTCRTFSRAYLRHLYT 324
Cdd:COG0343 243 RYLMGVGTPEDLLEAVARGVDMFDCVLPTRNARNGTAFTSQGRINIRNARYKEDFRPLDPECDCYTCRNYSRAYLRHLFK 322
                       330       340
                ....*....|....*....|..
gi 81830492 325 AKELLAFRLNSIHNLTYFLDLV 346
Cdd:COG0343 323 AGEILGARLLTIHNLHFYLRLM 344
TGT pfam01702
Queuine tRNA-ribosyltransferase; This is a family of queuine tRNA-ribosyltransferases EC:2.4.2. ...
13-346 0e+00

Queuine tRNA-ribosyltransferase; This is a family of queuine tRNA-ribosyltransferases EC:2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine. It catalyzes the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified base queuine in the wobble position. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H, and important tRNA and 7-aminomethyl-7deazaguanine binding residues.


Pssm-ID: 460299  Cd Length: 358  Bit Score: 601.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492    13 DGAARTGCLHTAHGIVRTPIFMPVGTVGSVKAIAPDDLEAIGAEIILGNTYHLYLRPGDELVARRGGLHEFNAWRKPILT 92
Cdd:pfam01702   1 DGAARLGRLTTPHGVIETPAFMPVGTQGTVKGLTPDELKELGAQIILGNTYHLYLRPGLELVAKAGGLHKFMGWDGPILT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492    93 DSGGFQVFSLSGLRRIAEEGVEFRSHLDGSKHLFTPEKVVSIQRNLNSDIMMVLDECVPYGADRTYTEKSVGLTTRWAKR 172
Cdd:pfam01702  81 DSGGFQVFSLAKLRKITEEGVTFRSHIDGSKHFLTPEESMEIQEALGSDIAMALDECTPYPASRKRAEKSVERTLRWAER 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   173 CRDAYpKGAAGNLLFGITQGGFFKDLRTRSIGALTDIDFDGFALGGLSVGEPKAEMMDLLYHSAPLLPADKPRYLMGVGT 252
Cdd:pfam01702 161 CLEAH-KRPEDQALFGIVQGGLYPDLREESAEELAELDFDGYAIGGLSVGEPKEEMYEIVEATTPLLPEDKPRYLMGVGT 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   253 PLDIINGIAAGVDMFDCVLPTRNARNGTLYTSLGKLNIKRREFAEDDGPLDPACSCYTCRTFSRAYLRHLYTAKELLAFR 332
Cdd:pfam01702 240 PEDILEAVALGVDMFDCVYPTRNARNGRALTSEGTLNLRNAKYAEDFRPLDEGCSCYTCRNYSRAYLRHLLKAKEMLGAR 319
                         330
                  ....*....|....
gi 81830492   333 LNSIHNLTYFLDLV 346
Cdd:pfam01702 320 LLTIHNLHFYLELM 333
Q_tRNA_tgt TIGR00430
tRNA-guanine transglycosylase; This tRNA-guanine transglycosylase (tgt) catalyzes an exchange ...
7-373 0e+00

tRNA-guanine transglycosylase; This tRNA-guanine transglycosylase (tgt) catalyzes an exchange for the guanine base at position 34 of many tRNAs; this nucleotide is subsequently modified to queuosine. The Archaea have a closely related enzyme that catalyzes a base exchange for guanine at position 15 in some tRNAs, a site that is subsequently converted to the archaeal-specific modified base archaeosine (7-formamidino-7-deazaguanosine), while Archaeoglobus fulgidus has both enzymes. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129522  Cd Length: 368  Bit Score: 544.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492     7 FEIHATDGAARTGCLHTAHGIVRTPIFMPVGTVGSVKAIAPDDLEAIGAEIILGNTYHLYLRPGDELVARRGGLHEFNAW 86
Cdd:TIGR00430   1 FELQKTDKHARVGKLNTPHGSVETPVFMPVGTLGTVKGLTPEELEATGAEIILANTYHLWLRPGQKIVKELGGLHKFMQW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492    87 RKPILTDSGGFQVFSLSGLRRIAEEGVEFRSHLDGSKHLFTPEKVVSIQRNLNSDIMMVLDECVPYGADRTYTEKSVGLT 166
Cdd:TIGR00430  81 DGPILTDSGGFQVFSLSDLRKIEEEGVHFKSPIDGSKIFLTPEKSMEIQYALGSDIIMAFDECTPYPADRDYAEKSTERT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   167 TRWAKRCRDAYPKGAAGNLLFGITQGGFFKDLRTRSIGALTDIDFDGFALGGLSVGEPKAEMMDLLYHSAPLLPADKPRY 246
Cdd:TIGR00430 161 LRWAERCLEAHDRRGNKQALFGIVQGGTYEDLRSQSAEGLIELDFPGYAIGGLSVGEPKEDMLRILEHTAPLLPKDKPRY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   247 LMGVGTPLDIINGIAAGVDMFDCVLPTRNARNGTLYTSLGKLNIKRREFAEDDGPLDPACSCYTCRTFSRAYLRHLYTAK 326
Cdd:TIGR00430 241 LMGVGTPEDLLNAIRRGIDMFDCVMPTRNARNGTLFVTEGRINIKNAKYKDDTRPLDEECDCYTCKNYSRAYLRHLIRCN 320
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 81830492   327 ELLAFRLNSIHNLTYFLDLVRGARAAIAAGRFAEYKRSFEAIYPEEV 373
Cdd:TIGR00430 321 ELLGARLATLHNLHFYLRLMEKIRQAILEDRFLSFRTEFLERYGEEV 367
tgt_general TIGR00449
tRNA-guanine family transglycosylase; Different tRNA-guanine transglycosylases catalyze ...
7-373 0e+00

tRNA-guanine family transglycosylase; Different tRNA-guanine transglycosylases catalyze different tRNA base modifications. Two guanine base substitutions by different enzymes described by the model are involved in generating queuosine at position 34 in bacterial tRNAs and archaeosine at position 15 in archaeal tRNAs. This model is designed for fragment searching, so the superfamily is used loosely. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129541  Cd Length: 367  Bit Score: 520.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492     7 FEIHATDGAARTGCLHTAHGIVRTPIFMPVGTVGSVKAIAPDDLEAIGAEIILGNTYHLYLRPGDELVARRGGLHEFNAW 86
Cdd:TIGR00449   1 FEIKKTDGHARVGRLKTPHGSVETPVFMPVGTLGTVKGLTPEELKKTGAQIILANTYHLYLRPGQKIVALLGGLHKFMQW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492    87 RKPILTDSGGFQVFSLSGLRRIAEEGVEFRSHLDGSKHLFTPEKVVSIQRNLNSDIMMVLDECVPYGADRTYTEKSVGLT 166
Cdd:TIGR00449  81 DGPILTDSGGFQVFSLGDLRKIEEEGVHFKSPIDGSKIFLTPEKIMEIQYALGSDIIMALDECTPPPADYDYAEESLERT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   167 TRWAKRCRDAYpKGAAGNLLFGITQGGFFKDLRTRSIGALTDIDFDGFALGGLSVGEPKAEMMDLLYHSAPLLPADKPRY 246
Cdd:TIGR00449 161 LRWAEESLEYH-KRRNENALFGIVQGGTYPDLRRQSAEGLAELDFDGYAIGGVSVGEPKRDMLRILEHVAPLLPKDKPRY 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   247 LMGVGTPLDIINGIAAGVDMFDCVLPTRNARNGTLYTSLGKLNIKRREFAEDDGPLDPACSCYTCRTFSRAYLRHLYTAK 326
Cdd:TIGR00449 240 LMGVGTPELLANAVSLGIDMFDCVAPTRYARNGTLLTTEGRIKIKNAKYKDDTRPLDEPCDCYVCKNYSRAYLRHLIRCN 319
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 81830492   327 ELLAFRLNSIHNLTYFLDLVRGARAAIAAGRFAEYKRSFEAIYPEEV 373
Cdd:TIGR00449 320 ELLGARLATEHNLHFSFRLIEKIRQAILEDRLLSFVEEFLEAYGRLL 366
PRK01008 PRK01008
queuine tRNA-ribosyltransferase; Provisional
16-346 5.69e-101

queuine tRNA-ribosyltransferase; Provisional


Pssm-ID: 134464  Cd Length: 372  Bit Score: 303.28  E-value: 5.69e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   16 ARTGCLHTAHGIVRTPIFMPVGTVGSVKAIapddLEAIGAEIILGNTYHLYLRPGDELVARRGGLHEFNAWRKPILTDSG 95
Cdd:PRK01008  16 ARVGRIETAHGIIDTPAFVPVATNGALKGV----LDHSNIPLMFCNTYHLLVHPGTEAIAAMGGLHQFIGRNAPIITDSG 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492   96 GFQVFSL------------------SGLRRIAEEGVEFRSHLDGSKHLFTPEKVVSIQRNLNSDIMMVLDECVPYGADRT 157
Cdd:PRK01008  92 GFQIFSLaygsvaeeikscgkkkggSSILKITDEGVWFKSYRDGRKLFLSPEISVQAQKDLGADIIIPLDELLPFHADPT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492  158 YTEKSVGLTTRWAKRCRDAYPKGAAGNLLFGITQGGFFKDLRTRSIGALTDIDFDGFALGGlSVGEPKAEMMDLLYHSAP 237
Cdd:PRK01008 172 YFLQSCQRTYVWEKRSLDYHLKNPRHQSMYGVIHGGIDPDQRKIGCKFVEDLPFDGSAIGG-SLGKNLQEMVEVVGVTTS 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81830492  238 LLPADKPRYLMGVGTPLDIINGIAAGVDMFDCVLPTRNARNGTLYTSLGKLNIKRREFAEDDGPLDPACSCYTCRT-FSR 316
Cdd:PRK01008 251 NLSKERPVHLLGIGDLPSIWATVGFGIDSFDSSYPTKAARHGLILTKQGPLKINNQRYSSDLNPIEPGCSCLACSSgISR 330
                        330       340       350
                 ....*....|....*....|....*....|
gi 81830492  317 AYLRHLYTAKELLAFRLNSIHNLTYFLDLV 346
Cdd:PRK01008 331 AYLRHLFKVHEPNAGIWASIHNLHHMQQVM 360
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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