NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|81911988|sp|Q7TMQ7|]
View 

RecName: Full=WD repeat-containing protein 91

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
408-746 9.52e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 9.52e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 408 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 486
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 487 LCEININDDmpRILSLACSPNGASFVcsaaapsltsqtdSSAPDigskgmnqvpGKLLLWDTKTmkQQLQFSLDPEPIAI 566
Cdd:COG2319 155 LRTLTGHSG--AVTSVAFSPDGKLLA-------------SGSDD----------GTVRLWDLAT--GKLLRTLTGHTGAV 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 567 NCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWNIhksglkvsesnl 646
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------------ 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 647 psdATGPFV--LSGYSGykqvqvpRGRLFAFDSEGNYMLTCSATGGL-IYKLGSEEKVlencLSLGGHRAPVVTVDWSTa 723
Cdd:COG2319 276 ---ATGELLrtLTGHSG-------GVNSVAFSPDGKLLASGSDDGTVrLWDLATGKLL----RTLTGHTGAVRSVAFSP- 340

                       330       340       350
                ....*....|....*....|....*....|..
gi 81911988 724 mDCGTCLTASMDGKIKL---------TTLLAH 746
Cdd:COG2319 341 -DGKTLASGSDDGTVRLwdlatgellRTLTGH 371
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
408-746 9.52e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 9.52e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 408 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 486
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 487 LCEININDDmpRILSLACSPNGASFVcsaaapsltsqtdSSAPDigskgmnqvpGKLLLWDTKTmkQQLQFSLDPEPIAI 566
Cdd:COG2319 155 LRTLTGHSG--AVTSVAFSPDGKLLA-------------SGSDD----------GTVRLWDLAT--GKLLRTLTGHTGAV 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 567 NCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWNIhksglkvsesnl 646
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------------ 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 647 psdATGPFV--LSGYSGykqvqvpRGRLFAFDSEGNYMLTCSATGGL-IYKLGSEEKVlencLSLGGHRAPVVTVDWSTa 723
Cdd:COG2319 276 ---ATGELLrtLTGHSG-------GVNSVAFSPDGKLLASGSDDGTVrLWDLATGKLL----RTLTGHTGAVRSVAFSP- 340

                       330       340       350
                ....*....|....*....|....*....|..
gi 81911988 724 mDCGTCLTASMDGKIKL---------TTLLAH 746
Cdd:COG2319 341 -DGKTLASGSDDGTVRLwdlatgellRTLTGH 371
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-740 1.48e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.56  E-value: 1.48e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 408 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNL 487
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 488 CEININDDMprILSLACSPNGaSFVCSaaapsltSQTDssapdigskgmnqvpGKLLLWDTKTMKQqlQFSLDPEPIAIN 567
Cdd:cd00200  87 RTLTGHTSY--VSSVAFSPDG-RILSS-------SSRD---------------KTIKVWDVETGKC--LTTLRGHTDWVN 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 568 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWNIHKSglkvsesnlp 647
Cdd:cd00200 140 SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---------- 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 648 sdatgpfvlsgysgyKQVQVPRGRLF-----AFDSEGNYMLTCSATGGL-IYKLGSEEKVLEnclsLGGHRAPVVTVDWS 721
Cdd:cd00200 210 ---------------KCLGTLRGHENgvnsvAFSPDGYLLASGSEDGTIrVWDLRTGECVQT----LSGHTNSVTSLAWS 270

                       330
                ....*....|....*....
gi 81911988 722 TamDCGTCLTASMDGKIKL 740
Cdd:cd00200 271 P--DGKRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 565-591 9.50e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 9.50e-05
                           10        20
                   ....*....|....*....|....*..
gi 81911988    565 AINCTAFNHNGNLLVTGAADGVIRLFD 591
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 556-616 8.44e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 8.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81911988   556 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCD 616
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
408-746 9.52e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 9.52e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 408 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 486
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 487 LCEININDDmpRILSLACSPNGASFVcsaaapsltsqtdSSAPDigskgmnqvpGKLLLWDTKTmkQQLQFSLDPEPIAI 566
Cdd:COG2319 155 LRTLTGHSG--AVTSVAFSPDGKLLA-------------SGSDD----------GTVRLWDLAT--GKLLRTLTGHTGAV 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 567 NCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWNIhksglkvsesnl 646
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------------ 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 647 psdATGPFV--LSGYSGykqvqvpRGRLFAFDSEGNYMLTCSATGGL-IYKLGSEEKVlencLSLGGHRAPVVTVDWSTa 723
Cdd:COG2319 276 ---ATGELLrtLTGHSG-------GVNSVAFSPDGKLLASGSDDGTVrLWDLATGKLL----RTLTGHTGAVRSVAFSP- 340

                       330       340       350
                ....*....|....*....|....*....|..
gi 81911988 724 mDCGTCLTASMDGKIKL---------TTLLAH 746
Cdd:COG2319 341 -DGKTLASGSDDGTVRLwdlatgellRTLTGH 371
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-740 1.48e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.56  E-value: 1.48e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 408 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNL 487
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 488 CEININDDMprILSLACSPNGaSFVCSaaapsltSQTDssapdigskgmnqvpGKLLLWDTKTMKQqlQFSLDPEPIAIN 567
Cdd:cd00200  87 RTLTGHTSY--VSSVAFSPDG-RILSS-------SSRD---------------KTIKVWDVETGKC--LTTLRGHTDWVN 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 568 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWNIHKSglkvsesnlp 647
Cdd:cd00200 140 SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---------- 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 648 sdatgpfvlsgysgyKQVQVPRGRLF-----AFDSEGNYMLTCSATGGL-IYKLGSEEKVLEnclsLGGHRAPVVTVDWS 721
Cdd:cd00200 210 ---------------KCLGTLRGHENgvnsvAFSPDGYLLASGSEDGTIrVWDLRTGECVQT----LSGHTNSVTSLAWS 270

                       330
                ....*....|....*....
gi 81911988 722 TamDCGTCLTASMDGKIKL 740
Cdd:cd00200 271 P--DGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
408-634 8.82e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 8.82e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 408 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKrDRLLLLGSGVGTVRLYDTEAKKNL 487
Cdd:COG2319 203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELL 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 488 CEININDDmpRILSLACSPNGASFVcsaaapsltsqtdSSAPDigskgmnqvpGKLLLWDTKTmkQQLQFSLDPEPIAIN 567
Cdd:COG2319 282 RTLTGHSG--GVNSVAFSPDGKLLA-------------SGSDD----------GTVRLWDLAT--GKLLRTLTGHTGAVR 334

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81911988 568 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWNI 634
Cdd:COG2319 335 SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-633 7.46e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 7.46e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 404 EYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKA--------SSISKSPllslewatkrDRLLLLGSGV-G 474
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTlrghtdwvNSVAFSP----------DGTFVASSSQdG 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 475 TVRLYDTEAKKnlCEININDDMPRILSLACSPNGASFVCSAAapsltsqtDSSApdigskgmnqvpgklLLWDTKTMKQQ 554
Cdd:cd00200 158 TIKLWDLRTGK--CVATLTGHTGEVNSVAFSPDGEKLLSSSS--------DGTI---------------KLWDLSTGKCL 212

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81911988 555 LQFSLDPEPIaiNCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWN 633
Cdd:cd00200 213 GTLRGHENGV--NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
421-593 1.13e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 1.13e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 421 GRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDDmpRIL 500
Cdd:COG2319 258 GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVR 334

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 501 SLACSPNGASFVcsaaapsltsqtdSSAPDigskgmnqvpGKLLLWDTKTMKQQLQFSLDPEPIaiNCTAFNHNGNLLVT 580
Cdd:COG2319 335 SVAFSPDGKTLA-------------SGSDD----------GTVRLWDLATGELLRTLTGHTGAV--TSVAFSPDGRTLAS 389

                       170
                ....*....|...
gi 81911988 581 GAADGVIRLFDMQ 593
Cdd:COG2319 390 GSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
513-740 1.20e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 1.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 513 CSAAAPSLTSQTDSSAPDIGSKGMNQVPGKLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDM 592
Cdd:COG2319  28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 593 QQHECAMSWKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWNIhKSGLKVSESNLPSDA--------TGPFVLSGySGYKQ 664
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAvtsvafspDGKLLASG-SDDGT 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 665 VQV---PRGRLF-------------AFDSEGNYMLTCSATGGL-IYKLGSEEKVlencLSLGGHRAPVVTVDWSTamDCG 727
Cdd:COG2319 186 VRLwdlATGKLLrtltghtgavrsvAFSPDGKLLASGSADGTVrLWDLATGKLL----RTLTGHSGSVRSVAFSP--DGR 259

                       250
                ....*....|...
gi 81911988 728 TCLTASMDGKIKL 740
Cdd:COG2319 260 LLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 601-747 4.19e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 4.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81911988 601 WKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWNIhksglkvsesnlpsdATGPFVLSGYSGYKQVQVprgrlFAFDSEGN 680
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL---------------ETGELLRTLKGHTGPVRD-----VAASADGT 64

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81911988 681 YMLTCSATGGL-IYKLGSEEKVLEnclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL---------TTLLAHK 747
Cdd:cd00200  65 YLASGSSDKTIrLWDLETGECVRT----LTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVwdvetgkclTTLRGHT 135
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 565-591 9.50e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 9.50e-05
                           10        20
                   ....*....|....*....|....*..
gi 81911988    565 AINCTAFNHNGNLLVTGAADGVIRLFD 591
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 556-616 8.44e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 8.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81911988   556 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCD 616
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
565-591 1.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|....*..
gi 81911988   565 AINCTAFNHNGNLLVTGAADGVIRLFD 591
Cdd:pfam00400  13 SVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH