|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
28-964 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 1369.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 28 MRANSVIREPEIHEFWSRNKIDLELGSTNSGKNFTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDC 107
Cdd:PLN02843 1 MRANSVTREPEIQKLWEENQVYKRVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 108 HGLPIELKVLQSLKSNERRNLDSLGLRKKATDYAKIQINNQLEGFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNG 187
Cdd:PLN02843 81 HGLPIELKVLQSLDQEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 188 YIYRGLKPVHWSPSSRTALAEAELEYPEEHFSKSIYVSLNITKLSDAVLLKLEEKdlrnkllssLNKLFIAIWTTTPWTI 267
Cdd:PLN02843 161 YIYRGRKPVHWSPSSRTALAEAELEYPEGHVSKSIYVAFPVVSPSETSPEELEEF---------LPGLSLAIWTTTPWTM 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 268 PGNEAVAINPRINYVF------------------------ASDQNGNIYLFARDLISEICEKLDREFNVLLDVKGSLLEG 323
Cdd:PLN02843 232 PANAAVAVNDKLQYSVvevqsfsedestsggnkkkrpgnvLKEQQKLFLIVATDLVPALEAKWGVKLVVLKTFPGSDLEG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 324 LEYKHPTKNKFCNIVIGGDYITTESGTGIVHTAPGHGMDDFNVGQKYQLPITCIVDEKGNLNKHAEKFCGLNVLKDANDL 403
Cdd:PLN02843 312 CRYIHPLYNRESPVVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLGEGNAA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 404 IIEDLEKNNLLLLKENYKHRYPYDWRTKKPTIFRATEQWFASVEGFRSSALKAIEDVEWMPKTGKKRIYSMVVGRGDWCI 483
Cdd:PLN02843 392 VVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQGENRIRAMVSGRSDWCI 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 484 SRQRSWGVPIPVFYEKEGKGVLINTETINHIKSLFEEYGADVWWEWDEKKLLPEKYRNESDRWEKGLDTMDVWFDSGSSW 563
Cdd:PLN02843 472 SRQRTWGVPIPVFYHVETKEPLMNEETIAHVKSIVAQKGSDAWWYMDVEDLLPEKYRDKASDYEKGTDTMDVWFDSGSSW 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 564 AAVCEQREELQYPADLYLEGSDQHRGWFQSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIINGGPN 643
Cdd:PLN02843 552 AGVLGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEGGKN 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 644 QKIQPAYGADVLRLWVSSVDYSVDVPIGSNILKQLSDVYRKVRNTARYLLGNIHDYDPAlEEIDIDQLPLLDQWMLNRLV 723
Cdd:PLN02843 632 QKQEPAYGADVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKPD-NAVPYEDLPSIDKYALFQLE 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 724 EVSDEVTIAYENYEFSKFFQILQSFCVVDLSNFYLDIAKDRLYVSAKTQFRRRSCQFVMSRIVENLAVIISPVLCHMAED 803
Cdd:PLN02843 711 NVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAED 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 804 IWQNIPYS---TIEKSVFERRWPKFPESWLN--PELNEHISNLRTLRVEINKAIEGCRTQQMIGAALETEVNYLPENEFF 878
Cdd:PLN02843 791 AWQNLPFQedgSAAESVFEAGWPTPNEEWLSfpAEDVDFWSLLLEVRDEVNKVLESARNGKLIGASLEAKVYLHASDASL 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 879 KNSLSWLDKFGNkEVDLYRDWLIVSDFNIVNNLSKDCLSIDNNELGKIQ--------ILKAKGLKCDRCWHYQNITVKGI 950
Cdd:PLN02843 871 AARLAELCGASN-GADELRRIFITSQVEVVSSEDDETAACGSYTGEYVEgagrvwvgVSRADGSKCERCWNYSPAVGSFS 949
|
970
....*....|....
gi 81576445 951 ENTKLCERCANIIN 964
Cdd:PLN02843 950 DHPTLCERCYPVVI 963
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
15-963 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1241.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 15 YKETLNLLKTDFSMRANSVIREPEIHEFWSRNKIDLELGSTNSGKN-FTLHDGPPYANGSLHMGHALNKVLKDIINKYKT 93
Cdd:COG0060 1 YKETLNLPKTDFPMRANLPKREPEILKFWEENDIYEKSREARAGRPkFVLHDGPPYANGDIHIGHALNKILKDIIVRYKT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 94 LQGFKVHFIPGWDCHGLPIELKVLQSLKSNeRRNLDSLG---LRKKATDYAKIQINNQLEGFKRWGIWGDWDNPYLTLKK 170
Cdd:COG0060 81 MRGFDVPYVPGWDCHGLPIELKVEKELGIK-KKDIEKVGiaeFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 171 NYESAQIGVFGKMFLNGYIYRGLKPVHWSPSSRTALAEAELEYpEEHFSKSIYVSLnitKLSDAVLLKLEEKdlrnklls 250
Cdd:COG0060 160 EYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEY-KDVTSPSIYVKF---PVKDEKALLLLED-------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 251 slnkLFIAIWTTTPWTIPGNEAVAINPRINYVFASDQNGNIYLFARDLISEICEKLDRE-FNVLLDVKGSLLEGLEYKHP 329
Cdd:COG0060 228 ----AYLVIWTTTPWTLPANLAVAVHPDIDYVLVEVTGGERLILAEALVEAVLKELGIEdYEVLATFKGAELEGLRYEHP 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 330 ----TKNKFCNIVIGGDYITTESGTGIVHTAPGHGMDDFNVGQKYQLPITCIVDEKGNLNKHAEKFCGLNVlKDANDLII 405
Cdd:COG0060 304 fyyvVGYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFV-KDANPAII 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 406 EDLEKNNLLLLKENYKHRYPYDWRTKKPTIFRATEQWFASVEGFRSSALKAIEDVEWMPKTGKKRIYSMVVGRGDWCISR 485
Cdd:COG0060 383 EDLKERGALLAREKITHSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEWGEGRFGNMLENRPDWCISR 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 486 QRSWGVPIPVFYEKEGKGVLINTETINHIKSLFEEYGADVWWEWD-EKKLLPEKYRNES--DRWEKGLDTMDVWFDSGSS 562
Cdd:COG0060 463 QRYWGVPIPIWVCEDCGELHRTEEVIGSVAELLEEEGADAWFELDlHRPFLDETLKCPKcgGTMRRVPDVLDVWFDSGSM 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 563 WAAVCEQREELQYPADLYLEGSDQHRGWFQSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIINggp 642
Cdd:COG0060 543 HFAVLENREELHFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVID--- 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 643 nqkiqpAYGADVLRLWVSSVDYSVDVPIGSNILKQLSDVYRKVRNTARYLLGNIHDYDPALEEIDIDQLPLLDQWMLNRL 722
Cdd:COG0060 620 ------KYGADILRLWVASSDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLANLDDFDPAEDAVPYEDLPELDRWILSRL 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 723 VEVSDEVTIAYENYEFSKFFQILQSFCVVDLSNFYLDIAKDRLYVSAKTQFRRRSCQFVMSRIVENLAVIISPVLCHMAE 802
Cdd:COG0060 694 NELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAE 773
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 803 DIWQNIPYSTiEKSVFERRWPKFPESWLNPELNEHISNLRTLRVEINKAIEGCRTQQMIGAALETEVNYLPENEFFKnsl 882
Cdd:COG0060 774 EIWQNLPGEA-EESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLKALEAARKEKLIRQPLEAAVVLYADEELAA--- 849
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 883 sWLDKFGnkevDLYRDWLIVSDFNIVNNLS---KDCL-SIDNNELG-KIQILKAKGLKCDRCWHYqniTVkGI--ENTKL 955
Cdd:COG0060 850 -ALESLG----DLLAEELNVSEVELVDDAEdlgKDALkALDVEGISvTVEVEKADGEKCERCWHY---EV-GWtpEHEGL 920
|
....*...
gi 81576445 956 CERCANII 963
Cdd:COG0060 921 CRRCVRRV 928
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
25-870 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 937.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 25 DFSMRANSVIREPEIHEFWSRNKIDLELGSTNSGKN-FTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIP 103
Cdd:TIGR00392 1 KFPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPeFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 104 GWDCHGLPIELKVLQSLKSNERRNLDSLGL---RKKATDYAKIQINNQLEGFKRWGIWGDWDNPYLTLKKNYESAQIGVF 180
Cdd:TIGR00392 81 GWDTHGLPIEHKVEKKLGISGKKEISSLEIeefREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 181 GKMFLNGYIYRGLKPVHWSPSSRTALAEAELEYPE---EHFSKSIYVSLNITKlsdavllklEEKDLRNKLLSSLnklfi 257
Cdd:TIGR00392 161 KEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKEnykDVKDPSIYVKFPVKK---------DKKTYLKVKLSSL----- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 258 AIWTTTPWTIPGNEAVAINPRINYVFASDQNGNIYL-FARDLISEICEKLDREFNVLLDVKGSLLEGLEYKHP------T 330
Cdd:TIGR00392 227 LIWTTTPWTLPSNLAIAVHPDFEYALVQDNTKVEYFiLAKKLVEKLYNKAGSDYEIIKTFKGSDLEGLEYEHPlydfvsQ 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 331 KNKFCNIVIGGDYITTESGTGIVHTAPGHGMDDFNVGQKYQLPITCIVDEKGNLNKHAEKFCGLNV------LKDANDLI 404
Cdd:TIGR00392 307 LKEGAPVVIGGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGRFVkdadkdIIKANKII 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 405 IEDLEKNNLLLLKENYKHRYPYDWRTKKPTIFRATEQWFASVEGFRSSALKAIEDVEWMPKTGKKRIYSMVVGRGDWCIS 484
Cdd:TIGR00392 387 IEQLKDKGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGEGRFGNWLENRPDWCIS 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 485 RQRSWGVPIPVFYEKEGkGVLINTETINHIKSLFEEYGADVWWEWDEKKLLPEKYRN--ESDRWEKGLDTMDVWFDSGSS 562
Cdd:TIGR00392 467 RQRYWGIPIPIWYCEDT-GEPIVVGSIEELIELIELKGIDAWFEDLHRDFLDKITLKsgDGGEYRRVPDVLDVWFDSGSM 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 563 WAAVCEQREE-----LQYPADLYLEGSDQHRGWFQSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNII 637
Cdd:TIGR00392 546 PYASIHYPFEnekfkEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKV 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 638 INggpnqkiqpAYGADVLRLWVSSVDYSVDVPIGSNILKQLSDVYRKVR-NTARYLL--GNIHDYDPALEEIDIDQLPLL 714
Cdd:TIGR00392 626 IN---------KYGADILRLYVASSDPWEDLRFSDEILKQVVEKYRKIRwNTYRFLLtyANLDKFDPLFNSVAVEKFPEE 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 715 DQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFCVVDLSNFYLDIAKDRLYVSAKTQfRRRSCQFVMSRIVENLAVIIS 794
Cdd:TIGR00392 697 DRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELSNWYIRIIRDRLYCEAKDN-DKRAAQTTLYYALLTLVRLLA 775
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 795 PVLCHMAEDIWQNIPYSTIEKSVFERRWPKFPESWLNPEL-------NEHISNLRTLRVEINKAIEGCRTQQMIGAALET 867
Cdd:TIGR00392 776 PFLPHTAEEIYQNLPGGEEEESVHLNLWPEVDEEFIDEALeanmaivREIVEAFLALRDAANKKLRQPLKELVIGKSLEA 855
|
...
gi 81576445 868 EVN 870
Cdd:TIGR00392 856 VLK 858
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
39-670 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 623.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 39 IHEFWsrNKIDL---ELGSTNSGKNFTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELK 115
Cdd:pfam00133 2 IYEFW--DEQGYfkpELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 116 VLQSLKSNERRNLDSLGL---RKKATDYAKIQINNQLEGFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRG 192
Cdd:pfam00133 80 VEKKLGIKEKKTRHKYGReefREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 193 LKPVHWSPSSRTALAEAELEYPEEHfSKSIYVSLNitklsdavllkLEEKDlrnkllsslnKLFIAIWTTTPWTIPGNEA 272
Cdd:pfam00133 160 KKLVNWSPALNTALSNLEVEYKDVK-GPSIHVAFP-----------LADDE----------GASLVIWTTTPWTLPGNTA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 273 VAINPRINYVfasdQNGNIYLFARDLISEICEKLDrEFNVLLDVKGSLLEGLEYKHPTKNkFCNIVIGGDYITTESGTGI 352
Cdd:pfam00133 218 VAVNPEFDYV----ITGEGYILAEALLKSLYKKGT-DKKILEDFRGKELEGKEAIHPFVN-REIPIITDDYVDMEFGTGA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 353 VHTAPGHGMDDFNVGQKYQLPITCIVDEKGNLNKHAEKFCGLNVlKDANDLIIEDLEKNNLLLLKENYKHRYPYDWRTKK 432
Cdd:pfam00133 292 VHIAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYR-FDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGT 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 433 PTIFRATEQWFASVEGFRSSALKAIEDVEWMPKTGKKRIYSMVVGRGDWCISRQRSWGVPIPVFYEKEGKGVLINTETIN 512
Cdd:pfam00133 371 PIIPRATPQWFVRMDELADQALEAVEKVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFE 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 513 HIKSLFEEYGADVWWEWDEKKLLpekyRNESDRWEKGLDTMDVWFDSGSSWAAV----CEQREELQ--YPADLYLEGSDQ 586
Cdd:pfam00133 451 LVAGRFEEEGSIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTlgwpFVNTEEFKkfFPADMLLEGSDQ 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 587 HRGWFQSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIINggpnqkiqpAYGADVLRLWVSSVDYSV 666
Cdd:pfam00133 527 TRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID---------KYGADALRLWLANSDYGR 597
|
....
gi 81576445 667 DVPI 670
Cdd:pfam00133 598 DINL 601
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
36-932 |
1.15e-125 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 402.13 E-value: 1.15e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 36 EPEIHEFWSRNKIdLELGSTNSGKNFTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELK 115
Cdd:TIGR00422 11 EKKWYKKWEKSGF-FKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIATQVK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 116 VLQSLKS--NERRNLDSLGLRKKATDYAKIQINNQLEGFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGL 193
Cdd:TIGR00422 90 VEKKLGAegKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLIYRGE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 194 KPVHWSPSSRTALAEAELEYpeehfsKSIYVSLNITKLsdavllKLEEKDlrnkllsslnKLFIAIWTTTPWTIPGNEAV 273
Cdd:TIGR00422 170 YLVNWDPKLNTAISDIEVEY------KEVKGKLYYIRY------PLANGS----------KDYLVVATTRPETMFGDTAV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 274 AINPRinyvfasdqngniylfardliseicekldrefnvllDVKGSLLEGLEYKHPTKNKFCNIvIGGDYITTESGTGIV 353
Cdd:TIGR00422 228 AVHPE------------------------------------DERYKHLIGKKVILPLTGRKIPI-IADEYVDMEFGTGAV 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 354 HTAPGHGMDDFNVGQKYQLPITCIVDEKGNLNKHAEKFCGLNVLkDANDLIIEDLEKNNLLLLKENYKHRYPYDWRTKKP 433
Cdd:TIGR00422 271 KVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRF-EARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTV 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 434 TIFRATEQWFASVEGFRSSALKAIED--VEWMPKTGKKRIYSMVVGRGDWCISRQRSWGVPIPVFYEKEGKGVLINTEti 511
Cdd:TIGR00422 350 VEPLLSKQWFVKVEKLADKALEAAEEgeIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEVYVAKE-- 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 512 nhikslfeeygadvwwEWDEKKllpEKYRNESDRWEKGLDTMDVWFDSgSSWAAVC----EQREELQ--YPADLYLEGSD 585
Cdd:TIGR00422 428 ----------------EPLPDD---KTNTGPSVELEQDTDVLDTWFSS-SLWPFSTlgwpDETKDLKkfYPTDLLVTGYD 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 586 QHRGWFQSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIINggpnqkiqpAYGADVLRLWVSSvdys 665
Cdd:TIGR00422 488 IIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIE---------KYGADALRFTLAS---- 554
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 666 vDVPIGSNILKQLSDV------YRKVRNTARYLLGNIHDyDPALEEiDIDQLPLLDQWMLNRLVEVSDEVTIAYENYEFS 739
Cdd:TIGR00422 555 -LVTPGDDINFDWKRVesarnfLNKLWNASRFVLMNLSD-DLELSG-GEEKLSLADRWILSKLNRTIKEVRKALDKYRFA 631
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 740 KFFQILQSFCVVDLSNFYLDIAKDRLYvsAKTQFRRRSCQFVMSRIVENLAVIISPVLCHMAEDIWQNIPYSTieKSVFE 819
Cdd:TIGR00422 632 EAAKALYEFIWNDFCDWYIELVKYRLY--NGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGA--DSIML 707
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 820 RRWPKFPESWLNPE-------LNEHISNLRTLRVEINKAIEGCRTQQMIGAALETEVNYLPENEFFKN--SLSWLDKFGN 890
Cdd:TIGR00422 708 QSYPVVDAEFVDEEaekafelLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGaiNFSEVEVVIE 787
|
890 900 910 920
....*....|....*....|....*....|....*....|..
gi 81576445 891 KEVDLYRDWLIVSDFNIVNNLSKdcLSIDNNELGKIQILKAK 932
Cdd:TIGR00422 788 KPEVTEAVVELVPGFEIIIPVKG--LINKAKELARLQKQLDK 827
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
67-852 |
1.93e-106 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 349.11 E-value: 1.93e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 67 PPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVLQSLKSN----ERRNLdsLGLRKKATDYAK 142
Cdd:PRK13208 46 PPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDNGLPTERKVEKYYGIRkddiSREEF--IELCRELTDEDE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 143 IQINNQlegFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGLKPVHWSPSSRTALAEAELEYPEEHfskSI 222
Cdd:PRK13208 124 KKFREL---WRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYRERE---GK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 223 YVSLNitklsdavlLKLEEKDlrnkllsslnKLFIAiwTTTPWTIPGNEAVAINPrinyvfasDQNGNIYLFARDLISEI 302
Cdd:PRK13208 198 LNYIK---------FPVEDGE----------EIEIA--TTRPELLPACVAVVVHP--------DDERYKHLVGKTAIVPL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 303 cekldreFNVllDVKgsllegleykhptknkfcniVIGGDYITTESGTGIVhtapghgM-----D--DFNVGQKYQLPIT 375
Cdd:PRK13208 249 -------FGV--EVP--------------------ILADPLVDPDFGTGAV-------MictfgDktDVTWWRELNLPTR 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 376 CIVDEKGNLNKHAEKFCGLNVlKDANDLIIEDLEKNNLLLLKENYKHRYPYDWRTKKPTIFRATEQWFASVEGFRSSALK 455
Cdd:PRK13208 293 IIIDEDGRMTEAAGKLAGLTI-EEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLE 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 456 AIEDVEWMPKTGKKR----IYSMvvgRGDWCISRQRSWGVPIPVFY-EKEGKgVLINTEtinhikslfEEYGADVWwewd 530
Cdd:PRK13208 372 RGKEINWYPEHMRVRlenwIEGL---NWDWCISRQRYFGTPIPVWYcKDCGH-PILPDE---------EDLPVDPT---- 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 531 ekKLLPEKYRNE---SDRWEKGLDTMDVWFDSGSSWAAVC-----EQREELQYPADLYLEGSDQHRGWFQSSLLTSVAVN 602
Cdd:PRK13208 435 --KDEPPGYKCPqcgSPGFEGETDVMDTWATSSITPLIVTgwerdEDLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLT 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 603 NKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIINggpnqkiqpAYGADVLRLWVSSVDYSVDVPIGSNILKQLSDVY 682
Cdd:PRK13208 513 GKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLE---------KYGADAVRYWAASARLGSDTPFDEKQVKIGRRLL 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 683 RKVRNTARYLLGNIHDYDPALEEIdidqLPLLDQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFCVVDLSNFYLDIAK 762
Cdd:PRK13208 584 TKLWNASRFVLHFSADPEPDKAEV----LEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVK 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 763 DRLYvSAKTQFRRRSCQFVMSRIVENLAVIISPVLCHMAEDIWQNIPystiEKSVFERRWPKFPESWLNPELNEHISNLr 842
Cdd:PRK13208 660 SRAY-GEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLY----GGSVHRASWPEPDEELIDEEDEELGELA- 733
|
810
....*....|
gi 81576445 843 tlrVEINKAI 852
Cdd:PRK13208 734 ---KEILSAV 740
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
25-852 |
2.76e-99 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 337.47 E-value: 2.76e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 25 DFSMRAnsviREPEIHEFWSRNK-IDLELGSTNSGKNFTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIP 103
Cdd:PLN02882 7 DFSFPK----QEEKILSLWSEIDaFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 104 GWDCHGLPIELKVLQSLKSNERRNLDSLGL-------RKKATDYAKiqinnQLEG-FKRWGIWGDWDNPYLTLKKNYESA 175
Cdd:PLN02882 83 GWDCHGLPVEYEIDKKLGIKRRDDVLKMGIdkyneecRSIVTRYSK-----EWEKtVTRTGRWIDFENDYKTMDPKFMES 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 176 QIGVFGKMFLNGYIYRGLKPVHWSPSSRTALA--EAELEYPEEHfSKSIYVSLNItkLSDAvllkleekdlrnkllssLN 253
Cdd:PLN02882 158 VWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSnfEAGLNYKDVS-DPAVMVSFPI--VGDP-----------------DN 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 254 KLFIAiWTTTPWTIPGNEAVAINPRINYVFASDQ-NGNIYLFARDLISEI------------CEKLDREFNVLLDVKGSL 320
Cdd:PLN02882 218 ASFVA-WTTTPWTLPSNLALCVNPNFTYVKVRNKyTGKVYIVAESRLSALptakpkskkgskPENAAEGYEVLAKVPGSS 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 321 LEGLEYKhPTKNKFCNI------VIGGDYITTESGTGIVHTAPGHGMDDFNVGQKYQ-------LPitCIVDEKGNLNKH 387
Cdd:PLN02882 297 LVGKKYE-PLFDYFSEFsdtafrVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGiiekggnLP--VPVDDDGCFTEK 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 388 AEKFCGLNVlKDANDLIIEDLEKNNLLLLKENYKHRYPYDWRTKKPTIFRATEQWFASVEGFRSSALKAIEDVEWMPKTG 467
Cdd:PLN02882 374 VTDFSGRYV-KDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYV 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 468 K-KRIYSMVVGRGDWCISRQRSWGVPIPVFYEKEGKGVLIntetINHIKSLFEEYGA---DVWWEWDEKKLLPEKYRNES 543
Cdd:PLN02882 453 KeKRFHNWLENARDWAVSRSRFWGTPLPIWISDDGEEVVV----IGSIAELEKLSGVkvtDLHRHFIDHITIPSSRGPEF 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 544 DRWEKGLDTMDVWFDSGSSWAAVC----EQRE--ELQYPADLYLEGSDQHRGWFQSSLLTSVAVNNKPPYKTVLTHGFAL 617
Cdd:PLN02882 529 GVLRRVDDVFDCWFESGSMPYAYIhypfENKElfEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVL 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 618 DENGRKMSKSLGNVVDPNIIINggpnqkiqpAYGADVLRLwvssvdYSVDVPI---------GSNILKQLSDVYRKVRNT 688
Cdd:PLN02882 609 AEDGKKMSKSLKNYPDPNEVID---------KYGADALRL------YLINSPVvraeplrfkEEGVFGVVKDVFLPWYNA 673
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 689 ARYLLGNI--------HDYDPaleeIDIDQLP----LLDQWML---NRLVEVSDEVTIAYENYEFSKFfqiLQSFcVVDL 753
Cdd:PLN02882 674 YRFLVQNAkrleveggAPFVP----LDLAKLQnsanVLDRWINsatQSLVKFVREEMGAYRLYTVVPY---LVKF-IDNL 745
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 754 SNFYLDIAKDRLyvsaKTQFRRRSCQFVMSRIVE---NLAVIISPVLCHMAEDIWQNI--PYSTIEKSVFERRWPKFPES 828
Cdd:PLN02882 746 TNIYVRFNRKRL----KGRTGEEDCRTALSTLYNvllTSCKVMAPFTPFFTEVLYQNLrkVLPGSEESIHYCSFPQVDEG 821
|
890 900
....*....|....*....|....
gi 81576445 829 WLNPELNEHISNLRTLrVEINKAI 852
Cdd:PLN02882 822 ELDERIEQSVSRMQTV-IELARNI 844
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
420-663 |
5.13e-88 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 284.89 E-value: 5.13e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 420 YKHRYPYDWrtkkPTIFRATEQWFASVEGFRSSALKAIEDVEWMPKTGKKRIYSMVVGRGDWCISRQRSWGVPIPVFYEK 499
Cdd:cd00818 135 YRGYKVVPW----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCE 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 500 EGKGVLIntetinhikslfeeygadvwwewdekkllpekyrnesdrwEKGLDTMDVWFDSGSSWAAV-----CEQREELQ 574
Cdd:cd00818 211 DCGEVLV----------------------------------------RRVPDVLDVWFDSGSMPYAQlhypfENEDFEEL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 575 YPADLYLEGSDQHRGWFQSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIInggpnqkiqPAYGADV 654
Cdd:cd00818 251 FPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV---------DKYGADA 321
|
....*....
gi 81576445 655 LRLWVSSVD 663
Cdd:cd00818 322 LRLWVASSD 330
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
36-849 |
3.78e-87 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 298.56 E-value: 3.78e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 36 EPEIHEFWSRN---KIDlelgsTNSGKNFTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDcH-GLP 111
Cdd:PRK05729 15 EAKWYQKWEEKgyfKPD-----DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTD-HaGIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 112 IELKVLQSLKSNERRNLDsLG----LRK----KATdYAKIqINNQLegfKRWGIWGDWDNPYLTLKKNYESAQIGVFGKM 183
Cdd:PRK05729 89 TQMVVERQLAAEGKSRHD-LGrekfLEKvwewKEE-SGGT-ITNQL---RRLGASCDWSRERFTMDEGLSKAVREVFVRL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 184 FLNGYIYRGLKPVHWSPSSRTALAEAELEYPEE-----HFSksiYvslnitKLSDavllkleEKDlrnkllsslnklFIA 258
Cdd:PRK05729 163 YEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVkgklwHIR---Y------PLAD-------GSD------------YLV 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 259 IWTTTPWTIPGNEAVAINP---RinyvfasdqngniYlfaRDLIseicekldrefnvlldvkgslleGLEYKHPtknkFC 335
Cdd:PRK05729 215 VATTRPETMLGDTAVAVNPedeR-------------Y---KHLI-----------------------GKTVILP----LV 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 336 N--I-VIGGDYITTESGTGIVHTAPGHGMDDFNVGQKYQLPITCIVDEKGNLNKHAEKFCGLNVLkDANDLIIEDLEKNN 412
Cdd:PRK05729 252 GreIpIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEYQGLDRF-EARKAIVADLEELG 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 413 LLLLKENYKHRYPYDWRTKKPTIFRATEQWFASVEGFRSSALKAIE--DVEWMPKTGKKRIYSMVVGRGDWCISRQRSWG 490
Cdd:PRK05729 331 LLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVEngEIKFVPERWEKTYFHWMENIQDWCISRQLWWG 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 491 VPIPVFYEKEGKGVLINTEtinhikslfEEYGADVWWEWDEkkllpekyrnesdrwekglDTMDVWFDSG----SS--WA 564
Cdd:PRK05729 411 HRIPAWYDEDGEVYVGREE---------PEAREKALLTQDE-------------------DVLDTWFSSAlwpfSTlgWP 462
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 565 avcEQREELQ--YPADLYLEGSDqhrgW-----FQSSLLTsvavnNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNII 637
Cdd:PRK05729 463 ---EKTEDLKrfYPTSVLVTGFDiiffWvarmiMMGLHFT-----GQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDL 534
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 638 INggpnqkiqpAYGADVLRLWVSSVdySV---DVPIGSNILKQlsdvYR----KVRNTARYLLGNIHDYDPAlEEIDIDQ 710
Cdd:PRK05729 535 ID---------KYGADALRFTLAAL--ASpgrDIRFDEERVEG----YRnfanKLWNASRFVLMNLEGADVG-ELPDPEE 598
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 711 LPLLDQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFCVVDLSNFYLDIAKDRLYVSAKtqfrrRSCQFVMSRIVENLA 790
Cdd:PRK05729 599 LSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQEAAK-----RATRATLAYVLEQIL 673
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81576445 791 VIISPVLCHMAEDIWQNIPYSTIEKSVFERRWPKFPESwLNPELNEH-------ISNLRTLRVEIN 849
Cdd:PRK05729 674 RLLHPFMPFITEELWQKLAPLGIEESIMLAPWPEADEA-IDEAAEAEfewlkelITAIRNIRAEMN 738
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
670-849 |
6.15e-84 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 267.85 E-value: 6.15e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 670 IGSNILKQLSDVYRKVRNTARYLLGNIHDYDPALEEIDIDQLPLLDQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFC 749
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 750 VVDLSNFYLDIAKDRLYVSAKTQFRRRSCQFVMSRIVENLAVIISPVLCHMAEDIWQNIPYSTIEKSVFERRWPKFPESW 829
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEESVFLEDWPELPEEW 160
|
170 180
....*....|....*....|
gi 81576445 830 LNPELNEHISNLRTLRVEIN 849
Cdd:cd07960 161 KDEELEEKWEKLLALRDEVN 180
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
67-849 |
3.05e-79 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 276.55 E-value: 3.05e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 67 PPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDcH-GLPIELKVLQSLKSN--ERRNLDslglRKKATDYA-- 141
Cdd:COG0525 43 PPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD-HaGIATQAVVERQLAEEgkSRHDLG----REKFLERVwe 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 142 -KIQ----INNQLegfKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGLKPVHWSPSSRTALAEAELEYPEE 216
Cdd:COG0525 118 wKEEsggtITNQL---RRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEV 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 217 -----HFSksiYvslnitKLSDavllkleEKDlrnkllsslnklFIAIWTTTPWTIPGNEAVAINPrinyvfaSDqngni 291
Cdd:COG0525 195 kghlwHIR---Y------PLAD-------GSG------------YIVVATTRPETMLGDTAVAVHP-------ED----- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 292 ylfardliseiceklDRefnvlldvkgsllegleYKHpTKNKFCNI--------VIGGDYITTESGTGIVHTAPGHGMDD 363
Cdd:COG0525 235 ---------------ER-----------------YKH-LIGKTVILplvgreipIIADEYVDPEFGTGAVKITPAHDPND 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 364 FNVGQKYQLPITCIVDEKGNLNKHAEKFCGL-------NVLKD--ANDLI--IEDleknnllllkenYKHRYPYDWRTKK 432
Cdd:COG0525 282 FEVGKRHNLPMINILDEDGTINENAGKYRGLdrfearkAIVADleELGLLvkVEP------------HKHSVGHSDRSGT 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 433 PTIFRATEQWFASVEGFRSSALKAIED--VEWMPKTGKKRIYSMVVGRGDWCISRQRSWGVPIPVFYEKEGKGVLINTEt 510
Cdd:COG0525 350 VIEPYLSDQWFVKMKPLAKPAIEAVEDgeIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCPDGEVYVARTE- 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 511 inhikslfEEygadvwwewDEKKLLPEKYRNESDRwekgLDTmdvWFDSG----SS--WAavcEQREELQ--YPADLyle 582
Cdd:COG0525 429 --------PE---------ACAKAGSVNLTQDEDV----LDT---WFSSAlwpfSTlgWP---EKTEDLKyfYPTSV--- 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 583 gsdqhrgwfqssLLTS-------VA--------VNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIINggpnqkiq 647
Cdd:COG0525 479 ------------LVTGfdiiffwVArmimmglhFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLID-------- 538
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 648 pAYGADVLRL-WVSSVDYSVDVPIGSNILKQlsdvYR----KVRNTARYLLGNIHDYDPALEEiDIDQLPLLDQWMLNRL 722
Cdd:COG0525 539 -KYGADALRFtLAALASPGRDIKFDEERVEG----YRnfanKLWNASRFVLMNLEGFDPGLDP-DPEELSLADRWILSRL 612
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 723 VEVSDEVTIAYENYEFSKFFQILQSFcvV--DLSNFYLDIAKDRLYvsAKTQFRRRSCQFVMSRIVENLAVIISPVLCHM 800
Cdd:COG0525 613 NKTIAEVTEALEKYRFDEAAQALYDF--VwnEFCDWYLELAKPRLY--GGDEAAKRETRATLVYVLEQILRLLHPFMPFI 688
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 81576445 801 AEDIWQNIPYSTIEKSVFERRWPKFPESWLNPELNEH-------ISNLRTLRVEIN 849
Cdd:COG0525 689 TEEIWQKLPPRKEGESIMLAPWPEADEELIDEEAEAEfewlkevISAIRNIRAEMN 744
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
17-808 |
4.14e-78 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 278.00 E-value: 4.14e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 17 ETLNLLKTDFSMRANSVIREPEIHEFW-SRNKIDLELGSTNSGKNFTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQ 95
Cdd:PTZ00427 59 EMVTVTFTGVSENPNIVEEEEKVLKYWkSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQC 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 96 GFKVHFIPGWDCHGLPIELKVLQSLKSNERRNLDSLGL-------RKKATDYAkiqiNNQLEGFKRWGIWGDWDNPYLTL 168
Cdd:PTZ00427 139 GFSVERKFGWDCHGLPIEYEIEKENNINKKEDILKMGIdvynekcRGIVLKYS----NEWVKTVERIGRWIDFKNDYKTM 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 169 KKNYESAQIGVFGKMFLNGYIYRGLKPVHWSPSSRTALAEAELEYP-EEHFSKSIYVSL----------NITKLSDAVLL 237
Cdd:PTZ00427 215 DKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNyKDTPDPSIIISFvlcsdfpkveEECNIEEDKQL 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 238 KLE----------EKDLRNKLLSSLNKLF-----IAIWTTTPWTIPGNEAVAINPRINYVFASDQNGN-IYLFARDLISE 301
Cdd:PTZ00427 295 LGEkysvlynnkrENSNNGNNNSTNNVCYaqhseILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSNrVVIVGECRLEW 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 302 ICEKLD---REFNVLLDVKGSLLEGLEYKhPTKNKFCNI---------VIGGDYITTESGTGIVHTAPGHGMDDFNVGQK 369
Cdd:PTZ00427 375 IMKELKwnvEDLKIVNRFKGKELKGLRYK-PLFTNFYEKynfkeraykILADDFVTDDAGTGIVHCAPTYGEDDFRVCKK 453
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 370 YQL--PITCI----VDEKGNLNKHAEKFCGLnVLKDANDLIIEDLEKNNLLLLKENYKHRYPYDWRTKKPTIFRATEQWF 443
Cdd:PTZ00427 454 NGVidPEKNIfidpLDANGYFTNEVEEVQNL-YIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWF 532
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 444 ASVEGFRSSALKAIEDVEWMPKTGK-KRIYSMVVGRGDWCISRQRSWGVPIPVFYEKEGKGVlINTETINH--------- 513
Cdd:PTZ00427 533 IRVSNSTNELVKNNETTYWIPAHIKeKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETV-ICVESIKHleelsgvkn 611
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 514 IKSLFEEYGADVWWEWDEKKLLPEKYRNEsdrwekglDTMDVWFDSGS-SWAAV----CEQREELQ--YPADLYLEGSDQ 586
Cdd:PTZ00427 612 INDLHRHFIDHIEIKNPKGKTYPKLKRIP--------EVFDCWFESGSmPYAKVhypfSTEKEDFHkiFPADFIAEGLDQ 683
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 587 HRGWFQSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIINggpnqkiqpAYGADVLRLW-VSSV--- 662
Cdd:PTZ00427 684 TRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILD---------KYGADSLRLYlINSVavr 754
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 663 -------DYSVDVPIGSNILKQL-------SDVYR-KVRNTARYLLGNIHDYDPAleeididqlPLLDQWMLNRLVEVSD 727
Cdd:PTZ00427 755 aenlkfqEKGVNEVVKSFILPFYhsfrffsQEVTRyECLNKKQFLFNTDYIYKND---------NIMDQWIFSSVQSLTK 825
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 728 EVTIAYENYEFSKFFQILQSFcVVDLSNFYLDIAKDRLYVSAKTQFRRRSCQfVMSRIVENLAVIISPVLCHMAEDIWQN 807
Cdd:PTZ00427 826 SVHTEMKAYKLYNVLPKLLQF-IENLTNWYIRLNRDRMRGSLGEENCLQSLC-TTYRTLHLFTVLMAPFTPFITEYIYQQ 903
|
.
gi 81576445 808 I 808
Cdd:PTZ00427 904 L 904
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
41-924 |
7.74e-68 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 245.69 E-value: 7.74e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 41 EFWSRNKI---DLELGSTNSGKNFTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVL 117
Cdd:PTZ00419 39 EWWEKSGFfkpAEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 118 QSLKSNERRNLDSLG---LRKKATDYAKI---QINNQLegfKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYR 191
Cdd:PTZ00419 119 KKLMKEENKTRHDLGreeFLKKVWEWKDKhgnNICNQL---RRLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 192 GLKPVHWSPSSRTALAEAELEYPE---------EHFSKSIYVSlNITKLSdavlLKLEEKDLRnkllsslnKLFIAiwTT 262
Cdd:PTZ00419 196 DTRLVNWCCYLKTAISDIEVEFEEiekptkitiPGYDKKVEVG-VLWHFA----YPLEDSGQE--------EIVVA--TT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 263 TPWTIPGNEAVAINPrinyvfasdqNGNIYlfaRDLIseicekldrefnvlldvkgslleGLEYKHPTKNKFCNIVIGGD 342
Cdd:PTZ00419 261 RIETMLGDVAVAVHP----------KDERY---KKLH-----------------------GKELIHPFIPDRKIPIIADD 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 343 -YITTESGTGIVHTAPGHGMDDFNVGQKYQLPITCIVDEKGNLNKHAEKFCGLNVLkDANDLIIEDLEKNNLLLLKENYK 421
Cdd:PTZ00419 305 eLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRF-DCRRKIEEELKEMGLLRDKVPNP 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 422 HRYPYDWRTKKPTIFRATEQWFASVEGFrssALKAIEDVewmpKTGKKRIY--SMVV-------GRGDWCISRQRSWGVP 492
Cdd:PTZ00419 384 MRLPRCSRSGDIVEPMLIPQWYVNCKDM---AKRAVEAV----RNGELKIIpsSHENvwyhwleNIQDWCISRQLWWGHR 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 493 IPVfYEKEGKGVLINtetinhikslfeEYGADVW------WEWDEK-----KLLPEKYRNESDRwekglDTMDVWFDSG- 560
Cdd:PTZ00419 457 IPA-YRVISKGPETD------------PSDEEPWvvarseEEALEKakkkfGLSEEDFELEQDE-----DVLDTWFSSGl 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 561 ---SS--WAavcEQREELQ--YPADLYLEGSDQHRGWFQSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVD 633
Cdd:PTZ00419 519 fpfSTlgWP---DQTDDLQrfFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVID 595
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 634 PNIIING----GPNQKIQ------------------------PAYGADVLRLWVSSVDYSvdvpiGSNILKQLSDV--YR 683
Cdd:PTZ00419 596 PLEVIEGislqDLNQKLYegnlpekeikraielqkkefpngiPECGTDALRFGLLAYTQQ-----GRNINLDINRVvgYR 670
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 684 ----KVRNTARYLLGNIHDYDPALE-----EIDIDQLPLLDQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFCVVDLS 754
Cdd:PTZ00419 671 hfcnKLWNAVKFALMKLLKDFNLPNstlfkPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELC 750
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 755 NFYLDIAKDRLyVSAKTQFRRRSCQFVMSRIVENLAVIISPVLCHMAEDIWQNIP-YSTIEKSVFERRWPKFPESWLNPE 833
Cdd:PTZ00419 751 DVYLELIKPRL-SKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPnYLRKSESISIAKYPQPNPGWNNEA 829
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 834 LNEH-------ISNLRTLRV--EINKAIegcRTQQMIGAALETEVNYLPENEFFKNSLSwldKFGNKEVdlyrdwliVSD 904
Cdd:PTZ00419 830 LDEEmkiimsiVKSIRSLIAtlGIPNKT---KPDCYVTAKDAELIELIESAENLISTLA---KIGSVSV--------IPP 895
|
970 980
....*....|....*....|.
gi 81576445 905 FNIVNNLSKDCL-SIDNNELG 924
Cdd:PTZ00419 896 IEEEAEVPKGCGfDVVDNKVI 916
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
67-849 |
3.54e-67 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 244.52 E-value: 3.54e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 67 PPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVLQSLKSNERRNLDSLG---LRKKATDYaKI 143
Cdd:PRK14900 56 PPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIVEKELKKTEKKSRHDLGreaFLERVWAW-KE 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 144 QINNQL-EGFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGLKPVHWSPSSRTALAEAELEYPEEHfSKSI 222
Cdd:PRK14900 135 QYGSRIgEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAH-QGEL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 223 YvslnitklsdavllkleekDLRNKLLSSLNKLFIAiwTTTPWTIPGNEAVAINPrinyvfasdqngniylfardlisei 302
Cdd:PRK14900 214 W-------------------SFAYPLADGSGEIVVA--TTRPETMLGDTAVAVHP------------------------- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 303 cekldrefnvlLDVKGSLLEGLEYKHPTKNKFCNIVIGGDYITTESGTGIVHTAPGHGMDDFNVGQKYQLPITCIVDEKG 382
Cdd:PRK14900 248 -----------LDPRYMALHGKKVRHPITGRTFPIVADAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 383 NLNKHAEKFCGLNVL---KDANDLIIEDLEKNNLLllkenyKHRYPYDWRTKKPTIF--RATEQWFASVEGFRSSALKAI 457
Cdd:PRK14900 317 RMTAEAGPLAGLDRFearKEVKRLLAEQGLDRGAK------PHVLPLGRCQRSATILepLLSDQWYVRIEPLARPAIEAV 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 458 ED--VEWMPKTGKKRIYSMVVGRGDWCISRQRSWGVPIPVFYEKEGKgVLINTETinhikslfeeygadvwwewdekkll 535
Cdd:PRK14900 391 EQgrTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGH-VTVARET------------------------- 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 536 PEKYRNESDR-WEKGLDTMDVWFDSG------SSWAavcEQREELQ--YPADLYLEGSDQHRGWFQSSLLTSVAVNNKPP 606
Cdd:PRK14900 445 PEACSTCGKAeLRQDEDVLDTWFSSGlwpfstMGWP---EQTDTLRtfYPTSVMETGHDIIFFWVARMMMMGLHFMGEVP 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 607 YKTVLTHGFALDENGRKMSKSLGNVVDPNIIInggpnqkiqPAYGADVLRLWVSSVD-YSVDVPIGSNILKQLSDVYRKV 685
Cdd:PRK14900 522 FRTVYLHPMVRDEKGQKMSKTKGNVIDPLVIT---------EQYGADALRFTLAALTaQGRDIKLAKERIEGYRAFANKL 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 686 RNTARYLLGNIHDYdpALEEIDIDQLPLL--DQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFCVVDLSNFYLDIAKD 763
Cdd:PRK14900 593 WNASRFALMNLSGY--QERGEDPARLARTpaDRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKE 670
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 764 RLYvsAKTQFRRRSCQFVMSRIVENLAVIISPVLCHMAEDIWQNIPYS----TIEKSVFERRWPKF------PESWLNPE 833
Cdd:PRK14900 671 ALA--SEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQvgasAWADSVLAAEYPRKgeadeaAEAAFRPV 748
|
810
....*....|....*.
gi 81576445 834 LNEhISNLRTLRVEIN 849
Cdd:PRK14900 749 LGI-IDAVRNIRGEMG 763
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
61-198 |
5.50e-66 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 225.19 E-value: 5.50e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 61 FTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVLQSLKSNERRNLDSLG---LRKKA 137
Cdd:cd00818 3 FVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGiaeFNAKC 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81576445 138 TDYAKIQINNQLEGFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGLKPVHW 198
Cdd:cd00818 83 REFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
36-828 |
2.97e-65 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 237.53 E-value: 2.97e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 36 EPEIHEFWSRN---KIDLELGstnsGKNFTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPI 112
Cdd:PLN02943 66 EERIYNWWESQgyfKPNFDRG----GDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIAT 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 113 ELKVLQSLKSN--ERRNLDSLGLRKKATDYAKI---QINNQLegfKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNG 187
Cdd:PLN02943 142 QLVVEKMLASEgiKRTDLGRDEFTKRVWEWKEKyggTITNQI---KRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 188 YIYRGLKPVHWSPSSRTALAEAELEYPEEHfSKSIYVSLNITKLSDAvllkleekdlrnkllsslnklFIAIWTTTPWTI 267
Cdd:PLN02943 219 LIYQGSYMVNWSPNLQTAVSDLEVEYSEEP-GTLYYIKYRVAGGSED---------------------FLTIATTRPETL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 268 PGNEAVAINPRinyvfasDQNGNIYLFARDLISEICeklDREFNVLLDvkgsllegleykhptknkfcniviggDYITTE 347
Cdd:PLN02943 277 FGDVAIAVNPE-------DDRYSKYIGKMAIVPMTY---GRHVPIIAD--------------------------RYVDKD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 348 SGTGIVHTAPGHGMDDFNVGQKYQLPITCIVDEKGNLNKHAEKFcglnvLKDANDLIIEDLEKNNLLLLKENYKHRYPYD 427
Cdd:PLN02943 321 FGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAGLY-----WFEAREKLWSDLEETGLAVKKEPHTLRVPRS 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 428 WRTKKPTIFRATEQWFASVEGFRSSALKAIEDVEW--MPKTGKKrIYSMVVGR-GDWCISRQRSWGVPIPVFY----EKE 500
Cdd:PLN02943 396 QRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELtiIPERFEK-IYNHWLSNiKDWCISRQLWWGHRIPVWYivgkDCE 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 501 GKGVLINTETiNHIKSLFEEYGADVwwewdekkllpEKYRNEsdrwekglDTMDVWFDSGS------SWAAVCEQREELQ 574
Cdd:PLN02943 475 EDYIVARSAE-EALEKAREKYGKDV-----------EIYQDP--------DVLDTWFSSALwpfstlGWPDVSAEDFKKF 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 575 YPADLYLEGSDQHRGWFQSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIINggpnqkiqpAYGADV 654
Cdd:PLN02943 535 YPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIK---------EFGTDA 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 655 LRLWVSSVDYSVDVPIGSNILKQLSDVYRKVRNTARYLLGNI--------------HDYDpalEEIDIDQLPLLDQWMLN 720
Cdd:PLN02943 606 LRFTLALGTAGQDLNLSTERLTSNKAFTNKLWNAGKFVLQNLpsqsdtsawehilaCKFD---KEESLLSLPLPECWVVS 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 721 RLVEVSDEVTIAYENYEFSKFFQILQSFCVVDLSNFYLDIAKDRLYVSAKTQFRRRScQFVMSRIVENLAVIISPVLCHM 800
Cdd:PLN02943 683 KLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKTRLYHSGDNSALSRA-QAVLLYVFENILKLLHPFMPFV 761
|
810 820 830
....*....|....*....|....*....|.
gi 81576445 801 AEDIWQNIPY---STIEKSVFERRWPKFPES 828
Cdd:PLN02943 762 TEELWQALPYrkeALIVSPWPQTSLPKDLKS 792
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
437-670 |
4.01e-46 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 167.98 E-value: 4.01e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 437 RATEQWFASVEGFRSSALKAIEDVEWMPKTGKKRIYSMVVGRGDWCISRQRSWGVPIPVfyekegkgvlintetinhiks 516
Cdd:cd00668 137 RITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLPE--------------------- 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 517 lfeeygadvwwewdekkllpekyrnesdrwekglDTMDVWFDSGSSWAAVCEQREE-----LQYPADLYLEGSDQHRGWF 591
Cdd:cd00668 196 ----------------------------------DVFDVWFDSGIGPLGSLGYPEEkewfkDSYPADWHLIGKDILRGWA 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 592 QSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIINggpnqkiqpAYGADVLRLWV-SSVDYSVDVPI 670
Cdd:cd00668 242 NFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVE---------KYGADALRYYLtSLAPYGDDIRL 312
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
428-661 |
3.19e-44 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 164.73 E-value: 3.19e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 428 WRTKKPTIFRATEQWFASVEGFRSSALKAIE--DVEWMPKTGKKRIYSMVVGRGDWCISRQRSWGVPIPVFYEKEGKGVL 505
Cdd:cd00817 157 SRSGDVIEPLLKPQWFVKVKDLAKKALEAVKegDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWV 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 506 INTETinhikslfeeygadvwWEWDEKKLLPEKYRNESDRWEKGLDTMDVWFDSgSSWAAVC----EQREELQ--YPADL 579
Cdd:cd00817 237 VAREE----------------DEAIDKAAPEACVPCGGEELKQDEDVLDTWFSS-SLWPFSTlgwpEETKDLKkfYPTSL 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 580 YLEGSDQHRGWFQSSLLTSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIINGgpnqkiqpaYGADVLRLWV 659
Cdd:cd00817 300 LVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDG---------YGADALRFTL 370
|
..
gi 81576445 660 SS 661
Cdd:cd00817 371 AS 372
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
67-848 |
3.39e-44 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 173.93 E-value: 3.39e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 67 PPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVLQSLKSNERRNLDSLGLRKKATDYAKIQ-- 144
Cdd:PLN02381 136 PPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKde 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 145 ----INNQLegfKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGLKPVHWSPSSRTALAEAELEYPEEHFSK 220
Cdd:PLN02381 216 yggtILNQL---RRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKERT 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 221 SIYVSLNITKLSDAVLLKLE---EKDLRNkllsslnklfIAIWTTTPWTIPGNEAVAINPRinyvfasdqngniylfard 297
Cdd:PLN02381 293 LLKVPGYDKPVEFGVLTSFAyplEGGLGE----------IVVATTRIETMLGDTAIAIHPD------------------- 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 298 liseicekldrefnvllDVKGSLLEGLEYKHPTKNKFCNIVIGGDYITTESGTGIVHTAPGHGMDDFNVGQKYQLPITCI 377
Cdd:PLN02381 344 -----------------DERYKHLHGKFAVHPFNGRKLPIICDAILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINI 406
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 378 VDEKGNLNKHA-EKFCGLNVLKdANDLIIEDLEKNNLLLLKENYKHRYPYDWRTK---KPTIfraTEQWFASVEGFRSSA 453
Cdd:PLN02381 407 FTDDGKINSNGgSEFAGMPRFA-AREAVIEALQKKGLYRGAKNNEMRLGLCSRTNdvvEPMI---KPQWFVNCSSMAKQA 482
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 454 LKAIED-----VEWMPKTGKKRIYSMVVGRGDWCISRQRSWGVPIPVFYekegkgvlINTEtinhiKSLFEEYGA--DVW 526
Cdd:PLN02381 483 LDAAIDgenkkLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWY--------VTLE-----DDQLKELGSynDHW 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 527 W-EWDEKKLLPE---KYRNESDRWEKGLDTMDVWFDSG------SSWAAVCEQREELqYPADLYLEGSDQHRGWFQSSLL 596
Cdd:PLN02381 550 VvARNESDALLEasqKFPGKKFELSQDPDVLDTWFSSGlfplsvLGWPDDTDDLKAF-YPTSVLETGHDILFFWVARMVM 628
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 597 TSVAVNNKPPYKTVLTHGFALDENGRKMSKSLGNVVDPNIIING---------------GPNQKIQ-------------P 648
Cdd:PLN02381 629 MGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGisleglhkrleegnlDPKELVVakegqkkdfpngiA 708
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 649 AYGADVLRLWVSSVDYSVDvPIGSNILKQLSdvYR----KVRNTARYLLGNI-HDYDPALeEIDIDQLPLLDQWMLNRLV 723
Cdd:PLN02381 709 ECGTDALRFALVSYTAQSD-KINLDILRVVG--YRqwcnKLWNAVRFAMSKLgDDYTPPA-TLSVETMPFSCKWILSVLN 784
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 724 EVSDEVTIAYENYEFSKFFQILQSFCVVDLSNFYLDIAKDRLYVSAKT-QFRRRSCQFVMSRIVENLAVIISPVLCHMAE 802
Cdd:PLN02381 785 KAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNPEfASERAAAQDTLWICLDTGLRLLHPFMPFVTE 864
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 81576445 803 DIWQNIPY---STIEKSVFERRWPKFPESWLNPELNEH-------ISNLRTLRVEI 848
Cdd:PLN02381 865 ELWQRLPQpkdHTRKDSIMISEYPSAVEAWTNEKVEYEmdlvlstVKCLRSLRAEV 920
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
36-828 |
9.67e-41 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 162.23 E-value: 9.67e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 36 EPEIHEFWSRNKIDLELGSTNSGKNFTLhDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKV-HFIpGWDCHGLPIEL 114
Cdd:TIGR00396 7 EEKWQQKWDENKTFKVTDDSSKPKYYIL-SMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVlHPI-GWDAFGLPAEN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 115 KVLQSlksnerrnldslglRKKATDYAKIQINNQLEGFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGLK 194
Cdd:TIGR00396 85 AAIKR--------------GIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 195 PVHWSPSSRTALAEAEL---------EYPEEHFSKSIYVsLNITKLSDAVLLKLEEKDL---------RN---------- 246
Cdd:TIGR00396 151 DVNWCPNDGTVLANEQVdsdgrswrgDTPVEKKELKQWF-LKITAYAEELLNDLEELDHwpesvkemqRNwigksegvei 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 247 --KLLSSLNKlfIAIWTTTPWTIPGNEAVAINPRINYV-FASDQNGNIYLFardlISEICEKLDREFNVLLDVKGSLLEG 323
Cdd:TIGR00396 230 tfKIADHDEK--ITVFTTRPDTIFGVTYLALAPEHPLVeKAAENNPKVAAF----IKKILNKTVAERTKATKEKKGVDTG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 324 LEYKHPTKNKFCNIVIgGDYITTESGTGIVHTAPGHGMDDFNVGQKYQLPITCIVDEKGNLNKHAEKFCGLNVLKDANDL 403
Cdd:TIGR00396 304 IKAIHPLTGEKIPIWV-ANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLSLTAAYTEDGVLVNSGEF 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 404 iiedleknnllllkenykhrypydwrtkkptifrateqwfasvEGFRSS-ALKAIEDveWMPKTGKKRiySMVVGR-GDW 481
Cdd:TIGR00396 383 -------------------------------------------NGLNSSeARNAIID--MLEKEGKGK--RKVNYRlRDW 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 482 CISRQRSWGVPIPVFYEKEGKGVLINTETINHIKSLFEEY---GADVWWEWDEKKLLPEKYRNESDRWEKglDTMDVWfd 558
Cdd:TIGR00396 416 GFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYdgdGGSPLSRIPEWVNVTCPSCGKPALRET--DTMDTF-- 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 559 SGSSW---AAVCEQ-------REELQY--PADLYLEGSDQ---H----RGWFQssLLTSV-AVNNKPPYKTVLTHG---- 614
Cdd:TIGR00396 492 AGSSWyylRYLDPKntdgpfdKEKAEYwlPVDLYIGGIEHailHllyaRFFHK--FLRDIgYVNTKEPFKKLINQGmvlg 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 615 FALDENGR---------------------------KMSKSLGNVVDPNIIINggpnqkiqpAYGADVLRLWV-------S 660
Cdd:TIGR00396 570 FYYPPNGKvpadvlterdekgkdkaggelvyvgyeKMSKSKGNGIDPQEIVE---------SYGADALRLFImfmgpiaA 640
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 661 SVDYSVDVPIGSNilKQLSDVYRKVRNtaryllgniHDYDPALEEIDIDQLPLLDQWMLNRLVEVSDEVTiayENYEFSK 740
Cdd:TIGR00396 641 SLEWNESGLEGAR--RFLDRVWNLVYE---------ITGELDAASLTVTALEEAQKELRRDVHKFLKKVT---EDLEKRE 706
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 741 FFQILQSFCVVdLSNFYLDIAKDRLYVSAktqfrrrscqfvmsriVENLAVIISPVLCHMAEDIWQNIPYStiEKSVFER 820
Cdd:TIGR00396 707 SFNTAISAMME-LLNKLYKAKKEALMLEY----------------LKGFVTVLSPFAPHLAEELWEKLGSE--PFIIDNA 767
|
....*...
gi 81576445 821 RWPKFPES 828
Cdd:TIGR00396 768 KWPVVDET 775
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
61-201 |
2.30e-40 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 151.42 E-value: 2.30e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 61 FTLHDGPPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVlQSLKSNERRNLDSLGLRKKATDY 140
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKA-ERKGGRKKKTIWIEEFREDPKEF 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81576445 141 AKIQINNQLEGFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGLKPVHWSPS 201
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPVRITEQ 141
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
67-210 |
6.27e-32 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 128.90 E-value: 6.27e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 67 PPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVLQSLKSNE--RRNLDSLGLRKKATDYAKIQ 144
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGktRHDLGREEFLEKCWEWKEES 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81576445 145 INNQLEGFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGLKPVHWSPSSRTALAEAE 210
Cdd:cd00817 89 GGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIE 154
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
36-854 |
3.34e-31 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 132.25 E-value: 3.34e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 36 EPEIHEFWSRNKI--DLELGSTNSGKNFTLhDGPPYANGS-LHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPI 112
Cdd:PLN02563 86 EPKWQRYWEENRTfrTPDDVDTSKPKFYVL-DMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPA 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 113 ELKVLQSlksnerrnldslGLRKKATdyAKIQINNQLEGFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRG 192
Cdd:PLN02563 165 EQYAIET------------GTHPKIT--TLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQA 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 193 LKPVHWSPSSRTALAEAEL--------EYPEEHFSKSIYVsLNITKLSDAVLLKLEEKD--------------------L 244
Cdd:PLN02563 231 EVPVNWCPALGTVLANEEVvdglsergGHPVIRKPMRQWM-LKITAYADRLLEDLDDLDwpesikemqrnwigrsegaeL 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 245 RNKLLSSLNKLF---IAIWTTTPWTIPGNEAVAINPR---INYVFASDQNGNIYLFaRDLISeicEKLDREFNVLLDVKG 318
Cdd:PLN02563 310 DFSVLDGEGKERdekITVYTTRPDTLFGATYLVVAPEhplLSSLTTAEQKEAVEEY-VDAAS---RKSDLERTELQKEKT 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 319 SLLEGLEYKHPTKNKFCNIVIgGDYITTESGTGIVHTAPGHGMDDFNVGQKYQLPITCIVD-EKGNLNKHAEKFCGLNVL 397
Cdd:PLN02563 386 GVFTGSYAINPATGEAIPIWV-ADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKpADGNEDDAEKAYTGEGVI 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 398 KDANDLIIedleknnllllkenykhrypydwrtkkptifrateqwfaSVEGFRSS-ALKAIedVEWMPKT--GKKRI-YS 473
Cdd:PLN02563 465 VNSSSSGL---------------------------------------DINGLSSKeAAKKV--IEWLEETgnGKKKVnYK 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 474 MvvgrGDWCISRQRSWGVPIPVFY-EKEGKGV-LINTETINHIKSL--FEEYGAdvwwewdekkllPEKYRNESDRWEKG 549
Cdd:PLN02563 504 L----RDWLFARQRYWGEPIPVVFlEDSGEPVpVPESDLPLTLPELddFTPTGT------------GEPPLAKAVSWVNT 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 550 LD------------TMDVWfdSGSSW------------AAVCEQREELQYPADLYLEGSDQ---H----RGWFQsSLLTS 598
Cdd:PLN02563 568 VDpssgkparretnTMPQW--AGSCWyylrfmdpknsnALVDKEKEKYWMPVDLYVGGAEHavlHllyaRFWHK-VLYDI 644
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 599 VAVNNKPPYKTVLTHGFAL---------DENGR---------------------------------------------KM 624
Cdd:PLN02563 645 GVVSTKEPFQCLVNQGMILgeveytafkDSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKM 724
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 625 SKSLGNVVDPNIIINggpnqkiqpAYGADVLRLWVSSVDYSVDVPIGSNilKQLSDVYRKVRNTARYLLG------NIHD 698
Cdd:PLN02563 725 SKSRGNVVNPDDVVS---------EYGADSLRLYEMFMGPLRDSKTWST--SGVEGVHRFLGRTWRLVVGaplpdgSFRD 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 699 YDPAL-EEIDIDQLPLLDQWMlnrlvevsDEVTIAYENYEFSKFFQILQSFcvvdlsnfyldiakdrlyVSAKTQFRRRS 777
Cdd:PLN02563 794 GTVVTdEEPSLEQLRLLHKCI--------AKVTEEIESTRFNTAISAMMEF------------------TNAAYKWDKVP 847
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81576445 778 cqfvmSRIVENLAVIISPVLCHMAEDIWQNIPYSTiekSVFERRWPKFPESWLnpelnehISNLRTLRVEINKAIEG 854
Cdd:PLN02563 848 -----REAIEPFVLLLSPYAPHLAEELWFRLGHSN---SLAYEPWPEANPSYL-------VDDTVVLPVQINGKTRG 909
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
715-869 |
1.57e-30 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 117.50 E-value: 1.57e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 715 DQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFCVVDLSNFYLDIAKDRLYVSAKTQfrrrSCQFVMSRIVENLAVIIS 794
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDS----RAQTTLYEVLETLLRLLA 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81576445 795 PVLCHMAEDIWQNipystieKSVFERRWPKFPESWlNPELNEHISnlrtLRVEINKAIEGCRTQQMIGAALETEV 869
Cdd:pfam08264 77 PFMPFITEELWQK-------ESIHLAPWPEDAELE-EAELEEAFE----LRQEIVQAIRKLRSELKIKKSLPLEV 139
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
74-833 |
1.33e-25 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 114.20 E-value: 1.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 74 LHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIeLKVLQSLKSNERRNLDSLglrkkaTDYAKIqINNQLEGF- 152
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPI-LGIAERIARGDPETIELY------KSLYGI-PEEELEKFk 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 153 -----------------KRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGLKPVHWSPSSRTALAEAELEYPE 215
Cdd:PRK12300 73 dpeyiveyfseeakedmKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 216 EhfsKSIyvslnitklSDAVLLKLEEkdlrnkllssLNKLFIAIWTTTPWTIPGNEAVAINPRINYVFASDQNGNIylfa 295
Cdd:PRK12300 153 E---PEI---------VEYTLIKFEE----------SEDLILPAATLRPETIFGVTNLWVNPDATYVKAEVDGEKW---- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 296 rdLISEIC-EKL---DREFNVLLDVKGSLLEGLEYKHPTKNKFCnIVIGGDYITTESGTGIVHTAPGH------GMDDFN 365
Cdd:PRK12300 207 --IVSKEAaEKLsfqDRDVEIIEEIKGSELIGKKVKNPVTGKEV-PILPADFVDPDNGTGVVMSVPAHapydyvALRDLK 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 366 VGQKYQLPITCI----VDE------------------------------------KGNLNKHAEKFCGLNVlKDANDLII 405
Cdd:PRK12300 284 KNKELLDVIEPIplieVEGygefpakevveklgiksqedpeleeatkevyraefhKGVLKENTGEYAGKPV-REAREKIT 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 406 EDLEKNnllllkenYKHRYPYDWrTKKPTIFRA-TE--------QWFA--SVEGFRSSALKAIEDVEWMPKTGKKRIYSM 474
Cdd:PRK12300 363 KDLIEK--------GIADIMYEF-SNRPVYCRCgTEcvvkvvkdQWFIdySDPEWKELAHKALDNMEIIPEEYRKEFENT 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 475 VVGRGDWCISRQRSWGVPIP-----------------VFYekegkgvlinteTINH-IKslfeeygadvwwewdEKKLLP 536
Cdd:PRK12300 434 IDWLKDRACARRRGLGTRLPwdeewiieslsdstiymAYY------------TIAHkIR---------------EYGIKP 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 537 EKYRNESdrWEKGL----DTMDVWFDSGSSWAAVCEQREELQ--YPADLYLEGSD-----------QHRGWFQSSLLTS- 598
Cdd:PRK12300 487 EQLTPEF--FDYVFlgkgDPEEVSKKTGIPKEILEEMREEFLywYPVDWRHSGKDlipnhltffifNHVAIFPEEKWPRg 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 599 VAVNnkppyktvlthGFALDEnGRKMSKSLGNVVdpniiinggPNQKIQPAYGADVLRLWV-SSVDYSVDVPIGSNILKQ 677
Cdd:PRK12300 565 IVVN-----------GFVLLE-GKKMSKSKGNVI---------PLRKAIEEYGADVVRLYLtSSAELLQDADWREKEVES 623
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 678 LSDVYRKVRNTARYLlgnihdydpaLEEIDIDQLPLLDQWMLNRLVEVSDEVTIAYENYEFSKFFQILqsfcvvdlsnFY 757
Cdd:PRK12300 624 VRRQLERFYELAKEL----------IEIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEA----------FY 683
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81576445 758 LdiakdrLYVSAKTQFRR--RSCQFVMSRIVENLAVIISPVLCHMAEDIWQNIPYSTIeksVFERRWPKFPESWLNPE 833
Cdd:PRK12300 684 E------LLNDLRWYLRRvgEANNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGF---VSLEKWPEPDESKIDEE 752
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
68-830 |
9.18e-25 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 111.30 E-value: 9.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 68 PYANGSLHMGHALNKVLKDIINKYKTLQGFKV-HfiP-GWDCHGLPIElkvlQ-SLKSNE-------------RRNLDSL 131
Cdd:COG0495 42 PYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVlH--PmGWDAFGLPAE----NaAIKNGVhpaewtyenianmRRQLKRL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 132 GL-----RKKAT---DYAKiqinnqlegfkrwgiWGDWdnpyltlkknyesaqigVFGKMFLNGYIYRGLKPVHWSPSSR 203
Cdd:COG0495 116 GLsydwsREIATcdpEYYK---------------WTQW-----------------IFLQLYEKGLAYRKEAPVNWCPVDQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 204 TALAEAELE--------YPEEHfsKSI--YVsLNITKLSDavllkleekdlrnKLLSSLNKL------------------ 255
Cdd:COG0495 164 TVLANEQVIdgrcwrcgAPVEK--KELpqWF-LKITDYAD-------------ELLDDLDKLdgwpekvktmqrnwigrs 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 256 ------F--------IAIWTTTPWTIPGNEAVAI---NPRINYVFASDQNGNIYLFARD--LISEIcEK--LDREfnvll 314
Cdd:COG0495 228 egaevdFpvegsdekITVFTTRPDTLFGATFMVLapeHPLVKELATPEQNAAVAAFIEEakKKSEI-ERtsETKE----- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 315 dvKGSLLEGLEYKHPTKNKFCNIVIGgDYITTESGTGIVHTAPGHGMDDFNVGQKYQLPITCIV----DEKGNLNKHA-- 388
Cdd:COG0495 302 --KTGVFTGLYAINPLTGEKIPIWIA-DYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIapedGDDPDILEEAyt 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 389 --------EKFCGLNVlKDANDLIIEdleknnllllkenykhrypydwrtkkptifrateqWFASvEGFrssalkaiedv 460
Cdd:COG0495 379 gdgvlinsGEFDGLDS-EEAKEAIIE-----------------------------------WLEE-KGL----------- 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 461 ewmpktGKKRI-YSMvvgRgDWCISRQRSWGVPIPVFYEKEGKGVLIntetinhikslfeeygadvwwewDEKKL---LP 536
Cdd:COG0495 411 ------GKRKVnYRL---R-DWLISRQRYWGEPIPIIHCEDCGVVPV-----------------------PEDQLpveLP 457
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 537 E----------------------------KYRNESDrwekgldTMDVWFDSgsSW------------AAVceQREELQY- 575
Cdd:COG0495 458 EdvdfdptggsplarapewvnvtcpkcggPARRETD-------TMDTFVDS--SWyylrytdphndeAPF--DPEAANYw 526
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 576 -PADLYLEGSDqH--------RGWfqssllTSV-----AVNNKPPYKTVLTHG--FALDENGR------KMSKSLGNVVD 633
Cdd:COG0495 527 lPVDQYIGGIE-HailhllyaRFF------TKVlrdlgLVSFDEPFKRLLTQGmvLEVGKDGVviggieKMSKSKGNVVD 599
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 634 PNIIINggpnqkiqpAYGADVLRLWV-------SSVDYSVDVPIGSNilKQLSDVYRKVRNTARYLLGNIHDYDPALEEI 706
Cdd:COG0495 600 PDEIIE---------KYGADTLRLFEmfagppeRDLEWSDSGVEGAY--RFLNRVWRLVVDEAEALKLDVADLSEADKEL 668
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 707 DIdqlplldqwMLNRLVevsDEVTIAYENYEF----SKffqilqsfcVVDLSNFyldiakdrLYvsaKTQFRRRSCQFVM 782
Cdd:COG0495 669 RR---------ALHKTI---KKVTEDIERLRFntaiAA---------LMELVNA--------LY---KAKDSGEADRAVL 716
|
890 900 910 920
....*....|....*....|....*....|....*....|....*...
gi 81576445 783 SRIVENLAVIISPVLCHMAEDIWQNIPYstiEKSVFERRWPKFPESWL 830
Cdd:COG0495 717 REALETLVLLLAPFAPHIAEELWERLGH---EGSVADAPWPEADEAAL 761
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
680-844 |
9.05e-19 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 84.91 E-value: 9.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 680 DVYRKV----RNTARYLLG--NIHDYDPALEEIDIDQLPLLDQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFcVVDL 753
Cdd:cd07961 8 EVVRKVllplWNAYRFFVTyaNLDGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEF-IDEL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 754 SNFYLDIAKDRLYVSAKTQFRRRSCQfVMSRIVENLAVIISPVLCHMAEDIWQNI--PYSTIEKSVFERRWPKFPESWLN 831
Cdd:cd07961 87 TNWYIRRNRKRFWGEEGDDDKLAAYA-TLYEVLLTLSRLMAPFTPFITEEIYQNLrrELGDAPESVHLLDWPEVDESLID 165
|
170
....*....|...
gi 81576445 832 PELNEHISNLRTL 844
Cdd:cd07961 166 EELEEAMELVREI 178
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
684-808 |
3.84e-18 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 81.83 E-value: 3.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 684 KVRNTARYLLGNIHDYDPAleEIDIDQLPLLDQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFCVVDLSNFYLDIAKD 763
Cdd:cd07962 15 KLWNAARFVLMNLEDDDEP--EEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYLELVKP 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 81576445 764 RLYvsAKTQFRRRSCQFVMSRIVENLAVIISPVLCHMAEDIWQNI 808
Cdd:cd07962 93 RLY--GEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
68-198 |
1.04e-16 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 82.30 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 68 PYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIElkvlqslKSNERRNLDslglRKKATDYAKIQINN 147
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAE-------NAAIKIGRD----PEDWTEYNIKKMKE 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 81576445 148 QlegFKRWGIWGDWDNPYLTLKKNYESAQIGVFGKMFLNGYIYRGLKPVHW 198
Cdd:cd00812 78 Q---LKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
425-806 |
6.97e-16 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 81.70 E-value: 6.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 425 PYDWRTKKPTIFRATEQWFasvegFRSSA-----LKAIEDV-EWMPKTgKKRIYSMV-VGRGDWCISRQRSWGVPIP--- 494
Cdd:COG0143 169 PRSAISGAPPELREEEHYF-----FRLSKyqdrlLEWIEENpDIQPEV-RNEVLSWLkEGLQDLSISRDFDWGIPVPgdp 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 495 --VFYekegkgvlintetinhikslfeeygadVW-----------WEWDEKKLLPEKYrnesDRWEKGLDTMDV------ 555
Cdd:COG0143 243 gkVFY---------------------------VWfdaligyisatKGYADDRGLPEDF----EKYWPAPDTELVhfigkd 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 556 --------WfdsgsswaavceqreelqyPAdlYLEGSdqhrGWfqsslltsvavnnkPPYKTVLTHGFaLDENGRKMSKS 627
Cdd:COG0143 292 iirfhaiiW-------------------PA--MLMAA----GL--------------PLPKKVFAHGF-LTVEGEKMSKS 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 628 LGNVVDPNIIINggpnqkiqpAYGADVLRLWvssvdYSVDVPIGSNI---LKQL-----SD--------VYRKVRNTARY 691
Cdd:COG0143 332 RGNVIDPDDLLD---------RYGPDALRYY-----LLREVPFGQDGdfsWEDFvarvnSDlandlgnlASRTLSMIHKY 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 692 LLGNIhdydPALEEIDidqlpLLDQWMLNRLVEVSDEVTIAYENYEFSK-FFQILQsfcVVDLSNFYLDIAKDrlYVSAK 770
Cdd:COG0143 398 FDGKV----PEPGELT-----EADEELLAEAEAALEEVAEAMEAFEFRKaLEEIMA---LARAANKYIDETAP--WKLAK 463
|
410 420 430
....*....|....*....|....*....|....*....
gi 81576445 771 TQFRRRsCQFVMS---RIVENLAVIISPVLCHMAEDIWQ 806
Cdd:COG0143 464 DEDPER-LATVLYtllEALRILAILLKPFLPETAEKILE 501
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
68-806 |
8.63e-16 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 81.66 E-value: 8.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 68 PYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVLQslksnerRNLDSLGLRKKA-----TDYAK 142
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQ-------EGLTPKELVDKYheefkDDWKW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 143 IQINNqlEGFKRwgiwgdwdnpyLTLKKNYESAQiGVFGKMFLNGYIYRGLKPVHWSPSSRTALAEAELEypeehfsksi 222
Cdd:TIGR00398 81 LNISF--DRFIR-----------TTDEEHKEIVQ-KIFQKLKENGYIYEKEIKQLYCPECEMFLPDRYVE---------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 223 yvslnitklsdavllkleekdlrnkllsslnklfiaiwtttpwtipgneavAINPRINYvfasdqngniylfaRDLISEI 302
Cdd:TIGR00398 137 ---------------------------------------------------GTCPKCGS--------------EDARGDH 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 303 CEKLdrefnvlldvkGSLLEGLEYKHPtKNKFCniviggdyittesGTGIVHTAPGHGMDDFNVGQKYQLPITCIVDEKG 382
Cdd:TIGR00398 152 CEVC-----------GRHLEPTELINP-RCKIC-------------GAKPELRDSEHYFFRLSAFEKELEEWIRKNPESG 206
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 383 NLNKHAEKFcglnvlkdandliiedleknnllllkenykhrypydwrtkkptifraTEQWFASvegfrssalkaiedvew 462
Cdd:TIGR00398 207 SPASNVKNK-----------------------------------------------AQNWLKG----------------- 222
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 463 mpktgkkriysmvvGRGDWCISRQRS-WGVPIPvfyEKEGKGVLINTE-TINHIKSLFEEYGADVWWewdekkllpEKYR 540
Cdd:TIGR00398 223 --------------GLKDLAITRDLVyWGIPVP---NDPNKVVYVWFDaLIGYISSLGILSGDTEDW---------KKWW 276
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 541 NESDRWEK----GLDTmdVWFDSgsswaavceqreeLQYPAdlYLEGSdqhrGWfqsslltsvavnNKPpyKTVLTHGFA 616
Cdd:TIGR00398 277 NNDEDAELihfiGKDI--VRFHT-------------IYWPA--MLMGL----GL------------PLP--TQVFSHGYL 321
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 617 LDEnGRKMSKSLGNVVDPNIIINGgpnqkiqpaYGADVLRLWVSSV-------DYSVDV---PIGSNILKQLSD-VYRKV 685
Cdd:TIGR00398 322 TVE-GGKMSKSLGNVVDPSDLLAR---------FGADILRYYLLKErplgkdgDFSWEDfveRVNADLANKLGNlLNRTL 391
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 686 RNTARYLLGNIHDYDPALEEIDidqlPLLDQwmLNRLVEVSDEvtiAYENYEFSKFFQILqsFCVVDLSNFYLDIAKDrl 765
Cdd:TIGR00398 392 GFIKKYFNGVLPSEDITDEEDK----KLLKL--INEALEQIDE---AIESFEFRKALREI--MKLADRGNKYIDENKP-- 458
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 81576445 766 YVSAKTQFRRRSCQFVMSRIVENLAVIISPVLCHMAEDIWQ 806
Cdd:TIGR00398 459 WELFKQSPRLKELLAVCSMLIRVLSILLYPIMPKLSEKILK 499
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
480-806 |
7.37e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 72.22 E-value: 7.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 480 DWCISRQR-SWGVPIPvfyekegkgvlintetinhikslfeeygadvwweWDEKKllpekyrnesdrwekgldTMDVWFD 558
Cdd:PRK11893 200 DLSISRTNfDWGIPVP----------------------------------GDPKH------------------VIYVWFD 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 559 SGSSW--AAVCEQREELQ-------YPADLYLEGSDQHR----GWfqSSLLTSvavNNKPPYKTVLTHGFALDEnGRKMS 625
Cdd:PRK11893 228 ALTNYltALGYPDDEELLaelfnkyWPADVHLIGKDILRfhavYW--PAFLMA---AGLPLPKRVFAHGFLTLD-GEKMS 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 626 KSLGNVVDPNIIINggpnqkiqpAYGADVLRLWVSSvdysvDVPIGsnilkQLSDvYRKVRNTARY------LLGN---- 695
Cdd:PRK11893 302 KSLGNVIDPFDLVD---------EYGVDAVRYFLLR-----EIPFG-----QDGD-FSREAFINRInadlanDLGNlaqr 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 696 ----IHDY-DPALEEIDIdqLPLLDQWMLNRLVEVSDEVTIAYENYEFSKFFQILqsFCVVDLSNFYLDIAKdrLYVSAK 770
Cdd:PRK11893 362 tlsmIAKNfDGKVPEPGA--LTEADEALLEAAAALLERVRAAMDNLAFDKALEAI--LALVRAANKYIDEQA--PWSLAK 435
|
330 340 350
....*....|....*....|....*....|....*....
gi 81576445 771 TQFRRRSCqfVMSRIVENL---AVIISPVLCHMAEDIWQ 806
Cdd:PRK11893 436 TDPERLAT--VLYTLLEVLrgiAVLLQPVMPELAAKILD 472
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
68-212 |
7.70e-13 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 71.17 E-value: 7.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 68 PYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVlqslksnERRNLDSLGLrkkATDYAKIQINN 147
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKA-------EKEGITPEEL---VDRYHEIHRED 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81576445 148 qlegFKRWGIwgDWDNPYLTL-KKNYESAQiGVFGKMFLNGYIYRGLKPVHWSPSSRTALAEAELE 212
Cdd:pfam09334 78 ----FKKFNI--SFDDYGRTTsERHHELVQ-EFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE 136
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
68-192 |
1.04e-12 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 70.25 E-value: 1.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 68 PYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVLQslksnerrnldsLGLRKKatDYAKIQINN 147
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEE------------EGVTPQ--ELCDKYHEI 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 81576445 148 QLEGFKRWGIwgDWDNpYL--TLKKNYESAQiGVFGKMFLNGYIYRG 192
Cdd:cd00814 75 FKDLFKWLNI--SFDY-FIrtTSPRHKEIVQ-EFFKKLYENGYIYEG 117
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
420-661 |
2.62e-11 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 65.73 E-value: 2.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 420 YKHRYPYDWRtkkptifRATEQWFA--SVEGFRSSALKAIEDVEWMPkTGKKRIYSMVVGrgdwcISRQRSWGVPIPvfy 497
Cdd:cd00812 117 YKKEAPVNWC-------KLLDQWFLkySETEWKEKLLKDLEKLDGWP-EEVRAMQENWIG-----CSRQRYWGTPIP--- 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 498 ekegkgvlintetinhikslfeeygadvwWEWdekkllpekyrnesdrwekgldTMDVWFDSgsSW-------------- 563
Cdd:cd00812 181 -----------------------------WTD----------------------TMESLSDS--TWyyarytdahnleqp 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 564 --AAVCEQREELQY--PADLYLEGSDQ-----------HRGWFQSSLLTSvavnnKPPyKTVLTHGFALdENGRKMSKSL 628
Cdd:cd00812 208 yeGDLEFDREEFEYwyPVDIYIGGKEHapnhllysrfnHKALFDEGLVTD-----EPP-KGLIVQGMVL-LEGEKMSKSK 280
|
250 260 270
....*....|....*....|....*....|...
gi 81576445 629 GNVVDPNIIINGgpnqkiqpaYGADVLRLWVSS 661
Cdd:cd00812 281 GNVVTPDEAIKK---------YGADAARLYILF 304
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
434-656 |
1.53e-10 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 63.70 E-value: 1.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 434 TIFRATEQWFASVEGFRSSALKAIE---DVEWmPKTGKKRIYSMVV-GRGDWCISRQRS-WGVPIPVFyekEGKGV---- 504
Cdd:cd00814 132 PEWREEEHYFFRLSKFQDRLLEWLEknpDFIW-PENARNEVLSWLKeGLKDLSITRDLFdWGIPVPLD---PGKVIyvwf 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 505 --LINTETInhIKSLFEEYGADVWWEWDEkkllpekyrnesdrwekgldtmdvwfdsgsswaavceqreelqyPADLYLE 582
Cdd:cd00814 208 daLIGYISA--TGYYNEEWGNSWWWKDGW--------------------------------------------PELVHFI 241
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81576445 583 GSDQ---HRGWFQSSLLTSvavnNKPPYKTVLTHGFALDEnGRKMSKSLGNVVDPNIIINggpnqkiqpAYGADVLR 656
Cdd:cd00814 242 GKDIirfHAIYWPAMLLGA----GLPLPTRIVAHGYLTVE-GKKMSKSRGNVVDPDDLLE---------RYGADALR 304
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
605-806 |
6.14e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 62.90 E-value: 6.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 605 PPYKTVLTHGFALdENGRKMSKSLGNVVDPNIIINggpnqkiqpAYGADVLRlwvssvdYSV--DVPIGS---------- 672
Cdd:PRK12267 282 PLPKKVFAHGWWL-MKDGKMSKSKGNVVDPEELVD---------RYGLDALR-------YYLlrEVPFGSdgdfspealv 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 673 --------NILKQLsdVYRKVRNTARYLLGNIhdydPALEEIDidqlpLLDQWMLNRLVEVSDEVTIAYENYEFSKFFQI 744
Cdd:PRK12267 345 erinsdlaNDLGNL--LNRTVAMINKYFDGEI----PAPGNVT-----EFDEELIALAEETLKNYEELMEELQFSRALEE 413
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81576445 745 LQSFcvVDLSNFYLD------IAKDRlyvSAKTQFRRrscqfVMSRIVENL---AVIISPVLCHMAEDIWQ 806
Cdd:PRK12267 414 VWKL--ISRANKYIDetapwvLAKDE---GKKERLAT-----VMYHLAESLrkvAVLLSPFMPETSKKIFE 474
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
673-776 |
1.34e-09 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 56.75 E-value: 1.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 673 NILKQLSDVYRKVRNTARYLLGNIHDYDPaleEIDIDQLPLLDQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFCVVD 752
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRKALGGTQP---KWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL 78
|
90 100
....*....|....*....|....
gi 81576445 753 lsNFYLDIAKDRLYVSAKTQFRRR 776
Cdd:cd07375 79 --NWYLDELKPALQTEELREAVLA 100
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
68-191 |
2.06e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 58.24 E-value: 2.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 68 PYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVLQslksnerrnldsLGLRKKA--TDYAKIqi 145
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEK------------EGITPEEliARYHAE-- 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 81576445 146 nnQLEGFKRWGIwgDWDNPYLT-LKKNYESAQiGVFGKMFLNGYIYR 191
Cdd:PRK00133 77 --HKRDFAGFGI--SFDNYGSThSEENRELAQ-EIYLKLKENGYIYE 118
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
69-113 |
9.37e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 55.96 E-value: 9.37e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 81576445 69 YANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIE 113
Cdd:PRK12267 14 YPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQ 58
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
67-192 |
1.94e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 54.89 E-value: 1.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 67 PPYANGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGLPIELKVLQSLKSNE---RRNLDSLglrkkATDYAKI 143
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQelaDRNSAAF-----KRLWEAL 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 81576445 144 QINNQLegFKRwgiwgdwdnpylTLKKNYESAQIGVFGKMFLNGYIYRG 192
Cdd:PRK11893 84 NISYDD--FIR------------TTDPRHKEAVQEIFQRLLANGDIYLG 118
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
425-656 |
8.65e-07 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 52.29 E-value: 8.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 425 PYDWRTKKPTIFRATEQWFASVEGFRSSALKAI-EDVEWMPKTGKKRIYSMV-VGRGDWCISRQRSWGVPIP-----VFY 497
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLREWIeENNPEWPENVKNMVLEWLkEGLKDRAISRDLDWGIPVPgaegkVFY 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 498 ekegkgVLINTeTINHIkSLFEEYGADV--WWEWdekkllpekyrnesdrWEKGLDTMDVWFdsgsswaavceqreelqy 575
Cdd:pfam09334 247 ------VWLDA-PIGYI-SATKELSGNEekWKEW----------------WPNDPDTELVHF------------------ 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 576 padlylEGSD--QHRGWFQSSLLtsVAVNNKPPyKTVLTHGFaLDENGRKMSKSLGNVVDPNIIINggpnqkiqpAYGAD 653
Cdd:pfam09334 285 ------IGKDiiYFHTIFWPAML--LGAGYRLP-TTVFAHGY-LTYEGGKMSKSRGNVVWPSEALD---------RFPPD 345
|
...
gi 81576445 654 VLR 656
Cdd:pfam09334 346 ALR 348
|
|
| zf-FPG_IleRS |
pfam06827 |
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of ... |
933-960 |
2.49e-04 |
|
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23.
Pssm-ID: 429140 [Multi-domain] Cd Length: 28 Bit Score: 39.11 E-value: 2.49e-04
10 20
....*....|....*....|....*...
gi 81576445 933 GLKCDRCWHYQNITVKGIENTKLCERCA 960
Cdd:pfam06827 1 GEKCPRCWTYIEKVGVGGRSTYFCPRCQ 28
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
1-192 |
4.27e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 44.32 E-value: 4.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 1 MKSKHNKEKKSGFSYKETLN--LLKTDFSMRANSV---IREPEIHEFWSRNKI-----DLELGSTNSGKNFTLHDGPPYA 70
Cdd:PLN02224 1 MAARINTSLHNALSFLKAFNtpLNTKPFSFCRNCFrfsKKLPYYSQFSSGKRAlyctsSSQESTVDEADTFVLTTPLYYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 71 NGSLHMGHALNKVLKDIINKYKTLQGFKVHFIPGWDCHGlpieLKVLQSLKSNERRNLDSLGLRKKATDyakiqinnqle 150
Cdd:PLN02224 81 NAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHG----EKIATSAAANGRNPPEHCDIISQSYR----------- 145
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 81576445 151 gfkrwGIWGDWDNPY----LTLKKNYESAQIGVFGKMFLNGYIYRG 192
Cdd:PLN02224 146 -----TLWKDLDIAYdkfiRTTDPKHEAIVKEFYARVFANGDIYRA 186
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
598-667 |
1.58e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 42.01 E-value: 1.58e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81576445 598 SVAVNNKPPYKTVLTHGFaLDENGRKMSKSLGNVVDPNIIINggpnqkiqpAYGADVLRLWV------SSVDYSVD 667
Cdd:COG0215 241 SEAATGKPFARYWMHNGF-LTVNGEKMSKSLGNFFTVRDLLK---------KYDPEVLRFFLlsahyrSPLDFSEE 306
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
713-808 |
2.80e-03 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 38.73 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 713 LLDQWMLNRLVEVSDEVTIAYENYEFSKffqILQSFcvvdlsnFYldiakdrLYVSAKTQFRRRS----CQFVMSRIVEN 788
Cdd:cd07959 35 FIDRWLLSRLNRLIKETTEAYENMQFRE---ALKEG-------LY-------ELQNDLDWYRERGgagmNKDLLRRFIEV 97
|
90 100
....*....|....*....|
gi 81576445 789 LAVIISPVLCHMAEDIWQNI 808
Cdd:cd07959 98 WTRLLAPFAPHLAEEIWHEL 117
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
36-112 |
4.60e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 40.82 E-value: 4.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 36 EPEIHEFWSRNKI-DLELGSTNSGK------NFtlhdgP-PYANGSLHMGHA--LNKVlkDIINKYKTLQGFKVHFIPGW 105
Cdd:PLN02959 19 EVAVQKWWEEEKVfEAEAGDEPPKPgekffgNF-----PyPYMNGLLHLGHAfsLSKL--EFAAAYHRLRGANVLLPFAF 91
|
....*..
gi 81576445 106 DCHGLPI 112
Cdd:PLN02959 92 HCTGMPI 98
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
681-806 |
6.82e-03 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 37.85 E-value: 6.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 681 VYRKVRNTARYLLGNIHDYDPALEEididqlpllDQWMLNRLVEVSDEVTIAYENYEFSKFFQILQSFcvVDLSNFYLDI 760
Cdd:cd07957 13 VNRTLNMASKYFGGVVPEFGGLTEE---------DEELLEEAEELLEEVAEAMEELEFRKALEEIMEL--ARAANKYIDE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 81576445 761 AKD-RLyvsAKTQFRRRsCQFVMSRIVE---NLAVIISPVLCHMAEDIWQ 806
Cdd:cd07957 82 TAPwKL---AKEEDPER-LATVLYVLLEllrILAILLSPFMPETAEKILD 127
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
342-406 |
7.16e-03 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 38.68 E-value: 7.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81576445 342 DYITTESGTGIVHTAPGHGMDDFNVGQKYQLPIT-CIVDEKGNLNK--------------HAEKFCGLNvLKDANDLIIE 406
Cdd:pfam13603 104 NFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKpVIQPEDGDLDLdimteayteegilvNSGEFDGLD-SEEAKEAIIK 182
|
|
| |
