|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
3-917 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1541.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 3 YKNTLLMPKTEFPMRGNLPKREPAMQEKWAEMNIYETVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKS 82
Cdd:COG0060 1 YKETLNLPKTDFPMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 83 MTGFCAPYVPGWDTHGLPIEQALTNK-GVKR---KEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPA 158
Cdd:COG0060 81 MRGFDVPYVPGWDCHGLPIELKVEKElGIKKkdiEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 159 YEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIYVAFSVKDGKNVLEGDEKYI-IWTTTPWTL 237
Cdd:COG0060 161 YEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSIYVKFPVKDEKALLLLEDAYLvIWTTTPWTL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 238 PANLGISVHPELEYAIVKV-NDEKYIIASELFETVAKTLEWENAEVVKTVKGSELEYTVAKHPFY-----DRDSLVMLGD 311
Cdd:COG0060 241 PANLAVAVHPDIDYVLVEVtGGERLILAEALVEAVLKELGIEDYEVLATFKGAELEGLRYEHPFYyvvgyDRAHPVILGD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 312 HVTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHS 391
Cdd:COG0060 321 YVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 392 YPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAEN-GD 470
Cdd:COG0060 401 YPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDcGE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 471 PIITDETINHVADLFREHGSNVWFEREAKD-LLPEGFTHPGSpNGEFRKETDIMDVWFDSGSSHQAVLEERDDLQRPADL 549
Cdd:COG0060 481 LHRTEEVIGSVAELLEEEGADAWFELDLHRpFLDETLKCPKC-GGTMRRVPDVLDVWFDSGSMHFAVLENREELHFPADF 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 550 YLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDV 629
Cdd:COG0060 560 YLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASSDYWGDL 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 630 RISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENTVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNF 709
Cdd:COG0060 640 RFSDEILKEVRDVYRRLRNTYRFLLANLDDFDPAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNF 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 710 CTIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVTEESVQLTDMPEAVQLD 789
Cdd:COG0060 720 CVEDLSNWYLDISKDRLYTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAEESVHLADWPEVDEEL 799
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 790 DAEALKTKWDAFMTLRDDVLKALEVARNEKVIGKSLNASITLYPTAEMKAMLESINEDLKQLFIVSEYKLGGMMEEAPAD 869
Cdd:COG0060 800 IDEELEAKWDLVREVRSAVLKALEAARKEKLIRQPLEAAVVLYADEELAAALESLGDLLAEELNVSEVELVDDAEDLGKD 879
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 81583658 870 A-----PKYEHTAVVVAQATGETCERCWVVseTIGKDAEHETLCERCATVVKE 917
Cdd:COG0060 880 AlkaldVEGISVTVEVEKADGEKCERCWHY--EVGWTPEHEGLCRRCVRRVQG 930
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
13-833 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 1141.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 13 EFPMRGNLPKREPAMQEKWAEMNIYETVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVP 92
Cdd:TIGR00392 1 KFPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 93 GWDTHGLPIEQALTNK-GV-KRKEMTVAE---FRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVF 167
Cdd:TIGR00392 81 GWDTHGLPIEHKVEKKlGIsGKKEISSLEieeFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 168 GDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQ----DKKSASIYVAFSVKDGKNVLEGDEKY--IIWTTTPWTLPANL 241
Cdd:TIGR00392 161 KEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKenykDVKDPSIYVKFPVKKDKKTYLKVKLSslLIWTTTPWTLPSNL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 242 GISVHPELEYAIVKVN--DEKYIIASELFETVAKTLEWeNAEVVKTVKGSELEYTVAKHPFYDRDSL-------VMLGDH 312
Cdd:TIGR00392 241 AIAVHPDFEYALVQDNtkVEYFILAKKLVEKLYNKAGS-DYEIIKTFKGSDLEGLEYEHPLYDFVSQlkegapvVIGGDH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 313 VTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEAPGFEGLF-------YDKANKPITEKLEEVGALLKL 385
Cdd:TIGR00392 320 VTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGRFvkdadkdIIKANKIIIEQLKDKGLLLKA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 386 TFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFY 465
Cdd:TIGR00392 400 EKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGEGRFGNWLENRPDWCISRQRYWGIPIPIWY 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 466 AENGDPIITDETINHVADLFREHGSNVWFEREAKDLLPEGFTHPGSPnGEFRKETDIMDVWFDSGSSHQAVLE-----ER 540
Cdd:TIGR00392 480 CEDTGEPIVVGSIEELIELIELKGIDAWFEDLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMPYASIHypfenEK 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 541 DDLQRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWV 620
Cdd:TIGR00392 559 FKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRLYV 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 621 SSVDYQSDVRISDDILKQVAEVYRKIR-NTFRFLL--GNLDDFKPSENTVAVAELREVDRYMLVKLNDLITKVKEAYETY 697
Cdd:TIGR00392 639 ASSDPWEDLRFSDEILKQVVEKYRKIRwNTYRFLLtyANLDKFDPLFNSVAVEKFPEEDRWILSRLNSLVEEVNEALEKY 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 698 DFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHeDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVT-EES 776
Cdd:TIGR00392 719 NFHKVLRALQDFIVEELSNWYIRIIRDRLYCEAKDN-DKRAAQTTLYYALLTLVRLLAPFLPHTAEEIYQNLPGGEeEES 797
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81583658 777 VQLTDMPEA------VQLDDAEALKTK-WDAFMTLRDDVLKALEVARNEKVIGKSLNASITLYP 833
Cdd:TIGR00392 798 VHLNLWPEVdeefidEALEANMAIVREiVEAFLALRDAANKKLRQPLKELVIGKSLEAVLKAVE 861
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
16-921 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 1100.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 16 MRGNLPKREPAMQEKWAEMNIYETVQEHTKGRPlFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWD 95
Cdd:PLN02843 1 MRANSVTREPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 96 THGLPIE----QALTNKgvKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMA 171
Cdd:PLN02843 80 CHGLPIElkvlQSLDQE--ARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 172 KKGYIYKGQKPVYWSPTSESALAEAEIEY-QDKKSASIYVAFSVKDGKNVLEGDEKYI-------IWTTTPWTLPANLGI 243
Cdd:PLN02843 158 LNGYIYRGRKPVHWSPSSRTALAEAELEYpEGHVSKSIYVAFPVVSPSETSPEELEEFlpglslaIWTTTPWTMPANAAV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 244 SVHPELEYAIVKV----NDE---------------------KYIIASELFETVAKTLEWEnAEVVKTVKGSELEYTVAKH 298
Cdd:PLN02843 238 AVNDKLQYSVVEVqsfsEDEstsggnkkkrpgnvlkeqqklFLIVATDLVPALEAKWGVK-LVVLKTFPGSDLEGCRYIH 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 299 PFYDRDSLVML-GDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEAPGFEGL-FYDKANKPITEKL 376
Cdd:PLN02843 317 PLYNRESPVVIgGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLsVLGEGNAAVVEAL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 377 EEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRA 456
Cdd:PLN02843 397 DEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQGENRIRAMVSGRSDWCISRQRT 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 457 WGVPIPVFY-AENGDPIITDETINHVADLFREHGSNVWFEREAKDLLPEGFTHPGSpngEFRKETDIMDVWFDSGSSHQA 535
Cdd:PLN02843 477 WGVPIPVFYhVETKEPLMNEETIAHVKSIVAQKGSDAWWYMDVEDLLPEKYRDKAS---DYEKGTDTMDVWFDSGSSWAG 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 536 VLEERDDLQRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMD------ 609
Cdd:PLN02843 554 VLGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEggknqk 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 610 ---QLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPsENTVAVAELREVDRYMLVKLNDL 686
Cdd:PLN02843 634 qepAYGADVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKP-DNAVPYEDLPSIDKYALFQLENV 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 687 ITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVW 766
Cdd:PLN02843 713 VNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAW 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 767 PYIP----GVTEESVQLTDMPEA----VQLDDAEALktKWDAFMTLRDDVLKALEVARNEKVIGKSLNASITLY-PTAEM 837
Cdd:PLN02843 793 QNLPfqedGSAAESVFEAGWPTPneewLSFPAEDVD--FWSLLLEVRDEVNKVLESARNGKLIGASLEAKVYLHaSDASL 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 838 KAMLESIN------EDLKQLFIVSEYKLGGMMEEAPADAPKYEHTA--------VVVAQATGETCERCWVVSETIGKDAE 903
Cdd:PLN02843 871 AARLAELCgasngaDELRRIFITSQVEVVSSEDDETAACGSYTGEYvegagrvwVGVSRADGSKCERCWNYSPAVGSFSD 950
|
970
....*....|....*...
gi 81583658 904 HETLCERCATVVKENYVK 921
Cdd:PLN02843 951 HPTLCERCYPVVIAQPPP 968
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
26-632 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 778.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 26 AMQEKWAEMNIYETVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQAL 105
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 106 TNK-----GVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQ 180
Cdd:pfam00133 81 EKKlgikeKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 181 KPVYWSPTSESALAEAEIEYQDKKSASIYVAFSVKDGKnvlegDEKYIIWTTTPWTLPANLGISVHPELEYAIvkvNDEK 260
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDE-----GASLVIWTTTPWTLPGNTAVAVNPEFDYVI---TGEG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 261 YIIASELFETVAKTLEweNAEVVKTVKGSELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYG 340
Cdd:pfam00133 233 YILAEALLKSLYKKGT--DKKILEDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 341 LEVLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKE 420
Cdd:pfam00133 311 LEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQ 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 421 LLEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDPII-TDETINHVADLFREHGSNVWFEREAK 499
Cdd:pfam00133 391 ALEAVEKVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVcRGELFELVAGRFEEEGSIKWLHREAK 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 500 DLLpegfthpGSPNGEFRKETDIMDVWFDSGSSHQAVL----EERDDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTG 573
Cdd:pfam00133 471 DKL-------GYGKGTLEQDEDVLDTWFSSGSWPFSTLgwpfVNTEEFKKffPADMLLEGSDQTRGWFYRMIMLSTALTG 543
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 81583658 574 KAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRIS 632
Cdd:pfam00133 544 SVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
9-849 |
1.19e-152 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 469.67 E-value: 1.19e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 9 MPKTEFPMRGNLPKREPAMQEKWAEMNIYETvqEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFcA 88
Cdd:PRK13208 1 KMMPELPKKYDPEELEEKWQKIWEEEGTYKF--DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGY-N 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 89 PYVP-GWDTHGLPIEQALTNK-GVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKV 166
Cdd:PRK13208 78 VFFPqGWDDNGLPTERKVEKYyGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 167 FGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIYVAFSVKDGKNVlegdekyIIWTTTPWTLPANLGISVH 246
Cdd:PRK13208 158 FLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDGEEI-------EIATTRPELLPACVAVVVH 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 247 PEleyaivkvnDEKYiiaSELFETVAKT-LEweNAEVvktvkgseleyTVAKHPFYDRD---SLVML---GDhvttdagt 319
Cdd:PRK13208 231 PD---------DERY---KHLVGKTAIVpLF--GVEV-----------PILADPLVDPDfgtGAVMIctfGD-------- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 320 gcvhtapghgEDDFIVGKKYGLEVLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTK 399
Cdd:PRK13208 278 ----------KTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCD 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 400 KPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNMVRD-RGDWCISRQRAWGVPIPVFYAEN-GDPIITDEt 477
Cdd:PRK13208 348 TPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMRVRLENWIEGlNWDWCISRQRYFGTPIPVWYCKDcGHPILPDE- 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 478 inhvADLfrehgsNVwfeREAKDLlPEGFTHPGSPNGEFRKETDIMDVWFDSGSSHQAVL--EERDDLQR---PADLYLE 552
Cdd:PRK13208 427 ----EDL------PV---DPTKDE-PPGYKCPQCGSPGFEGETDVMDTWATSSITPLIVTgwERDEDLFEkvfPMDLRPQ 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 553 GSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRIS 632
Cdd:PRK13208 493 GHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRYWAASARLGSDTPFD 572
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 633 DDILKQVAEVYRKIRNTFRFLLgNLDDFKPSENtvaVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTI 712
Cdd:PRK13208 573 EKQVKIGRRLLTKLWNASRFVL-HFSADPEPDK---AEVLEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFFWH 648
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 713 DLSSFYLDFAKDILYIEGANHEDRRAIQTvLYDVLVALTKLVTPILPHTADEVWPYIPGvteESVQLTDMPEAVQLDDAE 792
Cdd:PRK13208 649 VFCDDYLELVKSRAYGEDEEEEQKSARYT-LYTVLDTLLRLLAPFLPFITEEVWSWLYG---GSVHRASWPEPDEELIDE 724
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 793 ALKTKWDAFMtlrdDVLKALEVARNEKviGKSLNASI---TLYPTAEMKAmLESINEDLK 849
Cdd:PRK13208 725 EDEELGELAK----EILSAVRKYKSEA--GLSLNAPLkkvEVYGPADLEL-LEAAEEDLK 777
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
24-867 |
1.30e-144 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 450.66 E-value: 1.30e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 24 EPAMQEKWAEMNIYETVQEHTKgrPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLP--- 100
Cdd:TIGR00422 11 EKKWYKKWEKSGFFKPDGNSNK--PPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIAtqv 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 101 -IEQALTNKGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKG 179
Cdd:TIGR00422 89 kVEKKLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLIYRG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 180 QKPVYWSPTSESALAEAEIEYQDKKSASIYVAFSVKDGKNvlegdEKYIIWTTTPWTLPANLGISVHPEleyaivkvnDE 259
Cdd:TIGR00422 169 EYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGSK-----DYLVVATTRPETMFGDTAVAVHPE---------DE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 260 KYiiaselfetvaKTLewenaeVVKTVKgseleytvakHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKY 339
Cdd:TIGR00422 235 RY-----------KHL------IGKKVI----------LPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRH 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 340 GLEVLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRK 419
Cdd:TIGR00422 288 NLEFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLAD 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 420 ELLEAV--AETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYaengdpiiTDETIN-HVADlfrehgsNVWFER 496
Cdd:TIGR00422 368 KALEAAeeGEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWY--------CKECGEvYVAK-------EEPLPD 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 497 EAKDLlpegfthpgSPNGEFRKETDIMDVWFDSGSSHQAVL---EERDDLQR--PADLYLEGSDQYRGWFNSSLSTAVAV 571
Cdd:TIGR00422 433 DKTNT---------GPSVELEQDTDVLDTWFSSSLWPFSTLgwpDETKDLKKfyPTDLLVTGYDIIFFWVARMIFRSLAL 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 572 TGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSS-VDYQSDVRISDDILKQVAEVYRKIRNTF 650
Cdd:TIGR00422 504 TGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASlVTPGDDINFDWKRVESARNFLNKLWNAS 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 651 RFLLGNLDDFKPSENTvaVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYieG 730
Cdd:TIGR00422 584 RFVLMNLSDDLELSGG--EEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELVKYRLY--N 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 731 ANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGvTEESVQLTDMPEAV-QLDDAEALKtkwdafmtLRDDVL 809
Cdd:TIGR00422 660 GNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKE-GADSIMLQSYPVVDaEFVDEEAEK--------AFELLK 730
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81583658 810 KALEVARNEKV-IGKSLNASITL---YPTAEMKAMLESINEDLKQLFIVSEYKLGGMMEEAP 867
Cdd:TIGR00422 731 EIIVSIRNLKAeSNIPPNAPLKVlliYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVT 792
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
19-856 |
8.97e-133 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 427.22 E-value: 8.97e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 19 NLPKREPAMQEKWAEMNIYETVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHG 98
Cdd:PLN02882 9 SFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 99 LPIEQALTNK-GVKRKE----MTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKK 173
Cdd:PLN02882 89 LPVEYEIDKKlGIKRRDdvlkMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 174 GYIYKGQKPVYWSPTSESALA--EAEIEYQDKKSASIYVAFS-VKDGKNVlegdeKYIIWTTTPWTLPANLGISVHPELE 250
Cdd:PLN02882 169 GLVYKGFKVMPYSTACKTPLSnfEAGLNYKDVSDPAVMVSFPiVGDPDNA-----SFVAWTTTPWTLPSNLALCVNPNFT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 251 YAIVKVNDEK--YIIA----SELFETVAKTLEWENA-------EVVKTVKGSELeytVAKH-----PFYDRDS----LVM 308
Cdd:PLN02882 244 YVKVRNKYTGkvYIVAesrlSALPTAKPKSKKGSKPenaaegyEVLAKVPGSSL---VGKKyeplfDYFSEFSdtafRVV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 309 LGDHVTTDAGTGCVHTAPGHGEDDF-------IVGKkyGLEVLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGA 381
Cdd:PLN02882 321 ADDYVTDDSGTGVVHCAPAFGEDDYrvclangIIEK--GGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 382 LLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAETKWVPAW-GETRLHNMVRDRGDWCISRQRAWGVP 460
Cdd:PLN02882 399 LVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYvKEKRFHNWLENARDWAVSRSRFWGTP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 461 IPVFYAENGDPIItdeTINHVADLFREHGSNVW-FEREAKDLLpegfTHPGSPNGEF---RKETDIMDVWFDSGSSHQAV 536
Cdd:PLN02882 479 LPIWISDDGEEVV---VIGSIAELEKLSGVKVTdLHRHFIDHI----TIPSSRGPEFgvlRRVDDVFDCWFESGSMPYAY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 537 L----EERDDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQ 610
Cdd:PLN02882 552 IhypfENKELFEKnfPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDK 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 611 LGGDILRLWV--SSVDYQSDVRISDD-ILKQVAEVYRKIRNTFRFLLGN--------LDDFKPSENTVAVAELREVDRYM 679
Cdd:PLN02882 632 YGADALRLYLinSPVVRAEPLRFKEEgVFGVVKDVFLPWYNAYRFLVQNakrlevegGAPFVPLDLAKLQNSANVLDRWI 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 680 LVKLNDLITKVKEAYETYDFAAVYHAIHNFCTiDLSSFYLDFAKDILYIEGANHEDRRAIQTvLYDVLVALTKLVTPILP 759
Cdd:PLN02882 712 NSATQSLVKFVREEMGAYRLYTVVPYLVKFID-NLTNIYVRFNRKRLKGRTGEEDCRTALST-LYNVLLTSCKVMAPFTP 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 760 HTADEVWPYIPGV---TEESVQLTDMPEAVQLDDAEALKTKWDAFMTLRDDVLKALEvaRNEKVIGKSLNASITLYPTAE 836
Cdd:PLN02882 790 FFTEVLYQNLRKVlpgSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRE--RHNKPLKTPLKEMVVVHPDAE 867
|
890 900
....*....|....*....|
gi 81583658 837 mkaMLESINEDLKQlFIVSE 856
Cdd:PLN02882 868 ---FLDDITGKLKE-YVLEE 883
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
48-631 |
4.92e-118 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 363.09 E-value: 4.92e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 48 PLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNK-GVK----RKEMTVAEFRK 122
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKElGISgkkdIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 123 LCAEYAYEQVERQREQFKRLGvradwdnpyitlepayeaqqikVFGDMaKKGYIykgqkpvywsptsesalaeaeieyqd 202
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLG----------------------VWVDW-ENPYK-------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 203 kksasiyvafsvkdgknvlegdekyiiwtttpwTLpanlgisvhpeleyaivkvnDEKYIIAselfetvaktlEWEnaeV 282
Cdd:cd00818 112 ---------------------------------TM--------------------DPEYMES-----------VWW---V 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 283 VKTvkgseleytvakhpFYDRdslvmlgdhvttdagtgcvhtapghgeddfivgkkyglevlcpvddkgvlteeapgfeG 362
Cdd:cd00818 125 FKQ--------------LHEK----------------------------------------------------------G 132
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 363 LFYdKANKPITekleevgallkltfithsyphdWrtkkPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNM 442
Cdd:cd00818 133 LLY-RGYKVVP----------------------W----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNRFGNW 185
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 443 VRDRGDWCISRQRAWGVPIPVFYAENGDPIITdetinhvadlfrehgsnvwfereakdllpegfthpgspngefRKETDI 522
Cdd:cd00818 186 LENRRDWCISRQRYWGTPIPVWYCEDCGEVLV------------------------------------------RRVPDV 223
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 523 MDVWFDSGSSHQAVL---EERDDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKS 597
Cdd:cd00818 224 LDVWFDSGSMPYAQLhypFENEDFEElfPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKS 303
|
570 580 590
....*....|....*....|....*....|....*
gi 81583658 598 IGNIVVPKKIMDQLGGDILRLWVSSVD-YQSDVRI 631
Cdd:cd00818 304 LGNYVDPQEVVDKYGADALRLWVASSDvYAEDLRF 338
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
19-850 |
2.55e-108 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 361.98 E-value: 2.55e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 19 NLPKREPAMQEKWAEMNIYETVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHG 98
Cdd:PTZ00427 73 NIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 99 LPIEQALTNKG-VKRKE----MTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKK 173
Cdd:PTZ00427 153 LPIEYEIEKENnINKKEdilkMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKN 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 174 GYIYKGQKPVYWSPTSESALA--EAEIEYQDKKSASIYVAF-------SVKDGKNVLE---------------------- 222
Cdd:PTZ00427 233 NYVYKSFKVMPYSCKCNTPISnfELNLNYKDTPDPSIIISFvlcsdfpKVEEECNIEEdkqllgekysvlynnkrensnn 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 223 ------------GDEKYIIWTTTPWTLPANLGISVHPELEY-AIVKVNDEKYIIASEL-FETVAKTLEW--ENAEVVKTV 286
Cdd:PTZ00427 313 gnnnstnnvcyaQHSEILAWTTTPWTLPSNLALCVNEHFTYlRIHHVKSNRVVIVGECrLEWIMKELKWnvEDLKIVNRF 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 287 KGSELE---------YTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLE------VLCPVDDKG 351
Cdd:PTZ00427 393 KGKELKglrykplftNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIdpekniFIDPLDANG 472
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 352 VLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAETKWV 431
Cdd:PTZ00427 473 YFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWI 552
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 432 PAW-GETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDPIITDETINH---------VADLFREHGSNVWFEReakdl 501
Cdd:PTZ00427 553 PAHiKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHleelsgvknINDLHRHFIDHIEIKN----- 627
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 502 lPEGFTHPgspngEFRKETDIMDVWFDSGSS-----HQAVLEERDDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGK 574
Cdd:PTZ00427 628 -PKGKTYP-----KLKRIPEVFDCWFESGSMpyakvHYPFSTEKEDFHKifPADFIAEGLDQTRGWFYTLLVISTLLFDK 701
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 575 APYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLW-VSSVDYQSD-VRISDdilKQVAEVYRKI----RN 648
Cdd:PTZ00427 702 APFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYlINSVAVRAEnLKFQE---KGVNEVVKSFilpfYH 778
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 649 TFRFLLGNLDDFKPSE------NTVAVAELREV-DRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTiDLSSFYLDF 721
Cdd:PTZ00427 779 SFRFFSQEVTRYECLNkkqflfNTDYIYKNDNImDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIE-NLTNWYIRL 857
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 722 AKDILYIEGANHEDRRAIQTvLYDVLVALTKLVTPILPHTADEVWPYIP------------------------GVTEESV 777
Cdd:PTZ00427 858 NRDRMRGSLGEENCLQSLCT-TYRTLHLFTVLMAPFTPFITEYIYQQLRrvkstnehnennetgntkegdlnrGVIHKSV 936
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81583658 778 QLTDMPeavQLDDAEALKtkwDAFMTLRDDVLKALEVARN----EKVIGKSLNASIT-LYPTAEMKAMLESINEDLKQ 850
Cdd:PTZ00427 937 HFIMLP---QVDEKYIID---YEIIELIEKMKDVILLGRVlrerRKVASKKPLKSITiLHPNESYFKNFDQISNYIKE 1008
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
56-903 |
2.89e-105 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 346.71 E-value: 2.89e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 56 PPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGlpI------EQALTNKGVKRKEMTVAEFRKLCAEYAY 129
Cdd:PRK05729 44 PPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTDHAG--IatqmvvERQLAAEGKSRHDLGREKFLEKVWEWKE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 130 EQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIY 209
Cdd:PRK05729 122 ESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWH 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 210 VAFSVKDGKNVLEgdekyiIWTTTPWTLPANLGISVHPEleyaivkvnDEKYiiaselfetvaKTLewenaeVVKTVKgs 289
Cdd:PRK05729 202 IRYPLADGSDYLV------VATTRPETMLGDTAVAVNPE---------DERY-----------KHL------IGKTVI-- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 290 eleytvakHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEAPGFEGLFYDKAN 369
Cdd:PRK05729 248 --------LPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEYQGLDRFEAR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 370 KPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVA--ETKWVPAWGETRLHNMVRDRG 447
Cdd:PRK05729 320 KAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVEngEIKFVPERWEKTYFHWMENIQ 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 448 DWCISRQRAWGVPIPVFYAENGdpiitdetinhvadlfrehgsNVWFEREAKDLLPegfthpgspNGEFRKETDIMDVWF 527
Cdd:PRK05729 400 DWCISRQLWWGHRIPAWYDEDG---------------------EVYVGREEPEARE---------KALLTQDEDVLDTWF 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 528 DSGsshqavL---------EERDDLQR--PadlylegsdqyrgwfNSSLSTA-------VA--------VTGKAPYKGVL 581
Cdd:PRK05729 450 SSA------LwpfstlgwpEKTEDLKRfyP---------------TSVLVTGfdiiffwVArmimmglhFTGQVPFKDVY 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 582 SHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQ-SDVRISDDILKQvaevYR----KIRNTFRFLLGN 656
Cdd:PRK05729 509 IHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPgRDIRFDEERVEG----YRnfanKLWNASRFVLMN 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 657 LDDFKPSENTvAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYieganHEDR 736
Cdd:PRK05729 585 LEGADVGELP-DPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQ-----EAAK 658
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 737 RAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGV-TEESVQLTDMPEAVQLDDAEALKtKWDAFMtlrdDVLKALEVA 815
Cdd:PRK05729 659 RATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLgIEESIMLAPWPEADEAIDEAAEA-EFEWLK----ELITAIRNI 733
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 816 RNEKVIGKSLNASITLY-PTAEMKAMLESINEDLKQLFIVSEYKLGGMMEEAPADAPkyehTAVVvaqatgETCERCWVV 894
Cdd:PRK05729 734 RAEMNIPPSKKLPLLLKgADAEDRARLEANEAYIKRLARLESLEILADDEEAPEGAA----SAVV------GGAELFLPL 803
|
....*....
gi 81583658 895 SETIGKDAE 903
Cdd:PRK05729 804 EGLIDVEAE 812
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
56-879 |
3.42e-99 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 330.48 E-value: 3.42e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 56 PPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDtH-GlpI------EQALTNKGVKRKEMTVAEFrkLcaEYA 128
Cdd:COG0525 43 PPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD-HaG--IatqavvERQLAEEGKSRHDLGREKF--L--ERV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 129 YEQVERQ----REQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKK 204
Cdd:COG0525 116 WEWKEESggtiTNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 205 SASIYVAFSVKDGKNVLegdekyIIWTTTPWTLPANLGISVHPEleyaivkvnDEKYiiaselfetvaKTLewenaeVVK 284
Cdd:COG0525 196 GHLWHIRYPLADGSGYI------VVATTRPETMLGDTAVAVHPE---------DERY-----------KHL------IGK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 285 TVKgseleytvakHPFYDR------DslvmlgDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEAP 358
Cdd:COG0525 244 TVI----------LPLVGReipiiaD------EYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 359 GFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVA--ETKWVPA-WG 435
Cdd:COG0525 308 KYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEdgEIKFVPErWE 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 436 ETRLHNM--VRDrgdWCISRQRAWGVPIPVFYAENGdpiitdetinhvadlfrehgsNVWFEREAKDLLPEgfthpgSPN 513
Cdd:COG0525 388 KTYFHWMenIRD---WCISRQLWWGHRIPAWYCPDG---------------------EVYVARTEPEACAK------AGS 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 514 GEFRKETDIMDVWFDSG----SshqaVL---EERDDLQRpadlYLEGSDqyrgwfnssLSTA-------VA--------V 571
Cdd:COG0525 438 VNLTQDEDVLDTWFSSAlwpfS----TLgwpEKTEDLKY----FYPTSV---------LVTGfdiiffwVArmimmglhF 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 572 TGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRL-WVSSVDYQSDVRISDDILKQvaevYR----KI 646
Cdd:COG0525 501 TGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFtLAALASPGRDIKFDEERVEG----YRnfanKL 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 647 RNTFRFLLGNLDDFKPSENtVAVAELREVDRYMLVKLNDLITKVKEAYETYDFA----AVYHAI-HNFCtidlsSFYLDF 721
Cdd:COG0525 577 WNASRFVLMNLEGFDPGLD-PDPEELSLADRWILSRLNKTIAEVTEALEKYRFDeaaqALYDFVwNEFC-----DWYLEL 650
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 722 AKDILYieGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIP-GVTEESVQLTDMPEAV-QLDDAEALKtkwd 799
Cdd:COG0525 651 AKPRLY--GGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPpRKEGESIMLAPWPEADeELIDEEAEA---- 724
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 800 AFMTLRdDVLKALEVARNEKVIGKSLNASITLY-PTAEMKAMLESINEDLKQLFIVSEYKLGGmmEEAPADAPkyehTAV 878
Cdd:COG0525 725 EFEWLK-EVISAIRNIRAEMNIPPSKKLPLLLKgADEADRARLEENAAYIKRLARLEEITILV--DEKPEGAA----SAV 797
|
.
gi 81583658 879 V 879
Cdd:COG0525 798 V 798
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
631-809 |
6.75e-95 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 296.36 E-value: 6.75e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 631 ISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENTVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFC 710
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 711 TIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVT-EESVQLTDMPEAVQLD 789
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKkEESVFLEDWPELPEEW 160
|
170 180
....*....|....*....|
gi 81583658 790 DAEALKTKWDAFMTLRDDVL 809
Cdd:cd07960 161 KDEELEEKWEKLLALRDEVN 180
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
31-793 |
2.58e-91 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 312.70 E-value: 2.58e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 31 WAEMNiYETVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLP----IEQALT 106
Cdd:PRK14900 32 WQERG-YFHGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIAtqmiVEKELK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 107 N-KGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYW 185
Cdd:PRK14900 111 KtEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINW 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 186 SPTSESALAEAEIEYQDKKSASIY-VAFSVKDGknvlegDEKYIIWTTTPWTLPANLGISVHPEleyaivkvnDEKYiia 264
Cdd:PRK14900 191 CPDCRTALSDLEVEHEEAHQGELWsFAYPLADG------SGEIVVATTRPETMLGDTAVAVHPL---------DPRY--- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 265 selfetvaktleweNAEVVKTVKgseleytvakHPFYDRDsLVMLGDHVTTDA--GTGCVHTAPGHGEDDFIVGKKYGLE 342
Cdd:PRK14900 253 --------------MALHGKKVR----------HPITGRT-FPIVADAILVDPkfGTGAVKVTPAHDFNDFEVGKRHGLE 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 343 VLCPVDDKGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKltfithSYPHDW------RTKKPIIFRATAQWFASIEA 416
Cdd:PRK14900 308 MITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRG------AKPHVLplgrcqRSATILEPLLSDQWYVRIEP 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 417 FRKELLEAVAE--TKWVP-AWGETRLHNMvRDRGDWCISRQRAWGVPIPVFYAENGDPIITDETinhvadlfrehgsnvw 493
Cdd:PRK14900 382 LARPAIEAVEQgrTRFIPeQWTNTYMAWM-RNIHDWCISRQLWWGHQIPAWYCPDGHVTVARET---------------- 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 494 fereakdllPEGFTHPGSpnGEFRKETDIMDVWFDSG---SSHQAVLEERDDLQR--PADLYLEGSDQYRGWFNSSLSTA 568
Cdd:PRK14900 445 ---------PEACSTCGK--AELRQDEDVLDTWFSSGlwpFSTMGWPEQTDTLRTfyPTSVMETGHDIIFFWVARMMMMG 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 569 VAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQS-DVRISDDILKQVAEVYRKIR 647
Cdd:PRK14900 514 LHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGrDIKLAKERIEGYRAFANKLW 593
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 648 NTFRFLLGNLDDFKPSENTVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILY 727
Cdd:PRK14900 594 NASRFALMNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEALA 673
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81583658 728 ieGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIP-----GVTEESVQLTDMPEAVQLDD-AEA 793
Cdd:PRK14900 674 --SEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRaqvgaSAWADSVLAAEYPRKGEADEaAEA 743
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
44-875 |
7.18e-82 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 284.53 E-value: 7.18e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 44 TKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHG----LPIEQALTNKGVKRKEMTVAE 119
Cdd:PLN02943 84 DRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGiatqLVVEKMLASEGIKRTDLGRDE 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 120 FRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIE 199
Cdd:PLN02943 164 FTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVE 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 200 YQDKKSASIYVAFSVKDGKnvlegDEKYIIWTTTPWTLPANLGISVHPEleyaivkvnDEKYIiaselfETVAKTlewen 279
Cdd:PLN02943 244 YSEEPGTLYYIKYRVAGGS-----EDFLTIATTRPETLFGDVAIAVNPE---------DDRYS------KYIGKM----- 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 280 AEVVKTvkgseleytvakhpfYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEApg 359
Cdd:PLN02943 299 AIVPMT---------------YGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVA-- 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 360 feGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAV--AETKWVPAWGET 437
Cdd:PLN02943 362 --GLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVenGELTIIPERFEK 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 438 RLHNMVRDRGDWCISRQRAWGVPIPVFYAENGD---PIITDETINHVADLFRE-HGSNVwfereakdllpegfthpgspn 513
Cdd:PLN02943 440 IYNHWLSNIKDWCISRQLWWGHRIPVWYIVGKDceeDYIVARSAEEALEKAREkYGKDV--------------------- 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 514 gEFRKETDIMDVWFDSGSSHQAVL----EERDDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVL 587
Cdd:PLN02943 499 -EIYQDPDVLDTWFSSALWPFSTLgwpdVSAEDFKKfyPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIR 577
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 588 DGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNL---DDFKPSE 664
Cdd:PLN02943 578 DSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLSTERLTSNKAFTNKLWNAGKFVLQNLpsqSDTSAWE 657
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 665 NTVA--------VAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHEDR 736
Cdd:PLN02943 658 HILAckfdkeesLLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKTRLYHSGDNSALS 737
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 737 RAiQTVLYDVLVALTKLVTPILPHTADEVWPYIPGvTEESVQLTDMPEAVQLDDAEALKtKWDAFMTLrddvLKALEVAR 816
Cdd:PLN02943 738 RA-QAVLLYVFENILKLLHPFMPFVTEELWQALPY-RKEALIVSPWPQTSLPKDLKSIK-RFENLQSL----TRAIRNAR 810
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81583658 817 NEKVIGKSLNASITLYPTAEmkaMLESINEDLKQLFIVSEYKLGGM--MEEAPADAPKYEH 875
Cdd:PLN02943 811 AEYSVEPAKRISASIVASAE---VIEYISKEKEVLALLSRLDLQNVhfTDSPPGDANQSVH 868
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-852 |
7.80e-82 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 284.98 E-value: 7.80e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 1 MEYKNTLLMPKTEFPMRGNLPKREPAMQEKWAEMNIYE-----------TVQEHTKGRPLFVLHDGPPYANGDIHMGHAL 69
Cdd:PTZ00419 2 MKKEEIKLSKDEKKNKKRNISSMAASYDPKEVESGWYEwweksgffkpaEDAKSLNSGKKFVIVLPPPNVTGYLHIGHAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 70 NKVLKDFIVRYKSMTGFCAPYVPGWDTHGLP----IEQALTNK-GVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGV 144
Cdd:PTZ00419 82 TGAIQDSLIRYHRMKGDETLWVPGTDHAGIAtqvvVEKKLMKEeNKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 145 RADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQD-KKSASI--------------- 208
Cdd:PTZ00419 162 SLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEiEKPTKItipgydkkvevgvlw 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 209 YVAFSVKDGknvleGDEKYIIWTTTPWTLPANLGISVHPeleyaivkvNDEKYiiaselfetvaktlewenaevvKTVKG 288
Cdd:PTZ00419 242 HFAYPLEDS-----GQEEIVVATTRIETMLGDVAVAVHP---------KDERY----------------------KKLHG 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 289 SELeytvaKHPFY-DRDSLVMLGD-HVTTDAGTGCVHTAPGHGEDDFIVGKKYGLEVLCPVDDKGVLTEEAPGFEGLFYD 366
Cdd:PTZ00419 286 KEL-----IHPFIpDRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRF 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 367 KANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELLEAV--AETKWVPAWGETRLHNMVR 444
Cdd:PTZ00419 361 DCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVrnGELKIIPSSHENVWYHWLE 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 445 DRGDWCISRQRAWGVPIPVFY--AENGDPIITDETINHVADLFREHGSNVwfeREAKDLLPEGFthpgspngEFRKETDI 522
Cdd:PTZ00419 441 NIQDWCISRQLWWGHRIPAYRviSKGPETDPSDEEPWVVARSEEEALEKA---KKKFGLSEEDF--------ELEQDEDV 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 523 MDVWFDSGSSHQAVL---EERDDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKS 597
Cdd:PTZ00419 510 LDTWFSSGLFPFSTLgwpDQTDDLQRffPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKS 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 598 IGNIVVPKKIMD-------------------------------------QLGGDILRLWVSSvdYQSDVR-ISDDILKQV 639
Cdd:PTZ00419 590 KGNVIDPLEVIEgislqdlnqklyegnlpekeikraielqkkefpngipECGTDALRFGLLA--YTQQGRnINLDINRVV 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 640 AevYR----KIRNTFRFLLGNLDDFKPSENTVAVAELRE-----VDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFC 710
Cdd:PTZ00419 668 G--YRhfcnKLWNAVKFALMKLLKDFNLPNSTLFKPNNVeslpwEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFW 745
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 711 TIDLSSFYLDFAKDILyIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVTE--ESVQLTDMPEAVQL 788
Cdd:PTZ00419 746 LYELCDVYLELIKPRL-SKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRksESISIAKYPQPNPG 824
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81583658 789 DDAEALKTKWDAFMtlrdDVLKALevarnekvigKSLNASITLYPTAEMKAMLESINEDLKQLF 852
Cdd:PTZ00419 825 WNNEALDEEMKIIM----SIVKSI----------RSLIATLGIPNKTKPDCYVTAKDAELIELI 874
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
56-636 |
1.57e-73 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 246.77 E-value: 1.57e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 56 PPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLP----IEQALTNKGVKRKEMTVAEFRKLCAEYAYEQ 131
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIAtqvvVEKKLGIEGKTRHDLGREEFLEKCWEWKEES 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 132 VERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYqdkksasiyva 211
Cdd:cd00817 89 GGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEVCS----------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 212 fsvkDGKNVLEgdekyiiwtttpwtlpanlgisvhpeleyaivkvndekyiiaselfetvaktlewenaevvktvkgsel 291
Cdd:cd00817 158 ----RSGDVIE--------------------------------------------------------------------- 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 292 eytvakhpfydrdslvmlgdhvttdagtgcvhtapghgeddfivgkkyglevlcpvddkgvlteeapgfeglfydkankP 371
Cdd:cd00817 165 -------------------------------------------------------------------------------P 165
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 372 ITEKleevgallkltfithsyphdwrtkkpiifrataQWFASIEAFRKELLEAVAE--TKWVPAWGETRLHNMVRDRGDW 449
Cdd:cd00817 166 LLKP---------------------------------QWFVKVKDLAKKALEAVKEgdIKFVPERMEKRYENWLENIRDW 212
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 450 CISRQRAWGVPIPVFYAENGDPIITDETinhvadlfrehgsnvwfEREAKDLLPEGFTHPGSPNgEFRKETDIMDVWFDS 529
Cdd:cd00817 213 CISRQLWWGHRIPAWYCKDGGHWVVARE-----------------EDEAIDKAAPEACVPCGGE-ELKQDEDVLDTWFSS 274
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 530 GSSHQAVL---EERDDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVP 604
Cdd:cd00817 275 SLWPFSTLgwpEETKDLKKfyPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDP 354
|
570 580 590
....*....|....*....|....*....|..
gi 81583658 605 KKIMDQLGGDILRLWVSSVdyqsdVRISDDIL 636
Cdd:cd00817 355 LDVIDGYGADALRFTLASA-----ATQGRDIN 381
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
50-631 |
2.52e-63 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 216.52 E-value: 2.52e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 50 FVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKEMT-VAEFRKLCAEYA 128
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIwIEEFREDPKEFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 129 YEQVERQreqfkrlgvRADWDNpyitlepayeaqqikvfgdmakkgyiykgqkpvywsptsesalaeaeieyqdkksasi 208
Cdd:cd00668 82 EEMSGEH---------KEDFRR---------------------------------------------------------- 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 209 yvafsvkdgknvlegdekyiiwtttpwtlpanLGISVHPELEYAivkvndekyiiaselfetvakTLEWENAEVVktvkg 288
Cdd:cd00668 95 --------------------------------LGISYDWSDEYI---------------------TTEPEYSKAV----- 116
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 289 sELEYTVAKHpfydrdslvmlgdhvttdagtgcvhtapghgeddfivgkkyglevlcpvddkgvlteeapgfEGLFYdka 368
Cdd:cd00668 117 -ELIFSRLYE--------------------------------------------------------------KGLIY--- 130
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 369 nkpitekleevgallkltfithsyphdwrtKKPIIFRATAQWFASIEAFRKELLEAVAETKWVPAWGETRLHNMVRDRGD 448
Cdd:cd00668 131 ------------------------------RGTHPVRITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWLESLLD 180
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 449 WCISRQRAWGVPIPvfyaengdpiitdetinhvadlfrehgsnvwfereakdllpegfthpgspngefrkeTDIMDVWFD 528
Cdd:cd00668 181 WAISRQRYWGTPLP---------------------------------------------------------EDVFDVWFD 203
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 529 SGSSHQAVLEERDDLQR-----PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVV 603
Cdd:cd00668 204 SGIGPLGSLGYPEEKEWfkdsyPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVID 283
|
570 580
....*....|....*....|....*....
gi 81583658 604 PKKIMDQLGGDILRLWV-SSVDYQSDVRI 631
Cdd:cd00668 284 PSDVVEKYGADALRYYLtSLAPYGDDIRL 312
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
47-869 |
1.66e-57 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 214.76 E-value: 1.66e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 47 RPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKEMT---------V 117
Cdd:PLN02381 127 KPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTrhdigreefV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 118 AEFRKLCAEYAYEQVErqreQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAE 197
Cdd:PLN02381 207 SEVWKWKDEYGGTILN----QLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVE 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 198 IEYQDKKSASIY--------VAFSVKDG-KNVLEGDEKYIIWTTTPW-TLPANLGISVHPEleyaivkvnDEKYiiasel 267
Cdd:PLN02381 283 VDYIDIKERTLLkvpgydkpVEFGVLTSfAYPLEGGLGEIVVATTRIeTMLGDTAIAIHPD---------DERY------ 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 268 fetvaktlewenaevvktvkgSELEYTVAKHPFYDRdSLVMLGDHVTTDA--GTGCVHTAPGHGEDDFIVGKKYGLEVLC 345
Cdd:PLN02381 348 ---------------------KHLHGKFAVHPFNGR-KLPIICDAILVDPnfGTGAVKITPAHDPNDFEVGKRHNLEFIN 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 346 PVDDKGVL-TEEAPGFEGLFYDKANKPITEKLEEVGAL-------LKLTFITHSYphdwRTKKPIIfraTAQWFASIEAF 417
Cdd:PLN02381 406 IFTDDGKInSNGGSEFAGMPRFAAREAVIEALQKKGLYrgaknneMRLGLCSRTN----DVVEPMI---KPQWFVNCSSM 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 418 RKELLEAVAETK-----WVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDpiitdetinhvaDLFREHGSNV 492
Cdd:PLN02381 479 AKQALDAAIDGEnkkleFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLED------------DQLKELGSYN 546
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 493 --WF-EREAKDLLPEGFTHPGSPNGEFRKETDIMDVWFDSGSSHQAVL---EERDDLQR--PADLYLEGSDQYRGWFNSS 564
Cdd:PLN02381 547 dhWVvARNESDALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLgwpDDTDDLKAfyPTSVLETGHDILFFWVARM 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 565 LSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMD----------------------------------- 609
Cdd:PLN02381 627 VMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINgisleglhkrleegnldpkelvvakegqkkdfpng 706
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 610 --QLGGDILRLWVSSVDYQSDvRISDDILKQVAevYR----KIRNTFRFLLGNLDDFKPSENTVAVAELREVDRYMLVKL 683
Cdd:PLN02381 707 iaECGTDALRFALVSYTAQSD-KINLDILRVVG--YRqwcnKLWNAVRFAMSKLGDDYTPPATLSVETMPFSCKWILSVL 783
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 684 NDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDilYIEGANHE---DRRAIQTVLYDVLVALTKLVTPILPH 760
Cdd:PLN02381 784 NKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKP--YFAGDNPEfasERAAAQDTLWICLDTGLRLLHPFMPF 861
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 761 TADEVWPYIPGVT----EESVQLTDMPEAVQLDDAEALKTKwdafMTLRDDVLKALEVARNEkVIGKSLNASITLYPTAE 836
Cdd:PLN02381 862 VTEELWQRLPQPKdhtrKDSIMISEYPSAVEAWTNEKVEYE----MDLVLSTVKCLRSLRAE-VLEKQKNERLPAFALCR 936
|
890 900 910
....*....|....*....|....*....|....*....
gi 81583658 837 MKAMLESINEdlKQLFIVSEYKLGGMM------EEAPAD 869
Cdd:PLN02381 937 NQEIAAIIKS--HQLEILTLANLSSLKvllsenDAPPAG 973
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
24-766 |
4.36e-46 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 179.25 E-value: 4.36e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 24 EPAMQEKWAEMNIYETVQEHTKGRPLFVLHDGPPYANG-DIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIE 102
Cdd:PLN02563 86 EPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGaGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAE 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 103 QALTNKGVKRKEMTVAefrklcaeyayeQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKP 182
Cdd:PLN02563 166 QYAIETGTHPKITTLK------------NIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVP 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 183 VYWSPTSESALAEAEI-------------------------EYQDK-----------------------KSASIYVAFSV 214
Cdd:PLN02563 234 VNWCPALGTVLANEEVvdglsergghpvirkpmrqwmlkitAYADRlledlddldwpesikemqrnwigRSEGAELDFSV 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 215 KDGkNVLEGDEKYIIWTTTPWTLPANLGISVHPELEYAIVKVNDEKYIIASELFETVAKTLEWENAEVVKtVKGSELEYT 294
Cdd:PLN02563 314 LDG-EGKERDEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRKSDLERTELQK-EKTGVFTGS 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 295 VAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLE---VLCPVDDKGVLTEEA---PG--------- 359
Cdd:PLN02563 392 YAINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPikwVVKPADGNEDDAEKAytgEGvivnssssg 471
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 360 --FEGLFYDKANKPITEKLEEVGAllkltfithsyphdwrtkkpiifrataqwfasieafrkelleavaetkwvpawGET 437
Cdd:PLN02563 472 ldINGLSSKEAAKKVIEWLEETGN-----------------------------------------------------GKK 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 438 RLHNMVRdrgDWCISRQRAWGVPIPVFYAENGD---PIITDETINHVADL--FREHGSNVWFEREAKDLLPEGFTHPGSP 512
Cdd:PLN02563 499 KVNYKLR---DWLFARQRYWGEPIPVVFLEDSGepvPVPESDLPLTLPELddFTPTGTGEPPLAKAVSWVNTVDPSSGKP 575
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 513 ngeFRKETDIMDVW----------FDSGSSHQAVLEERDDLQRPADLYLEGSDQ------YRGWFNSSLSTAVAVTGKAP 576
Cdd:PLN02563 576 ---ARRETNTMPQWagscwyylrfMDPKNSNALVDKEKEKYWMPVDLYVGGAEHavlhllYARFWHKVLYDIGVVSTKEP 652
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 577 YKGVLSHGFVL---------DGEGR---------------------------------------------KMSKSIGNIV 602
Cdd:PLN02563 653 FQCLVNQGMILgeveytafkDSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVV 732
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 603 VPKKIMDQLGGDILRLWVSSVDYQSDVRISDDilKQVAEVYRKIRNTFRFLLGN-LDDFKPSENTVAVAElrEVDRYMLV 681
Cdd:PLN02563 733 NPDDVVSEYGADSLRLYEMFMGPLRDSKTWST--SGVEGVHRFLGRTWRLVVGApLPDGSFRDGTVVTDE--EPSLEQLR 808
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 682 KLNDLITKVKEAYETYDFAAVYHAIHNFctidlssfyldfakdilyIEGANHEDRRAIQtvlydVLVALTKLVTPILPHT 761
Cdd:PLN02563 809 LLHKCIAKVTEEIESTRFNTAISAMMEF------------------TNAAYKWDKVPRE-----AIEPFVLLLSPYAPHL 865
|
....*
gi 81583658 762 ADEVW 766
Cdd:PLN02563 866 AEELW 870
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
24-795 |
1.14e-41 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 164.45 E-value: 1.14e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 24 EPAMQEKWAEMNIYETVQEHTKgRPLFVLhDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFcapYV--P-GWDTHGLP 100
Cdd:COG0495 11 EKKWQKYWEENGTFKADEDSSK-PKYYVL-DMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGY---NVlhPmGWDAFGLP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 101 IEQALTNKGVKRKEMTvaefrklcaeyaYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQ 180
Cdd:COG0495 86 AENAAIKNGVHPAEWT------------YENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 181 KPVYWSPTSESALA------------EAEIE-------------YQDK------------------------KSASIYVA 211
Cdd:COG0495 154 APVNWCPVDQTVLAneqvidgrcwrcGAPVEkkelpqwflkitdYADEllddldkldgwpekvktmqrnwigRSEGAEVD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 212 FSVKDGKNVLEgdekyiIWTTTPWTLpanLGIS---VHPELEYAivkvndeKYIIASELFETVAKTLEwenaevvKTVKG 288
Cdd:COG0495 234 FPVEGSDEKIT------VFTTRPDTL---FGATfmvLAPEHPLV-------KELATPEQNAAVAAFIE-------EAKKK 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 289 SELEYTV-------------AKHPFyDRDSL-VMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGL---EVLCPVD-DK 350
Cdd:COG0495 291 SEIERTSetkektgvftglyAINPL-TGEKIpIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLpikQVIAPEDgDD 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 351 GVLTEEA---PG-------FEGLFYDKANKPITEKLEEVGallkltfithsyphdwrtkkpiIFRATAQWfasieafrke 420
Cdd:COG0495 370 PDILEEAytgDGvlinsgeFDGLDSEEAKEAIIEWLEEKG----------------------LGKRKVNY---------- 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 421 lleavaetkwvpawgetRLHnmvrdrgDWCISRQRAWGVPIPVFYAENGDPIITDEtinhvadlfrehgsnvwfereaKD 500
Cdd:COG0495 418 -----------------RLR-------DWLISRQRYWGEPIPIIHCEDCGVVPVPE----------------------DQ 451
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 501 L---LPEG--FT-HPGSP---------------NGEFRKETDIMDVWFDS----------GSSHQAVleERDDLQR--PA 547
Cdd:COG0495 452 LpveLPEDvdFDpTGGSPlarapewvnvtcpkcGGPARRETDTMDTFVDSswyylrytdpHNDEAPF--DPEAANYwlPV 529
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 548 DLYLEGSDQ------Y-RGWfnsslsTAV-----AVTGKAPYKGVLSHGFVLD--------GEGRKMSKSIGNIVVPKKI 607
Cdd:COG0495 530 DQYIGGIEHailhllYaRFF------TKVlrdlgLVSFDEPFKRLLTQGMVLEvgkdgvviGGIEKMSKSKGNVVDPDEI 603
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 608 MDQLGGDILRLWVSSV-DYQSDVRISDdilKQVAEVYRKIRNTFRFLLGNLDDFKpsentVAVAELREVDRYMLVKLNDL 686
Cdd:COG0495 604 IEKYGADTLRLFEMFAgPPERDLEWSD---SGVEGAYRFLNRVWRLVVDEAEALK-----LDVADLSEADKELRRALHKT 675
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 687 ITKVKEAYETYDF----AAVYhaihnfctidlssfylDFAKDILYIEGANHEDRRAIQtvlyDVLVALTKLVTPILPHTA 762
Cdd:COG0495 676 IKKVTEDIERLRFntaiAALM----------------ELVNALYKAKDSGEADRAVLR----EALETLVLLLAPFAPHIA 735
|
890 900 910
....*....|....*....|....*....|...
gi 81583658 763 DEVWPYIPGvtEESVQLTDMPEAvqldDAEALK 795
Cdd:COG0495 736 EELWERLGH--EGSVADAPWPEA----DEAALV 762
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
63-867 |
4.77e-35 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 144.24 E-value: 4.77e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 63 IHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIeQALTNKGVKRKEMTVAEFRKLC----------------AE 126
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPI-LGIAERIARGDPETIELYKSLYgipeeelekfkdpeyiVE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 127 YAYEQVErqrEQFKRLGVRADWDNPYITLEPAYEA----QqikvFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIeyQD 202
Cdd:PRK12300 80 YFSEEAK---EDMKRIGYSIDWRREFTTTDPEYSKfiewQ----FRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDL--LD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 203 KKSASI--YVAfsVKdgknvLEGDEKYIIWTTT--PWTLPANLGISVHPELEYAIVKVNDEKYIIASELFETVAKTLEwe 278
Cdd:PRK12300 151 GEEPEIveYTL--IK-----FEESEDLILPAATlrPETIFGVTNLWVNPDATYVKAEVDGEKWIVSKEAAEKLSFQDR-- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 279 NAEVVKTVKGSELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGK-----KYGLEVLCPV------ 347
Cdd:PRK12300 222 DVEIIEEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYVALRdlkknKELLDVIEPIplieve 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 348 -------------------DD----------------KGVLTEEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHsy 392
Cdd:PRK12300 302 gygefpakevveklgiksqEDpeleeatkevyraefhKGVLKENTGEYAGKPVREAREKITKDLIEKGIADIMYEFSN-- 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 393 phdwrtkKPIIFRATA---------QWFA--SIEAFRKELLEAVAETKWVPawGETR--LHNMVRDRGDWCISRQRAWGV 459
Cdd:PRK12300 380 -------RPVYCRCGTecvvkvvkdQWFIdySDPEWKELAHKALDNMEIIP--EEYRkeFENTIDWLKDRACARRRGLGT 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 460 PIPVfyaengDP--II---TDETINH----VADLFREHGSNvwfereAKDLLPEGFTHPgspngeFRKETDIMDVWFDSG 530
Cdd:PRK12300 451 RLPW------DEewIIeslSDSTIYMayytIAHKIREYGIK------PEQLTPEFFDYV------FLGKGDPEEVSKKTG 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 531 SSHQAVLEERDDLQ--RPADLYLEGSDQ-------YrgWFNSslstaVAVTGKAPY-KGVLSHGFVLDgEGRKMSKSIGN 600
Cdd:PRK12300 513 IPKEILEEMREEFLywYPVDWRHSGKDLipnhltfF--IFNH-----VAIFPEEKWpRGIVVNGFVLL-EGKKMSKSKGN 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 601 IVVPKKIMDQLGGDILRLWV-SSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDDfkpsentvavAELREVDRYM 679
Cdd:PRK12300 585 VIPLRKAIEEYGADVVRLYLtSSAELLQDADWREKEVESVRRQLERFYELAKELIEIGGE----------EELRFIDKWL 654
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 680 LVKLNDLITKVKEAYETYDFAAVYhaihnfctidLSSFYlDFAKDI-LYIEGANHEDRRaiqtVLYDVLVALTKLVTPIL 758
Cdd:PRK12300 655 LSRLNRIIKETTEAMESFQTRDAV----------QEAFY-ELLNDLrWYLRRVGEANNK----VLREVLEIWIRLLAPFT 719
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 759 PHTADEVWPYIPGvtEESVQLTDMPEAVQLddaealktKWDAFMTLRDDVLKAL-EVARNEKVIGKSLNASITLYPTAEM 837
Cdd:PRK12300 720 PHLAEELWHKLGG--EGFVSLEKWPEPDES--------KIDEEAELAEEYVKRLiEDIREILKVAKIKPKKVYIYVAPDW 789
|
890 900 910
....*....|....*....|....*....|....*
gi 81583658 838 K---AMLESINEDLKQLF--IVSEYKLGGMMEEAP 867
Cdd:PRK12300 790 KyevLEIAAENGDVKEAIkeLMKDEELRKHGKEVA 824
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
676-831 |
5.04e-34 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 127.13 E-value: 5.04e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 676 DRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYiegaNHEDRRAIQTVLYDVLVALTKLVT 755
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLY----GEEPDSRAQTTLYEVLETLLRLLA 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81583658 756 PILPHTADEVWpyipgvTEESVQLTDMPEAVQLDDAEalktkWDAFMTLRDDVLKALEVARNEKVIGKSLNASITL 831
Cdd:pfam08264 77 PFMPFITEELW------QKESIHLAPWPEDAELEEAE-----LEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
637-785 |
1.13e-26 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 107.64 E-value: 1.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 637 KQVAEVYRK----IRNTFRFLLG--NLDDFKPSENTVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFC 710
Cdd:cd07961 4 KGVREVVRKvllpLWNAYRFFVTyaNLDGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81583658 711 tIDLSSFYLDFAKDILYIEGANHEDRRAIQTvLYDVLVALTKLVTPILPHTADEVW----PYIPGvTEESVQLTDMPEA 785
Cdd:cd07961 84 -DELTNWYIRRNRKRFWGEEGDDDKLAAYAT-LYEVLLTLSRLMAPFTPFITEEIYqnlrRELGD-APESVHLLDWPEV 159
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
638-766 |
9.40e-24 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 97.63 E-value: 9.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 638 QVAEVYR----KIRNTFRFLLGNLDDFKPSENTVAVAELreVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTID 713
Cdd:cd07962 4 KRVEGGRnfcnKLWNAARFVLMNLEDDDEPEEDPESLSL--ADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWND 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 81583658 714 LSSFYLDFAKDILYIEGAnhEDRRAIQTVLYDVLVALTKLVTPILPHTADEVW 766
Cdd:cd07962 82 FCDWYLELVKPRLYGEDE--EEKKAARATLYYVLETILRLLHPFMPFITEELW 132
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
57-766 |
4.79e-21 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 98.26 E-value: 4.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVkrkemTVAEFrklCAEYAyeqvERQR 136
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGI-----TPQEL---VDRIH----AEFK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 137 EQFKRLGVraDWDNpYI-TLEPAYEAQQIKVFGDMAKKGYIYKGqkpvywsptsesalaeaEIEyqdkksasiyVAFSVK 215
Cdd:COG0143 78 ELFEKLGI--SFDN-FIrTTSPEHKELVQEIFQRLYDNGDIYKG-----------------EYE----------GWYCPE 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 216 DGKnvlegdekyiiwtttpwtlpanlgisvhpeleyaivkvndekyiiaselfetvaktlewenaevvktvkgseleytv 295
Cdd:COG0143 128 CER----------------------------------------------------------------------------- 130
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 296 akhpFYDrdslvmlgdhvttdagtgcvhtapghgeDDFIVGKkyglevlCPVDDkgvlTEEAPGFEglfydkankpitek 375
Cdd:COG0143 131 ----FLP----------------------------DRYVEGT-------CPKCG----AEDAYGDQ-------------- 153
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 376 LEEVGALLKLTFITHsyPHDWRTKKPIIFRATAQWFASIEAFRKELLEAVAEtkwVPAWGETRLHNMVR--DRG--DWCI 451
Cdd:COG0143 154 CENCGATLEPTELIN--PRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEE---NPDIQPEVRNEVLSwlKEGlqDLSI 228
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 452 SRQRAWGVPIPvfyaenGDPiitdetiNHVadlfrehgsnvwfereakdllpegfthpgspngefrketdiMDVWFD--- 528
Cdd:COG0143 229 SRDFDWGIPVP------GDP-------GKV-----------------------------------------FYVWFDali 254
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 529 ---SgsshqAVLEERDDLQRPADlylegsdqYRGWFNSSLSTAVAVTGK-------------------APYKGVLSHGFV 586
Cdd:COG0143 255 gyiS-----ATKGYADDRGLPED--------FEKYWPAPDTELVHFIGKdiirfhaiiwpamlmaaglPLPKKVFAHGFL 321
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 587 LDgEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSS-VDYQSDVRISDDILKQV--AE--------VYRKIRNTFRFLLG 655
Cdd:COG0143 322 TV-EGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLReVPFGQDGDFSWEDFVARvnSDlandlgnlASRTLSMIHKYFDG 400
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 656 NLDdfkpsentvAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFctIDLSSFYLD------FAKDilyie 729
Cdd:COG0143 401 KVP---------EPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMAL--ARAANKYIDetapwkLAKD----- 464
|
730 740 750 760
....*....|....*....|....*....|....*....|
gi 81583658 730 ganhEDRRAIQTVLY---DVLVALTKLVTPILPHTADEVW 766
Cdd:COG0143 465 ----EDPERLATVLYtllEALRILAILLKPFLPETAEKIL 500
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
57-185 |
1.49e-17 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 84.61 E-value: 1.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKEMTvaefrklcaeyaYEQVERQR 136
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWT------------EYNIKKMK 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 81583658 137 EQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYW 185
Cdd:cd00812 77 EQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
57-794 |
1.71e-17 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 86.66 E-value: 1.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKEmtvaefrkLCAEYayeqVERQR 136
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQEGLTPKE--------LVDKY----HEEFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 137 EQFKRLGVraDWDNPYITLEPAYEAQQIKVFGDMAKKGYIYkgqkpvywsptsesalaEAEIEYqdkksasiyvAFSVKD 216
Cdd:TIGR00398 76 DDWKWLNI--SFDRFIRTTDEEHKEIVQKIFQKLKENGYIY-----------------EKEIKQ----------LYCPEC 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 217 GKNvlegdekyiiwtttpwtlpanlgisvhpeleYAIVKVNDEKYIIASElfetvaktlewenaevvktvkgseleytva 296
Cdd:TIGR00398 127 EMF-------------------------------LPDRYVEGTCPKCGSE------------------------------ 145
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 297 khpfydrdslVMLGDHvttdaGTGC-VHTAPGhgedDFIvgkkyglEVLCPVDD-KGVLTEEAPGFEGLfyDKANKPITE 374
Cdd:TIGR00398 146 ----------DARGDH-----CEVCgRHLEPT----ELI-------NPRCKICGaKPELRDSEHYFFRL--SAFEKELEE 197
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 375 KleevgallkltfithsyphdwrTKKPIIFRATAqwfasieafrKELLEAVAEtkwvpaWGETRLHnmvrdrgDWCISRQ 454
Cdd:TIGR00398 198 W----------------------IRKNPESGSPA----------SNVKNKAQN------WLKGGLK-------DLAITRD 232
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 455 RA-WGVPIPvfyaenGDPiitdetiNHVAdlfrehgsNVWFEReakdllPEGFThpgSPNGEFRKETDIMDVWFDSGSSH 533
Cdd:TIGR00398 233 LVyWGIPVP------NDP-------NKVV--------YVWFDA------LIGYI---SSLGILSGDTEDWKKWWNNDEDA 282
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 534 QAVLEERDDLQR------PAdlYLEGSdqyrGWfnsslstavavtgKAPyKGVLSHGFVLDgEGRKMSKSIGNIVVPKKI 607
Cdd:TIGR00398 283 ELIHFIGKDIVRfhtiywPA--MLMGL----GL-------------PLP-TQVFSHGYLTV-EGGKMSKSLGNVVDPSDL 341
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 608 MDQLGGDILRLW-VSSVDYQSDVRISDDILKQV--AE--------VYRKIRNTFRFLLGNLDDFKpsentvavaELREVD 676
Cdd:TIGR00398 342 LARFGADILRYYlLKERPLGKDGDFSWEDFVERvnADlanklgnlLNRTLGFIKKYFNGVLPSED---------ITDEED 412
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 677 RYMLVKLNDLITKVKEAYETYDF-AAVYHAIHnfcTIDLSSFYLDFAKDilyIEGANHEDR-RAIQTVLYDVLVALTKLV 754
Cdd:TIGR00398 413 KKLLKLINEALEQIDEAIESFEFrKALREIMK---LADRGNKYIDENKP---WELFKQSPRlKELLAVCSMLIRVLSILL 486
|
730 740 750 760
....*....|....*....|....*....|....*....|
gi 81583658 755 TPILPHTADEVWPYIpGVTEESVQLTDMPEAVQLDDAEAL 794
Cdd:TIGR00398 487 YPIMPKLSEKILKFL-NFELEWDFKLKLLEGHKLNKAEPL 525
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
57-199 |
5.75e-17 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 83.88 E-value: 5.75e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVkrkemTVAEfrkLCAEYayeqVERQR 136
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGI-----TPEE---LVDRY----HEIHR 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81583658 137 EQFKRLGVraDWDNPYITLEPA-YEAQQiKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIE 199
Cdd:pfam09334 76 EDFKKFNI--SFDDYGRTTSERhHELVQ-EFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE 136
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
633-758 |
4.82e-16 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 74.85 E-value: 4.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 633 DDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENTvavAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTI 712
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFFRKALGGTQPKWDN---ELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNE 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 81583658 713 DlsSFYLDFAKDILYIEganhEDRRAIQTVLYDVLVALTKLVTPIL 758
Cdd:cd07375 78 L--NWYLDELKPALQTE----ELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
57-195 |
4.17e-15 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 77.19 E-value: 4.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKEmtvaefrkLCAEYAyeqvERQR 136
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQE--------LCDKYH----EIFK 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 81583658 137 EQFKRLGVraDWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAE 195
Cdd:cd00814 77 DLFKWLNI--SFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLPE 133
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
448-766 |
3.18e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 73.38 E-value: 3.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 448 DWCISRQRA-WGVPIPvfyaenGDPiitdetiNHVadlfrehgsnvwfereakdllpegfthpgspngefrketdiMDVW 526
Cdd:PRK11893 200 DLSISRTNFdWGIPVP------GDP-------KHV-----------------------------------------IYVW 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 527 FDSGSSHQAVLEERDDLQR---------PADLYLEGSDQYRgwFNSSLSTAV--AVTGKAPyKGVLSHGFVLDgEGRKMS 595
Cdd:PRK11893 226 FDALTNYLTALGYPDDEELlaelfnkywPADVHLIGKDILR--FHAVYWPAFlmAAGLPLP-KRVFAHGFLTL-DGEKMS 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 596 KSIGNIVVPKKIMDQLGGDILRLWVSS-VDYQSDVRISDDILKQV--AEVYRKIRN----TFRFLLGNLDDFKPSentva 668
Cdd:PRK11893 302 KSLGNVIDPFDLVDEYGVDAVRYFLLReIPFGQDGDFSREAFINRinADLANDLGNlaqrTLSMIAKNFDGKVPE----- 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 669 VAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIhnfctIDLSSF---YLDfakdilyiEGA----NHEDRRAIQT 741
Cdd:PRK11893 377 PGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAI-----LALVRAankYID--------EQApwslAKTDPERLAT 443
|
330 340 350
....*....|....*....|....*....|
gi 81583658 742 VLYDVL-----VALtkLVTPILPHTADEVW 766
Cdd:PRK11893 444 VLYTLLevlrgIAV--LLQPVMPELAAKIL 471
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
57-178 |
1.79e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 61.32 E-value: 1.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEqaltnkgVKRKEMTVAEfRKLCAEYAyeqvERQR 136
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIM-------LKAEKEGITP-EELIARYH----AEHK 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 81583658 137 EQFKRLGVraDWDNPYITLEPA-YE-AQQIkvFGDMAKKGYIYK 178
Cdd:PRK00133 79 RDFAGFGI--SFDNYGSTHSEEnRElAQEI--YLKLKENGYIYE 118
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
409-629 |
2.11e-09 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 59.95 E-value: 2.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 409 QWFASI--EAFRKELLEAVAETKWVPAwgETRlhNMVRDRGDwcISRQRAWGVPIPVfyaengdpiitdetinhvadlfr 486
Cdd:cd00812 131 QWFLKYseTEWKEKLLKDLEKLDGWPE--EVR--AMQENWIG--CSRQRYWGTPIPW----------------------- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 487 ehgsnvwfereakdllpegfthpgspngefrkeTDIMDVWFDSG----------SSHQAVLEERDDLQR------PADLY 550
Cdd:cd00812 182 ---------------------------------TDTMESLSDSTwyyarytdahNLEQPYEGDLEFDREefeywyPVDIY 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 551 LEGSDQ-------YRgwFNSSLSTAVAVTGKAPYKGVLSHGFVLdGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWV-SS 622
Cdd:cd00812 229 IGGKEHapnhllySR--FNHKALFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIKKYGADAARLYIlFA 305
|
....*..
gi 81583658 623 VDYQSDV 629
Cdd:cd00812 306 APPDADF 312
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
403-617 |
2.43e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.85 E-value: 2.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 403 IFRATAQWFASIEAFRKELLEAVAETKwVPAWGETRlHNMVRDR-----GDWCISRQRA-WGVPIP-----VFYaengdp 471
Cdd:cd00814 133 EWREEEHYFFRLSKFQDRLLEWLEKNP-DFIWPENA-RNEVLSWlkeglKDLSITRDLFdWGIPVPldpgkVIY------ 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 472 iitdetinhvadlfrehgsnVWFereakDLLPEGFTHPGSPNGEFRKETDIMDVWfdsgsshqavleerddlqrPADLYL 551
Cdd:cd00814 205 --------------------VWF-----DALIGYISATGYYNEEWGNSWWWKDGW-------------------PELVHF 240
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81583658 552 EGSD------QYrgwFNSSLSTAvavtGKAPYKGVLSHGFVLDgEGRKMSKSIGNIVVPKKIMDQLGGDILR 617
Cdd:cd00814 241 IGKDiirfhaIY---WPAMLLGA----GLPLPTRIVAHGYLTV-EGKKMSKSRGNVVDPDDLLERYGADALR 304
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
58-179 |
3.77e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 60.58 E-value: 3.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 58 YANGDIHMGHALNKVLKDFIVRYKSMTGFCAPYVPGWDTHGLPIEQALTNKGVKRKemtvaefrklcaEYAYEQVERQRE 137
Cdd:PRK12267 14 YPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQ------------EYVDEISAGFKE 81
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 81583658 138 QFKRLGVRADwdnPYI-TLEPAYEAQQIKVFGDMAKKGYIYKG 179
Cdd:PRK12267 82 LWKKLDISYD---KFIrTTDERHKKVVQKIFEKLYEQGDIYKG 121
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
583-674 |
1.30e-08 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 58.19 E-value: 1.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 583 HGFV-LDGEgrKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDdfK 661
Cdd:COG0215 256 NGFLtVNGE--KMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEALG--A 331
|
90
....*....|...
gi 81583658 662 PSENTVAVAELRE 674
Cdd:COG0215 332 ADSSAEEIEELRE 344
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
663-766 |
1.09e-07 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 51.05 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 663 SENTVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIhnfctidlssFYlDFAKDI-LYIEGANHEDRRAiqt 741
Cdd:cd07959 24 IETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEG----------LY-ELQNDLdWYRERGGAGMNKD--- 89
|
90 100
....*....|....*....|....*
gi 81583658 742 VLYDVLVALTKLVTPILPHTADEVW 766
Cdd:cd07959 90 LLRRFIEVWTRLLAPFAPHLAEEIW 114
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
401-815 |
3.53e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 54.00 E-value: 3.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 401 PIIFRATAQWFASIEAFRKELLEavaetkwvpaWGETRLH------NMVR---DRG--DWCISRQRAW-GVPIP-----V 463
Cdd:PRK00133 178 TPVLKESEHFFFKLPRFEEFLKE----------WITRSGElqpnvaNKMKewlEEGlqDWDISRDAPYfGFEIPgapgkV 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 464 FYaengdpiitdetinhvadlfrehgsnVWFEreA--------KDLLPEgfthpgspngefRKETDIMDVWFDSGSS--- 532
Cdd:PRK00133 248 FY--------------------------VWLD--ApigyisstKNLCDK------------RGGLDWDEYWKKDSDTely 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 533 ---------HQAVLeerddlqRPAdlYLEGSDqYRgwfnssLSTAVAVtgkapykgvlsHGFvLDGEGRKMSKSIGNIVV 603
Cdd:PRK00133 288 hfigkdiiyFHTLF-------WPA--MLEGAG-YR------LPTNVFA-----------HGF-LTVEGAKMSKSRGTFIW 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 604 PKKIMDQLGGDILR--------LWVSSVDYQSDV---RISDDIL-KQVAEVYRKIRNTFRFLLGNLDDfkpsentvavae 671
Cdd:PRK00133 340 ARTYLDHLDPDYLRyylaaklpETIDDLDFNWEDfqqRVNSELVgKVVNFASRTAGFINKRFDGKLPD------------ 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 672 lREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIhnfctIDLSSF---YLD------FAKdilyieganhEDRRAIQTV 742
Cdd:PRK00133 408 -ALADPELLEEFEAAAEKIAEAYEAREFRKALREI-----MALADFankYVDdnepwkLAK----------QDGERLQAV 471
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81583658 743 LYDVLV---ALTKLVTPILPHTADEVWPYIpGVTEESVQLTDMPEAV-QLDDAEALKTKWDafmtlrDDVLKALEVA 815
Cdd:PRK00133 472 CSVGLNlfrALAIYLKPVLPELAERAEAFL-NLEELTWDDAQQPLAGhPINKFKILFTRIE------DKQIEALIEA 541
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
576-766 |
1.16e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 52.50 E-value: 1.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 576 PYKGVLSHGFVLdGEGRKMSKSIGNIVVPKKIMDQLGGDILRLW-VSSVDYQSDVRISDDILKQvaevyrkirntfRF-- 652
Cdd:PRK12267 283 LPKKVFAHGWWL-MKDGKMSKSKGNVVDPEELVDRYGLDALRYYlLREVPFGSDGDFSPEALVE------------RIns 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 653 -L---LGNLDD------FKPSENTV-AVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFctIDLSSFYLD- 720
Cdd:PRK12267 350 dLandLGNLLNrtvamiNKYFDGEIpAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKL--ISRANKYIDe 427
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 81583658 721 -----FAKDilyieganHEDRRAIQTVLYDVLVALTK---LVTPILPHTADEVW 766
Cdd:PRK12267 428 tapwvLAKD--------EGKKERLATVMYHLAESLRKvavLLSPFMPETSKKIF 473
|
|
| zf-FPG_IleRS |
pfam06827 |
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of ... |
885-912 |
1.28e-06 |
|
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23.
Pssm-ID: 429140 [Multi-domain] Cd Length: 28 Bit Score: 45.27 E-value: 1.28e-06
10 20
....*....|....*....|....*...
gi 81583658 885 GETCERCWVVSETIGKDAEHETLCERCA 912
Cdd:pfam06827 1 GEKCPRCWTYIEKVGVGGRSTYFCPRCQ 28
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
485-775 |
2.48e-06 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 51.25 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 485 FREHGSNVWFEREAKDL-LPEGFTHPGSPNGEFRKETdiMDVWFDSGSSHQAVLEERDDLQR---------PADLYLEGS 554
Cdd:PLN02224 252 YRLNEVQSWIKSGLRDFsISRALVDWGIPVPDDDKQT--IYVWFDALLGYISALTEDNKQQNletavsfgwPASLHLIGK 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 555 DQYRgwFNSSLSTAVAVT-GKAPYKGVLSHGFvLDGEGRKMSKSIGNIVVPKKIMDQLGGDILR-LWVSSVDYQSDVRIS 632
Cdd:PLN02224 330 DILR--FHAVYWPAMLMSaGLELPKMVFGHGF-LTKDGMKMGKSLGNTLEPFELVQKFGPDAVRyFFLREVEFGNDGDYS 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 633 DDILKQV--AEVYRKIRNTFRFLLGNLDdfKPSENTVAVAELREVDRYMLV-KLNDLITKVKEAYETYDFAAVYHAIHNF 709
Cdd:PLN02224 407 EDRFIKIvnAHLANTIGNLLNRTLGLLK--KNCESTLVEDSTVAAEGVPLKdTVEKLVEKAQTNYENLSLSSACEAVLEI 484
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81583658 710 CtiDLSSFYLD-FAKDILYIEGA-NHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIpGVTEE 775
Cdd:PLN02224 485 G--NAGNTYMDqRAPWFLFKQGGvSAEEAAKDLVIILEVMRVIAVALSPIAPCLSLRIYSQL-GYSED 549
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
204-377 |
4.85e-06 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 47.93 E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 204 KSASIYVAFSVKDGknvlegDEKYIIWTTTPWTLpanLGISvhpeleyaivkvndekYI-IASE--LFETVAKTLEwENA 280
Cdd:pfam13603 6 RSEGAEITFPVEGT------DEKIEVFTTRPDTL---MGVT----------------FVaLAPEhpLVEKLAEKNP-EVA 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 281 EVVKTVKG-SELEYTVAK-------------HPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFIVGKKYGLE---V 343
Cdd:pfam13603 60 AFIEECKNtSEIERTSETkekegvftglyaiHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPikpV 139
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 81583658 344 LCPVD-------------DKGVLTEEAPgFEGLFYDKANKPITEKLE 377
Cdd:pfam13603 140 IQPEDgdldldimteaytEEGILVNSGE-FDGLDSEEAKEAIIKKLE 185
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
654-766 |
2.92e-05 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 44.40 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 654 LGNL-----------DDFKPSENTvavaELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIhnfctIDLSSF---YL 719
Cdd:cd07957 9 LGNLvnrtlnmaskyFGGVVPEFG----GLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEI-----MELARAankYI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 81583658 720 DFAKD-ILyiegANHEDRRAIQTVLYDVL---VALTKLVTPILPHTADEVW 766
Cdd:cd07957 80 DETAPwKL----AKEEDPERLATVLYVLLellRILAILLSPFMPETAEKIL 126
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
581-701 |
3.22e-03 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 41.24 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81583658 581 LSHGFV-LDGEgrKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRIS----DDILKQVAEVYRKIRNTfrfllg 655
Cdd:PRK14535 497 LHNGFIrVDGE--KMSKSLGNFFTIREVLKQYDPEVVRFFILRAHYRSPLNYSdahlDDAKGALTRLYTTLKNT------ 568
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 81583658 656 NLDDFKPSENtvavaeLREVDRYMLVKLNDLITKVKEAYETYDFAA 701
Cdd:PRK14535 569 PAAEFMLSEN------VNDYTRRFYAAMNDDFGTVEAVAVLFELAG 608
|
|
| |
