|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
773-882 |
1.28e-37 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
:
Pssm-ID: 465881 Cd Length: 110 Bit Score: 136.46 E-value: 1.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 773 VLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSD 852
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 122065990 853 ILHSLFSTYKEKILPWFEQLLPLIVNLICS 882
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
284-365 |
1.48e-26 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
:
Pssm-ID: 408579 Cd Length: 90 Bit Score: 104.08 E-value: 1.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 284 RQLALEVIVTLSETATPMLKKHTNIIAQAVPHILAMMVDLQDDDDWVNADEMEEDDFDSNAVAAESALDRLACGLGGKVV 363
Cdd:pfam18808 9 RQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLACRLGGKAL 88
|
..
gi 122065990 364 LP 365
Cdd:pfam18808 89 LP 90
|
|
| KAP95 super family |
cl27231 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
16-640 |
3.29e-11 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
The actual alignment was detected with superfamily member COG5215:
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 67.66 E-value: 3.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 16 KQEFYQLLKNLI-NPSCMVRRQAEEVYENipgLCKTTF------LLDAVRNRRAGYEVRQMAAALLRRLLSS-------G 81
Cdd:COG5215 3 KSEFRCLGKNHVlSPDPNARLRAEAQLLE---LQSGDFeqfislLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 82 FEEVYPNLPPEVQRDVKIELILAVKLETH--ASMRKKLC--------------DIFAVLARNLIDESGTNHWPEGLKFL- 144
Cdd:COG5215 80 CSQRWLGMRHESKEQVKGMALRALKSPEPrfCTMAAQLLaaiarmelpnslwpGLMEEMVRNVGDEQPVSGKCESLGICg 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 145 --------IDSIHSKNVVLWEVALhvfwhFPGIFGNQDRHDLDIIKRLLDQCIQDQEhpairtlsaraaatfVLANENNI 216
Cdd:COG5215 160 yhceseapEDLIQMSNVILFAIVM-----GALKNETTSAVRLAALKALMDSLMFVQG---------------NFCYEEER 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 217 ALFkdfadllpgiLQAVNDSCYQDDDSVLES----LVEIADTVPKYLGPYLEDTL-QLSLKLcgdsrLSNLQRQLALEVI 291
Cdd:COG5215 220 NYF----------MQVVCEATQGNDEELQHAafgcLNKIMMLYYKFMQSYMENALaALTGRF-----MKSQNDEVAIQAV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 292 --------------VTLSETATPMLKKHT---NIIAQAVPHILAMMVdlqddddwvNADEMEEDDFDSNAVAAESALDRL 354
Cdd:COG5215 285 efwsticeeeidgeMEDKYLPEVPAQNHGfarAAVADVLPELLSLLE---------KQGEDYYGDDWNPSMAASSCLQLF 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 355 ACGLGGKVVLPMTkEHIMQMLQSPDWKCRHAGLMALSAIGEG-CHQQMEPILDETVNSVLLFLQDPHPRVRAAACTTLGQ 433
Cdd:COG5215 356 AQLKGDKIMRPVL-GFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGA 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 434 MATDFAPSFQKKFH-EIVITALLRTMenQGNQRVQSHAASALVIFIEDCPK------SLLILYLENMVKSLhsilvIKLQ 506
Cdd:COG5215 435 IADHVAMIISPCGHlVLEVSASLIGL--MDCPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNAL-----VKGT 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 507 ELIRNGTKL---ALEQLVTTIASVADAIEESFIPYYDIFMPSLKHVVE-----LAVQKELKL--LRGKTIECISHVgLAV 576
Cdd:COG5215 508 ELALNESNLrvsLFSALGTLILICPDAVSDILAGFYDYTSKKLDECISvlgqiLATEDQLLVeeLQSNYIGVLEAI-IRT 586
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 122065990 577 GKEKFMQDASNVMQLLLKTqsdlnnMEDDDPQTSY--MVSAWARMCKILGKDFEQYLPLVIEPLIK 640
Cdd:COG5215 587 RRRDIEDVEDQLMELFIRI------LESTKPTTAFgdVYTAISALSTSLEERFEQYASKFIPYLTR 646
|
|
| Importin_rep_5 super family |
cl40106 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1013-1060 |
5.57e-06 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
The actual alignment was detected with superfamily member pfam18816:
Pssm-ID: 465877 Cd Length: 52 Bit Score: 44.39 E-value: 5.57e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 122065990 1013 DKEEAIQTLNFLCDLIESNHPVVIgpnnSNLPKIISIIAEGKINETIS 1060
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVT----SQIPKVVDSVVQALEHKSLS 44
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
773-882 |
1.28e-37 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
Pssm-ID: 465881 Cd Length: 110 Bit Score: 136.46 E-value: 1.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 773 VLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSD 852
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 122065990 853 ILHSLFSTYKEKILPWFEQLLPLIVNLICS 882
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
284-365 |
1.48e-26 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
Pssm-ID: 408579 Cd Length: 90 Bit Score: 104.08 E-value: 1.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 284 RQLALEVIVTLSETATPMLKKHTNIIAQAVPHILAMMVDLQDDDDWVNADEMEEDDFDSNAVAAESALDRLACGLGGKVV 363
Cdd:pfam18808 9 RQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLACRLGGKAL 88
|
..
gi 122065990 364 LP 365
Cdd:pfam18808 89 LP 90
|
|
| KAP95 |
COG5215 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
16-640 |
3.29e-11 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 67.66 E-value: 3.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 16 KQEFYQLLKNLI-NPSCMVRRQAEEVYENipgLCKTTF------LLDAVRNRRAGYEVRQMAAALLRRLLSS-------G 81
Cdd:COG5215 3 KSEFRCLGKNHVlSPDPNARLRAEAQLLE---LQSGDFeqfislLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 82 FEEVYPNLPPEVQRDVKIELILAVKLETH--ASMRKKLC--------------DIFAVLARNLIDESGTNHWPEGLKFL- 144
Cdd:COG5215 80 CSQRWLGMRHESKEQVKGMALRALKSPEPrfCTMAAQLLaaiarmelpnslwpGLMEEMVRNVGDEQPVSGKCESLGICg 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 145 --------IDSIHSKNVVLWEVALhvfwhFPGIFGNQDRHDLDIIKRLLDQCIQDQEhpairtlsaraaatfVLANENNI 216
Cdd:COG5215 160 yhceseapEDLIQMSNVILFAIVM-----GALKNETTSAVRLAALKALMDSLMFVQG---------------NFCYEEER 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 217 ALFkdfadllpgiLQAVNDSCYQDDDSVLES----LVEIADTVPKYLGPYLEDTL-QLSLKLcgdsrLSNLQRQLALEVI 291
Cdd:COG5215 220 NYF----------MQVVCEATQGNDEELQHAafgcLNKIMMLYYKFMQSYMENALaALTGRF-----MKSQNDEVAIQAV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 292 --------------VTLSETATPMLKKHT---NIIAQAVPHILAMMVdlqddddwvNADEMEEDDFDSNAVAAESALDRL 354
Cdd:COG5215 285 efwsticeeeidgeMEDKYLPEVPAQNHGfarAAVADVLPELLSLLE---------KQGEDYYGDDWNPSMAASSCLQLF 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 355 ACGLGGKVVLPMTkEHIMQMLQSPDWKCRHAGLMALSAIGEG-CHQQMEPILDETVNSVLLFLQDPHPRVRAAACTTLGQ 433
Cdd:COG5215 356 AQLKGDKIMRPVL-GFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGA 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 434 MATDFAPSFQKKFH-EIVITALLRTMenQGNQRVQSHAASALVIFIEDCPK------SLLILYLENMVKSLhsilvIKLQ 506
Cdd:COG5215 435 IADHVAMIISPCGHlVLEVSASLIGL--MDCPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNAL-----VKGT 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 507 ELIRNGTKL---ALEQLVTTIASVADAIEESFIPYYDIFMPSLKHVVE-----LAVQKELKL--LRGKTIECISHVgLAV 576
Cdd:COG5215 508 ELALNESNLrvsLFSALGTLILICPDAVSDILAGFYDYTSKKLDECISvlgqiLATEDQLLVeeLQSNYIGVLEAI-IRT 586
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 122065990 577 GKEKFMQDASNVMQLLLKTqsdlnnMEDDDPQTSY--MVSAWARMCKILGKDFEQYLPLVIEPLIK 640
Cdd:COG5215 587 RRRDIEDVEDQLMELFIRI------LESTKPTTAFgdVYTAISALSTSLEERFEQYASKFIPYLTR 646
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
380-434 |
9.29e-09 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 52.37 E-value: 9.29e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 122065990 380 WKCRHAGLMALSAIGEGCHQQMEPILDETVNSVLLFLQDPHPRVRAAACTTLGQM 434
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
|
|
| Importin_rep_5 |
pfam18816 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1013-1060 |
5.57e-06 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
Pssm-ID: 465877 Cd Length: 52 Bit Score: 44.39 E-value: 5.57e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 122065990 1013 DKEEAIQTLNFLCDLIESNHPVVIgpnnSNLPKIISIIAEGKINETIS 1060
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVT----SQIPKVVDSVVQALEHKSLS 44
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
773-882 |
1.28e-37 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
Pssm-ID: 465881 Cd Length: 110 Bit Score: 136.46 E-value: 1.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 773 VLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSD 852
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 122065990 853 ILHSLFSTYKEKILPWFEQLLPLIVNLICS 882
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
284-365 |
1.48e-26 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
Pssm-ID: 408579 Cd Length: 90 Bit Score: 104.08 E-value: 1.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 284 RQLALEVIVTLSETATPMLKKHTNIIAQAVPHILAMMVDLQDDDDWVNADEMEEDDFDSNAVAAESALDRLACGLGGKVV 363
Cdd:pfam18808 9 RQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLACRLGGKAL 88
|
..
gi 122065990 364 LP 365
Cdd:pfam18808 89 LP 90
|
|
| KAP95 |
COG5215 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
16-640 |
3.29e-11 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 67.66 E-value: 3.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 16 KQEFYQLLKNLI-NPSCMVRRQAEEVYENipgLCKTTF------LLDAVRNRRAGYEVRQMAAALLRRLLSS-------G 81
Cdd:COG5215 3 KSEFRCLGKNHVlSPDPNARLRAEAQLLE---LQSGDFeqfislLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 82 FEEVYPNLPPEVQRDVKIELILAVKLETH--ASMRKKLC--------------DIFAVLARNLIDESGTNHWPEGLKFL- 144
Cdd:COG5215 80 CSQRWLGMRHESKEQVKGMALRALKSPEPrfCTMAAQLLaaiarmelpnslwpGLMEEMVRNVGDEQPVSGKCESLGICg 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 145 --------IDSIHSKNVVLWEVALhvfwhFPGIFGNQDRHDLDIIKRLLDQCIQDQEhpairtlsaraaatfVLANENNI 216
Cdd:COG5215 160 yhceseapEDLIQMSNVILFAIVM-----GALKNETTSAVRLAALKALMDSLMFVQG---------------NFCYEEER 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 217 ALFkdfadllpgiLQAVNDSCYQDDDSVLES----LVEIADTVPKYLGPYLEDTL-QLSLKLcgdsrLSNLQRQLALEVI 291
Cdd:COG5215 220 NYF----------MQVVCEATQGNDEELQHAafgcLNKIMMLYYKFMQSYMENALaALTGRF-----MKSQNDEVAIQAV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 292 --------------VTLSETATPMLKKHT---NIIAQAVPHILAMMVdlqddddwvNADEMEEDDFDSNAVAAESALDRL 354
Cdd:COG5215 285 efwsticeeeidgeMEDKYLPEVPAQNHGfarAAVADVLPELLSLLE---------KQGEDYYGDDWNPSMAASSCLQLF 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 355 ACGLGGKVVLPMTkEHIMQMLQSPDWKCRHAGLMALSAIGEG-CHQQMEPILDETVNSVLLFLQDPHPRVRAAACTTLGQ 433
Cdd:COG5215 356 AQLKGDKIMRPVL-GFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGA 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 434 MATDFAPSFQKKFH-EIVITALLRTMenQGNQRVQSHAASALVIFIEDCPK------SLLILYLENMVKSLhsilvIKLQ 506
Cdd:COG5215 435 IADHVAMIISPCGHlVLEVSASLIGL--MDCPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNAL-----VKGT 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 507 ELIRNGTKL---ALEQLVTTIASVADAIEESFIPYYDIFMPSLKHVVE-----LAVQKELKL--LRGKTIECISHVgLAV 576
Cdd:COG5215 508 ELALNESNLrvsLFSALGTLILICPDAVSDILAGFYDYTSKKLDECISvlgqiLATEDQLLVeeLQSNYIGVLEAI-IRT 586
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 122065990 577 GKEKFMQDASNVMQLLLKTqsdlnnMEDDDPQTSY--MVSAWARMCKILGKDFEQYLPLVIEPLIK 640
Cdd:COG5215 587 RRRDIEDVEDQLMELFIRI------LESTKPTTAFgdVYTAISALSTSLEERFEQYASKFIPYLTR 646
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
380-434 |
9.29e-09 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 52.37 E-value: 9.29e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 122065990 380 WKCRHAGLMALSAIGEGCHQQMEPILDETVNSVLLFLQDPHPRVRAAACTTLGQM 434
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
310-474 |
8.78e-08 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 52.32 E-value: 8.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 310 AQAVPHILAMmvdLQDDDDWVnademeeddfdsnAVAAESALdrlacglgGKVVLPMTKEHIMQMLQSPDWKCRHAGLMA 389
Cdd:COG1413 15 PAAVPALIAA---LADEDPDV-------------RAAAARAL--------GRLGDPRAVPALLEALKDPDPEVRAAAAEA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 390 LSAIGEgchqqmepilDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFApsfqkkfheivITALLRTMENQgNQRVQSH 469
Cdd:COG1413 71 LGRIGD----------PEAVPALIAALKDEDPEVRRAAAEALGRLGDPAA-----------VPALLEALKDP-DWEVRRA 128
|
....*
gi 122065990 470 AASAL 474
Cdd:COG1413 129 AARAL 133
|
|
| Importin_rep_5 |
pfam18816 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1013-1060 |
5.57e-06 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
Pssm-ID: 465877 Cd Length: 52 Bit Score: 44.39 E-value: 5.57e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 122065990 1013 DKEEAIQTLNFLCDLIESNHPVVIgpnnSNLPKIISIIAEGKINETIS 1060
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVT----SQIPKVVDSVVQALEHKSLS 44
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
373-474 |
5.67e-06 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 45.79 E-value: 5.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 373 QMLQSPDWKCRHAGLMALSAIGEgchqqmepilDETVNSVLLFLQDPHPRVRAAACTTLGQMATdfapsfqkkfhEIVIT 452
Cdd:pfam13646 7 ALLRDPDPEVRAAAIRALGRIGD----------PEAVPALLELLKDEDPAVRRAAAEALGKIGD-----------PEALP 65
|
90 100
....*....|....*....|..
gi 122065990 453 ALLRTMENQGNQRVQSHAASAL 474
Cdd:pfam13646 66 ALLELLRDDDDDVVRAAAAEAL 87
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
310-435 |
9.91e-05 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 43.46 E-value: 9.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122065990 310 AQAVPHILAMmvdLQDDDDWVNAdemeeddfdsnavAAESALdrlaCGLGGKVVLPmtkeHIMQMLQSPDWKCRHAGLMA 389
Cdd:COG1413 46 PRAVPALLEA---LKDPDPEVRA-------------AAAEAL----GRIGDPEAVP----ALIAALKDEDPEVRRAAAEA 101
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 122065990 390 LSAIGEgchqqmepilDETVNSVLLFLQDPHPRVRAAACTTLGQMA 435
Cdd:COG1413 102 LGRLGD----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
|
|
| Vac14_Fab1_bd |
pfam12755 |
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex ... |
383-431 |
5.82e-04 |
|
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.
Pssm-ID: 403838 Cd Length: 97 Bit Score: 40.27 E-value: 5.82e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 122065990 383 RHAGLMALSAIGEGCHQQMEPILDETVNSVLLFLQDPHPRVRAAACTTL 431
Cdd:pfam12755 3 RKGGLIGLAATAIALGKDIAPYLDDIIPPVLACFSDQDSRVRYYACESL 51
|
|
| |
