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Conserved domains on  [gi|152031554|sp|Q8BLS7|]
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RecName: Full=Ankyrin repeat domain-containing protein SOWAHA; AltName: Full=Ankyrin repeat domain-containing protein 43; AltName: Full=Protein sosondowah homolog A; Flags: Precursor

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
345-437 6.91e-17

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.15  E-value: 6.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 345 GFTALHWAAKNGDREMALQLVEvarrggAPVDVNARSHGGYTPLHLAALHGHEDAAVLLvVRLGAQVHVRDYSGRRAYQY 424
Cdd:COG0666  153 GNTPLHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLL-LEAGADVNAKDNDGKTALDL 225
                         90
                 ....*....|...
gi 152031554 425 LRPGSSYALRRLL 437
Cdd:COG0666  226 AAENGNLEIVKLL 238
PHA03247 super family cl33720
large tegument protein UL36; Provisional
87-327 1.25e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.49  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   87 PPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSA-----PSELQHTPETLPSEVTQVEAPSGS 161
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplppPTSAQPTAPPPPPGPPPPSLPLGG 2854
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  162 APQPGG--------------PEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCMLPvrcvvpgPAA 227
Cdd:PHA03247 2855 SVAPGGdvrrrppsrspaakPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP-------PPP 2927
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  228 LRIRAEEQGLRRQRSEEPSPRGSPMLLRRLSVEESGLGlHLGPGRSPhlrrlsraGPRLLSPDteemPVAPLPSPAVPLE 307
Cdd:PHA03247 2928 QPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG-ALVPGRVA--------VPRFRVPQ----PAPSREAPASSTP 2994
                         250       260
                  ....*....|....*....|
gi 152031554  308 PTEHEWLVRTASGRWSHQLH 327
Cdd:PHA03247 2995 PLTGHSLSRVSSWASSLALH 3014
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
345-437 6.91e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.15  E-value: 6.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 345 GFTALHWAAKNGDREMALQLVEvarrggAPVDVNARSHGGYTPLHLAALHGHEDAAVLLvVRLGAQVHVRDYSGRRAYQY 424
Cdd:COG0666  153 GNTPLHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLL-LEAGADVNAKDNDGKTALDL 225
                         90
                 ....*....|...
gi 152031554 425 LRPGSSYALRRLL 437
Cdd:COG0666  226 AAENGNLEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
345-415 2.57e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 2.57e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 152031554  345 GFTALHWAAKNGDREMALQLVEVArrggapvDVNARSHGgYTPLHLAALHGHEDaAVLLVVRLGAQVHVRD 415
Cdd:pfam12796  30 GRTALHLAAKNGHLEIVKLLLEHA-------DVNLKDNG-RTALHYAARSGHLE-IVKLLLEKGADINVKD 91
PHA03247 PHA03247
large tegument protein UL36; Provisional
87-327 1.25e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.49  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   87 PPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSA-----PSELQHTPETLPSEVTQVEAPSGS 161
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplppPTSAQPTAPPPPPGPPPPSLPLGG 2854
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  162 APQPGG--------------PEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCMLPvrcvvpgPAA 227
Cdd:PHA03247 2855 SVAPGGdvrrrppsrspaakPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP-------PPP 2927
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  228 LRIRAEEQGLRRQRSEEPSPRGSPMLLRRLSVEESGLGlHLGPGRSPhlrrlsraGPRLLSPDteemPVAPLPSPAVPLE 307
Cdd:PHA03247 2928 QPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG-ALVPGRVA--------VPRFRVPQ----PAPSREAPASSTP 2994
                         250       260
                  ....*....|....*....|
gi 152031554  308 PTEHEWLVRTASGRWSHQLH 327
Cdd:PHA03247 2995 PLTGHSLSRVSSWASSLALH 3014
PHA03095 PHA03095
ankyrin-like protein; Provisional
331-419 6.78e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.87  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 331 LRDRGLAAKRDFMSGFTALHWAAKNGD--REMALQLVEvarrggAPVDVNARSHGGYTPLHLAALHGHeDAAVLLVVRLG 408
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLI------AGISINARNRYGQTPLHYAAVFNN-PRACRRLIALG 280
                         90
                 ....*....|.
gi 152031554 409 AQVHVRDYSGR 419
Cdd:PHA03095 281 ADINAVSSDGN 291
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
384-413 3.87e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.87e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 152031554   384 GYTPLHLAALHGHEDAAVLLvVRLGAQVHV 413
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLL-LDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
341-418 5.68e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 341 DFMSGFTALHWAAKNGDremaLQLVEVARRGGAPVdVNARSHG-------------GYTPLHLAALHGHEDAAVLLVVRl 407
Cdd:cd22192   85 DLYQGETALHIAVVNQN----LNLVRELIARGADV-VSPRATGtffrpgpknliyyGEHPLSFAACVGNEEIVRLLIEH- 158
                         90
                 ....*....|.
gi 152031554 408 GAQVHVRDYSG 418
Cdd:cd22192  159 GADIRAQDSLG 169
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
345-437 6.91e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.15  E-value: 6.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 345 GFTALHWAAKNGDREMALQLVEvarrggAPVDVNARSHGGYTPLHLAALHGHEDAAVLLvVRLGAQVHVRDYSGRRAYQY 424
Cdd:COG0666  153 GNTPLHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLL-LEAGADVNAKDNDGKTALDL 225
                         90
                 ....*....|...
gi 152031554 425 LRPGSSYALRRLL 437
Cdd:COG0666  226 AAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
344-421 1.72e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 74.22  E-value: 1.72e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 152031554 344 SGFTALHWAAKNGDREMALQLVEvarrGGApvDVNARSHGGYTPLHLAALHGHEDAAVLLvVRLGAQVHVRDYSGRRA 421
Cdd:COG0666  119 DGETPLHLAAYNGNLEIVKLLLE----AGA--DVNAQDNDGNTPLHLAAANGNLEIVKLL-LEAGADVNARDNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
329-421 2.99e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.45  E-value: 2.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 329 LLLRDRGLAAKRDFMSGFTALHWAAKNGDREMALQLVEvarrggAPVDVNARSHGGYTPLHLAALHGHEDAAVLLvVRLG 408
Cdd:COG0666   71 LLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE------AGADVNARDKDGETPLHLAAYNGNLEIVKLL-LEAG 143
                         90
                 ....*....|...
gi 152031554 409 AQVHVRDYSGRRA 421
Cdd:COG0666  144 ADVNAQDNDGNTP 156
Ank_2 pfam12796
Ankyrin repeats (3 copies);
345-415 2.57e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 2.57e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 152031554  345 GFTALHWAAKNGDREMALQLVEVArrggapvDVNARSHGgYTPLHLAALHGHEDaAVLLVVRLGAQVHVRD 415
Cdd:pfam12796  30 GRTALHLAAKNGHLEIVKLLLEHA-------DVNLKDNG-RTALHYAARSGHLE-IVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
345-437 6.91e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 6.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 345 GFTALHWAAKNGDREMALQLVEvarrGGApvDVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDYSGRRAYQY 424
Cdd:COG0666  186 GETPLHLAAENGHLEIVKLLLE----AGA--DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259
                         90
                 ....*....|...
gi 152031554 425 LRPGSSYALRRLL 437
Cdd:COG0666  260 AAAGAALIVKLLL 272
PHA03247 PHA03247
large tegument protein UL36; Provisional
87-327 1.25e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.49  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   87 PPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSA-----PSELQHTPETLPSEVTQVEAPSGS 161
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplppPTSAQPTAPPPPPGPPPPSLPLGG 2854
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  162 APQPGG--------------PEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCMLPvrcvvpgPAA 227
Cdd:PHA03247 2855 SVAPGGdvrrrppsrspaakPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP-------PPP 2927
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  228 LRIRAEEQGLRRQRSEEPSPRGSPMLLRRLSVEESGLGlHLGPGRSPhlrrlsraGPRLLSPDteemPVAPLPSPAVPLE 307
Cdd:PHA03247 2928 QPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG-ALVPGRVA--------VPRFRVPQ----PAPSREAPASSTP 2994
                         250       260
                  ....*....|....*....|
gi 152031554  308 PTEHEWLVRTASGRWSHQLH 327
Cdd:PHA03247 2995 PLTGHSLSRVSSWASSLALH 3014
Ank_2 pfam12796
Ankyrin repeats (3 copies);
349-404 7.49e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 7.49e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 152031554  349 LHWAAKNGDREMALQLVEvarrggAPVDVNARSHGGYTPLHLAALHGHEDAAVLLV 404
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLL 50
Ank_4 pfam13637
Ankyrin repeats (many copies);
347-404 2.37e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.35  E-value: 2.37e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 152031554  347 TALHWAAKNGDREMALQLVEvarrggAPVDVNARSHGGYTPLHLAALHGHEDAAVLLV 404
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLE------KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03247 PHA03247
large tegument protein UL36; Provisional
81-340 3.09e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 3.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   81 LRKKPRPPEGPE-APLPSSPGVPAALAQCAA-----------VPAEDNCAPGAPHSPQRSGEPPEDSSAPSElqhTPETL 148
Cdd:PHA03247 2698 LADPPPPPPTPEpAPHALVSATPLPPGPAAArqaspalpaapAPPAVPAGPATPGGPARPARPPTTAGPPAP---APPAA 2774
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  149 PSEVTQVEAP-------SGSAPQPGGPEDPALPRSSELARPASVPSGLALTSTESP--GPEPAPPTAQVPPQKPCMLPVR 219
Cdd:PHA03247 2775 PAAGPPRRLTrpavaslSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPptSAQPTAPPPPPGPPPPSLPLGG 2854
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  220 CVVPGpAALRIRAEEQGLRRQRSEEPSPRGSPMLLRRLSVEESGLGL---HLGPGRSPHLRRLSRAGPRLLSPDTEEMPV 296
Cdd:PHA03247 2855 SVAPG-GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALppdQPERPPQPQAPPPPQPQPQPPPPPQPQPPP 2933
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 152031554  297 APLPSPAVPLEPTEHEWLVRTASGRWSHQLHGLLLRDRGLAAKR 340
Cdd:PHA03247 2934 PPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRF 2977
PHA03095 PHA03095
ankyrin-like protein; Provisional
331-419 6.78e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.87  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 331 LRDRGLAAKRDFMSGFTALHWAAKNGD--REMALQLVEvarrggAPVDVNARSHGGYTPLHLAALHGHeDAAVLLVVRLG 408
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLI------AGISINARNRYGQTPLHYAAVFNN-PRACRRLIALG 280
                         90
                 ....*....|.
gi 152031554 409 AQVHVRDYSGR 419
Cdd:PHA03095 281 ADINAVSSDGN 291
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
91-251 7.51e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.72  E-value: 7.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  91 PEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPS--EVTQVEAPSGSAPQPGGP 168
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAarQASARGPGGAPAPAPAPA 455
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 169 EDPALPRSSELARPASVP-SGLALTSTESPGPEPAPPTAQVPP--QKPCMLPVRCVVPGPAALRIRAEEQGLRRQRSEEP 245
Cdd:PRK12323 456 AAPAAAARPAAAGPRPVAaAAAAAPARAAPAAAPAPADDDPPPweELPPEFASPAPAQPDAAPAGWVAESIPDPATADPD 535

                 ....*.
gi 152031554 246 SPRGSP 251
Cdd:PRK12323 536 DAFETL 541
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
83-213 1.45e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.15  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  83 KKPRPPEGPEAPL--PSSPGVPAAlAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSg 160
Cdd:PTZ00449 506 KHDEPPEGPEASGlpPKAPGDKEG-EEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPK- 583
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 152031554 161 sapQPGGPEDPALPRSSELARPASVP----------------SGLALTSTESPgPEPAPPTAQVPPQKP 213
Cdd:PTZ00449 584 ---DPKHPKDPEEPKKPKRPRSAQRPtrpkspklpelldipkSPKRPESPKSP-KRPPPPQRPSSPERP 648
PHA03247 PHA03247
large tegument protein UL36; Provisional
85-310 1.80e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   85 PRPPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQH-TPETLPSEVTQVEAPSGSAP 163
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRpRRRAARPTVGSLTSLADPPP 2703
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  164 QPGGPEDPALPRSSELARPASVPSGLAL--------------TSTESPGPEPAPPTAQVPPQKPCMLPVRCVVPGPAALR 229
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQAspalpaapappavpAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL 2783
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  230 IRAEEQGLRRQRSEEPSPRgspmllrrlsveESGLGLHLGPGRSPHLRRLSRAGPrLLSPDTEEMPVAPlPSPAVPLEPT 309
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPW------------DPADPPAAVLAPAAALPPAASPAG-PLPPPTSAQPTAP-PPPPGPPPPS 2849

                  .
gi 152031554  310 E 310
Cdd:PHA03247 2850 L 2850
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
329-424 3.62e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 45.72  E-value: 3.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 329 LLLRDRGLAAKRDFMSGFTALHWAAKNGDREMALQLVEvarrggAPVDVNARSHGGYTPLHLAALHGHEDAAVLLVvRLG 408
Cdd:COG0666   38 LLLLLALLALALADALGALLLLAAALAGDLLVALLLLA------AGADINAKDDGGNTLLHAAARNGDLEIVKLLL-EAG 110
                         90
                 ....*....|....*.
gi 152031554 409 AQVHVRDYSGRRAYQY 424
Cdd:COG0666  111 ADVNARDKDGETPLHL 126
Ank_5 pfam13857
Ankyrin repeats (many copies);
345-391 6.44e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 6.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 152031554  345 GFTALHWAAKNGDREMALQLVEvarrggAPVDVNARSHGGYTPLHLA 391
Cdd:pfam13857  16 GYTPLHVAAKYGALEIVRVLLA------YGVDLNLKDEEGLTALDLA 56
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
75-235 1.13e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 44.86  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  75 GVKFVVLR----------KKPRPPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPhSPQRSGEPPEDSSAPSELQHT 144
Cdd:PRK07994 348 GVEMTLLRmlafhpaaplPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPAS-APQQAPAVPLPETTSQLLAAR 426
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 145 PEtLPSEVTQVEAPSGSAPQPGGPEdpalPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCMLPVRcvvpg 224
Cdd:PRK07994 427 QQ-LQRAQGATKAKKSEPAAASRAR----PVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVAT----- 496
                        170
                 ....*....|.
gi 152031554 225 PAALRIRAEEQ 235
Cdd:PRK07994 497 PKALKKALEHE 507
PHA03247 PHA03247
large tegument protein UL36; Provisional
87-308 1.20e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   87 PPEGPEAPLPSSPGVPAALAQCA---AVP-------------AEDNCAPGAPHSPQRSGEPPEDSSAPSElQHTPETLPS 150
Cdd:PHA03247 2502 GPPDPDAPPAPSRLAPAILPDEPvgePVHprmltwirgleelASDDAGDPPPPLPPAAPPAAPDRSVPPP-RPAPRPSEP 2580
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  151 EVTQVEAPSGSAPQPGGPEDPALPRSSELARPASVPSGLALTSTESPGPEPAP-----PTAQVPPQKPCMLPVRCVVPGP 225
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPaanepDPHPPPTVPPPERPRDDPAPGR 2660
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  226 AALRIRAEEQGlRRQRSEEPSPRGSPMLLRRLSVEESGLGLHLGPGRSPHLRRLSRAGPRLLSPDTEEMPVAPLPSPAVP 305
Cdd:PHA03247 2661 VSRPRRARRLG-RAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                  ...
gi 152031554  306 LEP 308
Cdd:PHA03247 2740 APP 2742
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
354-421 1.24e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.86  E-value: 1.24e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 152031554 354 KNGDREMALQLVEVARRGG---------APVDVNARSHGGYTPLHLAALHGHEDaAVLLVVRLGAQVHVRDYSGRRA 421
Cdd:PLN03192 519 EHDDPNMASNLLTVASTGNaalleellkAKLDPDIGDSKGRTPLHIAASKGYED-CVLVLLKHACNVHIRDANGNTA 594
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
88-251 1.46e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  88 PEGPEAPLPSSPGVPAALAQCAAVPAEDnCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSGSAPQPGG 167
Cdd:PRK07003 456 RASADSRCDERDAQPPADSGSASAPASD-APPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARP 534
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 168 PEdPALPRSSELARPASVP------SGLALTSTES--PGPEPAPPTAQVPPQKPCMLPVRCVVPGPAALRIRAEEQGLRR 239
Cdd:PRK07003 535 PT-PAAAAPAARAGGAAAAldvlrnAGMRVSSDRGarAAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGA 613
                        170
                 ....*....|..
gi 152031554 240 QRSEEPSPRGSP 251
Cdd:PRK07003 614 ARAEQAAESRGA 625
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
95-227 1.64e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  95 LPSSPGVPAALAQCA------AVPAEDNCAPGAPHSPQRSGEPPEDSSAPSElqhTPETLPSEVTQVEAPSGSAPQPGGP 168
Cdd:PRK07764 364 LPSASDDERGLLARLerlerrLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAA---APAAAAAPAPAAAPQPAPAPAPAPA 440
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 152031554 169 EDPALPRSSELARPASVPSGlalTSTESPGPEPAPPTAQVPPQKPCMLPVRCVVPGPAA 227
Cdd:PRK07764 441 PPSPAGNAPAGGAPSPPPAA---APSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA 496
Ank_5 pfam13857
Ankyrin repeats (many copies);
374-424 1.86e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 1.86e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 152031554  374 PVDVNARSHGGYTPLHLAALHGHEDAAVLLVVRlGAQVHVRDYSGRRAYQY 424
Cdd:pfam13857   6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTALDL 55
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
104-249 2.00e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.00  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 104 ALAQCAAVPAEDNCAPGAPHspqrsgepPEDSSAPSELQHTPETLPSEVTqveAPSGSAPQPGGPEDPALPRSSELARPA 183
Cdd:PRK14971 355 TLIQLAQLTQKGDDASGGRG--------PKQHIKPVFTQPAAAPQPSAAA---AASPSPSQSSAAAQPSAPQSATQPAGT 423
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 152031554 184 SVPsglalTSTESPGPEPAPPTAQVPPQKPcmlPVRCVVPGPAAL-RIRAEEQGLRR-QRSEEPSPRG 249
Cdd:PRK14971 424 PPT-----VSVDPPAAVPVNPPSTAPQAVR---PAQFKEEKKIPVsKVSSLGPSTLRpIQEKAEQATG 483
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
87-309 2.34e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  87 PPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQ----VEAPSGSA 162
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATadrgDDAADGDA 447
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 163 PQPGGPEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCMLPVRCVVPGPAALRIraeeqglrRQRS 242
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAA--------ASRE 519
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 152031554 243 EEPSPRGSPMLLRRLSVEESGLGLHLGPGRSPHLRRLSRAGPRLLSPDTEEMPVAPLPSPAVPLEPT 309
Cdd:PRK07003 520 DAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPK 586
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
79-259 3.29e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  79 VVLRKKPRPPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPS------------ELQHTPE 146
Cdd:PRK12323 395 AAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAaapaaaarpaaaGPRPVAA 474
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 147 TLPSEVTQVEAPSGSAPQPGGP----EDPALPRSSELARPASVPSGLALTSTESPGPEPAPPT----AQVPPQKPCMLPV 218
Cdd:PRK12323 475 AAAAAPARAAPAAAPAPADDDPppweELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAfetlAPAPAAAPAPRAA 554
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 152031554 219 RCVVPGPAALRIRAEEQGLrrqrsEEPSPRGSPMLLRRLSV 259
Cdd:PRK12323 555 AATEPVVAPRPPRASASGL-----PDMFDGDWPALAARLPV 590
PHA03247 PHA03247
large tegument protein UL36; Provisional
86-233 5.03e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 5.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   86 RPPEGPEAPLPSSPGVPAA--LAQCAAVPAEDNCA-PGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSGSA 162
Cdd:PHA03247 2865 RPPSRSPAAKPAAPARPPVrrLARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLA 2944
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 152031554  163 PQPG-GPEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCMLPVRCVVPGPAALRIRAE 233
Cdd:PHA03247 2945 PTTDpAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
85-205 5.52e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.91  E-value: 5.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  85 PRPPEGPEAPlPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSGSAPQ 164
Cdd:PRK07003 417 AAAATRAEAP-PAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPR 495
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 152031554 165 PGGPEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPT 205
Cdd:PRK07003 496 AAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPT 536
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
72-214 5.82e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.78  E-value: 5.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  72 ELDGVKFVVLRK---KPRPPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPqrsgePPEDSSAPSELQHTPETL 148
Cdd:PRK14951 350 EYAALTMVLLRLlafKPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAA-----PAAAASAPAAPPAAAPPA 424
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 152031554 149 PSEVTQVEAPsgSAPQPGGPEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPC 214
Cdd:PRK14951 425 PVAAPAAAAP--AAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARL 488
PHA02874 PHA02874
ankyrin repeat protein; Provisional
347-441 6.32e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.26  E-value: 6.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 347 TALHWAAKNGDREMALQLVEVArrggapVDVNARSHGGYTPLHLAALHGHEDAAVLLVVRlGAQVHVRDYSGRRAYQYLR 426
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYG------ADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEK-GAYANVKDNNGESPLHNAA 198
                         90
                 ....*....|....*
gi 152031554 427 PGSSYALRRLLGDPG 441
Cdd:PHA02874 199 EYGDYACIKLLIDHG 213
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
384-415 7.37e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 7.37e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 152031554  384 GYTPLHLAALH-GHEDAAVLLvVRLGAQVHVRD 415
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLL-LSKGADVNARD 33
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
87-251 7.98e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 7.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   87 PPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPS------- 159
Cdd:PHA03307   28 PGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASParegspt 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  160 ----------GSAPQPGGPEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCMLP-------VRCVV 222
Cdd:PHA03307  108 ppgpsspdppPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPlsspeetARAPS 187
                         170       180
                  ....*....|....*....|....*....
gi 152031554  223 PGPAALRIRAEEQGLRRQRSEEPSPRGSP 251
Cdd:PHA03307  188 SPPAEPPPSTPPAAASPRPPRRSSPISAS 216
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
83-305 8.47e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 8.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   83 KKPRPPEGPEAPLPSSPGVPAALAQcAAVPAEdncaPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSGSA 162
Cdd:PHA03307   95 LAPASPAREGSPTPPGPSSPDPPPP-TPPPAS----PPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASS 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  163 PQPGgpedPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCMLPVRCVVPGPAALRIRAEEQGLRRQRS 242
Cdd:PHA03307  170 RQAA----LPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESS 245
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 152031554  243 ------EEPSPRGSPMLLRRLSVEESGLGLHlgPGRSPHLRRLSRAGPRLLSPDTEemPVAPLPSPAVP 305
Cdd:PHA03307  246 gcgwgpENECPLPRPAPITLPTRIWEASGWN--GPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPS 310
PHA02876 PHA02876
ankyrin repeat protein; Provisional
331-424 1.08e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.97  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 331 LRDRGLAAKRDFMSGFTALHWAAKNG-DREMALQLVEvarRGGapvDVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGA 409
Cdd:PHA02876 293 LLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIM---LGA---DVNAADRLYITPLHQASTLDRNKDIVITLLELGA 366
                         90
                 ....*....|....*
gi 152031554 410 QVHVRDYSGRRAYQY 424
Cdd:PHA02876 367 NVNARDYCDKTPIHY 381
PRK10263 PRK10263
DNA translocase FtsK; Provisional
91-251 1.16e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   91 PEAPLPSSPGVPAALAQCAAVPAEDNCAPGaPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQveapsgsAPQPGGPED 170
Cdd:PRK10263  336 PVEPVTQTPPVASVDVPPAQPTVAWQPVPG-PQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQ-------QPVQPQQPY 407
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  171 PALPRSSELARPASVPSGLALTSTESPGPEPAPPTA----QVPPQKPCMLPVRCVVPGPAALRIRAEEQGLRRQRSEEPS 246
Cdd:PRK10263  408 YAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAgnawQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQ 487

                  ....*
gi 152031554  247 PRGSP 251
Cdd:PRK10263  488 PVVEP 492
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
88-213 1.47e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  88 PEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSGSAPQPGG 167
Cdd:PRK07764 615 PAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPA 694
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 152031554 168 PEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKP 213
Cdd:PRK07764 695 GAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
83-251 1.65e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  83 KKPRPPEGPEAPLPSSPgvPAALAQCAAVPAEDncAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSGSA 162
Cdd:PRK07764 592 PGAAGGEGPPAPASSGP--PEEAARPAAPAAPA--APAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 163 PQPGGPEDPALPRSSELARPASVPSGlalTSTESPGPEPAPPTAQVPPQKPCMLPVRCVVPGPAALRIRAEEQGLRRQRS 242
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAAPAAP---AGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPE 744

                 ....*....
gi 152031554 243 EEPSPRGSP 251
Cdd:PRK07764 745 PDDPPDPAG 753
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
86-251 2.07e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  86 RPPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSP--------QRSGEPPEDSSAPselqhTPETLPSEVTQVEA 157
Cdd:PRK12323 390 AAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPApealaaarQASARGPGGAPAP-----APAPAAAPAAAARP 464
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 158 PSGSAPQPGGPEDPALPRSSELARPASVPSGLAlTSTESPGPEPAPPTAQVPPQKPCMLPVRCVVPGPAALRIRAEEQGL 237
Cdd:PRK12323 465 AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP-PWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAP 543
                        170
                 ....*....|....
gi 152031554 238 RRQRSEEPSPRGSP 251
Cdd:PRK12323 544 APAAAPAPRAAAAT 557
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
174-446 2.19e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 174 PRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPcmlPVRCVVPGPAALRIRAEeqglrrqrseePSPRGSPML 253
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAA---APAAAASAPAAPPAAAP-----------PAPVAAPAA 431
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 254 LRRLSVEESGLG-LHLGPGRSPHLRRLSRAGPRLLSPDTEeMPVAPLPSPAVPLEPTehewLVRTASGRWSHQLHGLLLR 332
Cdd:PRK14951 432 AAPAAAPAAAPAaVALAPAPPAQAAPETVAIPVRVAPEPA-VASAAPAPAAAPAAAR----LTPTEEGDVWHATVQQLAA 506
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 333 D---RGLAakrdfmsgftalhwaakngdREMALQLVEVARRGGA---PVDVNARSHGGYTPLHLAALHGHEDAAVLLVVR 406
Cdd:PRK14951 507 AeaiTALA--------------------RELALQSELVARDGDQwllRVERESLNQPGARERLRAALEAALGHAVRLEVE 566
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 152031554 407 LGAqvhVRDYSGRRAYQYLRPGSSYALRRLLGDPGLRSMM 446
Cdd:PRK14951 567 VGA---VTDSPARRNAAARAERQREAEEIIRNDPFVQQLM 603
PHA03379 PHA03379
EBNA-3A; Provisional
85-321 2.58e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.81  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  85 PRPPEGPEAPLPSSPGVPA-ALAQCAAVPAEDN--CAPGAPHSPQRSGEPPedssAPSELQHTP-ETLPSEVTQVEAPSG 160
Cdd:PHA03379 471 PPGPLQDLEPGDQLPGVVQdGRPACAPVPAPAGpiVRPWEASLSQVPGVAF----APVMPQPMPvEPVPVPTVALERPVC 546
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 161 SAPQPGGPEDPALPRSSELARpasvpsglaltstESPGPEPAPPTaqvPPQKPCMLPVRCvvpGPAalRIRAEEQGlrRQ 240
Cdd:PHA03379 547 PAPPLIAMQGPGETSGIVRVR-------------ERWRPAPWTPN---PPRSPSQMSVRD---RLA--RLRAEAQP--YQ 603
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 241 RSEEPSPRGSPM------LLRRLSVEE--------SGLGLHLGPGRSPHLRRLSRAGPrLLSPDTEEMPVAPLPSPAVPL 306
Cdd:PHA03379 604 ASVEVQPPQLTQvspqqpMEYPLEPEQqmfpgspfSQVADVMRAGGVPAMQPQYFDLP-LQQPISQGAPLAPLRASMGPV 682
                        250
                 ....*....|....*...
gi 152031554 307 EP---TEHEWLVRTASGR 321
Cdd:PHA03379 683 PPvpaTQPQYFDIPLTEP 700
PHA03095 PHA03095
ankyrin-like protein; Provisional
372-426 2.87e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 2.87e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 152031554 372 GApvDVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDYSGRRAYQ-YLR 426
Cdd:PHA03095  73 GA--DVNAPERCGFTPLHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHvYLS 126
PRK12495 PRK12495
hypothetical protein; Provisional
113-197 3.15e-03

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 39.47  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 113 AEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSGSA------------PQPGGPEDPALPRSSELA 180
Cdd:PRK12495  78 AGDGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSATDEAAtdppataaardgPTPDPTAQPATPDERRSP 157
                         90
                 ....*....|....*..
gi 152031554 181 RPASVPSGLALTSTESP 197
Cdd:PRK12495 158 RQRPPVSGEPPTPSTPD 174
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
143-250 3.41e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.18  E-value: 3.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 143 HTPETLPSEVTQVEA--PSGSAPQPGGPEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCMLPVRC 220
Cdd:PRK14950 344 TSYGQLPLELAVIEAllVPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPH 423
                         90       100       110
                 ....*....|....*....|....*....|
gi 152031554 221 VVPGPAALRiRAEEQGLRRQRSEEPSPRGS 250
Cdd:PRK14950 424 TPESAPKLT-RAAIPVDEKPKYTPPAPPKE 452
PRK10263 PRK10263
DNA translocase FtsK; Provisional
89-175 3.74e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   89 EGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPS---EVTQVEAPSGSAPQP 165
Cdd:PRK10263  738 DGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVApqpQYQQPQQPVAPQPQY 817
                          90
                  ....*....|
gi 152031554  166 GGPEDPALPR 175
Cdd:PRK10263  818 QQPQQPVAPQ 827
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
384-413 3.87e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.87e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 152031554   384 GYTPLHLAALHGHEDAAVLLvVRLGAQVHV 413
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLL-LDKGADINA 30
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
88-207 4.03e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 4.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  88 PEGPEAPLPSSPGVPAAlaqcAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSGSAPQPGG 167
Cdd:PRK07764 392 GAPAAAAPSAAAAAPAA----APAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPA 467
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 152031554 168 PEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQ 207
Cdd:PRK07764 468 PAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGAD 507
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
47-302 4.25e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   47 AGDPRGRAARRDRFKqfvnnvAVVKELDGVKFVVLRKKPRPPEGPEAPLPSSPGVPAALAQCA-AVPAEDNCAPGAPHSP 125
Cdd:PHA03307  217 ASSPAPAPGRSAADD------AGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASgWNGPSSRPGPASSSSS 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  126 QRSGEPPEDSSAPSELQHTPETLPSEvtqveapSGSAPQPGGPEDPAlpRSSELARPASVPSGLALTSTESPGPEPAPPT 205
Cdd:PHA03307  291 PRERSPSPSPSSPGSGPAPSSPRASS-------SSSSSRESSSSSTS--SSSESSRGAAVSPGPSPSRSPSPSRPPPPAD 361
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  206 AQVPPQKPcmlPVRCVVPGPAALRIRAEEQGLRRQRSEEPSPRGSPMLLRRLSVEESGLGLHLGPGRSPhlrrlsrAGPR 285
Cdd:PHA03307  362 PSSPRKRP---RPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFY-------ARYP 431
                         250
                  ....*....|....*..
gi 152031554  286 LLSPDTEEMPVAPLPSP 302
Cdd:PHA03307  432 LLTPSGEPWPGSPPPPP 448
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
91-211 4.87e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  91 PEAPLPSSPGVPAALAQCAAVPAEdncAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSGSAPQPGGPED 170
Cdd:PRK07764 394 PAAAAPSAAAAAPAAAPAPAAAAP---AAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAP 470
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 152031554 171 PALPRSSELARPASVPSGLALTSTEspgpEPAPPTAQVPPQ 211
Cdd:PRK07764 471 AAAPEPTAAPAPAPPAAPAPAAAPA----APAAPAAPAGAD 507
PHA03291 PHA03291
envelope glycoprotein I; Provisional
87-310 5.60e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 39.17  E-value: 5.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  87 PPEGPEAPLPSSPGV------PAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSG 160
Cdd:PHA03291 167 PAEGTLAAPPLGEGSadgscdPALPLSAPRLGPADVFVPATPRPTPRTTASPETTPTPSTTTSPPSTTIPAPSTTIAAPQ 246
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 161 SAPQPGGPEDPAlprsselarPASVPSGLALTSTESPGPEP---APPTAQVPPQKPCMLPVRCVVPGPAALRIRaeeqgl 237
Cdd:PHA03291 247 AGTTPEAEGTPA---------PPTPGGGEAPPANATPAPEAsryELTVTQIIQIAIPASIIACVFLGSCACCLH------ 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 238 RRQRSEEPSPR-----GSPMLLRRLSVEESGLG-----LHLGPGRSPHL--RRLSR-AGPRL--LSPDTEEMPVAPLPSP 302
Cdd:PHA03291 312 RRCRRRRRRPAriyrpPSPVAPSISAVNEAALArlgdeLKRHPPESPRRskRRSSQtMVPSLtaISEESEAPAVVELSRS 391

                 ....*...
gi 152031554 303 AVPLEPTE 310
Cdd:PHA03291 392 PRRPGGPT 399
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
341-418 5.68e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 341 DFMSGFTALHWAAKNGDremaLQLVEVARRGGAPVdVNARSHG-------------GYTPLHLAALHGHEDAAVLLVVRl 407
Cdd:cd22192   85 DLYQGETALHIAVVNQN----LNLVRELIARGADV-VSPRATGtffrpgpknliyyGEHPLSFAACVGNEEIVRLLIEH- 158
                         90
                 ....*....|.
gi 152031554 408 GAQVHVRDYSG 418
Cdd:cd22192  159 GADIRAQDSLG 169
PHA03247 PHA03247
large tegument protein UL36; Provisional
85-209 7.48e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 7.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554   85 PRPPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEAPSGSAPQ 164
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 152031554  165 PGGPED-----PALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVP 209
Cdd:PHA03247 2982 PAPSREapassTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPP 3031
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
71-213 9.25e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 38.94  E-value: 9.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  71 KELDGVKFVVLRKKPRPPEG-PEAPLPSSPGVPAALAQCAAVPAEDNCAP----GAPHSPQRSGEPPEDSSA-------P 138
Cdd:PRK14949 632 KEGDGKKSSADRKPKTPPSRaPPASLSKPASSPDASQTSASFDLDPDFELathqSVPEAALASGSAPAPPPVpdpydrpP 711
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 152031554 139 SELQHTPETLPSEVTQVEAPSGSAPQPGGPEDPALPRSSELARPASVP-SGLALTSTESPgPEPAPPTAQVPPQKP 213
Cdd:PRK14949 712 WEEAPEVASANDGPNNAAEGNLSESVEDASNSELQAVEQQATHQPQVQaEAQSPASTTAL-TQTSSEVQDTELNLV 786
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
85-236 9.35e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.06  E-value: 9.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554  85 PRPPEGPEAPL-PSSPGVPAALAQ------CAAVPAEDNCAPGAPHSPQRSGEPPEDSSAPSELQHTPETLPSEVTQVEA 157
Cdd:PRK07003 385 ARAAAAVGASAvPAVTAVTGAAGAalapkaAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCD 464
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152031554 158 PSGSAP--QPGGPEDPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCML---PVRCVVPGPAALRIRA 232
Cdd:PRK07003 465 ERDAQPpaDSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAappAPEARPPTPAAAAPAA 544

                 ....
gi 152031554 233 EEQG 236
Cdd:PRK07003 545 RAGG 548
Ank_2 pfam12796
Ankyrin repeats (3 copies);
337-366 9.50e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 35.48  E-value: 9.50e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 152031554  337 AAKRDFMSGFTALHWAAKNGDREMALQLVE 366
Cdd:pfam12796  53 ADVNLKDNGRTALHYAARSGHLEIVKLLLE 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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