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Conserved domains on  [gi|81876138|sp|Q8C261|]
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RecName: Full=Sodium/potassium/calcium exchanger 5; AltName: Full=Na(+)/K(+)/Ca(2+)-exchange protein 5; AltName: Full=Solute carrier family 24 member 5; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 291-501 5.04e-49

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 181.35  E-value: 5.04e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    291 EDPPSVFSMPEADLRRIFWVLSLPIITLLALTTPDCRRKFWKNYFVITFFMSALWISAFTYILVWMVTVTGETLGIPDTV 370
Cdd:TIGR00927  890 NEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEI 969

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    371 MGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDM-LCLGLPWFIkTAFTNASAPIEVNSKGLTYITISLNIS 449
Cdd:TIGR00927  970 MGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDItVGLPVPWLL-FSLINGLQPVPVSSNGLFCAIVLLFLM 1048

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 81876138    450 ILFLFLAVHFNGWKLDRKLGVVCLVLYLGLATLSVLYEigiignNRIRGCGV 501
Cdd:TIGR00927 1049 LLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLE------DRIISCPV 1094
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 20-229 1.23e-48

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 180.19  E-value: 1.23e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138     20 WVSAYLPVRGVSLPPRLPratgnSTQCAVSPASEFPEGFFTKQESTDGGIVIYFLIILYMCMAISIVCDKYFLPSLEIIS 99
Cdd:TIGR00927  413 LTTALFPEAPSPSPSALP-----PGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVIT 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    100 DSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLSCWPLFRDCAVY 179
Cdd:TIGR00927  488 DKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFY 567

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 81876138    180 AVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLCFDTTISRHVMKTCS 229
Cdd:TIGR00927  568 ILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLS 617
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 291-501 5.04e-49

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 181.35  E-value: 5.04e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    291 EDPPSVFSMPEADLRRIFWVLSLPIITLLALTTPDCRRKFWKNYFVITFFMSALWISAFTYILVWMVTVTGETLGIPDTV 370
Cdd:TIGR00927  890 NEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEI 969

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    371 MGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDM-LCLGLPWFIkTAFTNASAPIEVNSKGLTYITISLNIS 449
Cdd:TIGR00927  970 MGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDItVGLPVPWLL-FSLINGLQPVPVSSNGLFCAIVLLFLM 1048

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 81876138    450 ILFLFLAVHFNGWKLDRKLGVVCLVLYLGLATLSVLYEigiignNRIRGCGV 501
Cdd:TIGR00927 1049 LLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLE------DRIISCPV 1094
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 20-229 1.23e-48

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 180.19  E-value: 1.23e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138     20 WVSAYLPVRGVSLPPRLPratgnSTQCAVSPASEFPEGFFTKQESTDGGIVIYFLIILYMCMAISIVCDKYFLPSLEIIS 99
Cdd:TIGR00927  413 LTTALFPEAPSPSPSALP-----PGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVIT 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    100 DSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLSCWPLFRDCAVY 179
Cdd:TIGR00927  488 DKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFY 567

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 81876138    180 AVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLCFDTTISRHVMKTCS 229
Cdd:TIGR00927  568 ILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLS 617
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
94-478 5.97e-41

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 148.74  E-value: 5.97e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  94 SLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLScwPLF 173
Cdd:COG0530   7 GADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRR--VLR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138 174 RDCAVYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLcfdttisrhvmktcspccpclarameerieqqtllgwed 253
Cdd:COG0530  85 RDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL--------------------------------------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138 254 esqlfIRRQSRTDSGIFQEDSgysqlslslhglsqvsedppsvfsMPEADLRRIFWVLslpIITLLALTtpdcrrkfwkn 333
Cdd:COG0530 126 -----IRRARKEPAWEEVEEE------------------------LEEKPKMSLWKAL---LLLVLGLA----------- 162

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138 334 yfvitffmsALWISAftYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDML 413
Cdd:COG0530 163 ---------LLVVGA--RLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNIL 231

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81876138 414 -CLGLPWFIktaftnasAPIEVNSKGLTYITISLnISILFLFLAVHFNGWKLDRKLGVVCLVLYLG 478
Cdd:COG0530 232 lVLGIGALI--------TPIPVDPAVLSFDLPVM-LAATLLLLGLLRTGGRIGRWEGLLLLALYLA 288
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 334-485 1.11e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 94.21  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   334 YFVITFFMSALWISAFTYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDML 413
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81876138   414 -CLGLPWFIkTAFTNASAPIEVNSKGLTYITISLnisILFLFLAVHFNGWKLDRKLGVVCLVLYLGLATLSVL 485
Cdd:pfam01699  81 lVLGLSALI-GPVKVDSLLLKLDLGVLLLVALLL---LLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 72-216 7.48e-20

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 86.12  E-value: 7.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    72 YFLIILYMCMAISIVCDKYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLL 151
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81876138   152 ---GICAACGLLSNMVSTLSC-WPLFRDCAVYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLCF 216
Cdd:pfam01699  81 lvlGLSALIGPVKVDSLLLKLdLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
89-214 2.44e-15

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 76.33  E-value: 2.44e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  89 KYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMvsTLS 168
Cdd:COG0530 169 RLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPI--PVD 246

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 81876138 169 CWPLFRDCAVYAVSVGAVFGIIF-DNRIYWYEGAGLLLIYGLYVLLL 214
Cdd:COG0530 247 PAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLALYLAYLALL 293
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 358-486 4.63e-12

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 66.98  E-value: 4.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  358 TVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDM-LCLGLPWFIktaftnasAPIEVNS 436
Cdd:PRK10734 198 TVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIvIVLGLPALI--------SPGEINP 269

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 81876138  437 KGLTY-ITISLNISILFLFLAvhfngWKLDRKLGVVCLVLYLG--LATLSVLY 486
Cdd:PRK10734 270 LAFSRdYWVMLLVSVIFALLC-----WRRKRRIGRGAGALLLGgfIVWLAMLY 317
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 74-155 8.87e-06

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 47.72  E-value: 8.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   74 LIIlyMCMAISIVCDkyflpSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNL--- 150
Cdd:PRK10734 183 LII--MPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIviv 255


                 ....*
gi 81876138  151 LGICA 155
Cdd:PRK10734 256 LGLPA 260
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 291-501 5.04e-49

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 181.35  E-value: 5.04e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    291 EDPPSVFSMPEADLRRIFWVLSLPIITLLALTTPDCRRKFWKNYFVITFFMSALWISAFTYILVWMVTVTGETLGIPDTV 370
Cdd:TIGR00927  890 NEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEI 969

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    371 MGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDM-LCLGLPWFIkTAFTNASAPIEVNSKGLTYITISLNIS 449
Cdd:TIGR00927  970 MGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDItVGLPVPWLL-FSLINGLQPVPVSSNGLFCAIVLLFLM 1048

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 81876138    450 ILFLFLAVHFNGWKLDRKLGVVCLVLYLGLATLSVLYEigiignNRIRGCGV 501
Cdd:TIGR00927 1049 LLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLE------DRIISCPV 1094
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 20-229 1.23e-48

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 180.19  E-value: 1.23e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138     20 WVSAYLPVRGVSLPPRLPratgnSTQCAVSPASEFPEGFFTKQESTDGGIVIYFLIILYMCMAISIVCDKYFLPSLEIIS 99
Cdd:TIGR00927  413 LTTALFPEAPSPSPSALP-----PGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVIT 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    100 DSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLSCWPLFRDCAVY 179
Cdd:TIGR00927  488 DKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFY 567

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 81876138    180 AVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLCFDTTISRHVMKTCS 229
Cdd:TIGR00927  568 ILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLS 617
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 77-477 1.09e-42

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 153.63  E-value: 1.09e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    77 LYMCMAISIVCDKYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAA 156
Cdd:TIGR00367   7 LILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   157 CGLLSNMvsTLSCWPLFRDCAVYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLcfdttisrhvmktcspccpcla 236
Cdd:TIGR00367  87 SAIFSPI--IVDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFL---------------------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   237 rameerIEQQTLLGWEDESQlfirrqsrtdsgifqedsgysqlslslhglSQVSEDPPSVFsmpeadlrrIFWVLSLPII 316
Cdd:TIGR00367 143 ------VKNERWVKYDTYTE------------------------------ENLDENNRRPQ---------IFFSLVLLII 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   317 TLlalttpdcrrkfwknyfvitffmsaLWISAFTYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGK 396
Cdd:TIGR00367 178 GL-------------------------IGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGL 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   397 GDMAISNIVGSNVFDMLC-LGLPWFIktaftnasAPIEVNSKGLTYITISLNISILFLFLAVHFNGwKLDRKLGVVCLVL 475
Cdd:TIGR00367 233 GDIAVGNVIGSNIFNILVgLGVPSLF--------MPIPVEPLAYNLDAPVMVIVTLLLMLFFKTSM-KLGRWEGILLLAL 303


                  ..
gi 81876138   476 YL 477
Cdd:TIGR00367 304 YI 305
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
94-478 5.97e-41

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 148.74  E-value: 5.97e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  94 SLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLScwPLF 173
Cdd:COG0530   7 GADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRR--VLR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138 174 RDCAVYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLcfdttisrhvmktcspccpclarameerieqqtllgwed 253
Cdd:COG0530  85 RDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL--------------------------------------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138 254 esqlfIRRQSRTDSGIFQEDSgysqlslslhglsqvsedppsvfsMPEADLRRIFWVLslpIITLLALTtpdcrrkfwkn 333
Cdd:COG0530 126 -----IRRARKEPAWEEVEEE------------------------LEEKPKMSLWKAL---LLLVLGLA----------- 162

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138 334 yfvitffmsALWISAftYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDML 413
Cdd:COG0530 163 ---------LLVVGA--RLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNIL 231

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81876138 414 -CLGLPWFIktaftnasAPIEVNSKGLTYITISLnISILFLFLAVHFNGWKLDRKLGVVCLVLYLG 478
Cdd:COG0530 232 lVLGIGALI--------TPIPVDPAVLSFDLPVM-LAATLLLLGLLRTGGRIGRWEGLLLLALYLA 288
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 334-485 1.11e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 94.21  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   334 YFVITFFMSALWISAFTYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDML 413
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81876138   414 -CLGLPWFIkTAFTNASAPIEVNSKGLTYITISLnisILFLFLAVHFNGWKLDRKLGVVCLVLYLGLATLSVL 485
Cdd:pfam01699  81 lVLGLSALI-GPVKVDSLLLKLDLGVLLLVALLL---LLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 72-216 7.48e-20

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 86.12  E-value: 7.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    72 YFLIILYMCMAISIVCDKYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLL 151
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81876138   152 ---GICAACGLLSNMVSTLSC-WPLFRDCAVYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLCF 216
Cdd:pfam01699  81 lvlGLSALIGPVKVDSLLLKLdLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
89-214 2.44e-15

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 76.33  E-value: 2.44e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  89 KYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMvsTLS 168
Cdd:COG0530 169 RLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPI--PVD 246

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 81876138 169 CWPLFRDCAVYAVSVGAVFGIIF-DNRIYWYEGAGLLLIYGLYVLLL 214
Cdd:COG0530 247 PAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLALYLAYLALL 293
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 358-486 4.63e-12

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 66.98  E-value: 4.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  358 TVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDM-LCLGLPWFIktaftnasAPIEVNS 436
Cdd:PRK10734 198 TVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIvIVLGLPALI--------SPGEINP 269

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 81876138  437 KGLTY-ITISLNISILFLFLAvhfngWKLDRKLGVVCLVLYLG--LATLSVLY 486
Cdd:PRK10734 270 LAFSRdYWVMLLVSVIFALLC-----WRRKRRIGRGAGALLLGgfIVWLAMLY 317
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 70-157 8.26e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 64.81  E-value: 8.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    70 VIYFLIILYMCMAISIVCDKyFLPSLEIISdslglSQD-----------------------VAGATFMAAGSSAPELVTA 126
Cdd:TIGR00845  76 TVYFVAMVYMFLGVSIIADR-FMASIEVIT-----SQEkeitikkpngettvttvriwnetVSNLTLMALGSSAPEILLS 149

                          90       100       110
                  ....*....|....*....|....*....|....
gi 81876138   127 FLGVF---ITKGDIGISTILGSAIYNLLGICAAC 157
Cdd:TIGR00845 150 VIEVCghnFEAGDLGPSTIVGSAAFNMFIIIAIC 183
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 330-421 9.12e-08

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 54.80  E-value: 9.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   330 FWKNYFV-----------ITFFMSALWISAFTYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKG- 397
Cdd:TIGR00845 739 FWKVLFAfvppteywggwACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYa 818

                          90       100
                  ....*....|....*....|....*..
gi 81876138   398 DMAISNIVGS---NVFdmLCLGLPWFI 421
Cdd:TIGR00845 819 DASIGNVTGSnavNVF--LGIGVAWSI 843
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 353-436 1.29e-06

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 50.41  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  353 LVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFD-MLCLGLPWFIKtaftnasaP 431
Cdd:PRK10734  22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNiLLILGLAALIR--------P 93


                 ....*
gi 81876138  432 IEVNS 436
Cdd:PRK10734  94 FTVHS 98
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 74-155 8.87e-06

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 47.72  E-value: 8.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   74 LIIlyMCMAISIVCDkyflpSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNL--- 150
Cdd:PRK10734 183 LII--MPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIviv 255


                 ....*
gi 81876138  151 LGICA 155
Cdd:PRK10734 256 LGLPA 260
caca2 TIGR00846
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the ...
 73-213 1.37e-05

calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is generated from the calcium ion/proton exchangers of the CacA family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273297 [Multi-domain]  Cd Length: 363  Bit Score: 47.45  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    73 FLIILYMCMAIsIVCDKYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIynllg 152
Cdd:TIGR00846 221 AAWLVGTTIAI-ILLADYLVDTIDDAVDSWGLSVAFIGLILAPIVGNAAEHVTAVKAALKNKLDLALGVALGSAL----- 294

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   153 icaACGLLSNMVSTLSCWPLFRDCA---------VYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLL 213
Cdd:TIGR00846 295 ---QIILFVVPLVVLVAWMLGIPMDlnfgtfetiVLALSLFLTTITLQDGRSNYLEGAVLLALYIIIAMA 361
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 70-161 2.15e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 46.55  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    70 VIYFLIILYMC-MAISIVCDKYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIY 148
Cdd:TIGR00367 167 QIFFSLVLLIIgLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIF 246

                          90
                  ....*....|...
gi 81876138   149 NLLGICAACGLLS 161
Cdd:TIGR00367 247 NILVGLGVPSLFM 259
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 274-413 4.64e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 46.14  E-value: 4.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    274 SGYSQLSLSLHGLSQVSEDPPSVFSMPEadlRRIFWVLsLPIitllalttpdcrrkfwknyFVITFFMSALWISAFTYiL 353
Cdd:TIGR00927  424 PSPSALPPGQPDLHPKAEYPPDLFSVEE---RRQGWVV-LHI-------------------FGMMYVFVALAIVCDEY-F 479

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138    354 VWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDML 413
Cdd:TIGR00927  480 VPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNIL 539
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 90-491 6.13e-05

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 45.52  E-value: 6.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138   90 YFLPSLEIISDSLGLSQDVAGATFMAAGSSAPEL---VTAFLGVfiTKGDIGISTILGSAIYN---LLGICAACGLLSNM 163
Cdd:PLN03151 161 YFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVfasIAAFVGK--DAGEVGLNSVLGGAVFVtcvVVGIVSLCVADKEV 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  164 VSTLSCWplFRDCAVYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLCFDTTISRHV----MKTCSPCCPCLARAM 239
Cdd:PLN03151 239 QIDKRCF--IRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHArrlkLDVVTPLLPVQGSIF 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  240 EERIEqqtllgwEDESQLFIRRQSRTDSGIFQEDSGYSQLSLSLH----------GLSQVSEDPP-------SVFSMPEA 302
Cdd:PLN03151 317 SPSVE-------EDESMYSPLLESDTESDVPRLQTSLPQWMWASNvaiysnhfakGSVHDEERPPwgwtdegAEVESSLF 389

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  303 DLRRIFWVLSLPIITLLALTTPDCRRKFW-KNYFVIT------------------------------------------- 338
Cdd:PLN03151 390 SCSKLFSLLEMPLTIPRRLTIPIVEEDRWsKTYAVASaslapvllaflwssqddvslqariaayfigvaigstlgflayk 469

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  339 -------------------FFMSALWISAFTYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGkGD- 398
Cdd:PLN03151 470 ytepdrpprrflipwvlggFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDg 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876138  399 --MAISNIVGSNVFDMLC-LGLPWFIKtAFTNASAPIEVNSKGLTYITISLNISILFLFLAV-HFNGWKLDRKLGVVCLV 474
Cdd:PLN03151 549 vqIAMSGCYAGPMFNTLVgLGMSMLLG-AWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVlPRNDMRPNKTLGVGLIA 627

                        490
                 ....*....|....*..
gi 81876138  475 LYLGLATLSVLYEIGII 491
Cdd:PLN03151 628 LYLIFLTFRVSTAMGFI 644
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 98-150 2.79e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.83  E-value: 2.79e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 81876138     98 ISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNL 150
Cdd:TIGR00927  959 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDI 1011
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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