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Conserved domains on  [gi|81876340|sp|Q8C3I8|]
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RecName: Full=Protein HGH1 homolog

Protein Classification

protein HGH1( domain architecture ID 10513361)

protein HGH1 is an armadillo repeat protein that binds to the dynamic central domain III of eukaryotic elongation factor 2 (eEF2) via a bipartite interface; contains both DUF383 and DUF384 domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
120-294 3.13e-79

Domain of unknown function (DUF383);


:

Pssm-ID: 461153  Cd Length: 188  Bit Score: 241.68  E-value: 3.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876340   120 VLDPQWPWAEEAAAVLANLSREPAPCAALMEKLMAAEPERLG-----LERLVNALC---TPSYNAAAPLHYLGPLLSNLS 191
Cdd:pfam04063   2 ITDPKSPLADLACMLLSNLTKSDSICKSLLELKRSSEPEDLSssglaIDQLVDLFVkgaDGGYNKHANYDYLAYVFANLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876340   192 QQAEVRAFLLDP----DRCVVQRLLPLTQYtDSSVRRGGVVGTLRNCCFEHRHHKWLLGA-QVDILPFLLLPLAGPEEFS 266
Cdd:pfam04063  82 QLPEGRKYFLTPqeydGVVPLSKLLVFTEH-DSVIRRGGVASTIKNCCFDTEAHEWLLSEeEIDILPYLLLPLAGPEEYD 160

                         170       180
                  ....*....|....*....|....*...
gi 81876340   267 EEEMDQLPVDLQYLSPDKQREPDADIRK 294
Cdd:pfam04063 161 EEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
299-353 4.22e-19

Domain of unknown function (DUF384);


:

Pssm-ID: 461154  Cd Length: 55  Bit Score: 80.19  E-value: 4.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 81876340   299 AVMLLTATAPGRKQVRDQGAYLILRELHSWEPEPDVRMACEKLIQVLIGDEPEAG 353
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWEEDEKVREACERLVQLLIRDEEEEG 55
 
Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
120-294 3.13e-79

Domain of unknown function (DUF383);


Pssm-ID: 461153  Cd Length: 188  Bit Score: 241.68  E-value: 3.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876340   120 VLDPQWPWAEEAAAVLANLSREPAPCAALMEKLMAAEPERLG-----LERLVNALC---TPSYNAAAPLHYLGPLLSNLS 191
Cdd:pfam04063   2 ITDPKSPLADLACMLLSNLTKSDSICKSLLELKRSSEPEDLSssglaIDQLVDLFVkgaDGGYNKHANYDYLAYVFANLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876340   192 QQAEVRAFLLDP----DRCVVQRLLPLTQYtDSSVRRGGVVGTLRNCCFEHRHHKWLLGA-QVDILPFLLLPLAGPEEFS 266
Cdd:pfam04063  82 QLPEGRKYFLTPqeydGVVPLSKLLVFTEH-DSVIRRGGVASTIKNCCFDTEAHEWLLSEeEIDILPYLLLPLAGPEEYD 160

                         170       180
                  ....*....|....*....|....*...
gi 81876340   267 EEEMDQLPVDLQYLSPDKQREPDADIRK 294
Cdd:pfam04063 161 EEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
299-353 4.22e-19

Domain of unknown function (DUF384);


Pssm-ID: 461154  Cd Length: 55  Bit Score: 80.19  E-value: 4.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 81876340   299 AVMLLTATAPGRKQVRDQGAYLILRELHSWEPEPDVRMACEKLIQVLIGDEPEAG 353
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWEEDEKVREACERLVQLLIRDEEEEG 55
 
Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
120-294 3.13e-79

Domain of unknown function (DUF383);


Pssm-ID: 461153  Cd Length: 188  Bit Score: 241.68  E-value: 3.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876340   120 VLDPQWPWAEEAAAVLANLSREPAPCAALMEKLMAAEPERLG-----LERLVNALC---TPSYNAAAPLHYLGPLLSNLS 191
Cdd:pfam04063   2 ITDPKSPLADLACMLLSNLTKSDSICKSLLELKRSSEPEDLSssglaIDQLVDLFVkgaDGGYNKHANYDYLAYVFANLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81876340   192 QQAEVRAFLLDP----DRCVVQRLLPLTQYtDSSVRRGGVVGTLRNCCFEHRHHKWLLGA-QVDILPFLLLPLAGPEEFS 266
Cdd:pfam04063  82 QLPEGRKYFLTPqeydGVVPLSKLLVFTEH-DSVIRRGGVASTIKNCCFDTEAHEWLLSEeEIDILPYLLLPLAGPEEYD 160

                         170       180
                  ....*....|....*....|....*...
gi 81876340   267 EEEMDQLPVDLQYLSPDKQREPDADIRK 294
Cdd:pfam04063 161 EEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
299-353 4.22e-19

Domain of unknown function (DUF384);


Pssm-ID: 461154  Cd Length: 55  Bit Score: 80.19  E-value: 4.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 81876340   299 AVMLLTATAPGRKQVRDQGAYLILRELHSWEPEPDVRMACEKLIQVLIGDEPEAG 353
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWEEDEKVREACERLVQLLIRDEEEEG 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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