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Conserved domains on  [gi|46577468|sp|Q8CBE3|]
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RecName: Full=WD repeat-containing protein 37

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-441 2.19e-45

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.54  E-value: 2.19e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 147 QLVKEYIGHRDGIWDVSVTRTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 227 RyvvqLPTPQPVADTSQQISGEDEIECSDkdepdiDGD---VSSDCPTVRV-------PLTSLKSHQGVVIAADWLVGGK 296
Cdd:COG2319 190 D----LATGKLLRTLTGHTGAVRSVAFSP------DGKllaSGSADGTVRLwdlatgkLLRTLTGHSGSVRSVAFSPDGR 259

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 297 QVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTSAV 376
Cdd:COG2319 260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46577468 377 FT-VGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSG 441
Cdd:COG2319 338 FSpDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
DivIVA super family cl34642
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 1.74e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG3599:

Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 38.30  E-value: 1.74e-03
                        10        20
                ....*....|....*....|....*...
gi 46577468  64 QIEREFENLYIENLELRREIDTLNERLA 91
Cdd:COG3599  31 EVAEDYERLIRENKELKEKLEELEEELE 58
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-441 2.19e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.54  E-value: 2.19e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 147 QLVKEYIGHRDGIWDVSVTRTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 227 RyvvqLPTPQPVADTSQQISGEDEIECSDkdepdiDGD---VSSDCPTVRV-------PLTSLKSHQGVVIAADWLVGGK 296
Cdd:COG2319 190 D----LATGKLLRTLTGHTGAVRSVAFSP------DGKllaSGSADGTVRLwdlatgkLLRTLTGHSGSVRSVAFSPDGR 259

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 297 QVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTSAV 376
Cdd:COG2319 260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46577468 377 FT-VGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSG 441
Cdd:COG2319 338 FSpDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-486 3.42e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.81  E-value: 3.42e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 148 LVKEYIGHRDGIWDVSVTRTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWr 227
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 228 yvvqlptpqpvadtsqqisgedeiecsdkdepdidgDVSSDCptvrvPLTSLKSHQGVVIAADWLVGGKQVVTASWDRTA 307
Cdd:cd00200  79 ------------------------------------DLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 308 NLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRdpSIHSVNVFQGHTDTVTSAVFT-VGDNVVSG 386
Cdd:cd00200 118 KVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR--TGKCVATLTGHTGEVNSVAFSpDGEKLLSS 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 387 SDDRTVKVWDLKnMRSPIATIRT-DSAINRINVCVGQKIIALPHDNRQVRLFDM-SGVRLARLprssrQGHRRMVCCSAW 464
Cdd:cd00200 196 SSDGTIKLWDLS-TGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLrTGECVQTL-----SGHTNSVTSLAW 269

                       330       340
                ....*....|....*....|..
gi 46577468 465 SEDhpICNLFTCGFDRQAIGWN 486
Cdd:cd00200 270 SPD--GKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-226 1.80e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.80e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 46577468    188 TGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
189-226 4.74e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.74e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 46577468   189 GKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 153-410 9.07e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.97  E-value: 9.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468  153 IGHRDGIWDVSVTRTQPIVLGTASADHTALLWSI-------ETGKCLVKYAGHVGSVNSIKFHPSEQLALTASG-DQTAH 224
Cdd:PTZ00421  72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468  225 IWryvvqlptpqpvaDTSQQISGEdeiecsdkdepdidgdvssdcptvrvpltSLKSHQGVVIAADWLVGGKQVVTASWD 304
Cdd:PTZ00421 152 VW-------------DVERGKAVE-----------------------------VIKCHSDQITSLEWNLDGSLLCTTSKD 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468  305 RTANLYDVETSELVHSLTGHDqelthccTHPTQRLVVTSSRDTtfrlwdfrdpsihsvnvfqghtdtvtsaVFTVGdnvV 384
Cdd:PTZ00421 190 KKLNIIDPRDGTIVSSVEAHA-------SAKSQRCLWAKRKDL----------------------------IITLG---C 231

                        250       260
                 ....*....|....*....|....*.
gi 46577468  385 SGSDDRTVKVWDLKNMRSPIATIRTD 410
Cdd:PTZ00421 232 SKSQQRQIMLWDTRKMASPYSTVDLD 257
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 1.74e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 38.30  E-value: 1.74e-03
                        10        20
                ....*....|....*....|....*...
gi 46577468  64 QIEREFENLYIENLELRREIDTLNERLA 91
Cdd:COG3599  31 EVAEDYERLIRENKELKEKLEELEEELE 58
DivIVA pfam05103
DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum ...
 60-91 7.09e-03

DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.


Pssm-ID: 428304 [Multi-domain]  Cd Length: 131  Bit Score: 36.78  E-value: 7.09e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 46577468    60 ELFGQIEREFENLYIENLELRREIDTLNERLA 91
Cdd:pfam05103  25 EFLDQVAEDYEALIRENAELKEKIEELEEKLA 56
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-441 2.19e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.54  E-value: 2.19e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 147 QLVKEYIGHRDGIWDVSVTRTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 227 RyvvqLPTPQPVADTSQQISGEDEIECSDkdepdiDGD---VSSDCPTVRV-------PLTSLKSHQGVVIAADWLVGGK 296
Cdd:COG2319 190 D----LATGKLLRTLTGHTGAVRSVAFSP------DGKllaSGSADGTVRLwdlatgkLLRTLTGHSGSVRSVAFSPDGR 259

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 297 QVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTSAV 376
Cdd:COG2319 260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46577468 377 FT-VGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSG 441
Cdd:COG2319 338 FSpDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-486 3.42e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.81  E-value: 3.42e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 148 LVKEYIGHRDGIWDVSVTRTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWr 227
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 228 yvvqlptpqpvadtsqqisgedeiecsdkdepdidgDVSSDCptvrvPLTSLKSHQGVVIAADWLVGGKQVVTASWDRTA 307
Cdd:cd00200  79 ------------------------------------DLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 308 NLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRdpSIHSVNVFQGHTDTVTSAVFT-VGDNVVSG 386
Cdd:cd00200 118 KVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR--TGKCVATLTGHTGEVNSVAFSpDGEKLLSS 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 387 SDDRTVKVWDLKnMRSPIATIRT-DSAINRINVCVGQKIIALPHDNRQVRLFDM-SGVRLARLprssrQGHRRMVCCSAW 464
Cdd:cd00200 196 SSDGTIKLWDLS-TGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLrTGECVQTL-----SGHTNSVTSLAW 269

                       330       340
                ....*....|....*....|..
gi 46577468 465 SEDhpICNLFTCGFDRQAIGWN 486
Cdd:cd00200 270 SPD--GKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-438 1.37e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.27  E-value: 1.37e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 128 ASTSKIVSSFKTTTSRAICQLVkeyiGHRDGIWDVSVTRTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKF 207
Cdd:cd00200  27 GSGDGTIKVWDLETGELLRTLK----GHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAF 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 208 HPSEQLALTASGDQTAHIWryvvQLPTPQPVadtsqqisgedeiecsdkdepdidgdvssdcptvrvplTSLKSHQGVVI 287
Cdd:cd00200 102 SPDGRILSSSSRDKTIKVW----DVETGKCL--------------------------------------TTLRGHTDWVN 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 288 AADWLVGGKQVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRdpSIHSVNVFQG 367
Cdd:cd00200 140 SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLRG 217

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46577468 368 HTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNmRSPIATIR-TDSAINRINVC-VGQKIIALPHDNRqVRLFD 438
Cdd:cd00200 218 HENGVNSVAFSPDGYlLASGSEDGTIRVWDLRT-GECVQTLSgHTNSVTSLAWSpDGKRLASGSADGT-IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
147-495 1.45e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 1.45e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 147 QLVKEYIGHRDGIWDVSVTRTqPIVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 227 RyvvqLPTPQPVAdtsqqisgedeiecsdkdepdidgdvssdcptvrvpltSLKSHQGVVIAADWLVGGKQVVTASWDRT 306
Cdd:COG2319 148 D----LATGKLLR--------------------------------------TLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 307 ANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTSAVFTV-GDNVVS 385
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL--LRTLTGHSGSVRSVAFSPdGRLLAS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 386 GSDDRTVKVWDLKNmRSPIATIRTDS-AINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARlprsSRQGHRRMVCCSAW 464
Cdd:COG2319 264 GSADGTVRLWDLAT-GELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAF 338

                       330       340       350
                ....*....|....*....|....*....|.
gi 46577468 465 SEDHPIcnLFTCGFDRQAIGWNINIPALLQE 495
Cdd:COG2319 339 SPDGKT--LASGSDDGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 197-495 6.62e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 6.62e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 197 GHVGSVNSIKFHPSEQLALTASGDQTAHIWRYvvqlptpqpvadtsqqisgedeiecsdkdepdidgdvssdcpTVRVPL 276
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL------------------------------------------ETGELL 44

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 277 TSLKSHQGVVIAADWLVGGKQVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRD 356
Cdd:cd00200  45 RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 357 PSIhsVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNMRsPIATIRT-DSAINRINVCVGQKIIALPHDNRQV 434
Cdd:cd00200 125 GKC--LTTLRGHTDWVNSVAFSPDGTfVASSSQDGTIKLWDLRTGK-CVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTI 201

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46577468 435 RLFDMSGVRLARLPRssrqGHRRMVCCSAWSEDHPIcnLFTCGFDRQAIGWNINIPALLQE 495
Cdd:cd00200 202 KLWDLSTGKCLGTLR----GHENGVNSVAFSPDGYL--LASGSEDGTIRVWDLRTGECVQT 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 279-494 2.82e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 2.82e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 279 LKSHQGVVIAADWLVGGKQVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPs 358
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 359 iHSVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNmRSPIATIRT-DSAINRINVCVGQKIIALPHDNRQVRL 436
Cdd:cd00200  84 -ECVRTLTGHTSYVSSVAFSPDGRiLSSSSRDKTIKVWDVET-GKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 46577468 437 FDM-SGVRLARLPrssrqGHRRMVCCSAWSEDHPicNLFTCGFDRQAIGWNINIPALLQ 494
Cdd:cd00200 162 WDLrTGKCVATLT-----GHTGEVNSVAFSPDGE--KLLSSSSDGTIKLWDLSTGKCLG 213
WD40 COG2319
WD40 repeat [General function prediction only];
260-488 2.70e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 2.70e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 260 DIDGDVSSDCPTVRVPLTSLKSHQGVVIAADWLVGGKQVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRL 339
Cdd:COG2319  13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 340 VVTSSRDTTFRLWDFRDPsiHSVNVFQGHTDTVTSAVFT-VGDNVVSGSDDRTVKVWDLKNmRSPIATIRT-DSAINRIN 417
Cdd:COG2319  93 LASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLLRTLTGhSGAVTSVA 169

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46577468 418 VCVGQKIIALPHDNRQVRLFDM-SGVRLARLprssrQGHRRMVCCSAWSEDHPIcnLFTCGFDRQAIGWNIN 488
Cdd:COG2319 170 FSPDGKLLASGSDDGTVRLWDLaTGKLLRTL-----TGHTGAVRSVAFSPDGKL--LASGSADGTVRLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
295-495 2.74e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 2.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 295 GKQVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTS 374
Cdd:COG2319   6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAL--LATLLGHTAAVLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 375 AVFTV-GDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDM-SGVRLARLPrssr 452
Cdd:COG2319  84 VAFSPdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLT---- 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 46577468 453 qGHRRMVCCSAWSEDHPIcnLFTCGFDRQAIGWNINIPALLQE 495
Cdd:COG2319 160 -GHSGAVTSVAFSPDGKL--LASGSDDGTVRLWDLATGKLLRT 199
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-226 1.80e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.80e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 46577468    188 TGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
189-226 4.74e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.74e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 46577468   189 GKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 314-353 5.74e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.74e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 46577468    314 TSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWD 353
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
362-396 7.37e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 46577468   362 VNVFQGHTDTVTSAVFTV-GDNVVSGSDDRTVKVWD 396
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPdGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 153-410 9.07e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.97  E-value: 9.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468  153 IGHRDGIWDVSVTRTQPIVLGTASADHTALLWSI-------ETGKCLVKYAGHVGSVNSIKFHPSEQLALTASG-DQTAH 224
Cdd:PTZ00421  72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468  225 IWryvvqlptpqpvaDTSQQISGEdeiecsdkdepdidgdvssdcptvrvpltSLKSHQGVVIAADWLVGGKQVVTASWD 304
Cdd:PTZ00421 152 VW-------------DVERGKAVE-----------------------------VIKCHSDQITSLEWNLDGSLLCTTSKD 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468  305 RTANLYDVETSELVHSLTGHDqelthccTHPTQRLVVTSSRDTtfrlwdfrdpsihsvnvfqghtdtvtsaVFTVGdnvV 384
Cdd:PTZ00421 190 KKLNIIDPRDGTIVSSVEAHA-------SAKSQRCLWAKRKDL----------------------------IITLG---C 231

                        250       260
                 ....*....|....*....|....*.
gi 46577468  385 SGSDDRTVKVWDLKNMRSPIATIRTD 410
Cdd:PTZ00421 232 SKSQQRQIMLWDTRKMASPYSTVDLD 257
WD40 pfam00400
WD domain, G-beta repeat;
315-353 1.17e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 46577468   315 SELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWD 353
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 358-396 1.85e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.85e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 46577468    358 SIHSVNVFQGHTDTVTSAVFT-VGDNVVSGSDDRTVKVWD 396
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
335-495 1.08e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 335 PTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFqGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAIN 414
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLG-LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468 415 RINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPrssrQGHRRMVCCSAWSEDHPIcnLFTCGFDRQAIGWNINIPALLQ 494
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTL----TGHTGAVRSVAFSPDGKT--LASGSADGTVRLWDLATGKLLR 156


                .
gi 46577468 495 E 495
Cdd:COG2319 157 T 157
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 331-418 1.17e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46577468  331 CCTH---PTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFqGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATI 407
Cdd:PLN00181 621 CCVQfpsESGRSLAFGSADHKVYYYDLRNPKLPLCTMI-GHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINET 699

                         90
                 ....*....|.
gi 46577468  408 RTDSAINRINV 418
Cdd:PLN00181 700 PLHSFMGHTNV 710
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 1.74e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 38.30  E-value: 1.74e-03
                        10        20
                ....*....|....*....|....*...
gi 46577468  64 QIEREFENLYIENLELRREIDTLNERLA 91
Cdd:COG3599  31 EVAEDYERLIRENKELKEKLEELEEELE 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 275-311 5.03e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 5.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 46577468    275 PLTSLKSHQGVVIAADWLVGGKQVVTASWDRTANLYD 311
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
DivIVA pfam05103
DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum ...
 60-91 7.09e-03

DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.


Pssm-ID: 428304 [Multi-domain]  Cd Length: 131  Bit Score: 36.78  E-value: 7.09e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 46577468    60 ELFGQIEREFENLYIENLELRREIDTLNERLA 91
Cdd:pfam05103  25 EFLDQVAEDYEALIRENAELKEKIEELEEKLA 56
WD40 pfam00400
WD domain, G-beta repeat;
275-311 9.69e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 9.69e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 46577468   275 PLTSLKSHQGVVIAADWLVGGKQVVTASWDRTANLYD 311
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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