|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
79-502 |
0e+00 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 744.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 79 AIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANR 158
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 159 VFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLA 238
Cdd:cd17382 81 VFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 239 GVLVQYIGWSSVFYIYGMFGIIWYMFWLLQayecpaahptisneektyietsigeganvvslskfstpwkrfftSLPVYA 318
Cdd:cd17382 161 GILVQYVGWSSPFYVYGVFGIIWYMFWMLV--------------------------------------------SMPVYA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 319 IIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGFG 398
Cdd:cd17382 197 IIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 399 MEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTRE 478
Cdd:cd17382 277 MEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTRE 356
|
410 420
....*....|....*....|....
gi 74723817 479 EWQNVFLIAALVHYSGVIFYGVFA 502
Cdd:cd17382 357 EWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
79-502 |
3.92e-171 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 490.98 E-value: 3.92e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 79 AIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGK-------PEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFIS 151
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNtstdkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 152 NKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGA 231
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 232 VVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWllqayecpaahptisneektyietsigeganvvslskfstpwkrFF 311
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW--------------------------------------------FF 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 312 TSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKI 391
Cdd:cd17318 197 LVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 392 MNCGGFGMEATLLLVVGF-SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGA 470
Cdd:cd17318 277 FTSIGFLGPGVFLIALGYlGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGA 356
|
410 420 430
....*....|....*....|....*....|...
gi 74723817 471 MTRHK-TREEWQNVFLIAALVHYSGVIFYGVFA 502
Cdd:cd17318 357 IVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
78-502 |
6.08e-125 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 373.35 E-value: 6.08e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 78 IAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGK-----PEIQTAQ----------FNWDPETVGLIHGSFFWGYIM 142
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNssnacPEHSSSPsvehnetgkkYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 143 TQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATT 222
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 223 SFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWllqayecpaahptisneektyietsigeganvvslsk 302
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLW------------------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 303 fstpwkrFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQI 382
Cdd:cd17381 204 -------IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQN 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 383 LTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGV-AISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSG 461
Cdd:cd17381 277 FSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSlAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPG 356
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 74723817 462 MVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFA 502
Cdd:cd17381 357 MVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
84-502 |
2.30e-99 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 306.40 E-value: 2.30e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 84 LGFCISFGIRCNLGVAIVEMvnnstvyvdgkpeiqTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAA 163
Cdd:cd17380 6 LATCICYADRVNMPIAIVPM---------------AKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 164 IFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQ 243
Cdd:cd17380 71 VALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 244 YIGWSSVFYIYGMFGIIWYMFWllqayecpaahptisneektyietsigeganvvslskfstpwkrFFTSLPVYAIIVAN 323
Cdd:cd17380 151 YYGWPSVFYFFGLLGLLWALVW--------------------------------------------LIYLPPVWAIIVAH 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 324 FCRSWTFYLLLISQPAYFEEVFGfAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQIlTTTAVRKIMNCGGFGMEATL 403
Cdd:cd17380 187 FCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALF 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 404 LLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGA-MTRHKTreeWQN 482
Cdd:cd17380 265 LLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYiLEATGS---WSL 341
|
410 420
....*....|....*....|
gi 74723817 483 VFLIAALVHYSGVIFYGVFA 502
Cdd:cd17380 342 VFVLAAVVNLVGAVVFLLFG 361
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
75-513 |
1.54e-96 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 302.43 E-value: 1.54e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 75 RYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKP-------EIQTAQFNWDPETVGLIHGSFFWGYIMTQIPG 147
Cdd:TIGR00894 17 RLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLsaeneldNIKNPNFKWSGALQGLILSSHFYGQIIIQIPV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 148 GFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGS 227
Cdd:TIGR00894 97 GYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 228 YAGAVVAMPLAGVLVQY-IGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGanvVSLSKFSTP 306
Cdd:TIGR00894 177 QLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQ---KGSTRQSLP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 307 WKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTT 386
Cdd:TIGR00894 254 IKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSLT 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 387 AVRKIMN-CGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCP 465
Cdd:TIGR00894 334 AARKIFNgIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIAS 413
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 74723817 466 LIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPE 513
Cdd:TIGR00894 414 TLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEE 461
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
73-502 |
4.13e-47 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 168.90 E-value: 4.13e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 73 PKRYIIAIMSGLGFCISFGIRCNLGVAIVEMvnnstvyvdgkpeiqTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISN 152
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPL---------------QADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 153 KFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMcvRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAV 232
Cdd:COG2271 71 RFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLL--RFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 233 VAMPLAGVLVQYIGWSSVFYIYGMFGIIW--YMFWLLqayecpaahptisneektyietsigeganvvslskfstpwkrf 310
Cdd:COG2271 149 LAPPLLGWLLAAFGWRAAFLILGLPGLLLalLRFWLL------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 311 ftslpvyaiIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRqiltttavRK 390
Cdd:COG2271 186 ---------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--------RK 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 391 IMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAP-RYASILMGISNGVGTLSGMVCPLIVG 469
Cdd:COG2271 249 LVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVG 328
|
410 420 430
....*....|....*....|....*....|...
gi 74723817 470 AMTRHKTreeWQNVFLIAALVHYSGVIFYGVFA 502
Cdd:COG2271 329 YLLDATG---YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
75-471 |
1.13e-46 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 167.75 E-value: 1.13e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 75 RYIIAIMSGLGFCISFGIRCNLGVAIVEMVnnstvyvdgkpeiqtAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKF 154
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIM---------------KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRF 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 155 AANRVFGAAIFLTSTLNMFIpSAARVHYGCVMCvRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVA 234
Cdd:cd17319 66 GARKVLAVSMLLWSLFTALT-GFATSLTSLYVL-RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 235 MPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWllqayecpaahptisneektyietsigeganvvslskfstpWKRFFTsl 314
Cdd:cd17319 144 PPLSGWLLLLFGWRWAFIIEGLLGLLLAVLW-----------------------------------------WFYLRQ-- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 315 pVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQiltttavRKIMNC 394
Cdd:cd17319 181 -VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA-------RRLVII 252
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74723817 395 GGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPR-YASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:cd17319 253 IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYL 330
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
115-463 |
2.37e-35 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 136.01 E-value: 2.37e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 115 PEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVmcVRILQGL 194
Cdd:pfam07690 20 PLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV--LRVLQGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 195 VEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYEcPA 274
Cdd:pfam07690 98 GAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPP-PE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 275 AHPTISNEEKTYIetsigeganvvslskFSTPWKRFFTSLPVYAIIVAnFCRSWTFYLLLISQPAYfEEVFGFAISKVGL 354
Cdd:pfam07690 177 SKRPKPAEEARLS---------------LIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLY-QEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 355 LSAVPHMVMTIVVPIGGQLADYLRSRQILtttavrkIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGF 434
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRL-------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|
gi 74723817 435 NVNHLDIAP-RYASILMGISNGVGTLSGMV 463
Cdd:pfam07690 313 NALVSDLAPkEERGTASGLYNTAGSLGGAL 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
121-498 |
7.00e-32 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 127.16 E-value: 7.00e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 121 QFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAarVHYGCVMCVRILQGLVEGVTY 200
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA--PSFWLLLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 201 PACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYI--GWSSVFYIYGMFGIIWYMFWLLqayeCPAAHPT 278
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLL----VVPDPPE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 279 ISNEEKTyietsigeganVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAV 358
Cdd:cd06174 179 SARAKNE-----------EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 359 PHMVMTIVVPIGGQLADYLRSRqiltttavRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNH 438
Cdd:cd06174 248 FGLAGALGSLLLGLLSDRLIGR--------KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 439 LDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTReeWQNVFLIAALVHYSGVIFY 498
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
119-461 |
5.69e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 118.15 E-value: 5.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 119 TAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAArvHYGCVMCVRILQGLVEGV 198
Cdd:COG2814 37 AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 199 TYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIwymFWLLQAYECPAAHPT 278
Cdd:COG2814 115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALL---ALLLLLRLLPESRPA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 279 ISneektyietsigeganvvslSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAV 358
Cdd:COG2814 192 AR--------------------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 359 PHMVMTIVVPIGGQLADYLRSRQILTttavrkimncGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNH 438
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRLLL----------IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV 321
|
330 340
....*....|....*....|....
gi 74723817 439 LDIAP-RYASILMGISNGVGTLSG 461
Cdd:COG2814 322 AELAPpEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
73-490 |
7.44e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 112.67 E-value: 7.44e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 73 PKRYIIAIMSGLGFCISFGIRCNLGVAIVEMvnnstvyvdgkpeiqTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISN 152
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL---------------AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 153 KFAANRVFGAAIFLTSTLNMFIPSAarVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAV 232
Cdd:COG2223 66 RFGPRRVLLIGLLLLGIGLLLLALA--VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAA 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 233 VAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPaahptisneektyietsigEGANVVSLSKFSTpWKRFFT 312
Cdd:COG2223 144 VAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPP-------------------AGAAAAAKASLRD-QLEALR 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 313 SLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVrkim 392
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA---- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 393 ncggfGMEATLLLVVGFSHTKGVAI-SFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:COG2223 280 -----LMALGLLLLALALGSLWLFLvLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
410
....*....|....*....
gi 74723817 472 trHKTREEWQNVFLIAALV 490
Cdd:COG2223 355 --LDATGSYTAAFLVFAVL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
129-490 |
7.08e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.81 E-value: 7.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 129 VGLIHGSFFWGYIMTQIPGGFISNKFAANR--VFGAAIFLTSTLnMFIPSAarvHYGCVMCVRILQGLVEGVTYPACHGM 206
Cdd:cd17325 33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRllLLGLLLLAVSTL-LFAFAT---SYWQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 207 WSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGII--WYMFWLLqayecpaaHPTISNEEK 284
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLalVLALLLL--------PEPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 285 tyietsigegaNVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMT 364
Cdd:cd17325 181 -----------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 365 IVVPIGGQLADYLRSRQILTttavrkimncggFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHL--DIA 442
Cdd:cd17325 250 LSQPPAGKLSDRIGRKPLIL------------IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALlaDIV 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 74723817 443 PRYA-SILMGISNGVGTLSGMVCPLIVGAMTrhkTREEWQNVFLIAALV 490
Cdd:cd17325 318 PPEGrGTAMGLFNTAFSLGMVLGPLLGGFLY---DAFGFATPFLAAAAL 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
115-502 |
1.07e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 79.15 E-value: 1.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 115 PEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTS---TLNMFIPSaarvhYGCVMCVRIL 191
Cdd:cd17473 23 PAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGiggVAGLFLDS-----LYALLASRAL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 192 QGLVEGVTYPACHGMWSKWAPPLERSRL-----ATTSFcgsyaGAVVAMPLAGVLVQyIGWSSVFYIYGMFGIIWYMFWL 266
Cdd:cd17473 98 LGIGVAGIMTLATALIGDYFEGEERAKMlglqsAAMSL-----GGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 267 LqayecpaahptISNEEKTYIETSIGEGANVVSLskfstPWKRfftslpVYAIIVANFCRSWTFYLLLISQPAYFEEVFG 346
Cdd:cd17473 172 F-----------LPEPARKSKSAASPGAATAAAL-----PWKR------VLPIYFLAFLAMLLFYVIPIQLPFLLQERGG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 347 FAISKVGLLSAvphmVMTIVVPIGGQLADYLRSRqILTTTAVrkimnCGGFGMEATLLLVVGFSHTKGVAISFLVLaVGF 426
Cdd:cd17473 230 GSAALIGLALA----IASLAGAIGALLFGRLKRR-LGKRRLL-----AIGFALMALGFLLLALASGLWVVLLGAIL-AGL 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74723817 427 sGFAISGFNVNH--LDIAPRYAS-ILMGISNGVGTLSGMVCPLIVGAMTRHKTREewQNVFLIAALVHYSGVIFYGVFA 502
Cdd:cd17473 299 -GFGLLLPTLNSwaMSLVPPELRgRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGL--SGAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
120-471 |
1.06e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 73.16 E-value: 1.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 120 AQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFipSAARVHYGCVMCVRILQGLVEGVT 199
Cdd:TIGR00895 45 AEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLILRFLAGLGLGGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 200 YPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGII---WYMFWLLQAYE----- 271
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLlllLLMRFLPESIDflvsk 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 272 CPAAHPTISNEEKTYIETSIGEGanVVSLSKFSTPWKRFF-------TSLPVYAIIVANFCRSWTFYLLLISQPaYFEEV 344
Cdd:TIGR00895 203 RPETVRRIVNAIAPQMQAEAQSA--LPEQKSTQGTKRSVFkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVE 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 345 FGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILtttavrkimncGGFGMEATLLLVVGFSHTKGVAISFLVLAV 424
Cdd:TIGR00895 280 LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA-----------LLLLLGAVFAVLVGSTLFSPTLLLLLGAIA 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 74723817 425 GFsgFAISGFNVNHLDIAPRYASIL----MGISNGVGTLSGMVCPLIVGAM 471
Cdd:TIGR00895 349 GF--FVNGGQSGLYALMALFYPTAIratgVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
76-467 |
4.15e-13 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 71.51 E-value: 4.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 76 YIIAIMSGLGFCISFGIRCNLGVAivemvnnstvYVDGKPE---IQTAQFNWdpetvglIHGSFFWGYIMTQIPGGFISN 152
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNA----------AVMGMKEdlkLVGNQYNW-------GNTVFYVGYIIFELPGNLLLQ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 153 KFAANRVFGAAIFLTSTLNMFipSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAV 232
Cdd:cd17327 67 RFPPSKWLSVFIVLWGLLTLL--TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 233 VAMPLA-GvlVQYI-------GWSSVFYIYGMFGIIW--YMFWLLQAYECPAahPTISNEEKTYIETSIGEGANVVSLSK 302
Cdd:cd17327 145 FGGLLAyG--VFKIlgvgglaGWRWLFIIEGLITIIIglVIFFWLPDNPSKA--WFLTEEEKELAVERLRANQTGKGDQK 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 303 FS-TPWKRFFTSLPVYAIIVANFCrSW-------TFYLLLISQpayfeevFGFAISKVGLLSAVPHMVMTIVVPIGGQLA 374
Cdd:cd17327 221 FKwKQIKEAFKDPRTWLLFLFFFC-SQitnngisNFLPLILKS-------LGFYSLQTNLLSVPIGALGAVSLLIAALLS 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 375 DYLRSRQILTTtavrkIMNCggFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNhlDIAPRYAS--ILMGI 452
Cdd:cd17327 293 DRFKKRGLFAI-----FACV--LALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWIS--SNCAGYTKraTVLAI 363
|
410
....*....|....*
gi 74723817 453 SNGVGTLSGMVCPLI 467
Cdd:cd17327 364 MLIFYNVGNIVAPQI 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
115-489 |
1.19e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 69.50 E-value: 1.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 115 PEIqTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFipSAARVHYGCVMCVRILQGL 194
Cdd:cd17324 23 PDI-ARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL--AALAPSFALLLLARALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 195 VEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGII--WYMFWLLqayec 272
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLaaLLLWRLL----- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 273 paahPTISNEEKtyieTSIGEGANVVSLSKFSTPWKRFFTslpvYAIIVANFCRSWTfYLllisqPAYFEEVFGFAISKV 352
Cdd:cd17324 175 ----PSLPPKKP----GSLGLLSSLLLLLRNPRLRLAYLI----TFLLFGGFFALYT-YL-----APFLTDVPGFSSSAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 353 GLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTtavrkimncGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFsGFAIS 432
Cdd:cd17324 237 IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA---------LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF-FAAHS 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 74723817 433 GFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHktrEEWQNVFLIAAL 489
Cdd:cd17324 307 ALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDH---GGWAGVGWVGAA 360
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
117-471 |
2.01e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 68.78 E-value: 2.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 117 IQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTST---LNMFIPSaarvhYGCVMCVRILQG 193
Cdd:cd17316 26 AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLatlLIGLLPT-----PILLLVLRFLQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 194 LVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLV----QYIGWSSVFYIYGMFGIIwyMFWLlqa 269
Cdd:cd17316 101 IGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRILFLIGALPALL--ALLL--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 270 yecpaahptisneektyietsigeganvvslskfstpWKRFFtslpvyAIIVANFCRSWTFYLLLISQPAYFEEVFGFAI 349
Cdd:cd17316 176 -------------------------------------RRRTL------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 350 SKVGLLSAVPHMVMTIVVPIGGQLADYLRsrqiltttavRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVgFSGF 429
Cdd:cd17316 213 ATSSLYLLLISLGALVGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI-LSFF 281
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 74723817 430 AISGFNVNHLDIA----PRYASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:cd17316 282 VGGVWGALYAYLAelfpTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
96-374 |
2.36e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 64.83 E-value: 2.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 96 LGVAIVEMvnNSTVYVDGKPEIQtAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVF--GAAIF-LTSTLNM 172
Cdd:COG0477 21 LGTFLEGL--DFTIVNVALPSIA-ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLliGLLLFgLASLLCG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 173 FIPSAArvhygCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFY 252
Cdd:COG0477 98 LAPSPE-----LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 253 IYGMFGIIwymfWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYL 332
Cdd:COG0477 173 INAPLGLL----ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 74723817 333 LLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLA 374
Cdd:COG0477 249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLL 290
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
115-469 |
7.94e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 63.93 E-value: 7.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 115 PEIQtAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIpsAARVHYGCVMCVRILQGL 194
Cdd:TIGR00881 19 PYLV-EEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFF--GFSTSLWVMAALWALNGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 195 VEGVTYPACHGMWSKWAPPLERSRLATTSFCGS-YAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECP 273
Cdd:TIGR00881 96 FQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHnVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 274 AAhPTISNEEKTYIETSIGEGANVvslSKFSTPWKRFFTS-LPVYAIIVANFCRSWTFYLLLISQ---PAYFEEVFGFAI 349
Cdd:TIGR00881 176 QS-CGLPPAEEMPNEEPDGDAEKK---EEELTKKQIFLQYvLLNKVLWYISLGYVFVYVVRTGILdwsPLYLTQEKGFSK 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 350 SKVGLLSAVPHMVMTIVVPIGGQLADYLrsrqiltttAVRKIMNCGGFGMEATLLLVVGFSHTKG---VAISFLVLAVGF 426
Cdd:TIGR00881 252 EKASWAFTLYELGGLVGTLLAGWLSDKL---------FNGRRGPLAVFFMALIIVSLLVYWLNPAanpLMDLICLFALGF 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 74723817 427 SGFA-ISGFNVNHLDIAPRYASILM-GISNGVGTLSGMVCPLIVG 469
Cdd:TIGR00881 323 LVYGpQMLIGVIASELAPKKAAGTAaGFVGFFAYLGGILAGLPLG 367
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
215-471 |
1.43e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.77 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 215 ERSRLATTSFCGSYAGAVVAMPLAGVLVQYI------GWSSVFYIYGMFGIIWYMFWLLQAYEcpaaHPTISNEEKTYIE 288
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKE----RPVPEEEKVSLKE 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 289 TsigeganvvslskfstpWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVP 368
Cdd:COG2211 220 S-----------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAP 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 369 IGGQLADYLRSRQILtttavrkimnCGGFGMEATLLLVVGFSHTKGVAISFLVLAVgfSGFAISGFNVNHL----DIAP- 443
Cdd:COG2211 283 LWPRLAKRFGKKKAF----------IIGLLLAALGLLLLFFLGPGNLWLLLVLAAL--AGIGLGAILVLPWamlaDVVDy 350
|
250 260 270
....*....|....*....|....*....|....*
gi 74723817 444 -------RYASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:COG2211 351 dewktgrRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
115-503 |
6.11e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.41 E-value: 6.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 115 PEIQTAqFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTStLNMFIPSAARvHYGCVMCVRILQGL 194
Cdd:COG0738 32 PALKDA-FGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA-LGLLLFALAP-SYPLLLLALFLLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 195 VEGVTYPACHGMWSKWAPPLERSRLATTSFCGSyAGAVVAMPLAGVLVQY---IGWSSVFYIYGMFGIIWYMFWLLQAYe 271
Cdd:COG0738 109 GLGLLDVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKL- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 272 cpaahPTISNEEktyietSIGEGANVVSLSKFSTPwkrfftslPVYAIIVANFC--------RSWTfylllisqPAYFEE 343
Cdd:COG0738 187 -----PEIEEEE------EEAAGSAASLKSLLKNP--------RLLLGGLAIFLyvgaegaiGDWL--------PLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 344 VFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVrkimncggfgMEATLLLVVGFSHTKGVAISFLVLA 423
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL----------LAAVGLLLALLAPGPWLALIGLALV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 424 vgfsGFAISGF--NVNHL--DIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTreeWQNVFLIAALVhYSGVIFYG 499
Cdd:COG0738 310 ----GLGLSLMfpTIFSLalDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG---LRAAFLVPLVC-YLLILLLA 381
|
....
gi 74723817 500 VFAS 503
Cdd:COG0738 382 LALK 385
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
115-498 |
3.74e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 58.74 E-value: 3.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 115 PEIQtAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRV----------FGAAIFLTSTLNMFIPSaarvhygc 184
Cdd:cd17474 23 PAIA-EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVllpglllfgiGGLLCGLSDSFALLLAG-------- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 185 vmcvRILQGLVEGVTYPACHGMWSKWAPPLERSR----LATTSFCGsyagaVVAMPLAGVLVQYIGWSSVFYIYGMFGII 260
Cdd:cd17474 94 ----RALQGIGAAGLGPLALTLIGDLFEGGERAKamglYEAALGLG-----IAVGPLLGGLLAAISWRYPFFLLAALIPV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 261 --WYMFWLLqayecpaaHPTISNEEKTYIETSIGeganvvslskfstpWKRFFTSLPVYAIIVANFCRSWTFYLLLISQP 338
Cdd:cd17474 165 afLAILFLL--------PEPKEKAKSSSATKLRD--------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 339 AYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGqladYLRSRQILTttavRKIMnCGGFGMEATLLLVVGFSHTKGVAIS 418
Cdd:cd17474 223 FLLELLYGISPIIIGLLFAGWSVLLALGSLFVG----RLLKKRFGA----RRIL-VIGLLLYALSLLLLGFVPSLALLLI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 419 FLVLAVGFSGFAISGFNVNHLDIAPRYA-SILMGISNGVGTLSGMVCPLIVGAMTRHKTreeWQNVFLIAALVHYSGVIF 497
Cdd:cd17474 294 AIVLFGLGLGLNLPLLTTLVTELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLEIFG---LSAPFLVGAAIALAAAVL 370
|
.
gi 74723817 498 Y 498
Cdd:cd17474 371 L 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
114-497 |
1.23e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 57.28 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 114 KPEIQTAQFNwDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIpsAARVHYGCVMCVRILQG 193
Cdd:cd17312 26 KPPIVEEIGL-SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM--GFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 194 LVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGM----FGIIwyMFWLLqa 269
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIvglvVAII--LFFFL-- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 270 yecpaahptiSNEEKTYIETSIGeganvvslskfstpwkRFFTSLPVYAIIvanfcrSWTfylllisqPAYFEEVFGFAI 349
Cdd:cd17312 179 ----------RDSPPYVWVLSLA----------------YAFVYIVRYACL------DWG--------PLYLYEVKGYSL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 350 SKVGLLSAVPHMVMTIVVPIGGQLADYL-RSRQiltttavRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSG 428
Cdd:cd17312 219 IDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRR-------APIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVG 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74723817 429 FAISGFNVNHLDIAPRY--ASILMGISNGVGTLSGMVCPLIVGAMTRHKTreeWQNVFLIAALVHYSGVIF 497
Cdd:cd17312 292 GPINLIGGAAAQDIGRKeaAGTATGFVGLFGYLGASLAGLPLGYIIDHYG---WSTVFYFLISAALLSVLL 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
115-471 |
1.80e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.80 E-value: 1.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 115 PEIQtAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVF--GAAIF-LTSTLNMFIPSAArvhygCVMCVRIL 191
Cdd:cd17321 20 PTIA-RDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFliGLALFgLASLLCALAPSLA-----FLIAARAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 192 QGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIwyMFWLLqaye 271
Cdd:cd17321 94 QGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV--ALLLA---- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 272 cpaahptisneektyietsigeganvvslskfstpwKRFFTSLpvyaiiVANFCRSWTFYLLLISQPAYFEEVFGFAISK 351
Cdd:cd17321 168 ------------------------------------RTFSGAV------LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 352 VGLLSaVPHMVMTIVV-PIGGQLADYLRSRQILTTTAVrkimnCGGFGMeATLLLVVGFSHTKGVAISFLVLAVGFsGFA 430
Cdd:cd17321 206 AGLAL-LPLALAMLVAaPLAGRLADRFGPRLVLVAGLL-----LTAVGL-LLLALLGADSSVWLLLPGLVLLGLGL-GLF 277
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 74723817 431 ISGFNVNHLDIAPR-YASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:cd17321 278 ATPLTNAALSSVPKeKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
319-490 |
3.31e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.50 E-value: 3.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 319 IIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLrsrqiltttAVRKIMNCGGFG 398
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---------GRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 399 MEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTrhkTRE 478
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA---SLF 148
|
170
....*....|..
gi 74723817 479 EWQNVFLIAALV 490
Cdd:pfam07690 149 GWRAAFLILAIL 160
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
115-431 |
1.93e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 53.35 E-value: 1.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 115 PEIQTAqFNWDPETVGLIHGSFFWGYIMTqIP-GGFISNKFAANRVFGAAIF---LTSTLNMFIPSAArvhygcVMCV-R 189
Cdd:cd17503 20 PTIMGD-LGASLDTVQWVITSYLLALAIM-IPlSGWLADRFGTRRLFLTALAlftLGSLLCGLAPNLA------SLIIfR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 190 ILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIwyMFWLlqa 269
Cdd:cd17503 92 ILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGIL--ALLL--- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 270 yecpaahptisneektyietsigegANVVSLSKFstpwKRFFTSLPVYAIIVANFCRSWTFYLLlisqPAYFEEVFGFAI 349
Cdd:cd17503 167 -------------------------APLLDLRLF----KDRNFTLGLLLSFLLGLGLFGAMFLL----PLYLQNVLGYSA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 350 SKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTttavrkimncGGFGMEA-TLLLVVGFSHTKGVAISFLVLAVGFSG 428
Cdd:cd17503 214 FESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL----------AGLLLLAlGTLLLAFLTPDTSLWLIILPLFIRGLG 283
|
...
gi 74723817 429 FAI 431
Cdd:cd17503 284 MGL 286
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
115-471 |
3.51e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.57 E-value: 3.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 115 PEIQtAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAA---IFLTSTLNMFIPSAARVHYGCVMCvril 191
Cdd:COG2807 42 PEIR-ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAlllLAAGLLLRSLAPSVALLLAGTALI---- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 192 qGLVEGVTYPACHGMWSKWAPplERSRLATTSF-CGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAY 270
Cdd:COG2807 117 -GAGIAVGNVLLPGLIKRWFP--DRVGLMTGLYtAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 271 ECPAAHPTisneektyietsigeganvvslSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFAIS 350
Cdd:COG2807 194 RRPAAAAA----------------------APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 351 KVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVrkIMNCGGFgmeatLLLVVGFSHTKGVAISFLVLAVGfSGFA 430
Cdd:COG2807 251 TAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG--LLGLAGL-----LGLLLAPGSLPWLWAVLLGLGQG-GLFP 322
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 74723817 431 ISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:COG2807 323 LALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGAL 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
306-490 |
3.79e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.28 E-value: 3.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 306 PWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTt 385
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 386 tavrkimncGGFGMEATLLLVVGFSHTkgvaISFLVLAVGFSGFAISGFNVNHLDIAPRYAS-----ILMGISNGVGTLS 460
Cdd:COG2814 80 ---------LGLLLFALGSLLCALAPS----LWLLLAARFLQGLGAGALFPAALALIADLVPperrgRALGLLGAGLGLG 146
|
170 180 190
....*....|....*....|....*....|
gi 74723817 461 GMVCPLIVGAMTRHktrEEWQNVFLIAALV 490
Cdd:COG2814 147 PALGPLLGGLLADL---FGWRWVFLVNAVL 173
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
78-453 |
9.07e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.42 E-value: 9.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 78 IAIMSGLGFCISFGircnlgvaivemvnnSTVYVDGKPEIQTaQFNWDPETVGLIHGSFFWGY-IMTQIPGGFiSNKFAA 156
Cdd:cd17323 1 VFIISFLTFVVTFG---------------SSIYSPALPQIAE-DFHVSEEVANLGVSLFVLGFgLGPLIWAPL-SELYGR 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 157 NRVFGAAIFLTSTLNmfIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRlATTSFC-GSYAGAVVAM 235
Cdd:cd17323 64 RPVYLVSLFIFVIFQ--IGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGK-AMGVYSlGPLLGPALGP 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 236 PLAGVLVQYIGWSSVFYIYGMF-GIIWYMFWLLqayeCPaahptisneektyietsigegaNVVSLSkfstpwkrFFTSL 314
Cdd:cd17323 141 IIGGFITQSLGWRWIFWFLAIIsGFCLILIFLF----LP----------------------IVLLLG--------LYVGL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 315 pVYAIIvanfcrswtfYLLLISQPAYFEEVFGFAISKVGlLSAVPHMV-MTIVVPIGGQLADYLRSRqiltttavRKIMN 393
Cdd:cd17323 187 -VYAIL----------YLFLTAFPYVFGEVYGFSPGEVG-LMYLPIGIgALIGSIIGGRLSDYYYRR--------LKKKN 246
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 394 CGGFGMEATLLLVVgfshtkgvaISFLVLAVGFSGFAISGFNVNHLdIAPRYASILMGIS 453
Cdd:cd17323 247 GGKPEPEARLPPAF---------IGAFLFPIGLFIFGWTIYPHIHW-IVPIIGSAFFGFG 296
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
189-426 |
1.30e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 51.14 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 189 RILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYI--------GWSSVFYIYGMFGII 260
Cdd:cd17367 108 RLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLgedqmaawGWRIPFLLGGVLAVV 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 261 wyMFWLLQAYEcpaahptisnEEKTYIETSIGEGANVVSLSKFSTPWKrffTSLPVYAIIVANfcrSWTFYLLLISQPAY 340
Cdd:cd17367 188 --VLWLRRGLE----------ETESFEAIAESNEASAGTLRELRRHPR---ELLLVVGLTAGG---TLAFYTWTTYLQKF 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 341 FEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVrkimncggFGMEATLLLVVGFSHTKGVAISFL 420
Cdd:cd17367 250 LVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGI--------GGTLATVPLLSALDHTDSPYTAFA 321
|
....*.
gi 74723817 421 VLAVGF 426
Cdd:cd17367 322 LVLVGL 327
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
125-471 |
4.99e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 48.74 E-value: 4.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 125 DPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRV-------FGAAIFLT---STLNMFipsaarvhygcvMCVRILQGL 194
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVllvsvalFGLFTLLTafaQSVLQL------------ALLRFLTGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 195 VEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIwymfwLLqayecPA 274
Cdd:cd17365 100 GLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI-----LL-----PL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 275 AHPTIsneektyietsigeganvvslskfsTPWKRFFTSLPVyaiivanfcrswtFYLLLISQPAYFEEVfGFAISKVGL 354
Cdd:cd17365 170 LRGTL-------------------------LLWVTFFMGLLL-------------VYLLNSWLPKLMVEA-GYSLSQALT 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 355 LSAVPHMVMTIVVPIGGQLADYLRSRQILTttavrkimncGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAI-SG 433
Cdd:cd17365 211 ITLLLNIGGVIGSLLLGWLADRFGPKRVLA----------LFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAqVG 280
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 74723817 434 FNVnhldIAPRY--ASIL---MGISNGVGTLSGMVCPLIVGAM 471
Cdd:cd17365 281 LYA----LAARFypTEVRatgVGWALGVGRLGAILGPLLGGLL 319
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
189-471 |
5.05e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 49.11 E-value: 5.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 189 RILQGLVEGVTyPACHGMWSKWAPPlERSRLATTSFCGSYA-GAVVAMPLAGVLVQYIGWSSVFYIYGMFGIiwymfwlL 267
Cdd:cd17504 91 RALQGIGGAVF-PLAFALVREEFPP-ERVPVAQGILSATFGiGAGIGLPLGGWIVQHLGWRWIFWTAAPVAV-------L 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 268 QAYECPaahptisneektyietsigeganVVSLskfstpwkRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEE---- 343
Cdd:cd17504 162 LAALVP-----------------------LIDL--------RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptpt 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 344 VFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTtavrkimncgGFGMEATLLLVVGFSHTKGVAISF--LV 421
Cdd:cd17504 211 GFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLI----------GLVISAVGLLLLALLHSSLWALVValLL 280
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 74723817 422 LAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:cd17504 281 IGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
324-490 |
1.39e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.42 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 324 FCRSWTFYLLLISQPAY--FEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRsrqiltttaVRKIMNCGGFGMEA 401
Cdd:cd06174 3 LGFFLTGLARGLISPLLpaLLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG---------RRPVLLLGLLLFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 402 TLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTrEEWQ 481
Cdd:cd06174 74 GALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG-FGWR 152
|
....*....
gi 74723817 482 NVFLIAALV 490
Cdd:cd06174 153 AVFLIAAAL 161
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
315-463 |
1.95e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.17 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 315 PVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAvpHMVMTIV-VPIGGQLADYLRSRQILTttavrkimn 393
Cdd:cd17478 196 ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSL--FLFAGAIgTLIGGPLSDRFGRRRVII--------- 264
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74723817 394 cggFGMEATLLLVVGFSHTKGVAISFLVLAVGFsgFAISGFNVNHL---DIAPRYA----SILMGISNGVGTLSGMV 463
Cdd:cd17478 265 ---ASLLLAAPFLLLFLLTPGIWSYILLVLAGF--LLFASFPVTVVlaqELLPGNVglasGLMMGLSFGLGGIGAPV 336
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
129-474 |
2.09e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.93 E-value: 2.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 129 VGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLnmFIPSAARVHYGCVMCVRILQGLVEGV----TYPACH 204
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLA--LALIFATPSIYLFVVLMFLAGLGAGIldtgANTFVG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 205 GMWSKWAPplerSRLATTSFCGSyAGAVVAMPLAGVLV-QYIGWSSVFYIYGMFGIIWYMFWLLqayecpaahPTISNEE 283
Cdd:cd17333 111 ALFEESSA----TRLNVLHGFFG-LGALIGPLIATSLLtSELSWSWAYLIIGLIYLLLAILILL---------TLFPELP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 284 KTYIETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTfylllisqPAYFEEVFGFAISKVGLLSAVPHMVM 363
Cdd:cd17333 177 SARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWV--------PSYLVEKKHVSDGLAGYLLSGFWVGI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 364 TIVVPIGGQLADYLRSRQILTTTAVrkimncggfgmEATLLLVVGFSHTKGVAISFLVLAVGFSgfaISG----FNVNHL 439
Cdd:cd17333 249 TIGRLLGGPISRRIKPHTLLVLSGS-----------GALLGLLILLLAPTLVVGLVATALLGLF---MAAlfptILSLGI 314
|
330 340 350
....*....|....*....|....*....|....*
gi 74723817 440 DIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRH 474
Cdd:cd17333 315 SNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEA 349
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
108-463 |
2.61e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.80 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 108 TVYVDGKPEIQTAqFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRV--FGAAIF-LTSTLNMFIPSaarvhYGC 184
Cdd:cd17320 16 DMYLPALPAIARD-LGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVllAGLLLFiLASLLCALASS-----IEQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 185 VMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLAttsfcgSYAGAVVAM-----PLAG-VLVQYIGWSSVFYIYGMFG 258
Cdd:cd17320 90 LLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIF------SLLMMILAIapalaPLLGgLLLLFFGWRAIFVFLALLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 259 II---WYMFWLlqayecPAAHPtiSNEEKTYIETSIGEGANVVSlskfstpwKRFFTSlpvYAIIVAnfCRSWTFYLLLI 335
Cdd:cd17320 164 LLlllLVLLFL------PETLP--EEKRKPLLSSLLRAYKRVLK--------NRRFLG---YALALG--LSFAGLFAYLA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 336 SQPAYFEEVFGFAISKVGLLsavphMVMTIVVPIGGQLAdylrSRQILTTTAVRKIMNCG--GFGMEATLLLVVGFSHTK 413
Cdd:cd17320 223 AAPFIYIEQLGLSPAQFGLL-----FALNAIALILGSLL----NGRLVRRFGPRRLLRLGllLLLAAALVLLLAALLGGL 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 74723817 414 GVAISFLVLAVGFSGFAISGFNVNHLDIAPRY-----ASILMG-ISNGVGTLSGMV 463
Cdd:cd17320 294 SLWPLVAPLFLIFFGFGLIFPNATSLALEPFPhvagtASALLGfLQFLIGALAGAL 349
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
318-490 |
1.64e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.03 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 318 AIIVANFCRSWTFYLLLISQPAYFEEvFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVrkimncgGF 397
Cdd:COG0477 18 ALALGTFLEGLDFTIVNVALPSIAAD-LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL-------LF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 398 GMeATLLLvvGFSHTkgvaISFLVLAVGFSGFAISGFNVNHL----DIAP-RYASILMGISNGVGTLSGMVCPLIVGAMT 472
Cdd:COG0477 90 GL-ASLLC--GLAPS----PELLIAARALQGIGAGGLMPGALaliaELFPaRERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170
....*....|....*...
gi 74723817 473 RHKTreeWQNVFLIAALV 490
Cdd:COG0477 163 AALG---WRWIFLINAPL 177
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
314-490 |
1.67e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.07 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 314 LPVYAIIVANFCRSWTFYLLLISQPaYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTtavrkimn 393
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL-------- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 394 cgGFGMEATLLLVVGFSHTKGV-AISFLVLAVGFSGFAISGfNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMT 472
Cdd:COG0738 79 --GLLLMALGLLLFALAPSYPLlLLALFLLGLGLGLLDVAA-NPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLI 155
|
170
....*....|....*...
gi 74723817 473 RHKTREEWQNVFLIAALV 490
Cdd:COG0738 156 LLGLSLSWHLPYLILAVL 173
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
159-260 |
1.71e-04 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 41.87 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 159 VFGAAIFLTSTlnmfIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLA 238
Cdd:TIGR00880 32 LVGLFIFVLST----AMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIALGPLLGPPLG 107
|
90 100
....*....|....*....|..
gi 74723817 239 GVLVQYIGWSSVFYIYGMFGII 260
Cdd:TIGR00880 108 GVLAQFLGWRAPFLFLAILALA 129
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
145-469 |
1.81e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.16 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 145 IPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARvHYGCVMCVRILQGLVeGVTYPACHGMWSKWAPPLERSRLATTSF 224
Cdd:cd17341 52 LPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVS-SYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 225 CGSYAGAVVA---MPLA----GVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAhptisneektyietsigeganV 297
Cdd:cd17341 130 GAGNMGVAVSqllAPLIagaiVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTG---------------------K 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 298 VSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYL 377
Cdd:cd17341 189 ASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 378 RSRQILTTtavrkimncGGFGMEATLLLVVGFSHTKGVAIS-FLVLAVGFSGFAISGFN-VNHL--DIAPRYASILMGIS 453
Cdd:cd17341 269 GGRRRLWW---------LFIVMTIGAALLSLSLPTSGTNLVlFLALFVALGLGAGAGNGsVFRMvpFIFRRELGAVTGLV 339
|
330
....*....|....*.
gi 74723817 454 NGVGTLSGMVCPLIVG 469
Cdd:cd17341 340 GAIGGLGGFFLPLLFG 355
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
129-498 |
2.15e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 129 VGLIHGSFFWGYIMTQIPGGFISNKFAANRV--FGAAIFLTSTLNMFIPSAARVhygcVMCVRILQGLVEGVTYPACHGM 206
Cdd:cd17489 33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLllIGLLIFALATLLYLLATSVAL----LLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 207 WSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGII-WYMFWLLqayecpaahptisneekT 285
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLaLLLVFLV-----------------K 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 286 YIETSIGEGANVVSLSKFSTPWKRFftsLPVYAIIvanFCRSWTFYLLLISQPAYFEEVFgfaISKVGLLSAVPHMVMTI 365
Cdd:cd17489 172 DPPPVAAEEAEAGTRAFRRLVEKKV---LPPALIL---FLASIAYGAISTFLPLYAAERG---ISNAGLFFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 366 VVPIGGQLADYLRsrqiltttavRKIMNCGGFGMEATLLLVVGFSHTKGVA-ISFLVLAVGFsGFAISGFNVNHLDIAPR 444
Cdd:cd17489 243 SRPFSGKLSDRKG----------PKTVIIPGLLLLALGLLLLSFAGSPWMLlLAAVLYGLGF-GLLFPALQALAVDLVPP 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74723817 445 YA--------SILMGISNGVGT-LSGMVCPLIvgamtrhktreEWQNVFLIAALVHYSGVIFY 498
Cdd:cd17489 312 HRrgaangtfFIFFDLGIGLGGlLLGLVAELF-----------GYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
122-260 |
2.56e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.72 E-value: 2.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 122 FNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYgcVMCVRILQGLVEGVTYP 201
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWL--LLLLLALLGLGLGLVFP 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 202 ACHGMWSKWAPPLERSR-LATTSFCGSyAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGII 260
Cdd:cd17325 308 ATLALLADIVPPEGRGTaMGLFNTAFS-LGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
125-490 |
4.17e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.99 E-value: 4.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 125 DPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRV---FGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYP 201
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLlilADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 202 ACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYG---MFGIIWYMFWllqayecPAAHPT 278
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINAlsfLLSALLLLFI-------RRPPPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 279 ISNEEKTYIETSIGEGanvvslskfstpWKRFFTSLPVYAIIVANFCrSWTFYLLLISQ-PAYFEEVFGFAISKVGLLSA 357
Cdd:cd06173 185 APGESSSLLLRDLREG------------LRYLRRSPLLRLLLLALAL-FALLGGALTVLlPLLAKEVLGGGAAGYGLLLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 358 VPhmvmtivvPIGGQLADYLRSRqILTTTAVRKIMNCGGFGMeATLLLVVGFSHTKGVAISFLVLAvgfsGFAISGFNVN 437
Cdd:cd06173 252 AF--------GVGALLGALLLGR-LSKRRRRGRLLLIGALLL-GLALLVLGLSPSLWLLLAALFLL----GLAGGLFNVP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 74723817 438 -----HLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTrhkTREEWQNVFLIAALV 490
Cdd:cd06173 318 lntllQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA---DALGLSAVFLLAGAL 372
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
128-490 |
6.82e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.23 E-value: 6.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 128 TVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTlnMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMW 207
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 208 SKWAPPLERS-----RLATTSFcGSYAGAVVAMPLAGVLvqyiGWSSVFYIYGMFGIIW-YMFWL-LQAYECPAAHPTIS 280
Cdd:cd17475 110 MRWFPPRERGlamgiRQTGVPL-GGALAAALLPPLALHY----GWRAAFVVAGLVSILAaVLFWLfYREPPAASAATESA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 281 NEEKTYIetsigeganvvslskfstpwKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPH 360
Cdd:cd17475 185 STLLRSL--------------------KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 361 ---MVMTIVVpigGQLADYLRSRQiltttaVRKIMNC-GGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNV 436
Cdd:cd17475 245 lggALGRIGL---GRVSDRVFGGR------RRPVLVItAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 74723817 437 NHL-DIAP-RYASILMGISNGVGTLSGMVCPLIVGAM--TRHKTREEWQNVFLIAALV 490
Cdd:cd17475 316 TLVaESAGpEQAGTALGLANTINFIGIAIGPPLFGLLvdATHSYAPAWLALALLLVLA 373
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
121-472 |
7.77e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 42.23 E-value: 7.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 121 QFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCV--RILQGLVEGV 198
Cdd:cd17345 32 QYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFilLFLNGWFQGM 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 199 TYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIG---WSSVFYIYGMFGIIWYMFWLLQAYECPAA 275
Cdd:cd17345 112 GWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPES 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 276 H--PTISNEEKTYIETSIGEGAnVVSLSKFSTPWKRFFTSLPVYAIIVAN----FCR----SWTfylllisqPAYFEEVF 345
Cdd:cd17345 192 EglPPIEEYKGDYPEEADGEEE-EQELSAWEIFVKYVLKNKLLWYIAIANvfvyLVRygilDWA--------PTYLSEVK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 346 GFAISKVGL------LSAVPHMVmtivvpIGGQLAD-YLRSRqiltttavRKIMNCggFGMEATLLLVVGFSHTKGVAIS 418
Cdd:cd17345 263 GFSKAQAMWafslfeWAAIPGTL------LAGWLSDkLFKGR--------RAPTGI--IFMILVIVALIVYWLAPNVLVD 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 419 FLVLAvgFSGFAISG----FNVNHLDIAPRYAsilmgisngVGTLSGM--VCPLIVGAMT 472
Cdd:cd17345 327 LIALI--ALGFLIYGpvmlIGLQALELVPKKA---------AGTAAGLtgLFGYLGGSVL 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
338-504 |
8.40e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 8.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 338 PAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQ------ILTTTavrkIMNCGGFGMeatLLLVVGFSH 411
Cdd:COG2211 34 LYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwILIGA----IPLALSFVL---LFTAPDLSP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 412 TkGVAISFLVLAVGFsGFAISGFNVNHL----DIAPRYA--SILMGISNGVGTLSGMVCPLIVGAMTRH---KTREEWQN 482
Cdd:COG2211 107 T-GKLIYALVTYLLL-GLAYTLVNIPYSalgaELTPDYEerTRLSSWRFAFAGLGGLLASVLPPPLVAAfggDAALGYRL 184
|
170 180
....*....|....*....|..
gi 74723817 483 VFLIAALVhysGVIFYGVFASG 504
Cdd:COG2211 185 TALIFAVL---GLLAFLLTFFG 203
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
119-497 |
1.06e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.52 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 119 TAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVF-----GAAIFltSTLNMFIPSaarvhYGCVMCVRILQG 193
Cdd:cd17371 26 IAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLvitilLFAVF--TLLCGFAQN-----YWQLLILRALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 194 LVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQY----IGWSSVFyiygMFGII-----WYMF 264
Cdd:cd17371 99 LGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLF----LLGALpallvLFIR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 265 WLLQAYECPAAHptisneektyiETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFcrswTFYLLLISQPAYFEEV 344
Cdd:cd17371 175 RFVKEPPQWQAA-----------RAARRHFADRPSLRELFSPPLLRTTLLASLLATGALG----GYYGITTWLPSYLTGE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 345 FGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTttavrkIMNCGGFgmeATLLLVVGFSHTKGVaISFLVLAV 424
Cdd:cd17371 240 RGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFA------LFALGSA---ISILLYFFLPLSPTL-ILILGFPL 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74723817 425 GFSGFAISGFNVNHLDIA--PRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTreeWQNVFLIAALVHYSGVIF 497
Cdd:cd17371 310 GFFASGPFSGMGAYLTELfpTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGS---LGTAIAVFAAVYYIAGLV 381
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
77-471 |
1.44e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.10 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 77 IIAIMSGLGFCISFGIRCNLGVAIVemvnnstvyvdgkPEIQtaQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAA 156
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFII-------------PIIA--EFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGP 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 157 NRV--FGAAIFLTSTLNMFIPSAARVHYGCvMCVriLQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVA 234
Cdd:cd17355 68 RRVmlLGLLLLAAGLVLLALATSLWQLYLL-WGL--LGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVF 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 235 MPLAGVLVQYIGWSSVFYIYGMFGII-----WYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSKFStpwkr 309
Cdd:cd17355 145 LPLGAALIEAFGWRTALLVLALLALLvlvpvLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAF----- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 310 FFTSLPVYAIIVanfcrswtfyllliSQPAYFEEvFGFAISKVGLLSAVpHMVMTIV-VPIGGQLADYLRSRQILTTtav 388
Cdd:cd17355 220 FLCGFAVVGLIV--------------HLVPYLAD-RGISPAAAAVALAL-IGLFNIVgRLLSGWLGDRYSPRRLLAA--- 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 389 rkimncgGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFA---ISGFNVNHLdIAPRYASILMGISNGVGTLSGMVCP 465
Cdd:cd17355 281 -------SYALRALGLALLLLLPFPPLALLLFAALFGLGWGAtvpLTAALAARY-FGARSYGTLFGLVFAPHQLGSALGP 352
|
....*.
gi 74723817 466 LIVGAM 471
Cdd:cd17355 353 WLGGLL 358
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
125-497 |
1.86e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 125 DPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIpsAARVHYGCVMCVRILQGLVeGVTYPACH 204
Cdd:cd17330 32 SGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL--GLSRNLWLLFLARFLDGLT-GGNVSVAQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 205 GMWSKWAPPLERSR-LATTSFCGSyAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGII--WYMFWLLqayecpaahptisn 281
Cdd:cd17330 109 AYIADITDEEERAKaFGIISAAFG-LGFILGPALGGFLSTPYGYALPFLVAAALALLnlVLVLFFL-------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 282 eektyietsigeganvvslskfstpwkrfftsLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHM 361
Cdd:cd17330 174 --------------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 362 VMTIVvpiggQLADYLRSRQILTTtavRKIMnCGGFGMEATLLLVVGFSHTKG---VAISFLVLAVGFSGFAISGFNVNH 438
Cdd:cd17330 222 AGILA-----QLLLIPRLAKRLGE---RKLL-RLGLLLAIIGLLLLPFASSVPllvLAAAILAFGTGIVFPALSALLSKS 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 74723817 439 LDIAPRyaSILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWqnvFLIAALVHYSGVIF 497
Cdd:cd17330 293 VPSKEQ--GKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVP---FLLAAGLLLIALFL 346
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
119-434 |
2.27e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.67 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 119 TAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRV--FGAAIFLTStlnmFIPSAARVHYGCV-MCVRILQGLV 195
Cdd:cd17353 30 SSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAilIGGILFGLG----FILSAFAISLPLLfLGYGVLGGIG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 196 EGVTYPACHGMWSKWAPplERSRLAT-TSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYG-MFGIIwyMFWLLQAYECP 273
Cdd:cd17353 106 AGIGYITPVSTAVKWFP--DKRGLATgIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGiIFLII--IVIGAFLIRDP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 274 AAHPTISneektyiETSIGEGANVVSLSKFStpWKRFFTSlPVYAIIVANFCRSWTFYLLLISQPAYF-EEVFGFAISKV 352
Cdd:cd17353 182 PKGWVPP-------GVDPLANNAENSPRDYT--PREMLRT-PTFWLLWLMFFLNATAGLMLIGQAKPIgQEFAGLDAGIA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 353 GLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVrkimnCGGFGMeatlllvVGFSHTKGVAISFlVLAVGFSGFAIS 432
Cdd:cd17353 252 ALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFL-----IQGVAM-------FLLPFIGSVAVLF-VLGVALIGFCYG 318
|
..
gi 74723817 433 GF 434
Cdd:cd17353 319 GG 320
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
128-474 |
3.12e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.29 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 128 TVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVriLQGLVEGVTYPACHGMW 207
Cdd:cd17329 36 IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV--LTGFGGGLFEPASEAMI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 208 SKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYiGWSSVFYI-YGMFGIiwYMFWLLQAYecpaahPTISNEEKTY 286
Cdd:cd17329 114 ADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAaAVLFLL--AALVLLFLL------PETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 287 IETSIGEGanvvslskfstpWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVpHMVMTIV 366
Cdd:cd17329 185 EKTEILRG------------YKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLAL-NALLIVL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 367 --VPIGGQLADYLRSRQILTttavrkimncgGFGMEATLLLVVGFSHTKGVAISF-LVLAVGFSgFAISGFNVNHLDIAP 443
Cdd:cd17329 252 lqFPVARLVERFRLRKILMI-----------GILLFAIGFAVLAFANTLAVLILAmIVLTLGEM-LVFPAVQTLVAALAP 319
|
330 340 350
....*....|....*....|....*....|....*.
gi 74723817 444 -----RYasilMGISNGVGTLSGMVCPLIVGAMTRH 474
Cdd:cd17329 320 pdkrgSY----MGFYALAWGLGRAIGPLVGGLLLDL 351
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
340-490 |
7.69e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 7.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74723817 340 YFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILtttavrkimnCGGFGMEATLLLVVGFSHTKGVaisf 419
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLL----------PLGPLLTGLGLSLLGFAPNYWL---- 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74723817 420 LVLAVGFSGFAISGFNVnhldIAPRYASILMGISNGV--------GTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALV 490
Cdd:cd17478 87 LLLLVALAGIGSAAFHP----EGARLASQAAGGRRGLamsifsvgGNLGFALGPLIAAALVALFGGLGLLILLIIPGLA 161
|
|
| |
