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Conserved domains on  [gi|37537808|sp|Q8R349|]
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RecName: Full=Cell division cycle protein 16 homolog; AltName: Full=Anaphase-promoting complex subunit 6; Short=APC6; AltName: Full=Cyclosome subunit 6

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-94 2.15e-21

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


:

Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 88.46  E-value: 2.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808    15 DQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDILD 94
Cdd:pfam12895   1 DQHQYKNAIFLAERLLAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
373-522 5.95e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 75.04  E-value: 5.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 373 YIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEkikaignevTVDKWEPLLNNLG 452
Cdd:COG0457  13 NLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE---------LDPDDAEALNNLG 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 453 HVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 522
Cdd:COG0457  84 LALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 275-440 6.00e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.77  E-value: 6.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 275 LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAM 354
Cdd:COG3914  88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 355 AAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKwFLDALEKIKA 434
Cdd:COG3914 167 AALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR-FEELLAALAR 245


                ....*.
gi 37537808 435 IGNEVT 440
Cdd:COG3914 246 GPSELS 251
LapB super family cl34526
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 13-182 7.83e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG2956:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.56  E-value: 7.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808  13 YLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRS-RKLDKLYEACRYLAARCHYAAKEHQQALD 91
Cdd:COG2956  52 YRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKlLELDPDDAEALRLLAEIYEQEGDWEKAIE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808  92 ILdmeepinrrlfEKYLKDDNGSrdpssdwemsqssikSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLT 171
Cdd:COG2956 132 VL-----------ERLLKLGPEN---------------AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLA 185

                       170
                ....*....|.
gi 37537808 172 SHHMLTAQEEK 182
Cdd:COG2956 186 ELYLEQGDYEE 196
 
Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-94 2.15e-21

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 88.46  E-value: 2.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808    15 DQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDILD 94
Cdd:pfam12895   1 DQHQYKNAIFLAERLLAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
373-522 5.95e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 75.04  E-value: 5.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 373 YIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEkikaignevTVDKWEPLLNNLG 452
Cdd:COG0457  13 NLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE---------LDPDDAEALNNLG 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 453 HVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 522
Cdd:COG0457  84 LALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153
TPR_12 pfam13424
Tetratricopeptide repeat;
447-511 5.29e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.46  E-value: 5.29e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 37537808   447 LLNNLGHVCRKLKKYAEALDYHRQALVLI--------PQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRD 511
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 275-440 6.00e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.77  E-value: 6.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 275 LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAM 354
Cdd:COG3914  88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 355 AAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKwFLDALEKIKA 434
Cdd:COG3914 167 AALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR-FEELLAALAR 245


                ....*.
gi 37537808 435 IGNEVT 440
Cdd:COG3914 246 GPSELS 251
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 2-129 4.62e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.23  E-value: 4.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   2 NLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHAL-RSRKLDKLYEACRYLAARCH 80
Cdd:COG4235  16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLeRALALDPDNPEALYLLGLAA 95

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 37537808  81 YAAKEHQQALDildmeepinrrLFEKYLKDDngsrDPSSDWEMSQSSIK 129
Cdd:COG4235  96 FQQGDYAEAIA-----------AWQKLLALL----PADAPARLLEASIA 129
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 229-508 4.83e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.70  E-value: 4.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   229 ENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCY 308
Cdd:TIGR02917 531 KNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRA 610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   309 YLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAY---------FTAAQLMKGCHL---------- 369
Cdd:TIGR02917 611 QLAAGDLNK-AVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLkralelkpdNTEAQIGLAQLLlaakrtesak 689

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   370 ----------PMLYIGLE-----YGLTNNSKLAERFFGQALSIAPEDPFVI--HEVGVVAFQNGE-WKTAEKW------- 424
Cdd:TIGR02917 690 kiakslqkqhPKAALGFElegdlYLRQKDYPAAIQAYRKALKRAPSSQNAIklHRALLASGNTAEaVKTLEAWlkthpnd 769

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   425 ----------FLDALEKIKAIGNEVTVDKWEP----LLNNLGHVCRKLKKyAEALDYHRQALVLIPQNASTYSAIGYIHS 490
Cdd:TIGR02917 770 avlrtalaelYLAQKDYDKAIKHYQTVVKKAPdnavVLNNLAWLYLELKD-PRALEYAERALKLAPNIPAILDTLGWLLV 848

                         330
                  ....*....|....*...
gi 37537808   491 LMGNFENAVDYFHTALGL 508
Cdd:TIGR02917 849 EKGEADRALPLLRKAVNI 866
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 134-502 1.25e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   134 LLRGKIYDALDNRTLATYSYKEALKLD-----VYCFEAFDLLTSHHMLTAQEEKE-LLDSLPLNKLCAEEQELLRFvfen 207
Cdd:TIGR02917 197 LLKGDLLLSLGNIELALAAYRKAIALRpnniaVLLALATILIEAGEFEEAEKHADaLLKKAPNSPLAHYLKALVDF---- 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   208 KLKKYNKPSETVIpESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLVELNKANELFYL 287
Cdd:TIGR02917 273 QKKNYEDARETLQ-DALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIAT 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   288 SHKLVDLYPSNPVSWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQL---- 363
Cdd:TIGR02917 352 LSPALGLDPDDPAALSLLGEAYLALG-DFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLdpel 430

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   364 ------------------------------MKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAF 413
Cdd:TIGR02917 431 gradlllilsylrsgqfdkalaaakklekkQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDI 510

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   414 QNGEWKTAEKWFLDAL----EKIKAI----------GNEVTVDKW------------EPLLnNLGHVCRKLKKYAEALDY 467
Cdd:TIGR02917 511 QEGNPDDAIQRFEKVLtidpKNLRAIlalaglylrtGNEEEAVAWlekaaelnpqeiEPAL-ALAQYYLGKGQLKKALAI 589

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 37537808   468 HRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYF 502
Cdd:TIGR02917 590 LNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSF 624
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 375-520 1.55e-05

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 46.56  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   375 GLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALekikAIGNEVTvdkwePLLNNLGHV 454
Cdd:TIGR02521  38 ALGYLEQGDLEVAKENLDKALEHDPDDYLAYLALALYYQQLGELEKAEDSFRRAL----TLNPNNG-----DVLNNYGTF 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 37537808   455 CRKLKKYAEALDYHRQALV--LIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDdtFSVTMLG 520
Cdd:TIGR02521 109 LCQQGKYEQAMQQFEQAIEdpLYPQPARSLENAGLCALKAGDFDKAEKYLTRALQIDPQ--RPESLLE 174
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 448-478 6.48e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.12  E-value: 6.48e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 37537808    448 LNNLGHVCRKLKKYAEALDYHRQALVLIPQN 478
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 13-182 7.83e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.56  E-value: 7.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808  13 YLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRS-RKLDKLYEACRYLAARCHYAAKEHQQALD 91
Cdd:COG2956  52 YRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKlLELDPDDAEALRLLAEIYEQEGDWEKAIE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808  92 ILdmeepinrrlfEKYLKDDNGSrdpssdwemsqssikSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLT 171
Cdd:COG2956 132 VL-----------ERLLKLGPEN---------------AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLA 185

                       170
                ....*....|.
gi 37537808 172 SHHMLTAQEEK 182
Cdd:COG2956 186 ELYLEQGDYEE 196
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 461-508 9.26e-03

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 37.34  E-value: 9.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 37537808  461 YAEALDYHRQALVLiPQNASTYSAI----GYIHSLMGNFENAVDYFHTALGL 508
Cdd:PRK02603  51 YAEALENYEEALKL-EEDPNDRSYIlynmGIIYASNGEHDKALEYYHQALEL 101
 
Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-94 2.15e-21

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 88.46  E-value: 2.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808    15 DQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDILD 94
Cdd:pfam12895   1 DQHQYKNAIFLAERLLAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
373-522 5.95e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 75.04  E-value: 5.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 373 YIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEkikaignevTVDKWEPLLNNLG 452
Cdd:COG0457  13 NLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE---------LDPDDAEALNNLG 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 453 HVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 522
Cdd:COG0457  84 LALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
329-512 6.48e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 74.66  E-value: 6.48e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 329 LEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEV 408
Cdd:COG0457   3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 409 GVVAFQNGEWKTAEKWFLDALEkikaIGNEVtvdkwEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYI 488
Cdd:COG0457  83 GLALQALGRYEEALEDYDKALE----LDPDD-----AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153

                       170       180
                ....*....|....*....|....
gi 37537808 489 HSLMGNFENAVDYFHTALGLRRDD 512
Cdd:COG0457 154 LEKLGRYEEALELLEKLEAAALAA 177
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 366-512 5.71e-14

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 69.45  E-value: 5.71e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 366 GCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEkikaignevtVDKWE 445
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALE----------LDPDE 71

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 37537808 446 P-LLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDD 512
Cdd:COG4783  72 PeARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 301-522 1.14e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 71.68  E-value: 1.14e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 301 SWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGL 380
Cdd:COG2956  10 GWYFKGLNYLLNG-QPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLK 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 381 TNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAekwfLDALEKIKAIGnevtvDKWEPLLNNLGHVCRKLKK 460
Cdd:COG2956  89 AGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKA----IEVLERLLKLG-----PENAHAYCELAELYLEQGD 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37537808 461 YAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 522
Cdd:COG2956 160 YDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 277-532 1.72e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 71.30  E-value: 1.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 277 ELNKANELFylsHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAA 356
Cdd:COG2956  23 QPDKAIDLL---EEALELDPETVEAHLALGNLYRRRGEYDR-AIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEEL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 357 YFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKIKaig 436
Cdd:COG2956  99 LEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDP--- 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 437 nevtvdKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFsV 516
Cdd:COG2956 176 ------DCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL-L 248

                       250
                ....*....|....*.
gi 37537808 517 TMLGHCIEMYIGDSEA 532
Cdd:COG2956 249 LALADLLERKEGLEAA 264
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 381-533 2.56e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 73.10  E-value: 2.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 381 TNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKikaignevtVDKWEPLLNNLGHVCRKLKK 460
Cdd:COG3914  91 LGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALAL---------NPDFAEAYLNLGEALRRLGR 161

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 37537808 461 YAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIeMYIGDSEAY 533
Cdd:COG3914 162 LEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL-RQACDWEVY 233
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
395-522 4.01e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 69.65  E-value: 4.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 395 LSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEkikaignevtVDKWEP-LLNNLGHVCRKLKKYAEALDYHRQALV 473
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALE----------LDPDDAeALYNLGLAYLRLGRYEEALADYEQALE 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 37537808 474 LIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 522
Cdd:COG0457  71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 290-506 1.56e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.14  E-value: 1.56e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 290 KLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHL 369
Cdd:COG2956  67 KLLERDPDRAEALLELAQDYLKAGLLDR-AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 370 PMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKikaignevtVDKWEPLLN 449
Cdd:COG2956 146 AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ---------DPDYLPALP 216

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 37537808 450 NLGHVCRKLKKYAEALDYHRQALVLIPQNASTYsAIGYIHSLMGNFENAVDYFHTAL 506
Cdd:COG2956 217 RLAELYEKLGDPEEALELLRKALELDPSDDLLL-ALADLLERKEGLEAALALLERQL 272
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 349-492 1.52e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.78  E-value: 1.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 349 EHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDA 428
Cdd:COG3914  93 RYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRA 172

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37537808 429 LEkikaigneVTVDKWEpLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAigYIHSLM 492
Cdd:COG3914 173 LE--------LDPDNAE-ALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN--LLFALR 225
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 369-520 6.67e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.43  E-value: 6.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 369 LPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKikaignevtVDKWEPLL 448
Cdd:COG2956   9 LGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLER---------DPDRAEAL 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37537808 449 NNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 520
Cdd:COG2956  80 LELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELA 151
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
411-511 9.80e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 52.87  E-value: 9.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 411 VAFQNGEWKTAEKWFLDALEKIKAIGNevtvdkwepLLNNLGHVCRKLKKYAEALDYhRQALVLIPQNASTYSAIGYIHS 490
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNAD---------ALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLL 70

                        90       100
                ....*....|....*....|.
gi 37537808 491 LMGNFENAVDYFHTALGLRRD 511
Cdd:COG3063  71 ELGDYDEALAYLERALELDPS 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
290-479 2.87e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.01  E-value: 2.87e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 290 KLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHL 369
Cdd:COG0457  33 KALELDPDDAEALYNLGLAYLRLGRYEE-ALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAE 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 370 PMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLN 449
Cdd:COG0457 112 ALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALA 191

                       170       180       190
                ....*....|....*....|....*....|
gi 37537808 450 NLGHVCRKLKKYAEALDYHRQALVLIPQNA 479
Cdd:COG0457 192 AAEVLLALLLALEQALRKKLAILTLAALAE 221
TPR_12 pfam13424
Tetratricopeptide repeat;
447-511 5.29e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.46  E-value: 5.29e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 37537808   447 LLNNLGHVCRKLKKYAEALDYHRQALVLI--------PQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRD 511
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 275-440 6.00e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.77  E-value: 6.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 275 LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAM 354
Cdd:COG3914  88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 355 AAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKwFLDALEKIKA 434
Cdd:COG3914 167 AALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR-FEELLAALAR 245


                ....*.
gi 37537808 435 IGNEVT 440
Cdd:COG3914 246 GPSELS 251
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 409-522 9.61e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.35  E-value: 9.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 409 GVVAFQNGEWKTAEKWFLDALEKikaignevtVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYI 488
Cdd:COG4783  11 AQALLLAGDYDEAEALLEKALEL---------DPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                        90       100       110
                ....*....|....*....|....*....|....
gi 37537808 489 HSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 522
Cdd:COG4783  82 LLKAGDYDEALALLEKALKLDPEHPEAYLRLARA 115
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 302-431 2.00e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.58  E-value: 2.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 302 WFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLT 381
Cdd:COG4783   7 LYALAQALLLAGDYDE-AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKA 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 37537808 382 NNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEK 431
Cdd:COG4783  86 GDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 378-476 2.89e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.34  E-value: 2.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 378 YGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKIKAignevtvdkWEPLLNNLGHVCRK 457
Cdd:COG5010  64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPD---------NPNAYSNLAALLLS 134

                        90
                ....*....|....*....
gi 37537808 458 LKKYAEALDYHRQALVLIP 476
Cdd:COG5010 135 LGQDDEAKAALQRALGTSP 153
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 2-129 4.62e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.23  E-value: 4.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   2 NLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHAL-RSRKLDKLYEACRYLAARCH 80
Cdd:COG4235  16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLeRALALDPDNPEALYLLGLAA 95

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 37537808  81 YAAKEHQQALDildmeepinrrLFEKYLKDDngsrDPSSDWEMSQSSIK 129
Cdd:COG4235  96 FQQGDYAEAIA-----------AWQKLLALL----PADAPARLLEASIA 129
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 410-508 6.21e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.57  E-value: 6.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 410 VVAFQNGEWKTAEKWFLDALEKIKaignevtvdKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIH 489
Cdd:COG5010  62 NLYNKLGDFEESLALLEQALQLDP---------NNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALL 132

                        90
                ....*....|....*....
gi 37537808 490 SLMGNFENAVDYFHTALGL 508
Cdd:COG5010 133 LSLGQDDEAKAALQRALGT 151
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 454-520 7.96e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.19  E-value: 7.96e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37537808 454 VCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 520
Cdd:COG5010  63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLA 129
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 336-430 3.86e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 3.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 336 AWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQN 415
Cdd:COG4235  19 GWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQ 98

                        90
                ....*....|....*
gi 37537808 416 GEWKTAEKWFLDALE 430
Cdd:COG4235  99 GDYAEAIAAWQKLLA 113
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 393-512 4.77e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 4.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 393 QALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEkikaignevtVDKWEP-LLNNLGHVCRKLKKYAEALDYHRQA 471
Cdd:COG4235   8 QALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALR----------LDPDNAdALLDLAEALLAAGDTEEAEELLERA 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 37537808 472 LVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDD 512
Cdd:COG4235  78 LALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 229-508 4.83e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.70  E-value: 4.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   229 ENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCY 308
Cdd:TIGR02917 531 KNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRA 610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   309 YLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAY---------FTAAQLMKGCHL---------- 369
Cdd:TIGR02917 611 QLAAGDLNK-AVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLkralelkpdNTEAQIGLAQLLlaakrtesak 689

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   370 ----------PMLYIGLE-----YGLTNNSKLAERFFGQALSIAPEDPFVI--HEVGVVAFQNGE-WKTAEKW------- 424
Cdd:TIGR02917 690 kiakslqkqhPKAALGFElegdlYLRQKDYPAAIQAYRKALKRAPSSQNAIklHRALLASGNTAEaVKTLEAWlkthpnd 769

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   425 ----------FLDALEKIKAIGNEVTVDKWEP----LLNNLGHVCRKLKKyAEALDYHRQALVLIPQNASTYSAIGYIHS 490
Cdd:TIGR02917 770 avlrtalaelYLAQKDYDKAIKHYQTVVKKAPdnavVLNNLAWLYLELKD-PRALEYAERALKLAPNIPAILDTLGWLLV 848

                         330
                  ....*....|....*...
gi 37537808   491 LMGNFENAVDYFHTALGL 508
Cdd:TIGR02917 849 EKGEADRALPLLRKAVNI 866
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 308-430 8.97e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.11  E-value: 8.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 308 YYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLA 387
Cdd:COG5010  28 EAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEA 107

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 37537808 388 ERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALE 430
Cdd:COG5010 108 KEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALG 150
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 134-502 1.25e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   134 LLRGKIYDALDNRTLATYSYKEALKLD-----VYCFEAFDLLTSHHMLTAQEEKE-LLDSLPLNKLCAEEQELLRFvfen 207
Cdd:TIGR02917 197 LLKGDLLLSLGNIELALAAYRKAIALRpnniaVLLALATILIEAGEFEEAEKHADaLLKKAPNSPLAHYLKALVDF---- 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   208 KLKKYNKPSETVIpESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLVELNKANELFYL 287
Cdd:TIGR02917 273 QKKNYEDARETLQ-DALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIAT 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   288 SHKLVDLYPSNPVSWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQL---- 363
Cdd:TIGR02917 352 LSPALGLDPDDPAALSLLGEAYLALG-DFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLdpel 430

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   364 ------------------------------MKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAF 413
Cdd:TIGR02917 431 gradlllilsylrsgqfdkalaaakklekkQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDI 510

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   414 QNGEWKTAEKWFLDAL----EKIKAI----------GNEVTVDKW------------EPLLnNLGHVCRKLKKYAEALDY 467
Cdd:TIGR02917 511 QEGNPDDAIQRFEKVLtidpKNLRAIlalaglylrtGNEEEAVAWlekaaelnpqeiEPAL-ALAQYYLGKGQLKKALAI 589

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 37537808   468 HRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYF 502
Cdd:TIGR02917 590 LNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSF 624
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 375-520 1.55e-05

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 46.56  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   375 GLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALekikAIGNEVTvdkwePLLNNLGHV 454
Cdd:TIGR02521  38 ALGYLEQGDLEVAKENLDKALEHDPDDYLAYLALALYYQQLGELEKAEDSFRRAL----TLNPNNG-----DVLNNYGTF 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 37537808   455 CRKLKKYAEALDYHRQALV--LIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDdtFSVTMLG 520
Cdd:TIGR02521 109 LCQQGKYEQAMQQFEQAIEdpLYPQPARSLENAGLCALKAGDFDKAEKYLTRALQIDPQ--RPESLLE 174
TPR_12 pfam13424
Tetratricopeptide repeat;
406-472 2.40e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.76  E-value: 2.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37537808   406 HEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEpLLNNLGHVCRKLKKYAEALDYHRQAL 472
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTAT-TLLNLGRLYLELGRYEEALELLERAL 72
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 296-402 3.06e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.84  E-value: 3.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 296 PSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIG 375
Cdd:COG4235  14 PNDAEGWLLLGRAYLRLGRYDE-ALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG 92

                        90       100
                ....*....|....*....|....*..
gi 37537808 376 LEYGLTNNSKLAERFFGQALSIAPEDP 402
Cdd:COG4235  93 LAAFQQGDYAEAIAAWQKLLALLPADA 119
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 372-479 4.21e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.46  E-value: 4.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 372 LYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEkikaignevtVDKWEP-LLNN 450
Cdd:COG4235  21 LLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALA----------LDPDNPeALYL 90

                        90       100
                ....*....|....*....|....*....
gi 37537808 451 LGHVCRKLKKYAEALDYHRQALVLIPQNA 479
Cdd:COG4235  91 LGLAAFQQGDYAEAIAAWQKLLALLPADA 119
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 448-520 4.25e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 4.25e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 37537808 448 LNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 520
Cdd:COG4783   7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLG 79
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
447-515 4.40e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.29  E-value: 4.40e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 447 LLNNLGHVCRKLKKYAEAL-DYhRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFS 515
Cdd:COG4785  75 LYYERGVAYDSLGDYDLAIaDF-DQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 448-478 6.48e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.12  E-value: 6.48e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 37537808    448 LNNLGHVCRKLKKYAEALDYHRQALVLIPQN 478
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
448-478 8.68e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.71  E-value: 8.68e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 37537808   448 LNNLGHVCRKLKKYAEALDYHRQALVLIPQN 478
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 450-520 1.09e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.30  E-value: 1.09e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 37537808 450 NLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 520
Cdd:COG4235  22 LLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG 92
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
349-506 1.21e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 43.75  E-value: 1.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 349 EHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDA 428
Cdd:COG4785  88 DYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKA 167

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 37537808 429 LEKikaignevtvDKWEPLLNNLGHVCRKLKKYAEALDYHRQAlvlipqnastysaIGYIHSLMGNFENAVDYFHTAL 506
Cdd:COG4785 168 LEL----------DPNDPERALWLYLAERKLDPEKALALLLED-------------WATAYLLQGDTEEARELFKLAL 222
COG3899 COG3899
Predicted ATPase [General function prediction only];
318-511 1.22e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 45.23  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808  318 HAR--RYLSKATTLEKTYGPAWIAYgHsFAVESEHDQAMAAYFTAAQLMKGCHLPmlyigleygltnnsKLAERFFGQAL 395
Cdd:COG3899  669 HRRiaRALEARGPEPLEERLFELAH-H-LNRAGERDRAARLLLRAARRALARGAY--------------AEALRYLERAL 732

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808  396 SIAPEDPFVIHEV------GVVAFQNGEWKTAEKWFLDALEK--IKAIGNEVTVDKWEPL--LNNLGHVCRklKKYAEAL 465
Cdd:COG3899  733 ELLPPDPEEEYRLalllelAEALYLAGRFEEAEALLERALAAraLAALAALRHGNPPASAraYANLGLLLL--GDYEEAY 810

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 37537808  466 DYHRQALVLI------PQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRD 511
Cdd:COG3899  811 EFGELALALAerlgdrRLEARALFNLGFILHWLGPLREALELLREALEAGLE 862
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
454-521 3.29e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 3.29e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 37537808 454 VCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDyFHTALGLRRDDTFSVTMLGH 521
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAE 67
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-160 3.35e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 3.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   2 NLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHAL-RSRKLDKLYEACRYLAARCH 80
Cdd:COG2956 109 DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALeKALKLDPDCARALLLLAELY 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808  81 YAAKEHQQALDILdmeepinRRLFEkylkddngsRDPSSdwemsqssikSSICLLRGKIYDALDNRTLATYSYKEALKLD 160
Cdd:COG2956 189 LEQGDYEEAIAAL-------ERALE---------QDPDY----------LPALPRLAELYEKLGDPEEALELLRKALELD 242
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 315-399 4.54e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 4.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 315 KNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQA 394
Cdd:COG5010  69 DFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRA 148


                ....*
gi 37537808 395 LSIAP 399
Cdd:COG5010 149 LGTSP 153
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 373-506 4.99e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   373 YIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEkiKAIGNevtVDKWepllNNLG 452
Cdd:TIGR02917 130 LRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLT--ADPGN---VDAL----LLKG 200

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 37537808   453 HVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTAL 506
Cdd:TIGR02917 201 DLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALL 254
TPR_11 pfam13414
TPR repeat;
452-493 1.18e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 37.07  E-value: 1.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 37537808   452 GHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMG 493
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
13-94 1.26e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808  13 YLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDI 92
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81


                ..
gi 37537808  93 LD 94
Cdd:COG3063  82 LE 83
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
339-512 1.75e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.28  E-value: 1.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 339 AYGHSFAVESEHDQAMAAYFTAAQLMKGC-HLPMLYIGLE---YGLTNNSKLAERFFGQALSI-----APEDPFVIHEVG 409
Cdd:COG4785   1 LYALALALLLALALAAAAASKAAILLAALlFAAVLALAIAladLALALAAAALAAAALAAERIdralaLPDLAQLYYERG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 410 VVAFQNGEWKTAEKWFLDALEkikaignevTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIH 489
Cdd:COG4785  81 VAYDSLGDYDLAIADFDQALE---------LDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIAL 151

                       170       180
                ....*....|....*....|...
gi 37537808 490 SLMGNFENAVDYFHTALGLRRDD 512
Cdd:COG4785 152 YYLGRYELAIADLEKALELDPND 174
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 368-508 2.98e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   368 HLPMLYIG--LEYGLtNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEwktaekwFLDALEKIKAIGNEVTVDKwe 445
Cdd:TIGR02917 294 YLPALLLAgaSEYQL-GNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGR-------VDEAIATLSPALGLDPDDP-- 363

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 37537808   446 PLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL 508
Cdd:TIGR02917 364 AALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQL 426
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 274-363 4.78e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 4.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808 274 TLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQA 353
Cdd:COG4783  47 ILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE-ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEA 125

                        90
                ....*....|
gi 37537808 354 MAAYFTAAQL 363
Cdd:COG4783 126 IAALEKALEL 135
TPR_7 pfam13176
Tetratricopeptide repeat;
447-474 4.83e-03

Tetratricopeptide repeat;


Pssm-ID: 433012 [Multi-domain]  Cd Length: 36  Bit Score: 35.21  E-value: 4.83e-03
                          10        20
                  ....*....|....*....|....*...
gi 37537808   447 LLNNLGHVCRKLKKYAEALDYHRQALVL 474
Cdd:pfam13176   1 ALLNLGRIYRKLGDYDEAISLYEQALAL 28
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 2-93 4.87e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 4.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   2 NLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHAL-RSRKLDKLYEACRYLAARCH 80
Cdd:COG4783  37 NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLeKALKLDPEHPEAYLRLARAY 116

                        90
                ....*....|...
gi 37537808  81 YAAKEHQQALDIL 93
Cdd:COG4783 117 RALGRPDEAIAAL 129
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 3-160 5.11e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 5.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   3 LEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHAL-RSRKLDKLYEACRYLAARCHY 81
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLhEALELDPDEPEARLNLGLALL 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 37537808  82 AAKEHQQALdildmeepinrRLFEKYLKddngsRDPSSdwemsqssikSSICLLRGKIYDALDNRTLATYSYKEALKLD 160
Cdd:COG4783  84 KAGDYDEAL-----------ALLEKALK-----LDPEH----------PEAYLRLARAYRALGRPDEAIAALEKALELD 136
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 308-520 5.90e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.68  E-value: 5.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   308 YYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLA 387
Cdd:TIGR02917 167 QLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808   388 ERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAekwfLDALEKIKAIGNEvtvdkWEPLLNNLGHVCRKLKKYAEALDY 467
Cdd:TIGR02917 247 EKHADALLKKAPNSPLAHYLKALVDFQKKNYEDA----RETLQDALKSAPE-----YLPALLLAGASEYQLGNLEQAYQY 317

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 37537808   468 HRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 520
Cdd:TIGR02917 318 LNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLG 370
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 13-182 7.83e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.56  E-value: 7.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808  13 YLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRS-RKLDKLYEACRYLAARCHYAAKEHQQALD 91
Cdd:COG2956  52 YRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKlLELDPDDAEALRLLAEIYEQEGDWEKAIE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537808  92 ILdmeepinrrlfEKYLKDDNGSrdpssdwemsqssikSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLT 171
Cdd:COG2956 132 VL-----------ERLLKLGPEN---------------AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLA 185

                       170
                ....*....|.
gi 37537808 172 SHHMLTAQEEK 182
Cdd:COG2956 186 ELYLEQGDYEE 196
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 461-508 9.26e-03

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 37.34  E-value: 9.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 37537808  461 YAEALDYHRQALVLiPQNASTYSAI----GYIHSLMGNFENAVDYFHTALGL 508
Cdd:PRK02603  51 YAEALENYEEALKL-EEDPNDRSYIlynmGIIYASNGEHDKALEYYHQALEL 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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