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Conserved domains on  [gi|81901845|sp|Q8VCB2|]
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RecName: Full=Mediator of RNA polymerase II transcription subunit 25; AltName: Full=Mediator complex subunit 25; Short=mMED25

Protein Classification

Med25_VWA and Med25 domain-containing protein( domain architecture ID 12109167)

protein containing domains Med25_VWA, Med25_SD1, Med25, and Med25_NR-box

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med25_VWA pfam11265
Mediator complex subunit 25 von Willebrand factor type A; The overall function of the ...
 12-226 3.40e-119

Mediator complex subunit 25 von Willebrand factor type A; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex.


:

Pssm-ID: 463253  Cd Length: 213  Bit Score: 356.61  E-value: 3.40e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845    12 GGLVADVVFVIEGTANLGPYFEELRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSA 91
Cdd:pfam11265   1 SSVVADVVFVVEGTANLGAYFNELKTNYILPTLEYFNGGPIEERDYGSENGSTLYGLVVYHAADCLPEPSVQCYGPTSSP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845    92 YEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIG-QTHRVCLLICNSPPYLLPAVESTTYSGCTTESLV 170
Cdd:pfam11265  81 HKFLQWLDKIDFSGGGGESCALIAEGLATALQCFDDLQKIRENPGlACQRHCILICNSPPYQLPVMESPTYTGKTAEQLA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 81901845   171 QKIGERGIHFSIVSPRKLPALRLLFEKAAPPallEPLQQPADVSQDPRHMVLVRGL 226
Cdd:pfam11265 161 ALMAERNIHLSIISPRKIPALFKLFEKAGPD---LPSSPSKNYAKDPRHLVLLRGF 213
Med25 pfam11232
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ...
 396-545 2.28e-79

Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear.


:

Pssm-ID: 463243  Cd Length: 154  Bit Score: 250.73  E-value: 2.28e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   396 SNKLLAWSGVLEWQEKPKpasvDANTKLTRSLPCQV--YVNHGE-NLKTEQWPQKLIMQLIPQQLLTTLG-PLFRNSRMV 471
Cdd:pfam11232   1 SQRELIWSGVLEWQEKMS----DQNPKITRTLPCQVsnSVKNGEpELKAEKWPQKLIMQLMPKTLLGNIGgALLRNSRVV 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81901845   472 QFHFTNKDLESLKGLYRIMGNGFAGCVHF---PHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHK 545
Cdd:pfam11232  77 VFHFTPTDLEALKSLYRVMSNGFAGCVHFpgiPANPQCDIKVLMLLYSPKKNAFMGLIPNDQAAFVNRLRQVIKKQK 153
Med25_NR-box pfam11244
Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the ...
 657-745 1.40e-37

Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR.


:

Pssm-ID: 463246 [Multi-domain]  Cd Length: 89  Bit Score: 135.17  E-value: 1.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   657 TGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVM 736
Cdd:pfam11244   1 TSVPQTQQPLHHMQQAAQGMLPHQHQAPGQQQLGQTLMHQAPAQSWGAQLPPRAPLPGQMLLSGGPRGPVPQPGLAPSVM 80


                  ....*....
gi 81901845   737 EDDILMDLI 745
Cdd:pfam11244  81 EDDILMDLI 89
Med25_SD1 super family cl25802
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is ...
 228-383 3.80e-29

Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear.


The actual alignment was detected with superfamily member pfam11235:

Pssm-ID: 463244 [Multi-domain]  Cd Length: 157  Bit Score: 113.72  E-value: 3.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   228 LPVGGSSTSGSLQTKQAVPLPPAPASAATLSAAPPQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKSQKAGLGPRFSPIN 307
Cdd:pfam11235   1 LPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPIT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81901845   308 PLQQAAPGVGPPFSQAPAPPLAP-VPPGAPKPPPASQPSLVSTVAPGPVLAAPAQPGAPSLAGTVTPGGVNGPSAAQ 383
Cdd:pfam11235  81 PLQQAAPGVGPPFSQAPAPQLPPgPPGAPKPVPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQ 157
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 561-729 1.60e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.69  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   561 QQAPPVL---GPILEEQARPPQNLLQLRAPQPQPqgavgaSAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQ 637
Cdd:pfam03154 168 QTQPPVLqaqSGAASPPSPPPPGTTQAATAGPTP------SAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   638 NPGANPQLRSLLLNPAPPQTGVPP-PQASLH---------------HLQPPGAPTLLPPHQSMGQPQ--LGPQLLHPPPA 699
Cdd:pfam03154 242 LPSPHPPLQPMTQPPPPSQVSPQPlPQPSLHgqmppmphslqtgpsHMQHPVPPQPFPLTPQSSQSQvpPGPSPAAPGQS 321

                         170       180       190
                  ....*....|....*....|....*....|
gi 81901845   700 QSWPTQLPQRAPLPGQMLLSGGPRGPVPQP 729
Cdd:pfam03154 322 QQRIHTPPSQSQLQSQQPPREQPLPPAPLS 351
 
Name Accession Description Interval E-value
Med25_VWA pfam11265
Mediator complex subunit 25 von Willebrand factor type A; The overall function of the ...
 12-226 3.40e-119

Mediator complex subunit 25 von Willebrand factor type A; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex.


Pssm-ID: 463253  Cd Length: 213  Bit Score: 356.61  E-value: 3.40e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845    12 GGLVADVVFVIEGTANLGPYFEELRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSA 91
Cdd:pfam11265   1 SSVVADVVFVVEGTANLGAYFNELKTNYILPTLEYFNGGPIEERDYGSENGSTLYGLVVYHAADCLPEPSVQCYGPTSSP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845    92 YEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIG-QTHRVCLLICNSPPYLLPAVESTTYSGCTTESLV 170
Cdd:pfam11265  81 HKFLQWLDKIDFSGGGGESCALIAEGLATALQCFDDLQKIRENPGlACQRHCILICNSPPYQLPVMESPTYTGKTAEQLA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 81901845   171 QKIGERGIHFSIVSPRKLPALRLLFEKAAPPallEPLQQPADVSQDPRHMVLVRGL 226
Cdd:pfam11265 161 ALMAERNIHLSIISPRKIPALFKLFEKAGPD---LPSSPSKNYAKDPRHLVLLRGF 213
Med25 pfam11232
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ...
 396-545 2.28e-79

Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear.


Pssm-ID: 463243  Cd Length: 154  Bit Score: 250.73  E-value: 2.28e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   396 SNKLLAWSGVLEWQEKPKpasvDANTKLTRSLPCQV--YVNHGE-NLKTEQWPQKLIMQLIPQQLLTTLG-PLFRNSRMV 471
Cdd:pfam11232   1 SQRELIWSGVLEWQEKMS----DQNPKITRTLPCQVsnSVKNGEpELKAEKWPQKLIMQLMPKTLLGNIGgALLRNSRVV 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81901845   472 QFHFTNKDLESLKGLYRIMGNGFAGCVHF---PHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHK 545
Cdd:pfam11232  77 VFHFTPTDLEALKSLYRVMSNGFAGCVHFpgiPANPQCDIKVLMLLYSPKKNAFMGLIPNDQAAFVNRLRQVIKKQK 153
Med25_NR-box pfam11244
Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the ...
 657-745 1.40e-37

Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR.


Pssm-ID: 463246 [Multi-domain]  Cd Length: 89  Bit Score: 135.17  E-value: 1.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   657 TGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVM 736
Cdd:pfam11244   1 TSVPQTQQPLHHMQQAAQGMLPHQHQAPGQQQLGQTLMHQAPAQSWGAQLPPRAPLPGQMLLSGGPRGPVPQPGLAPSVM 80


                  ....*....
gi 81901845   737 EDDILMDLI 745
Cdd:pfam11244  81 EDDILMDLI 89
Med25_SD1 pfam11235
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is ...
 228-383 3.80e-29

Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear.


Pssm-ID: 463244 [Multi-domain]  Cd Length: 157  Bit Score: 113.72  E-value: 3.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   228 LPVGGSSTSGSLQTKQAVPLPPAPASAATLSAAPPQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKSQKAGLGPRFSPIN 307
Cdd:pfam11235   1 LPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPIT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81901845   308 PLQQAAPGVGPPFSQAPAPPLAP-VPPGAPKPPPASQPSLVSTVAPGPVLAAPAQPGAPSLAGTVTPGGVNGPSAAQ 383
Cdd:pfam11235  81 PLQQAAPGVGPPFSQAPAPQLPPgPPGAPKPVPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQ 157
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 561-729 1.60e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.69  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   561 QQAPPVL---GPILEEQARPPQNLLQLRAPQPQPqgavgaSAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQ 637
Cdd:pfam03154 168 QTQPPVLqaqSGAASPPSPPPPGTTQAATAGPTP------SAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   638 NPGANPQLRSLLLNPAPPQTGVPP-PQASLH---------------HLQPPGAPTLLPPHQSMGQPQ--LGPQLLHPPPA 699
Cdd:pfam03154 242 LPSPHPPLQPMTQPPPPSQVSPQPlPQPSLHgqmppmphslqtgpsHMQHPVPPQPFPLTPQSSQSQvpPGPSPAAPGQS 321

                         170       180       190
                  ....*....|....*....|....*....|
gi 81901845   700 QSWPTQLPQRAPLPGQMLLSGGPRGPVPQP 729
Cdd:pfam03154 322 QQRIHTPPSQSQLQSQQPPREQPLPPAPLS 351
PHA03378 PHA03378
EBNA-3B; Provisional
 652-737 1.69e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.06  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845  652 PAPPQTGVPPPQASLHHLQPP-GAPTLLPPHQS----MGQPQLGPQLLHPP---PAQSWPTQLPQRAPLPGQMllsggPR 723
Cdd:PHA03378 717 PAAATGRARPPAAAPGRARPPaAAPGRARPPAAapgrARPPAAAPGRARPPaaaPGAPTPQPPPQAPPAPQQR-----PR 791

                         90
                 ....*....|....*..
gi 81901845  724 G---PVPQPGLQPSVME 737
Cdd:PHA03378 792 GaptPQPPPQAGPTSMQ 808
PHA03247 PHA03247
large tegument protein UL36; Provisional
 560-733 4.83e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 4.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   560 AQQAPPVLGPILEEQARPPqnllqLRAPQPQPQGAVGASAATGQP-QPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQN 638
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPP-----PPPGPPPPSLPLGGSVAPGGDvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTE 2896

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   639 PGANPQLRSLLLN----PAPPQTGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPG 714
Cdd:PHA03247 2897 SFALPPDQPERPPqpqaPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR 2976

                         170
                  ....*....|....*....
gi 81901845   715 QMLLSGGPRGPVPQPGLQP 733
Cdd:PHA03247 2977 FRVPQPAPSREAPASSTPP 2995
 
Name Accession Description Interval E-value
Med25_VWA pfam11265
Mediator complex subunit 25 von Willebrand factor type A; The overall function of the ...
 12-226 3.40e-119

Mediator complex subunit 25 von Willebrand factor type A; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex.


Pssm-ID: 463253  Cd Length: 213  Bit Score: 356.61  E-value: 3.40e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845    12 GGLVADVVFVIEGTANLGPYFEELRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSA 91
Cdd:pfam11265   1 SSVVADVVFVVEGTANLGAYFNELKTNYILPTLEYFNGGPIEERDYGSENGSTLYGLVVYHAADCLPEPSVQCYGPTSSP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845    92 YEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIG-QTHRVCLLICNSPPYLLPAVESTTYSGCTTESLV 170
Cdd:pfam11265  81 HKFLQWLDKIDFSGGGGESCALIAEGLATALQCFDDLQKIRENPGlACQRHCILICNSPPYQLPVMESPTYTGKTAEQLA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 81901845   171 QKIGERGIHFSIVSPRKLPALRLLFEKAAPPallEPLQQPADVSQDPRHMVLVRGL 226
Cdd:pfam11265 161 ALMAERNIHLSIISPRKIPALFKLFEKAGPD---LPSSPSKNYAKDPRHLVLLRGF 213
Med25 pfam11232
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ...
 396-545 2.28e-79

Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear.


Pssm-ID: 463243  Cd Length: 154  Bit Score: 250.73  E-value: 2.28e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   396 SNKLLAWSGVLEWQEKPKpasvDANTKLTRSLPCQV--YVNHGE-NLKTEQWPQKLIMQLIPQQLLTTLG-PLFRNSRMV 471
Cdd:pfam11232   1 SQRELIWSGVLEWQEKMS----DQNPKITRTLPCQVsnSVKNGEpELKAEKWPQKLIMQLMPKTLLGNIGgALLRNSRVV 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81901845   472 QFHFTNKDLESLKGLYRIMGNGFAGCVHF---PHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHK 545
Cdd:pfam11232  77 VFHFTPTDLEALKSLYRVMSNGFAGCVHFpgiPANPQCDIKVLMLLYSPKKNAFMGLIPNDQAAFVNRLRQVIKKQK 153
Med25_NR-box pfam11244
Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the ...
 657-745 1.40e-37

Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR.


Pssm-ID: 463246 [Multi-domain]  Cd Length: 89  Bit Score: 135.17  E-value: 1.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   657 TGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVM 736
Cdd:pfam11244   1 TSVPQTQQPLHHMQQAAQGMLPHQHQAPGQQQLGQTLMHQAPAQSWGAQLPPRAPLPGQMLLSGGPRGPVPQPGLAPSVM 80


                  ....*....
gi 81901845   737 EDDILMDLI 745
Cdd:pfam11244  81 EDDILMDLI 89
Med25_SD1 pfam11235
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is ...
 228-383 3.80e-29

Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear.


Pssm-ID: 463244 [Multi-domain]  Cd Length: 157  Bit Score: 113.72  E-value: 3.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   228 LPVGGSSTSGSLQTKQAVPLPPAPASAATLSAAPPQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKSQKAGLGPRFSPIN 307
Cdd:pfam11235   1 LPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPIT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81901845   308 PLQQAAPGVGPPFSQAPAPPLAP-VPPGAPKPPPASQPSLVSTVAPGPVLAAPAQPGAPSLAGTVTPGGVNGPSAAQ 383
Cdd:pfam11235  81 PLQQAAPGVGPPFSQAPAPQLPPgPPGAPKPVPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQ 157
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 586-732 2.23e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.27  E-value: 2.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   586 APQPQPQGAVGASAATGQP-------------QPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQNPGANPQLRSLLLNP 652
Cdd:pfam09770 174 APAPQPAAQPASLPAPSRKmmsleeveaamraQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQP 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   653 APPQTGVPPPQAslhhLQPPGAPTLlPPHQSMGQPQLGPQLLHPPPAQSWPTQL---PQRAPLPGQMLLSGGPRGPVPQP 729
Cdd:pfam09770 254 QQHPGQGHPVTI----LQRPQSPQP-DPAQPSIQPQAQQFHQQPPPVPVQPTQIlqnPNRLSAARVGYPQNPQPGVQPAP 328


                  ...
gi 81901845   730 GLQ 732
Cdd:pfam09770 329 AHQ 331
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 561-729 1.60e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.69  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   561 QQAPPVL---GPILEEQARPPQNLLQLRAPQPQPqgavgaSAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQ 637
Cdd:pfam03154 168 QTQPPVLqaqSGAASPPSPPPPGTTQAATAGPTP------SAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   638 NPGANPQLRSLLLNPAPPQTGVPP-PQASLH---------------HLQPPGAPTLLPPHQSMGQPQ--LGPQLLHPPPA 699
Cdd:pfam03154 242 LPSPHPPLQPMTQPPPPSQVSPQPlPQPSLHgqmppmphslqtgpsHMQHPVPPQPFPLTPQSSQSQvpPGPSPAAPGQS 321

                         170       180       190
                  ....*....|....*....|....*....|
gi 81901845   700 QSWPTQLPQRAPLPGQMLLSGGPRGPVPQP 729
Cdd:pfam03154 322 QQRIHTPPSQSQLQSQQPPREQPLPPAPLS 351
PHA03378 PHA03378
EBNA-3B; Provisional
 652-737 1.69e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.06  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845  652 PAPPQTGVPPPQASLHHLQPP-GAPTLLPPHQS----MGQPQLGPQLLHPP---PAQSWPTQLPQRAPLPGQMllsggPR 723
Cdd:PHA03378 717 PAAATGRARPPAAAPGRARPPaAAPGRARPPAAapgrARPPAAAPGRARPPaaaPGAPTPQPPPQAPPAPQQR-----PR 791

                         90
                 ....*....|....*..
gi 81901845  724 G---PVPQPGLQPSVME 737
Cdd:PHA03378 792 GaptPQPPPQAGPTSMQ 808
VWA pfam00092
von Willebrand factor type A domain;
17-135 2.09e-04

von Willebrand factor type A domain;


Pssm-ID: 459670 [Multi-domain]  Cd Length: 174  Bit Score: 42.65  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845    17 DVVFVIEGTANLGPY-FEELRKhYLLPAIEYFNGGPPaetdfggdygGTQYSLVVFNtvdcapeSYVQCHAPTSSAY--- 92
Cdd:pfam00092   1 DIVFLLDGSGSIGGDnFEKVKE-FLKKLVESLDIGPD----------GTRVGLVQYS-------SDVRTEFPLNDYSske 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 81901845    93 EFVTWLDGIKFMGGGGescSLIAEGLSTALQ-LFDDFKKMREQI 135
Cdd:pfam00092  63 ELLSAVDNLRYLGGGT---TNTGKALKYALEnLFSSAAGARPGA 103
PHA03247 PHA03247
large tegument protein UL36; Provisional
 560-733 4.83e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 4.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   560 AQQAPPVLGPILEEQARPPqnllqLRAPQPQPQGAVGASAATGQP-QPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQN 638
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPP-----PPPGPPPPSLPLGGSVAPGGDvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTE 2896

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   639 PGANPQLRSLLLN----PAPPQTGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPG 714
Cdd:PHA03247 2897 SFALPPDQPERPPqpqaPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR 2976

                         170
                  ....*....|....*....
gi 81901845   715 QMLLSGGPRGPVPQPGLQP 733
Cdd:PHA03247 2977 FRVPQPAPSREAPASSTPP 2995
PHA03247 PHA03247
large tegument protein UL36; Provisional
 586-734 1.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   586 APQPQPQGAVGASAATGQPQPQGATQAPTGAPQGPPgaapGPPPSGPILRPQNPGANPQLRslllnpAPPQTGVPPPQAS 665
Cdd:PHA03247 2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG----PPPPSLPLGGSVAPGGDVRRR------PPSRSPAAKPAAP 2878

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81901845   666 LHhlqPP----GAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGQMllSGGPRGPVPQPGLQPS 734
Cdd:PHA03247 2879 AR---PPvrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ--PPPPPPPRPQPPLAPT 2946
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 560-735 1.28e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845  560 AQQAPPVLGPILEEQARPPQNLLQLRAPQPQpqgAVGASAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQNP 639
Cdd:PRK07764 586 AVVGPAPGAAGGEGPPAPASSGPPEEAARPA---APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845  640 GANPQLRSLLLNPAPPQTGVPPPQASLHHL---QPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRA---PLP 713
Cdd:PRK07764 663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAApagAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADdpvPLP 742

                        170       180
                 ....*....|....*....|..
gi 81901845  714 GQMLLSGGPRGPVPQPGLQPSV 735
Cdd:PRK07764 743 PEPDDPPDPAGAPAQPPPPPAP 764
PHA03378 PHA03378
EBNA-3B; Provisional
 575-730 1.75e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.98  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845  575 ARPPQnllqlRAPQPQPQGAvgasAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPqnPGANPqlrSLLLNPAP 654
Cdd:PHA03378 694 MQPPP-----RAPTPMRPPA----APPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARP--PAAAP---GRARPPAA 759

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81901845  655 PQTGVPPPQASlhhlqpPGAPTLLPPhqsmgqPQLGPQLLHPPPAQSWPTQLPQRAPLPGQMLlsggPRGPVPQPG 730
Cdd:PHA03378 760 APGRARPPAAA------PGAPTPQPP------PQAPPAPQQRPRGAPTPQPPPQAGPTSMQLM----PRAAPGQQG 819
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 643-733 3.75e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 3.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   643 PQLRSLLLNPAPPQTGVPPPQASLHHLQPPGAPTLLP-PHQSMGQPQLGPQLLHPPPA--QSWPTQLPQRAPLPGQMLLS 719
Cdd:pfam03154 172 PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPqGSPATSQPPNQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQP 251

                          90
                  ....*....|....
gi 81901845   720 GGPRGPVPQPGLQP 733
Cdd:pfam03154 252 MTQPPPPSQVSPQP 265
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 587-735 4.52e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 4.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   587 PQPQPQGAVGASAATGQP--QPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQNPGANPQLR---SLLLNPAPPQ--TGV 659
Cdd:pfam03154 311 PGPSPAAPGQSQQRIHTPpsQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHkhpPHLSGPSPFQmnSNL 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   660 PPPQA-----SLHHLQPPGAP----TLLPPHQSMGQPQLGPQLL-----HPPPAQSWPT-----QLPQRAPLPGQMLLSG 720
Cdd:pfam03154 391 PPPPAlkplsSLSTHHPPSAHppplQLMPQSQQLPPPPAQPPVLtqsqsLPPPAASHPPtsglhQVPSQSPFPQHPFVPG 470

                         170
                  ....*....|....*
gi 81901845   721 GPRGPVPQPGLQPSV 735
Cdd:pfam03154 471 GPPPITPPSGPPTST 485
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
557-715 6.17e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 39.76  E-value: 6.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845  557 GMGAQQAppvLGPILEEQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGATQAPTgapqgppgaapgpppsgpilRP 636
Cdd:PRK14971 372 GRGPKQH---IKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPT--------------------VS 428

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845  637 QNPGAnpqlrslllnPAPpqtgVPPPQASLHHLQPPGAPTLLPPhQSMGQPQLGPQLLHP-PPAQSWPTQLPQRAPLPGQ 715
Cdd:PRK14971 429 VDPPA----------AVP----VNPPSTAPQAVRPAQFKEEKKI-PVSKVSSLGPSTLRPiQEKAEQATGNIKEAPTGTQ 493
PHA03247 PHA03247
large tegument protein UL36; Provisional
 564-733 7.12e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 7.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   564 PPVLGPILEEQARPPQNLlqlrapQPQPQGAVGASAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQNPGANP 643
Cdd:PHA03247 2720 PLPPGPAAARQASPALPA------APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSE 2793

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81901845   644 QLRSLLLNPAP-------------------PQTGVPPPQASLhHLQPPGAPTLLPPHQSMG----------------QPQ 688
Cdd:PHA03247 2794 SRESLPSPWDPadppaavlapaaalppaasPAGPLPPPTSAQ-PTAPPPPPGPPPPSLPLGgsvapggdvrrrppsrSPA 2872

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 81901845   689 LGPQLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQP 733
Cdd:PHA03247 2873 AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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