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Conserved domains on  [gi|81915176|sp|Q8VDL9|]
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RecName: Full=Zinc finger protein GLIS2; AltName: Full=GLI-similar 2; AltName: Full=Neuronal Krueppel-like protein; AltName: Full=Zinc finger protein GLI5

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-327 2.25e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 2.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176 233 KPHRCPTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSlrK 312
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS--S 109

                        90
                ....*....|....*
gi 81915176 313 HIKAHGHFVSHEQQE 327
Cdd:COG5048 110 LSSSSSNSNDNNLLS 124
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-327 2.25e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 2.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176 233 KPHRCPTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSlrK 312
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS--S 109

                        90
                ....*....|....*
gi 81915176 313 HIKAHGHFVSHEQQE 327
Cdd:COG5048 110 LSSSSSNSNDNNLLS 124
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-246 2.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.81e-05
                          10        20
                  ....*....|....*....|..
gi 81915176   225 HIRTHTNEKPHRCPTCNKSFSR 246
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-327 2.25e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 2.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176 233 KPHRCPTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSlrK 312
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS--S 109

                        90
                ....*....|....*
gi 81915176 313 HIKAHGHFVSHEQQE 327
Cdd:COG5048 110 LSSSSSNSNDNNLLS 124
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-308 4.15e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176 233 KPHRCPTCNKSFSRLENLKIHNRS--HTGE--KPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPS 308
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 259-319 1.16e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.87  E-value: 1.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176 259 GEKPYVCPYEGCNKRYSNSS-------------------DRFKHTRTHYVDKPYYCkmPGCHKRYTDPSSLRKHIKaHGH 319
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNglkyhmlhghqnqklhenpSPEKMNIFSAKDKPYRC--EVCDKRYKNLNGLKYHRK-HSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
59-317 5.29e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 5.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176  59 FLLNPKFPEKVDGRFSAAPLVDL--SLSPPSGLDSPNGSSSLSPE-CQGNGDLPPLptavDFQPLRYLDGVPSSFQFfLP 135
Cdd:COG5048 183 NLSLLISSNVSTSIPSSSENSPLssSYSIPSSSSDQNLENSSSSLpLTTNSQLSPK----SLLSQSPSSLSSSDSSS-SA 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176 136 LGSGGALHLPASSFLPPPKDKCLSPELplAKQLVCRWAKCNQLFELLQDLVDHVNDHHVKPEQDARYCCHWEGCarhGRG 215
Cdd:COG5048 258 SESPRSSLPTASSQSSSPNESDSSSEK--GFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLC---GKL 332

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176 216 FNARYKMLIHIRTHTNEKPHRCPT--CNKSFSRLENLK-----IHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHY 288
Cdd:COG5048 333 FSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHL 412

                       250       260
                ....*....|....*....|....*....
gi 81915176 289 VDKPYYCKMPGCHKRYTDPSSLRKHIKAH 317
Cdd:COG5048 413 SFRPYNCKNPPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-246 2.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.81e-05
                          10        20
                  ....*....|....*....|..
gi 81915176   225 HIRTHTNEKPHRCPTCNKSFSR 246
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-304 2.97e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176 177 QLFELLQDLVDHVNDHHVKPEQDARYCCHWEGCARHgrgFNARYKMLIHIRTHTNEKPHRC--PTCNKSFSRLENLKIHN 254
Cdd:COG5048   7 QSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDS---FSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHL 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 81915176 255 RSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRY 304
Cdd:COG5048  84 RTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 235-257 3.73e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 3.73e-04
                          10        20
                  ....*....|....*....|...
gi 81915176   235 HRCPTCNKSFSRLENLKIHNRSH 257
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-276 1.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....*...
gi 81915176   249 NLKIHNRSHTGEKPYVCPYegCNKRYSN 276
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
235-257 3.59e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 34.91  E-value: 3.59e-03
                          10        20
                  ....*....|....*....|...
gi 81915176   235 HRCPTCNKSFSRLENLKIHNRSH 257
Cdd:pfam13912   2 HECSECGKSFPSYQALGGHKKSH 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-283 6.68e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 6.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176  93 NGSSSLSPECQGNGDLPPLPTAVDFQPLRYLDGVPSSFQFFLPLGSGGALHLPASSFLPPPKDKCLSPELPLAKQLVCRW 172
Cdd:COG5048 247 SLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPY 326

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81915176 173 AKCNQLFELLQDLVDHVNDH-------------------------------HVKPEQDARYCCHWEGCARHgrgFNARYK 221
Cdd:COG5048 327 SLCGKLFSRNDALKRHILLHtsispakekllnssskfspllnneppqslqqYKDLKNDKKSETLSNSCIRN---FKRDSN 403

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81915176 222 MLIHIRTHTNEKPH--RCPTCNKSFSRLENLKIHNRSHTGEKPYVCpyegCNKRYSNSSDRFKH 283
Cdd:COG5048 404 LSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC----SILKSFRRDLDLSN 463
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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