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Conserved domains on  [gi|74730987|sp|Q8WXA2|]
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RecName: Full=Prostate and testis expressed protein 1; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_PATE1 cd23577
extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and ...
 45-126 1.09e-53

extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and similar proteins; PATE1 is a novel sperm-associated protein generally expressed in male genital tract and related to sperm development, maturation and fertilization. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467107  Cd Length: 82  Bit Score: 163.01  E-value: 1.09e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730987  45 IVQCRMCHLQFPGEKCSRGRGICTATTEEACMVGRMFKRDGNPWLTFMGCLKNCADVKGIRWSVYLVNFRCCRSHDLCNE 124
Cdd:cd23577   1 IVQCRMCHLQFPGEKCSRGRGICTATTEEACVVGRIFKKDGTPWLTFMGCLKNCANVKKIKWSVYLVNFRCCRGYDLCNE 80


                ..
gi 74730987 125 DL 126
Cdd:cd23577  81 NL 82
 
Name Accession Description Interval E-value
TFP_LU_ECD_PATE1 cd23577
extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and ...
 45-126 1.09e-53

extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and similar proteins; PATE1 is a novel sperm-associated protein generally expressed in male genital tract and related to sperm development, maturation and fertilization. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467107  Cd Length: 82  Bit Score: 163.01  E-value: 1.09e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730987  45 IVQCRMCHLQFPGEKCSRGRGICTATTEEACMVGRMFKRDGNPWLTFMGCLKNCADVKGIRWSVYLVNFRCCRSHDLCNE 124
Cdd:cd23577   1 IVQCRMCHLQFPGEKCSRGRGICTATTEEACVVGRIFKKDGTPWLTFMGCLKNCANVKKIKWSVYLVNFRCCRGYDLCNE 80


                ..
gi 74730987 125 DL 126
Cdd:cd23577  81 NL 82
 
Name Accession Description Interval E-value
TFP_LU_ECD_PATE1 cd23577
extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and ...
 45-126 1.09e-53

extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and similar proteins; PATE1 is a novel sperm-associated protein generally expressed in male genital tract and related to sperm development, maturation and fertilization. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467107  Cd Length: 82  Bit Score: 163.01  E-value: 1.09e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730987  45 IVQCRMCHLQFPGEKCSRGRGICTATTEEACMVGRMFKRDGNPWLTFMGCLKNCADVKGIRWSVYLVNFRCCRSHDLCNE 124
Cdd:cd23577   1 IVQCRMCHLQFPGEKCSRGRGICTATTEEACVVGRIFKKDGTPWLTFMGCLKNCANVKKIKWSVYLVNFRCCRGYDLCNE 80


                ..
gi 74730987 125 DL 126
Cdd:cd23577  81 NL 82
TFP_LU_ECD_PATE3 cd23579
extracellular domain (ECD) found in prostate and testis expressed protein 3 (PATE3) and ...
 46-124 2.40e-10

extracellular domain (ECD) found in prostate and testis expressed protein 3 (PATE3) and similar proteins; PATE3 (also called acrosomal vesicle protein HEL-127, or PATE-like protein DJ (PATE-DJ)) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE3 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467109  Cd Length: 80  Bit Score: 52.82  E-value: 2.40e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74730987  46 VQCRMCHLQFPGEKCSRGRGICTATTEEACMVGRMFKRDgNPWLTFMGCLKNCADvKGIRWSVYLVNFRCCRShDLCNE 124
Cdd:cd23579   5 LKCITCHLRTVSDRCRRGFGTCTAQKDESCMRLRIYQGD-TLQLSYMVCQKFCRD-LTYHFNNRTYVHTCCNK-DYCNF 80
TFP_LU_ECD_mPATE6_like cd23581
extracellular domain (ECD) found in Mus musculus prostate and testis expressed protein 6 ...
 46-123 7.13e-06

extracellular domain (ECD) found in Mus musculus prostate and testis expressed protein 6 (PATE6) and similar proteins; The family includes Mus musculus PATE6 and PATE7. PATE6 (also called called prostate and testis expressed 6, or PATE-like protein C) acts as nicotinic acetylcholine receptor (nAChR) regulator. The biological function of PATE7 (also called called prostate and testis expressed 7) remains unclear. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467111  Cd Length: 82  Bit Score: 41.29  E-value: 7.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730987  46 VQCRMChLQFPGEKCSRGRGICTATTEEACMVGRMFKRDG--NPWLTFMGCLKNCADVKGIRWSvYLVNFRCCRSHDLCN 123
Cdd:cd23581   4 LQCNQC-LSYKDGECVHGKQTCTAKPGESCMIRRIFSASEsvTINSAERGCTKNCTSTEDISGD-YTVITTCCSDFDFCN 81
TFP_LU_ECD_Ly6G5b cd23544
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) ...
 45-124 9.09e-06

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) and similar proteins; Ly6G5b is a glycosylated, potentially secreted protein which could act as ligand for other cell-surface receptors and could thus potentially have a role in cell signaling. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467074  Cd Length: 82  Bit Score: 40.85  E-value: 9.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730987  45 IVQCRMCHLQFPGEKCSRGRGICTATTEEACMVGRMFkRDGNPWLTFMGCLKN----CADVKGIRWSVYLVNFRCCRsHD 120
Cdd:cd23544   1 ARRCHLCLLEDPSIGCISGSEKCTPSSGEPCMTITIY-YEGKVRFLVRGCGQHssyrCGERKKTYVSGYWYNARCCQ-YD 78


                ....
gi 74730987 121 LCNE 124
Cdd:cd23544  79 YCNS 82
TFP_LU_ECD_C9orf57 cd23610
extracellular domain (ECD) found in Homo sapiens uncharacterized protein C9orf57 and similar ...
 48-123 1.74e-04

extracellular domain (ECD) found in Homo sapiens uncharacterized protein C9orf57 and similar proteins; C9orf57 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467130  Cd Length: 83  Bit Score: 37.49  E-value: 1.74e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74730987  48 CRMCHLQFPGEKCSRGRGICTATTEEACMVGRMFKRdGNPWLTFMGCLKN---CADVKGIRWSVyLVNFRCCRSHdLCN 123
Cdd:cd23610   7 CRMCNLSKPFHGCTLGGGTCLAKPGQYCKTERHIKG-GIEWFSIKGCTKNseeCGSTKEVGYSG-RVTTTCCNSH-MCN 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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