|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
1-388 |
2.25e-146 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 420.45 E-value: 2.25e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 1 MPALTQHSTSITLFRISAAMFLNYLTIGIPLVMLPLYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTV 80
Cdd:PRK05122 5 EPALSGLRLTLRIVSIVMFTFISYLTIGLPLAVLPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 81 ITGQFYCAASGLLMLVSLIAHPVPLLAWAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIG 160
Cdd:PRK05122 85 VFGLCGCALSGLLYLLAGLLAAWPVLSLLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALAIG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 161 APLGLSLYARAGLALPALLVVLLPIIASGVIYGIPGNIPTARPRVPVLRVVGLVWRPGTGLVLQGIGFATLSAFTALWFN 240
Cdd:PRK05122 165 APLGVLLYHWGGLAGLGLLIMLLALLGLLLARPRPAVPPVKGERLPFRRVLGRVWPYGMGLALASIGFGTIATFITLYYA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 241 ERHWDNTGFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSLG 320
Cdd:PRK05122 245 ARGWDGAALALTLFGVAFVGARLLFGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALG 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27734608 321 VEVVRRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVFLLAAACALLGAAVVHLLLRQH 388
Cdd:PRK05122 325 VEAVKRVPPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLALTWLLYRRA 392
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
1-388 |
2.63e-122 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 358.99 E-value: 2.63e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 1 MPALTQH----STSITLFRISAAMFLNYLTIGIPLVMLPLYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGG 76
Cdd:PRK12382 1 MTAVSQTetrsSANFSLFRIAFAVFLTYMTVGLPLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 77 RRTVITGQFYCAASGLLMLVSLIAHPVPLLAWAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGA 156
Cdd:PRK12382 81 KRSALQGMLACGLAGLAYLLAAILPVSAPFKFALLVVGRLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 157 LAIGAPLGLSLYARAGLALPALLVVLLPIIASGVIYGIPGNIPTARPRVPVLRVVGLVWRPGTGLVLQGIGFATLSAFTA 236
Cdd:PRK12382 161 LAAGAPLGLLLHSHFGFAALALTTMVLPLLAWAFNGTVRKVPAHAGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFVS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 237 LWFNERHWDNTGFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMF 316
Cdd:PRK12382 241 LYFASKGWAMAGFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIF 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27734608 317 PSLGVEVVRRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVFLLAAACALLGAAVVHLLLRQH 388
Cdd:PRK12382 321 PALGVEVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIVTILSFRRG 392
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
16-385 |
1.20e-76 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 241.34 E-value: 1.20e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 16 ISAAMFLNYLTIGIPLVMLPLYVQQqLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGLLML 95
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 96 VSLiahpvpllAWAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYARAGLAL 175
Cdd:cd17489 80 LAT--------SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 176 PALLVVLLPIIASGVIYGIPGNIPTA------RPRVPVLRVVGLVWRPGTGLVLQGIGFATLSAFTALWFNERHWDNTGF 249
Cdd:cd17489 152 LFIVAAVLALLALLLVFLVKDPPPVAaeeaeaGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 250 AMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSLGVEVVRRVPP 329
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 27734608 330 EIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVFLLAAACALLGAAVVHLLL 385
Cdd:cd17489 312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-367 |
5.16e-30 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 118.83 E-value: 5.16e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 16 ISAAMFLNYLTIGIPLVMLPLYVQQqLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGLLML 95
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 96 VSLIahpvpllaWAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYARAGLAL 175
Cdd:cd17325 80 FATS--------YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 176 PALLVVLLPIIASGVIYGIPGNIPTARPRVPV-----------LRVVGLVWRPGTGLVLQGIGFATLSAFTALWFNERHW 244
Cdd:cd17325 152 PFLVCAALALLALVLALLLLPEPRPPPNKRAVsaarlrsglrlLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 245 DNT---GFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSLGV 321
Cdd:cd17325 232 LSPaqiGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 27734608 322 EVVRRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVF 367
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-346 |
6.44e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 92.73 E-value: 6.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 5 TQHSTSITLFRISAAMFLNYLTIGIPLVMLPLYVQQqLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQ 84
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 85 FYCAASGLLMLVSLiahpvpllAWAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLG 164
Cdd:COG2814 83 LLFALGSLLCALAP--------SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 165 LSLYARAGLALPALLVVLLPIIASGVIY-GIPGNIPTARPR----VPVLRVVGLVWRPGTGLVLQGIGFATLSAFTALWF 239
Cdd:COG2814 155 GLLADLFGWRWVFLVNAVLALLALLLLLrLLPESRPAARARlrgsLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 240 NERHW---DNTGFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMF 316
Cdd:COG2814 235 QEVLGlsaSAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314
|
330 340 350
....*....|....*....|....*....|
gi 27734608 317 PSLGVEVVRRVPPEIRGTALGVWSAFQDLA 346
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
16-349 |
2.76e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 76.30 E-value: 2.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 16 ISAAMFLNYLTIGIPLVMLPLYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGLLML 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 96 VSliahpvplLAWAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYARAGLAL 175
Cdd:pfam07690 81 FA--------SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 176 PALLVVLLPIIASGVIY------GIPGNIPTARPRVPVLRVVGLVWRPG-----TGLVLQGIGFATLSAFTALWFNERHW 244
Cdd:pfam07690 153 AFLILAILSLLAAVLLLlprpppESKRPKPAEEARLSLIVAWKALLRDPvlwllLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 245 DN--TGFAMTLFGIAFIAVRFFCAKFPDRYGG---ATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSL 319
Cdd:pfam07690 233 SAllAGLLLGLGGLLGAIGRLLLGRLSDRLGRrrrLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|
gi 27734608 320 GVEVVRRVPPEIRGTALGVWSAFQDLAYGF 349
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-386 |
2.75e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.20 E-value: 2.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 16 ISAAMFLNYLTIGIPLVMLPlYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGqfyCAASGLLML 95
Cdd:COG2271 15 LFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG---LLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 96 VSLIAHpvpllAWAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYARAGLAL 175
Cdd:COG2271 91 LFGFAT-----SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 176 PAllvvllpiiasgVIYGIPGniptarprvpVLRVVGLVWRPGTGLVLQGIGFATLSAFTALWFNE-RHWDNT--GFAMT 252
Cdd:COG2271 166 AF------------LILGLPG----------LLLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAqaGLLLS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 253 LFGIAFIAVRFFCAKFPDRYG--GATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSLGVEVVRRVPPE 330
Cdd:COG2271 224 LPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKK 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 27734608 331 IRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVFLLAAACALLGAAVVHLLLR 386
Cdd:COG2271 304 ARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-358 |
5.83e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 66.30 E-value: 5.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 16 ISAAMFLNYLTIGIPLVMLPLYvQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGLLML 95
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPAL-LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 96 VSLiahpvpllAWAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYAR--AGL 173
Cdd:cd06174 80 FAP--------SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 174 ALPALLVVLLPIIASGVIYGIPGNIPTARPRVP-------------VLRVVGLVWRPGTGLVLQGIGFATLSAFTALWFN 240
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNeeassksvlkllkRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 241 ERH---WDNTGFAMTLFGIAFIAVRFFCAKFPDRYGG-ATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMF 316
Cdd:cd06174 232 DLGglsVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGrKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 27734608 317 PSLGVEVVRRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLLT 358
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
13-367 |
3.49e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.09 E-value: 3.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 13 LFRISAAMFLNYLTIGIPLVMLPLYVQQQLHlSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQfycAASGL 92
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAD---LLRAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 93 LMLVSLIAHPVPLLAWAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYARAG 172
Cdd:cd06173 77 LAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 173 LALPALLVVLLPIIASGVIYGIPGNIPTARPRVPVLR----VVGLVWRPGTGLVLQGIGFATLSAFTA------------ 236
Cdd:cd06173 157 PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLlrdlREGLRYLRRSPLLRLLLLALALFALLGgaltvllpllak 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 237 --LWFNERHWdntGFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSL 314
Cdd:cd06173 237 evLGGGAAGY---GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGL 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 27734608 315 MFPSLGVEVVRRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVF 367
Cdd:cd06173 314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
13-367 |
4.12e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.70 E-value: 4.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 13 LFRISAAMFLNYLTIGIPLVMLPLYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGL 92
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 93 LMLvslIAHPVPLLAWAIlivgrVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYARAG 172
Cdd:cd17329 81 LLG---FAHSPWLFAIAL-----VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 173 LALPALLVVLLPIIASGVIYGIPGNIPTARPRVPVLRVVGLvwrpgtGLVLQGIGFATLS-AFTALWFNERHWDNT---- 247
Cdd:cd17329 153 RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGY------KIVLRDRAFLLFLlASFLISLIYFQLESTlpvy 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 248 ------------GFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLM 315
Cdd:cd17329 227 vveilglgesllGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLV 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 27734608 316 FPSLGVEVVRRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVF 367
Cdd:cd17329 307 FPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-192 |
1.20e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 13 LFRISAAMFLNYLTIGIPLVMLPLYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGL 92
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 93 LMLVSliahpvplLAWAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYARAG 172
Cdd:cd17325 281 LLPLA--------TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
170 180
....*....|....*....|
gi 27734608 173 LALPALLVVLLPIIASGVIY 192
Cdd:cd17325 353 FATPFLAAAALLLLAAVLFL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-387 |
1.03e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 53.35 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 11 ITLFRISAAMFLNYLTIGIPLVMLPlYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGqfyCAAS 90
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAP-PLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG---LLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 91 GLLMLVSLIAHPVPLLawailIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYAR 170
Cdd:COG2223 81 GIGLLLLALAVSYWLL-----LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 171 AGLALPALLVVLLPIIASGVIYGIPGNIPTARPRVPVLRVVGL--------VWRPGTGLVLQGIGFATLSAFTALWFNER 242
Cdd:COG2223 156 FGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQlealrdprFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 243 H---WDNTGFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVM-WAAPSAGAALIGAAITGCGCSLMFPS 318
Cdd:COG2223 236 FglsAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLaLALGSLWLFLVLFLLLGLALGGGNGA 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 319 LGVEVVRRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIG-YQQVFLLAAACALLGAAVVHLLLRQ 387
Cdd:COG2223 316 VFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-367 |
1.58e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.93 E-value: 1.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 5 TQHSTSITLFRISAAMFLNYLTIGIPLVMLPlYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQ 84
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 85 FYCAASGLLMLVSLiahpvpllAWAILIVGRVLLGIGESFILTGNLTWGMWLaGSTHAGQVISWNGMAtYGALAIGAPLG 164
Cdd:COG0738 81 LLMALGLLLFALAP--------SYPLLLLALFLLGLGLGLLDVAANPYVAAL-GPETAASRLNLLHAF-FSLGALLGPLL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 165 LSLYARAGLALPALLVVLLPIIASGVI------YGIPGNIPTARPRVPVLRVVGLVWRPGtGLVLQGIGFA-------TL 231
Cdd:COG0738 151 GGLLILLGLSLSWHLPYLILAVLLLLLallflrSKLPEIEEEEEEAAGSAASLKSLLKNP-RLLLGGLAIFlyvgaegAI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 232 SAFTALWFNERH---WDNTGFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAIT 308
Cdd:COG0738 230 GDWLPLYLKDVLglsEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 27734608 309 GCGCSLMFPSLGVEVVRRVPPEiRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVF 367
Cdd:COG0738 310 GLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF 367
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
34-342 |
1.88e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 1.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 34 LPLYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGL--LMLVSLIAhpvpllawaiL 111
Cdd:cd17473 22 LPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVagLFLDSLYA----------L 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 112 IVGRVLLGIGESFILTGNLTwgmwLAGSTHAGQ----VISWNGMATYGALAIGAPLGLSLyARAGLALPALLVVLLPIIA 187
Cdd:cd17473 92 LASRALLGIGVAGIMTLATA----LIGDYFEGEerakMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYLLALPVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 188 SGVIYGIPgniPTARPRVPVLRVVGLVWRPGTGLVLQGIGFATLSAFTALW---------FNERHWDN---TGFAMTLFG 255
Cdd:cd17473 167 ILVLLFLP---EPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYvipiqlpflLQERGGGSaalIGLALAIAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 256 IAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSLGVEVVRRVPPEIRGTA 335
Cdd:cd17473 244 LAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRA 323
|
....*..
gi 27734608 336 LGVWSAF 342
Cdd:cd17473 324 MGIVTSA 330
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
248-367 |
2.59e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.95 E-value: 2.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 248 GFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSLGVEVVRRV 327
Cdd:pfam07690 35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWF 114
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 27734608 328 PPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVF 367
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-192 |
7.32e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.55 E-value: 7.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 17 SAAMFLNYLTIGIPLVMLPLYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGLLMLV 96
Cdd:cd17321 174 VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 97 SLIAHPVPLLAWAIlivgrVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYARAGLALP 176
Cdd:cd17321 254 LGADSSVWLLLPGL-----VLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANL 328
|
170
....*....|....*.
gi 27734608 177 ALLVVLLPIIASGVIY 192
Cdd:cd17321 329 GDSGVAALLSAAAAAF 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-364 |
8.86e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.59 E-value: 8.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 12 TLFRISAAMFLNYLTIGIPLVMLPLYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKAD---TSGGRRT--VITGQFY 86
Cdd:COG2211 11 EKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrTRWGRRRpwILIGAIP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 87 CAASGLLMLVSLIAHPVPLLAWAILIVgrVLLGIGESFILTGNLTWGMWLAGSTHA-GQVISWNGMATYGALAIGAPLGL 165
Cdd:COG2211 91 LALSFVLLFTAPDLSPTGKLIYALVTY--LLLGLAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 166 SLYARAGLALPALLVVLLPIIAS-------GVIYGIPGNIPTARPRVPVLRVVGLVWRPGTGLVLQGIGFATLSAFTALW 238
Cdd:COG2211 169 PLVAAFGGDAALGYRLTALIFAVlgllaflLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 239 -----FNERHWDN----TGFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAP--SAGAALIGAAI 307
Cdd:COG2211 249 alllyYFKYVLGLsaalVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAAL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27734608 308 TGCGCSLMFPSLGVEVVRRVPPE-------IRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQ 364
Cdd:COG2211 329 AGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALFGYV 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
248-386 |
1.38e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 248 GFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSLGVEVVRRV 327
Cdd:COG2814 48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLV 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 27734608 328 PPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVFLLAAACALLGAAVVHLLLR 386
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
14-367 |
1.68e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.45 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 14 FRISAAMFLNYLTIGIPLvmLPLYVQQqLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGLL 93
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPF--LSPYAES-LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 94 MLVslIAHPVpllaWAILIvGRVLLGIGESFILTGNLTWGMWLAGStHAGQVISWNGMATYGALAIGAPLGLSLYARAGL 173
Cdd:cd17490 78 IMI--LFPSP----WGLLI-ARFLSGIAAATWVSFTVLYASYFPPD-EAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGM 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 174 ALPALLVVLLPIIASGVIYGIPGNIPTARPRVPVLRVVGLVWR-------PGTGLVLQGIGFATLSAFTALWFNERHWDN 246
Cdd:cd17490 150 RAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKELLSVLKdkkllffSLLAILQQMITFSTTFGFTPLIAKQLGASS 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 247 T-----GFAMTLFGIAFIavRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSLGV 321
Cdd:cd17490 230 FqlgllSIIYLLPNALAS--LLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMS 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 27734608 322 EVVRRVPPEIRGTALGVWSAFQDLAYgFTGPI-AGLLTPFIGYQQVF 367
Cdd:cd17490 308 LSIEGVPAEQRSTAMGFFQAIYALGM-FLGPVlVGIISEAFGLQTGF 353
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
16-367 |
6.00e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.49 E-value: 6.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 16 ISAAMFLNYLTIGIPLVMLPLYVQQQ--LHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGLL 93
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 94 MLVSLiahpvpllAWAILIVGRVLLGIGESfiltGNLTWGMWLAGSTHA---GQVISWNGMATYGALAIGAPLGLSLYAR 170
Cdd:cd17330 81 LGLSR--------NLWLLFLARFLDGLTGG----NVSVAQAYIADITDEeerAKAFGIISAAFGLGFILGPALGGFLSTP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 171 AGLALPALLVVLLPIIASGVIYGIpgniptarprVPVLRVVGLVwrpgtGLVLQGIGFATLSAFTALWFNERHWD--NTG 248
Cdd:cd17330 149 YGYALPFLVAAALALLNLVLVLFF----------LPPLRRLLLV-----YFLIALAFAGLESVFSLFLKDRFGFSpsQIG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 249 FAMTLFGIAFIAVR-FFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSLGVEVVRRV 327
Cdd:cd17330 214 LLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSV 293
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 27734608 328 PPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVF 367
Cdd:cd17330 294 PSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPF 333
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
16-384 |
6.09e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 6.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 16 ISAAMFLNYLTIGIPLVMLPlYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGLLml 95
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILP-AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 96 vSLIAHPVPLLawailIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGlSLYARAGLAL 175
Cdd:cd17474 81 -CGLSDSFALL-----LAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG-GLLAAISWRY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 176 PALLVVLLPIIASGVIYGIPGNIPT--ARPRVPVLRVVGLVWRPGTGLVLQGIGFATLSAFTALWF-------NERHWDN 246
Cdd:cd17474 154 PFFLLAALIPVAFLAILFLLPEPKEkaKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTylpflleLLYGISP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 247 T--GFAMTLFGIAFIAVRFFCAKF-PDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMFPSLGVEV 323
Cdd:cd17474 234 IiiGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLV 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27734608 324 VRRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVFLLAAACALLGAAVVHLL 384
Cdd:cd17474 314 TELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
93-357 |
6.58e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.46 E-value: 6.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 93 LMLVSLIAHPVPLLA------WAILIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLS 166
Cdd:cd17324 66 LLLVLLLLFILGNLLaalapsFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 167 LYARAG-LALPALLVVLLPIIASGVIYGIPGNIPTARPRVPVLRVVGLVWRPGTGLVLQGIGFATLSAFTALW------- 238
Cdd:cd17324 146 LGQLLGwRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYtylapfl 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 239 -FNERHWDNT-GFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPSAGAALIGAAITGCGCSLMF 316
Cdd:cd17324 226 tDVPGFSSSAiIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAH 305
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 27734608 317 PSLGVEVVRRVpPEIRGTALGVWSAFQDLAYGFTGPIAGLL 357
Cdd:cd17324 306 SALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLV 345
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
14-134 |
2.43e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.95 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 14 FRISA-AMFLNYLTIGIPLVMLPLYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGqFYCAASGL 92
Cdd:cd17503 180 FTLGLlLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG-LLLLALGT 258
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 27734608 93 LMLvsliAHPVPLLAWAILIVGRVLLGIGESFILTGNLTWGM 134
Cdd:cd17503 259 LLL----AFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLAL 296
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-297 |
2.59e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 18 AAMFLNYLTIGIPLVMLPLYVQQQlHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVitgqfycAASGLLMLVS 97
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAF-------AAGAAITAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 98 LIAHPV--PLLAWAILivgRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGaPLGLSLYARAGlAL 175
Cdd:cd17477 75 VLLLALtdSPWVWFLL---RFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAG-AL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 176 PALLVVLLPIIASGVIYGIPGNIP--TARPRVPVLRVVGLVWRPGTGLVLQGIGFATLSAFTALWFNERHWDN--TGFAM 251
Cdd:cd17477 150 PFLIAAVLLLLALVPLLLTRRAAPeiEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVaqAALLL 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 27734608 252 TLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPS 297
Cdd:cd17477 230 AAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPG 275
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
36-126 |
7.71e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 41.23 E-value: 7.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 36 LYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGLLMLVSliahpvplLAWAILIVGR 115
Cdd:cd17437 21 IFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVA--------PNYPVLMVGR 92
|
90
....*....|.
gi 27734608 116 VLLGIGESFIL 126
Cdd:cd17437 93 FVAGIGVGFAL 103
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
219-388 |
1.25e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 219 TGLVLQGIGFATLSAFTAL---WFNERHWDNT--GFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMW 293
Cdd:cd17355 7 VTFLILILSWGIRYYFGVFiipIIAEFGWSRAviSLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 294 AAPSAGAALIGAAIT-GCGCSLMFPSLGVEVVRRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGYQQVFLLAAA 372
Cdd:cd17355 87 LATSLWQLYLLWGLLgGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLAL 166
|
170
....*....|....*.
gi 27734608 373 CALLGAAVVHLLLRQH 388
Cdd:cd17355 167 LALLVLVPVLLLLRRR 182
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
220-363 |
1.43e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.49 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 220 GLVLQGIGFATLSAFTALWFNERHWDNT--GFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAAPS 297
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLQSFGLSASqlGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27734608 298 AGAALIGAAITGCGCSLMFPSLGVEVVRRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLLTPFIGY 363
Cdd:cd06174 84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF 149
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-161 |
1.47e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 13 LFRISAAMFLNYLTIGIPLVMLPLYvQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGQFYCAASGL 92
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27734608 93 LMLVSLIAHPVPLLAWAILIVgrvllGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGA 161
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLLL-----GFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-357 |
1.66e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 16 ISAAMFLNYLTIGIPLVMLPlYVQQQLHLSDLLIGIAVGSQFIATLLTRGAAGRKADTSGGRRTVITGqfycaaSGLLML 95
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALP-TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIG------LALFGL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 96 VSLIAHPVPLLAWaiLIVGRVLLGIGESFILTGNLTWGMWLAGSTHAGQVISWNGMATYGALAIGAPLGLSLYARAGLal 175
Cdd:cd17321 74 ASLLCALAPSLAF--LIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGW-- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 176 pallvvllpiiasGVIYGIpgNIPTArprvpvlrVVGLVWRPGT-----GLVLQGIGFATLSAFTALWFNERHWDN---T 247
Cdd:cd17321 150 -------------RWIFLI--NVPIG--------LVALLLARTFsgavlAAFLLGAALGGLLFLLPLYLQGVLGYSplqA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 248 GFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTG---LAVMWAAPSAGAALIGAAITGCGCSLMFPSLGVEVV 324
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGlllLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAAL 286
|
330 340 350
....*....|....*....|....*....|...
gi 27734608 325 RRVPPEIRGTALGVWSAFQDLAYGFTGPIAGLL 357
Cdd:cd17321 287 SSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
219-388 |
3.53e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 219 TGLVLQGIGFATLSAFTALWFNERHWDN---TGFAMTLFGIAFIAVRFFCAKFPDRYGGATVATFSLLVEGTGLAVMWAA 295
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSasiVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734608 296 PSAGAALIGAAITGCGCSLMFPSLGVEVVRRVPPEIRGTALGVWSAFQDLAYGfTGPIAGLLTPFIGYQQVFLLAAACAL 375
Cdd:cd17329 86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVA-IGPLLGGLLLLYSFRLLFLAAAVLFL 164
|
170
....*....|...
gi 27734608 376 LGAAVVHLLLRQH 388
Cdd:cd17329 165 LAALVLLFLLPET 177
|
|
| |
