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Conserved domains on  [gi|12229835|sp|Q93127|]
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RecName: Full=Probable G-protein coupled receptor No18

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606740)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
33-368 2.34e-160

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 450.34  E-value: 2.34e-160
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15060   1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLF 192
Cdd:cd15060  81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWPENFTETTPCTLTEEKGY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFFATkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd15060 161 VIYSSSGSFFIPLLIMTIVYVKIFIAT----------------------------------------------------- 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhqfieekqrislSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCaPPSQRVVDFVTWLGYVNSSL 352
Cdd:cd15060 188 ----------------------SKERRAARTLGIIMGVFVVCWLPFFLMYVILPFCETC-SPSAKVVNFITWLGYVNSAL 244
                       330
                ....*....|....*.
gi 12229835 353 NPIIYTIYNKDFRTAF 368
Cdd:cd15060 245 NPVIYTIFNLDFRRAF 260
 
Name Accession Description Interval E-value
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
33-368 2.34e-160

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 450.34  E-value: 2.34e-160
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15060   1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLF 192
Cdd:cd15060  81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWPENFTETTPCTLTEEKGY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFFATkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd15060 161 VIYSSSGSFFIPLLIMTIVYVKIFIAT----------------------------------------------------- 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhqfieekqrislSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCaPPSQRVVDFVTWLGYVNSSL 352
Cdd:cd15060 188 ----------------------SKERRAARTLGIIMGVFVVCWLPFFLMYVILPFCETC-SPSAKVVNFITWLGYVNSAL 244
                       330
                ....*....|....*.
gi 12229835 353 NPIIYTIYNKDFRTAF 368
Cdd:cd15060 245 NPVIYTIFNLDFRRAF 260
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
49-357 1.17e-63

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 203.68  E-value: 1.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835    49 GNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLL-NQWLLGSYLCQMWLTCDILCCTSSILNLCVIA 127
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835   128 LDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLG------WNDWPAQFTEDTPCTLTQERLFVVYSSSGSF 201
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFgwtltvPEGNVTVCFIDFPEDLSKPVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835   202 FIPLIIMSVVYAKIFfatkRRLRERTRKLGTLAVPAPPqrtssrplaelesvasqedetepspepeplssradkpangis 281
Cdd:pfam00001 161 LLPLLVILVCYTLII----RTLRKSASKQKSSERTQRR------------------------------------------ 194
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12229835   282 vhqfieekqrislskeRKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPS--QRVVDFVTWLGYVNSSLNPIIY 357
Cdd:pfam00001 195 ----------------RKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRllDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
42-221 5.85e-13

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 69.04  E-value: 5.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835   42 IILVTIVGNSLVIIsVFTYRPLRSVQNFFVVSLAVADLtvaLFV--LPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:PHA03087  50 IFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDL---LFVmtLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNS 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpaqfTEDTPCTLTQerlFVVYSSSG 199
Cdd:PHA03087 126 MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYT------TKKDHETLIC---CMFYNNKT 196
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 12229835  200 --------------SFFIPLIIMSVVYAKIFFATKR 221
Cdd:PHA03087 197 mnwklfinfeiniiGMLIPLTILLYCYSKILITLKG 232
 
Name Accession Description Interval E-value
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
33-368 2.34e-160

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 450.34  E-value: 2.34e-160
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15060   1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLF 192
Cdd:cd15060  81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWPENFTETTPCTLTEEKGY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFFATkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd15060 161 VIYSSSGSFFIPLLIMTIVYVKIFIAT----------------------------------------------------- 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhqfieekqrislSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCaPPSQRVVDFVTWLGYVNSSL 352
Cdd:cd15060 188 ----------------------SKERRAARTLGIIMGVFVVCWLPFFLMYVILPFCETC-SPSAKVVNFITWLGYVNSAL 244
                       330
                ....*....|....*.
gi 12229835 353 NPIIYTIYNKDFRTAF 368
Cdd:cd15060 245 NPVIYTIFNLDFRRAF 260
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
36-368 2.57e-106

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 312.96  E-value: 2.57e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd14967   3 AVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLFVVY 195
Cdd:cd14967  83 CTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIYVLV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSFFIPLIIMSVVYAKIFFAtkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradk 275
Cdd:cd14967 163 SSVISFFIPLLIMIVLYARIFRV--------------------------------------------------------- 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 276 pangisvhqfieekqrisLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQrVVDFVTWLGYVNSSLNPI 355
Cdd:cd14967 186 ------------------ARRELKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDCVPPI-LYAVFFWLGYLNSALNPI 246
                       330
                ....*....|...
gi 12229835 356 IYTIYNKDFRTAF 368
Cdd:cd14967 247 IYALFNRDFRRAF 259
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
36-368 1.88e-104

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 308.10  E-value: 1.88e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLA-IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDIL 114
Cdd:cd15064   3 ISVLLSlIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWndWPAQFTEDTPCTLTQERLFVV 194
Cdd:cd15064  83 CCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGW--RTPDSEDPSECLISQDIGYTI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 195 YSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssrad 274
Cdd:cd15064 161 FSTFGAFYIPLLLMLILYWKIYRAAAR----------------------------------------------------- 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 275 kpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqRVVDFVTWLGYVNSSLNP 354
Cdd:cd15064 188 ----------------------ERKAAKTLGIILGAFIVCWLPFFLVALIVPLCSHCWIPL-ALKSFFLWLGYFNSLINP 244
                       330
                ....*....|....
gi 12229835 355 IIYTIYNKDFRTAF 368
Cdd:cd15064 245 LIYTFFNKDFRKAF 258
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
33-368 6.41e-100

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 296.95  E-value: 6.41e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLF 192
Cdd:cd15059  81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGAEPQCELSDDPGY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd15059 161 VLFSSIGSFYIPLLIMIIVYARIYRAAKR--------------------------------------------------- 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPsQRVVDFVTWLGYVNSSL 352
Cdd:cd15059 190 -----------------------KERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTCGVP-ELLFKFFFWLGYCNSAL 245
                       330
                ....*....|....*.
gi 12229835 353 NPIIYTIYNKDFRTAF 368
Cdd:cd15059 246 NPVIYTIFNKDFRRAF 261
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
36-368 2.01e-95

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 285.32  E-value: 2.01e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15329   4 GIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDwpAQFTEDTpCTLTQERLFVVY 195
Cdd:cd15329  84 CTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKN--KVNDPGV-CQVSQDFGYQIY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSFFIPLIIMSVVYAKIFFATKrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradk 275
Cdd:cd15329 161 ATFGAFYIPLIVMLVLYYKIYRAAK------------------------------------------------------- 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 276 pangisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFC--TNCAPPSQRVVDFVTWLGYVNSSLN 353
Cdd:cd15329 186 --------------------SERKAIKTLGIIMGAFTLCWLPFFILALLRPFLkpIKCSCIPLWLSRLFLWLGYANSFLN 245
                       330
                ....*....|....*
gi 12229835 354 PIIYTIYNKDFRTAF 368
Cdd:cd15329 246 PIIYAKFNREFRTPF 260
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
38-368 1.48e-88

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 269.30  E-value: 1.48e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRS-VQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYlCQMWLTCDILCC 116
Cdd:cd15057   6 ILYLLVLLTLLGNALVIAAVLRFRHLRSkVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGSF-CDVWVSFDIMCS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL-LGW-----NDWPAQFTEDTP-CTLTQE 189
Cdd:cd15057  85 TASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVqLGWhraddTSEALALYADPCqCDSSLN 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRErtrklgtlavpappqrtssrpLAELESVASQEDETepspepepl 269
Cdd:cd15057 165 RTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRR---------------------IAALERAAQESTNP--------- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfiEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFC------TNCAPPSqrVVDFVT 343
Cdd:cd15057 215 -----------------DSSLRSSLRRETKALKTLSIIMGVFVCCWLPFFILNCVLPFCdlrtaqFPCVPDT--TFIVFV 275
                       330       340
                ....*....|....*....|....*
gi 12229835 344 WLGYVNSSLNPIIYTiYNKDFRTAF 368
Cdd:cd15057 276 WLGWANSSLNPIIYA-FNADFRKAF 299
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
42-368 3.55e-85

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 260.75  E-value: 3.55e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15065   9 IIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASIL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL-LGW--NDWPAQFTEDTP------CTLTQERLF 192
Cdd:cd15065  89 NLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIhLGWhrLSQDEIKGLNHAsnpkpsCALDLNPTY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFFATkrrlRERTRKLGTLAVPAPPQRTSSrplaelesvasqedetepspepeplssr 272
Cdd:cd15065 169 AVVSSLISFYIPCLVMLLIYSRLYLYA----RKHVVNIKSQKLPSESGSKFQ---------------------------- 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvHQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPsqRVVDFVTWLGYVNSSL 352
Cdd:cd15065 217 ----------VPSLSSKHNNQGVSDHKAAVTLGIIMGVFLICWLPFFIINIIAAFCKTCIPP--KCFKILTWLGYFNSCL 284
                       330
                ....*....|....*.
gi 12229835 353 NPIIYTIYNKDFRTAF 368
Cdd:cd15065 285 NPIIYSIFNSEFRRAF 300
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
33-368 6.55e-85

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 258.44  E-value: 6.55e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15331   1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDpINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGW--NDWPAQFTEDTPCTLTQER 190
Cdd:cd15331  81 VLCCTASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWkdEDDLDRVLKTGVCLISQDY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 LFVVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepepls 270
Cdd:cd15331 160 GYTIFSTVGAFYVPLLLMIIIYWKIYQAAKR------------------------------------------------- 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQrVVDFVTWLGYVNS 350
Cdd:cd15331 191 --------------------------ERKAARTLAIITGAFVVCWLPFFLVALVMPFCGAWQISRF-LESFFLWLGYFNS 243
                       330
                ....*....|....*...
gi 12229835 351 SLNPIIYTIYNKDFRTAF 368
Cdd:cd15331 244 LLNPIIYTIFSPDFRGAF 261
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
36-368 1.96e-83

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 254.59  E-value: 1.96e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15061   3 ISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdWPAqFTEDTPCTLTQERLFVVY 195
Cdd:cd15061  83 CTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPS-WHG-RRGLGSCYYTYDKGYRIY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradk 275
Cdd:cd15061 161 SSMGSFFLPLLLMLFVYLRIFRVIAK------------------------------------------------------ 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 276 pangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTncAPPSQRVVDFVTWLGYVNSSLNPI 355
Cdd:cd15061 187 ---------------------ERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCD--CQFSEALSTAFTWLGYFNSVINPF 243
                       330
                ....*....|...
gi 12229835 356 IYTIYNKDFRTAF 368
Cdd:cd15061 244 IYAFYNKDFRRAF 256
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
33-368 2.81e-79

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 244.18  E-value: 2.81e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLN-QWLLGSYLCQMWLTC 111
Cdd:cd15053   1 NYWALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGgKWYLGPILCDIYIAM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDtpCTLtQERL 191
Cdd:cd15053  81 DVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEE--CRF-YNPD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplss 271
Cdd:cd15053 158 FIIYSSISSFYIPCIVMLLLYYRIFRALRR-------------------------------------------------- 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFC----TNCAPPSQRVVDFVTWLGY 347
Cdd:cd15053 188 -------------------------EKKATKTLAIVLGVFLFCWLPFFTLNILNAICpklqNQSCHVGPALFSLTTWLGY 242
                       330       340
                ....*....|....*....|.
gi 12229835 348 VNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15053 243 VNSFLNPIIYTIFNIEFRKAF 263
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
37-368 5.64e-79

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 243.42  E-value: 5.64e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQ-WLLGSYLCQMWLTCDILC 115
Cdd:cd15067   4 VVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGyWLFGRDWCDVWHSFDVLA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLFVVY 195
Cdd:cd15067  84 STASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQCLFTDDSGYLIF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSFFIPLIIMSVVYAKIFfatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradk 275
Cdd:cd15067 164 SSCVSFYIPLVVMLFTYYRIY----------------------------------------------------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 276 pangisvhqfieekqrISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFC-TNCAPPSQRVVDFVTWLGYVNSSLNP 354
Cdd:cd15067 185 ----------------RAAAKEQKAAKTLGIVMGVFILCWLPFFVTNILIGFCpSNCVSNPDILFPLVTWLGYINSGMNP 248
                       330
                ....*....|....
gi 12229835 355 IIYTIYNKDFRTAF 368
Cdd:cd15067 249 IIYACSSRDFRRAF 262
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
33-368 1.76e-78

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 243.01  E-value: 1.76e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15051   1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL-LGWN--DWPAQFTED-TPCTLTQ 188
Cdd:cd15051  81 VMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIhLGWNtpDGRVQNGDTpNQCRFEL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ERLFVVYSSSGSFFIPLIIMSVVYAKIFfatkRRLRERTRKLgtlavpappqrtssrplaelesvasqedetepspepep 268
Cdd:cd15051 161 NPPYVLLVAIGTFYLPLLIMCGVYLRIF----RIAREQAKRI-------------------------------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lssradkpaNGISVHQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNcaPPSQRVVDFVTWLGYV 348
Cdd:cd15051 199 ---------NALTPASTANSSKSAATAREHKATVTLAAVLGAFIICWFPYFTYFTYRGLCGD--NINETALSVVLWLGYA 267
                       330       340
                ....*....|....*....|
gi 12229835 349 NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15051 268 NSALNPILYAFLNRDFRRAF 287
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
33-368 1.12e-77

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 240.27  E-value: 1.12e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15330   1 IITSLFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDwPAQFTEDTPCTLTQERLF 192
Cdd:cd15330  81 VLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRT-PEDRSDPDACTISKDPGY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd15330 160 TIYSTFGAFYIPLILMLVLYGRIFKAAAR--------------------------------------------------- 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFC-TNCAPPsQRVVDFVTWLGYVNSS 351
Cdd:cd15330 189 ------------------------ERKTVKTLGIIMGTFILCWLPFFIVALVLPFCeSTCHMP-ELLGAIINWLGYSNSL 243
                       330
                ....*....|....*..
gi 12229835 352 LNPIIYTIYNKDFRTAF 368
Cdd:cd15330 244 LNPIIYAYFNKDFQSAF 260
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
36-368 1.17e-75

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 234.96  E-value: 1.17e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15066   3 GFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS-VPPLLGWNDWPA--QFTEDTP--CTLTQER 190
Cdd:cd15066  83 STASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISfLPIFLGWYTTEEhlQYRKTHPdqCEFVVNK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 LFVVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepepls 270
Cdd:cd15066 163 IYALISSSVSFWIPCIVMIFTYYRIYLEAKR------------------------------------------------- 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGYVNS 350
Cdd:cd15066 194 --------------------------EHKAAKTLGIIMGAFILCWLPFFLWYVTTTLCGDACPYPPILVSILFWIGYFNS 247
                       330
                ....*....|....*...
gi 12229835 351 SLNPIIYTIYNKDFRTAF 368
Cdd:cd15066 248 TLNPLIYAYFNRDFREAF 265
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
37-368 4.06e-75

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 233.54  E-value: 4.06e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15063   5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTP-------CTLTQE 189
Cdd:cd15063  85 TASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGssslpctCELTNG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepepl 269
Cdd:cd15063 165 RGYVIYSALGSFYIPMLVMLFFYFRIYRAARM------------------------------------------------ 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFvtWLGYVN 349
Cdd:cd15063 197 ---------------------------ETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPPLLFSVFF--WLGYCN 247
                       330
                ....*....|....*....
gi 12229835 350 SSLNPIIYTIYNKDFRTAF 368
Cdd:cd15063 248 SALNPCIYALFSRDFRFAF 266
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
29-368 8.08e-73

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 227.76  E-value: 8.08e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  29 LGETVAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMW 108
Cdd:cd15333   1 LGLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIW 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 109 LTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgWNDWPAQfTEDTPCTL-T 187
Cdd:cd15333  81 LSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFF-WRQAKAE-EEVSECVVnT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 QERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRlrertrklgtlavpappqrtssrplaelesvasqedetepspepe 267
Cdd:cd15333 159 DHILYTVYSTVGAFYIPTLLLIALYGRIYVEARAR--------------------------------------------- 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 268 plssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGY 347
Cdd:cd15333 194 -----------------------------ERKATKTLGIILGAFIVCWLPFFIISLVLPICKDACWFHLAIFDFFTWLGY 244
                       330       340
                ....*....|....*....|.
gi 12229835 348 VNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15333 245 LNSLINPIIYTMSNEDFKQAF 265
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
32-368 1.95e-72

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 227.11  E-value: 1.95e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  32 TVAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTC 111
Cdd:cd15321   6 TAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLAL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERL 191
Cdd:cd15321  86 DVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLNEEAW 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGSFFIPLIIMSVVYAKIFFATKRRlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplss 271
Cdd:cd15321 166 YILSSSIGSFFAPCLIMILVYLRIYLIAKNR------------------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGYVNSS 351
Cdd:cd15321 197 -------------------------EKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPELCKVPHSLFQFFFWIGYCNSS 251
                       330
                ....*....|....*..
gi 12229835 352 LNPIIYTIYNKDFRTAF 368
Cdd:cd15321 252 LNPVIYTIFNQDFRRAF 268
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
33-368 5.16e-72

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 226.95  E-value: 5.16e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15058   1 PGLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS-VPPLLGW---NDWPAQ--FTEDTPCTL 186
Cdd:cd15058  81 VLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSfVPIMNQWwraNDPEANdcYQDPTCCDF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLAVPAPPQRTSSRPlaelesvasqedetepspep 266
Cdd:cd15058 161 RTNMAYAIASSVVSFYIPLLIMIFVYARVFLIATRQLQLIDKRRLRFQSECPAPQTTSPE-------------------- 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssraDKPANGISvhqfieeKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPpsQRVVDFVTWLG 346
Cdd:cd15058 221 -------GKRSSGRR-------PSRLTVVKEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPP--GEVFLLLNWLG 284
                       330       340
                ....*....|....*....|..
gi 12229835 347 YVNSSLNPIIYTiYNKDFRTAF 368
Cdd:cd15058 285 YINSGLNPIIYC-RSPEFRTAF 305
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
33-368 4.22e-71

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 223.26  E-value: 4.22e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15335   1 MLIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgwndWPAQFTEDTP--CTLTQER 190
Cdd:cd15335  81 MTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLF----WRNHHDANIPsqCIIQHDH 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 L-FVVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepepl 269
Cdd:cd15335 157 ViYTIYSTFGAFYIPLTLILILYYRIYHAASR------------------------------------------------ 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFctNCAPPSQRVVDFVTWLGYVN 349
Cdd:cd15335 189 ---------------------------ERKAARILGLILGAFILSWLPFFIKELIVGL--SVMTVSPEVADFLTWLGYVN 239
                       330
                ....*....|....*....
gi 12229835 350 SSLNPIIYTIYNKDFRTAF 368
Cdd:cd15335 240 SLVNPLLYTSFNEDFKLAF 258
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
37-368 4.07e-70

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 220.58  E-value: 4.07e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15323   5 AVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQftEDTP-CTLTQERLFVVY 195
Cdd:cd15323  85 TSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEG--DVYPqCKLNDETWYILS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSFFIPLIIMSVVYAKIFfatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradk 275
Cdd:cd15323 163 SCIGSFFAPCLIMILVYIRIY----------------------------------------------------------- 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 276 pangisvhqfieekqRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGYVNSSLNPI 355
Cdd:cd15323 184 ---------------RVAKAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICREACEVPEPLFKFFFWIGYCNSSLNPV 248
                       330
                ....*....|...
gi 12229835 356 IYTIYNKDFRTAF 368
Cdd:cd15323 249 IYTIFNQDFRRSF 261
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
36-361 2.73e-69

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 219.08  E-value: 2.73e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd00637   2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDW---PAQFTEDTPCTLTQERLF 192
Cdd:cd00637  82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYdygGYCCCCLCWPDLTLSKAY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFfatkRRLRERTRKLGTlavpappqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd00637 162 TIFLFVLLFLLPLLVIIVCYVRIF----RKLRRHRRRIRS---------------------------------------- 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGYVNSSL 352
Cdd:cd00637 198 -----------SSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAI 266

                ....*....
gi 12229835 353 NPIIYTIYN 361
Cdd:cd00637 267 NPIIYAFFN 275
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
42-368 1.28e-67

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 214.42  E-value: 1.28e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15322  10 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTpCTLTQERLFVVYSSSGSF 201
Cdd:cd15322  90 HLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPI-CKINDEKWYIISSCIGSF 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 202 FIPLIIMSVVYAKIFfatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradkpangis 281
Cdd:cd15322 169 FAPCLIMVLVYIRIY----------------------------------------------------------------- 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 282 vhqfieekqRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPpsQRVVDFVTWLGYVNSSLNPIIYTIYN 361
Cdd:cd15322 184 ---------QIAKNREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCDCSVP--ETLFKFFFWFGYCNSSLNPVIYTIFN 252

                ....*..
gi 12229835 362 KDFRTAF 368
Cdd:cd15322 253 HDFRRAF 259
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
38-368 4.20e-67

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 212.94  E-value: 4.20e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLL-NQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15052   6 LLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFgGVWPLPLVLCLLWVTLDVLFC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP-PLLGWNDwPAQFTEDTPCTLTqERLFVVY 195
Cdd:cd15052  86 TASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPiPVLGIID-TTNVLNNGTCVLF-NPNFVIY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSFFIPLIIMSVVYAKIFFAtkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradk 275
Cdd:cd15052 164 GSIVAFFIPLLIMVVTYALTIRL--------------------------------------------------------- 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 276 pangisvhqfieekqrisLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPP-SQRVVDFVTWLGYVNSSLNP 354
Cdd:cd15052 187 ------------------LSNEQKASKVLGIVFAVFVICWCPFFITNILTGLCEECNCRiSPWLLSVFVWLGYVSSTINP 248
                       330
                ....*....|....
gi 12229835 355 IIYTIYNKDFRTAF 368
Cdd:cd15052 249 IIYTIFNKTFRRAF 262
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
38-368 6.02e-67

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 214.48  E-value: 6.02e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRS-VQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYlCQMWLTCDILCC 116
Cdd:cd15320   7 FLSVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS-VPPLLGWNDW-PAQFTE------DTP---CT 185
Cdd:cd15320  86 TASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfIPVQLNWHKAkPTSFLDlnaslrDLTmdnCD 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 186 LTQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLReRTRKLGTLAVPAPPQRTSSRPLAELESvasqedetepspe 265
Cdd:cd15320 166 SSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIR-RISALERAAVHAKNCQNSTGNRGSGDC------------- 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 266 peplssradkpangisvhQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFC--TNCAPP--SQRVVDF 341
Cdd:cd15320 232 ------------------QQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCkpTSTEPFciSSTTFDV 293
                       330       340
                ....*....|....*....|....*..
gi 12229835 342 VTWLGYVNSSLNPIIYTiYNKDFRTAF 368
Cdd:cd15320 294 FVWFGWANSSLNPIIYA-FNADFRKAF 319
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
38-368 3.56e-66

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 211.26  E-value: 3.56e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15055   6 VLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTP---CTLTQERLFVV 194
Cdd:cd15055  86 ASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRYNSCygeCVVVVNFIWGV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 195 YSSSGSFFIPLIIMSVVYAKIFFATKRRLRertrklgtlavpappqrtssrplaELESVASQEDETepspepeplssrad 274
Cdd:cd15055 166 VDLVLTFILPCTVMIVLYMRIFVVARSQAR------------------------AIRSHTAQVSLE-------------- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 275 kpangisvhqfiEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNcaPPSqrVVDFVTWLGYVNSSLNP 354
Cdd:cd15055 208 ------------GSSKKVSKKSERKAAKTLGIVVGVFLLCWLPYYIVSLVDPYIST--PSS--VFDVLIWLGYFNSCLNP 271
                       330
                ....*....|....
gi 12229835 355 IIYTIYNKDFRTAF 368
Cdd:cd15055 272 LIYALFYPWFRKAL 285
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
38-368 4.13e-66

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 210.95  E-value: 4.13e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15314   6 FLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP-PLLGWNDWPAQFTEDT---PCTLTQERLFV 193
Cdd:cd15314  86 ASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGiIFLELNIKGIYYNHVAcegGCLVFFSKVSS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 VYSSSGSFFIPLIIMSVVYAKIFFATKRRLRertrklgtlavpappqrtssrplaelesvasqedetepspepeplssra 273
Cdd:cd15314 166 VVGSVFSFYIPAVIMLCIYLKIFLVAQRQAR------------------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 274 dkpangiSVHQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqrVVDFVTWLGYVNSSLN 353
Cdd:cd15314 197 -------SIQSARTKSGASSSKMERKATKTLAIVMGVFLLCWTPFFLCNIIDPFINYSIPPV--LIEVLNWLGYSNSTLN 267
                       330
                ....*....|....*
gi 12229835 354 PIIYTIYNKDFRTAF 368
Cdd:cd15314 268 PFIYAFFYSWFRKAF 282
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
33-368 2.61e-65

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 208.26  E-value: 2.61e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIvgNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15334   3 ISLTLSILALMTTAI--NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgwndWPAQFTE-DTPCTLTQERL 191
Cdd:cd15334  81 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLF----WRHQTTSrEDECIIKHDHI 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 -FVVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepepls 270
Cdd:cd15334 157 vFTIYSTFGAFYIPLALILILYYKIYRAATR------------------------------------------------- 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCApPSQRVVDFVTWLGYVNS 350
Cdd:cd15334 188 --------------------------ERKAATTLGLILGAFVICWLPFFVKEVIVNTCDSCY-ISEEMSNFLTWLGYINS 240
                       330
                ....*....|....*...
gi 12229835 351 SLNPIIYTIYNKDFRTAF 368
Cdd:cd15334 241 LINPLIYTIFNEDFKKAF 258
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
42-368 1.04e-64

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 206.90  E-value: 1.04e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15050  10 ISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVpPLLGWNDWPAQFTEDTP-----CTLTQERLFVVYS 196
Cdd:cd15050  90 SLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVI-PILGWHHFARGGERVVLedkceTDFHDVTWFKVLT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 197 SSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradkp 276
Cdd:cd15050 169 AILNFYIPSLLMLWFYAKIFKAVNR------------------------------------------------------- 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 277 angisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVvdFVTWLGYVNSSLNPII 356
Cdd:cd15050 194 --------------------ERKAAKQLGFIMAAFILCWIPYFILFMVIAFCKNCCNENLHM--FTIWLGYINSTLNPFI 251
                       330
                ....*....|..
gi 12229835 357 YTIYNKDFRTAF 368
Cdd:cd15050 252 YPLCNENFKKTF 263
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
38-368 2.21e-64

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 205.90  E-value: 2.21e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15326   6 VLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQftEDTPCTLTQERLFVVYSS 197
Cdd:cd15326  86 ASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPP--DDKVCEITEEPFYALFSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 198 SGSFFIPLIIMSVVYAKIFFATkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradkpa 277
Cdd:cd15326 164 LGSFYIPLIVILVMYCRVYIVA---------------------------------------------------------- 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 278 ngisvhqfieekqrISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPsQRVVDFVTWLGYVNSSLNPIIY 357
Cdd:cd15326 186 --------------LKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHLKPP-ETLFKIIFWLGYFNSCLNPIIY 250
                       330
                ....*....|.
gi 12229835 358 TIYNKDFRTAF 368
Cdd:cd15326 251 PCSSKEFKRAF 261
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
42-368 2.68e-64

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 205.49  E-value: 2.68e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15324  10 IILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgwndwpAQFTEDTPCTLTQERLFVVYSSSGSF 201
Cdd:cd15324  90 HLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLL------MTKHDEWECLLNDETWYILSSCTVSF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 202 FIPLIIMSVVYAKIFfatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradkpangis 281
Cdd:cd15324 164 FAPGLIMILVYCKIY----------------------------------------------------------------- 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 282 vhqfieekqRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGYVNSSLNPIIYTIYN 361
Cdd:cd15324 179 ---------RVAKMREKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCRKRCGIPDALFNLFFWIGYCNSSVNPIIYTIFN 249

                ....*..
gi 12229835 362 KDFRTAF 368
Cdd:cd15324 250 RDFRKAF 256
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
49-357 1.17e-63

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 203.68  E-value: 1.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835    49 GNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLL-NQWLLGSYLCQMWLTCDILCCTSSILNLCVIA 127
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835   128 LDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLG------WNDWPAQFTEDTPCTLTQERLFVVYSSSGSF 201
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFgwtltvPEGNVTVCFIDFPEDLSKPVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835   202 FIPLIIMSVVYAKIFfatkRRLRERTRKLGTLAVPAPPqrtssrplaelesvasqedetepspepeplssradkpangis 281
Cdd:pfam00001 161 LLPLLVILVCYTLII----RTLRKSASKQKSSERTQRR------------------------------------------ 194
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12229835   282 vhqfieekqrislskeRKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPS--QRVVDFVTWLGYVNSSLNPIIY 357
Cdd:pfam00001 195 ----------------RKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRllDKALSVTLWLAYVNSCLNPIIY 256
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
33-368 6.47e-62

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 201.34  E-value: 6.47e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRS-VQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYlCQMWLTC 111
Cdd:cd15319   1 VVTGCLLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAF-CDVWVAF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS-VPPLLGWN-----DWPAQFTEDTP-- 183
Cdd:cd15319  80 DIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISfIPVQLNWHkdsgdDWVGLHNSSISrq 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 184 ----CTLTQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLReRTRKLGTLAVPAPPQRTSSRPLAELESVasqede 259
Cdd:cd15319 160 veenCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIR-RISSLERAAEHAQSCRSNRIDCHHHTSL------ 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 260 tepspepeplssradkpangisvhqfieekqRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCA--PP--- 334
Cdd:cd15319 233 -------------------------------RTSIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRPPadPDagl 281
                       330       340       350
                ....*....|....*....|....*....|....*..
gi 12229835 335 ---SQRVVDFVTWLGYVNSSLNPIIYTiYNKDFRTAF 368
Cdd:cd15319 282 pcvSETTFDVFVWFGWANSSLNPIIYA-FNADFRKVF 317
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
39-368 1.44e-59

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 193.47  E-value: 1.44e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  39 LLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTS 118
Cdd:cd15062   7 LGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 119 SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDwPAQfTEDTPCTLTQERLFVVYSSS 198
Cdd:cd15062  87 SIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKE-PAP-ADEQACGVNEEPGYVLFSSL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 199 GSFFIPLIIMSVVYAKIFFATkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradkpan 278
Cdd:cd15062 165 GSFYLPLAIILVMYCRVYVVA----------------------------------------------------------- 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 279 gisvhqfieekqrISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQrVVDFVTWLGYVNSSLNPIIYT 358
Cdd:cd15062 186 -------------FKFSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTLKPPEP-VFKVVFWLGYFNSCLNPIIYP 251
                       330
                ....*....|
gi 12229835 359 IYNKDFRTAF 368
Cdd:cd15062 252 CSSREFKRAF 261
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
34-368 1.85e-59

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 194.74  E-value: 1.85e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15959   2 LAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLG--WN---DWPAQFTEDTP--CTL 186
Cdd:cd15959  82 LCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNqwWRdgaDEEAQRCYDNPrcCDF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLaVPAPPQRTSSRPlaelesvasqedetepspep 266
Cdd:cd15959 162 VTNMPYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVRLIRKDKVRF-PPEESPPAESRP-------------------- 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplsSRADKPANGISVhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPpsQRVVDFVTWLG 346
Cdd:cd15959 221 ----ACGRRPSRLLAI-------------KEHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRSLVP--DPAFLFLNWLG 281
                       330       340
                ....*....|....*....|..
gi 12229835 347 YVNSSLNPIIYTiYNKDFRTAF 368
Cdd:cd15959 282 YANSAFNPIIYC-RSPDFRSAF 302
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
33-368 1.99e-59

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 194.24  E-value: 1.99e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15056   1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPInYAQKRTIRRVNTMIAAVWALSLVISVPPLL-GWND-------WPAQFTEDTPC 184
Cdd:cd15056  81 VLLTTASIMHLCCIALDRYYAICCQP-LVYKMTPLRVAVMLGGCWVIPTFISFLPIMqGWNHigiedliAFNCASGSTSC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 185 TLTQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLR--ERTRKLGTLAVPAPPQRTSsrplaelesvasqedetep 262
Cdd:cd15056 160 VFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHqiRSLQRAGSSNHEADQHRNS------------------- 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvhqfieekqriSLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPpsQRVVDFV 342
Cdd:cd15056 221 ------------------------------RMRTETKAAKTLGIIMGCFCVCWAPFFVTNIVDPFIGYRVP--YLLWTAF 268
                       330       340
                ....*....|....*....|....*.
gi 12229835 343 TWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15056 269 LWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
33-368 4.05e-59

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 193.34  E-value: 4.05e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15312   1 VAMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALS------LVISVPPLLGWNDWPAQFTEDTPCTL 186
Cdd:cd15312  81 MMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPclfafgVVFSEVNLEGIEDYVALVSCTGSCVL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRErtrklgtlavpappqrtssrplaelesvasqedetepspep 266
Cdd:cd15312 161 IFNKLWGVIASLIAFFIPGTVMIGIYIKIFFVARKHAKV----------------------------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpANGISVHQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqrVVDFVTWLG 346
Cdd:cd15312 200 ----------INNRPSVTKGDSKNKLSKKKERKAAKTLSIVMGVFLLCWLPFFVATLIDPFLNFSTPVD--LFDALVWLG 267
                       330       340
                ....*....|....*....|..
gi 12229835 347 YVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15312 268 YFNSTCNPLIYGFFYPWFQKAF 289
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
38-368 9.08e-59

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 191.64  E-value: 9.08e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15325   6 ILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDwPAQfTEDTPCTLTQERLFVVYSS 197
Cdd:cd15325  86 ASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKE-PAP-EDETICQITEEPGYALFSA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 198 SGSFFIPLIIMSVVYAKIFFATkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradkpa 277
Cdd:cd15325 164 LGSFYLPLAIILVMYCRVYVVA---------------------------------------------------------- 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 278 ngisvhqfieekqrISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNcAPPSQRVVDFVTWLGYVNSSLNPIIY 357
Cdd:cd15325 186 --------------LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPA-YKPSDTVFKITFWLGYFNSCINPIIY 250
                       330
                ....*....|.
gi 12229835 358 TIYNKDFRTAF 368
Cdd:cd15325 251 PCSSQEFKKAF 261
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
34-368 1.02e-57

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 190.11  E-value: 1.02e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIV-GNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15958   1 AGMSLLMALIVLLIVaGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS-VPPLLGWndWPAQFTEDTP-------C 184
Cdd:cd15958  81 VLCVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSfLPIMMHW--WRDEDDQALKcyedpgcC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 185 TLTQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGT-LAVPAPPQRTSSRPLAelesvasqedeteps 263
Cdd:cd15958 159 DFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQIKKIDKCEGRfHNTLTGLGRKCKRRPS--------------- 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfieekqRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPpsQRVVDFVT 343
Cdd:cd15958 224 ---------------------------RILALREQKALKTLGIIMGVFTLCWLPFFLVNVVNVFNRELVP--DWLFVFFN 274
                       330       340
                ....*....|....*....|....*
gi 12229835 344 WLGYVNSSLNPIIYTiYNKDFRTAF 368
Cdd:cd15958 275 WLGYANSAFNPIIYC-RSPDFRKAF 298
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
33-368 1.04e-57

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 188.62  E-value: 1.04e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQ-WLLGSYLCQMWLTC 111
Cdd:cd15328   1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRrWQLGRSLCQVWISF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL-GWNDWPAQFTEDtpCTLTQER 190
Cdd:cd15328  81 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLfGWGETYSEDSEE--CQVSQEP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 LFVVYSSSGSFFIPLIIMSVVYAKIFFATKrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepepls 270
Cdd:cd15328 159 SYTVFSTFGAFYLPLCVVLFVYWKIYKAAQ-------------------------------------------------- 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpangisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVdfVTWLGYVNS 350
Cdd:cd15328 189 -------------------------KEKRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPPIWKSI--FLWLGYSNS 241
                       330
                ....*....|....*...
gi 12229835 351 SLNPIIYTIYNKDFRTAF 368
Cdd:cd15328 242 FFNPLIYTAFNKNYNNAF 259
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
33-368 6.46e-57

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 187.90  E-value: 6.46e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15048   1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWP-----------AQFTED 181
Cdd:cd15048  81 YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTgysivptgdceVEFFDH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 182 TPCTLTqerlfvvySSSGSFFIPLIIMSVVYAKIFfatkRRLRERTRKlgtLAVPAPPQRTSSRplaELESVASQedete 261
Cdd:cd15048 161 FYFTFI--------TSVLEFFIPFISVSFFNLLIY----LNIRKRSRR---RPLRSVPILPASQ---NPSRARSQ----- 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 262 pspepeplssradkpangisvhqfieeKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFC-TNCapPSQRVVD 340
Cdd:cd15048 218 ---------------------------REQVKLRRDRKAAKSLAILVLVFLICWAPYTILTIIRSFCsGSC--VDSYLYE 268
                       330       340
                ....*....|....*....|....*...
gi 12229835 341 FVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15048 269 FTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
33-368 2.71e-56

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 185.12  E-value: 2.71e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15327   1 VGVGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAqfTEDTPCTLTQERLF 192
Cdd:cd15327  81 VLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPP--PDESICSITEEPGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFFATkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd15327 159 ALFSSLFSFYLPLMVILVMYFRVYVVA----------------------------------------------------- 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhqfieekqrISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCApPSQRVVDFVTWLGYVNSSL 352
Cdd:cd15327 186 -------------------LKFSREKKAAKTLAIVVGVFILCWFPFFFVLPLGSFFPALK-PSEMVFKVIFWLGYFNSCV 245
                       330
                ....*....|....*.
gi 12229835 353 NPIIYTIYNKDFRTAF 368
Cdd:cd15327 246 NPIIYPCSSKEFKRAF 261
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
33-368 5.56e-56

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 184.45  E-value: 5.56e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15049   1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGW-----------NDWPAQFTED 181
Cdd:cd15049  81 YVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWqyfvgertvpdGQCYIQFLDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 182 TPctltqerlFVVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedete 261
Cdd:cd15049 161 PA--------ITFGTAIAAFYLPVLVMTILYWRIYRETAR---------------------------------------- 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 262 pspepeplssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPpsQRVVDF 341
Cdd:cd15049 193 -----------------------------------ERKAARTLSAILLAFIITWTPYNILVLVSTFCAKCIP--DTLWSF 235
                       330       340
                ....*....|....*....|....*..
gi 12229835 342 VTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15049 236 GYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
41-368 8.67e-55

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 181.32  E-value: 8.67e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15310   9 ALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGgVWNFSRICCDVFVTLDVMMCTAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRT---IRRVNTMIAAVWALSLVISVPPLLGWNdwpaqfTEDTP--CTLTQErLFVV 194
Cdd:cd15310  89 ILNLCAISIDRYTAVVMPVHYQHGTGqssCRRVSLMITAVWVLAFAVSCPLLFGFN------TTGDPtvCSISNP-DFVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 195 YSSSGSFFIPLIIMSVVYAKIFfatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssrad 274
Cdd:cd15310 162 YSSVVSFYLPFGVTLLVYVRIY---------------------------------------------------------- 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 275 kpangisvhqfieekqrISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQrVVDFVTWLGYVNSSLNP 354
Cdd:cd15310 184 -----------------VVLLREKKATQMLAIVLGAFIVCWLPFFLTHILNTHCQACHVPPE-LYSATTWLGYVNSALNP 245
                       330
                ....*....|....
gi 12229835 355 IIYTIYNKDFRTAF 368
Cdd:cd15310 246 VIYTTFNIEFRRAF 259
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
33-368 1.02e-54

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 180.80  E-value: 1.02e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQ-WLLGSYLCQMWLTC 111
Cdd:cd15308   1 AAALVGGVLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGvWTLSPVLCDALMTM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQftEDTPCTLtQERL 191
Cdd:cd15308  81 DVMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNR--DPAVCKL-EDNN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGSFFIPLIIMSVVYAKIFfatkrrlrertRKLGtlavpappqrtssrplaelesvasqedetepspepeplss 271
Cdd:cd15308 158 YVVYSSVCSFFIPCPVMLVLYCAMF-----------RGLG---------------------------------------- 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpangisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQrVVDFVTWLGYVNSS 351
Cdd:cd15308 187 ------------------------RERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCSIPPQ-LISIVTWLGYVNSA 241
                       330
                ....*....|....*..
gi 12229835 352 LNPIIYTIYNKDFRTAF 368
Cdd:cd15308 242 LNPVIYTVFNAEFRNVF 258
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
33-368 3.32e-54

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 180.83  E-value: 3.32e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15957   1 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL-LGWNDWPAQ-----FTEDTPCTL 186
Cdd:cd15957  81 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIqMHWYRATHQeaincYAEETCCDF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLAVPAPPQRTSsrplaelesvasqedetepspep 266
Cdd:cd15957 161 FTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHNQNIDQNGS----------------------- 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssrADKPANGISVHQFIeekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPpsQRVVDFVTWLG 346
Cdd:cd15957 218 ------GGGGGNRRRSKFCL---------KEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIR--KEVYILLNWIG 280
                       330       340
                ....*....|....*....|..
gi 12229835 347 YVNSSLNPIIYTiYNKDFRTAF 368
Cdd:cd15957 281 YVNSGFNPLIYC-RSPDFRIAF 301
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
33-368 4.54e-53

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 176.92  E-value: 4.54e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15054   1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL-LGWND---WPAQFTEDTPCTLTQ 188
Cdd:cd15054  81 VMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIeLGWHElghERTLPNLTSGTVEGQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ERL-----FVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLrertrklgtlavpappqrtssrplaelesvasqedeteps 263
Cdd:cd15054 161 CRLlvslpYALVASCLTFFLPSGAICFTYCRILLAARKAL---------------------------------------- 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfieekqrislskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFCtNCAPPSqrVVDFVT 343
Cdd:cd15054 201 -----------------------------------KASLTLGILLGMFFVTWLPFFVANVVQAVC-DCVSPG--LFDVLT 242
                       330       340
                ....*....|....*....|....*
gi 12229835 344 WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15054 243 WLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
35-375 3.26e-52

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 175.02  E-value: 3.26e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQ-WLLGSYLCQMWLTCDI 113
Cdd:cd15306   3 AALLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAmWPLPLVLCPIWLFLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP-PLLGWNDWPAqFTEDTPCTLTQERL- 191
Cdd:cd15306  83 LFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPvPIKGIETDVD-NPNNITCVLTKERFg 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 -FVVYSSSGSFFIPLIIMSVVYakifFATKRRLRERTrklgtlavpappqrtssrplaelesvasqedetepspepepls 270
Cdd:cd15306 162 dFILFGSLAAFFTPLAIMIVTY----FLTIHALRKQT------------------------------------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpangisvhqfieekqrisLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNC-APPSQRVVDFVTWLGYVN 349
Cdd:cd15306 195 -----------------------ITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDSCnQTTLQMLMEIFVWIGYVS 251
                       330       340
                ....*....|....*....|....*.
gi 12229835 350 SSLNPIIYTIYNKDFRTAFSRLLRCD 375
Cdd:cd15306 252 SGVNPLVYTLFNKTFRDAFGRYITCN 277
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
38-374 1.25e-50

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 170.86  E-value: 1.25e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILCC 116
Cdd:cd15305   6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP-PLLGWNDWPAQFTEDTpCTLTQErLFVVY 195
Cdd:cd15305  86 TASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPiPVIGLQDDEKVFVNGT-CVLNDE-NFVLI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSFFIPLIIMSVVYAKIFFATKRRLrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradk 275
Cdd:cd15305 164 GSFVAFFIPLIIMVITYCLTIQVLQRQQ---------------------------------------------------- 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 276 pangisvhqfieekqriSLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPS--QRVVDFVTWLGYVNSSLN 353
Cdd:cd15305 192 -----------------AINNERRASKVLGIVFFLFLIMWCPFFITNILSVLCKEACDQKlmEELLNVFVWVGYVSSGIN 254
                       330       340
                ....*....|....*....|.
gi 12229835 354 PIIYTIYNKDFRTAFSRLLRC 374
Cdd:cd15305 255 PLVYTLFNKTYRRAFSNYIRC 275
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
39-368 2.79e-50

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 170.32  E-value: 2.79e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  39 LLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTS 118
Cdd:cd15317   7 LVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 119 SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL-LGWND-WPAQFTEDTPCTLTQERLF---V 193
Cdd:cd15317  87 SIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIyTGANDeGLEEYSSEISCVGGCQLLFnkiW 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 VYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLavpappqrtssRPLAELESVASQedetepspepeplssra 273
Cdd:cd15317 167 VLLDFLTFFIPCLIMIGLYAKIFLVARRQARKIQNMEDKF-----------RSSEENSSKASA----------------- 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 274 dkpangisvhqfieekqrislSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqrVVDFVTWLGYVNSSLN 353
Cdd:cd15317 219 ---------------------SRERKAAKTLAIVMGIFLFCWLPYFIDTIVDEYSNFITPAI--VFDAVIWLGYFNSAFN 275
                       330
                ....*....|....*
gi 12229835 354 PIIYTIYNKDFRTAF 368
Cdd:cd15317 276 PFIYAFFYPWFRKAF 290
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
38-374 4.65e-49

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 167.05  E-value: 4.65e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15307   6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTqERLFVVYSS 197
Cdd:cd15307  86 ASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVLVNGTCQIP-DPVYKLVGS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 198 SGSFFIPLIIMSVVYAkiffATKRRLRERTRKLGTLavpappqrtssrplaelesvasqedetepspepeplssradkpa 277
Cdd:cd15307 165 IVCFYIPLGVMLLTYC----LTVRLLARQRSRHGRI-------------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 278 ngisvhqfieekqrisLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNC-APPSQRVVDFVTWLGYVNSSLNPII 356
Cdd:cd15307 197 ----------------IRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECeERISHWVFDVVTWLGYASSMVNPIF 260
                       330
                ....*....|....*...
gi 12229835 357 YTIYNKDFRTAFSRLLRC 374
Cdd:cd15307 261 YTIFNKVFRQAFKKVLLC 278
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
33-368 2.69e-48

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 165.47  E-value: 2.69e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQM--WLT 110
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAvpYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 111 CdiLCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTP-----CT 185
Cdd:cd14993  81 G--VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGTitiyiCT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 186 ----LTQER------LFVVysssgSFFIPLIIMSVVYAKIFfatkRRLRERTrklgtlavpAPPQRTSSRplaelesvas 255
Cdd:cd14993 159 edwpSPELRkaynvaLFVV-----LYVLPLLIISVAYSLIG----RRLWRRK---------PPGDRGSAN---------- 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 256 qedetepspepeplssradkpangisvhqfIEEKQRISLSKeRKAARVLGVIMGVFVVCWLPFFLMYAIV----PFCTNC 331
Cdd:cd14993 211 ------------------------------STSSRRILRSK-KKVARMLIVVVVLFALSWLPYYVLSILLdfgpLSSEES 259
                       330       340       350
                ....*....|....*....|....*....|....*..
gi 12229835 332 APPSQRVVDFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14993 260 DENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
38-368 1.62e-46

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 159.71  E-value: 1.62e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILCC 116
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP-PLLGWNDWPAQFTEDTpCTLTQERlFVVY 195
Cdd:cd15304  86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPiPVFGLQDDSKVFKEGS-CLLADEN-FVLI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSFFIPLIIMSVVYakifFATKRRLRErtrklgtlavpappqrtssrplaelesvasqedetepspepeplssradk 275
Cdd:cd15304 164 GSFVAFFIPLTIMVITY----FLTIKSLQQ-------------------------------------------------- 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 276 pangisvhqfieekqriSLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPS--QRVVDFVTWLGYVNSSLN 353
Cdd:cd15304 190 -----------------SISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICKESCNEVviGGLLNVFVWIGYLSSAVN 252
                       330
                ....*....|....*
gi 12229835 354 PIIYTIYNKDFRTAF 368
Cdd:cd15304 253 PLVYTLFNKTYRSAF 267
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
36-368 8.81e-46

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 158.57  E-value: 8.81e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAyrLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd14968   4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAIL--ISLGLPTNFHGCLFMACLVLVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAqfTEDTPCTLTQERLF--- 192
Cdd:cd14968  82 TQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAP--LESGCGEGGIQCLFeev 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 ------VVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTlavpappqrtssrplaelesvasqedetepspep 266
Cdd:cd14968 160 ipmdymVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRS---------------------------------- 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangisvhqfieEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqRVVDFVTWLG 346
Cdd:cd14968 206 ---------------------RRSRSTLQKEVKAAKSLAIILFLFALCWLPLHIINCITLFCPECKVPK-ILTYIAILLS 263
                       330       340
                ....*....|....*....|..
gi 12229835 347 YVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14968 264 HANSAVNPIVYAYRIRKFRQTF 285
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
33-374 1.21e-45

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 157.80  E-value: 1.21e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAII-LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTC 111
Cdd:cd15299   3 VVLIAFLTGILaLVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFT---EDTPCTLTQ 188
Cdd:cd15299  83 DYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTvppDECFIQFLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ERLFVVYSSSGSFFIPLIIMSVVYAKIFFATkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepep 268
Cdd:cd15299 163 EPIITFGTAIAAFYLPVTIMTILYWRIYKET------------------------------------------------- 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lssradkpangisvhqfieekqrislSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFvtWLGYV 348
Cdd:cd15299 194 --------------------------IKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGY--WLCYI 245
                       330       340
                ....*....|....*....|....*.
gi 12229835 349 NSSLNPIIYTIYNKDFRTAFSRLLRC 374
Cdd:cd15299 246 NSTVNPVCYALCNKTFRTTFKMLLLC 271
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
38-368 1.47e-44

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 154.42  E-value: 1.47e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15309   6 LLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQK-RTIRRVNTMIAAVWALSLVISVPPLLGWNDwpaqfTEDTPCTLTQERlFVVYS 196
Cdd:cd15309  86 ASILNLCAISIDRYTAVAMPMLYNTRySSKRRVTVMISVVWVLSFAISCPLLFGLNN-----TDQNECIIANPA-FVVYS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 197 SSGSFFIPLIIMSVVYAKIFfatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradkp 276
Cdd:cd15309 160 SIVSFYVPFIVTLLVYVQIY------------------------------------------------------------ 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 277 angisvhqfieekqrISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqrVVDFVTWLGYVNSSLNPII 356
Cdd:cd15309 180 ---------------IVLQKEKKATQMLAIVLGVFIICWLPFFITHILNMHCDCNIPPA--LYSAFTWLGYVNSAVNPII 242
                       330
                ....*....|..
gi 12229835 357 YTIYNKDFRTAF 368
Cdd:cd15309 243 YTTFNIEFRKAF 254
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
44-368 3.20e-43

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 151.27  E-value: 3.20e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNL 123
Cdd:cd17790  12 LVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 124 CVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFT-EDTPCTLT--QERLFVVYSSSGS 200
Cdd:cd17790  92 LIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGERTvLAGQCYIQflSQPIITFGTAIAA 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 201 FFIPLIIMSVVYAKIFFATkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradkpangi 280
Cdd:cd17790 172 FYLPVTIMIILYWRIYRET------------------------------------------------------------- 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 281 svhqfieekqrislSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFvtWLGYVNSSLNPIIYTIY 360
Cdd:cd17790 191 --------------IKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPKTLWELGY--WLCYVNSTVNPMCYALC 254

                ....*...
gi 12229835 361 NKDFRTAF 368
Cdd:cd17790 255 NKSFRDTF 262
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
33-368 9.99e-42

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 147.10  E-value: 9.99e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15300   1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFT---EDTPCTLTQE 189
Cdd:cd15300  81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFVGKRTvpeRECQIQFLSE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIFFATkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepepl 269
Cdd:cd15300 161 PTITFGTAIAAFYIPVSVMTILYCRIYKET-------------------------------------------------- 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfieekqrislSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFvtWLGYVN 349
Cdd:cd15300 191 -------------------------IKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDCIPLTLWHLGY--WLCYVN 243
                       330
                ....*....|....*....
gi 12229835 350 SSLNPIIYTIYNKDFRTAF 368
Cdd:cd15300 244 STVNPMCYALCNKTFRKTF 262
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
44-368 2.38e-41

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 146.51  E-value: 2.38e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNL 123
Cdd:cd15301  12 LVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 124 CVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLFVVYSSSGS--- 200
Cdd:cd15301  92 LIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWPYIEGKRTVPAGTCYIQFLETNPYVTFGTala 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 201 -FFIPLIIMSVVYAKIFFATKRRlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradkpang 279
Cdd:cd15301 172 aFYVPVTIMCILYWRIWRETKKR--------------------------------------------------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 280 isvhqfiEEKQrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPF--CTNCAPpsQRVVDFVTWLGYVNSSLNPIIY 357
Cdd:cd15301 195 -------QKKQ------ESKAAKTLSAILLAFIVTWTPYNVLVLIKAFfpCSDTIP--TELWDFSYYLCYINSTINPLCY 259
                       330
                ....*....|.
gi 12229835 358 TIYNKDFRTAF 368
Cdd:cd15301 260 ALCNAAFRRTY 270
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
44-368 2.96e-40

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 143.18  E-value: 2.96e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNL 123
Cdd:cd15297  12 LVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 124 CVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFT-EDTPCTLT--QERLFVVYSSSGS 200
Cdd:cd15297  92 LIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTvPEGECYIQffSNAAVTFGTAIAA 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 201 FFIPLIIMSVVYAKIffatkrrlrertrklgtlavpappQRTSSRplaelesvasqedetepspepeplssradkpangi 280
Cdd:cd15297 172 FYLPVIIMTVLYWQI------------------------SRASSR----------------------------------- 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 281 svhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFvtWLGYVNSSLNPIIYTIY 360
Cdd:cd15297 193 ----------------EKKVTRTILAILLAFIITWTPYNVMVLINTFCASCIPNTVWTIGY--WLCYINSTINPACYALC 254

                ....*...
gi 12229835 361 NKDFRTAF 368
Cdd:cd15297 255 NATFKKTF 262
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
38-368 3.98e-38

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 138.53  E-value: 3.98e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAyrlLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15068   6 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT---ISTGFCAACHGCLFIACFVLVLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 -SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCT---------LT 187
Cdd:cd15068  83 qSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQgcgegqvacLF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 QERLFVVYSSSGSFF----IPLIIMSVVYAKIFFATKRRLRERTRKlgtlavpAPPqrtssrplaelesvasqedeteps 263
Cdd:cd15068 163 EDVVPMNYMVYFNFFacvlVPLLLMLGVYLRIFLAARRQLKQMESQ-------PLP------------------------ 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfiEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT 343
Cdd:cd15068 212 -----------------------GERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAI 268
                       330       340
                ....*....|....*....|....*
gi 12229835 344 WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15068 269 VLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
33-368 9.62e-38

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 137.34  E-value: 9.62e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQM--WLT 110
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIygFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 111 CdiLCCTSSILNLCVIALDRYWAITDPINYaQKRTIRRVNTMIAAVWALSLVISVPPLLGWN-------------DWPAQ 177
Cdd:cd14969  81 T--FLGLVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALPPLFGWSsyvpegggtscsvDWYSK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 178 FTEDTPCTLTqerLFVVysssgSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTlavpappqrtssrplaelesvasqe 257
Cdd:cd14969 158 DPNSLSYIVS---LFVF-----CFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNS------------------------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 258 detepspepeplssradkpangisvhqfieEKQRISLSKERKAARVLGVIMGVFVVCWLPfflmYAIVPFCTNCAPPSQr 337
Cdd:cd14969 205 ------------------------------AITKRTKKAEKKVAKMVLVMIVAFLIAWTP----YAVVSLYVSFGGEST- 249
                       330       340       350
                ....*....|....*....|....*....|....*....
gi 12229835 338 vvdfVTWLGYVNSSL--------NPIIYTIYNKDFRTAF 368
Cdd:cd14969 250 ----IPPLLATIPALfaksstiyNPIIYVFMNKQFRRAL 284
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
40-368 4.46e-37

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 135.44  E-value: 4.46e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15207   8 SLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPinYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQER--------- 190
Cdd:cd15207  88 VFTLVAIAVDRYRAVVHP--TEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVEFwpsdeyrka 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 ----LFVVYsssgsFFIPLIIMSVVYAKIffatkrrlrerTRKLGTLAVPAPPQRTSsrplaelesvasqedetepspep 266
Cdd:cd15207 166 yttsLFVLC-----YVAPLLIIAVLYVRI-----------GYRLWFKPVPGGGSASR----------------------- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangisvhqfieEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFcTNCAPPSQRVVD-----F 341
Cdd:cd15207 207 ---------------------EAQAAVSKKKVRVIKMLIVVVVLFALSWLPLHTVTMLDDF-GNLSPNQREVLYvyiypI 264
                       330       340
                ....*....|....*....|....*..
gi 12229835 342 VTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15207 265 AHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
43-367 7.63e-37

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 134.99  E-value: 7.63e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  43 ILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILN 122
Cdd:cd15318  11 MLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 123 LCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISvpPLLGWNDWP----AQFTEDTPCTLTQERLFVV---Y 195
Cdd:cd15318  91 LCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYT--SVFLYTKAVeeglAELLTSVPCVGSCQLLYNKlwgW 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLAvpappqrtssrplaelesvasqedetepspepeplssRADK 275
Cdd:cd15318 169 LNFPVFFIPCLIMIGLYVKIFIVAKRQARAIASLLSDTN-------------------------------------GASK 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 276 pangisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqrVVDFVTWLGYVNSSLNPI 355
Cdd:cd15318 212 --------------------RERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLNFITPPL--LFDIIIWFAYFNSACNPL 269
                       330
                ....*....|..
gi 12229835 356 IYTIYNKDFRTA 367
Cdd:cd15318 270 IYVFSYPWFRKA 281
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
36-368 2.54e-36

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 133.71  E-value: 2.54e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd14992   4 GVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgWNDWPAQFTEDTP-----CTL---- 186
Cdd:cd14992  84 VYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLY-YATTEVLFSVKNQekifcCQIppvd 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 --TQERLFVVYSSSGSFFIPLIIMSVVYAKIffatKRRLRERTrklgtlaVPappqrtssrplaelesvasqedetepsp 264
Cdd:cd14992 163 nkTYEKVYFLLIFVVIFVLPLIVMTLAYARI----SRELWFRK-------VP---------------------------- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpanGISvhqfIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPP--SQRVVDFV 342
Cdd:cd14992 204 --------------GFS----IKEVERKRLKCKRRVIKMLVCVVVLFVICWLPFHLFFLLRDFFPLIMKEkhTLQVYYFL 265
                       330       340
                ....*....|....*....|....*.
gi 12229835 343 TWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14992 266 HWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
37-372 4.81e-36

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 132.26  E-value: 4.81e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15295   5 FLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRT-IRRVNTMIAAVWALSLVISVPPLLGWNDWPaqfTEDTPCT--LTQERLFV 193
Cdd:cd15295  85 TASVYNIVLISYDRYQSVSNAVSYRNQQTaTLRIVTQMVAVWVLAFLVHGPAILVSDSWK---TEDGECEpeFFSNWYIL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 VYSSSGSFFIPLIIMSVVYAKIFFATKRRLRertrklgtlavpappqrtssrplaelesvasqedetepspepeplssra 273
Cdd:cd15295 162 AITSVLEFLVPVILVAYFNTQIYWSLWKRLR------------------------------------------------- 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 274 dkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNcaPPSQRVVDFVTWLGYVNSSLN 353
Cdd:cd15295 193 -----------------------DRKLAKSLAIILGTFAICWAPYSLFTIIRAACEK--HRGSPWYNFAFWLQWFNSFIN 247
                       330
                ....*....|....*....
gi 12229835 354 PIIYTIYNKDFRTAFSRLL 372
Cdd:cd15295 248 PFLYPLCHKRFRKAFLKIF 266
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
40-368 5.21e-36

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 132.01  E-value: 5.21e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15001   7 VITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQ--------ERL 191
Cdd:cd15001  87 VLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQkawpstlySRL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGSFFIPLIIMSVVYAKiffatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplss 271
Cdd:cd15001 167 YVVYLAIVIFFIPLIVMTFAYAR--------------------------------------------------------- 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpangisvhqfIEEKQRIslskerkaaRVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRV---VDFVTWLGYV 348
Cdd:cd15001 190 --------------DTRKQVI---------KMLISVVVLFAVCWGPLLIDNLLVSFDVISTLHTQALkymRIAFHLLSYA 246
                       330       340
                ....*....|....*....|
gi 12229835 349 NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15001 247 NSCINPIIYAFMSKNFRSSF 266
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
37-368 5.23e-35

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 129.48  E-value: 5.23e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAI-ILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQ-WLLGSYLCQMWLTCDIL 114
Cdd:cd15302   4 ALITAIlSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDyWPLGWVLCDLWLSVDYT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTE--DTPCT--LTQER 190
Cdd:cd15302  84 VCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFTGQGRSlpEGECYvqFMTDP 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 LFVVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepepls 270
Cdd:cd15302 164 YFNMGMYIGYYWTTLIVMLILYAGIYRAANR------------------------------------------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGYVNS 350
Cdd:cd15302 195 --------------------------ARKALRTITFILGAFVICWTPYHILATIYGFCEAPPCVNETLYTISYYLCYMNS 248
                       330
                ....*....|....*...
gi 12229835 351 SLNPIIYTIYNKDFRTAF 368
Cdd:cd15302 249 PINPFCYALANQQFKKTF 266
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
44-368 6.07e-35

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 129.37  E-value: 6.07e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNL 123
Cdd:cd15298  12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 124 CVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFT-EDTPCTLT--QERLFVVYSSSGS 200
Cdd:cd15298  92 LIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTvPDNQCFIQflSNPAVTFGTAIAA 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 201 FFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradkpangi 280
Cdd:cd15298 172 FYLPVVIMTVLYIHISLASAR----------------------------------------------------------- 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 281 svhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPpsQRVVDFVTWLGYVNSSLNPIIYTIY 360
Cdd:cd15298 193 ----------------ERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIP--DTVWSIGYWLCYVNSTINPACYALC 254

                ....*...
gi 12229835 361 NKDFRTAF 368
Cdd:cd15298 255 NATFKKTF 262
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
44-367 1.07e-34

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 129.21  E-value: 1.07e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNL 123
Cdd:cd15316  12 VLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 124 CVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL-GWNDWPAQFTEDT-----PCTLTQERLFVVYSS 197
Cdd:cd15316  92 CFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYtGVNDDGLEELVNAlncvgGCQIILNQNWVLVDF 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 198 SgSFFIPLIIMSVVYAKIFFATKRRLRertrklgtlavpappqrtssrplaELESVASQEDETEPSPepeplssradkpa 277
Cdd:cd15316 172 L-LFFIPTFAMIILYGKIFLVAKQQAR------------------------KIEMTSSKAESSSESY------------- 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 278 ngisvhqfieeKQRISlSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqrVVDFVTWLGYVNSSLNPIIY 357
Cdd:cd15316 214 -----------KDRVA-RRERKAAKTLGITVIAFLVSWLPYLIDVLIDAFMNFITPPY--IYEICCWCAYYNSAMNPLIY 279
                       330
                ....*....|
gi 12229835 358 TIYNKDFRTA 367
Cdd:cd15316 280 ALFYPWFRKA 289
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
37-368 1.35e-34

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 129.28  E-value: 1.35e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLlnQWLLGSYLCqMWLTCDILCC 116
Cdd:cd15069   5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISL--GFCTDFHSC-LFLACFVLVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 T-SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWND---------WPAQFTEDTPCTL 186
Cdd:cd15069  82 TqSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKamsatnnstNPADHGTNHSCCL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQ--------ERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLrertrklgtlavpappQRTSsrplaelesvasqed 258
Cdd:cd15069 162 ISclfenvvpMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQL----------------QRTE--------------- 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 259 etepspepeplssradkpangisvhqfIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQR- 337
Cdd:cd15069 211 ---------------------------LMDHSRTTLQREIHAAKSLAIIVGIFALCWLPVHILNCITLFQPEFSKSKPKw 263
                       330       340       350
                ....*....|....*....|....*....|.
gi 12229835 338 VVDFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15069 264 AMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
40-368 2.49e-34

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 128.49  E-value: 2.49e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15203   8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVSIFVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINyaQKRTIRRVNTMIAAVWALSLVISVPPLL-----------GWNDWPaQFTEDTPctltQ 188
Cdd:cd15203  88 TLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLAIfqelsdvpieiLPYCGY-FCTESWP----S 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ERLFVVYSSSGS---FFIPLIIMSVVYAKIFfatkRRLRERTRKLGTLavpapPQRTSSRplaelesvasqedetepspe 265
Cdd:cd15203 161 SSSRLIYTISVLvlqFVIPLLIISFCYFRIS----LKLRKRVKKKRGK-----RTLSSRR-------------------- 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 266 peplssradkpangisvhqfieekQRISLSKERKAARVLGVIMGVFVVCWLPF----FLMYAIVPFCTNcaPPSQRVVDF 341
Cdd:cd15203 212 ------------------------RRSELRRKRRTNRLLIAMVVVFAVCWLPLnlfnLLRDFEPLPQID--GRHFYLIFL 265
                       330       340
                ....*....|....*....|....*...
gi 12229835 342 VT-WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15203 266 IChLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
36-368 5.75e-34

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 127.47  E-value: 5.75e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVaYRLLNQ--WLLGSYLCQMWLTCDI 113
Cdd:cd14979   4 TAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVEL-YNFWWQypWAFGDGGCKLYYFLFE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgWND-------WPAQFTEDTPCTL 186
Cdd:cd14979  83 ACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILF-LMGiqylngpLPGPVPDSAVCTL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 T----QERLFVVYSSSGSFFIPLIIMSVVYAKIffATKRRlRERTRKLGTLAVPAPPQRTSsrplaelesvasqedetep 262
Cdd:cd14979 162 VvdrsTFKYVFQVSTFIFFVLPMFVISILYFRI--GVKLR-SMRNIKKGTRAQGTRNVELS------------------- 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvhqfieekqrISLSKERKAARVLGVIMGVFVVCWLPFF---LMYAIVP-FCTNCAPPSQRV 338
Cdd:cd14979 220 -----------------------------LSQQARRQVVKMLGAVVIAFFVCWLPFHaqrLMFSYASkEDTFLFDFYQYL 270
                       330       340       350
                ....*....|....*....|....*....|
gi 12229835 339 VDFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14979 271 YPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
41-368 1.20e-33

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 126.24  E-value: 1.20e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd15095   9 IIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQATC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 121 LNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL------GWNDWPAQFTEDTPCTLTQERLFVV 194
Cdd:cd15095  89 LTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIyyrleeGYWYGPQTYCREVWPSKAFQKAYMI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 195 YSSSGSFFIPLIIMSVVYAKIFfatkrrlrertRKLGTLAVPAPPQRTSSrplaelesvasqedetepspepeplssrad 274
Cdd:cd15095 169 YTVLLTYVIPLAIIAVCYGLIL-----------RRLWRRSVDGNNQSEQL------------------------------ 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 275 kpangisvhqfieekQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNcAPPSQRVVDFVTW---LGYVNSS 351
Cdd:cd15095 208 ---------------SERALRQKRKVTRMVIVVVVLFAICWLPNHVLNLWQRFDPN-FPETYATYALKIAalcLSYANSA 271
                       330
                ....*....|....*..
gi 12229835 352 LNPIIYTIYNKDFRTAF 368
Cdd:cd15095 272 VNPFVYAFMGENFRKYF 288
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
33-368 2.83e-33

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 125.10  E-value: 2.83e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADE-LFLLGLPFLATSYLLGYWPFGEVMCKIVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwPAQFTEDTP-CTL----- 186
Cdd:cd14970  80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFAR--TLQEEGGTIsCNLqwpdp 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 --TQERLFVVYSSSGSFFIPLIIMSVVYAKIFfatkRRLRertrklgtlavpappqrtSSRPLAELESvasqedetepsp 264
Cdd:cd14970 158 pdYWGRVFTIYTFVLGFAVPLLVITVCYSLII----RRLR------------------SSRNLSTSGA------------ 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpangisvhqfiEEKQRislsKERKAARVLGVIMGVFVVCWLPFFlMYAIVPFCTNcaPPSQRVV----D 340
Cdd:cd14970 204 ----------------------REKRR----ARRKVTRLVLVVVAVFVVCWLPFH-VFQIVRLLID--PPETLTVvgvfL 254
                       330       340
                ....*....|....*....|....*...
gi 12229835 341 FVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14970 255 FCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
37-365 3.71e-32

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 122.48  E-value: 3.71e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQM--WLTCDIL 114
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIvkYLQVVGL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILNLcvIALDRYWAITDPINYAQKRtiRRVNTMIAAVWALSLVISVPPL-------------LGWNDWPAQFted 181
Cdd:cd14986  85 FASTYILVS--MSLDRYQAIVKPMSSLKPR--KRARLMIVVAWVLSFLFSIPQLvifverelgdgvhQCWSSFYTPW--- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 182 tpctltQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTrklgtlAVPAPPQRTSSRplaelesvasqedete 261
Cdd:cd14986 158 ------QRKVYITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKT------DRPIAPTAMSCR---------------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 262 pspepeplssraDKPANGISVHQFIEEKQrislskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDF 341
Cdd:cd14986 210 ------------SVSCVSSRVSLISRAKI--------KTIKMTLVIILAFILCWTPYFIVQLLDVYAGMQQLENDAYVVS 269
                       330       340
                ....*....|....*....|....
gi 12229835 342 VTwLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd14986 270 ET-LASLNSALNPLIYGFFSSHLS 292
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
33-368 5.22e-32

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 121.44  E-value: 5.22e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15296   1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINY-AQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQ-FTEDTPC--TLTQ 188
Cdd:cd15296  81 YLLCTASVFNIVLISYDRFLSVTRAVSYrAQKGMTRQAVLKMVLVWVLAFLLYGPAIISWEYIAGGsIIPEGECyaEFFY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRlrertrklgtlavpappqrtssrplaelesvasqedetepspepep 268
Cdd:cd15296 161 NWYFLMTASTLEFFTPFISVTYFNLSIYLNIQKR---------------------------------------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lssradkpangisvhqfieekqRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCT-NCAPPSQRVVDFvtWLGY 347
Cdd:cd15296 195 ----------------------RFRLSRDKKVAKSLAIIVCVFGLCWAPYTLLMIIRAACHgHCVPDYWYETSF--WLLW 250
                       330       340
                ....*....|....*....|.
gi 12229835 348 VNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15296 251 VNSAINPVLYPLCHMSFRRAF 271
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
36-368 5.83e-32

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 122.02  E-value: 5.83e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15390   4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPInyaQKRTIRRVNTM-IAAVWALSLVISVPPLLgwndwpAQFTEDTPCTLTQER---- 190
Cdd:cd15390  84 VAASVFTLMAISIDRYIAIVHPL---RPRLSRRTTKIaIAVIWLASFLLALPQLL------YSTTETYYYYTGSERtvcf 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 ------------------LFVVysssgSFFIPLIIMSVVYAKIffatKRRLReRTRKLGTLAVpappqrtssrplAELES 252
Cdd:cd15390 155 iawpdgpnslqdfvynivLFVV-----TYFLPLIIMAVAYTRV----GVELW-GSKTIGENTP------------RQLES 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 253 VASQedetepspepeplssradkpangisvhqfieekqrislskeRKAARVLGVIMGVFVVCWLP---FFLMYAIVPFcT 329
Cdd:cd15390 213 VRAK-----------------------------------------RKVVKMMIVVVVIFAICWLPyhlYFILTYLYPD-I 250
                       330       340       350
                ....*....|....*....|....*....|....*....
gi 12229835 330 NCAPPSQRVVDFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15390 251 NSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
41-368 5.08e-30

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 116.73  E-value: 5.08e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd15195   9 VLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 121 LNLCVIALDRYWAITDPINYAQKRtiRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTED--TPC-------TLTQERL 191
Cdd:cd15195  89 FMLVVIALDRVFAILSPLSANQAR--KRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEQPgfHQCvdfgsapTKKQERL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRertrklgtlavpappqRTSSRPLAELESVASQedetepspepepLSS 271
Cdd:cd15195 167 YYFFTMILSFVIPLIITVTCYLLILFEISKMAK----------------RARDTPISNRRRSRTN------------SLE 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 RADKpangisvhqfieekqrislskerKAARVLGVIMGVFVVCWLPF---FLMYAIVPFCTNCAPPSQRVVDFVtwLGYV 348
Cdd:cd15195 219 RARM-----------------------RTLRMTALIVLTFIVCWGPYyvlGLWYWFDKESIKNLPPALSHIMFL--LGYL 273
                       330       340
                ....*....|....*....|
gi 12229835 349 NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15195 274 NPCLHPIIYGVFMKEIRNWI 293
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
38-368 7.56e-30

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 115.85  E-value: 7.56e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVlplnVAYRLLNQWLLGSYLCQMWL---TCDIL 114
Cdd:cd14972   4 VAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAF----VFTFLSVLLVSLTPSPATWLlrkGSLVL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpAQFTEDTPCT-----LTQE 189
Cdd:cd14972  80 SLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWN---CVLCDQESCSplgpgLPKS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVyssSGSFFIPLIIMSVVYAKIFFATKRRlrertrklgtlavpappqrtssrplaelesvasqedetepspepepl 269
Cdd:cd14972 157 YLVLI---LVFFFIALVIIVFLYVRIFWCLWRH----------------------------------------------- 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpANGISVHQfiEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCApPSQRVVDFVTWLGYVN 349
Cdd:cd14972 187 -------ANAIAARQ--EAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVC-DIQAVFYYFLVLALLN 256
                       330
                ....*....|....*....
gi 12229835 350 SSLNPIIYTIYNKDFRTAF 368
Cdd:cd14972 257 SAINPIIYAFRLKEMRRAV 275
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
36-228 9.51e-30

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 115.89  E-value: 9.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15083   4 GIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEdTPCTL------TQE 189
Cdd:cd15083  84 GIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLL-TSCSFdylsrdDAN 162
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTR 228
Cdd:cd15083 163 RSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKE 201
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
37-368 1.36e-29

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 115.95  E-value: 1.36e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15208   5 ALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYaqKRTIRRVNTMIAAVWALSLVISVPPLL-----GWNDWPAQFTEDTPC--TLTQE 189
Cdd:cd15208  85 SVSVLTLSCIALDRWYAICHPLMF--KSTAKRARVSILIIWIVSLLIMIPQAIvmecsRVVPLANKTILLTVCdeRWSDS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSS---GSFFIPLIIMSVVYAKIFfatkrrlrertRKLGTLAVPaPPQRTSSRPLaelesvasqedetepspep 266
Cdd:cd15208 163 IYQKVYHICfflVTYLLPLCLMILAYFQIF-----------RKLWCRQIP-GTSSVVQRKW------------------- 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssraDKPANGiSVHQfiEEKQrisLSKERKAARVLGVIMGVFVVCWLPFFLM----YAIVPFCTNcappSQRVVDFV 342
Cdd:cd15208 212 -------NKPRKS-AVAA--EEKQ---LRSRRKTAKMLIVVVIMFAICYLPVHLLnilrYVFGLFTVD----RETIYAWF 274
                       330       340
                ....*....|....*....|....*....
gi 12229835 343 T---WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15208 275 LfshWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
34-368 5.69e-29

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 113.62  E-value: 5.69e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLR-SVQNFFVVSLAVADLTVALFVlPLNVAYRLLNQWLLG-SYLCQMWLTC 111
Cdd:cd15104   1 AAGVILAVLSPLIITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAI-PGLATDELLSDGENTqKVLCLLRMCF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgwNDWPAQFTEDTPCTLTQE-- 189
Cdd:cd15104  80 VITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLI--SPQFQQTSYKGKCSFFAAfh 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLAVPAPPQRTSSRPlaelesvasqedetepspepepl 269
Cdd:cd15104 158 PRVLLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHPRRTLSDF----------------------- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfieekqrislskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCApPSQRVVDFVTWLGYVN 349
Cdd:cd15104 215 -----------------------------KAARTVAVLIGCFLLSWLPFQITGLVQALCDECK-LYDVLEDYLWLLGLCN 264
                       330
                ....*....|....*....
gi 12229835 350 SSLNPIIYTIYNKDFRTAF 368
Cdd:cd15104 265 SLLNPWIYAFWQKEVRRAL 283
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
37-367 1.55e-27

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 109.81  E-value: 1.55e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15336   5 SVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDW-PAQFTedTPCTL------TQE 189
Cdd:cd15336  85 ITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYvPEGLL--TSCTWdymtftPSV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRErTRKLGTLAVpappQRTSsrplaelesvasqedetepspepepl 269
Cdd:cd15336 163 RAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGRE-VQKLGSQDR----KEKA-------------------------- 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfieeKQRISLSKERKAARVLGVIMGVFVVCWLPfflmYAivpfctncappsqrVVDFVTWLGYVN 349
Cdd:cd15336 212 -------------------KQYQRMKNEWKMAKIAFVVILLFVLSWSP----YA--------------CVALIAWAGYAH 254
                       330       340       350
                ....*....|....*....|....*....|....*
gi 12229835 350 ----------------SSL-NPIIYTIYNKDFRTA 367
Cdd:cd15336 255 lltpymksvpaviakaSAIyNPIIYAITHPKYREA 289
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
42-368 1.97e-27

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 109.69  E-value: 1.97e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15096  10 IFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTED--TPCTLTQERLFVVYSSSG 199
Cdd:cd15096  90 TLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEaySYCTFLTEVGTAAQTFFT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 200 SFF-----IPLIIMSVVYAKIFFatkrRLRERtrklgtlavpappQRTSSRPLAElesvasqedetepspepeplssrad 274
Cdd:cd15096 170 SFFlfsylIPLTLICVLYMLMLR----RLRRQ-------------KSPGGRRSAE------------------------- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 275 kpangisvhqfieekqriSLSKERKAARVLGVIMGVFVVCWLP----FFLMYAIVPFCTncaPPSQRVVDFVTWLGYVNS 350
Cdd:cd15096 208 ------------------SQRGKRRVTRLVVVVVVVFAICWLPihiiLLLKYYGVLPET---VLYVVIQILSNCLAYGNS 266
                       330
                ....*....|....*...
gi 12229835 351 SLNPIIYTIYNKDFRTAF 368
Cdd:cd15096 267 CVNPILYAFLSQNFRKAF 284
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
37-368 2.04e-27

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 109.48  E-value: 2.04e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd14971   5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLT-----QERL 191
Cdd:cd14971  85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSEAwpsraHRRA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGSFFIPLIIMSVVYAKIFfatkrrlrertRKLGTLAVPAPPQRTSSRplaelesvasqedetepspepeplss 271
Cdd:cd14971 165 FALCTFLFGYLLPLLLICVCYAAML-----------RHLWRVAVRPVLSEGSRR-------------------------- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpangisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFctNCAPPSQRVVDFVTW---LGYV 348
Cdd:cd14971 208 ------------------------AKRKVTRLVLVVVVLFAACWGPIHAILLLVAL--GPFPLTYATYALRIWahcLAYS 261
                       330       340
                ....*....|....*....|
gi 12229835 349 NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14971 262 NSAVNPVLYAFLSEHFRKAF 281
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
38-365 7.95e-27

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 107.75  E-value: 7.95e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15074   6 YLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPiNYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDW-PAQFteDTPCTL--------TQ 188
Cdd:cd15074  86 CSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYgPEPF--GTSCSIdwtgasasVG 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ERLFVVYSSSGSFFIPLIIMSVVYAKIFFaTKRRLRERTRKLGTLavpaPPQRTSSrplaelesvasqedetepspepep 268
Cdd:cd15074 163 GMSYIISIFIFCYLLPVLIIVFSYVKIIR-KVKSSRKRVAGFDSR----SKRQHKI------------------------ 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPfflmYAIVPFCTNCAPPSQrVVDFVTWLGYV 348
Cdd:cd15074 214 ----------------------------ERKVTKVAVLICAGFLIAWTP----YAVVSMWSAFGSPDS-VPILASILPAL 260
                       330       340
                ....*....|....*....|.
gi 12229835 349 ----NSSLNPIIYTIYNKDFR 365
Cdd:cd15074 261 faksSCMYNPIIYLLFSSKFR 281
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
33-368 1.18e-26

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 107.76  E-value: 1.18e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLP-----LNVAYrllnQWLLGSYLCQM 107
Cdd:cd14997   1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPvalveTWARE----PWLLGEFMCKL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 108 WLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL-------GWNDWPAQFTE 180
Cdd:cd14997  77 VPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFitefkeeDFNDGTPVAVC 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 181 DTPCTLTQERLFVVYSSSGSFFIPLIIMSVVYAKIffatKRRLRERtrklgtlavPAPPQRTSSRplaelesvasqedet 260
Cdd:cd14997 157 RTPADTFWKVAYILSTIVVFFVVPLAILSGLYSVI----CRRLVGH---------PALESRRADA--------------- 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 261 epspepeplssradkpangisvhqfieeKQRISLSKERKAARVLGVIMGVFVVCWLPF--FLMYAIVpfctncAPPSQ-- 336
Cdd:cd14997 209 ----------------------------ANRHTLRSRRQVVYMLITVVVLFFVCLLPFrvVTLWIIF------APDEDlq 254
                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 12229835 337 --------RVVDFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14997 255 alglegylNLLVFCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
39-359 2.08e-26

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 106.89  E-value: 2.08e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  39 LLAII-----LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15079   2 LLGFIyiflgIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLM-MIKMPIFIYNSFYEGWALGPLGCQIYAFLGS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINyAQKRTIRRVNTMIAAVWALSLVISVPPLL-GWNdwpaQFTED---TPCT---L 186
Cdd:cd15079  81 LSGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALLPLLfGWG----RYVPEgflTSCSfdyL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQE---RLFVVYSSSGSFFIPLIIMSVVYAKIF---FATKRRLRERTRKLGTlavpappqrTSSRPLAELESVasqedet 260
Cdd:cd15079 156 TRDwntRSFVATIFVFAYVIPLIIIIYCYSFIVkavFAHEKALREQAKKMNV---------VSLRSNADANKQ------- 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 261 epspepeplssradkpangisvhqfieekqrislSKERKAARVLGVIMGVFVVCWLPfflmYAIVPFcTNCAPPSQRVVD 340
Cdd:cd15079 220 ----------------------------------SAEIRIAKVALTNVFLWFIAWTP----YAVVAL-IGAFGNQSLLTP 260
                       330       340
                ....*....|....*....|...
gi 12229835 341 FVTWLGYV----NSSLNPIIYTI 359
Cdd:cd15079 261 LVSMIPALfaktAACYNPIVYAI 283
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
42-368 4.39e-26

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 106.05  E-value: 4.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15202  10 IIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINyaQKRTIRRVNTMIAAVWALSLVISVP-PLLGWNDWPAQFT--------EDTPC-TLTQERL 191
Cdd:cd15202  90 TLTAIAVDRYQAIMHPLK--PRISKTKAKFIIAVIWTLALAFALPhAICSKLETFKYSEdivrslclEDWPErADLFWKY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGSFFIPLIIMSVVYAKIffatkrrlrerTRKLgtlavpappqrTSSRPLAELESvasqedetepspepeplss 271
Cdd:cd15202 168 YDLALFILQYFLPLLVISFAYARV-----------GIKL-----------WASNMPGDATT------------------- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpangisvhqfiEEKQRIsLSKERKAARVLGVIMGVFVVCWLPF---FLMYAIVPFctNCAPPSQRVVDFVTWLGYV 348
Cdd:cd15202 207 ---------------ERYFAL-RRKKKKVIKMLMVVVVLFALCWLPFniyVLLLSSKPD--YLIKTINAVYFAFHWLAMS 268
                       330       340
                ....*....|....*....|
gi 12229835 349 NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15202 269 STCYNPFIYCWLNERFRIEF 288
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
37-368 6.23e-26

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 105.57  E-value: 6.23e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAII-LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15393   4 SILYGIIsLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINyaQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpAQFTEDTPCTLTQERLFVVY 195
Cdd:cd15393  84 VNVSVFTLTVIAVDRYRAVIHPLK--ARCSKKSAKIIILIIWILALLVALPVALALR---VEELTDKTNNGVKPFCLPVG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSG------------SFFIPLIIMSVVYAKIffatkrrlrerTRKLGTLAVPAPPQRTssrplaelesvasqedeteps 263
Cdd:cd15393 159 PSDDwwkiynlylvcvQYFVPLVIICYAYTRI-----------AVKIWGTKAPGNAQDV--------------------- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfieEKQRISLSKeRKAARVLGVIMGVFVVCWLP---FFLMYAIVP------------FC 328
Cdd:cd15393 207 ------------------------RDDEILKNK-KKVIKMLIIVVALFALCWLPlqtYNLLNEIKPeinkykyiniiwFC 261
                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 12229835 329 TNcappsqrvvdfvtWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15393 262 SH-------------WLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
42-368 8.15e-26

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 105.31  E-value: 8.15e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLgsYLCQMwLTCDILCCT-SSI 120
Cdd:cd15071  10 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEF--YSCLM-VACPVLILTqSSI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 121 LNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWND-------WPAQFTEDTPCTLTQERLFV 193
Cdd:cd15071  87 LALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNlnaveraWAANSSMGELVIKCQFETVI 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 V--YSSSGSFFI----PLIIMSVVYAKIFFATKRRLRERtrklgtlavpappqrtssrplaelesvasqedetepspepe 267
Cdd:cd15071 167 SmeYMVYFNFFVwvlpPLLLMLLIYLEVFYLIRKQLNKK----------------------------------------- 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 268 plssradkpangISVHqfiEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQrVVDFVTWLGY 347
Cdd:cd15071 206 ------------VSSS---SSDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCKKPMI-LTYIAIFLTH 269
                       330       340
                ....*....|....*....|.
gi 12229835 348 VNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15071 270 GNSAMNPIVYAFRIKKFRTTF 290
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
40-368 8.68e-26

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 104.88  E-value: 8.68e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADlTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15972   8 LVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFTS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIsVPPLLGWNDWPAQFTE-----DTPCTLTQERlFVV 194
Cdd:cd15972  87 IFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLV-VLPVVIFSGVPGGMGTchiawPEPAQVWRAG-FII 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 195 YSSSGSFFIPLIIMSVVYAKIFFatkrrlreRTRKLGTLAVPAPPQRTSSrplaelesvasqedetepspepeplssrad 274
Cdd:cd15972 165 YTATLGFFCPLLVICLCYLLIVV--------KVRSSGRRVRATSTKRRGS------------------------------ 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 275 kpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPS-QRVVDFVTWLGYVNSSLN 353
Cdd:cd15972 207 ----------------------ERKVTRMVVIVVAAFVLCWLPFYALNIVNLVCPLPEEPSlFGLYFFVVVLSYANSCAN 264
                       330
                ....*....|....*
gi 12229835 354 PIIYTIYNKDFRTAF 368
Cdd:cd15972 265 PIIYGFLSDNFKQGF 279
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
33-365 1.13e-25

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 105.14  E-value: 1.13e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLaiiLVTIVGNSLVIISVFTYRPLRSVQ-NFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTC 111
Cdd:cd15383   4 VAVTFVLF---VLSACSNLAVLWSATRNRRRKLSHvRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRtiRRVNTMIAAVWALSLVISVPPLLGWN----DWPAQFTEdtpCTLT 187
Cdd:cd15383  81 KLFAMYSSAFVTVVISLDRHAAILNPLAIGSAR--RRNRIMLCAAWGLSALLALPQLFLFHtvtaTPPVNFTQ---CATH 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 -------QERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTrklgtlavpappqrtssrplaelesvasqedet 260
Cdd:cd15383 156 gsfpahwQETLYNMFTFFCLFLLPLLIMIFCYTRILLEISRRMKEKK--------------------------------- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 261 epspepeplssraDKPANGISVHqfieeKQRISLSKER-KAARVLGVIMGVFVVCWLPFFLM---YAIVP-FCTNCAPPS 335
Cdd:cd15383 203 -------------DSAKNEVALR-----SSSDNIPKARmRTLKMTIVIVSSFIVCWTPYYLLglwYWFSPeMLEQTVPES 264
                       330       340       350
                ....*....|....*....|....*....|
gi 12229835 336 QRVVDFVtwLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15383 265 LSHILFL--FGLLNACLDPLIYGLFTISFR 292
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
42-368 2.97e-25

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 103.65  E-value: 2.97e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPL--RSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15098  10 IFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL---------------LGWNDWPAQftedtpc 184
Cdd:cd15098  90 IFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAvhqdlvhhwtasnqtFCWENWPEK------- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 185 tlTQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKlgtlavpappqrtssrplaelesvasqedetepsp 264
Cdd:cd15098 163 --QQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKLKNMSKK----------------------------------- 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpangisvhqfieekqriSLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT- 343
Cdd:cd15098 206 ----------------------------SERSKKKTAQTVLVVVVVFGISWLPHHIIHLWVEFGDFPLTQASFVLRITAh 257
                       330       340
                ....*....|....*....|....*
gi 12229835 344 WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15098 258 CLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-368 4.63e-25

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 102.93  E-value: 4.63e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADltvALFVL--PLNVAYRLLNQWLLGSYLCQMWLT 110
Cdd:cd15093   1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIAD---ELFMLglPFLAASNALRHWPFGSVLCRLVLS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 111 CDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIsVPPLLGWNDWPAQFTEDTPCTLTQER 190
Cdd:cd15093  78 VDGINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLV-ILPVVVFAGTRENQDGSSACNMQWPE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 -------LFVVYSSSGSFFIPLIIMSVVYAKIFfatkRRLRERTRKLGTlavpapPQRTSSrplaelesvasqedeteps 263
Cdd:cd15093 157 paaawsaGFIIYTFVLGFLLPLLIICLCYLLIV----IKVKSAGLRAGW------QQRKRS------------------- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQR-VVDFV 342
Cdd:cd15093 208 ---------------------------------ERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQLPETPALVgVYHFV 254
                       330       340
                ....*....|....*....|....*.
gi 12229835 343 TWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15093 255 VILSYANSCANPILYGFLSDNFKKSF 280
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
33-366 1.03e-24

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 101.91  E-value: 1.03e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtvaLFVLPLNV-AYRLLNQWLLGSYLCQMWLTC 111
Cdd:cd14984   1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADL---LFVLTLPFwAVYAADGWVFGSFLCKLVSAL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL------GWNDWPAQFTEDTPCT 185
Cdd:cd14984  78 YTINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIfsqvseENGSSICSYDYPEDTA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 186 LTQERLFVVYSSSGSFFIPLIIMSVVYAKIFfatkRRLRertrklgtlavpappqrtssrplaelesvasqedetepspe 265
Cdd:cd14984 158 TTWKTLLRLLQNILGFLLPLLVMLFCYSRII----RTLL----------------------------------------- 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 266 peplssradkpangisvhqfieekqRISLSKERKAARVLGVIMGVFVVCWLPF---------FLMYAIVPFCtncapPSQ 336
Cdd:cd14984 193 -------------------------RARNHKKHRALRVIFAVVVVFFLCWLPYnivllldtlQLLGIISRSC-----ELS 242
                       330       340       350
                ....*....|....*....|....*....|....
gi 12229835 337 RVVDF---VTW-LGYVNSSLNPIIYTIYNKDFRT 366
Cdd:cd14984 243 KSLDYalqVTEsLAFSHCCLNPVLYAFVGVKFRK 276
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
41-368 1.23e-24

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 102.05  E-value: 1.23e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLN-VAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15392   9 TIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSfIALLILQYWPFGEFMCPVVNYLQAVSVFVS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINyaQKRTIRRVNTMIAAVWALSLVISVP-PLLGWNDWPAQFTEDTP-CTLTQERLFV--VY 195
Cdd:cd15392  89 AFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATALPiAITSRLFEDSNASCGQYiCTESWPSDTNryIY 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSG---SFFIPLIIMSVVYAKIffaTKRRLRERTrklgtlavpaPPQRTSSRplaelesvasqedetepspepeplssr 272
Cdd:cd15392 167 SLVLmilQYFVPLAVLVFTYTRI---GIVVWAKRT----------PGEAENNR--------------------------- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhqfieeKQRISLSKeRKAARVLGVIMGVFVVCWLPF-FLMYAIVPFCT-NCAPPSQRVVDFVTWLGYVNS 350
Cdd:cd15392 207 ----------------DQRMAESK-RKLVKMMITVVAIFALCWLPLnILNLVGDHDESiYSWPYIPYLWLAAHWLAMSHC 269
                       330
                ....*....|....*...
gi 12229835 351 SLNPIIYTIYNKDFRTAF 368
Cdd:cd15392 270 CYNPFIYCWMNAKFRNGF 287
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
33-367 6.66e-24

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 99.87  E-value: 6.66e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVaYRLLN--QWLLGSYLCQMWLT 110
Cdd:cd15928   1 AAVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLI-FLVLPLDL-YRLWRyrPWRFGDLLCRLMYF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 111 CDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL--GWNDWPAQFTEDT-PCTLT 187
Cdd:cd15928  79 FSETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVlvGVEHIQGQQTPRGfECTVV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 QERL----FVVYSSSGSFFIPLIIMSVVYAKIffatKRRLRERTRKLGTLAvpappqrtssrplaelesvASQEDEteps 263
Cdd:cd15928 159 NVSSgllsVMLWVSTSFFFVPMVCLSLLYGLI----GRALWDRRQRSRTAG-------------------ASRRDN---- 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT 343
Cdd:cd15928 212 --------------------------------NHRQTVRMLAVIVLAFVLCWLPFHVGRVIFNHSRASTKHLHYVSQYFN 259
                       330       340
                ....*....|....*....|....*...
gi 12229835 344 WLG----YVNSSLNPIIYTIYNKDFRTA 367
Cdd:cd15928 260 LVSfvlfYLSAAINPILYNLMSKRYRYA 287
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
36-365 7.51e-24

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 99.90  E-value: 7.51e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15391   4 INLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINyaQKRTIRRVNTMIAAVWALSLVIS-VPPLLGWNDWPAQFTEDT-------PCTLT 187
Cdd:cd15391  84 VTASVLTNTAIGIDRFFAVIFPLR--SRHTKSRTKCIIASIWAISFSLSsVQLFAGRTQRYGQYSEGRvlcgeswPGPDT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 QERLFVVYSSSGSFFIPLIIMSVVYAKIffatKRRLRERTrklgtlavpappqrtssrplaelesvasqedetepspepe 267
Cdd:cd15391 162 SRSAYTVFVMLLTYIIPLLILTSTYGYV----GFRLWNRT---------------------------------------- 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 268 plssradKPANGisvhqfIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT---- 343
Cdd:cd15391 198 -------APGNA------DKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRNMPQHTTRLIYgach 264
                       330       340
                ....*....|....*....|..
gi 12229835 344 WLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15391 265 WIAMSNSFVNPIIYLFMNDSFR 286
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
41-368 1.26e-23

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 99.08  E-value: 1.26e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLlnQWLLGSYLCqMWLTCDILCCT-SS 119
Cdd:cd15070   9 LIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSL--GVTIHFYSC-LFMSCLLVVFThAS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPA---QFTEDTPCTLTQErLFVVYS 196
Cdd:cd15070  86 IMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSlesVNTTPLQCQFTSV-MRMDYM 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 197 SSGSFF----IPLIIMSVVYAKIFFATKRRLRERTrklgtlavpappqrTSSRplaelesvasqedetepspepeplssr 272
Cdd:cd15070 165 VYFSFFtwilIPLVIMCALYVDIFYIIRNKLSQNA--------------TGFR--------------------------- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhqfieeKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFvtwLGYVNSSL 352
Cdd:cd15070 204 ----------------ETGAFYGREFKTAKSLALVLFLFAVCWLPLSIINCVVYFNPKVPKIALYLGIL---LSHANSMM 264
                       330
                ....*....|....*.
gi 12229835 353 NPIIYTIYNKDFRTAF 368
Cdd:cd15070 265 NPIVYACKIKKFKETY 280
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
35-368 1.41e-23

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 98.93  E-value: 1.41e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAII-LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFV-LPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15337   2 LIGIYIAIVgILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgFPLKTISSFNKKWIWGKVACELYGFAG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDW-PAQFteDTPCT---LTQ 188
Cdd:cd15337  82 GIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYvPEGF--QTSCTfdyLSR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 E---RLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTrklgtlavpappQRTSSRPLAELESVasqedetepspe 265
Cdd:cd15337 160 DlnnRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEKEMT------------QTAKSGMGKDTEKN------------ 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 266 peplssRADKPAngisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPfflmYAIVPFCTnCAPPSQRVVDFVTWL 345
Cdd:cd15337 216 ------DARKKA-------------------EIRIAKVAIILISLFLLSWTP----YAVVALLG-QFGPAYWITPYVSEL 265
                       330       340
                ....*....|....*....|....*..
gi 12229835 346 GYV---NSSL-NPIIYTIYNKDFRTAF 368
Cdd:cd15337 266 PVMfakASAIyNPIIYALSHPKFRAAL 292
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
37-368 4.89e-23

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 97.72  E-value: 4.89e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15927   5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP----------------PLLGWNDWPAQFTE 180
Cdd:cd15927  85 GVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPeaifshvvtftltdnqTIQICYPYPQELGP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 181 DTPCTLTQERlFVVYsssgsFFIPLIIMSVVYAKIffatKRRLRERTRKLGTLAVPAPPQRTSSRplaelesvasqedet 260
Cdd:cd15927 165 NYPKIMVLLR-FLVY-----YLIPLLIIGVFYVLM----ARHLIRSTRNIGSGQNQAAQRQIEAR--------------- 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 261 epspepeplssradkpangisvhqfieekqrislskeRKAARVLGVIMGVFVVCWLP---FFLMYAIVPfcTNCAPPSQ- 336
Cdd:cd15927 220 -------------------------------------KKVAKTVLAFVVLFAVCWLPrhvFMLWFHFAP--NGLVDYNAf 260
                       330       340       350
                ....*....|....*....|....*....|....*.
gi 12229835 337 ----RVVDFVtwLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15927 261 whvlKIVGFC--LSFINSCVNPVALYLLSGSFRRHF 294
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
36-367 4.91e-23

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 97.05  E-value: 4.91e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15213   4 AILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAItdpINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWpaQFTEDTP-CTL-----TQE 189
Cdd:cd15213  84 VLEGVAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKY--EFPPRAPqCVLgytesPAD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYakifFATKRRLRE-RTRKLGTLAVpappqrtssrplaelesvasqedetepspepep 268
Cdd:cd15213 159 RIYVVLLLVAVFFIPFLIMLYSY----FCILNTVRSfKTRAFTTILI--------------------------------- 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lssradkpangisvhQFIeekqrislskerkaarvlgvimgVFVVCWLPfFLMYAIVPFCTNCAPPSQRVVDFVTWLGYV 348
Cdd:cd15213 202 ---------------LFI-----------------------GFSVCWLP-YTVYSLLSVFSRYSSSFYVISTCLLWLSYL 242
                       330
                ....*....|....*....
gi 12229835 349 NSSLNPIIYTIYNKDFRTA 367
Cdd:cd15213 243 KSAFNPVIYCWRIKKFREA 261
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
33-368 8.98e-23

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 96.31  E-value: 8.98e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15206   1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLT----- 187
Cdd:cd15206  81 AVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGGHKCREVwpnei 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 QERLFVVYSSSGSFFIPLIIMSVVYAKIffatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepe 267
Cdd:cd15206 161 AEQAWYVFLDLMLLVIPGLVMSVAYGLI---------------------------------------------------- 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 268 plssradkpangisVHQFIEEKQRIslskerkaARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPP--SQRVVDFVTWL 345
Cdd:cd15206 189 --------------SWTLLEAKKRV--------IRMLFVIVVEFFICWTPLYVINTWKAFDPPSAARyvSSTTISLIQLL 246
                       330       340
                ....*....|....*....|...
gi 12229835 346 GYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15206 247 AYISSCVNPITYCFMNKRFRQAF 269
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
35-368 1.32e-22

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 95.41  E-value: 1.32e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDIL 114
Cdd:cd15210   3 AAVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLG-WNDWpaQFTEDT-PCTLTQER-- 190
Cdd:cd15210  83 LVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGiWGRF--GLDPKVcSCSILRDKkg 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 ------LFVVYsssgsFFIPLIIMSVVYAkiffatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepsp 264
Cdd:cd15210 161 rspktfLFVFG-----FVLPCLVIIICYA--------------------------------------------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpangisvhqfieekqrisLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPfctNCAPPSQRVVDFVtw 344
Cdd:cd15210 185 -----------------------------RREDRRLTRMMLVIFLCFLVCYLPITLVNVFDD---EVAPPVLHIIAYV-- 230
                       330       340
                ....*....|....*....|....
gi 12229835 345 LGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15210 231 LIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
33-357 1.55e-22

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 96.35  E-value: 1.55e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15384   1 LLKIVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPInyAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTED-TPCT------ 185
Cdd:cd15384  81 VFGLYLSTYITVLISLDRCVAILYPM--KRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDfHQCVtygfyt 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 186 -LTQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRErTRKLGTLAVPAPPQRtssrplaelesvasqedetepsp 264
Cdd:cd15384 159 aEWQEQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRD-FQGLEIYTRNRGPNR----------------------- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpangisvhqfieekQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFcTNCAPPSQRVVDFVTW 344
Cdd:cd15384 215 -------------------------QRLFHKAKVKSLRMSAVIVTAFILCWTPYYVIMIWFLF-FNPYPLNDILFDVIFF 268
                       330
                ....*....|...
gi 12229835 345 LGYVNSSLNPIIY 357
Cdd:cd15384 269 FGMSNSCVNPLIY 281
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
33-365 2.33e-22

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 95.41  E-value: 2.33e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRL-LNQWLLGSYLCQmwLTC 111
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVL-TLPFRIYYYLnGGWWPFGDFLCR--LTG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCT--SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFT-----EDTPC 184
Cdd:cd14982  78 LLFYINmyGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNsttcfEFLSE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 185 TLTQERLFVVYSSSGSFFIPLIIMSVVYAKIffatkrrlrertrkLGTLAVPAPPQRTSSRplaelesvasqedetepsp 264
Cdd:cd14982 158 WLASAAPIVLIALVVGFLIPLLIILVCYSLI--------------IRALRRRSKQSQKSVR------------------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPF---FLMYAIVPFCTNCAPPSQRVVDF 341
Cdd:cd14982 205 --------------------------------KRKALRMILIVLAVFLVCFLPYhvtRILYLLVRLSFIADCSARNSLYK 252
                       330       340
                ....*....|....*....|....*...
gi 12229835 342 V----TWLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd14982 253 AyritLCLASLNSCLDPLIYYFLSKTFR 280
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
42-235 4.23e-22

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 94.82  E-value: 4.23e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15012   9 VFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCtltqERLFVVYSSSGS- 200
Cdd:cd15012  89 ILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQE----EEICVLDREMFNs 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 12229835 201 -----------FFIPLIIMSVVYAKIFFATKRRLR-ERTRKLGTLAV 235
Cdd:cd15012 165 klydtinfivwYLIPLLIMTVLYSKISIVLWKSSSiEARRKVVRLLV 211
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
33-368 7.27e-22

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 94.10  E-value: 7.27e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFvLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15974   1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLG-LPFLATQNAISYWPFGSFLCRLVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL------GWNDWPAQFTEDTPCTL 186
Cdd:cd15974  80 GVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIfsdvqpDLNTCNISWPEPVSVWS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TqerLFVVYSSSGSFFIPLIIMSVVYAKIFFATKrrlRERTRKLGTlavpappqrtssrplaelesvasqedetepspep 266
Cdd:cd15974 160 T---AFIIYTAVLGFFGPLLVICLCYLLIVIKVK---SSGLRVGST---------------------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangisvhqfieeKQRISlskERKAARVLGVIMGVFVVCWLPFFLMYAI-VPFCTNCAPPSQRVVDFVTWL 345
Cdd:cd15974 200 ----------------------KRRKS---ERKVTRMVVIIVVVFVFCWLPFYMLNIVnLIVILPEEPAFVGVYFFVVVL 254
                       330       340
                ....*....|....*....|...
gi 12229835 346 GYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15974 255 SYANSCANPILYGFLSDNFKQSF 277
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
37-365 7.35e-22

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 94.30  E-value: 7.35e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQ-NFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15382   5 IVYSVLFLIAAVGNLTVLLILLRNRRRKRSRvNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRtiRRVNTMIAAVWALSLVISVPPLLGWN-------DWPAQ-FTEDTPCTLT 187
Cdd:cd15382  85 LYLSSFVLVCISLDRYFAILKPLRLSDAR--RRGRIMLAVAWVISFLCSIPQSFIFHveshpcvTWFSQcVTFNFFPSHD 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 QERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLAVPAPPQRTSsrplaelesvasqedetepspepe 267
Cdd:cd15382 163 HELAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSEKSSSVRLRRSS------------------------ 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 268 plssradkpangisvhQFIEEKQRIslskerKAARVLGVIMGVFVVCWLPFFLMyAIVPFC--TNCAPPSQRVVDFVTWL 345
Cdd:cd15382 219 ----------------VGLLERARS------RTLKMTIVIVLVFIICWTPYFIM-SLWYWFdrESASKVDPRIQKGLFLF 275
                       330       340
                ....*....|....*....|
gi 12229835 346 GYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15382 276 AVSNSCMNPIVYGYFSIDLR 295
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
42-368 2.03e-21

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 92.67  E-value: 2.03e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVlPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15970  10 VCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSV-PFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIY 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQE------RLFVVY 195
Cdd:cd15970  89 CLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVACNMQMPEpsqrwlAVFVVY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSFFIPLIIMSVVYakIFFATKRRLrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssradk 275
Cdd:cd15970 169 TFLMGFLLPVIAICLCY--ILIIVKMRV---------------------------------------------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 276 pangISVHQFIEEKQRislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNcapPSQRVVDFVTWLGYVNSSLNPI 355
Cdd:cd15970 195 ----VALKAGWQQRKR----SERKITLMVMMVVTVFVICWMPFYVVQLVSVFVGQ---HDATVSQLSVILGYANSCANPI 263
                       330
                ....*....|...
gi 12229835 356 IYTIYNKDFRTAF 368
Cdd:cd15970 264 LYGFLSDNFKRSF 276
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
36-368 2.24e-21

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 92.60  E-value: 2.24e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADlTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15971   4 TFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIAD-ELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGIN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQftEDTPCTL-------TQ 188
Cdd:cd15971  83 QFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKH--GRSSCTIiwpgessAW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepep 268
Cdd:cd15971 161 YTGFIIYTFILGFFVPLTIICLCYLFIIIKVK------------------------------------------------ 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lssradkpANGISVHQFIEEKQrislskERKAARVLGVIMGVFVVCWLPFFLMYAI-VPFCTNCAPPSQRVVDFVTWLGY 347
Cdd:cd15971 193 --------SSGIRVGSSKRKKS------EKKVTRMVSIVVAVFVFCWLPFYIFNVSsVSVSISPTPGLKGMFDFVVVLSY 258
                       330       340
                ....*....|....*....|.
gi 12229835 348 VNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15971 259 ANSCANPILYAFLSDNFKKSF 279
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
37-367 3.90e-21

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 92.11  E-value: 3.90e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15073   5 AYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPiNYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTpCTLT---QERLFV 193
Cdd:cd15073  85 MASIGLLTVVAVDRYLTICRP-DLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGAT-CTINwrkNDSSFV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 VYSSSGS---FFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepepls 270
Cdd:cd15073 163 SYTMSVIvvnFIVPLAVMFYCYYNVSRFVKK------------------------------------------------- 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradKPANGISVHQFIEEKQRISLSKerkaarvLGVIMGV-FVVCWLPFFLMYAIVPFCT-NCAPPSQRVVDFVtwlgYV 348
Cdd:cd15073 194 ----VLASDCLESVNIDWTDQNDVTK-------MSVIMIVmFLVAWSPYSIVCLWASFGEpKKIPPWMAIIPPL----FA 258
                       330       340
                ....*....|....*....|.
gi 12229835 349 NSS--LNPIIYTIYNKDFRTA 367
Cdd:cd15073 259 KSStfYNPCIYVIANKKFRRA 279
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
33-368 5.03e-21

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 91.59  E-value: 5.03e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIIsVFTYRPLRSVQNFFVVSLAVADLTVALFvLPLNVAYRLL-NQWLLGSYLCQMWLTC 111
Cdd:cd14974   1 IVSLVLYALIFLLGLPGNGLVIW-VAGFKMKRTVNTVWFLNLALADFLFCLF-LPFLIVYIAMgHHWPFGSVLCKLNSFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWND---------WPAQFTEDT 182
Cdd:cd14974  79 ISLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTvthhngrscNLTCVEDYD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 183 PCTLTQERLFVVYSSSGsFFIPLIIMSVVYAKIFFATKRRLRERtrklgtlavpappqrtSSRPLaelesvasqedetep 262
Cdd:cd14974 159 LRRSRHKALTVIRFLCG-FLLPLLIIAICYSVIAVKLRRKRLAK----------------SSKPL--------------- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvhqfieekqrislskerkaaRVLGVIMGVFVVCWLPF--FLMYAIVPFCTNcAPPSQRVVD 340
Cdd:cd14974 207 ---------------------------------------RVLLAVVVAFFLCWLPYhvFALLELVAAAGL-PEVVLLGLP 246
                       330       340
                ....*....|....*....|....*...
gi 12229835 341 FVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14974 247 LATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
35-368 7.87e-21

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 91.38  E-value: 7.87e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAII-LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15094   2 ISAVLYGLIcIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECF-LIGLPFLIVTMILKYWPFGAAMCKIYMVLTS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgwndwPAQFTEDTP---CTL---- 186
Cdd:cd15094  81 INQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIIL-----YASTVPDSGrysCTIvwpd 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 ----TQERLFVVYSSSGSFFIPLIIMSVVYAKIFfatkrrlrertRKLGTLAvpapPQRTSSrplaelesvasqedetep 262
Cdd:cd15094 156 ssavNGQKAFTLYTFLLGFAIPLLLISVFYTLVI-----------LRLRTVG----PKNKSK------------------ 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvhqfieEKQRislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVV--- 339
Cdd:cd15094 203 -------------------------EKRR----SHRKVTRLVLTVISVYIICWLPYWAFQVHLIFLPPGTDMPKWEIlmf 253
                       330       340
                ....*....|....*....|....*....
gi 12229835 340 DFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15094 254 LLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
42-368 1.32e-20

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 91.00  E-value: 1.32e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15205  10 IFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWN---------DWPAQFTEDTPCTLTQERLF 192
Cdd:cd15205  90 TMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQlevkydflyEKRHVCCLERWYSPTQQKIY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFFatkrRLRERTRKLGTLAVPAPPQRTSSRplaelesvasqedetepspepeplssr 272
Cdd:cd15205 170 TTFILVILFLLPLTTMLFLYSRIGY----ELWIKKRVGDASVLQTIHGIEMSK--------------------------- 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhqfieekqriSLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFcTNCAPPSQRV-----VDFVTWLGY 347
Cdd:cd15205 219 --------------------ISRKKKRAVKMMVTVVLLFAVCWAPFHVVHMMIEY-SNLENKYDGVtikliFAIVQLIGF 277
                       330       340
                ....*....|....*....|.
gi 12229835 348 VNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15205 278 SNSFNNPIVYAFMNENFKKNF 298
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
33-368 2.16e-20

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 90.27  E-value: 2.16e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15981   1 AMFILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPinYAQKRTIRRVNTMIAAVWALSLVISVP-----------------------PLL 169
Cdd:cd15981  81 GMSVSASVFTLVAIAVERFRCIVHP--FRQKLTLRKAIVTIVIIWVLALIIMCPsavtltvtreehhfmvddynnsyPLY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 170 G-WNDWPAQftedtpctlTQERLFVVYSSSGSFFIPLIIMSVVYAKIFFatkrrlrertrKLGTLAVPAPPQRTSSrpla 248
Cdd:cd15981 159 ScWEAWPDT---------EMRKIYTTVLFSHIYLAPLTLIVIMYARIAF-----------KLFKSSAPIRGSQGEE---- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 249 elesvasqedetepspepeplssradkpangisvhqfiEEKQRISlSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFC 328
Cdd:cd15981 215 --------------------------------------EEGRRVS-KRKIKVINMLIIVALFFTLSWLPLWTLMLLTDYG 255
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 12229835 329 TNCAPP----SQRVVDFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15981 256 HLSEDQlnlvTVYVFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
37-235 3.89e-20

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 88.83  E-value: 3.89e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALF-VLPlNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFnVLP-QLIWDITYRFYGGDLLCRLVKYLQVVG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYaQKRTIRRVNTMIAAVWALSLVISVPPLL---------GWNDWPAQFTEDtpctl 186
Cdd:cd15196  84 MYASSYVLVATAIDRYIAICHPLSS-HRWTSRRVHLMVAIAWVLSLLLSIPQLFifsyqevgsGVYDCWATFEPP----- 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 12229835 187 TQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRlRERTRKLgTLAV 235
Cdd:cd15196 158 WGLRAYITWFTVAVFVVPLIILAFCYGRICYVVWRA-KIKTVKL-TLVV 204
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
40-368 5.56e-20

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 89.18  E-value: 5.56e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15980   8 LLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPinYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpaqftedtpctLTQERLFVVYSSSG 199
Cdd:cd15980  88 VFTLVAIAVDRFRCIVYP--FKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLH-------------VQEEKNYRVVLGSQ 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 200 SFFIPliimsvvyakIFFATKRRLRERTRKLGTLAVPAppqrtsSRPLAELESVAsqedetEPSPEPEPLSSRADKPANG 279
Cdd:cd15980 153 NKTSP----------VYWCREDWPNQEMRKIYTTVLFA------NIYLAPLSLIV------IMYARIGITLFKTAMPHTG 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 280 ISVHQfieekQRISLSKER-KAARVLGVIMGVFVVCWLPFFLMYAIVPFcTNCAPPSQRVVD-----FVTWLGYVNSSLN 353
Cdd:cd15980 211 KHNQE-----QRHVVSRKKqKVIKMLLIVALLFILSWLPLWTLMMLSDY-ANLSPNQLQIINiyiypFAHWLAFFNSSVN 284
                       330
                ....*....|....*
gi 12229835 354 PIIYTIYNKDFRTAF 368
Cdd:cd15980 285 PIIYGFFNENFRRGF 299
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-367 7.10e-20

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 88.70  E-value: 7.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVaYRLLNQ--WLLGSYLCQMWLT 110
Cdd:cd15132   1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLI-LLCLPFDL-YRLWKSrpWIFGEFLCRLYHY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 111 CDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL------GWNDWPAQFTED--- 181
Cdd:cd15132  79 ISEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFlvgveqDNNIHPDDFSREckh 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 182 TPCTLTQERLFV-VYSSSGSFFIPLIIMSVVYAKIFfatkrrlRERTRKLGTLAVPAPPQRTSSrplaelesvasqedet 260
Cdd:cd15132 159 TPYAVSSGLLGImIWVTTTYFFLPMLCLSFLYGFIG-------RKLWKSKNDLRGPNAAARERS---------------- 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 261 epspepeplssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFC--TNCAPPSQRV 338
Cdd:cd15132 216 ------------------------------------HRQTVRILAVVVLAFIICWLPFHIGRILFANTedYRTMMFSQYF 259
                       330       340
                ....*....|....*....|....*....
gi 12229835 339 VDFVTWLGYVNSSLNPIIYTIYNKDFRTA 367
Cdd:cd15132 260 NIVAMQLFYLSASINPILYNLISRKYRAA 288
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
42-368 8.02e-20

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 88.39  E-value: 8.02e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15978  10 IFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVSTF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDT---------PCTLTQERLF 192
Cdd:cd15978  90 NLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNStgnmcrllwPNDVTQQSWY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 vVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd15978 170 -IFLLLILFLIPGIVMMTAYGLISLELYR--------------------------------------------------- 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpanGIsvhQFIEEKQRIslskerkaARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPP--SQRVVDFVTWLGYVNS 350
Cdd:cd15978 198 ------GI---KFLMAKKRV--------IRMLIVIVILFFLCWTPIFSANAWRAFDTRSADRllSGAPISFIHLLSYTSA 260
                       330
                ....*....|....*...
gi 12229835 351 SLNPIIYTIYNKDFRTAF 368
Cdd:cd15978 261 CVNPIIYCFMNKRFRMGF 278
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-362 8.66e-20

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 88.64  E-value: 8.66e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15197   5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRtiRRVNTMIAAVWALSLVISVPPLL-------------GWNDWPAQFtedtp 183
Cdd:cd15197  85 YASTYVLVALSIDRYDAICHPMNFSQSG--RQARVLICVAWILSALFSIPMLIifektglsngevqCWILWPEPW----- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 184 ctltQERLFVVYSSSGSFFIPLIIMSVVYA----KIFFATKRRLRERTRKLGtlavpAPPQRTSSrplaelesvasqede 259
Cdd:cd15197 158 ----YWKVYMTIVAFLVFFIPATIISICYIiivrTIWKKSKIQVTINKAGLH-----DGSSRRSS--------------- 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 260 tepspepeplssradkpangisvHQFIEEKQRIslskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFctNCAPPSQ--- 336
Cdd:cd15197 214 -----------------------SRGIIPRAKI------KTIKMTFVIVTVFIICWSPYFVFDLLDVF--GLLPRSKtki 262
                       330       340
                ....*....|....*....|....*.
gi 12229835 337 RVVDFVTWLGYVNSSLNPIIYTIYNK 362
Cdd:cd15197 263 AAATFIQSLAPLNSAINPLIYCLFST 288
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
36-367 9.70e-20

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 88.40  E-value: 9.70e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVaYRL--LNQWLLGSYLCQMWLTCDI 113
Cdd:cd15131   4 TVTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFL-CMPLDL-YRLwqYRPWNFGDLLCKLFQFVSE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP--PLLGWNDWPAQFTEDT-PCTLTQER 190
Cdd:cd15131  82 SCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPifVLVGVEHENGTNPIDTnECKATEYA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 L------FVVYSSSGSFFIPLIIMSVVYAKIffatKRRLRERTRKlgtLAVPAPPQRTSSrplaelesvasqedetepsp 264
Cdd:cd15131 162 VrsglltIMVWVSSVFFFLPVFCLTVLYSLI----GRKLWRRRRE---NIGPNASHRDKN-------------------- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPP-----SQ--R 337
Cdd:cd15131 215 --------------------------------NRQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSFEAGSLeialiSQycN 262
                       330       340       350
                ....*....|....*....|....*....|
gi 12229835 338 VVDFVtwLGYVNSSLNPIIYTIYNKDFRTA 367
Cdd:cd15131 263 LVSFV--LFYLSAAINPILYNIMSKKYRVA 290
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
41-365 1.13e-19

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 88.26  E-value: 1.13e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd15397   9 LVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTVSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 121 LNLCVIALDRYWAITDPINYaqKRTIRRVNTMIAAVWALSLVISVP----------PLLGWNDWPAQFTEDTPCT----L 186
Cdd:cd15397  89 LSLVLIALERHQLIINPTGW--KPSVSQAYLAVVVIWMLACFISLPflafhiltdePYKNLSHFFAPLADKAVCTeswpS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQERLfvVYSSSGSFF---IPLIIMSVVYAKIFfatkRRLRERTRKLgtlavpappQRTSsrplaelesvasqedeteps 263
Cdd:cd15397 167 EHHKL--AYTTWLLLFqycLPLLFILVCYLRIY----LRLRRRKDML---------ERRG-------------------- 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfiEEKQRISLSKerKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT 343
Cdd:cd15397 212 -----------------------EYNRRAGHSK--RINVMLVSLVAAFALCWLPLNVFNAIADWNHEAIPHCQHNLIFSL 266
                       330       340
                ....*....|....*....|....
gi 12229835 344 --WLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15397 267 chLAAMASTCVNPIIYGFLNSNFK 290
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
41-166 1.23e-19

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 87.95  E-value: 1.23e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd15399   9 SIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVST 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 12229835 121 LNLCVIALDRYWAITdpINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15399  89 VTLTVIALDRHRCIV--YHLESKISKKISFLIIGLTWAASALLASP 132
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
33-368 2.11e-19

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 87.27  E-value: 2.11e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15401   1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPpllgwNDWPAQFTEDT---PCTLTQ- 188
Cdd:cd15401  81 GLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVP-----NFFVGSLQYDPriySCTFAQt 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 -ERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKrRLRERTRKlgtlavpappqrtssrplaelesvasqedetepspepe 267
Cdd:cd15401 156 vSSSYTITVVVVHFIVPLSIVTFCYLRIWVLVI-QVKHRVRQ-------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 268 plssradkpangisvhqfiEEKQRISLSKERKAARVLgVIMGVFVVCWLPF-FLMYAIVPFCTNCAPPSQRVVdFVT--W 344
Cdd:cd15401 197 -------------------DSKQKLKANDIRNFLTMF-VVFVLFAVCWGPLnFIGLAVAINPLKVAPKIPEWL-FVLsyF 255
                       330       340
                ....*....|....*....|....
gi 12229835 345 LGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15401 256 MAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
36-368 2.85e-19

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 86.93  E-value: 2.85e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15091   4 TAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWPFGDVLCKIVISIDYYN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLT-QERLFVV 194
Cdd:cd15091  83 MFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQfPDDDYSW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 195 YSSSG-------SFFIPLIIMSVVYAKIFFATKR-RLRERTRklgtlavpappqrtssrplaelesvasqedetepspep 266
Cdd:cd15091 163 WDTFMkicvfifAFVIPVLIIIVCYTLMILRLKSvRLLSGSR-------------------------------------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangisvhqfieEKQRislsKERKAARVLGVIMGVFVVCWLP---FFLMYAIVPFCTNCAPPSQRVvdFVT 343
Cdd:cd15091 205 ---------------------EKDR----NLRRITRLVLVVVAVFVVCWTPihiFILVEALGSVSHSTAAVSSYY--FCI 257
                       330       340
                ....*....|....*....|....*
gi 12229835 344 WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15091 258 ALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
33-368 2.97e-19

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 86.84  E-value: 2.97e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADlTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15092   1 VTIVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALAD-TLVLLTLPFQGTDIFLGFWPFGNALCKTVIAID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpAQFTEDTPCTLTQ---- 188
Cdd:cd15092  80 YYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGS---AQVEDEEIECLVEiptp 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ----ERLFVVYSSSGSFFIPLIIMSVVYAKIFfatkRRLRertrklgtlavpappqrtssrplaelesvasqedetepsp 264
Cdd:cd15092 157 qdywDPVFGICVFLFSFIIPVLIISVCYSLMI----RRLR---------------------------------------- 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpanGISVHQFIEEKQRislsKERKAARVLGVIMGVFVVCWLPFFLMyaIVPFCTNCAPPSQRVV---DF 341
Cdd:cd15092 193 --------------GVRLLSGSKEKDR----NLRRITRLVLVVVAVFVGCWTPIQIF--VLAQGLGVQPSSETAVailRF 252
                       330       340
                ....*....|....*....|....*..
gi 12229835 342 VTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15092 253 CTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
41-365 3.31e-19

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 86.72  E-value: 3.31e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQ-WLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15394   9 LVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRgWVFGRFMCYFVFLMQPVTVYVS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINyaQKRTIRRVNTMIAAVWALSLVISVPPLLgwNDWPAQFTED--TPCT---LTQERLFVV 194
Cdd:cd15394  89 VFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLALPAAA--HTYYVEFKGLdfSICEefwFGQEKQRLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 195 YSSSG---SFFIPLIIMSVVYAKIFFATKRRlrertrklgtlAVPAppqrtssrplaelesvasqedetepspepeplss 271
Cdd:cd15394 165 YACSTlliTYVLPLLAISLSYLRISVKLRNR-----------VVPG---------------------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpangiSVHQFIEEKQRislSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAppSQRVVDFVT----WLGY 347
Cdd:cd15394 200 ---------SMTQSQAEWDR---ARRRKTFRLLVVVVVAFAICWLPLHIFNVIRDIDIDLI--DKQYFNLIQllchWLAM 265
                       330
                ....*....|....*...
gi 12229835 348 VNSSLNPIIYTIYNKDFR 365
Cdd:cd15394 266 SSACYNPFLYAWLHDSFR 283
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
40-216 4.41e-19

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 85.76  E-value: 4.41e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTI---VGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15214   4 IAIIIIAIlicLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLIS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWP-AQFTEDTPCTLTQERLFVVY 195
Cdd:cd15214  84 SASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEfDRFKWMCVAAWHKEAGYTAF 163
                       170       180
                ....*....|....*....|.
gi 12229835 196 SSSGSFFIPLIIMSVVYAKIF 216
Cdd:cd15214 164 WQVWCALLPFVVMLVCYGFIF 184
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
38-368 4.49e-19

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 86.53  E-value: 4.49e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIIsVFTYRPLRSVQNFFVVSLAVAD---LTVALFVLPLNVAYRLLNQWLLGSYLCQMWL--TCD 112
Cdd:cd14978   6 VLPVICIFGIIGNILNLV-VLTRKSMRSSTNVYLAALAVSDilvLLSALPLFLLPYIADYSSSFLSYFYAYFLPYiyPLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL------GWNDWPAQFTEDTPCTL 186
Cdd:cd14978  85 NTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFeyevveCENCNNNSYYYVIPTLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQERLFVVY-----SSSGSFFIPLIIMSVVYAKIFFAtkrrLRERTRKLGTLAVpappqrtssrplaelesvasqedete 261
Cdd:cd14978 165 RQNETYLLKyyfwlYAIFVVLLPFILLLILNILLIRA----LRKSKKRRRLLRR-------------------------- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 262 pspepeplssradkpangisvhqfIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPS--QRVV 339
Cdd:cd14978 215 ------------------------RRRLLSRSQRRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPiyQLLG 270
                       330       340
                ....*....|....*....|....*....
gi 12229835 340 DFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14978 271 DISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
33-368 7.73e-19

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 85.43  E-value: 7.73e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADlTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15090   1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGNILCKIVISID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDtpCTLT----- 187
Cdd:cd15090  80 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSID--CTLTfshps 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 --QERLFVVYSSSGSFFIPLIIMSVVYAKIFFatkrrlrertrklgtlavpappqrtssrplaELESVASQEDEtepspe 265
Cdd:cd15090 158 wyWENLLKICVFIFAFIMPVLIITVCYGLMIL-------------------------------RLKSVRMLSGS------ 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 266 peplssradkpangisvhqfiEEKQRislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTncAPPSqrVVDFVTW- 344
Cdd:cd15090 201 ---------------------KEKDR----NLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT--IPET--TFQTVSWh 251
                       330       340
                ....*....|....*....|....*...
gi 12229835 345 ----LGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15090 252 fciaLGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
38-221 8.47e-19

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 84.90  E-value: 8.47e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNsLVIISVFTYRP-LRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15215   5 LIVIFLCASLFGN-IVLLLVFQRKPqLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDwpAQFTE-DTPCTL--TQERLFV 193
Cdd:cd15215  84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQ--AAFDErNALCSViwGSSYSYT 161
                       170       180
                ....*....|....*....|....*...
gi 12229835 194 VYSSSGSFFIPLIIMSVVYAKIFFATKR 221
Cdd:cd15215 162 ILSVVSSFVLPVIIMLACYSMVFRAARR 189
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-368 8.85e-19

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 85.67  E-value: 8.85e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd16004   8 SLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRTIRRVntMIAAVWALSLVISVPPLLGWN------------DWPAQFTEDTPCTLT 187
Cdd:cd16004  88 IYSMTAIAADRYMAIIHPFKPRLSAGSTKV--VIAGIWLVALALAFPQCFYSTvtmdqgrtkcivAWPGDSGGKHQLTYH 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 QERLFVVYsssgsfFIPLIIMSVVYAKIffatkrrlrerTRKLGTLAVPAPPQRtssrplaelesvasqedetepspepe 267
Cdd:cd16004 166 LAVIVLIY------LLPLAVMFVTYSII-----------GITLWRSAVPGHQAH-------------------------- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 268 plssradkpangisvhqfieEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTN--CAPPSQRVVDFVTWL 345
Cdd:cd16004 203 --------------------GAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILGSFNEDiyCQKYIQQVYLAIFWL 262
                       330       340
                ....*....|....*....|...
gi 12229835 346 GYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd16004 263 AMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
42-368 8.93e-19

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 85.30  E-value: 8.93e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd16002  10 IVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASIY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVntMIAAVWALSLVISVP--------PLLG----WNDWPAQFTEDtpctltQE 189
Cdd:cd16002  90 SMTAIALDRYMAIIHPLQPRLSATATKV--VICVIWVLAFLLAFPqgyysdteEMPGrvvcYVEWPEHEERK------YE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIFFatkrrlrertrklgTLAVPAPPQRTSSRplaelesvaSQEdetepspepepl 269
Cdd:cd16002 162 TVYHVCVTVLIYFLPLLVIGCAYTVVGI--------------TLWASEIPGDSSDR---------YHE------------ 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfieekqriSLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPS--QRVVDFVTWLGY 347
Cdd:cd16002 207 -----------------------QVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQYFHPELYEQKfiQQVYLAIMWLAM 263
                       330       340
                ....*....|....*....|.
gi 12229835 348 VNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd16002 264 SSTMYNPIIYCCLNDRFRVGF 284
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
42-368 9.12e-19

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 85.29  E-value: 9.12e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVlPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15973  10 VCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSV-PFLAASAALQHWPFGSAMCRTVLSVDGINMFTSVF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgWNDWPAQFTEDTPCTL-----TQERLFVVYS 196
Cdd:cd15973  89 CLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIII-FADTATRKGQAVACNLiwphpAWSAAFVIYT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 197 SSGSFFIPLIIMSVVYAKIFFatkrRLRERTRKLGTlavpapPQRTSSrplaelesvasqedetepspepeplssradkp 276
Cdd:cd15973 168 FLLGFLLPVLAIGLCYILIIG----KMRAVALKAGW------QQRRKS-------------------------------- 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 277 angisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCappSQRVVDFVTWLGYVNSSLNPII 356
Cdd:cd15973 206 --------------------EKKITRMVLMVVTVFVICWMPFYVVQLLNLFLPRL---DATVNHASLILSYANSCANPIL 262
                       330
                ....*....|..
gi 12229835 357 YTIYNKDFRTAF 368
Cdd:cd15973 263 YGFLSDNFRRSF 274
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
34-230 1.01e-18

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 85.11  E-value: 1.01e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVAlFVLPLNVAYRlLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15182   2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFT-FTLPFWASYH-SSGWIFGEILCKAVTSIFY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQfTEDTPCTLT--QERL 191
Cdd:cd15182  80 IGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSD-EDGSLCEYSsiKWKL 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 12229835 192 FVVYSSSGSFFIPLIIMSVVYAKI---FFATKRRLRERTRKL 230
Cdd:cd15182 159 GYYYQQNLFFLIPLGIIVYCYVRIlqtLMRTRTMRKHRTVKL 200
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
37-365 1.05e-18

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 85.41  E-value: 1.05e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQwllgsylcQMWLTCDILCC 116
Cdd:cd15204   5 VVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQ--------RSWTHGDVLCA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILN----------LCVIALDRYWAITDPINYAQKRtiRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPC-- 184
Cdd:cd15204  77 VVNYLRtvslyvstnaLLVIAIDRYLVIVHPLKPRMKR--RTACVVIALVWVVSLLLAIPSAVYSKTTPYANQGKIFCgq 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 185 --TLTQERLFVVYSSS---GSFFIPLIIMSVVYAKIFfatkRRLRERTrklgtlavpAPPQRTssrplaelesvasqede 259
Cdd:cd15204 155 iwPVDQQAYYKAYYLFlfvLEFVLPVLIMTLCYLRIV----RKVWFRR---------VPGQQT----------------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 260 tepspepeplssradkpangisvhqfieEKQRISLSKERKAARVLGVIMGVFVVCWLPFFlMYAIV----PFCTNCAPPS 335
Cdd:cd15204 205 ----------------------------EQIRRRLRRRRRKVRLLVVILTAFVLCWAPYY-GYAIVrdffPTLLSKEKLN 255
                       330       340       350
                ....*....|....*....|....*....|
gi 12229835 336 QRVVDFVTWLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15204 256 TTIFYIVEALAMSNSMINTVVYVAFNNNIR 285
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
33-368 1.14e-18

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 85.12  E-value: 1.14e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAYR-LLNQWLLGSYLCQMWLTC 111
Cdd:cd14985   1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVF-VLTLPLWATYTaNQYDWPFGAFLCKVSSYV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTL--TQE 189
Cdd:cd14985  80 ISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKTACIMlyPHE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSG---SFFIPLIIMSVVYAKIffatKRRLRERtrklgtlavpappqrtssrplaelesvasqedetepspep 266
Cdd:cd14985 160 AWHFGLSLELnilGFVLPLLIILTCYFHI----ARSLRKR---------------------------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangisvhqfiEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTW-- 344
Cdd:cd14985 196 --------------------YERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLGAIRPCFWELFLDLgl 255
                       330       340
                ....*....|....*....|....*....
gi 12229835 345 -----LGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14985 256 piatcLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
34-365 2.52e-18

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 84.06  E-value: 2.52e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15209   2 ALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL-LGWNDW-PAQFTedtpCTLTQ--E 189
Cdd:cd15209  82 LSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFfIGSLQYdPRIYS----CTFAQtvS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIF---FATKRRLRertrklgtlavpaPPQRTSSRPlaelesvasqedetepspep 266
Cdd:cd15209 158 TVYTITVVVIHFLLPLLIVSFCYLRIWvlvLQVRQRVK-------------PDQRPKLKP-------------------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssrADkpangisVHQFIeekqrislskerkaarVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT--W 344
Cdd:cd15209 205 ------AD-------VRNFL----------------TMFVVFVLFAVCWAPLNFIGLAVAINPKEMAPKIPEWLFVAsyF 255
                       330       340
                ....*....|....*....|.
gi 12229835 345 LGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15209 256 MAYFNSCLNAIIYGLLNQNFR 276
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
36-368 3.92e-18

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 84.43  E-value: 3.92e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNV-AYRLLNQWLLGSYLCQMWLTCDIL 114
Cdd:cd15005   4 LTTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMaSVRHGSGWIYGALSCKVIAFLAVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWpAQFTEDTPCTLtQERLFVV 194
Cdd:cd15005  84 FCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTY-TFIREEDQCTF-EHRSYKA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 195 YSSSGSFFIPLIIMS---VVYAKIFFATKRRLRERTRKLgtlaVPAPPQR-TSSRPLAELESVASQEDETEPSPEPEPLS 270
Cdd:cd15005 162 NDTLGFMLVLAVVIAathLVYLKLLIFLRHHRKMKPAQL----VPAISQNwTFHGPGATGQAAANWTAGFGRGPTPPTLL 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 SRADKPANGIS-VHQFIEEKqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPsQRVVDFVTWLGYVN 349
Cdd:cd15005 238 GIRQAFHSGARrLLVLDEFK------MEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRGYAVP-QGFLTAAVWMTFAQ 310
                       330
                ....*....|....*....
gi 12229835 350 SSLNPIIYTIYNKDFRTAF 368
Cdd:cd15005 311 AGVNPIVCFFFNRELRKCL 329
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
34-368 5.55e-18

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 83.24  E-value: 5.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd14977   2 VIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWN---DWPAQFTEDTPCTLTQER 190
Cdd:cd14977  82 TSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTvarESSLDNSSLTVCIMKPST 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 -------------LFVVYsssgsFFIPLIIMSVVYAKIffatkrrlrerTRKLGtlavpappqrtssrplaelesvasqe 257
Cdd:cd14977 162 pfaetypkarswwLFGCY-----FCLPLAFTAVCYLLM-----------ARTLI-------------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 258 detepspepeplssradKPANGISVHQFIEEKQRislskeRKAARVLGVIMGVFVVCWLPFFL--MYAIVPFCTNCAPPS 335
Cdd:cd14977 200 -----------------RAAKEYTRGTKKHMKQR------RQLAKTVLCLVLVFAFCWLPEHIsnILRATLYNEVLIDTR 256
                       330       340       350
                ....*....|....*....|....*....|....*.
gi 12229835 336 Q--RVVDFVT-WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14977 257 StlDILDLIGqFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
41-368 9.06e-18

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 82.76  E-value: 9.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVT-IVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVaYRLLNQ--WLLGSYLCQMWLTCDILCCT 117
Cdd:cd15134   8 GIIFVTgVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFEL-YTIWQQypWVFGEVFCKLRAFLSEMSSY 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP-------PLLGWNDWPAQFTEDTP-CTLTQE 189
Cdd:cd15134  87 ASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPfaiqtriVYLEYPPTSGEALEESAfCAMLNE 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGS----FFIPLIIMSVVYAKIFFATKRRLRERtrklgtlavpaPPQRTSSRplaelesvasqedetepspe 265
Cdd:cd15134 167 IPPITPVFQLStflfFIIPMIAIIVLYVLIGLQLRRSTLLR-----------RGQRSVSG-------------------- 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 266 peplssradkpangisvhqfieekQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTW- 344
Cdd:cd15134 216 ------------------------GRRSSQSRRTVLRMLVAVVVAFFICWAPFHAQRLLTVYAKNMTPPYLFINRILFYi 271
                       330       340
                ....*....|....*....|....*..
gi 12229835 345 ---LGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15134 272 sgvLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
34-368 1.21e-17

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 82.26  E-value: 1.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15402   2 ALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL-LGWNDWPAQFTEdtpCTLTQ--ER 190
Cdd:cd15402  82 LSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLfVGSLQYDPRIYS---CTFAQsvSS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 LFVVYSSSGSFFIPLIIMSVVYAKIFFATKrRLRERTRklgtlavpaPPQRTSSRPlaelesvasqedetepspepepls 270
Cdd:cd15402 159 AYTIAVVFFHFILPIIIVTFCYLRIWILVI-QVRRRVK---------PDNKPKLKP------------------------ 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpangisvHQFieekqrislskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT--WLGYV 348
Cdd:cd15402 205 ------------HDF-------------RNFVTMFVVFVLFAVCWAPLNFIGLAVAVDPETIVPRIPEWLFVAsyYMAYF 259
                       330       340
                ....*....|....*....|
gi 12229835 349 NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15402 260 NSCLNAIIYGLLNQNFRREY 279
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-365 1.49e-17

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 81.72  E-value: 1.49e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd14999   4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADL-LYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINyAQKRTIRRVNTMIAAVWALSLVISVPPLL------GWNDWPAQFTEDTPC-TLTQE 189
Cdd:cd14999  83 HASIFTLTVMSTERYLAVVKPLD-TVKRSKSYRKLLAGVIWLLSLLLTLPMAImirlvtVEDKSGGSKRICLPTwSEESY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIffATKRRLrertrklgtlavpapPQRTSSRplaelesvasqedetepspepepl 269
Cdd:cd14999 162 KVYLTLLFSTSIVIPGLVIGYLYIRL--ARKYWL---------------SQAAASN------------------------ 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfieeKQRISLSKERKAARVLGVIMgVFVVCWLPF---FLMYAIVPFcTNCAPPSQRVVDF-VTWL 345
Cdd:cd14999 201 -------------------SSRKRLPKQKVLKMIFTIVL-VFWACFLPFwiwQLLYLYSPS-LSLSPRTTTYVNYlLTCL 259
                       330       340
                ....*....|....*....|
gi 12229835 346 GYVNSSLNPIIYTIYNKDFR 365
Cdd:cd14999 260 TYSNSCINPFLYTLLTKNYK 279
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
38-368 1.67e-17

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 81.38  E-value: 1.67e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLL---GSYLCQMWLTCDIL 114
Cdd:cd15103   6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLvprDSFEQHIDNVIDSM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTS---SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVppllgwndwpaqftedtpctltqerL 191
Cdd:cd15103  86 ICSSllaSICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGI-------------------------L 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGS--------FFIPLIIMSVVYAKIFFatkrRLRERTRKLGTLAVPAPPQrtssrplaelesvasqedeteps 263
Cdd:cd15103 141 FIIYSDSVPviiclismFFAMLVLMASLYVHMFL----LARSHVKKIAALPGQRSTR----------------------- 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfieekQRISLskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT 343
Cdd:cd15103 194 --------------------------QRANM----KGAVTLTILLGVFIFCWAPFFLHLTLMISCPSNPYCACYMSHFNV 243
                       330       340
                ....*....|....*....|....*..
gi 12229835 344 WLGYV--NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15103 244 YLILImcNSVIDPLIYAFRSQELRKTF 270
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-368 1.70e-17

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 82.19  E-value: 1.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVaYRLLNQW--LLGSYLCQMWLTCDI 113
Cdd:cd15133   4 CLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLEL-YELWQNYpfLLGSGGCYFKTFLFE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP--PLLGWNDWPAQFTEDTPCTLTQERL 191
Cdd:cd15133  83 TVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPntSLHGIKFLGSGVPASAQCTVRKPQA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 ---FVVYSSSGSFFI-PLIIMSVVYakiFFATKRRLRERtrklgtlavpappqrtssrplaelesvasqedetepspepe 267
Cdd:cd15133 163 iynMIPQHTGHLFFVlPMAVISVLY---LLMALRLARER----------------------------------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 268 PLSSRADKPANGISVHQFIEEKQRislskERKAARVLGVIMGVFVVCWLPFF---LMYAIVPFCTNCAPPSQRVVDFVT- 343
Cdd:cd15133 199 GLDATGAGSKIGTRTGQLLQHPRT-----RAQVTKMLFILVVVFAICWAPFHidrLMWSFISDWTDNLHEVFQYVHIISg 273
                       330       340
                ....*....|....*....|....*
gi 12229835 344 WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15133 274 VFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
33-368 1.72e-17

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 81.92  E-value: 1.72e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADlTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFGELLCKAVLSID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL-LGWNDWPAQFTedTPCTLTQERL 191
Cdd:cd15089  80 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMvMAVTKTPRDGA--VVCMLQFPSP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSG-------SFFIPLIIMSVVYAKIFfatkrrLRERTRKLGTLAvpappqrtssrplaelesvasqedetepsp 264
Cdd:cd15089 158 SWYWDTVTkicvfifAFVVPILVITVCYGLMI------LRLRSVRLLSGS------------------------------ 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpangisvhqfiEEKQRislsKERKAARVLGVIMGVFVVCWLPFFLmYAIVPFCTNCAPPSQRVV---DF 341
Cdd:cd15089 202 ----------------------KEKDR----NLRRITRMVLVVVAAFIICWTPIHI-FVIVWTLVDIDRRNPLVVaalHL 254
                       330       340
                ....*....|....*....|....*..
gi 12229835 342 VTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15089 255 CIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
34-368 2.09e-17

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 81.44  E-value: 2.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15400   2 ALSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPpllgwNDWPAQFTEDT---PCTLTQ-- 188
Cdd:cd15400  82 LSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVP-----NFFVGSLEYDPriySCTFVQta 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKrRLRERTRKlgtlavpappqrtssrplaelesvasqedetepspepep 268
Cdd:cd15400 157 SSSYTIAVVVIHFIVPITVVSFCYLRIWVLVI-QVRRKVKS--------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lssradkpangisvhqfiEEKQRISLSKERKAARVLgVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT--WLG 346
Cdd:cd15400 197 ------------------ESKPRLKPSDFRNFLTMF-VVFVIFAICWAPLNLIGLAVAINPQEMAPKVPEWLFVVsyFMA 257
                       330       340
                ....*....|....*....|..
gi 12229835 347 YVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15400 258 YFNSCLNAIIYGLLNQNFRKEY 279
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
42-368 2.44e-17

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 81.13  E-value: 2.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd16003  10 VVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFASIY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVntMIAAVWALSLVISVPP------------LLGWNDWPAQFTEdtpcTLTQE 189
Cdd:cd16003  90 SMTAIAVDRYMAIIDPLKPRLSATATKV--VIGSIWILAFLLAFPQclysktkvmpgrTLCFVAWPGGPDQ----HFTYH 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYsssgSFFIPLIIMSVVYAKIFFatkrrlrertrklgTLAVPAPPQRTSsrplaelesvasqedetepspepepl 269
Cdd:cd16003 164 IIVIVL----VYCLPLLVMGITYTIVGI--------------TLWGGEIPGDTS-------------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfieEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPS--QRVVDFVTWLGY 347
Cdd:cd16003 200 ------------------DKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIVTGLYQQLNRWKyiQQVYLASFWLAM 261
                       330       340
                ....*....|....*....|.
gi 12229835 348 VNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd16003 262 SSTMYNPIIYCCLNKRFRAGF 282
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
40-368 3.00e-17

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 81.35  E-value: 3.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVaYRLLNQW--LLGSYLCQMWLTCDILCCT 117
Cdd:cd15358   8 LLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLEL-YEMWSNYpfLLGAGGCYFKTLLFETVCF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP--PLLGWNDWP---AQFTEDTP-CTLTQER- 190
Cdd:cd15358  87 ASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPntSLHGIFQLTvpcRGPVPDSAtCMLVKPRw 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 ---LFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRlrertrklgtlavpappqrtssRPLAELESVASQedetepspepe 267
Cdd:cd15358 167 mynLIIQITTLLFFFLPMGTISVLYLLIGLQLKRE----------------------KMLLVLEAKGSK----------- 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 268 plssradkpANGISVHQFIEEKQRislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLG- 346
Cdd:cd15358 214 ---------AGDSYQHRRIQQEKR----RRRQVTKMLFVLVVVFGICWAPFHTDRLMWSFISQWTGELHLAFQYVHIISg 280
                       330       340
                ....*....|....*....|....*
gi 12229835 347 ---YVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15358 281 vffYLSSAANPVLYNLMSTRFREMF 305
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-368 7.53e-17

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 79.99  E-value: 7.53e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15125   5 SLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL------GWNDWPAQFTEDTPCTLTQER 190
Cdd:cd15125  85 GVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVfsevahIMPDDNTTFTACIPYPQTDEM 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 --------LFVVYsssgsFFIPLIIMSVVYAKIffatkrrlrerTRKLGTLAVPAPPQrtssrplaelesvasqedetep 262
Cdd:cd15125 165 hpkihsvlIFLVY-----FLIPLAIISIYYYHI-----------AKTLIKSAHNIPGE---------------------- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvhqfIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPS--QRVVD 340
Cdd:cd15125 207 -----------------------YSEHSKRQMETRKRLAKIVLVFVGLFAFCWFPNHVLYMYRSFNYNEIDSSlgHMIVT 263
                       330       340
                ....*....|....*....|....*....
gi 12229835 341 FVTW-LGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15125 264 LVARvLSFCNSCVNPFALYLLSESFRRHF 292
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
35-358 7.61e-17

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 79.78  E-value: 7.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLLNQWL-LGSYLCQMWLTCDI 113
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDL-LASLVVLVLFFLLGLTEASsRPQALCYLIYLLWY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQF--TEDTPCTLTQERL 191
Cdd:cd14964  80 GANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNtlTGSCYLICTTIYL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYsSSGSFFIPLIIMSVVYAKIFFATKRRLRertrklgtlavpAPPQRTSSRPLAELesvasqedetepspepeplss 271
Cdd:cd14964 160 TWGF-LLVSFLLPLVAFLVIFSRIVLRLRRRVR------------AIRSAASLNTDKNL--------------------- 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpangisvhqfieekqrislskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRvVDFVTWLGYVNSS 351
Cdd:cd14964 206 ---------------------------KATKSLLILVITFLLCWLPFSIVFILHALVAAGQGLNLL-SILANLLAVLAST 257

                ....*..
gi 12229835 352 LNPIIYT 358
Cdd:cd14964 258 LNPFIYC 264
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
33-367 8.37e-17

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 79.89  E-value: 8.37e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15403   1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAItdpINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWN--DWPAQFTEdtpCTL---- 186
Cdd:cd15403  81 WFFVLEGVAILLIISVDRFLII---VQRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTlvEVPARAPQ---CVLgyte 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 -TQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKR---RLRERTRKLGTLAVPAPPQRTSSRPlaelesvasqedetep 262
Cdd:cd15403 155 sPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRnavRIHNHADSLCLSQVSKLGLMGLQRP---------------- 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvHQFieekqRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTN--CAPPSQRVVD 340
Cdd:cd15403 219 --------------------HQM-----NVDMSFKTRAFTTILILFVGFSLCWLPHTVFSLLSVFSRRfyYSSSFYPIST 273
                       330       340
                ....*....|....*....|....*..
gi 12229835 341 FVTWLGYVNSSLNPIIYTIYNKDFRTA 367
Cdd:cd15403 274 CVLWLSYLKSVFNPVIYCWRIKKFREA 300
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
38-368 9.88e-17

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 79.47  E-value: 9.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAII-LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15979   5 LLYSVIfLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTP---CTLTQ----- 188
Cdd:cd15979  85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRghqCRHAWpsaqv 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ERLFVVYSSSGSFFIPLIIMSVVYAKIffatkrrlrERTRKLGTLAvpappqrtssrplaelesvasqedetepspepep 268
Cdd:cd15979 165 RQAWYVLLLLILFFIPGVVMIVAYGLI---------SRELYRGLLA---------------------------------- 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFctncAPPSQR------VVDFV 342
Cdd:cd15979 202 ----------------------------KKRVIRMLVVIVAMFFLCWLPIFSANTWRAF----DPLSAHralsgaPISFI 249
                       330       340
                ....*....|....*....|....*.
gi 12229835 343 TWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15979 250 HLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
42-215 1.70e-16

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 79.01  E-value: 1.70e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd15192  10 IFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCF-LITLPLWAAYTAMEyHWPFGNFLCKIASALVSFNLYASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 121 LNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTL----TQERLFVVYS 196
Cdd:cd15192  89 FLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENTNITVCAFhypsQNSTLLVGLG 168
                       170       180
                ....*....|....*....|..
gi 12229835 197 SSGS---FFIPLIIMSVVYAKI 215
Cdd:cd15192 169 LMKNllgFLIPFLIILTCYTLI 190
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
42-365 1.94e-16

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 78.92  E-value: 1.94e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15389  10 IIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINyaQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQ------ERLFVVY 195
Cdd:cd15389  90 TLTAIALDRHRVILHPLK--PRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCLpsfpepSDLFWKY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 196 SSSGSF----FIPLIIMSVVYAKIffatKRRLRERTrklgtlavpappqrtssrplaelesvasqedetepspepeplss 271
Cdd:cd15389 168 LDLATFilqyVLPLLIIGVAYTRV----AKKLWLRN-------------------------------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpangiSVHQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLmYAIV----PFCTNCAppsqrVVDFVTWLGY 347
Cdd:cd15389 200 ---------AIGDVTTEQYVAQRRKKKKTIKMLMLVVLLFAICWLPLNC-YHVLlsshPIRSNSA-----LFFAFHWLAM 264
                       330
                ....*....|....*...
gi 12229835 348 VNSSLNPIIYTIYNKDFR 365
Cdd:cd15389 265 SSTCYNPFIYCWLNDSFR 282
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
42-368 2.05e-16

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 78.81  E-value: 2.05e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15123  10 IISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWN-------DWPAQFTEDTPCTLTQERL--- 191
Cdd:cd15123  90 TLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDlysfrdpEKNTTFEACAPYPVSEKILqei 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 -----FVVYsssgsFFIPLIIMSVVYAKIffatkrrlrERTRKLGTLAVPAPPQRtssrplaelesvasqedetepspep 266
Cdd:cd15123 170 hsllcFLVF-----YIIPLSIISVYYFLI---------ARTLYKSTFNMPAEEHS------------------------- 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangiSVHQFIEEKQRIslskerkaARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQR----VVDFV 342
Cdd:cd15123 211 --------------HARKQIESRKRV--------AKTVLVLVALFAFCWLPNHILYLYRSFTYHTSVDSSAfhliATIFS 268
                       330       340
                ....*....|....*....|....*.
gi 12229835 343 TWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15123 269 RVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
40-365 3.02e-16

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 78.25  E-value: 3.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAYRLLNqWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15181   8 SLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLL-LLTFPFSVVESIAG-WVFGTFLCKLVGAIHKLNFYCS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLFV------ 193
Cdd:cd15181  86 SLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNANRTSCSFHQYGIHEsnwwlt 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 ---VYSSSGsFFIPLIIMSVVYAKIFfatkRRLRERTRKLgtlavpappqrtssrplaelesvasqedetepspepepls 270
Cdd:cd15181 166 srfLYHVVG-FFLPLLIMGYCYATIV----VTLCQSSRRL---------------------------------------- 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpangisvhqfieEKQrislskerKAARVLGVIMGVFVVCWLPF----FLMYAIV--PFCTNCAPPS--QRVVDFV 342
Cdd:cd15181 201 -----------------QKQ--------KAIRVAILVTLVFCLCWLPYniviFLDTLDDlkAVVKNCKLNDllDAAITVT 255
                       330       340
                ....*....|....*....|...
gi 12229835 343 TWLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15181 256 ESLGFSHCCLNPILYAFIGVKFR 278
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
33-368 4.84e-16

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 77.31  E-value: 4.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYrLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFAL-TLPFWAVS-VVKGWIFGTFMCKLVSLLQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPinyAQKRTIRR--VNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPC------ 184
Cdd:cd15178  79 EANFYSGILLLACISVDRYLAIVHA---TRALTQKRhlVKFVCAGVWLLSLLLSLPALLNRDAFKPPNSGRTVCyenlgn 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 185 -TLTQERLFV-VYSSSGSFFIPLIIMSVVYAkifFATKRRLRERTRklgtlavpappqrtssrplaelesvasqedetep 262
Cdd:cd15178 156 eSADKWRVVLrILRHTLGFLLPLVVMLFCYG---FTIKTLLQTRSF---------------------------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvhqfieEKQRislskerkAARVLGVIMGVFVVCWLPF-------FLMYA-IVPFCTNCAPP 334
Cdd:cd15178 199 -------------------------QKHR--------AMRVIFAVVLAFLLCWLPYnvtvlidTLMRTkLITETCELRNH 245
                       330       340       350
                ....*....|....*....|....*....|....
gi 12229835 335 SQRVVDFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15178 246 VDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
42-368 6.09e-16

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 77.59  E-value: 6.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVaYRLLNQW--LLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15357  10 IFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEV-YEMWSNYpfLFGPVGCYFKTALFETVCFAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPP------LLGWNDWPAQFTEDTPCTLTQERL-- 191
Cdd:cd15357  89 ILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNtsihgiKLQYFPNGTLIPDSATCTVVKPLWiy 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 -FVVYSSSGSFFI-PLIIMSVVYakifFATKRRLRErtrklgtlavpappqrtssrplaelesvasqedetepspepepl 269
Cdd:cd15357 169 nLIIQITSLLFYVlPMGVISVLY----YLMGLKLRG-------------------------------------------- 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssraDKPANGISVHQFIEEKQRISLSKerkaarVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLG--- 346
Cdd:cd15357 201 ----DKSLEADEMNVNIQRPSRKSVTK------MLFVLVLVFAICWAPFHVDRLFFSFVVEWTEPLANVFNLIHVVSgvf 270
                       330       340
                ....*....|....*....|...
gi 12229835 347 -YVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15357 271 fYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
33-368 8.46e-16

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 76.79  E-value: 8.46e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPL-RSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTC 111
Cdd:cd15097   1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL--LGWNDWPAQFTEDTPCTLTQE 189
Cdd:cd15097  81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLsyYDLIDYANSTVCMPGWEEARR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAkiffatkrrlreRTRKLGTLAVpappqrtssRPLAELESvasqedetepspepepl 269
Cdd:cd15097 161 KAMDTCTFAFGYLIPVLVVSLSYT------------RTIKYLWTAV---------DPLEAMSE----------------- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfieekqriSLSKERKAARVLGVIMGVFVVCWLPF---FLMYAIVPFCTNCAPPSQRVVDFVtwLG 346
Cdd:cd15097 203 -----------------------SKRAKRKVTKMIIIVTALFCLCWLPHhvvILCYLYGDFPFNQATYAFRLLSHC--MA 257
                       330       340
                ....*....|....*....|..
gi 12229835 347 YVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15097 258 YANSCLNPIVYALVSKHFRKGF 279
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
35-365 9.84e-16

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 76.34  E-value: 9.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAIILVTIVGNSLVIISVFTYRPLRSVqnFFVVSLAVADLTVALFVLPLNV--AYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15220   2 GLFCMVLLDLTALVGNTAVMVVIAKTPHLRKF--AFVCHLCVVDLLAALLLMPLGIlsSSPFFLGVVFGEAECRVYIFLS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQ---- 188
Cdd:cd15220  80 VCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIAARHCSLHwshs 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 --ERLFVVYSSSGSFFIPLIIMSVVYAKIFfatkrrlrertRKLGTlavpappqrtssrplaelesvasqedetepspep 266
Cdd:cd15220 160 ghRGVFVVLFALVCFLLPLLLILVVYCGVF-----------KVFGG---------------------------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangisvhqfieekqrislskeRKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQrVVDFVTWLG 346
Cdd:cd15220 195 -------------------------------GKAALTLAAIVGQFLCCWLPYFAFHLYSALAASPVSGGE-AEEVVTWLA 242
                       330
                ....*....|....*....
gi 12229835 347 YVNSSLNPIIYTIYNKDFR 365
Cdd:cd15220 243 YSCFAVNPFFYGLLNRQIR 261
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
33-368 1.19e-15

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 76.27  E-value: 1.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLL--NQWLLGSYLCQMWLT 110
Cdd:cd14995   1 VVATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLgpDSWIYGYAGCLLITY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 111 CDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP--PLLGWNDWPAQFTEDTPCTLTQ 188
Cdd:cd14995  81 LQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPwlFLLDLSIKHYGDDIVVRCGYKV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 ERLF--VVYSSSGSFF--IPLIIMSVVYAKIffatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepsp 264
Cdd:cd14995 161 SRHYylPIYLADFVLFyvIPLLLAIVLYGLI------------------------------------------------- 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpangisvhqfieekQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTncaPPSQR--VVDFV 342
Cdd:cd14995 192 -------------------------GRILFSSRKQVTKMLAVVVVLFALLWMPYRTLVVYNSFAS---PPYLDlwFLLFC 243
                       330       340
                ....*....|....*....|....*.
gi 12229835 343 TWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14995 244 RTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
33-368 1.71e-15

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 76.42  E-value: 1.71e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQ---NFFVVSLAVADLTVALFVLPLNVaYRLL---NQWLLGSYLCQ 106
Cdd:cd15355   1 VLVTAIYLALFVVGTVGNSITLYTLARKKSLQHLQstvHYHLASLALSDLLILLLAMPVEL-YNFIwvhHPWAFGDAACR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 107 MWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL--LGWNDWPAQFTEDTPC 184
Cdd:cd15355  80 GYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLftMGEQNRSGTHPGGLIC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 185 TLTQE----RLFVVYSSSGSFFIPLIIMSVVYAKIffATKRRLRERTRKLGTLAVPAPPQRTSSRPLAELESVASQedet 260
Cdd:cd15355 160 TPIVDtstlKVVIQVNAFLSFLFPMLVISVLNTLI--ANQLTVMVNQAEQENQVCTIGGQRTVLSVSMEPGRVQSL---- 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 261 epspepeplssradkpangisvhqfieekqrislskeRKAARVLGVIMGVFVVCWLPFF---LMYAIVPFCTNcappSQR 337
Cdd:cd15355 234 -------------------------------------RHGVLVLRAVVIAFVVCWLPYHvrrLMFCYVSDEQW----TTF 272
                       330       340       350
                ....*....|....*....|....*....|....*...
gi 12229835 338 VVDFVTW-------LGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15355 273 LYDFYHYfymltnvLFYVSSAINPILYNLVSANFRQIF 310
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
37-365 3.45e-15

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 75.18  E-value: 3.45e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15088   5 SVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNQ 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL---------GWNDWPAQFTEDTPCTlt 187
Cdd:cd15088  85 FTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVyssliyfpdGTTFCYVSLPSPDDLY-- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 qerLFVVYSSSGSFFIPLIIMSVVYAKIFfatkrrlrertRKLGTLAVPAPPQRTSSRplaelesvasqedetepspepe 267
Cdd:cd15088 163 ---WFTIYHFILGFAVPLVVITVCYILIL-----------HRLARGVAPGNQSHGSSR---------------------- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 268 plssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFlmyaiVPFCTNCAPPSQRVVDFVTW--- 344
Cdd:cd15088 207 -----------------------------TKRVTKMVILIVVVFIVCWLPFH-----VVQLVNLAMNRPTLAFEVAYfls 252
                       330       340
                ....*....|....*....|...
gi 12229835 345 --LGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15088 253 icLGYANSCLNPFVYILVSENFR 275
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-367 4.35e-15

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 75.18  E-value: 4.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRS-VQNFFVVSLAVADLTvalFV--LPLNVAYRLLN-QWLLGSYLCQMWLTCD 112
Cdd:cd15190  15 VIYMLVFVLGLSGNGLVLWTVFRSKRKRRrSADTFIANLALADLT---FVvtLPLWAVYTALGyHWPFGSFLCKLSSYLV 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPC-------T 185
Cdd:cd15190  92 FVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVICdmdysgvV 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 186 LTQERLF-----VVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKlgtlavpappqrtssrplaelesvasqedet 260
Cdd:cd15190 172 SNESEWAwiaglGLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLRRK------------------------------- 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 261 epspepeplssradkpangisvhqfiEEKqrislsKERKAARVLGVIMGVFVVCWLPFFL---MYAIVPFctNCAPPSQR 337
Cdd:cd15190 221 --------------------------EDK------KKRRLLKIIITLVVTFALCWLPFHLvktLYALMYL--GILPFSCG 266
                       330       340       350
                ....*....|....*....|....*....|....*..
gi 12229835 338 VVDFV-------TWLGYVNSSLNPIIYTIYNKDFRTA 367
Cdd:cd15190 267 FDLFLmnahpyaTCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
41-222 1.44e-14

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 73.31  E-value: 1.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd15395   9 AVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITVSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 121 LNLCVIALDRYWAITDPINYaqKRTIRRVNTMIAAVWALSLVISVP----------PLLGWNDWPAQFTEDTPCT--LTQ 188
Cdd:cd15395  89 FSLVLIAIERHQLIINPRGW--RPNNRHAYVGIAVIWVLAVLTSLPflifqvltdePFKNVNVSLDAYKGKYVCLdqFPS 166
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 12229835 189 ERLFVVYSSS---GSFFIPLIIMSVVYAKIFFATKRR 222
Cdd:cd15395 167 DTIRLSYTTCllvLQYFGPLCFIFICYLKIYIRLKRR 203
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
37-368 1.96e-14

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 72.83  E-value: 1.96e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIIsVFTYRPLR---SVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQM--WLTc 111
Cdd:cd15002   4 ILLGVICLLGFAGNLMVIG-ILLNNARKgkpSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTadWFG- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 dILCCTSSILNLCVIALDRYWAITDPinyAQKRTI--RRVNTMIAAVWALSLVISVPPLL------------GWNDWPAQ 177
Cdd:cd15002  82 -HACMAAKSFTIAVLAKACYMYVVNP---TKQVTIkqRRITAVVASIWVPACLLPLPQWLfrtvkqsegvylCILCIPPL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 178 FTEDtpctltqERLFVVYSSSGSFFIPLIIMSVVYAKIFfatkRRLRERTRKLGTLavpappqRTSSRplaelesvasqe 257
Cdd:cd15002 158 AHEF-------MSAFVKLYPLFVFCLPLTFALFYFWRAY----GQCQRRGTKTQNL-------RNQIR------------ 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 258 detepspepeplssradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLP-FFLMYAIVPFCTNCAPPSQ 336
Cdd:cd15002 208 ---------------------------------------SRKLTHMLLSVVLAFTILWLPeWVAWLWLIHIKSSGSSPPQ 248
                       330       340       350
                ....*....|....*....|....*....|..
gi 12229835 337 RVVDFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15002 249 LFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
33-235 2.32e-14

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 72.44  E-value: 2.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIIsVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15114   1 VVALVLYAVVFLVGVPGNALVAW-VTGFEAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTL------ 186
Cdd:cd15114  80 LLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEKTVCVVdyggst 159
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 12229835 187 TQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRE---RTRKLGTLAV 235
Cdd:cd15114 160 GVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQksrRTLKVVTAVV 211
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
34-368 2.45e-14

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 72.50  E-value: 2.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLT-----VALFVLPLNVAYRLL-NQWLL--GSYLC 105
Cdd:cd15102   2 ATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLagaayLANILLSGARTLRLSpAQWFLreGSMFV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 106 QMwltcdilccTSSILNLCVIALDRYWAITDPINYAQKRTIRrVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCT 185
Cdd:cd15102  82 AL---------SASVFSLLAIAIERHLTMAKMKPYGASKTSR-VLLLIGACWLISLLLGGLPILGWNCLGALDACSTVLP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 186 LTQER--LFVVYSssgsFFIPLIIMSVVYAKIFFATKRRLRERTRklgtlavpappQRTSSRPLAELESVAsqedeteps 263
Cdd:cd15102 152 LYSKHyvLFCVTI----FAGILAAIVALYARIYCLVRASGRKATR-----------ASASPRSLALLKTVL--------- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfieekqrislskerkaarvlgVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT 343
Cdd:cd15102 208 ------------------------------------------IVLLVFIACWGPLFILLLLDVACPVKTCPILYKADWFL 245
                       330       340
                ....*....|....*....|....*
gi 12229835 344 WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15102 246 ALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
34-166 2.89e-14

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 72.49  E-value: 2.89e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLnvAYRLL---NQWLLGSYLCQMWLT 110
Cdd:cd15212   2 AQALVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPF--AFLTLfsrPGWLFGDRLCLANGF 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12229835 111 CDILCCTSSILNLCVIALDRYWAITDPINYAQKRtiRRVNTMIAAVWALSLVISVP 166
Cdd:cd15212  80 FNACFGIVSTLTMTLISFDRYYAIVRQPQGKIGR--RRALQLLAAAWLTALGFSLP 133
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
37-361 3.30e-14

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 72.52  E-value: 3.30e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALF-VLP---LNVAYRLLNQwllgSYLCQMWLTCD 112
Cdd:cd15386   5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFqVLPqliWEITYRFQGP----DLLCRAVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTiRRVNTMIAAVWALSLVISVPPLL-----------GWNDWPAQFTED 181
Cdd:cd15386  81 VLSMFASTYMLIMMTVDRYIAVCHPLRTLQQPS-RQAYLMIGATWLLSCILSLPQVFifslrevdqgsGVLDCWADFGFP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 182 tpctlTQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRklgTLAVPAPPQRTSSRPlAELESVASqedete 261
Cdd:cd15386 160 -----WGAKAYITWTTLSIFVLPVAILIVCYSLICYEICKNLKGKTQ---TSRSEGGGWRTQGMP-SRVSSVRT------ 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 262 pspepeplssradkpangisvhqfieekqrISLSKERkAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCapPSQRVVDF 341
Cdd:cd15386 225 ------------------------------ISRAKIR-TVKMTFVIVLAYIACWAPFFSVQMWSVWDENA--PDEDSSDF 271
                       330       340
                ....*....|....*....|....
gi 12229835 342 V----TWLGYVNSSLNPIIYTIYN 361
Cdd:cd15386 272 AftitMLLASLSSCCNPWIYMFFS 295
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
37-365 3.53e-14

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 72.07  E-value: 3.53e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVI-ISVFtyRPLRSVQNFFVVSLAVADLTVALFvLPLNVAYRLLN-QWLLGSYLCQMWLTCDIL 114
Cdd:cd15117   5 VIYSSAFVLGTLGNGLVIwVTGF--RMTRTVTTVCFLNLAVADFAFCLF-LPFSVVYTALGfHWPFGWFLCKLYSTLVVF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL------------------GWN---D 173
Cdd:cd15117  82 NLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVfrdtrkengcthcylnfdPWNetaE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 174 WPAQFTEDTPCTLTQERL--FVVysssgSFFIPLIIMSVVYAKIffaTKRRLRERTRKlgtlavpappqrtSSRPLaele 251
Cdd:cd15117 162 DPVLWLETVVQRLSAQVItrFVL-----GFLVPLVIIGGCYGLI---AARLWREGWVH-------------SSRPF---- 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 252 svasqedetepspepeplssradkpangisvhqfieekqrislskerkaaRVLGVIMGVFVVCWLPFFLMYAI-VPFCTN 330
Cdd:cd15117 217 --------------------------------------------------RVLTAVVAAFFLCWFPFHLVSLLeLVVILN 246
                       330       340       350
                ....*....|....*....|....*....|....*....
gi 12229835 331 CAPPSQRVVDFV----TWLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15117 247 QKEDLNPLLILLlplsSSLACVNSCLNPLLYVFVGRDFR 285
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
35-221 3.57e-14

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 72.08  E-value: 3.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAIILVT-IVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15086   2 VVAVFLGFILTFgFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPiNYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWN-------------DWPAQFTE 180
Cdd:cd15086  82 LFGIVSLISLAVLSYERYCTLLRP-TEADVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSsygpegpgttcsvQWTSRSAN 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 12229835 181 DTPCTLTqerLFVVysssgSFFIPLIIMSVVYAKIFFATKR 221
Cdd:cd15086 161 SISYIIC---LFIF-----CLLLPFLVMVYCYGRLLYAIKQ 193
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
33-360 3.73e-14

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 72.11  E-value: 3.73e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALF-VLPlNVAYRLLNQWLLGSYLCQMWLTC 111
Cdd:cd15388   1 QVEIAVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFqVLP-QLVWDITDRFRGPDVLCRLVKYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTiRRVNTMIAAVWALSLVISVPPLL---------GWNDWPAQFTEdt 182
Cdd:cd15388  80 QVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGR-ARWNGPVCVAWAISLILSLPQVFifskvevapGVYECWACFIE-- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 183 PCTLtqeRLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGtlAVPAPPQRTSSRPlaelESVAsqedetep 262
Cdd:cd15388 157 PWGL---KAYVTWITLVVFVLPTLIITVCQVLIFKEIHINIYLKSQIIV--AVVKKKQLLSSRA----SSVA-------- 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvhqfieekqriSLSKER-KAARVLGVIMGVFVVCWLPFFL--MYAIvpfcTNCAPPSQRVV 339
Cdd:cd15388 220 ------------------------------EVSKAMiKTVKMTLVIVLVYVLCWAPFFLvqLWSV----WDPKAPTEGAT 265
                       330       340
                ....*....|....*....|...
gi 12229835 340 dFV--TWLGYVNSSLNPIIYTIY 360
Cdd:cd15388 266 -FTilMLLASLNSCTNPWIYMAF 287
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
37-361 4.10e-14

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 72.16  E-value: 4.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALF-VLP---LNVAYRLLNQwllgSYLCQMWLTCD 112
Cdd:cd15385   5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFqVLPqlcWDITYRFYGP----DFLCRIVKHLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTiRRVNTMIAAVWALSLVISVPPLL-----------GWNDWPAQFTEd 181
Cdd:cd15385  81 VLGMFASTYMLVMMTADRYIAICHPLKTLQQPT-KRSYLMIGSAWALSFILSTPQYFifslseiengsGVYDCWANFIV- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 182 tPCTLtqeRLFVVYSSSGSFFIPLIIMSVVYAKIFF--------ATKRRLRERTRKLGTLAVPAPPQRTSSRplAELESV 253
Cdd:cd15385 159 -PWGI---KAYITWITISIFVVPVIILLTCYGFICYniwrnikcKTRRGLSDNALKNILLAVCVSSVKTISR--AKIRTV 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 254 asqedetepspepeplssradkpangisvhqfieekqrislskerkaaRVLGVIMGVFVVCWLPFFL--MYAIVPFCTNC 331
Cdd:cd15385 233 ------------------------------------------------KMTFVIVLAYIVCWAPFFTiqMWSVWDQNFPW 264
                       330       340       350
                ....*....|....*....|....*....|
gi 12229835 332 APPSQRVVDFVTWLGYVNSSLNPIIYTIYN 361
Cdd:cd15385 265 DESENTAVTITALLASLNSCCNPWIYMFFS 294
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
42-368 4.44e-14

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 71.77  E-value: 4.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLR---SVQNFFVVSLAVADLtVALFVLPLNVAYRLLNQ-WLLGSYLCQMWLTCDILCCT 117
Cdd:cd15338  10 ICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDL-LFLLGMPFLIHQLLGNGvWHFGETMCTLITALDTNSQI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP-----PLLGWNDWPAQFTEDTPCTLTQERLF 192
Cdd:cd15338  89 TSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPvwmyaGLMPLPDGSVGCALLLPNPETDTYWF 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFfatkrrlrertRKLGTLAVPAPpqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd15338 169 TLYQFFLAFALPLVVICVVYFKIL-----------QNMASTVAPLP---------------------------------- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpangisvhqfieekQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGYVNSSL 352
Cdd:cd15338 204 -----------------QRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAHLSIDRPSLAFLYAYNVAISMGYANSCI 266
                       330
                ....*....|....*.
gi 12229835 353 NPIIYTIYNKDFRTAF 368
Cdd:cd15338 267 NPFLYIMLSETFKRQF 282
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
36-368 4.80e-14

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 71.69  E-value: 4.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQM--WLTCDI 113
Cdd:cd15000   3 SSMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLegFLEGSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LccTSSILNLCVIALDRYWAITDPINyaQKRTIRRVNTMIAAVWALSLVISVPPLL-------GWNDWPAQF-TEDTPCT 185
Cdd:cd15000  83 L--LASVLALCAVSYDRLTAIVLPSE--ARLTKRGAKIVIVITWIVGLLLALPLAIyrsyrerQWKNFLETYcAENTQVL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 186 LTQERLFVVYsssgSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGtlavpappqrtssrplaelesvasqedetepspe 265
Cdd:cd15000 159 PIYWHVIITV----LVWLPLGIMLICYSAIFWKLDKYERRVLRREH---------------------------------- 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 266 peplssradkpangisvhqfieekqRISLSKERKAARVLGVIMGVFVVCWLPF----FLMYAIVP--FCTNCAPPSQRVV 339
Cdd:cd15000 201 -------------------------PSVVRYKKKAAKTLFIVLITFVVCRIPFtaliFYRYKLVPndNTQNSVSGSFHIL 255
                       330       340       350
                ....*....|....*....|....*....|
gi 12229835 340 DFVT-WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15000 256 WFASkYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
38-215 4.97e-14

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 71.71  E-value: 4.97e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtvaLFV--LPLNVAYRlLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15172   6 IYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADI---LFVltLPFWAVYE-AHQWIFGNFSCKLLRGIYAIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAI---TDPINYaQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPC-------- 184
Cdd:cd15172  82 FYSGMLLLACISVDRYIAIvqaTKSFRL-RSRTLAYSKLICAAVWLLAILISLPTFIFSEVYDFGLEEQYVCepkypkns 160
                       170       180       190
                ....*....|....*....|....*....|..
gi 12229835 185 TLTQERLFVVYSSSG-SFFIPLIIMSVVYAKI 215
Cdd:cd15172 161 TAIMWKLLVLSLQVSlGFFIPLLVMIFCYSFI 192
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
38-365 5.70e-14

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 72.29  E-value: 5.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLN-VAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15217   6 LLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVlVSIRNGSAWTYSVLSCKIVAFMAVLFC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWpaQFTEDTPCTLTQERLFVVYS 196
Cdd:cd15217  86 FHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTY--KFIREEDQCIFEHRYFKAND 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 197 SSGSFFIPLIIM---SVVYAKIFFatkrrLRERTRKLGTLA-VPAPPQR-TSSRPLAELESVASQedetepspepEPLSS 271
Cdd:cd15217 164 TLGFMLMLAVLIvatHIVYGKLLL-----FEYRHRKMKPVQmVPAISQNwTFHGPGATGQAAANW----------IAGFG 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 RADKPANGISVHQFIEEKQRISL-----SKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPsQRVVDFVTWLG 346
Cdd:cd15217 229 RGPMPPTLLGIRQNAHTANRRLLgmeefKAEKRLGRMFYVITLSFLVLWSPYIVACYWRVFVKACSIP-HRYLSTAVWMS 307
                       330
                ....*....|....*....
gi 12229835 347 YVNSSLNPIIYTIYNKDFR 365
Cdd:cd15217 308 FAQAGVNPIVCFLLNKDLK 326
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
37-365 7.65e-14

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 70.94  E-value: 7.65e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPL-NVAYRLLNQWLLGSYLCQmwLTCDILC 115
Cdd:cd15193   5 ILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADL-VFVLTLPFwAASTALGGQWLFGEGLCK--LSSFIIA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CT--SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpaqFTEDTPCTLTQERLFV 193
Cdd:cd15193  82 VNrcSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRN-----LINESVCVEDSSSRFF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 VYSSSGSFFI----PLIIMSVVYAKIFfatkRRLRertrklgtlavpappqrtssrplaelesvasqedetepspepepl 269
Cdd:cd15193 157 QGISLATLFLtfvlPLIVILFCYCSIL----VRLR--------------------------------------------- 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssraDKPANGISVHQfieekqrislsKERKAARVLGVIMGVFVVCWLPF------FLMYAIVPFCTNCAPPS--QRVVDF 341
Cdd:cd15193 188 ----RHFHGAKRTGR-----------RRRNSLRIVFAIVTAFVLSWLPFntlkavRLLLELGGGVLPCHTTVaiRQGLTI 252
                       330       340
                ....*....|....*....|....
gi 12229835 342 VTWLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15193 253 TACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
47-229 9.08e-14

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 70.95  E-value: 9.08e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  47 IVGNSLVIIsVFTYRPLRSVQNFFVVSLAVADLTVAlFVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILCCTSSILNLCV 125
Cdd:cd15116  15 VLGNGLVIF-ITGFKMKKTVNTVWFLNLAVADFLFT-FFLPFSIAYTAMDfHWPFGRFMCKLNSFLLFLNMFTSVFLLTV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 126 IALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPC------------------TLT 187
Cdd:cd15116  93 ISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKIICfnnfslsgdnsspevnqlRNM 172
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 12229835 188 QERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRK 229
Cdd:cd15116 173 RHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSK 214
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
36-368 1.15e-13

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 70.30  E-value: 1.15e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLL---GSYLCQMWLTCD 112
Cdd:cd15352   4 AEVFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLvisDQFIQHMDNVFD 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTS---SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVppllgwndwpaqftedtpctltqe 189
Cdd:cd15352  84 SMICISlvaSICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGI------------------------ 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 rLFVVYSSSGS--------FFIPLIIMSVVYAKIFFATKRRLReRTRKLGTLAVPAPPQRTSsrplaelesvasqedete 261
Cdd:cd15352 140 -VFIVYSESKTvivclitmFFAMLVLMATLYVHMFLFARLHVK-RIAALPPAVDGAPQQRSC------------------ 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 262 pspepeplssradkpangisvhqfieekqrislskeRKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDF 341
Cdd:cd15352 200 ------------------------------------MKGAVTITILLGVFIVCWAPFFLHLILIISCPHNPYCLCYTSHF 243
                       330       340
                ....*....|....*....|....*....
gi 12229835 342 VTWLGYV--NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15352 244 NTYLVLImcNSVIDPLIYAFRSLEMRKTF 272
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
30-185 1.20e-13

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 70.74  E-value: 1.20e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  30 GETVAATALLlaiILVTIVGNSLVIISVFTYRPLRSVQNF--FVVSLAVADLTVALFVLPLNVAYRLLNQ-WLLGSYLCQ 106
Cdd:cd14981   1 GESPAPPALM---FVFGVLGNLLALIVLARSSKSHKWSVFyrLVAGLAITDLLGILLTSPVVLAVYASNFeWDGGQPLCD 77
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12229835 107 MWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFtedtPCT 185
Cdd:cd14981  78 YFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLLGLGSYVLQY----PGT 152
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
42-368 1.30e-13

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 70.70  E-value: 1.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15124  10 IILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVGVSVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgWNDWPAQFTEDTPCTLTQ-------ERLFVV 194
Cdd:cd15124  90 TLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAV-FSDLHPFYDKSTNKTFVScapyphsNELHPK 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 195 YSSSGSFF----IPLIIMSVVYakiFFATKRRLRErtrklgtlavpappqrtssrplaelesvasqedetepspepepls 270
Cdd:cd15124 169 IHSMASFLifyvIPLSIISVYY---YFIAKNLIRS--------------------------------------------- 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpANGISVHQFIEEKQRISlSKERKAARVLgVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqrVVDFVT-----WL 345
Cdd:cd15124 201 ------AYNLPVEGNVHVRRQIE-SRKRLAKTVL-VFVGLFAFCWLPNHIIYLYRSYHYSEVDTS--MLHFVSsicarIL 270
                       330       340
                ....*....|....*....|...
gi 12229835 346 GYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15124 271 AFTNSCVNPFALYLLSKSFRKQF 293
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
38-367 1.50e-13

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 69.96  E-value: 1.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRP-LRSVQNFFVVSLAVADLtVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDIlcc 116
Cdd:cd15962   5 IMLCISGTVIACENAIVVAIIFYTPtLRTPMFVLIGSLATADL-LAGCGLILNFVFQYVIQSETISLITVGFLVASF--- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpaQFTEDTPCT----LTQERLF 192
Cdd:cd15962  81 TASVSSLLAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGWN----CLEERASCSivrpLTKSNVT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVyssSGSFFIPLIIMSVVYAKIFFATKRRlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd15962 157 LL---SASFFFIFILMLHLYIKICKIVCRH-------------------------------------------------- 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 adkpANGISVHQ-FIEEKQRISlskERKAARVLGVIMGVFVVCWLPFFLmyaivpFCTNCAPPSQRVVDFVTWL-GYVNS 350
Cdd:cd15962 184 ----AHQIALQQhFLTASHYVA---TKKGVSTLAIILGTFGASWLPFAI------YCVVGDHEYPAVYTYATLLpATYNS 250
                       330
                ....*....|....*..
gi 12229835 351 SLNPIIYTIYNKDFRTA 367
Cdd:cd15962 251 MINPIIYAYRNQEIQRS 267
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
38-222 2.41e-13

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 69.86  E-value: 2.41e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVG---NSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDIL 114
Cdd:cd15396   3 LIIAYSVVTIVGlfgNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILNLCVIALDRYWAITDPINYaqKRTIRRVNTMIAAVWALSLVISVPPLLGWN---------DWPAQFTEDTPCT 185
Cdd:cd15396  83 SVSVSIFSLVLIAIERYQLIVNPRGW--KPSASHAYWGIVLIWLFSLMISIPFLIFHQltdepfrnlSSHSDFYKDKVVC 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 12229835 186 L------TQERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRR 222
Cdd:cd15396 161 IeawpseTERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKR 203
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
50-367 2.69e-13

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 69.43  E-value: 2.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  50 NSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLplnvaYRLLNQWLLGSYLCQMWLTCDILCC-TSSILNLCVIAL 128
Cdd:cd15100  18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGLI-----LHFVFRYCVYSEALSLVSVGLLVAAfSASVCSLLAITV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 129 DRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpaQFTEDTPCT----LTQERLFVVyssSGSFFIP 204
Cdd:cd15100  93 DRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWN----CLREGSSCSvvrpLTKNHLAVL---AVAFLLV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 205 LIIMSVVYAKIFFATKRRLRERTRKLGTLavpAPPQRTSSrplaelesvasqedetepspepeplssradkpangisvhq 284
Cdd:cd15100 166 FALMLQLYAQICRIVLRHAHQIALQRHFL---APSHYVAT---------------------------------------- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 285 fieekqrislskeRKAARVLGVIMGVFVVCWLPFFLmyaivpFCTNCAPPSQRVVDFVTWL-GYVNSSLNPIIYTIYNKD 363
Cdd:cd15100 203 -------------RKGVSTLALILGTFAACWIPFAV------YCLLGDGSSPALYTYATLLpATYNSMINPIIYAFRNQD 263

                ....
gi 12229835 364 FRTA 367
Cdd:cd15100 264 IQKV 267
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
40-228 3.72e-13

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 68.97  E-value: 3.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRLL-NQWLLGSYLCQMWLTCDILCCTS 118
Cdd:cd15161   8 ILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVL-ILPMRLVYHLSgNHWPFGEVPCRLAGFLFYLNMYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 119 SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALsLVISVPPLLGWNDwPAQFTEDTPCT-LTQER--LFVVY 195
Cdd:cd15161  87 SLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVI-VTVAMAPLLVSPQ-TVEVNNTTVCLqLYREKasRGALV 164
                       170       180       190
                ....*....|....*....|....*....|...
gi 12229835 196 SSSGSFFIPLIIMSVVYAKIFFATKRRLRERTR 228
Cdd:cd15161 165 SLAVAFTIPFVTTVTCYLLIIRSLRTGKREEKP 197
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
35-368 4.88e-13

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 68.43  E-value: 4.88e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLL---GSYLCQMWLTC 111
Cdd:cd15354   3 AAEVFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLvieDAFVRHIDNVF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLC---VIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSlvisvppllgwndwpaqftedTPCTLtq 188
Cdd:cd15354  83 DSLICISVVASMCsllAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFC---------------------TGCGI-- 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 189 erLFVVYSSSGSFFIPLIIMsvvyakiFFATKRRLRERTRKLGTLAvpappqRTSSRPLAELESVASQedetepspepep 268
Cdd:cd15354 140 --IFILYSESTYVIICLITM-------FFAMLFLMVSLYIHMFLLA------RTHVKRIAALPGYNSV------------ 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lssradkpangisvhqfieeKQRISLskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGYV 348
Cdd:cd15354 193 --------------------RQRTSM----KGAVTLTILLGIFIVCWAPFFLHLILMISCPQNLYCVCFMSHFNMYLILI 248
                       330       340
                ....*....|....*....|..
gi 12229835 349 --NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15354 249 mcNSVIDPLIYAFRSQEMRKTF 270
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
42-221 5.85e-13

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 69.04  E-value: 5.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835   42 IILVTIVGNSLVIIsVFTYRPLRSVQNFFVVSLAVADLtvaLFV--LPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:PHA03087  50 IFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDL---LFVmtLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNS 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpaqfTEDTPCTLTQerlFVVYSSSG 199
Cdd:PHA03087 126 MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYT------TKKDHETLIC---CMFYNNKT 196
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 12229835  200 --------------SFFIPLIIMSVVYAKIFFATKR 221
Cdd:PHA03087 197 mnwklfinfeiniiGMLIPLTILLYCYSKILITLKG 232
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
33-228 6.95e-13

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 68.29  E-value: 6.95e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRP--LRSVQNFFVVSLAVADLTVaLFVLPLNVAYRLLNQWLLGSYLCQMwlt 110
Cdd:cd15122   1 ATGTIFLLLAALLGLPGNGFIIWSILWKMKarGRSVTCILILNLAVADGAV-LLLTPFFITFLTRKTWPFGQAVCKA--- 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 111 CDILCCTS---SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLT 187
Cdd:cd15122  77 VYYLCCLSmyaSIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICEPC 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 12229835 188 Q----ERLF-VVYSSSGSFFIPLIIMSVVYAKIFFATK-RRLRERTR 228
Cdd:cd15122 157 HasrgHAIFhYTFETLVAFVLPFGVILFSYSVILVRLKgARFRRRAR 203
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
44-365 7.19e-13

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 67.87  E-value: 7.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIIsVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILCCTSSILN 122
Cdd:cd15115  12 LLGVPGNGLVIW-VAGLKMKRTVNTIWFLNLAVADLLCCL-SLPFSIAHLLLNgHWPYGRFLCKLLPSIIVLNMFASVFT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 123 LCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgwndWPAQFTED--TPCTLTQERLFVVYSSSGS 200
Cdd:cd15115  90 LTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFI----YRTTVTDGnhTRCGYDFLVAITITRAVFG 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 201 FFIPLIIMSVVYAKIFFatkRRLRERTRKlgtlavpappqrtssrplaelesvasqedetepspepeplssradkpangi 280
Cdd:cd15115 166 FLLPLLIIAACYSFIAF---RMQRGRFAK--------------------------------------------------- 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 281 svhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVD-FVTWLGYVNSSLNPIIYTI 359
Cdd:cd15115 192 ---------------SQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLSKVLMSWDhLSIALAYANSCLNPVLYVF 256

                ....*.
gi 12229835 360 YNKDFR 365
Cdd:cd15115 257 MGKDFK 262
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
37-171 1.07e-12

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 67.88  E-value: 1.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVT-IVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15075   4 SIIMAVFSIAsVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAFF 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTiRRVNTMIAAVWALSLVISVPPLLGW 171
Cdd:cd15075  84 GIAALCTVAVIAVDRLFVVCKPLGTLTFQT-RHALAGIASSWLWSLIWNTPPLFGW 138
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
38-215 1.24e-12

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 67.49  E-value: 1.24e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVT-IVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLnVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15173   5 CMYSVMFVTgLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADL-LFLCTLPF-WAYSAAHEWIFGTVMCKITNGLYTINL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAI---TDPINYAQKR-TIRRVNTMIaaVWALSLVISVPpllgwndwpaQFTEDTPCTLTQERLF 192
Cdd:cd15173  83 YSSMLILTCITVDRFIVIvqaTKAHNCHAKKmRWGKVVCTL--VWVISLLLSLP----------QFIYSEVRNLSSKICS 150
                       170       180       190
                ....*....|....*....|....*....|....*
gi 12229835 193 VVYSSSG------------SFFIPLIIMSVVYAKI 215
Cdd:cd15173 151 MVYPPDAievvvniiqmtvGFFLPLLAMIICYSVI 185
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
35-368 1.26e-12

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 67.24  E-value: 1.26e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLG--SYLCQMWLTCD 112
Cdd:cd15353   3 SPEVFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDaqSFTVNIDNVID 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTS---SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVppllgwndwpaqftedtpctltqe 189
Cdd:cd15353  83 SVICSSllaSICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGV------------------------ 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 rLFVVYSSSGS--------FFIPLIIMSVVYAKIFFATkrrlRERTRKLGTLavpappqrtssrplaelesvasqedete 261
Cdd:cd15353 139 -LFIIYSDSSVviiclismFFTMLALMASLYVHMFLLA----RLHIKRIAVL---------------------------- 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 262 pspepeplssradkPANGiSVHQFIEEKQRISLSkerkaarvlgVIMGVFVVCWLPFFLMYAIVPFCtncaPPSQRVVDF 341
Cdd:cd15353 186 --------------PGTG-PIRQGANMKGAITLT----------ILLGVFVVCWAPFFLHLIFYISC----PRNPYCVCF 236
                       330       340       350
                ....*....|....*....|....*....|...
gi 12229835 342 VTWLGY------VNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15353 237 MSHFNMylilimCNSVIDPLIYAFRSQELRKTF 269
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-368 1.99e-12

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 66.78  E-value: 1.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNF-FVVSLAVADLTVALFVLPLNVAYRLLNQwLLGSYLCQMWLTC 111
Cdd:cd15099   1 KAIAVLCFLAGPVTFLENILVLLTILSSTALRRRPSYlFIGSLALADMLASVIFTISFLDFHVFHQ-RDSRNLFLFKLGG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAqfteDTPCTLTQERL 191
Cdd:cd15099  80 VTMAFTASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMGWRCKTW----DSPCSRLFPYI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGSFFIPLIIMSVVYAKIFF---ATKRRLRERTRKLGTLAVPAPPQrtssrplaelesvasqedetepspepep 268
Cdd:cd15099 156 DRHYLASWTGLQLVLLFLIIYAYPYIlwkAHRHEANMGGPKLGRQQVKGQAR---------------------------- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lsSRADkpangisvhqfieekqrISLskerkaARVLGVIMGVFVVCWLPfFLMYAIVPFCTNCAPPSQRVVDFVTWLGYV 348
Cdd:cd15099 208 --MRMD-----------------IRL------AKTLSLILLVLAICWLP-VLAFMLVDVRVTLTNKQKRMFAFCSMLCLV 261
                       330       340
                ....*....|....*....|
gi 12229835 349 NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15099 262 NSCVNPIIYALRSRELRGAM 281
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
44-171 2.06e-12

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 66.84  E-value: 2.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPL---NVAYR---LLN--QWlLGSYLCQMWLTCDILC 115
Cdd:cd15137  12 IIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIasvDLYYRgvyIKHdeEW-RSSWLCTFAGFLATLS 90
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835 116 CTSSILNLCVIALDRYWAITDPinYAQKR-TIRRVNTMIAAVWALSLVISVPPLLGW 171
Cdd:cd15137  91 SEVSVLILTLITLDRFICIVFP--FSGRRlGLRRAIIVLACIWLIGLLLAVLPLLPW 145
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
40-367 2.14e-12

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 66.77  E-value: 2.14e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15348   8 LAVCAFIVLENLIVLLALWRNKKFHSPMFYLLGSLTLSDL-LAGAAYAANILMSGANTLKLTPALWFLREGGVFITLTAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDpINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdWPAQFTEDTPCTLTQERLFVVYSSSg 199
Cdd:cd15348  87 VFSLLAIAIERHITMVR-MKPYPGDKRGRMFLLIGAAWLVSILLGVLPILGWN-CLGNLDACSTVLPLYAKSYILFCIT- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 200 SFFIPLIIMSVVYAKIFfatkRRLRERTRKLGTLAVPAPPQRTSSRPLAELESVAsqedetepspepeplssradkpang 279
Cdd:cd15348 164 VFLAILAAIVVLYARIY----RIVKANSQRLGALPTRKGRARRSQKYLALLKTVT------------------------- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 280 isvhqfieekqrislskerkaarvlgVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLGYVNSSLNPIIYTI 359
Cdd:cd15348 215 --------------------------IVLGTFVACWLPLFLLLLLDVSCPAQACPVLLKADYFLGLAMINSLLNPIIYTL 268

                ....*...
gi 12229835 360 YNKDFRTA 367
Cdd:cd15348 269 TSRDMRRA 276
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
33-368 2.14e-12

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 66.86  E-value: 2.14e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNF-FVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCqMWLTC 111
Cdd:cd15340   1 LAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYhFIGSLAVADLLGSVIFVYSFLDFHVFHRKDSPNVFL-FKLGG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYaqKRTIRRVNTMIA--AVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQE 189
Cdd:cd15340  80 VTASFTASVGSLFLTAIDRYISIHRPLAY--KRIVTRTKAVIAfcVMWTIAIVIAVLPLLGWNCKKLNSVCSDIFPLIDE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 190 RLFVVYSSSGSffipLIIMSVVYAKIFFATKRRlRERTRKLgtlavpappQRTSSRPLAelesVASQEDEtepspepepl 269
Cdd:cd15340 158 TYLMFWIGVTS----VLLLFIVYAYMYILWKAH-HHAVRML---------QRGTQKSII----VYTSEDG---------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangiSVHQFIEEKQRISLskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFcTNCAPPSQRVVDFVTWLGYVN 349
Cdd:cd15340 210 -----------KVQTTRPDQTRMDI----RLAKTLVLILVVLIICWGPLLAIMVYDVF-GKMNKLIKTVFAFCSMLCLLN 273
                       330
                ....*....|....*....
gi 12229835 350 SSLNPIIYTIYNKDFRTAF 368
Cdd:cd15340 274 STVNPIIYALRSKDLRHAF 292
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
41-368 2.67e-12

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 66.69  E-value: 2.67e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd15087   9 VICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTL-VLPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 121 LNLCVIALDRYWAITDPIN--YAQKRTIRRVNTMIAAVWALSLVISVP-PLLGWNDWPAQFTedTPCTLT---QERLFV- 193
Cdd:cd15087  88 YFLTVMSVDRYLVVLATVRsrRMPYRTYRAAKIVSLCVWLLVTIIVLPfTVFAGVYSNELGR--KSCVLSfpsPESLWFk 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 ---VYSSSGSFFIPLIIMSVVYAKIFFATKR-RLRERTRKLGtlavpappqrtssrplaelesvasqedetepspepepl 269
Cdd:cd15087 166 asrIYTLVLGFAIPVSTICILYTMMLYKLRNmRLNSNAKALD-------------------------------------- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfiEEKQRISLskerkaarVLGVIMGVFVVCWLPFFLmyAIVPFCTNCAPPSQRVVD---FVTWLG 346
Cdd:cd15087 208 -----------------KAKKKVTL--------MVLVVLAVCLFCWTPFHL--STVVALTTDLPQTPLVIGisyFITSLS 260
                       330       340
                ....*....|....*....|..
gi 12229835 347 YVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15087 261 YANSCLNPFLYAFLDDSFRKSF 282
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
42-229 2.69e-12

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 67.73  E-value: 2.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835   42 IILVTIVGNSLVIISVFtYRPLRSVQNFFVVSLAVADLtvaLFVLPLN-VAYRLLNQWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:PHA02638 108 IFILGLFGNAAIIMILF-CKKIKTITDIYIFNLAISDL---IFVIDFPfIIYNEFDQWIFGDFMCKVISASYYIGFFSNM 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  121 LNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWND----WPAQFTEDT----PCTLTQERLF 192
Cdd:PHA02638 184 FLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFEAsniiFSAQDSNETisnyQCTLIEDNEK 263
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 12229835  193 VVYSSSG----------SFFIPLIIMSVVYAKIFFATKRRLRERTRK 229
Cdd:PHA02638 264 NNISFLGrilqfeinilGMFIPIIIFAFCYIKIILKLKQLKKSKKTK 310
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
45-365 2.83e-12

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 66.38  E-value: 2.83e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  45 VTIVGNSLVIISVFTYRPlRSVQNFFVVSLAVADLtVALFVLPLNV-AYRLLNQWLLGSYLCQMWLTCDILCCTSSILNL 123
Cdd:cd15339  13 TGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADL-VHIIVMPFLIhQWARGGEWVFGSPLCTIITSLDTCNQFACSAIM 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 124 CVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWN-DWPAQFTEDTPCTLT---QERLFVVYSSSG 199
Cdd:cd15339  91 TAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKvIKFRDGLESCAFNLTspdDVLWYTLYQTIT 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 200 SFFIPLIIMSVVYAKIFFATKRRLReRTRKLGTLAVPAPPQRTssrplaelesvasqedetepspepeplssradkpang 279
Cdd:cd15339 171 TFFFPLPLILICYILILCYTWEMYR-KNKKAGRYNTSIPRQRV------------------------------------- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 280 isvhqfieekqrislskeRKAARVLGVIMGVFVVCWLPFFLMYAIvpfctNCAPPSQRVVDFVTW-----LGYVNSSLNP 354
Cdd:cd15339 213 ------------------MRLTKMVLVLVGVFLVSAAPYHVIQLV-----NLSVSQPTLAFYVSYylsicLSYASSSINP 269
                       330
                ....*....|.
gi 12229835 355 IIYTIYNKDFR 365
Cdd:cd15339 270 FLYILLSGNFR 280
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
41-235 3.05e-12

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 66.40  E-value: 3.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtvaLFVLPLNV-AYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15186   9 LVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDL---LFVATLPFwTHYLINEWGLHNAMCKLTTAFFFIGFFGG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL--------GWNDWPAQFTEDTPCTLTQERL 191
Cdd:cd15186  86 IFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMftkmkeneCLGDYPEVLQEIWPVLRNVELN 165
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 12229835 192 FVvysssgSFFIPLIIMSVVYAKI---FFATKRRLRERTRKLGTLAV 235
Cdd:cd15186 166 FL------GFLLPLLIMSYCYFRIiqtLFSCKNHKKARAIKLILLVV 206
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
45-368 3.33e-12

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 66.37  E-value: 3.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  45 VTIVGNSLVIISVFTYRPLR--SVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILN 122
Cdd:cd14976  13 VGLLGNLLVLYLLKSNKKLRqqSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKLNMYSSIFF 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 123 LCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP-PLLGWNDWPAqfTEDTPCTLTQERLFVVYSSSG-- 199
Cdd:cd14976  93 LTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPeAIFSTDTWSS--VNHTLCLLRFPKNSSVTRWYNwl 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 200 ----------SFFIPLIIMSVVYAKIFFATKRRLRERTRKLgtlavpappqrtssrplaelesvasqedetepspepepl 269
Cdd:cd14976 171 gmyqlqkvvlGFFLPLGIITLSYLLLLRFLQRKRGGSKRRK--------------------------------------- 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangisvhqfieekqrislskeRKAARVLGVIMGVFVVCWLPF--------FLMYAIVPFCTNCAPPSQRVVDF 341
Cdd:cd14976 212 ----------------------------SRVTKSVFIVVLSFFICWLPNqalslwsaLIKFDDVPFSDAFFAFQTYAFPV 263
                       330       340
                ....*....|....*....|....*..
gi 12229835 342 VTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14976 264 AICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
42-215 3.49e-12

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 66.33  E-value: 3.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLnVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15175  10 ICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADI-LFLLTLPF-WAASAAKKWVFGEEMCKAVYCLYKMSFFSGML 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRT----IRRVNTmiAAVWALSLVISVPPLL--GWNDWPAQFTedtpCTLTQERLFVVY 195
Cdd:cd15175  88 LLMCISIDRYFAIVQAASAHRHRSravfISKVSS--LGVWVLAFILSIPELLysGVNNNDGNGT----CSIFTNNKQTLS 161
                       170       180
                ....*....|....*....|....*.
gi 12229835 196 SSSGS------FFIPLIIMSVVYAKI 215
Cdd:cd15175 162 VKIQIsqmvlgFLVPLVVMSFCYSVI 187
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
34-368 3.56e-12

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 65.99  E-value: 3.56e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLT-----VALFVLPLNVAYRLLN-QWLL--GSYLC 105
Cdd:cd15347   2 VASIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLagvafIANILLSGSVTFRLTPvQWFIreGTAFI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 106 QMwltcdilccTSSILNLCVIALDRYWAITDPINYAQKRTIRRVnTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCT 185
Cdd:cd15347  82 TL---------SASVFSLLAIAIERHVAITKVKLYGSDKNCRMV-LLIGACWVISIVLGGLPILGWNCIGNLEDCSTVLP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 186 LTQER--LFVVysssGSFFIPLIIMSVVYAKIFFATKrrlrertrklgtlavpappqrtssrplaelesvasqedeteps 263
Cdd:cd15347 152 LYSKHyiLFVV----TIFSIILLSIVILYVRIYCIVR------------------------------------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangiSVHQFIEEKQRISLSKerkaarVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT 343
Cdd:cd15347 185 -----------------SSHAEMAAPQTLALLK------TVTIVLGVFIVCWLPAFIILLLDTSCKVKSCPILYKADYFF 241
                       330       340
                ....*....|....*....|....*
gi 12229835 344 WLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15347 242 SVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-360 3.70e-12

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 66.38  E-value: 3.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALF-VLPlNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15387   5 TVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFqVLP-QLIWDITFRFYGPDFLCRLVKYLQVVG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRrvnTMIAAVWALSLVISVPPLL---------GWNDWPAQFTEdtPCTL 186
Cdd:cd15387  84 MFASTYMLLLMSIDRCLAICQPLRSLHRRSDR---VYVLFSWLLSLVFSIPQVHifslrevgnGVYDCWADFIQ--PWGP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 tqeRLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLAVPAPPQRTSSrpLAELESVasqedetepspep 266
Cdd:cd15387 159 ---KAYITWITLSVYIIPVLILSVCYGLISFKIWQNVKLKTRRETKTPLSSAASGGAA--LARVSSV------------- 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangisvhqfieekQRISLSKERkAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNcAPPSQRVVDFVTWLG 346
Cdd:cd15387 221 -----------------------KLISKAKIR-TVKMTFVIVLAYIVCWTPFFFVQMWSVWDPN-APKEASPFIIAMLLA 275
                       330
                ....*....|....
gi 12229835 347 YVNSSLNPIIYTIY 360
Cdd:cd15387 276 SLNSCCNPWIYMFF 289
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
50-246 6.22e-12

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 65.64  E-value: 6.22e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  50 NSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLP-----------LNVAYRLLNQWLLGsylcqMWLTCdilccts 118
Cdd:cd15211  17 NVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPqeavlgstgtlLVLGYRLFREGLLF-----LGLTV------- 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 119 SILNLCVIALDRYWAITD-PINYAQKRTIRRVNTMIAAVWALSLVIsVPPLLGWNDWPAQftedtPCTLTQERLFVVYSS 197
Cdd:cd15211  85 SLLSHSLIALNRYVLITKlPAVYQALYQKRNTEWMIALSWALALGL-LLPWLTSFRYPTK-----SCHDSADGSFAVVSV 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 198 SGSFFIPLIIMSVVYAKI------FFATKRRLRERTRKLGTLAVPAPPQRTSSRP 246
Cdd:cd15211 159 LSSRYPALLLAFTVLGQTalvlhcYFGIFRRVQISVKRVSVLNFQIVNNLPYSRP 213
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
34-365 6.27e-12

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 65.24  E-value: 6.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15008   1 AASLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRtiRRVNTMIAAVWALSLVISVPPLLGWNdwpaqfTEDTPCTltqeRLFV 193
Cdd:cd15008  81 LTPGVQIYVLLSICVDRFYTIVYPLSFKVSR--EKAKKMIAASWLFDAAFVSPALFFYG------SNWGPHC----NFFL 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 VYSSSGSFF--IPLIIMSVVYAKIFFATKRRLRERTRKLGTlavpappqrtssrplaelesvasqedetepspepeplss 271
Cdd:cd15008 149 PDSWDGAAYaiIHLLVGFLVPSILIILFYQKVIKYIWRIGT--------------------------------------- 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpaNGISVHQFIEEKQRISLskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNcAPPSQRVVDFVTWLGYVNSS 351
Cdd:cd15008 190 ------DGRTVRRTMNIVPRTKV----KTIKMFLMLNSMFLLSWLPFYVVQLWHPRESD-YRQSSLVFLAVTWISFSSSA 258
                       330
                ....*....|....
gi 12229835 352 LNPIIYTIYNKDFR 365
Cdd:cd15008 259 SKPTLYSVYNANFR 272
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
33-374 7.40e-12

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 65.27  E-value: 7.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15084  11 LTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMV 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTiRRVNTMIAAVWALSLVISVPPLLGWNDW----------PAQFTEDT 182
Cdd:cd15084  91 SLTGIVGLWSLAILAFERYLVICKPMGDFRFQQ-RHAVSGCAFTWGWSLLWTSPPLFGWSSYvpeglrtscgPNWYTGGT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 183 PCTLTQERLFVVysssgSFFIPLIIMSVVYAKIFFAtkrrlrertrklgtlavpappqrtssrplaeLESVASQEDETep 262
Cdd:cd15084 170 NNNSYILALFVT-----CFALPLSTIIFSYSNLLLT-------------------------------LRAVAAQQKES-- 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvhqfiEEKQRislsKERKAARVLGVIMGVFVVCWLPfFLMYAIVPFCTNCAPPSQRVVDFV 342
Cdd:cd15084 212 ------------------------ETTQR----AEKEVTRMVIAMVMAFLICWLP-YATFAMVVATNKDVVIQPTLASLP 262
                       330       340       350
                ....*....|....*....|....*....|..
gi 12229835 343 TWLGYVNSSLNPIIYTIYNKDFRTAFSRLLRC 374
Cdd:cd15084 263 SYFSKTATVYNPIIYVFMNKQFRSCLLELLCC 294
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
50-365 8.58e-12

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 64.92  E-value: 8.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  50 NSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCdilcCTSSILNLCVIALD 129
Cdd:cd15960  18 NAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFVAIYVMNSEAVTLCSAGLLLAA----FSASVCSLLAITVD 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 130 RYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWN--DWPAQFTEDTPCTLTQERLFVVysssgSFFIPLII 207
Cdd:cd15960  94 RYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAMGWNclRAPASCSVLRPVTKNNAAVLAV-----SFLLLFAL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 208 MSVVYAKIFFATKRRLRErtrklgtlavpappqrtssrplaelesVASQedetepspepeplssradkpangisvHQFIE 287
Cdd:cd15960 169 MMQLYLQICRIAFRHAQQ---------------------------IAVQ--------------------------HQFVN 195
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12229835 288 EKQRISlskERKAARVLGVIMGVFVVCWLPfFLMYAIVpfctnCAPPSQRVVDFVTWL-GYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15960 196 FCLASS---TRKGVSTLSLILATFAFCWVP-FAVYSMV-----ADSSYPMIYTYYLVLpAACNSVINPIIYAFRNPDIQ 265
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-368 9.52e-12

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 64.97  E-value: 9.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQN---FFVVSLAVADLTVALFVLPLNVaYRLL---NQWLLGSYLCQ 106
Cdd:cd15130   1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQStvrYHLGSLALSDLLILLLAMPVEL-YNFIwvhHPWAFGDAGCR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 107 MWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL--LGWNDWPAQFTEDTP- 183
Cdd:cd15130  80 GYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLftMGLQNESDDGTHPGGl 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 184 -CTLTQER----LFVVYSSSGSFFIPLIIMSVVyakiffatkrrlrertrklgtlavpappqrtssrplaelesvasqed 258
Cdd:cd15130 160 vCTPIVDTatlkVVIQVNTFMSFLFPMLVTSIL----------------------------------------------- 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 259 etepspepeplssradkpaNGISVHQFIEEKQRislskerkAARVLGVIMGVFVVCWLPFF---LMYAIVPFCTNCAPps 335
Cdd:cd15130 193 -------------------NTVIANKLVQALRR--------GVLVLRAVVIAFVVCWLPYHvrrLMFCYISDEQWTTF-- 243
                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 12229835 336 qrVVDFVTW-------LGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15130 244 --LFDFYHYfymltnaLFYVSSAINPILYNLVSANFRQVF 281
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
36-229 1.34e-11

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 64.51  E-value: 1.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15183   4 PPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDL-VFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGW-NDWpaQFTEDTpC-------TLT 187
Cdd:cd15183  83 LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFkSQW--EFTHHT-CsahfprkSLI 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 12229835 188 QERLFVVYSSS-GSFFIPLIIMSVVYAKIFFATKRRLRERTRK 229
Cdd:cd15183 160 RWKRFQALKLNlLGLILPLLVMIICYTGIINILLRRPNEKKAK 202
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
37-368 1.53e-11

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 64.82  E-value: 1.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVT-IVGNSLVIISVFTYRPLRSVQNFF---VVSLAVADLTVALFVLPLNVAYRLLN--QWLLGSYLCQMWLT 110
Cdd:cd15135   4 TLLYSLILVAgILGNSATIKVTQVLQKKGYLQKSVtdhMVSLACSDLLVLLLGMPVELYSAIWDpfATPSGNIACKIYNF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 111 CDILCCTSSILNLCVIALDRYWAITDPINYAQKRTiRRVNTMIAAVWALSLVISVPPL----------------LGWNDW 174
Cdd:cd15135  84 LFEACSYATILNVATLSFERYIAICHPFKYKALSG-SRVRLLICFVWLTSALVALPLLfamgtedpleafpsyrGTRHHC 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 175 PAQFTEDTPCT-LTQERLFVVYSSSGSFFIPLIIMSVVyakIFFATKRRLRERTRKLGTLAVPAPPQRtssrplaelesv 253
Cdd:cd15135 163 QDQKSNLTICTsLSSKWTVFQASIFSAFVLYLLVLASV---AFMCRRMMRALMGSKKGAVAVKGPGGS------------ 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 254 asqedetepspepeplssradkpANGISVHQFIEEKqrislSKERKAARVLGVIMGVFVVCWLPF---FLMYAIVP---F 327
Cdd:cd15135 228 -----------------------VQLLRKHESAEGK-----TARKQTILFLGLIVGTLAVCWMPNqirRIMAAAKPkddW 279
                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 12229835 328 CTNCAPPSQRVVDFVTWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15135 280 TRSYFRAYIILLPIADTFFYLSSVLNPLLYNLSSQQFRSVF 320
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
39-221 1.60e-11

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 63.92  E-value: 1.60e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  39 LLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAyRLLNQWLLGSYLCQMWLTCDILCCTS 118
Cdd:cd15072   7 LLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASS-SLLRRWPYGSEGCQAHGFQGFFTALA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 119 SILNLCVIALDRYWAITDPINYAQKRTIrrvnTMIAAVWALSLVISVPPLLGWNDWPAQfTEDTPCTL---TQERLFVVY 195
Cdd:cd15072  86 SICSSAAIAWDRYHHYCTRSKLQWSTAI----SLVLFVWLFSAFWAAMPLLGWGEYDYE-PLGTCCTLdysKGDRNYVSY 160
                       170       180
                ....*....|....*....|....*....
gi 12229835 196 SSSGSFF---IPLIIMSVVYAKIFFATKR 221
Cdd:cd15072 161 LFTMAFFnfiLPLFILLTSYSSIEQKLKK 189
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
37-229 2.12e-11

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 63.99  E-value: 2.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAyRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15176   5 VFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPFWAA-DAVNGWVLGTAMCKITSALYTMNF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVntMIAAVWALSLVISVPPLL----GWND--------WPAQFTedTPC 184
Cdd:cd15176  83 SCGMQFLACISVDRYVAITKATSRQFTGKHCWI--VCLCVWLLAILLSIPDLVfstvRENSdryrclpvFPPSLV--TSA 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 12229835 185 TLTQERLFVVYsssgSFFIPLIIMSVVYAKIFFATKRRLRERTRK 229
Cdd:cd15176 159 KATIQILEVLL----GFVLPFLVMVFCYSRVARALSRTPNVKKSR 199
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
45-368 2.38e-11

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 63.80  E-value: 2.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  45 VTIVGNSLVIISVFT-YRPLRSVQNFFVVSLAVADLTVALFVLPLNVA-------YRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd14980  13 LALIGNILVIIWHISsKKKKKKVPKLLIINLAIADFLMGIYLLIIAIAdqyyrgrYAQYSEEWLRSPPCLLACFLVSLSS 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYaQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQ--FTEDTPCTL---TQERL 191
Cdd:cd14980  93 LMSVLMMLLITLDRYICIVYPFSN-KRLSYKSAKIILILGWLFSIIFAAIPILYSINQPGDnrLYGYSSICMpsnVSNPY 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSS--GSFFIPLIIMSVVYAKIFfatkrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepepl 269
Cdd:cd14980 172 YRGWLIAylLLTFIAWIIICILYILIF----------------------------------------------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 270 ssradkpangISVHQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqrVVDFVTWLGY-V 348
Cdd:cd14980 199 ----------ISVRKSRKSARRSSSKRDKRIAIRLALILITDLICWLPYYIVIFSGLLTSTEIDIH--VLQFIAILALpL 266
                       330       340
                ....*....|....*....|
gi 12229835 349 NSSLNPIIYTIYNKDFRTAF 368
Cdd:cd14980 267 NSAINPYLYTLTTPTFKRDF 286
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
50-368 2.50e-11

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 63.51  E-value: 2.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  50 NSLVIISVFTYRPLRSVQNFFVVSLAVADLTVAL-FVLPLNVAYRLLNQwllGSYLCQMWLTcdILCCTSSILNLCVIAL 128
Cdd:cd15961  18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIgLILNFIFAYLLQSE---AAKLVTVGLI--VASFSASVCSLLAITV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 129 DRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLFVVyssSGSFFIPLIIM 208
Cdd:cd15961  93 DRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLADESTCSVVRPLTKNNAAIL---SVSFLLMFALM 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 209 SVVYAKIFFATKRRLRErtrklgtlavpappqrtssrplaelesVASQedetepspepeplssradkpangisvHQFIEE 288
Cdd:cd15961 170 LQLYIQICKIVMRHAHQ---------------------------IALQ--------------------------HHFLAT 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 289 KQRISlskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTncaPPsqrVVDFVTWL-GYVNSSLNPIIYTIYNKDFRTA 367
Cdd:cd15961 197 SHYVT---TRKGVSTLAIILGTFAACWMPFTLYSLIADYTY---PS---IYTYATLLpATYNSIINPVIYAFRNQEIQKA 267

                .
gi 12229835 368 F 368
Cdd:cd15961 268 L 268
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
33-166 3.55e-11

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 63.30  E-value: 3.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILvTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAYRLLNQWLLGSYLCQMwltCD 112
Cdd:cd15121   2 LGIAILSLAFIL-GFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAV-LLTAPFFLHFLSGGGWEFGSVVCKL---CH 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835 113 ILCCTS---SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15121  77 YVCGVSmyaSIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLP 133
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
38-186 4.27e-11

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 63.35  E-value: 4.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIIL--VTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15126   4 LLLALVVfaVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYMEVTS 83
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12229835 116 CTSSILNLCVIALDRYWAITDPInyAQKRTIRRVNTMI---AAVWALSLVISVPPLLGWndwpaQFTEDTPCTL 186
Cdd:cd15126  84 LGVTTFSLCALGIDRFHAATSPQ--PKARPVERCQSILaklAVIWVGSMTLAVPELLLW-----QLAQETSPGS 150
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
33-168 4.63e-11

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 62.88  E-value: 4.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIIsVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLL-NQWLLGSYLCQMWLTC 111
Cdd:cd15120   1 VLIAVALFVTFLVGLVVNGLYLW-VLGFKMRRTVNTLWFLHLILSNL-IFTLILPFMAVHVLMdNHWAFGTVLCKVLNST 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL 168
Cdd:cd15120  79 LSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYL 135
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
38-232 4.98e-11

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 62.48  E-value: 4.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRS-VQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15219   5 LLVVVLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS-VPPLLGWNDWPAQFTEDTPCT--LTQERLFV 193
Cdd:cd15219  85 SNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSlVALFLSWLGYSSLYASCTLHLprEEERRRFA 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 12229835 194 VYSS---SGSFFIPLIIMSVVYAKIFfatKRRLRER-TRKLGT 232
Cdd:cd15219 165 VFTAffhAFTFLLSLLVLCVTYLKVL---KVRRRQRaTKKISI 204
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
44-222 5.32e-11

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 62.84  E-value: 5.32e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIIsVFTYRPLRSVQNFFVVSLAVADLTVALFvLPLNVAYRLLN-QWLLGSYLCQMWLTCDILCCTSSILN 122
Cdd:cd15119  12 VLGVPGNAIVIW-VTGFKWKKTVNTLWFLNLAIADFVFVLF-LPLHITYVALDfHWPFGVWLCKINSFVAVLNMFASVLF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 123 LCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL-------------LGWNDWpaqFTEDTPCTLTQE 189
Cdd:cd15119  90 LTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALyfrdtmelsinvtICFNNF---HKHDGDLIVMRH 166
                       170       180       190
                ....*....|....*....|....*....|...
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRR 222
Cdd:cd15119 167 TILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRR 199
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
37-368 5.58e-11

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 62.89  E-value: 5.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15082  18 ALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAVTFFG 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTiRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTeDTPC------TLTQER 190
Cdd:cd15082  98 IVALWSLAVLAFERFFVICRPLGNIRLQG-KHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKI-GTTCepnwysGNMHDH 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 LFVVYSSSGSFFIPLIIMSVVYAKIFfatkRRLRERTRKLGTLavpappqRTSSRPlaelesvasqedetepspepepls 270
Cdd:cd15082 176 TYIITFFTTCFILPLGVIFVSYGKLL----QKLRKVSNTQGRL-------GNARKP------------------------ 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpangisvhqfieekqrislskERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCApPSQRVVDFVTWLGYVNS 350
Cdd:cd15082 221 --------------------------ERQVTRMVVVMIVAFMVCWTPYAAFSILVTAHPTIH-LDPRLAAIPAFFSKTAA 273
                       330
                ....*....|....*...
gi 12229835 351 SLNPIIYTIYNKDFRTAF 368
Cdd:cd15082 274 VYNPIIYVFMNKQFRKCL 291
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
36-368 5.96e-11

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 62.53  E-value: 5.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADL------TVALFVLPLNVAYRLLNQWLL--GSYLCQM 107
Cdd:cd15345   4 TIFFLVICSFIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLlagiayKVNILMSGKKTFSLSPTQWFLreGSMFVAL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 108 wltcdilccTSSILNLCVIALDRYWAITDPINY-AQKRtiRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTL 186
Cdd:cd15345  84 ---------GASTFSLLAIAIERHLTMIKMRPYdANKR--YRVFLLIGTCWLISVLLGALPILGWNCLDNLPDCSTILPL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQERlFVVYSSSgSFFIPLIIMSVVYAKIFFATKRRLRERTRklgtlavpappQRTSSRPLAELESVAsqedetepspep 266
Cdd:cd15345 153 YSKK-YVAFCIS-IFIAILVAIVILYARIYILVKSSSRRVTN-----------HRNSERSMALLRTVV------------ 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangisvhqfieekqrislskerkaarvlgVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWLG 346
Cdd:cd15345 208 ---------------------------------------IVVGVFIACWSPLFILLLIDVACEVKQCPILYKADWFIALA 248
                       330       340
                ....*....|....*....|..
gi 12229835 347 YVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15345 249 VLNSAMNPIIYTLASKEMRRAF 270
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
37-169 6.58e-11

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 62.51  E-value: 6.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILV-TIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtvaLFVLPLNV-AYRLLNQWLLGSYLCQMWLTCDIL 114
Cdd:cd15187   4 PVLYCLLFVfGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDL---LFVFSLPFqAYYLLDQWVFGNAMCKIVSGAYYI 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 115 CCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL 169
Cdd:cd15187  81 GFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLV 135
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
41-235 7.55e-11

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 62.40  E-value: 7.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYrLLNQ--WLLGSYLCQ---MWLTCDILc 115
Cdd:cd15160   9 FVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYIL-TLPLWIDY-TANHhnWTFGPLSCKvvgFFFYTNIY- 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 ctSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLlgWNDWPAQFTED-TPC---------- 184
Cdd:cd15160  86 --ASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFL--GHDELFRDEPNhTLCyekypmegwq 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 185 -TLTQERLFVvysssgSFFIPLIIMSVVYAKIFFATKRR---LRERTRKLGTLAV 235
Cdd:cd15160 162 aSYNYARFLV------GFLIPLSLILFFYRRVLRAVRQSpslEREEKRKIIGLLL 210
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
37-215 9.20e-11

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 62.08  E-value: 9.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILC 115
Cdd:cd15191   5 VLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADL-LFLATLPLWATYYSYGyNWLFGSVMCKICGSLLTLN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINyAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLFVVY 195
Cdd:cd15191  84 LFASIFFITCMSVDRYLAVVYPLR-SQRRRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEELGVNACIMAFPNEKYAQ 162
                       170       180
                ....*....|....*....|....*...
gi 12229835 196 SSSG--------SFFIPLIIMSVVYAKI 215
Cdd:cd15191 163 WSAGlalmkntlGFLIPLIVIATCYFGI 190
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
37-215 1.12e-10

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 61.69  E-value: 1.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRLL-NQWLLGSYLCQmwLTCDILC 115
Cdd:cd15162   5 AVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVI-WLPFKIAYHIHgNNWIFGEALCR--LVTVAFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CT--SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPC-----TLTQ 188
Cdd:cd15162  82 GNmyCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITTChdvlpEQLL 161
                       170       180       190
                ....*....|....*....|....*....|
gi 12229835 189 ERLFVVYSSS---GSFFIPLIIMSVVYAKI 215
Cdd:cd15162 162 VGDWFYYFLSlaiVGFLIPFILTASCYVAT 191
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
33-368 1.57e-10

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 61.35  E-value: 1.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPL------NVAYRLLNQWLLGSYLCQ 106
Cdd:cd15342   1 YAVVALGLTVSVIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYLFLmfhtgpWTAKLSLYQWFLRQGLLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 107 MWLTcdilcctSSILNLCVIALDRYWAITDpINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTL 186
Cdd:cd15342  81 TSLT-------ASVANLLAIAVERHQTIFT-MQLHSKMSNQRVVILIFGIWMVALILGLIPAMGWNCLCDLKRCSTMAPL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQERLFVVYSSSGsfFIPLIIMSVVYAKIFFATKRRLRERTrklgtlavpappQRTSSRPLAElESVasqedetepspep 266
Cdd:cd15342 153 YSRSYLVFWALSN--LLTFLIMVAVYTRIFIYVRRKSQRMS------------EHHSSHPRYR-ETV------------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangisvhqfieekqrISLSKerkaarVLGVIMGVFVVCWLPFFLMYAIVPF-CTNCAPPSqrVVDFVTWL 345
Cdd:cd15342 205 -------------------------LGLMK------TVVIILGAFVVCWTPGQVVLLLDGLgCESCNVLA--YEKYFLLL 251
                       330       340
                ....*....|....*....|...
gi 12229835 346 GYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15342 252 AEINSLVNPIVYSYRDKEMRKTF 274
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
38-365 1.77e-10

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 60.96  E-value: 1.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLG---SYLCQMWLTCDIL 114
Cdd:cd15351   6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVcraPMLQHMDNVIDTM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTS---SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVppllgwndwpaqftedtpctltqerL 191
Cdd:cd15351  86 ICSSvvsSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSST-------------------------L 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSS--------GSFFIPLIIMSVVYAKIFFatkrRLRERTRKLGTLAVPAPPQRTSSRplaelesvasqedeteps 263
Cdd:cd15351 141 FIVYYNSnavilcliVFFLFMLVLMLVLYIHMFI----LACRHSQSISSQQRRQCPHQQTAS------------------ 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfieekqrislskeRKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVT 343
Cdd:cd15351 199 ----------------------------------LKGAITLTILLGIFFLCWGPFFLHLTLIVTCPTHPFCLCYFKYFNL 244
                       330       340
                ....*....|....*....|....
gi 12229835 344 WLGYV--NSSLNPIIYTIYNKDFR 365
Cdd:cd15351 245 FLILIicNSIIDPLIYAFRSQELR 268
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-172 2.01e-10

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 61.07  E-value: 2.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15977   4 TILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKAS 83
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITdpiNYAQKRTI---RRVNTMIAAVWALSLVISVPPLLGWN 172
Cdd:cd15977  84 VGITVLSLCALSIDRYRAVA---SWSRIRGIgipVWKAVEVTLIWAVAIIVAVPEAIAFD 140
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
38-361 2.64e-10

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 60.98  E-value: 2.64e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLL-NQWLLGSYLCQM--WLTCDIL 114
Cdd:cd15198   6 FLGVILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLgDRWMAGDVACRLlkLLQASAR 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSIlnLCVIALDRYWAITDPinyaQKRTIrRVNTMIAAVWALSLVISVPPLLGWN----DWPAQFTEDTPCTLT--- 187
Cdd:cd15198  86 GASANL--VVLLALDRHQAIRAP----LGQPL-RAWKLAALGWLLALLLALPQAYVFRvdfpDDPASAWPGHTLCRGifa 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 188 -----QERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRErtrklgtlavpAPPQRTSSRPLAELESVASQEDetep 262
Cdd:cd15198 159 plprwHLQVYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQ-----------APGAKKPWKKPSKSHLRATAPS---- 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvhqfieekqriSLSKER-KAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNcappSQRVVDF 341
Cdd:cd15198 224 ------------------------------ALPRAKvKTLKMTLVIALLFVGCSLPYFIAELAAAFGSG----DWEPEKV 269
                       330       340
                ....*....|....*....|...
gi 12229835 342 VTWLGYV---NSSLNPIIYTIYN 361
Cdd:cd15198 270 AAALGVMavaNSATNPFVFLFFN 292
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
33-235 3.50e-10

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 60.19  E-value: 3.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIiLVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAYRLLNQWLLGSYLCQmwlTCD 112
Cdd:cd14975   2 LGCTLLSLAF-AIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAV-LLTLPVWIYFLATGTWDFGLAACK---GCV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTS---SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLlgwndwPAQFTEDTP----CT 185
Cdd:cd14975  77 YVCAVSmyaSVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVI------AFRHVEETVengmCK 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 186 LT-----QERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLAV 235
Cdd:cd14975 151 YRhysdgQLVFHLLLETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTGRLIA 205
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
34-368 3.76e-10

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 60.28  E-value: 3.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLT-----VALFVLPLNVAYRLL-NQWLL--GSYLC 105
Cdd:cd15346   2 LTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayTANLLLSGATTYKLTpTQWFLreGSMFV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 106 QMwltcdilccTSSILNLCVIALDRYWAITDPINYAQKRTIRrVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCT 185
Cdd:cd15346  82 AL---------SASVFSLLAIAIERYITMLKMKLHNGSNSFR-SFLLISACWVISLILGGLPIMGWNCISALSSCSTVLP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 186 LTQERlFVVYSSSgSFFIPLIIMSVVYAKIFFAtkrrLRERTRKLGTLAVPAPPQRTSSRPLAELESVAsqedetepspe 265
Cdd:cd15346 152 LYHKH-YILFCTT-VFTLLLLSIVILYCRIYSL----VRTRSRRLTFRKNIRKASRSSEKSMALLKTVI----------- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 266 peplssradkpangisvhqfieekqrislskerkaarvlgVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVTWL 345
Cdd:cd15346 215 ----------------------------------------IVLSVFIACWAPLFILLLLDVGCKVKTCSILFKAEYFLVL 254
                       330       340
                ....*....|....*....|...
gi 12229835 346 GYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15346 255 AVLNSATNPIIYTLTNKEMRRAF 277
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
42-169 4.20e-10

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 59.78  E-value: 4.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtvaLFVLPLNV-AYRLLNQWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd15179  10 IFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADL---LFVLTLPFwAVDAAANWYFGNFLCKAVHVIYTVNLYSSV 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 12229835 121 LNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL 169
Cdd:cd15179  87 LILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLV 135
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
48-229 4.44e-10

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 59.77  E-value: 4.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  48 VGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtvaLFVLPLNV-AYRLLNQWLLGSYLCQMWLTCDILCCTSSILNLCVI 126
Cdd:cd15184  16 VGNMLVVLILINCKKLKSMTDIYLLNLAISDL---LFLLTLPFwAHYAANEWVFGNAMCKLLTGLYHIGFFSGIFFIILL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 127 ALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgwndwpaqFT----EDTPCTLTQERLFVVYSSSGSF- 201
Cdd:cd15184  93 TIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGII--------FTksqkEGSHYTCSPHFPPSQYQFWKNFq 164
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 12229835 202 ---------FIPLIIMSVVYAKIFFATKRRLRERTRK 229
Cdd:cd15184 165 tlkmnilglVLPLLVMIICYSGILKTLLRCRNEKKRH 201
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
36-366 5.11e-10

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 59.84  E-value: 5.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15077   4 SAFMLFLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAvWALSLVISVPPLLGWNDW----------PAQFTEDTPct 185
Cdd:cd15077  84 GMVSLWSLAVVAFERFLVICKPLGNFTFRGTHAIIGCIAT-WVFGLAASLPPLFGWSRYipeglqcscgPDWYTTNNK-- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 186 lTQERLFVVYSSSGSFFIPLIIMSVVYAKIffatkrrlrertrklgtlavpappqrtssrpLAELESVASQedetepspe 265
Cdd:cd15077 161 -WNNESYVMFLFCFCFGVPLSIIVFSYGRL-------------------------------LLTLRAVAKQ--------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 266 peplssradkpangisvhqfiEEKQRISLSKERKAARVLGVIMGVFVVCWLPfFLMYAIVPFCTNCAPPSQRVVDFVTWL 345
Cdd:cd15077 200 ---------------------QEQSASTQKAEREVTKMVVVMVLGFLVCWLP-YASFALWVVTNRGEPFDLRLASIPSVF 257
                       330       340
                ....*....|....*....|.
gi 12229835 346 GYVNSSLNPIIYTIYNKDFRT 366
Cdd:cd15077 258 SKASTVYNPVIYVFMNKQFRS 278
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
42-368 5.47e-10

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 60.05  E-value: 5.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNV-AYRLLNQWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd15218  10 IIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFtSVKNGSTWTYGTLTCKVIAFLGVLSCFHTA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 121 LNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWpAQFTEDTPCTLtQERLFVVYSSSGS 200
Cdd:cd15218  90 FMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTY-SFIREEDQCTF-QHRSFRANDSLGF 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 201 FFIPLIIM---SVVYAKIFFATKRRlreRTRKLGTLAVPAPPQRTSSRPLAELESVASQedetepspepEPLSSRADKPA 277
Cdd:cd15218 168 MLLLALILlatQLVYLKLIFFVHDR---RKMKPVQFVAAVSQNWTFHGPGASGQAAANW----------LAGFGRGPTPP 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 278 NGISVHQFIEEKQRISL------SKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFVtWLGYVNSS 351
Cdd:cd15218 235 TLLGIRQNANTTGRRRLlvldefKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVPGGFLTAAV-WMSFAQAG 313
                       330
                ....*....|....*..
gi 12229835 352 LNPIIYTIYNKDFRTAF 368
Cdd:cd15218 314 INPFVCIFSNRELRRCF 330
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
37-230 6.33e-10

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 59.32  E-value: 6.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLL-NQWLLGSYLCQMWLTCDILC 115
Cdd:cd15967   5 PVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADL-LYLLTLPFLVVYYLKgRKWIFGQVFCKITRFCFNLN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgwndWPAQFTEDTPC--TLTQERL-- 191
Cdd:cd15967  84 LYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLF----FSKTNSNGTKCfdTTFNDYLes 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 12229835 192 FVVYS---SSGSFFIPLIIMSVVYAKIFFATKRR------LRERTRKL 230
Cdd:cd15967 160 YLTYSlgwTVTGFVIPLLIILGCYGHVVVVLCRNnnvdkgLKQRCLKL 207
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
42-174 7.02e-10

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 59.15  E-value: 7.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVA--------YRLLNQWLLGSyLCQMWLTCDI 113
Cdd:cd15136  10 VFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVdaktlgeyYNYAIDWQTGA-GCKTAGFLAV 88
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDW 174
Cdd:cd15136  89 FSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSY 149
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
70-230 7.42e-10

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 59.39  E-value: 7.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  70 FVVSLAVADLTVALfVLPLNVAYRLL-NQWLLGSYLCQMWLT---CDILCctsSILNLCVIALDRYWAITDPINYAQKRT 145
Cdd:cd15369  38 YMLNLACADLLFVL-LLPFKIAYHFSgNDWLFGEAMCRVVTAafyCNMYC---SILLMTCISVDRFLAVVYPMQSLSWRT 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 146 IRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPC----TLTQERLFVVYS----SSGSFFIPLIIMSVVYAKIFF 217
Cdd:cd15369 114 LRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDLGITTChdvlNEQLLMGYYVYYfsifSCLFFFVPLIITTVCYVSIIR 193
                       170
                ....*....|....*...
gi 12229835 218 ATKR-----RLRERTRKL 230
Cdd:cd15369 194 CLSSssdvaNSSKKTRAL 211
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
36-166 8.92e-10

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 59.11  E-value: 8.92e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQ---NFFVVSLAVADLTVALFVLPLNVaYRLL---NQWLLGSYLCQMWL 109
Cdd:cd15356   4 TAVYALIWALGAAGNALTIHLVLKKRSLRGLQgtvHYHLVSLALSDLLILLISVPIEL-YNFVwfhYPWVFGDLVCRGYY 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835 110 TCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15356  83 FVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALP 139
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
36-166 1.36e-09

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 58.62  E-value: 1.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTY-RPLR--SVQNFFVVSLAVADLTVALfVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15154   1 TLHLVGYSLLFPVGLLLNAVALWVFvRYLRlhSVVSIYMCNLALSDLLFTL-SLPLRIYYYANHYWPFGNFLCQFSGSIF 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15154  80 QMNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVP 133
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
36-215 1.46e-09

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 58.25  E-value: 1.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAyRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15177   4 PCVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLL-LLTLPFAAA-ETLQGWIFGNAMCKLIQGLYAIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAI--TDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQftEDTPCTLTQERLFV 193
Cdd:cd15177  82 FYSGFLFLTCISVDRYVVIvrATSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRS--ELSSCRMIFPEVVS 159
                       170       180       190
                ....*....|....*....|....*....|
gi 12229835 194 VYSSSGS--------FFIPLIIMSVVYAKI 215
Cdd:cd15177 160 RTVKGATaltqvvlgFAIPLIVMAVCYAAI 189
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
37-365 1.71e-09

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 58.30  E-value: 1.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAII-LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15078   4 ALLIATIgFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITdpinYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWN-------------DWPAQFTEDT 182
Cdd:cd15078  84 GIVSIMTLTVLAYERYIRVV----HAKVVNFSWSWRAITYIWLYSLAWTGAPLLGWNrytlevhglgcsfDWKSKDPNDT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 183 PctltqerlFVVYSSSGSFFIPLIIMSVVYAKIFFATKRrlrertrklgtlavpappqrtssrplaeLESVasqedetep 262
Cdd:cd15078 160 S--------FVLLFFLGCLVVPLGIMAYCYGHILYEIRM----------------------------LRSV--------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 263 spepeplssradkpangisvhQFIEEKQRISLSK-ERKAARVLGVIMGVFVVCWLPFFLMYAIVPFC-TNCAPPSQRVVD 340
Cdd:cd15078 195 ---------------------EDLQTFQVIKILKyEKKVAKMCLLMISTFLICWMPYAVVSLLVTSGySKLVTPTIAIIP 253
                       330       340
                ....*....|....*....|....*
gi 12229835 341 FVtwLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15078 254 SL--FAKSSTAYNPVIYIFMIRKFR 276
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
42-215 1.80e-09

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 58.22  E-value: 1.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLP---LNVAYrllnQWLLGSYLCQMWLTCDILCCTS 118
Cdd:cd15174  10 IFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADL-LFLCTLPfwaTAASS----GWVFGTFLCKVVNSMYKINFYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 119 SILNLCVIALDRYWAI---TDPINYAQKRTIRRvNTMIAAVWALSLVISVPPLLGwndwpAQFTED---TPCTLtqerlf 192
Cdd:cd15174  85 CMLLLTCISVDRYIAIvqaTKAHNSKNKRLLYS-KLVCFFVWLLSTILSLPEILF-----SQSKEEesvTTCTM------ 152
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 12229835 193 vVYSSSGS---------------FFIPLIIMSVVYAKI 215
Cdd:cd15174 153 -VYPSNESnrfkvavlalkvtvgFFLPFVVMVICYTLI 189
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
36-365 2.00e-09

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 57.78  E-value: 2.00e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLnVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15180   4 PVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILL-LVTLPF-WAVQAVHGWIFGTGLCKLAGAVFKIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPL--LGWNDWPAQFTEDTPCTLTQERLFV 193
Cdd:cd15180  82 FYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFifLEATKDPRQNKTECVHNFPQSDTYW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 VYSSS-----GSFFIPLIIMSVVYAKIFfatkRRLRERTRKLgtlavpappqrtssrplaelesvasqedetepspepep 268
Cdd:cd15180 162 WLALRllyhiVGFLLPLAVMVYCYTSIL----LRLLRSSQGF-------------------------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 269 lssradkpangisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFL------MYAIVPFCTNCA-PPSQRVVDF 341
Cdd:cd15180 200 ---------------------------QKQRAIRVIVAVVVVFFLCWTPYNIallvdtLIDLSVLDRNCGtESRLDIALS 252
                       330       340
                ....*....|....*....|....*
gi 12229835 342 VT-WLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15180 253 VTsSLGYFHCCLNPLLYAFVGVKFR 277
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
34-169 2.37e-09

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 57.94  E-value: 2.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15127   2 AVMCLSVVIFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835 114 LCCTSSILNLCVIALDRYWAITD-PINYAQKRTIRRVNTMIAAVWALSLVISVPPLL 169
Cdd:cd15127  82 ASLGVTTFTLCALCIDRFRAATNvQMYYEMIENCTSTTAKLAVIWVGALLLALPEVV 138
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
38-215 2.53e-09

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 57.56  E-value: 2.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRL-LNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15194   6 LYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDF-IFLVTLPLWVDKEVvLGPWRSGSFLCKGSSYIISVNM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgwNDWPAQFTEDTPCT----LTQERLF 192
Cdd:cd15194  85 YCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLL--SRELKKYEEKEYCNedagTPSKVIF 162
                       170       180
                ....*....|....*....|...
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKI 215
Cdd:cd15194 163 SLVSLIVAFFLPLLSILTCYCTI 185
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
40-328 3.07e-09

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 57.10  E-value: 3.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLL---GSYLCQM-----WLTC 111
Cdd:cd15350   8 FTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLnrrGPFETKLddimdSLFC 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 112 diLCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgwndwpaqFTEDTPCTLTqerl 191
Cdd:cd15350  88 --LSLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGILMIL--------FFHFVATVIC---- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYsssgsFFIPLIIMSVVYAKIFFATkrrlRERTRKLGTLavpapPQRTSSRPLAELesvasqedetepspepeplss 271
Cdd:cd15350 154 FTVL-----FFLMLVLILCLYVHMFLLA----RSHARKIASL-----PNHHAQHQRSNM--------------------- 198
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835 272 radkpangisvhqfieekqrislskerKAARVLGVIMGVFVVCWLPFFLMYAIVPFC 328
Cdd:cd15350 199 ---------------------------RGAITLTILLGVFVCCWAPFVLHLLLMMFC 228
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
39-366 4.55e-09

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 57.08  E-value: 4.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  39 LLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15381   7 LWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVC-CLPFWAINISNGfNWPFGEFLCKSVNAVIYMNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTqerlfvvYSS 197
Cdd:cd15381  86 SSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITACVLD-------YPS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 198 SGSFFIPLIIMSVVYAKIffatkrrlrertrklgtlavpappqrtssrPLAELESVASQEdetepspepeplssradkpa 277
Cdd:cd15381 159 EGWHVALNILLNVVGFLI------------------------------PLSIITFCSTQI-------------------- 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 278 ngISVHQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPF----FL----MYAIVPFCTNcappsQRVVDFV----TWL 345
Cdd:cd15381 189 --IQVLRNNKMQKFKEIQTERKATVLVLAVLLMFFICWLPFhiftFLdtlhKLGLISGCRW-----EDILDIGtqiaTFL 261
                       330       340
                ....*....|....*....|.
gi 12229835 346 GYVNSSLNPIIYTIYNKDFRT 366
Cdd:cd15381 262 AYSNSCLNPLLYVIVGKHFRK 282
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
42-166 4.66e-09

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 56.76  E-value: 4.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15185  10 VFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDL-LFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSEIF 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15185  89 FIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALP 133
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
34-367 4.72e-09

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 56.72  E-value: 4.72e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVAlfvlplnVAYrLLNQWLLGSYLCQM----WL 109
Cdd:cd15349   2 ALTVLFICISVLIILENLLVLLAILRRVRLRRWVYICLANIALSDLLTG-------TSY-LVNICLSGERTFRLtpalWF 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 110 TCDILCCTS---SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpaqftedtpCTL 186
Cdd:cd15349  74 LREGLLFTAlaaSTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGWN-----------CLC 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQER---LFVVYSSSGSFFIpLIIMSVVYAKI---FFATKRRLRERTRKlgtlavpAPPQRTSSRPLAELESVASqedet 260
Cdd:cd15349 143 DFRScssLLPLYSKSYILFC-LVIFFIILLTIiglYFAIYCLVRASGQR-------VISARSRRRSLRLLKTVLM----- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 261 epspepeplssradkpangisvhqfieekqrislskerkaarvlgvIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVD 340
Cdd:cd15349 210 ----------------------------------------------ILGAFMVCWGPLFILLLVDFFCSSRSCKPLFGME 243
                       330       340
                ....*....|....*....|....*..
gi 12229835 341 FVTWLGYVNSSLNPIIYTIYNKDFRTA 367
Cdd:cd15349 244 WVLALAVLNSAINPLIYSFRSLEVRRA 270
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
42-166 5.62e-09

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 56.70  E-value: 5.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMwltCDILCCTS--- 118
Cdd:cd15398  10 ISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHI---VPFLQCVSvmv 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 12229835 119 SILNLCVIALDRYWAITDPInyAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15398  87 STLMLMSIAIVRYHMIKHPL--SNHLTANHGYFLLGTVWTLGFTICSP 132
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
44-366 6.65e-09

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 56.40  E-value: 6.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNL 123
Cdd:cd15085  12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 124 CVIALDRYWAITDPINyAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEdTPCTLT-QERLFVVYS-----S 197
Cdd:cd15085  92 TLLAYERYNVVCKPMG-GLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGVQ-TSCSIGwEERSWSNYSylilyF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 198 SGSFFIPLIIMSVVYAKIFfatkRRLRERTRKLGTLAVPAPPQrtssrplaelesvasqedetepspepeplssradkpa 277
Cdd:cd15085 170 LMCFVIPVAIIGFSYGNVL----RSLHKLNKKIEQQGGKNCPE------------------------------------- 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 278 ngisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSqRVVDFVTWLGYVNSSLNPIIY 357
Cdd:cd15085 209 ------------------EEERAVIMVLAMVIAFLICWLPYTVFALIVVVNPELSISP-LAATMPTYFAKTSPVYNPIIY 269

                ....*....
gi 12229835 358 TIYNKDFRT 366
Cdd:cd15085 270 IFLNKQFRE 278
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
33-208 7.53e-09

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 56.00  E-value: 7.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15404   1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAItdpINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDwpAQFTEDTP------CTL 186
Cdd:cd15404  81 WLFVMEGVAILLIISIDRFLII---VQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPD--LQIPSRAPqcvfgyTTN 155
                       170       180
                ....*....|....*....|..
gi 12229835 187 TQERLFVVYSSSGSFFIPLIIM 208
Cdd:cd15404 156 PGYQAYVILIMLIFFFIPFMVM 177
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
33-368 8.27e-09

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 55.98  E-value: 8.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADL--TVALFVLPLN---VAYRL-LNQWLLGSYLCQ 106
Cdd:cd15101   1 VLVMGLGITVCIFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFfaGLAYFFLMFNtgpNTRRLtVSTWFLRQGLLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 107 MWLTcdilcctSSILNLCVIALDRYWAITDpINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTL 186
Cdd:cd15101  81 TSLT-------ASVANLLAIAVERHISVMR-MQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGWNCLCAIDACSNMAPL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 TQERLFVVYSSSGsfFIPLIIMSVVYAKIFFATKRrlreRTRKLGTLAVPAPPQRTSsrPLAELESVAsqedetepspep 266
Cdd:cd15101 153 YSRSYLVFWAISN--LVTFLVMVVVYARIFVYVRR----RTNRMSPHTSGSIRNRDT--MMSLLKTVV------------ 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 eplssradkpangisvhqfieekqrislskerkaarvlgVIMGVFVVCWLP-FFLMYAIVPFCTNCAppSQRVVDFVTWL 345
Cdd:cd15101 213 ---------------------------------------IVLGAFVVCWTPgLVVLLLDGLCCRQCN--VLAVEKFFLLL 251
                       330       340
                ....*....|....*....|...
gi 12229835 346 GYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15101 252 AEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
50-363 8.43e-09

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 56.04  E-value: 8.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  50 NSLVIISVFTYRPLRSVQNFFVVSLAVADLTVAL-----FVLPLNVAYRLLNQWLLGSYLCQMwltcdilccTSSILNLC 124
Cdd:cd15963  18 NAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLglilhFAFVYCIQSAPVNLVTVGLLAPSF---------TASVSSLL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 125 VIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLFVVyssSGSFFIP 204
Cdd:cd15963  89 AITIDRYLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPVVGWNCLKDPSTCSVVKPLTKNHLVIL---SISFFMV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 205 LIIMSVVYAKIFFATKRRLRERTRKLGTLAVPappqrtssrplaelESVASqedetepspepeplssradkpangisvhq 284
Cdd:cd15963 166 FALMLQLYAQICRIVCRHAHQIALQRHFLPTS--------------HYVTT----------------------------- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 285 fieekqrislskeRKAARVLGVIMGVFVVCWLPFFLmyaivpFCTNCAPPSQRVVDFVTWL-GYVNSSLNPIIYTIYNKD 363
Cdd:cd15963 203 -------------RKGIATLAVILGTFASCWLPFAV------YCLLGDYTYPALYTYATLLpATYNSMINPIIYAFRNQE 263
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
33-166 8.55e-09

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 55.94  E-value: 8.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAYRLLNQ-WLLGSYLCQMWLTC 111
Cdd:cd14988   1 VVLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGV-VLTLPVWMLEVMLDYtWLWGSFLCKFTHYF 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd14988  80 YFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLP 134
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
38-174 1.06e-08

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 55.53  E-value: 1.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLT--VALFVLPlnvayRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15905   4 LSVPLSSLIIFANLFIILGIACNRKLHNTANYFFLSLLLADLLtgVALPFIP-----GMSNESRRGYHSCLFVYVAPNFL 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDW 174
Cdd:cd15905  79 FLSFLANLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLPALGWNNW 137
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
35-175 1.15e-08

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 55.68  E-value: 1.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDIL 114
Cdd:cd15081  15 TSVWMIFVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSV 94
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 115 CCTSSILNLCVIALDRYWAITDP---INYAQKRTIrrvnTMIAAVWALSLVISVPPLLGWND-WP 175
Cdd:cd15081  95 CGITGLWSLTIISWERWVVVCKPfgnIKFDGKLAI----VGIIFSWVWSAVWCAPPIFGWSRyWP 155
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
70-233 1.61e-08

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 55.17  E-value: 1.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  70 FVVSLAVADLTVALfVLPLNVAYRL-LNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRR 148
Cdd:cd15365  38 YLFNLSLSDLLYIV-ILPLWIDYLWnGDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRT 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 149 VNTMIAAVWALSlVISVPPLLGWNDWPAQFTEDTPC------TLTQERLFVVYSSSGsFFIPLIIMSVVYAKIFF----- 217
Cdd:cd15365 117 ALSVSVAIWLLE-ICFNAVILTWEDSFHESSSHTLCydkfplEDWQARLNLFRICLG-YLLPLLIILFCYWKIYQavrsn 194
                       170
                ....*....|....*..
gi 12229835 218 -ATKRRLRERTRKLGTL 233
Cdd:cd15365 195 qATEDQEKKKIFKLLLL 211
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-172 2.17e-08

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 54.86  E-value: 2.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15976   4 TVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKAS 83
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITdpiNYAQKRTI---RRVNTMIAAVWALSLVISVPPLLGWN 172
Cdd:cd15976  84 VGITVLSLCALSIDRYRAVA---SWSRIKGIgvpKWTAVEIVLIWVVSIILAVPEAIGFD 140
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
36-182 3.74e-08

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 54.10  E-value: 3.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLL-----GSYLCQMWLT 110
Cdd:cd15975   4 TVLSCIIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFddssfGVFLCKLVPF 83
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12229835 111 CDILCCTSSILNLCVIALDRYWAITDpINYAQKRTIRRVNTM-IAAVWALSLVISVPPLLGWNDWPAQFTEDT 182
Cdd:cd15975  84 LQKASVGITVLNLCALSVDRYRAVAS-WSRVQGIGIPLITAIeIFSIWVLSFILAIPEAIGFVMVPFEYNGEQ 155
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
38-365 4.02e-08

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 53.99  E-value: 4.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAYRLLNQ-WLLGSYLCQMWLTCDILCC 116
Cdd:cd14991   6 LLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLL-LICLPFRIDYYLRGEhWIFGEAWCRVNLFMLSVNR 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDP---INYAQKRTIRRVNTMIaavWALSLVISVPPLLgwNDWPAQFTEDTPCtltqeRLFV 193
Cdd:cd14991  85 SASIAFLTAVALDRYFKVVHPhhrVNRMSVKAAAGVAGLL---WALVLLLTLPLLL--STLLTVNSNKSSC-----HSFS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 194 VYSSS------------GSFFIPLIIMSVVYAKIFFATKRRlrertrklgtlavpappqrtssrplaelesvasqedete 261
Cdd:cd14991 155 SYTKPslsirwhnalflLEFFLPLGLIVFCSVRIACNLRIR--------------------------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 262 pspepeplssradkpangisvhQFIEEKQRIslskeRKAARVLGVIMGVFVVCWLP-----FFLMYAIVPFCTNCAPPSQ 336
Cdd:cd14991 196 ----------------------QSLGKQARV-----QRAIRLVFLVVIVFVLCFLPsiiagLLALVFKNLGSCRCLNSVA 248
                       330       340
                ....*....|....*....|....*....
gi 12229835 337 RVVDFVTWLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd14991 249 QLFHISLAFTYLNSALDPVIYCFSSPWFR 277
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-212 4.47e-08

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 54.06  E-value: 4.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQW-----LLGSYLCQMWLT 110
Cdd:cd15128   4 TVVSCLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWpfgdqPFGQFLCKLVPF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 111 CDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDT--PCTLTQ 188
Cdd:cd15128  84 IQKASVGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFNYKGVTlrTCLLRP 163
                       170       180       190
                ....*....|....*....|....*....|..
gi 12229835 189 ERLFVVYSSSGS--------FFIPLIIMSVVY 212
Cdd:cd15128 164 ETSFMKFYIDVKdwwlfgfyFCLPLVCTAIFY 195
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
70-168 5.93e-08

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 53.60  E-value: 5.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  70 FVVSLAVADLtvaLFVLPLN---VAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTI 146
Cdd:cd15147  40 FMVNLTIADL---LFLITLPfwiVYYHNEGNWILPKFLCNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTR 116
                        90       100
                ....*....|....*....|..
gi 12229835 147 RRVNTMIAAVWALSLVISVPPL 168
Cdd:cd15147 117 KRGIIISVAIWVIIVASASYFL 138
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
35-364 6.35e-08

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 53.27  E-value: 6.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAY-RLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15118   2 ATICLHGIVSTLGIVENLLILWVVGFRLRRTVISIWILNLALSDLLATL-SLPFFTYYlASGHTWELGTTFCRIHSSIFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP-------------PLLGWNDW----PA 176
Cdd:cd15118  81 LNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPyfvfrdvierkdgRKLCYYNFalfsPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 177 QFTEDTPCTLTQERlFVVYSSSGSFFIPLIIMSVVYAKIffatKRRLRERTRKlgtlavpappqrtssrplaelesvasq 256
Cdd:cd15118 161 PDNNHPICKQRQEG-LAISKLLLAFLIPLVIIAVSYAVV----SLIIRHRCRR--------------------------- 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 257 edetepspepeplssradkpangisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLP---FFLMYAIVPFCTNCAP 333
Cdd:cd15118 209 ---------------------------------------RPGRFVRLVVSVVVSFALCWAPyhiFSIIEVMAHNQHSLRP 249
                       330       340       350
                ....*....|....*....|....*....|.
gi 12229835 334 PSQRVVDFVTWLGYVNSSLNPIIYTIYNKDF 364
Cdd:cd15118 250 LVIQGLPFATTLAFLNSVLNPVLYVFSCPDF 280
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
34-366 7.28e-08

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 53.30  E-value: 7.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  34 AATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDI 113
Cdd:cd15080   2 ALAAYMFLLILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFAT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 114 LCCTSSILNLCVIALDRYWAITDPIN---YAQKRTIRRVntmiAAVWALSLVISVPPLLGWNDWpaqFTEDTPC------ 184
Cdd:cd15080  82 LGGEIALWSLVVLAIERYVVVCKPMSnfrFGENHAIMGV----AFTWVMALACAAPPLVGWSRY---IPEGMQCscgidy 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 185 -TLTQE---RLFVVYSSSGSFFIPLIIMSVVYAKIFFATKrrlrertrklgtlavpappqrtssrplaelESVASQEDEt 260
Cdd:cd15080 155 yTLKPEvnnESFVIYMFVVHFTIPLIVIFFCYGRLVCTVK------------------------------EAAAQQQES- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 261 epspepeplssradkpangisvhqfiEEKQRislsKERKAARVLGVIMGVFVVCWLPfflmYAIVPFCTNCAPPSQRVVD 340
Cdd:cd15080 204 --------------------------ATTQK----AEKEVTRMVIIMVIAFLICWVP----YASVAFYIFTHQGSDFGPI 249
                       330       340
                ....*....|....*....|....*....
gi 12229835 341 FVTWLGYVNSS---LNPIIYTIYNKDFRT 366
Cdd:cd15080 250 FMTIPAFFAKSsavYNPVIYILMNKQFRN 278
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
33-166 7.34e-08

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 53.16  E-value: 7.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLL-NQWLLGSYLCQMWLTC 111
Cdd:cd15148   1 LPLAVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADL-LLIICLPFRILYHVNnNQWTLGPLLCKVVGNL 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPInyAQKRTIRRVNTMIAA--VWALSLVISVP 166
Cdd:cd15148  80 FYMNMYISIILLGFISLDRYLKINRSS--RRQKFLTRKWSIVACgvLWAVALVGFVP 134
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
44-363 8.14e-08

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 52.96  E-value: 8.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADL--TVALFVLPLN---VAYRL-LNQWLLGSYLCQMWLTcdilcct 117
Cdd:cd15343  12 LFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFfaGIAYVFLMFNtgpVSKTLtVNRWFLRQGLLDTSLS------- 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDpINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwpaqftedTPCTLTQ-ERLFVVYS 196
Cdd:cd15343  85 ASLTNLLVIAVERHISIMR-MKVHSNLTKRRVTLLIALVWAIAIFMGAVPTLGWN---------CICNISAcSSLAPIYS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 197 SSGSFF------IPLIIMSVVYAKIFFATKRRlrertrklgtlavpappqrtssrplaelesvasqedetepspepepls 270
Cdd:cd15343 155 RSYLVFwsvsnlVVFLIMVVVYLRIYVYVQRK------------------------------------------------ 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpANGISVHqfieekQRISLSKERKAARVLGVIM---GVFVVCWLPFFLMYAIVPF-CTNCAppSQRVVDFVTWLG 346
Cdd:cd15343 187 ------TNVLSPH------TSGSINRRRTPIKLMKTVMtvlGAFVICWTPGLVVLLLDGLnCTRCG--VQHVKRWFLLLA 252
                       330
                ....*....|....*..
gi 12229835 347 YVNSSLNPIIYTIYNKD 363
Cdd:cd15343 253 LLNSVMNPIIYSYKDEE 269
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
43-184 9.24e-08

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 52.83  E-value: 9.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  43 ILVTIVG--NSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRLL-NQWLLGSYLCQM---WLTCDILCc 116
Cdd:cd15372   8 TLVFLVGlpANGLALWVLATQVKRLPSTIFLINLAVADLLLIL-VLPFKISYHFLgNNWPFGEGLCRVvtaFFYGNMYC- 85
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12229835 117 tsSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPC 184
Cdd:cd15372  86 --SVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLC 151
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
57-161 9.95e-08

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 53.00  E-value: 9.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  57 VFTYR-PLRSVQNFFVVSLAVADLtVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAIT 135
Cdd:cd15155  24 VFCFRmKMRNETAIFMTNLAVSDL-LFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIV 102
                        90       100
                ....*....|....*....|....*.
gi 12229835 136 DPINYAQKRTIRRVNTMIAAVWALSL 161
Cdd:cd15155 103 YPFRSRTIRTRRNSAIVCAGVWILVL 128
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
35-367 1.33e-07

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 52.53  E-value: 1.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAII-LVTIVGNSLVIISVFTYRPLRSVQNF-FVVSLAVADLTVALFVLPLNVAYRLLNQwLLGSYLCQMWLTCD 112
Cdd:cd15341   2 AIAVLCTLCgLLCILENVAVLYLILSSPKLRRKPSYlFIGSLALADFLASVVFACSFVDFHVFHG-VDSSAIFLLKLGGV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAqfteDTPCTLTQERLF 192
Cdd:cd15341  81 TMSFTASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLMGWNCCPL----NSPCSELFPLIP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIFFATKrrlrertrklgtlavpappqrtssrplaelesvasqedetepspepeplssr 272
Cdd:cd15341 157 NDYLLSWLLLVAILLSGIIYTYGHVLWK---------------------------------------------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 273 ADKPANGISVHQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPF--FLMYAIVpfcTNCAPPSQRVVDFVTWLGYVNS 350
Cdd:cd15341 185 AHKHVVYMEKHQDQQGPGNARMRLDVRLAKTLGLVLAVLLICWSPVlaLMMHSLF---TSLSDHIKKAFAFCSTLCLVNS 261
                       330
                ....*....|....*..
gi 12229835 351 SLNPIIYTIYNKDFRTA 367
Cdd:cd15341 262 MVNPIIYALRSRELRSS 278
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
40-215 1.68e-07

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 52.12  E-value: 1.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVI-ISVFTYRPLRSVqNFFVVSLAVADLtvaLFV--LPLNVAYRLLN-QWLLGSYLCQMWLTCDILC 115
Cdd:cd15921   8 ILIFILGLTGNSISVyVFLSQYRSQTPV-SVLMVNLAISDL---LLVctLPLRLTYYVLNsHWPFGDIACRIILYVLYVN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDW----------PAQFTEDTPCT 185
Cdd:cd15921  84 MYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQhdegstrcleLAHDAVDKLLL 163
                       170       180       190
                ....*....|....*....|....*....|
gi 12229835 186 LTQERLFVvysssgSFFIPLIIMSVVYAKI 215
Cdd:cd15921 164 INYVTLPV------GFVVPFMTVIFCYIFI 187
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
40-170 1.73e-07

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 52.02  E-value: 1.73e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVF-TYRPLRSVqNFFVVSLAVADLtvaLFV--LPLNVAYRLLN-QWLLGSYLCQMWLTCDILC 115
Cdd:cd15157   8 LIIFVLGVVGNGLSIYVFLqPSKKKTSV-NIFMLNLAVSDL---MFVstLPFRADYYLMGsHWVFGDIACRIMSYSLYVN 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLG 170
Cdd:cd15157  84 MYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLLSK 138
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
37-225 1.74e-07

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 51.93  E-value: 1.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVI-ISVFTYRPLRSVqNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQM---WLTCD 112
Cdd:cd15168   5 IVYGVVFLVGLLLNSVVLyRFIFHLKPWNSS-AIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLvrfLFYFN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCctsSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNdwPAQFTEDTPC-TLTQERL 191
Cdd:cd15168  84 LYG---SILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFAT--TGRKNNRTTCyDTTSPEE 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGS------FFIPLIIMSVVYAKIFFATKRRLRE 225
Cdd:cd15168 159 LNDYVIYSMvltglgFLLPLLIILACYGLIVRALIRKLGE 198
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
42-169 2.24e-07

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 51.71  E-value: 2.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRP-LRSVQNFFVVSLAVADLtvaLFVLPLNV-AYRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15188  10 VFLLGLAGNLLLFVVLLLYVPkKKKMTEVYLLNLAVSDL---LFLVTLPFwAMYVAWHWVFGSFLCKFVSTLYTINFYSG 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL 169
Cdd:cd15188  87 IFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMV 136
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
45-367 2.44e-07

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 51.80  E-value: 2.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  45 VTIVGNSLV--IISVFTYRPLRSVqNFFVVSLAVADLTVALfVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15925  13 IGLLGNLAVmyLLRNCARRAPPPI-DVFVFNLALADFGFAL-TLPFWAVESALDfHWPFGGAMCKMVLTATVLNVYASVF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQERLFVVYSSSG-- 199
Cdd:cd15925  91 LLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKFPSNYWLGAYHLQRvv 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 200 -SFFIPLIIMSVVYAKIF-FATKRRLRERTRKlgtlavpappqrtssrplaelesvasqedetepspepeplssradkpa 277
Cdd:cd15925 171 vAFVVPLGVITTSYLLLLsFLQQHKVNQNNRQ------------------------------------------------ 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 278 ngisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLP--------FFLMYAIVPFCTNCAPPSQRVVDFVTWLGYVN 349
Cdd:cd15925 203 ------------------RQSVIARSVRLVVASFFLCWFPnhvvtfwgVLVKFRAVPWNSTFYFIHTYVFPVTTCLAHSN 264
                       330
                ....*....|....*...
gi 12229835 350 SSLNPIIYTIYNKDFRTA 367
Cdd:cd15925 265 SCLNPVLYCLMRREFRQA 282
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
41-230 2.53e-07

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 51.61  E-value: 2.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVI-ISVFTYRPLRSvQNFFVVSLAVADLtvaLFV--LPLNVAYRLL-NQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15375   9 IIFIVGFPGNIIAIfVYLFKMRPWKS-STIIMLNLALTDL---LYVtsLPFLIYYYINgESWIFGEFMCKFIRFIFHFNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQ-------FTEDTPctLTQE 189
Cdd:cd15375  85 YGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNnrticldFTSSDN--LNTI 162
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 12229835 190 RLFVVYSSSGSFFIPLIIMSVVYAKIFFATKR------RLRERTRKL 230
Cdd:cd15375 163 WWYNWILTVLGFLLPLVIVTLCYTRIIYTLAKgphtgsASKQKARRL 209
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
63-222 4.25e-07

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 51.01  E-value: 4.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  63 LRSVQNFFVVSLAVADLtVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQ 142
Cdd:cd15156  31 VRNETTTYMINLAISDL-LFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYGSILFLTCISVDRFLAIVYPFRSKT 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 143 KRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCT--------LTQERLFVVYSSSGSFFIPLiIMSVVYAK 214
Cdd:cd15156 110 LRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSETCFenfssktwKTYLSKIVIFIEIVGFFIPL-ILNVTCST 188

                ....*...
gi 12229835 215 IFFATKRR 222
Cdd:cd15156 189 MVLKTLRR 196
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
38-170 6.87e-07

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 50.30  E-value: 6.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15431   6 LLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGI 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLG 170
Cdd:cd15431  86 TECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLT 138
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
37-164 8.26e-07

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 49.91  E-value: 8.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlnvayRLLNQWLLG----SY---LCQMWL 109
Cdd:cd15235   6 LLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVP-----KMLANLLSGsktiSYagcLAQMYF 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 110 TCdILCCTSSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS 164
Cdd:cd15235  81 FI-AFGNTDSFL-LAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHS 133
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
38-165 1.02e-06

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 49.79  E-value: 1.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWL-TCDILCC 116
Cdd:cd15428   6 LFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLyFFLSFGI 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 12229835 117 TSSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISV 165
Cdd:cd15428  86 TECAL-LSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSA 133
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
37-222 1.32e-06

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 49.38  E-value: 1.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAI-ILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVaLFVLPLNVAYRLLNQ-WLLGSYLCQMWLTCDIL 114
Cdd:cd15200   4 APVLGIeFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFL-IINLPFRIDYYLRNEvWRFGATACQVNLFMLSM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLG--WNDWPAQFTEDTPCTLT----- 187
Cdd:cd15200  83 NRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLdhVQSNSTCLSYDHGTDPSasdrw 162
                       170       180       190
                ....*....|....*....|....*....|....*
gi 12229835 188 QERLFVVysssgSFFIPLIIMSVVYAKIFFATKRR 222
Cdd:cd15200 163 HRILFFL-----EFFLPLGIILFCIFSIILTLKQR 192
7tmA_SREB1_GPR27 cd15216
super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...
37-368 1.45e-06

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320344 [Multi-domain]  Cd Length: 332  Bit Score: 49.64  E-value: 1.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLP-LNVAYRLLNQWL---LGSYLCQMWLTCD 112
Cdd:cd15216   5 ATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPaVMLAARRAAAAAgtpPGALGCKLLAFLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTM-IAAVWALSLVISVPPLLgwnDWPAQFTEDTPCTLTQeRL 191
Cdd:cd15216  85 ALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMlVCAAWALALAAAFPPVL---DGGGADDEDAPCALEQ-RP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGSFFIPLIIMS---VVYAKIFFATKRRLRERTRKLgtlaVPAPPQR-TSSRPLAELESVAS-QEDETEPSPEP 266
Cdd:cd15216 161 DGAPGALGFLLLLAAVVGathLVYLRLLFFIHDRRKMRPARL----VPAVSHDwTFHGPGATGQAAANwTAGFGRGPTPP 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 267 EPLSSRADKPANGISVHQFIEEkqrisLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPsQRVVDFVTWLG 346
Cdd:cd15216 237 ALVGIRPAGPGRGARRLLVLEE-----FKTEKRLCKMFYAITLLFLLLWGPYVVASYLRVLVRPGAVP-QAYLTASVWLT 310
                       330       340
                ....*....|....*....|..
gi 12229835 347 YVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15216 311 FAQAGINPVVCFLFNRELRDCF 332
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
70-230 1.74e-06

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 49.02  E-value: 1.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  70 FVVSLAVADLtVALFVLPLNVAYRL-LNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRR 148
Cdd:cd15366  38 YLLNLSVSDL-LYIATLPLWIDYFLhRDNWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKT 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 149 VNTMIAAVWALSLVISVPPLLGWNDWPAQFTEdtpcTLTQER--------LFVVYSSSGSFFIPLIIMSVVYAKIFFA-- 218
Cdd:cd15366 117 AVAVSAVVWAIEIGANSAPLFHDELFRDRYNH----TFCFEKypmedwvaWMNLYRVFVGFLFPWVLMLFSYRGILRAvr 192
                       170
                ....*....|....*.
gi 12229835 219 ----TKRRLRERTRKL 230
Cdd:cd15366 193 gnvsTEQQEKAKIKRL 208
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
44-254 1.77e-06

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 49.04  E-value: 1.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFF--VVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQmWLTCDILCCTSSIL 121
Cdd:cd15142  12 IFGVVGNLIAIVVLCKSRKEQKETTFYtlVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCE-YFSFILLFFSLSGL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 N-LCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTeDTPCTL---TQERLFVVYSS 197
Cdd:cd15142  91 SiICAMSIERYLAINHAYFYNHYVDKRLAGLTLFAIYASNILFCALPSMGLGKSKLQYP-KTWCFIdwrTNVSVHAAYSY 169
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 198 SGSFFIPLIIMSVVYAKI-----FFATKRRLRERTrKLGTLAVPAPPQRTSSRPL---AELESVA 254
Cdd:cd15142 170 MYAGFSSLLILVTVLCNVlvcgaLIRMHRQFVRRT-SLGTDQRLSDFRRRRSFRRmagAEIQMVI 233
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
37-165 1.95e-06

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 48.81  E-value: 1.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLC--QMWLTcdiL 114
Cdd:cd15237   5 ILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCaaQMFFF---L 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 12229835 115 CC-TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISV 165
Cdd:cd15237  82 ALgVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSL 133
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
70-368 2.11e-06

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 48.80  E-value: 2.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  70 FVVSLAVADLTVaLFVLPLnVAYRLLNQW--------LLGSYLCQMWLtcdilcctsSILNLCVIALDRYWAITDPINYA 141
Cdd:cd15164  38 YMINLAVADCCL-LFSLPF-VLYFLKHSWpddelclvLQSIYFINRYM---------SIYIITAIAVDRYIAIKYPLKAK 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 142 QKRTIRRVNTMIAAVWALsLVISVPPLLGWndwpaQFTEDTPC---TLTQERLFVVYSSSGSFFIPLIIMSvvyakifFA 218
Cdd:cd15164 107 SLRSPRKAALTCGLLWVL-VIISVSLRLAW-----EEQEENFCfgkTSTRPSKRTLIFSLLGFFIPLIILS-------FC 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 219 TKRRLRERTRKLGTlavpappqrtssrplaelesvasqedetepspepeplssradkpangisvhQFIEEKQRislskeR 298
Cdd:cd15164 174 SIQVIRSLKKKKKT---------------------------------------------------NPHEEKLI------Q 196
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835 299 KAARVLGVIMGVFVVCWLPF----FLMYAIVPFCTNCaPPSQRVVDFV---TWLGYVNSSLNPIIYTIYNKDFRTAF 368
Cdd:cd15164 197 KAIYIVSANLIVFIVCFLPLhiglLVRFVMESNKASC-SLIQNIRNFIyvaSCLANANCCLDAICYYFVAKEFQEAS 272
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
38-164 2.51e-06

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 48.41  E-value: 2.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlnvayRLLNQWLLG----SY---LCQMWLT 110
Cdd:cd15232   6 LFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVP-----KLLQNLLTErktiSFggcMAQLYFF 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 12229835 111 cdILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS 164
Cdd:cd15232  81 --TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNS 132
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
36-166 2.64e-06

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 48.72  E-value: 2.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAyrllnqwLLGSYLCQMWLTCDILC 115
Cdd:cd15006   3 TTVQVVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIV-------LSASPHCCWWIYTLLFC 75
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12229835 116 ----------CTSSILNLCVIALDRYWAITDPINyaQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15006  76 kvikflhkvfCSVTVLSFAAIALDRYYSVLYPLE--RKISDAKSRDLVIYIWAHAVVASVP 134
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
42-232 2.73e-06

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 48.59  E-value: 2.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtvaLFV--LPLNVAYRL-LNQWLLGSYLCQM---WLTCDILC 115
Cdd:cd15158  10 ITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDL---LCVctLPLRVVYYVhKGQWLFGDFLCRIssyALYVNLYC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 ctsSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAqfTEDTPC--------TLT 187
Cdd:cd15158  87 ---SIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTE--TNKTKCfeppqsnqQLT 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 12229835 188 QERLFVVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGT 232
Cdd:cd15158 162 KLLVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKARKQQSS 206
7TM_GPCR_Srx pfam10328
Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis ...
43-230 2.82e-06

Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 431215  Cd Length: 262  Bit Score: 48.36  E-value: 2.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835    43 ILVTIVG---NSLVIISVFTYRPLRSVQNFFVVSLAVAD----LTVALFVLPLNVAYRLLNQWLLGSYLCQMWLtcdILC 115
Cdd:pfam10328   1 FLISLIGlvaNLLVFIAFLKLPSLKNSFGILCLSQAIGNaiicLIFLFYVVPMTLFQNSFLPEWLNSHIIGLIA---MGL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835   116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISV-------------PPLLGWndwpaqFTEDT 182
Cdd:pfam10328  78 YEISPLSHLLIALNRFCAVFFPLKYEKIFSIKNTKIIIIFIWIVSIIFCTvfyepegchfyynPETLTW------SFEDT 151
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835   183 PCTLTQERLFVVYSSSGSFFIPLIIMSVVYAKIFF---------ATKRRLRERTRKL 230
Cdd:pfam10328 152 PCCDFITWYLDFYKNLSLVIITLFLNLLTAIKLRVskkksntssSESKRRRKREINF 208
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
43-212 2.83e-06

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 48.25  E-value: 2.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  43 ILVTIVG--NSLVIISVFTYRPLRSVQN-FFVVSLAVADLtvaLFV--LPLNVAYRLL-NQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15370   8 IIVFVVGlpSNAMALWVFLFRTKKKHPAvIYMANLALADL---LFViwFPLKIAYHINgNNWIYGEALCKVLIGFFYGNM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIaAVWALSLVISVPPLLGWNDWPAQFTEDTPC-TLTQERLFVVY 195
Cdd:cd15370  85 YCSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGISL-AIWLLILLVTIPLYLVKQTVFIPALDITTChDVLPEQLLVGD 163
                       170       180
                ....*....|....*....|....
gi 12229835 196 S-------SSGSFFIPLIIMSVVY 212
Cdd:cd15370 164 MfnyflslAIGVFLFPAFLTAVAY 187
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
38-218 2.93e-06

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 48.38  E-value: 2.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlNVAYRLLNQWLLGSY---LCQMWLtCDIL 114
Cdd:cd15918   6 LFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVP-KMLVNIQTQSKSISYagcLTQMYF-FLLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL--------GWNDWPAQFTEDTP--- 183
Cdd:cd15918  84 GDLDNFL-LAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLlmarlsfcASNEIPHFFCDLNPllk 162
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 12229835 184 --CTLTQERLFVVYSSSGS-FFIPLIIMSVVYAKIFFA 218
Cdd:cd15918 163 lsCSDTHLNELVILVLGGLvGLVPFLCILVSYVRIVSA 200
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
42-169 3.78e-06

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 48.12  E-value: 3.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd15159  10 ILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTL-ALPGRIAYYALGfDWPFGDWLCRLTALLFYINTYAGV 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 12229835 121 LNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL 169
Cdd:cd15159  89 NFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLF 137
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
42-230 3.99e-06

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 47.87  E-value: 3.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRllnQWLLGSYLCQMWLTCDILCCTSSIL 121
Cdd:cd15920  10 ICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVL-CLPFRVAYQ---NTAGPLSFCKIVGAFFYLNMYASIL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 NLCVIALDRYWAITDPInyaQKRTIRRVNTMIAA---VWALSLVISVPPLLGWNdwpaqftEDTPCtltQERLF------ 192
Cdd:cd15920  86 FLSLISLDRYLKIIKPL---QQFKIHTVPWSSAAsggVWLLLLACMIPFLFESR-------NEGPC---DNKCFhfrskg 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 12229835 193 -----VVYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKL 230
Cdd:cd15920 153 ltaggINLTAVVIFYILSLLFLYFYAKISHKLYKVSLGNAQQQ 195
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
38-220 4.18e-06

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 47.94  E-value: 4.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVA--------YRLLNQWLLGSYlCQMWL 109
Cdd:cd15359   6 LIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtksqyYNHAIDWQTGSG-CSTAG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 110 TCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDW---PAQFTEDTPCTL 186
Cdd:cd15359  85 FFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYmkvSICLPMDIETLL 164
                       170       180       190
                ....*....|....*....|....*....|....
gi 12229835 187 TQERLFVVYSSSgsfFIPLIIMSVVYAKIFFATK 220
Cdd:cd15359 165 SQAYILLILVLN---VIAFLVICACYIKIYLAVQ 195
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
37-368 4.23e-06

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 47.71  E-value: 4.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADL--TVALFVLPLNVA---YRL-LNQWLLGSYLCQMWLT 110
Cdd:cd15344   5 GLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFfaGLAYFYLMFNTGpntRRLtVSTWLLRQGLIDTSLT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 111 cdilcctSSILNLCVIALDRYWAITDpINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQER 190
Cdd:cd15344  85 -------ASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 191 LFVVYSSSGsfFIPLIIMSVVYAKIFFatkrRLRERTRKLgtlavpappQRTSSRPLAELESVASqedetepspepepls 270
Cdd:cd15344 157 YLVFWAIFN--LVTFVVMVVLYAHIFG----YVRQRTMRM---------SRHSSGPRRNRDTMMS--------------- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 271 sradkpangisvhqfieekqrislskerkAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRvvDFVTWLGYVNS 350
Cdd:cd15344 207 -----------------------------LLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYE--KFFLLLAEFNS 255
                       330
                ....*....|....*...
gi 12229835 351 SLNPIIYTIYNKDFRTAF 368
Cdd:cd15344 256 AMNPIIYSYRDKEMSATF 273
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
40-244 5.21e-06

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 47.46  E-value: 5.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQM--WLTCDILCCt 117
Cdd:cd15968   8 SFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLvrFLFYFNLYG- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 sSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL-----GWNDWPAQFTEDTPCTLTQERLF 192
Cdd:cd15968  87 -SILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIfartgIIRNRTVCYDLAPPALFPHYVPY 165
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 12229835 193 VVYSSSGSFFIPLIIMSVVYAKIffatkrrLRERTRKLGTLAVPAPPQRTSS 244
Cdd:cd15968 166 GMALTVSGFLLPFSIILWCYCLV-------VRTLCRTLGPAEPPAQARRRKS 210
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
37-218 6.14e-06

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 47.06  E-value: 6.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADL-----TValfvlPLNVAYRLLNQWLLgSYL-C--QMW 108
Cdd:cd15227   5 VLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLcyisvTV-----PKSIANSLTNTRSI-SFLgCvaQVF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 109 LTcdILCCTSSILNLCVIALDRYWAITDPINYaqkRTI--RRVNT-MIAAVWALSLVISV--------PPLLGWNDWPaQ 177
Cdd:cd15227  79 LF--IFFAASELALLTVMAYDRYVAICHPLHY---EVImnRGACVqMAAASWLSGLLYGAlhtantfsLPFCGSNVIH-Q 152
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 12229835 178 FTEDTP------CT---LTQERLFVVYSSSGSFFIPLIIMSvvYAKIFFA 218
Cdd:cd15227 153 FFCDIPqllklsCSdtyLNEIGVLVLSVCLGLGCFVFIIVS--YVHIFST 200
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
37-215 8.39e-06

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 46.83  E-value: 8.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVI-ISVFTYRPLRSVqNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15377   5 AVYILVFITGFLGNSVAIwMFVFHMKPWSGI-SVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALsLVISVPPLLGWNDWPAQFTEDTPC--TLTQERL-- 191
Cdd:cd15377  84 LYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLI-VVVAISPILFYSGTGVRKNKTITCydTTSDEYLrs 162
                       170       180
                ....*....|....*....|....*..
gi 12229835 192 FVVYS---SSGSFFIPLIIMSVVYAKI 215
Cdd:cd15377 163 YFIYSmctTVAMFCVPFILILGCYGLI 189
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
37-164 1.01e-05

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 46.67  E-value: 1.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15940   5 MLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFA 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS 164
Cdd:cd15940  85 CTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHS 132
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
38-167 1.07e-05

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 46.32  E-value: 1.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlnvayRLLNQWLLG----SY---LCQMWLT 110
Cdd:cd13954   6 LFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVP-----KMLANLLSGdktiSFsgcLTQLYFF 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835 111 cdILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPP 167
Cdd:cd13954  81 --FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIH 135
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
42-230 1.52e-05

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 46.29  E-value: 1.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRL-LNQWLLGSYLCQMWLTCDILCCTSSI 120
Cdd:cd14987  10 IFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVA-TLPVWVVSLVqHNQWPMGEFTCKITHLIFSINLFGSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 121 LNLCVIALDRYWAITDPINYAQ--KRTIRRVntMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPC------------TL 186
Cdd:cd14987  89 FFLTCMSVDRYLSVTLFGNTSSrrKKIVRRI--ICVLVWLLAFVASLPDTYFLKTVTSPSNNETYCrsfypeesfkewLI 166
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 12229835 187 TQERLFVVYsssgSFFIPLIIMSVVY---AKIFFATKRRLRERTRKL 230
Cdd:cd14987 167 GMELVSIVL----GFVIPFPIIAVFYfllARAISASSDQERKSSRKI 209
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
37-235 1.53e-05

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 45.91  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIIsVFTYRP-LRSVQNFFVVSLAVADLTVALFvLPLnVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15923   5 AIYIPTFVLGLLLNILALW-VFCWRLkKWTETNIYMTNLAVADLLLLIS-LPF-KMHSYRRESAGLQKLCNFVLSLYYIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL--GWNDWPAQFTEdtpCTLTQERLFV 193
Cdd:cd15923  82 MYVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLldSSNEKTMCFQR---TKQTESLKVF 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 12229835 194 VYSSSGSFFIPLIIMSVVYAKIFFATKRRLRERTRKLGTLAV 235
Cdd:cd15923 159 LLLEIFGFLLPLIIMTFCSARVIHTLQKRLDDVGSRSETKQC 200
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
64-230 1.90e-05

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 45.97  E-value: 1.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  64 RSVQNFFVVSLAVADLTVALfVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQK 143
Cdd:cd15166  32 RTTVTVYMMNVALVDLIFIL-SLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIALWLLAFISADRYMAIVQPKHAKEL 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 144 RTIRRVNTMIAAVWALSLVISVPPLLGWNDwPAQFTEDTPCTLTQERLFVVYSSSGS-------FFIPLIIMSVVYAKIF 216
Cdd:cd15166 111 KNTPKAVLACVGVWIMTLASTFPLLFLYED-PDKASNFTTCLKMLDIIHLKEVNVLNftrliffFLIPLFIMIGCYLVII 189
                       170
                ....*....|....
gi 12229835 217 FATkrrLRERTRKL 230
Cdd:cd15166 190 HNL---VHGRTSKL 200
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
37-166 1.91e-05

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 45.88  E-value: 1.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLC--QMWLTCDiL 114
Cdd:cd15424   5 VVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCttQMYIALS-L 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 12229835 115 CCTSSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15424  84 GSTECLL-LGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVI 134
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
39-171 2.13e-05

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 45.57  E-value: 2.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  39 LLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLC--QMWLtcdILCC 116
Cdd:cd15222   7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDAClaQMFF---IHTF 83
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 T---SSIlnLCVIALDRYWAITDPINYAQKRTIRRVNTM--IAAVWALSLVISVPPLLGW 171
Cdd:cd15222  84 SfmeSSV--LLAMAFDRFVAICNPLRYASILTNSRIAKIglAIVLRSVLLLLPLPFLLKR 141
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
38-221 2.48e-05

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 45.28  E-value: 2.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlNVAYRLLNQW---LLGSYLCQMWLTCDIL 114
Cdd:cd15229   6 VFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVP-KMLENLLSERktiSVEGCIAQIFFFFFFA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILNlcVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLV---ISVPPLLG----WNDWPAQFTEDTP---- 183
Cdd:cd15229  85 GTEAFLLS--AMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLyalINTLLLLNlhfcGPNEINHFSCELPsllp 162
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 12229835 184 --CTLTQERLFVVYSSSGSF-FIPLIIMSVVYAKIFFATKR 221
Cdd:cd15229 163 lsCSDTFANKMVLLTSSVIFgLGSFLLTLVSYIHIISTILR 203
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
41-166 2.70e-05

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 45.45  E-value: 2.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLP--LNVAYRLLNQWLLGSYLCQMWLtcdILCCT- 117
Cdd:cd15952   9 AVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPkmLGIFWFNLREISFGGCLAQMFF---IHTFTg 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 -SSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15952  86 mESAV-LVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLP 134
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
70-235 3.01e-05

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 45.14  E-value: 3.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  70 FVVSLAVADLtVALFVLPLNVAYRLL-NQWLLGSYLCQMwltCDILCCTS---SILNLCVIALDRYWAITDPINYAQKRT 145
Cdd:cd15367  38 YLCNLTVADL-LYIFSLPFWLQYVLQhDNWTYSELLCKI---CGILLYENiyiSIGFLCCISVDRYLAVVHPFRFHAFRT 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 146 IRRVNTMIAAVWALSLVISVPPLLGwndwpAQFTEDTPCTL---------TQERLFVVYSSSGSFFIPLIIMSVVYAKIF 216
Cdd:cd15367 114 MKAATLVSTVIWLKELMTCVFFFLH-----GEISKDKENHSvcfehypikAWEHNINYYRFYAGFLFPIFLLSFSYCRIL 188
                       170       180
                ....*....|....*....|....*
gi 12229835 217 FA------TKRRLRERTRKLGTLAV 235
Cdd:cd15367 189 RAvrkshgTQKSQKIQIKRLVLSTV 213
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
44-168 3.07e-05

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 45.36  E-value: 3.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLP--LNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSIl 121
Cdd:cd15223  12 LVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPkmLAIFWFDANTISLPGCFAQMFFIHFFTAMESSI- 90
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 12229835 122 nLCVIALDRYWAITDPINYAQ---KRTIRRVnTMIAAVWALSLVISVPPL 168
Cdd:cd15223  91 -LLVMALDRYVAICKPLRYPSiitKSFILKL-VLFALIRSGLLVLPIVVL 138
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
37-169 3.27e-05

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 45.17  E-value: 3.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlnvayRLLNQWLLG----SYLC---QMWL 109
Cdd:cd15912   5 LLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIP-----KMLANLLSGkktiSFAGcfaQSFF 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 110 tCDILCCTSSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL 169
Cdd:cd15912  80 -YFFLGTTEFFL-LAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTI 137
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
44-169 4.41e-05

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 44.59  E-value: 4.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlnvaYRLLNQWLL------GSYLCQMWLTCDILCCT 117
Cdd:cd15221  12 IVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVP----KMLAIFWFGageisfDGCLTQMFFVHFVFVTE 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 12229835 118 SSIlnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL 169
Cdd:cd15221  88 SAI--LLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVF 137
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
44-365 5.40e-05

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 44.42  E-value: 5.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVG---NSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALF-VLPLNVAyRLLNQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15076   9 FVFIVGtplNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFsVFPVFVA-SAQGYFFFGRTVCALEAFVGSLAGLVT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 120 ILNLCVIALDRYWAITDPI---NYAQKRTIrrvnTMIAAVWALSLVISVPPLLGWN-------------DWPAQFTEDTP 183
Cdd:cd15076  88 GWSLAFLAFERYIVICKPFgnfRFGSKHAL----GAVVATWIIGIGVSLPPFFGWSryipeglqcscgpDWYTVGTKYRS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 184 CTLTQeRLFVVysssgSFFIPLIIMSVVYAKIffatkrrlrertrkLGTLAVPAPPQRtssrplaelESVASQEdeteps 263
Cdd:cd15076 164 EYYTW-FLFIF-----CFIVPLSIIIFSYSQL--------------LGALRAVAAQQQ---------ESASTQK------ 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 264 pepeplssradkpangisvhqfieekqrislsKERKAARVLGVIMGVFVVCWLPF--FLMYaivpFCTNCAPPSQ-RVVD 340
Cdd:cd15076 209 --------------------------------AEREVSRMVVVMVGSFCLCYVPYaaLAMY----MVNNRDHGLDlRLVT 252
                       330       340
                ....*....|....*....|....*
gi 12229835 341 FVTWLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15076 253 IPAFFSKSSCVYNPIIYCFMNKQFR 277
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
39-170 5.73e-05

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 44.18  E-value: 5.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  39 LLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLP--LNVAYRLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPkaLCIFWFNLKEITFSGCLTQMFFIHTLSIM 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12229835 117 TSSIlnLCVIALDRYWAITDPINYAQKRTIRRVNTM--IAAVWALSLVISVPPLLG 170
Cdd:cd15953  87 ESAV--LVAMAFDRYVAICNPLRYATILTNSRIAKLglVGLIRGVLLILPLPLLLS 140
7tmA_PGD2 cd15140
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
61-251 6.19e-05

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor (also called prostanoid DP receptor, DP1, or PGD2R1) is a G-protein coupled receptor whose endogenous ligand is prostaglandin D2 (PGD2). PGD2, the major cyclooxygenase metabolite of arachidonic acid produced by mast cells, mediates inflammatory reactions in response to allergen challenge and causes peripheral vasodilation. PGD2 exerts its biological effects by binding to two types of cell surface receptors: a DP1 receptor that belongs to the prostanoid receptor family and a chemoattractant receptor-homologous molecule expressed on the T-helper type 2 cells (CRTH2 or PD2R2).


Pssm-ID: 320268 [Multi-domain]  Cd Length: 312  Bit Score: 44.50  E-value: 6.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  61 RPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLG------SYLCQMWLTCDILCCTSSILNLCVIALDRYWAI 134
Cdd:cd15140  39 RPRTSVFYVLVTVLTVTDLLGKCLLSPVVLAAYAQNRSLVGltpagnLNLCQVFAFLMIFFGLASTFILLAMALECWLSL 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 135 TDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWpAQFTEDTPC--TLTQERLFV---VYSSSGSFFIPLIIMS 209
Cdd:cd15140 119 GHPFFYQRHINKRLGALVSLILYAFCLGFCALPFFGFGRY-VQYCPGTWCfiQMTAEESSTsalAYSVLYGSLMGLLVLA 197
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 12229835 210 VVYAKI-----FFATKRRLRERTRKLGTLAVP-APPQRTSSRPLAELE 251
Cdd:cd15140 198 IVLCNLgimrnLYQMYRRENEKGIPSTDLQGAaAFPRQQEPAGMEELE 245
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-366 7.28e-05

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 44.00  E-value: 7.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  39 LLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLnVAYRLLNQ--WLLGSYLCQMWLTCDILCC 116
Cdd:cd15189   7 IFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVS-GLPF-WAMNILNQfnWPFGELLCRVVNGVIKVNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL--GWNDWPAQFTedTPCTL-------- 186
Cdd:cd15189  85 YTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLlrKIKAIPDLNI--TACVLlypheawh 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 187 --TQERLFVVysssgSFFIPLIIMSVVYAKIFFATKRRlrertrklgtlavpappqrtssrplaelesvasqedetepsp 264
Cdd:cd15189 163 faHIVLLNIV-----GFLLPLLVITFCNYNILQALRTR------------------------------------------ 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 265 epeplssradkpangisvhqfiEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLMYAIVPFCTNCAPPSQRVVDFV-- 342
Cdd:cd15189 196 ----------------------EESTRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVGVLDECFWEHFIdi 253
                       330       340
                ....*....|....*....|....*....
gi 12229835 343 -----TWLGYVNSSLNPIIYTIYNKDFRT 366
Cdd:cd15189 254 glqlaVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
38-165 7.92e-05

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 43.79  E-value: 7.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15231   6 IFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVG 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAqkRTIRRV--NTMIAAVWALSLVISV 165
Cdd:cd15231  86 TECLLLAVMAYDRYVAICNPLHYA--VIMSRKvcLQLAAASWLCGFLNSA 133
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
41-169 1.04e-04

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 43.60  E-value: 1.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLP--LNVAYRLLNQWLLGSYLCQMWLTCDILCCTS 118
Cdd:cd15955   9 IMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPkmLAIFWFQLREISFNACLAQMFFIHTLQAFES 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 12229835 119 SIlnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL 169
Cdd:cd15955  89 GI--LLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPL 137
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
70-168 1.58e-04

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 43.15  E-value: 1.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  70 FVVSLAVADLTVALfVLPLNVAYRLLNQ-WLLGSYLCQM---WLTCDILcctSSILNLCVIALDRYWAITDPINYAQKRT 145
Cdd:cd15376  39 FSFNLAVSDLLYAL-SLPLLAAYYYPPKnWRFGEAACKLerfLFTCNLY---GSIFFITCISLNRYLGIVHPFFTRSHVR 114
                        90       100
                ....*....|....*....|...
gi 12229835 146 IRRVNTMIAAVWALSLVISVPPL 168
Cdd:cd15376 115 PKHAKLVSLAVWLLVAALSAPVL 137
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
42-166 1.75e-04

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 42.83  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  42 IILVTIVGNSL-VIISVFTYRPlRSVQNFFVVSLAVADLTVAlFVLPLNVAYRLL-NQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15368  10 VALISIPGNLFsLWLLCFHTKP-KTPSIIFMINLSLTDLMLA-CFLPFQIVYHIQrNHWIFGKPLCNVVTVLFYANMYSS 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15368  88 ILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSP 134
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
39-169 2.30e-04

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 42.48  E-value: 2.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  39 LLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtvaLFVLPLNV-AYRLLNQ--WLLGSYLCQMWLTCDILC 115
Cdd:cd15380   7 IIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDL---VFVLGLPFwAENIRNQfnWPFGNFLCRVISGVIKAN 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLL 169
Cdd:cd15380  84 LFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFL 137
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
36-157 2.50e-04

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 42.47  E-value: 2.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  36 TALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15153   4 ATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVL-SLPLRIHYYIQHTWPFGRFLCLLCFYLKYLN 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 12229835 116 CTSSILNLCVIALDRYWAITDPinYAQKRTIRRVNTMI-AAVW 157
Cdd:cd15153  83 MYASICFLTCISIQRCFFLLHP--FKARDWKRRYDVGIsAAVW 123
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
37-165 2.51e-04

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 42.42  E-value: 2.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLC--QMWLTC--- 111
Cdd:cd15945  18 LVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCalQMFFFAafa 97
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 12229835 112 DILCCTssilnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISV 165
Cdd:cd15945  98 DAECLL-----LAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSL 146
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
33-165 2.72e-04

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 42.17  E-value: 2.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  33 VAATALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCD 112
Cdd:cd15938   1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFL 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISV 165
Cdd:cd15938  81 HFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSI 133
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
38-365 2.89e-04

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 42.05  E-value: 2.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIiSVFTYRPLRSVQNFFVVSLAVADLtVALFVLPLNVAYRL-LNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15924   6 LYTVIFFAGILLNGLAM-WIFFHIPSKSSFIIYLKNTVVADL-LMILTFPFKILSDAgLGPWQLRTFVCRVTSVLFYFTM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEDTPCTLTQE-----RL 191
Cdd:cd15924  84 YTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVKKCSFLKSElglkwHE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 192 FVVYSSSGSFFIPLIIMSVVYAKIffatkrrlrerTRKlgtlavpappqrtssrplaelesvasqedetepspepeplss 271
Cdd:cd15924 164 IVNYICQVIFWIVFLLMIVCYTAI-----------TKK------------------------------------------ 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 272 radkpangisVHQFIEEKQRISLSKERKAARVLGVIMGVFVVCWLPFFLmyAIVPFC-------TNCAPPSQ--RVVDFV 342
Cdd:cd15924 191 ----------VYRSYRRVFRSSSSRRKKSNVKIFIIVAVFFVCFVPYHF--ARIPYTlsqtrdvFDCTAENIlfYVKEAT 258
                       330       340
                ....*....|....*....|...
gi 12229835 343 TWLGYVNSSLNPIIYTIYNKDFR 365
Cdd:cd15924 259 LFLSALNVCLDPIIYFFLCKSFR 281
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
38-141 3.96e-04

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 41.62  E-value: 3.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLC--QMWLTCdiLC 115
Cdd:cd15409   6 VFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCaaQFFFFG--FS 83
                        90       100
                ....*....|....*....|....*.
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYA 141
Cdd:cd15409  84 ATTECFLLAAMAYDRYVAICNPLLYP 109
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
44-226 4.20e-04

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 41.63  E-value: 4.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIIS-VFTYRPLRSvQNFFVVSLAVADLtVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILN 122
Cdd:cd15378  12 VLGFIGNTIVILGyIFCLKNWKS-SNIYLFNLSVSDL-AFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLYSSILF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 123 LCVIALDRYWAITDPI--NYAQKRtirRVNTMI-AAVWALsLVISVPPLLGWNDwPAQFTEDTPCtltqerlfVVYSSSG 199
Cdd:cd15378  90 LTFISIDRYLLIKYPFreHILQKK---RSAVAIsLAIWVL-VTLELLPILTFIG-PNLKDNVTKC--------KDYASSG 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 12229835 200 S---------------FFIPLIIMSVVYAKIFFATKRRLRER 226
Cdd:cd15378 157 DatnsliyslfltvtgFLIPLCVMCFFYYKIALFLKNRNRQL 198
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
47-230 4.84e-04

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 41.81  E-value: 4.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835   47 IVGNSLVIISVFTYRPLRSVqNFFVVSLAVADLTVaLFVLPLnVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNLCVI 126
Cdd:PHA02834  43 LIGNVLVIAVLIVKRFMFVV-DVYLFNIAMSDLML-VFSFPF-IIHNDLNEWIFGEFMCKLVLGVYFVGFFSNMFFVTLI 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  127 ALDRYWAITDPINYAQKrTIRRVNTMIAAVWALSLVISVPPLLGW-------------NDWPAQFTEDTpctltqerLFV 193
Cdd:PHA02834 120 SIDRYILVVNATKIKNK-SISLSVLLSVAAWVCSVILSMPAMVLYyvdntdnlkqcifNDYHENFSWSA--------FFN 190
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 12229835  194 VYSSSGSFFIPLIIMSVVYAKIFFATKR-RLRERTRKL 230
Cdd:PHA02834 191 FEINIFGIVIPLIILIYCYSKILYTLKNcKNKNKTRSI 228
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
38-215 5.76e-04

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 41.31  E-value: 5.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVqNFFVVSLAVADLtvalfVLPLNVAYRLLNQ-----WLLGSYLCQMWLTCD 112
Cdd:cd15969   6 LYLIIFIGSILLNGLAVWIFFHIRNKTSF-IFYLKNIVIADL-----LMTLTFPFKIIQDsglgpWNFNFFLCRYTSVLF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPaqfTEDT--PCTLTQER 190
Cdd:cd15969  80 YASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQP---TEDNihDCSKLKSP 156
                       170       180       190
                ....*....|....*....|....*....|.
gi 12229835 191 L------FVVYSSSGSFFIPLIIMSVVYAKI 215
Cdd:cd15969 157 LgvkwhtAVSYINICIFVAVLVILIVCYISI 187
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
38-140 6.40e-04

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 41.15  E-value: 6.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15413   6 LFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFII 85
                        90       100
                ....*....|....*....|...
gi 12229835 118 SSILNLCVIALDRYWAITDPINY 140
Cdd:cd15413  86 SELFLLSAMAYDRYVAICNPLLY 108
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
38-165 6.78e-04

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 40.93  E-value: 6.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlnvayRLLNQWLLG----SY---LCQMWLT 110
Cdd:cd15911   6 LFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILP-----RMLASLLTGdrtiSVsgcIVQFYFF 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 111 CdILCCTSSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISV 165
Cdd:cd15911  81 G-SLAATECYL-LAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLAST 133
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
38-164 7.02e-04

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 41.02  E-value: 7.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlNVAYRLLNQWLLGSY---LCQMWLTCdIL 114
Cdd:cd15234   6 LFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVP-KMLVNIQTQSKSISYtgcLTQMCFFL-LF 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 12229835 115 CCTSSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS 164
Cdd:cd15234  84 GGLDNFL-LAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDS 132
7tmA_GPR149 cd15011
G protein-coupled receptor 149, member of the class A family of seven-transmembrane G ...
38-171 8.04e-04

G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR149 is predominantly expressed in the ovary and is present at low levels in the brain and the digestive tract (stomach and small intestine). GPR149-null mice are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. Additionally, the null mice showed increased expression levels of growth differentiation factor 9 (Gdf9) in oocytes, and upregulated expression of cyclin D2, a downstream target of FSH (follicle-stimulating hormone) receptor signaling pathways that promotes granulosa cell proliferation. GPR149 is an orphan receptor with no known endogenous ligand as yet identified. Although categorized as a member of the class A GPCRs, GPR149 lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors which is important for efficient G protein-coupled signal transduction. Moreover, the transmembrane domains and carboxyl terminus of GPR149 show low similarities to other GPCRs. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320139  Cd Length: 256  Bit Score: 40.52  E-value: 8.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPlRSVQNFFVVSLAVADLtvaLFVLPLNVAyrLLNQW---LLGSYLCQMWLTCDIL 114
Cdd:cd15011   5 LTLIIALLTLLGSIYSLLSLLKMRN-KTTLSVLVASLSVDDL---LSVVPVSIF--MLMQWetdGLPQPLCTTSALLYLF 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12229835 115 CCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGW 171
Cdd:cd15011  79 QGLSSNLKASLIASYNFYTTKKLGWLQTTKRSVRVPWAVLTIWAASLLLSALPLCGW 135
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
47-166 9.24e-04

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 40.65  E-value: 9.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  47 IVGNSLVIISVFTYRPLR-SVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCTSSILNLCV 125
Cdd:cd15926  15 LVGNLLVLYLMKSKQGWKkSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMNMYASVFFLTA 94
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 12229835 126 IALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15926  95 MSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLP 135
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
44-220 1.35e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 40.27  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVA--------YRLLNQWLLGSYlCQMWLTCDILC 115
Cdd:cd15964  12 LLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVdlhtrseyYNHAIDWQTGPG-CNTAGFFTVFA 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQ---FTEDTPCTLTQERLF 192
Cdd:cd15964  91 SELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVsicLPMDTETPLAQAYIV 170
                       170       180
                ....*....|....*....|....*...
gi 12229835 193 VVYSSSgsfFIPLIIMSVVYAKIFFATK 220
Cdd:cd15964 171 FVLMLN---IIAFVIICACYIKIYITVR 195
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
38-164 1.36e-03

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 40.13  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLR-SVQNFFVVSLAVADLTVALFVLPlNVAYRLLNQWLLGSYLCQMWLTCDI-LC 115
Cdd:cd15935   6 LVLACYAAILLGNLLIVVTVHADPHLLqSPMYFFLANLSLIDMTLGSVAVP-KVLADLLTCGRTISFGGCMAQLFFLhFL 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS 164
Cdd:cd15935  85 GGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHS 133
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
37-165 1.36e-03

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 40.08  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLC--QMWLTCDiL 114
Cdd:cd15429   5 VLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCvaQLFISLA-L 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 12229835 115 CCTSSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISV 165
Cdd:cd15429  84 GGTEFIL-LAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSL 133
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
38-215 1.59e-03

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 39.76  E-value: 1.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIiSVFTYRPLRSVQNFFVVSLAVADLTVAlFVLPLNVAY-RLLNQWLLGSYLCQMWLTCDILCC 116
Cdd:cd15151   6 LYTVLFLVGLILNSVAA-WIFFHIPSTSTFIVYLKNTLVADLIMT-LMLPFKILSdSGLGPWQLRAFVCRFSAVVFYITM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 117 TSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLgWNDWPAQFTEDTPCTLTQERL----- 191
Cdd:cd15151  84 YISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMI-LSNKPATPISVKKCASLKSPLglkwh 162
                       170       180
                ....*....|....*....|....*
gi 12229835 192 -FVVYSSSGSFFIPLIIMSVVYAKI 215
Cdd:cd15151 163 eVVNYICQFIFWGVFALMVLFYTII 187
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
38-162 1.62e-03

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 40.04  E-value: 1.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlnvayRLLNQWLLG----SY---LCQMWLT 110
Cdd:cd15406  15 LFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITP-----KMLVNFVSEkniiSYpecMTQLFFF 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 12229835 111 CdiLCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLV 162
Cdd:cd15406  90 C--VFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLI 139
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
40-157 1.65e-03

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 39.72  E-value: 1.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  40 LAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWL-TCDILCCTS 118
Cdd:cd15942   8 LVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLfFFHFLGCAE 87
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 12229835 119 SILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVW 157
Cdd:cd15942  88 CFL-YTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTW 125
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
47-170 1.68e-03

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 39.80  E-value: 1.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  47 IVGNSLVIISVFTYRPLR----SVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLG----SYLCQMWLTCDILCCTS 118
Cdd:cd15141  15 VVGNLLALGILGVHRKERrtksSAFCVLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGlaagQPLCHLFAFAMTFFGLA 94
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 12229835 119 SILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLG 170
Cdd:cd15141  95 SMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFGALFCALPLLG 146
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
37-229 1.75e-03

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 39.72  E-value: 1.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQN-FFVVSLAVADLtVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd14983   5 MVYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDL-VFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFST 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALS-----LVISVPPLLGWNDWPAQFTEDTPC--TLTQ 188
Cdd:cd14983  84 LYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVifhvtLVFILETSGGTLDINTPVGNSSTCyeNFTP 163
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 12229835 189 ERLFVVYS-----SSGSFFIPLIIMSVVYAK-IFFATKRRLRERTRK 229
Cdd:cd14983 164 EQLALLAPvrlelSLVLFFLPLAITAFCYVRcIRILVRSRLHERRKR 210
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
43-166 1.91e-03

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 39.78  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  43 ILVTIVGNSLVIISVFT-YRPLRSV-QNFFVVSLAVADLTVALfVLPLNVAYRLL-NQWLLGSYLCQMWLTCDILCCTSS 119
Cdd:cd15371   8 IIVVVLGVPSNAIILWMlFFRLRSVcTAIFYANLAISDLLFCI-TLPFKIVYHLNgNNWVFGETMCRIITITFYGNMYCS 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 12229835 120 ILNLCVIALDRYWAITDPINYAQ--KRTIRRVntMIAAVWALSLVISVP 166
Cdd:cd15371  87 ILLLTCISINRYLAIVHPFIYRSlpKKTYAVL--ICALVWTIVFLYMLP 133
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
38-165 2.03e-03

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 39.65  E-value: 2.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVI-ISVFTYRPLRSvQNFFVVSLAVADLTVaLFVLPLNVAYRLLN-QWLLGSYLCQMWLTCDILC 115
Cdd:cd15201   6 VLILEFVLGLLGNGLALwIFCFHLKSWKS-STVYLFNLAVADFLL-IICLPFRTDYYLRGkHWKFGDIPCRIVLFMLAMN 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISV 165
Cdd:cd15201  84 RAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTV 133
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
37-140 2.16e-03

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 39.32  E-value: 2.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVT-IVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRLLNQWLLGSYLCQMWLTCDILC 115
Cdd:cd15152   4 AVTYTVILIPgLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVL-SLPLRIFYYLNKSWPFGKFLCMFCFYLKYVN 82
                        90       100
                ....*....|....*....|....*
gi 12229835 116 CTSSILNLCVIALDRYWAITDPINY 140
Cdd:cd15152  83 MYASIYFLVCISVRRCLYLIYPFRY 107
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
57-224 2.28e-03

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 39.45  E-value: 2.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  57 VFTYRPLRSVQNFFVVSLAVADLTVALfVLPLNVAYRL-LNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAIT 135
Cdd:cd15149  24 IFFYVPSNKSFIVYLKNIVFADLLMSL-TFPFKILSDVeLGPWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIV 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 136 DPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQFTEdTPCTLTQERLFVVYSSSGSF---------FIPLI 206
Cdd:cd15149 103 KPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSFHEANY-TKCARLKSELGIQWHKASNYicvsifwvvFLLLI 181
                       170
                ....*....|....*...
gi 12229835 207 IMSVVYAKIFFATKRRLR 224
Cdd:cd15149 182 IFYVAISRKIYKSNQKFR 199
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
38-170 2.30e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 39.46  E-value: 2.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPL-NVAYRLLNQWLLGSYLCQMWLTCD---- 112
Cdd:cd15360   6 LIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIaSVDIRTKSQYYNYAIDWQTGAGCAaagf 85
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 113 --ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLG 170
Cdd:cd15360  86 ftVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFG 145
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
38-160 2.33e-03

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 39.34  E-value: 2.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWL--LGSYLCQMWLTcDILC 115
Cdd:cd15228   6 LFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVisLGGCMSQVFFY-HFLG 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 12229835 116 CTSSILnLCVIALDRYWAITDPINYAQKRTiRRVNTMIAAV-WALS 160
Cdd:cd15228  85 STECLL-YTVMAYDRYVAICHPLRYLLIMN-RRVCALLAAGtWITS 128
7tmA_FP cd15145
prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G ...
45-177 2.50e-03

prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The PGF2-alpha receptor, also called prostanoid FP receptor, is a class A G-protein coupled receptor whose endogenous ligand is prostaglandin F2-alpha. PGF2-alpha binding to this receptor is coupled to the stimulation of phospholipase C (PLC) pathway via G-protein subunit G(q). This leads to the release of inositol trisphosphate (IP3) and diacylglycerol (DAG) which results in increased intracellular Ca2+ levels and activation of PKC. The receptor activation primarily induces uterine contraction and bronchoconstriction, and stimulates luteolysis. Like most prostanoid receptors, the PGF2-alpha receptor has also been implicated in tumor angiogenesis and metastasis.


Pssm-ID: 320273 [Multi-domain]  Cd Length: 290  Bit Score: 39.42  E-value: 2.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  45 VTIVGNSLVI-ISVFTYRPLR--SVQNF--FVVSLAVADL-------TVALFVLPLNVAYRLLNQwllGSYLCQMWLTCD 112
Cdd:cd15145  13 VGILSNSLAIaILMKAYQRFRqkSKASFllLASGLVITDFfghlingTIAVFVYASDKDWIRFDQ---SNILCSVFGICM 89
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 113 ILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQ 177
Cdd:cd15145  90 VFFGLCPLLLGSVMAVERCIGVTKPIFHSTKMTSKHVKMMLSGVCLFAVLVALLPILGHRDYQIQ 154
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
37-140 2.57e-03

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 39.27  E-value: 2.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  37 ALLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPlnvayRLLNQWLLG----SYL-CQMWLTC 111
Cdd:cd15943  19 AVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITP-----KMLVNFLAEnktiSFTgCAAQMYF 93
                        90       100
                ....*....|....*....|....*....
gi 12229835 112 DILCCTSSILNLCVIALDRYWAITDPINY 140
Cdd:cd15943  94 FVAFATTECFLLAVMAYDRYVAICNPLLY 122
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
38-162 4.47e-03

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 38.61  E-value: 4.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15944  19 VFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVD 98
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLV 162
Cdd:cd15944  99 AECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLV 143
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
41-175 4.62e-03

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 38.48  E-value: 4.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLC--QMWLtcdILCCT- 117
Cdd:cd15951   9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACltQMFF---IHSFSt 85
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12229835 118 --SSIlnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVW--ALSLVISVPPLLGWndWP 175
Cdd:cd15951  86 meSGI--FVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVlrGGILVSPHPFLLRR--LP 143
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
68-169 4.93e-03

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 38.23  E-value: 4.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  68 NFFVVSLAVADLTVALfVLPLNVAYRL-LNQWLLGSYLCQMWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTI 146
Cdd:cd15199  36 AVYLLNLVLADVLLLI-CLPFKAYFYLnGNRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSL 114
                        90       100
                ....*....|....*....|...
gi 12229835 147 RRVNTMIAAVWALSLVISVPPLL 169
Cdd:cd15199 115 QAAPYISFLVWLLLVGLTIPTLL 137
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
70-169 5.23e-03

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 38.20  E-value: 5.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  70 FVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLCQM--WLTCDILCCtsSILNLCVIALDRYWAITDPINYAQKRTIR 147
Cdd:cd16001  38 YLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLvrFLFYTNLYG--SILFLTCISVHRFLGVCYPIRSLAYRTRR 115
                        90       100
                ....*....|....*....|..
gi 12229835 148 RVNTMIAAVWALSLVISVPPLL 169
Cdd:cd16001 116 LAVIGSAATWILVVLQLLPTLV 137
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
34-230 5.43e-03

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 38.64  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835   34 AATALLLAIILVTIVGNSLVIIS-VFTYRPLR-SVQNFFVVSLAVADLtVALFVLPLNVayrLLNQWLLGSYLcqmwLTC 111
Cdd:PHA03235  34 TETFINLLIISVGGPLNLIVLVTqLLANRVHGfSTPTLYMTNLYLANL-LTVFVLPFIM---LSNQGLLSGSV----AGC 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  112 DILC------CTSSILNLCVIALDRYWAITDPInYAQKRTIRRVNTMIAAVWALSLVISVPP-----LLGWNDWPAQFTE 180
Cdd:PHA03235 106 KFASllyyasCTVGFATVALIAADRYRVIHQRT-RARSSAYRSTYKILGLTWFASLICSGPApvyttVVAHDDVDPEAPG 184
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12229835  181 DTPCTLtqerLFV---VYSSSGSF---------FIPLIIMSVVYAkIFFATKRRL--RERTRKL 230
Cdd:PHA03235 185 YETCVI----YFRadqVKTVLSTFkvlltlvwgIAPVVMMTWFYT-FFYRTLKRAsyKKRSRTL 243
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
44-166 5.61e-03

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 38.16  E-value: 5.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  44 LVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYLC--QMWLTCDILCCTSSIl 121
Cdd:cd15950  12 VIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACftQMFFVHSFTAVESGV- 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 12229835 122 nLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVP 166
Cdd:cd15950  91 -LLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTP 134
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
41-166 6.06e-03

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 38.32  E-value: 6.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  41 AIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLtvaLFV--LPLNV-AYRLLNQWLLGSYLCQMWLTCDILCCT 117
Cdd:cd15379   9 VVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADL---LYVcsLPLLIyNYTQKDYWPFGDFTCRLVRFQFYTNLH 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 12229835 118 SSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMI-AAVWALSLVISVP 166
Cdd:cd15379  86 GSILFLTCISVQRYLGICHPLASWHKKKGKKLTWLVcGAVWLVVIAQCLP 135
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
51-232 6.56e-03

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 37.95  E-value: 6.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  51 SLVIISVFTYRPLRSVQNFfVVSLAVADLTVALFVLPLNVayrLLNQWLLGSYLCQMW-LTCDILCCTS---SILNLCVI 126
Cdd:cd15919  21 TVIILSQLVARRQKSSYNY-LLALAAADILVLFFIVFVDF---LLEDFILNKQMPQVLdKIIEVLEFSSihtSIWITVPL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835 127 ALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPpllgWNDWPAQFTEDTPCTLTQERLFVVYSSSgSFFIPLI 206
Cdd:cd15919  97 TIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIP----YYWWPNIWIEDYTSTSMHHVLIWIHCFT-VYLVPCS 171
                       170       180
                ....*....|....*....|....*.
gi 12229835 207 IMSVVYAKIFFATKRRLRERTRKLGT 232
Cdd:cd15919 172 IFFVLNSIIVYKLRRKSNFRLRGYST 197
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
38-164 6.82e-03

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 38.06  E-value: 6.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLL--GSYLCQMWLTcDILC 115
Cdd:cd15915   6 LFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTIsfQGCISQLHFF-HFLG 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 12229835 116 CTSSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVIS 164
Cdd:cd15915  85 SSEAML-LAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHA 132
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
38-158 6.99e-03

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 37.81  E-value: 6.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  38 LLLAIILVTIVGNSLVIISVFTYRPLRSVQNFFVVSLAVADLTVALFVLPLNVAYRLLNQWLLGSYL-CQMWLTC-DILC 115
Cdd:cd15916   6 IFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGKVISFGgCVAQLYFfHFLG 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 12229835 116 CTSSILnLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWA 158
Cdd:cd15916  86 STECFL-YTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWV 127
7tmA_PGE2_EP3 cd15146
prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G ...
35-178 7.80e-03

prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP3, also called prostanoid EP3 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP3 receptor by PGE2 preferentially couples to G(i) protein. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels, which subsequently produces smooth muscle contraction. Knockout mice studies suggest that the EP3 receptor may act as a systemic vasopressor. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320274 [Multi-domain]  Cd Length: 308  Bit Score: 37.94  E-value: 7.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229835  35 ATALLLAIILVTIVGNSLVIISVftYRPLRSVQN-------FFVVSLAVADLTVALFVLPLNVA-YRLLNQWL---LGSY 103
Cdd:cd15146   3 SVAFPITMMITGMVGNALAMLLV--YRSYRKKENkrkrsflLCIGSLALTDLFGQLLTSPIVISvYLSDRKWErvdPSGR 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12229835 104 LCQMWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQF 178
Cdd:cd15146  81 LCPFFGLCMTVFGLCPLFIASAMAIERALAIRAPHWYSSHMKTRVTKAVLLGIWLAVLAFALLPIAGVGQYTLQW 155
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
101-178 9.58e-03

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 37.45  E-value: 9.58e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12229835 101 GSYLCQMWLTCDILCCTSSILNLCVIALDRYWAITDPINYAQKRTIRRVNTMIAAVWALSLVISVPPLLGWNDWPAQF 178
Cdd:cd15144  77 RGALCQFFGACMVFFGLCPLFLGCAMAVERCVGVTRPLLHSSVVTTTRTKLSLLAIWAVALAVALLPLFRFGRYKPQF 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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