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Conserved domains on  [gi|75306336|sp|Q94AT3|]
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RecName: Full=Pseudouridine kinase

Protein Classification

carbohydrate kinase family protein( domain architecture ID 10112596)

carbohydrate kinase family protein that accepts a wide variety of substrates, including carbohydrates and aromatic small molecules, all being phosphorylated at a hydroxyl group; similar to Arabidopsis thaliana pseudouridine kinase that catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP)

CATH:  3.40.1190.20
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0016301|GO:0005975
PubMed:  8382990
SCOP:  4000759

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YeiC_kinase_like cd01941
YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ...
 2-344 2.87e-87

YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time.


:

Pssm-ID: 238916 [Multi-domain]  Cd Length: 288  Bit Score: 265.33  E-value: 2.87e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   2 EPVIIGALILDVHAKPSTTPISGTTVPGQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEwkLSMKGILR 81
Cdd:cd01941   1 EIVVIGAANIDLRGKVSGSLVPGTSNPGHVKQSPGGVGRNIAENLARLGVSVALLSAVGDDSEGESILEE--SEKAGLNV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  82 R----EDISTPIVSLVYDTNGEVAAGVAGVDAVENfLTPEWIQRFEYNISSARLLMVDANLSSLALEASCKLAAESSVPV 157
Cdd:cd01941  79 RgivfEGRSTASYTAILDKDGDLVVALADMDIYEL-LTPDFLRKIREALKEAKPIVVDANLPEEALEYLLALAAKHGVPV 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 158 WFEPVSVTKSQRIASIAKYVTIVSPNQDELIAMANALCAKNLFHpfrsdenklsiedmfralKPAILVLLKNGVKVVIVT 237
Cdd:cd01941 158 AFEPTSAPKLKKLFYLLHAIDLLTPNRAELEALAGALIENNEDE------------------NKAAKILLLPGIKNVIVT 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 238 LGSNGALLCSkgnpkkalnidrkflrsgevfkrvqsvcspnrfselgsnRSPSLFAMHFPTI-PAKVKKLTGAGDCLVGG 316
Cdd:cd01941 220 LGAKGVLLSS---------------------------------------REGGVETKLFPAPqPETVVNVTGAGDAFVAG 260

                       330       340
                ....*....|....*....|....*...
gi 75306336 317 TVASLSDGLDLIQSLAVGIASAKAAVES 344
Cdd:cd01941 261 LVAGLLEGMSLDDSLRFAQAAAALTLES 288
 
Name Accession Description Interval E-value
YeiC_kinase_like cd01941
YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ...
 2-344 2.87e-87

YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time.


Pssm-ID: 238916 [Multi-domain]  Cd Length: 288  Bit Score: 265.33  E-value: 2.87e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   2 EPVIIGALILDVHAKPSTTPISGTTVPGQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEwkLSMKGILR 81
Cdd:cd01941   1 EIVVIGAANIDLRGKVSGSLVPGTSNPGHVKQSPGGVGRNIAENLARLGVSVALLSAVGDDSEGESILEE--SEKAGLNV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  82 R----EDISTPIVSLVYDTNGEVAAGVAGVDAVENfLTPEWIQRFEYNISSARLLMVDANLSSLALEASCKLAAESSVPV 157
Cdd:cd01941  79 RgivfEGRSTASYTAILDKDGDLVVALADMDIYEL-LTPDFLRKIREALKEAKPIVVDANLPEEALEYLLALAAKHGVPV 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 158 WFEPVSVTKSQRIASIAKYVTIVSPNQDELIAMANALCAKNLFHpfrsdenklsiedmfralKPAILVLLKNGVKVVIVT 237
Cdd:cd01941 158 AFEPTSAPKLKKLFYLLHAIDLLTPNRAELEALAGALIENNEDE------------------NKAAKILLLPGIKNVIVT 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 238 LGSNGALLCSkgnpkkalnidrkflrsgevfkrvqsvcspnrfselgsnRSPSLFAMHFPTI-PAKVKKLTGAGDCLVGG 316
Cdd:cd01941 220 LGAKGVLLSS---------------------------------------REGGVETKLFPAPqPETVVNVTGAGDAFVAG 260

                       330       340
                ....*....|....*....|....*...
gi 75306336 317 TVASLSDGLDLIQSLAVGIASAKAAVES 344
Cdd:cd01941 261 LVAGLLEGMSLDDSLRFAQAAAALTLES 288
RbsK COG0524
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar ...
 4-344 8.27e-28

Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar or nucleoside kinase, ribokinase family is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440290 [Multi-domain]  Cd Length: 301  Bit Score: 110.74  E-value: 8.27e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   4 VIIGALILDVHAKPSTTPISGTTVPG-QVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWK---LSMKGI 79
Cdd:COG0524   3 LVIGEALVDLVARVDRLPKGGETVLAgSFRRSPGGAAANVAVALARLGARVALVGAVGDDPFGDFLLAELRaegVDTSGV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  80 LRREDISTPIVSLVYDTNGEvaAGVAGVDAVENFLTPEWIQrfEYNISSARLLMVDANLSSL-----ALEASCKLAAESS 154
Cdd:COG0524  83 RRDPGAPTGLAFILVDPDGE--RTIVFYRGANAELTPEDLD--EALLAGADILHLGGITLASeppreALLAALEAARAAG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 155 VPVWFEPVSVTK-----SQRIASIAKYVTIVSPNQDELIAMANalcaknlfhpfrsdenKLSIEDMFRALkpailvlLKN 229
Cdd:COG0524 159 VPVSLDPNYRPAlwepaRELLRELLALVDILFPNEEEAELLTG----------------ETDPEEAAAAL-------LAR 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 230 GVKVVIVTLGSNGALLCSKgnpkkalnidrkflrsGEVFkrvqsvcspnrfselgsnrspslfamHFPTIPAKVKKLTGA 309
Cdd:COG0524 216 GVKLVVVTLGAEGALLYTG----------------GEVV--------------------------HVPAFPVEVVDTTGA 253

                       330       340       350
                ....*....|....*....|....*....|....*
gi 75306336 310 GDCLVGGTVASLSDGLDLIQSLAVGIASAKAAVES 344
Cdd:COG0524 254 GDAFAAGFLAGLLEGLDLEEALRFANAAAALVVTR 288
PfkB pfam00294
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ...
 4-344 6.24e-25

pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases.


Pssm-ID: 425587 [Multi-domain]  Cd Length: 294  Bit Score: 102.81  E-value: 6.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336     4 VIIGALILDVHAKPSTTPISGTTVPgQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWK---LSMKGIL 80
Cdd:pfam00294   3 VVIGEANIDLIGNVEGLPGELVRVS-TVEKGPGGKGANVAVALARLGGDVAFIGAVGDDNFGEFLLQELKkegVDTDYVV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336    81 RREDISTPIVSLVYDTNGEVaaGVAGVDAVENFLTPEWIQRFEYNISSARLLMVDANLSSLALEASCKLAAES------S 154
Cdd:pfam00294  82 IDEDTRTGTALIEVDGDGER--TIVFNRGAAADLTPEELEENEDLLENADLLYISGSLPLGLPEATLEELIEAaknggtF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   155 VPVWFEPVSVTKsQRIASIAKYVTIVSPNQDELIAMANalcaknlfhpfrsdENKLSIEDmfraLKPAILVLLKNGVKVV 234
Cdd:pfam00294 160 DPNLLDPLGAAR-EALLELLPLADLLKPNEEELEALTG--------------AKLDDIEE----ALAALHKLLAKGIKTV 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   235 IVTLGSNGALLCSKGnpkkalnidrkflrsGEVfkrvqsvcspnrfselgsnrspslfamHFPTIPA-KVKKLTGAGDCL 313
Cdd:pfam00294 221 IVTLGADGALVVEGD---------------GEV---------------------------HVPAVPKvKVVDTTGAGDSF 258

                         330       340       350
                  ....*....|....*....|....*....|.
gi 75306336   314 VGGTVASLSDGLDLIQSLAVGIASAKAAVES 344
Cdd:pfam00294 259 VGGFLAGLLAGKSLEEALRFANAAAALVVQK 289
PTZ00292 PTZ00292
ribokinase; Provisional
 4-337 1.37e-14

ribokinase; Provisional


Pssm-ID: 185541 [Multi-domain]  Cd Length: 326  Bit Score: 74.00  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336    4 VIIGALILDVHAKPSTTPISGTTVPG---QVLFapGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWK---LSMK 77
Cdd:PTZ00292  19 VVVGSSNTDLIGYVDRMPQVGETLHGtsfHKGF--GGKGANQAVMASKLGAKVAMVGMVGTDGFGSDTIKNFKrngVNTS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   78 GILRREDISTPIVSLVYDT----NGEVAAGVAgvdavENFLTPEWIQRFEYNI-SSARLLMVDANLSSLALEASCKLAAE 152
Cdd:PTZ00292  97 FVSRTENSSTGLAMIFVDTktgnNEIVIIPGA-----NNALTPQMVDAQTDNIqNICKYLICQNEIPLETTLDALKEAKE 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  153 SSVPVWFEP---VSVTKSQRIASIAKYVTIVSPNQDELIAMANalcaknlfhpfrsdenkLSIEDMFRALKpAILVLLKN 229
Cdd:PTZ00292 172 RGCYTVFNPapaPKLAEVEIIKPFLKYVSLFCVNEVEAALITG-----------------MEVTDTESAFK-ASKELQQL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  230 GVKVVIVTLGSNGALLCSKGNPKkalnidrkflrsgevfkrvqsvcspnrfselgsnrspslfaMHFPTIPAKVKKLTGA 309
Cdd:PTZ00292 234 GVENVIITLGANGCLIVEKENEP-----------------------------------------VHVPGKRVKAVDTTGA 272

                        330       340       350
                 ....*....|....*....|....*....|
gi 75306336  310 GDCLVGGTVASLSDGLDLIQSL--AVGIAS 337
Cdd:PTZ00292 273 GDCFVGSMAYFMSRGKDLKESCkrANRIAA 302
 
Name Accession Description Interval E-value
YeiC_kinase_like cd01941
YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ...
 2-344 2.87e-87

YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time.


Pssm-ID: 238916 [Multi-domain]  Cd Length: 288  Bit Score: 265.33  E-value: 2.87e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   2 EPVIIGALILDVHAKPSTTPISGTTVPGQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEwkLSMKGILR 81
Cdd:cd01941   1 EIVVIGAANIDLRGKVSGSLVPGTSNPGHVKQSPGGVGRNIAENLARLGVSVALLSAVGDDSEGESILEE--SEKAGLNV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  82 R----EDISTPIVSLVYDTNGEVAAGVAGVDAVENfLTPEWIQRFEYNISSARLLMVDANLSSLALEASCKLAAESSVPV 157
Cdd:cd01941  79 RgivfEGRSTASYTAILDKDGDLVVALADMDIYEL-LTPDFLRKIREALKEAKPIVVDANLPEEALEYLLALAAKHGVPV 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 158 WFEPVSVTKSQRIASIAKYVTIVSPNQDELIAMANALCAKNLFHpfrsdenklsiedmfralKPAILVLLKNGVKVVIVT 237
Cdd:cd01941 158 AFEPTSAPKLKKLFYLLHAIDLLTPNRAELEALAGALIENNEDE------------------NKAAKILLLPGIKNVIVT 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 238 LGSNGALLCSkgnpkkalnidrkflrsgevfkrvqsvcspnrfselgsnRSPSLFAMHFPTI-PAKVKKLTGAGDCLVGG 316
Cdd:cd01941 220 LGAKGVLLSS---------------------------------------REGGVETKLFPAPqPETVVNVTGAGDAFVAG 260

                       330       340
                ....*....|....*....|....*...
gi 75306336 317 TVASLSDGLDLIQSLAVGIASAKAAVES 344
Cdd:cd01941 261 LVAGLLEGMSLDDSLRFAQAAAALTLES 288
RbsK COG0524
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar ...
 4-344 8.27e-28

Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar or nucleoside kinase, ribokinase family is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440290 [Multi-domain]  Cd Length: 301  Bit Score: 110.74  E-value: 8.27e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   4 VIIGALILDVHAKPSTTPISGTTVPG-QVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWK---LSMKGI 79
Cdd:COG0524   3 LVIGEALVDLVARVDRLPKGGETVLAgSFRRSPGGAAANVAVALARLGARVALVGAVGDDPFGDFLLAELRaegVDTSGV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  80 LRREDISTPIVSLVYDTNGEvaAGVAGVDAVENFLTPEWIQrfEYNISSARLLMVDANLSSL-----ALEASCKLAAESS 154
Cdd:COG0524  83 RRDPGAPTGLAFILVDPDGE--RTIVFYRGANAELTPEDLD--EALLAGADILHLGGITLASeppreALLAALEAARAAG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 155 VPVWFEPVSVTK-----SQRIASIAKYVTIVSPNQDELIAMANalcaknlfhpfrsdenKLSIEDMFRALkpailvlLKN 229
Cdd:COG0524 159 VPVSLDPNYRPAlwepaRELLRELLALVDILFPNEEEAELLTG----------------ETDPEEAAAAL-------LAR 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 230 GVKVVIVTLGSNGALLCSKgnpkkalnidrkflrsGEVFkrvqsvcspnrfselgsnrspslfamHFPTIPAKVKKLTGA 309
Cdd:COG0524 216 GVKLVVVTLGAEGALLYTG----------------GEVV--------------------------HVPAFPVEVVDTTGA 253

                       330       340       350
                ....*....|....*....|....*....|....*
gi 75306336 310 GDCLVGGTVASLSDGLDLIQSLAVGIASAKAAVES 344
Cdd:COG0524 254 GDAFAAGFLAGLLEGLDLEEALRFANAAAALVVTR 288
PfkB pfam00294
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ...
 4-344 6.24e-25

pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases.


Pssm-ID: 425587 [Multi-domain]  Cd Length: 294  Bit Score: 102.81  E-value: 6.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336     4 VIIGALILDVHAKPSTTPISGTTVPgQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWK---LSMKGIL 80
Cdd:pfam00294   3 VVIGEANIDLIGNVEGLPGELVRVS-TVEKGPGGKGANVAVALARLGGDVAFIGAVGDDNFGEFLLQELKkegVDTDYVV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336    81 RREDISTPIVSLVYDTNGEVaaGVAGVDAVENFLTPEWIQRFEYNISSARLLMVDANLSSLALEASCKLAAES------S 154
Cdd:pfam00294  82 IDEDTRTGTALIEVDGDGER--TIVFNRGAAADLTPEELEENEDLLENADLLYISGSLPLGLPEATLEELIEAaknggtF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   155 VPVWFEPVSVTKsQRIASIAKYVTIVSPNQDELIAMANalcaknlfhpfrsdENKLSIEDmfraLKPAILVLLKNGVKVV 234
Cdd:pfam00294 160 DPNLLDPLGAAR-EALLELLPLADLLKPNEEELEALTG--------------AKLDDIEE----ALAALHKLLAKGIKTV 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   235 IVTLGSNGALLCSKGnpkkalnidrkflrsGEVfkrvqsvcspnrfselgsnrspslfamHFPTIPA-KVKKLTGAGDCL 313
Cdd:pfam00294 221 IVTLGADGALVVEGD---------------GEV---------------------------HVPAVPKvKVVDTTGAGDSF 258

                         330       340       350
                  ....*....|....*....|....*....|.
gi 75306336   314 VGGTVASLSDGLDLIQSLAVGIASAKAAVES 344
Cdd:pfam00294 259 VGGFLAGLLAGKSLEEALRFANAAAALVVQK 289
ribokinase cd01174
Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This ...
 4-343 2.12e-21

Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.


Pssm-ID: 238579 [Multi-domain]  Cd Length: 292  Bit Score: 93.00  E-value: 2.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   4 VIIGALILDVHAKPSTTPISGTTVPGQVLF-APGGVARNVADCIFKLGITPFMIGTLGLDGPANVL---LKEWKLSMKGI 79
Cdd:cd01174   3 VVVGSINVDLVTRVDRLPKPGETVLGSSFEtGPGGKGANQAVAAARLGARVAMIGAVGDDAFGDELlenLREEGIDVSYV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  80 LRREDISTPIVSLVYDTNGE----VAAGVAGvdavenFLTPEWIQRFEYNISSARLLMVDANLSSLALEASCKLAAESSV 155
Cdd:cd01174  83 EVVVGAPTGTAVITVDESGEnrivVVPGANG------ELTPADVDAALELIAAADVLLLQLEIPLETVLAALRAARRAGV 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 156 PVWFEPVSVTKsqRIASIAKYVTIVSPNQDELIAMANALcaknlfhpfrsdenKLSIEDMFRALKpailVLLKNGVKVVI 235
Cdd:cd01174 157 TVILNPAPARP--LPAELLALVDILVPNETEAALLTGIE--------------VTDEEDAEKAAR----LLLAKGVKNVI 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 236 VTLGSNGALLCSKgnpkkalnidrkflrsGEVFkrvqsvcspnrfselgsnrspslfamHFPTIPAKVKKLTGAGDCLVG 315
Cdd:cd01174 217 VTLGAKGALLASG----------------GEVE--------------------------HVPAFKVKAVDTTGAGDTFIG 254

                       330       340
                ....*....|....*....|....*...
gi 75306336 316 GTVASLSDGLDLIQSLAVGIASAKAAVE 343
Cdd:cd01174 255 ALAAALARGLSLEEAIRFANAAAALSVT 282
PTZ00292 PTZ00292
ribokinase; Provisional
 4-337 1.37e-14

ribokinase; Provisional


Pssm-ID: 185541 [Multi-domain]  Cd Length: 326  Bit Score: 74.00  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336    4 VIIGALILDVHAKPSTTPISGTTVPG---QVLFapGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWK---LSMK 77
Cdd:PTZ00292  19 VVVGSSNTDLIGYVDRMPQVGETLHGtsfHKGF--GGKGANQAVMASKLGAKVAMVGMVGTDGFGSDTIKNFKrngVNTS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   78 GILRREDISTPIVSLVYDT----NGEVAAGVAgvdavENFLTPEWIQRFEYNI-SSARLLMVDANLSSLALEASCKLAAE 152
Cdd:PTZ00292  97 FVSRTENSSTGLAMIFVDTktgnNEIVIIPGA-----NNALTPQMVDAQTDNIqNICKYLICQNEIPLETTLDALKEAKE 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  153 SSVPVWFEP---VSVTKSQRIASIAKYVTIVSPNQDELIAMANalcaknlfhpfrsdenkLSIEDMFRALKpAILVLLKN 229
Cdd:PTZ00292 172 RGCYTVFNPapaPKLAEVEIIKPFLKYVSLFCVNEVEAALITG-----------------MEVTDTESAFK-ASKELQQL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  230 GVKVVIVTLGSNGALLCSKGNPKkalnidrkflrsgevfkrvqsvcspnrfselgsnrspslfaMHFPTIPAKVKKLTGA 309
Cdd:PTZ00292 234 GVENVIITLGANGCLIVEKENEP-----------------------------------------VHVPGKRVKAVDTTGA 272

                        330       340       350
                 ....*....|....*....|....*....|
gi 75306336  310 GDCLVGGTVASLSDGLDLIQSL--AVGIAS 337
Cdd:PTZ00292 273 GDCFVGSMAYFMSRGKDLKESCkrANRIAA 302
FruK COG1105
1-phosphofructokinase or 6-phosphofructokinase II [Carbohydrate transport and metabolism];
177-346 7.87e-12

1-phosphofructokinase or 6-phosphofructokinase II [Carbohydrate transport and metabolism];


Pssm-ID: 440722 [Multi-domain]  Cd Length: 304  Bit Score: 65.54  E-value: 7.87e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 177 VTIVSPNQDELIAMANalcaknlfHPFRSDEnklsiedmfrALKPAILVLLKNGVKVVIVTLGSNGALLCSKGNpkkaln 256
Cdd:COG1105 178 PDLIKPNLEELEELLG--------RPLETLE----------DIIAAARELLERGAENVVVSLGADGALLVTEDG------ 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 257 idrkflrsgevfkrvqsvcspnrfselgsnrspslfAMHFPTIPAKVKKLTGAGDCLVGGTVASLSDGLDLIQSLAVGIA 336
Cdd:COG1105 234 ------------------------------------VYRAKPPKVEVVSTVGAGDSMVAGFLAGLARGLDLEEALRLAVA 277

                       170
                ....*....|
gi 75306336 337 SAKAAVESDD 346
Cdd:COG1105 278 AGAAAALSPG 287
PRK09850 PRK09850
pseudouridine kinase; Provisional
 4-354 1.80e-11

pseudouridine kinase; Provisional


Pssm-ID: 182111 [Multi-domain]  Cd Length: 313  Bit Score: 64.62  E-value: 1.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336    4 VIIGALILDVhAKPSTTPIS-GTTVPGQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWKLSM----KG 78
Cdd:PRK09850   8 VIIGSANIDV-AGYSHESLNyADSNPGKIKFTPGGVGRNIAQNLALLGNKAWLLSAVGSDFYGQSLLTQTNQSGvyvdKC 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   79 ILRREDISTPIVSLVyDTNGEVAAGVAGVdAVENFLTPEWIQRFEYNISSARLLMVDANLSSLALEASCKLAAEssVPVW 158
Cdd:PRK09850  87 LIVPGENTSSYLSLL-DNTGEMLVAINDM-NISNAITAEYLAQHREFIQRAKVIVADCNISEEALAWILDNAAN--VPVF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  159 FEPVSVTKSQRIASIAKYVTIVSPNQDEliamANALCAKNLfhPFRSDENKLSIedMFRalkpailvllKNGVKVVIVTL 238
Cdd:PRK09850 163 VDPVSAWKCVKVRDRLNQIHTLKPNRLE----AETLSGIAL--SGREDVAKVAA--WFH----------QHGLNRLVLSM 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  239 GSNGALlcskgnpkkalnidrkflrsgevfkrvqsvcspnrFSELGSNRSPSlfamhfPTIPAKVKKLTGAGDCLVGGTV 318
Cdd:PRK09850 225 GGDGVY-----------------------------------YSDISGESGWS------APIKTNVINVTGAGDAMMAGLA 263

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 75306336  319 ASLSDGLDLIQSL--AVGIASAKAAVESDDNvpPEFKL 354
Cdd:PRK09850 264 SCWVDGMPFAESVrfAQGCSSMALSCEYTNN--PDLSI 299
FruK_PfkB_like cd01164
1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. ...
 171-346 3.01e-11

1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.


Pssm-ID: 238570 [Multi-domain]  Cd Length: 289  Bit Score: 63.32  E-value: 3.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 171 ASIAKYVTIVSPNQDELIAMANalcaknlfHPFRSDEnklsiedmfrALKPAILVLLKNGVKVVIVTLGSNGALLCSKGN 250
Cdd:cd01164 172 AALAAKPFLIKPNREELEELFG--------RPLGDEE----------DVIAAARKLIERGAENVLVSLGADGALLVTKDG 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 251 pkkalnidrkflrsgevfkrvqsvcspnrfselgsnrspslfAMHFPTIPAKVKKLTGAGDCLVGGTVASLSDGLDLIQS 330
Cdd:cd01164 234 ------------------------------------------VYRASPPKVKVVSTVGAGDSMVAGFVAGLAQGLSLEEA 271

                       170
                ....*....|....*.
gi 75306336 331 LAVGIASAKAAVESDD 346
Cdd:cd01164 272 LRLAVAAGSATAFSPG 287
bac_FRK cd01167
Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for ...
 4-327 2.41e-10

Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.


Pssm-ID: 238572 [Multi-domain]  Cd Length: 295  Bit Score: 60.73  E-value: 2.41e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   4 VIIGALILDVHAkpsttpiSGTTVPGQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVL---LKEWKLSMKGIL 80
Cdd:cd01167   3 VCFGEALIDFIP-------EGSGAPETFTKAPGGAPANVAVALARLGGKAAFIGKVGDDEFGDFLletLKEAGVDTRGIQ 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  81 RREDISTPIVSLVYDTNGE-VAAGVAGVDAvENFLTPEWIQRFeynISSARLLMVdanlSSLAL--EASC-------KLA 150
Cdd:cd01167  76 FDPAAPTTLAFVTLDADGErSFEFYRGPAA-DLLLDTELNPDL---LSEADILHF----GSIALasEPSRsallellEAA 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 151 AESSVPVWFEP--------VSVTKSQRIASIAKYVTIVSPNQDELiamanalcaknlfhpfrsdenklsiEDMFRALKP- 221
Cdd:cd01167 148 KKAGVLISFDPnlrpplwrDEEEARERIAELLELADIVKLSDEEL-------------------------ELLFGEEDPe 202

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 222 -AILVLLKNGVKVVIVTLGSNGALLCSKGNPKkalnidrkflrsgevfkrvqsvcspnrfselgsnrspslfamHFPTIP 300
Cdd:cd01167 203 eIAALLLLFGLKLVLVTRGADGALLYTKGGVG------------------------------------------EVPGIP 240

                       330       340
                ....*....|....*....|....*..
gi 75306336 301 AKVKKLTGAGDCLVGGTVASLSDGLDL 327
Cdd:cd01167 241 VEVVDTTGAGDAFVAGLLAQLLSRGLL 267
PRK09954 PRK09954
sugar kinase;
4-255 5.82e-10

sugar kinase;


Pssm-ID: 182165 [Multi-domain]  Cd Length: 362  Bit Score: 60.33  E-value: 5.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336    4 VIIGALILDVHAKPSTTPISGTTVPGQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWKLS---MKGIL 80
Cdd:PRK09954  61 VVVGAINMDIRGMADIRYPQAASHPGTIHCSAGGVGRNIAHNLALLGRDVHLLSAIGDDFYGETLLEETRRAgvnVSGCI 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   81 RREDISTPIVSLVYDTNGEVAAGVAGVDAVENfLTPEWIQRFEYNISSARLLMVDANLSSLALEASCKLAAEssVPVWFE 160
Cdd:PRK09954 141 RLHGQSTSTYLAIANRQDETVLAINDTHILQQ-LTPQLLNGSRDLIRHAGVVLADCNLTAEALEWVFTLADE--IPVFVD 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  161 PVSVTKSQRIASIAKYVTIVSPNQDELIAMANalcaknlfHPFRSDENKLSiedmfralkpAILVLLKNGVKVVIVTLGS 240
Cdd:PRK09954 218 TVSEFKAGKIKHWLAHIHTLKPTQPELEILWG--------QAITSDADRNA----------AVNALHQQGVQQIFVYLPD 279

                        250
                 ....*....|....*
gi 75306336  241 NgALLCSKGNPKKAL 255
Cdd:PRK09954 280 E-SVFCSEKDGEQFL 293
KdgK cd01166
2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form ...
 4-342 1.24e-09

2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.


Pssm-ID: 238571 [Multi-domain]  Cd Length: 294  Bit Score: 58.74  E-value: 1.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   4 VIIGALILDVHAKPSTTPISGttvpGQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKEWK---LSMKGIL 80
Cdd:cd01166   3 VTIGEVMVDLSPPGGGRLEQA----DSFRKFFGGAEANVAVGLARLGHRVALVTAVGDDPFGRFILAELRregVDTSHVR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  81 RREDISTPIV----------SLVYDTNGEvAAGVAGVDAVENFLtpewiqrfeynISSARLLmvdaNLS--SLALEASC- 147
Cdd:cd01166  79 VDPGRPTGLYfleigaggerRVLYYRAGS-AASRLTPEDLDEAA-----------LAGADHL----HLSgiTLALSESAr 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 148 -------KLAAESSVPVWFEPVSVTK-------SQRIASIAKYVTIVSPNQDELIAMANalcaknlfhpfrsDENKLSIE 213
Cdd:cd01166 143 eallealEAAKARGVTVSFDLNYRPKlwsaeeaREALEELLPYVDIVLPSEEEAEALLG-------------DEDPTDAA 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 214 DMFRALKPailvllknGVKVVIVTLGSNGALLCSKGnpkkalnidrkflrsgevfkrvqsvcspnrfselgsnrspslFA 293
Cdd:cd01166 210 ERALALAL--------GVKAVVVKLGAEGALVYTGG------------------------------------------GR 239

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 75306336 294 MHFPTIPAKVKKLTGAGDCLVGGTVASLSDGLDLIQSLAVGIASAKAAV 342
Cdd:cd01166 240 VFVPAYPVEVVDTTGAGDAFAAGFLAGLLEGWDLEEALRFANAAAALVV 288
ribokinase_group_A cd01942
Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ...
 4-344 2.04e-08

Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.


Pssm-ID: 238917 [Multi-domain]  Cd Length: 279  Bit Score: 55.01  E-value: 2.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   4 VIIGALILDV-HAKPSTTPISGTT-VPGQVLfAPGGVARNVADCIFKLGITPFMIGTLGLD---GPANVLLKEWKLSMKG 78
Cdd:cd01942   3 AVVGHLNYDIiLKVESFPGPFESVlVKDLRR-EFGGSAGNTAVALAKLGLSPGLVAAVGEDfhgRLYLEELREEGVDTSH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  79 ILRREDISTP-IVSLVYDTNGEVAAGVAGVDaveNFLTPEWIQRFEYNissARLLmvdanlsSLALEASCKLAAESsVPV 157
Cdd:cd01942  82 VRVVDEDSTGvAFILTDGDDNQIAYFYPGAM---DELEPNDEADPDGL---ADIV-------HLSSGPGLIELARE-LAA 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 158 WFEPVSVTKSQRIAsiaKYVTIVSPNQDEL--IAMANAlcaknlfHPFRSDENKLSIEDMFRALKpailvllkngVKVVI 235
Cdd:cd01942 148 GGITVSFDPGQELP---RLSGEELEEILERadILFVND-------YEAELLKERTGLSEAELASG----------VRVVV 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 236 VTLGSNGALLCSKGNpkkalnidrkflrsgevfkrvqsvcspnrfselgsnrspslfAMHFPTIPA-KVKKLTGAGDCLV 314
Cdd:cd01942 208 VTLGPKGAIVFEDGE------------------------------------------EVEVPAVPAvKVVDTTGAGDAFR 245

                       330       340       350
                ....*....|....*....|....*....|
gi 75306336 315 GGTVASLSDGLDLIQSLAVGIASAKAAVES 344
Cdd:cd01942 246 AGFLYGLLRGYDLEESLRLGNLAASLKVER 275
ribokinase_group_B cd01945
Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ...
 6-342 1.28e-07

Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time. .


Pssm-ID: 238920 [Multi-domain]  Cd Length: 284  Bit Score: 52.68  E-value: 1.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   6 IGALILDVHAKPSTTPIS-GTTVPGQVLFAPGGVARNVADCIFKLGITPFMIGTLGLDGPANVLLKE---WKLSMKGILR 81
Cdd:cd01945   5 VGLAVLDLIYLVASFPGGdGKIVATDYAVIGGGNAANAAVAVARLGGQARLIGVVGDDAIGRLILAElaaEGVDTSFIVV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  82 REDISTPIVSLVYDTNGEvaagvaGVDAVENFLTPEWIQRF-EYNISSARLLMVDANLSSLALEASCKL-AAESSVPVWF 159
Cdd:cd01945  85 APGARSPISSITDITGDR------ATISITAIDTQAAPDSLpDAILGGADAVLVDGRQPEAALHLAQEArARGIPIPLDL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 160 EPVSVTKSQRIASIAKYvtivspnqdeliamanALCAKNLFHPfrsdeNKLSIEDMFralkpaiLVLLKN-GVKVVIVTL 238
Cdd:cd01945 159 DGGGLRVLEELLPLADH----------------AICSENFLRP-----NTGSADDEA-------LELLASlGIPFVAVTL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 239 GSNGALLCSkgnpkkalnidrkflRSGEVFkrvqsvcspnrfselgsnrspslfamHFPTIPAKVKKLTGAGDCLVGGTV 318
Cdd:cd01945 211 GEAGCLWLE---------------RDGELF--------------------------HVPAFPVEVVDTTGAGDVFHGAFA 249

                       330       340
                ....*....|....*....|....
gi 75306336 319 ASLSDGLDLIQSLAvgIASAKAAV 342
Cdd:cd01945 250 HALAEGMPLREALR--FASAAAAL 271
ribokinase_pfkB_like cd00287
ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including ...
 4-321 1.70e-05

ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-dehydro-3-deoxygluconokinase, 1-phosphofructokinase, the minor 6-phosphofructokinase (PfkB), inosine-guanosine kinase, and adenosine kinase. Even though there is a high degree of structural conservation within this superfamily, their multimerization level varies widely, monomeric (e.g. adenosine kinase), dimeric (e.g. ribokinase), and trimeric (e.g THZ kinase).


Pssm-ID: 238177 [Multi-domain]  Cd Length: 196  Bit Score: 45.16  E-value: 1.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   4 VIIGALILDVHAKPSTTPISGTTV-PGQVLFAPGGVARNVADCIFKLGITPFMIGtlgldgpanvllkewklsmkgilrr 82
Cdd:cd00287   3 LVVGSLLVDVILRVDALPLPGGLVrPGDTEERAGGGAANVAVALARLGVSVTLVG------------------------- 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  83 edistpiVSLVYdTNGEVAAGVAGVDAVEnfltpewiqrfeynissarllmvdanlsslaleasckLAAESSVPVWFEPV 162
Cdd:cd00287  58 -------ADAVV-ISGLSPAPEAVLDALE-------------------------------------EARRRGVPVVLDPG 92

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 163 SVTKSQRIASIAK---YVTIVSPNQDELIAMANAlcaknlfhpfRSDENKLSIEDMFRalkpailvLLKNGVKVVIVTLG 239
Cdd:cd00287  93 PRAVRLDGEELEKllpGVDILTPNEEEAEALTGR----------RDLEVKEAAEAAAL--------LLSKGPKVVIVTLG 154

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 240 SNGALLCSKGNPkkalnidrkflrsgevfkrvqsvcspnrfselgsnrspslfAMHFPTIPAKVKKLTGAGDCLVGGTVA 319
Cdd:cd00287 155 EKGAIVATRGGT-----------------------------------------EVHVPAFPVKVVDTTGAGDAFLAALAA 193


                ..
gi 75306336 320 SL 321
Cdd:cd00287 194 GL 195
RfaE_like cd01172
RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the ...
 4-342 1.68e-04

RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer membrane of gram-negative bacteria. RfaE consists of two domains, a sugar kinase domain, represented here, and a domain belonging to the cytidylyltransferase superfamily.


Pssm-ID: 238577 [Multi-domain]  Cd Length: 304  Bit Score: 42.93  E-value: 1.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336   4 VIIGALILD--VHAKPS----TTPISGTTVPGQVLFaPGG---VARNVADcifkLGITPFMIGTLGLDGPANVLLKewKL 74
Cdd:cd01172   3 LVVGDVILDeyLYGDVErispEAPVPVVKVEREEIR-LGGaanVANNLAS----LGAKVTLLGVVGDDEAGDLLRK--LL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336  75 SMKGI----LRREDISTPIVSLVYDTNGEVAAgvagVD-----AVENFLTPEWIQRFEYNISSARLLMV-DAN---LSSL 141
Cdd:cd01172  76 EKEGIdtdgIVDEGRPTTTKTRVIARNQQLLR----VDreddsPLSAEEEQRLIERIAERLPEADVVILsDYGkgvLTPR 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 142 ALEASCKLAAESSVPVwfepvsVTKSQRiASIAKY--VTIVSPNQDEL-IAMANALCaknlfhpfrsdeNKLSIEDMFRA 218
Cdd:cd01172 152 VIEALIAAARELGIPV------LVDPKG-RDYSKYrgATLLTPNEKEArEALGDEIN------------DDDELEAAGEK 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75306336 219 LKPailvllKNGVKVVIVTLGSNGALLcskgnpkkalnidrkFLRSGEVfkrvqsvcspnrfselgsnrspslfaMHFPT 298
Cdd:cd01172 213 LLE------LLNLEALLVTLGEEGMTL---------------FERDGEV--------------------------QHIPA 245

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 75306336 299 IPAKVKKLTGAGDCLVGGTVASLSDGLDLIQSLAvgIASAKAAV 342
Cdd:cd01172 246 LAKEVYDVTGAGDTVIATLALALAAGADLEEAAF--LANAAAGV 287
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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