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Conserved domains on  [gi|74822503|sp|Q966W3|]
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RecName: Full=Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; AltName: Full=Glucosaminyl N-deacetylase/N-sulfotransferase 1; Includes: RecName: Full=Heparan sulfate N-deacetylase 1; Includes: RecName: Full=Heparan sulfate N-sulfotransferase 1

Protein Classification

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase; sulfotransferase family protein( domain architecture ID 10572470)

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate| sulfotransferase family protein may catalyze the transfer of sulfate from a donor such as 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 74-491 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


:

Pssm-ID: 463450  Cd Length: 429  Bit Score: 756.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503    74 TDARILVILDSLFSRHGKTIIQILNSQKLQFKAEAVSKNLPVLTTSRRGRYSLIIIENYYKYLNMAQWNRQLLDKYCKEY 153
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIAKKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCREY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   154 RVPMFSFmSSKPNDQLKRIKIKGSSLWMWQNQRIQRLAVTP-SIIHRISKIGNYRQFSSSDPaDWILFET-SEKFESVLS 231
Cdd:pfam12062  81 GVGIIGF-FKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPkSPLLRITRPGEVEQGPLPGD-DWTVFQSnHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   232 GTVKSGYE----------RAVVVRDKGLEDGVERIIFGRNLTDFQVKITFLDALWWAMGNQKSFTLDRFVQVDIDDVFVG 301
Cdd:pfam12062 159 AKVKSGEEspspgldaalLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   302 AQGTRIVEEDVRKLISTQKEFRNYVQNFTFMLGFSGSYFRNGDDLEDRGDEFLVENAEKFVWFPHMWRHNHAH-EHNFTY 380
Cdd:pfam12062 239 KEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHlFHNQTV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   381 LEAIMAQNKLFAQNMHLPVDYPYAIAPQHDGVFPVHEQLFRAWRKVWNVSVTATEEYPHFKPATARKGFIHAGIHVLPRQ 460
Cdd:pfam12062 319 LEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQ 398

                         410       420       430
                  ....*....|....*....|....*....|.
gi 74822503   461 TCGLYTHTQLFDEYPEGFDKVQKSIEGGDLF 491
Cdd:pfam12062 399 TCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 super family cl21551
Sulfotransferase domain;
582-822 9.93e-26

Sulfotransferase domain;


The actual alignment was detected with superfamily member pfam00685:

Pssm-ID: 473908 [Multi-domain]  Cd Length: 253  Bit Score: 107.04  E-value: 9.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   582 LPDLLIIGPQKTGSTALASFLSLHPNTSQNTPvpgsFEEVQFFGGQNYLKGVEWYMSNFPSSSTVTFEKSA--------- 652
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEK----SEEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNalpspriik 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   653 TYFDNPSAPKQAASlvPHAKIVIILQNPAQRAYSWFQHILAHEDPVAITAGSLEVildsnstssKKVRQRCISGGRYVHH 732
Cdd:pfam00685  77 THLPLHLLPKSLWD--PNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV---------EDFLNGKVNCGSYFDH 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   733 LTKWLEHFSLQQMIFVDSDELKMKPPTVLNSLSKWLDLP--EFPFETYIRYS---PSKGFHC----RLLD----GKTKCL 799
Cdd:pfam00685 146 VKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPltEEELDKIVKHLsfeNMKGNPClnysKLPKevspFFRKGL 225

                         250       260
                  ....*....|....*....|...
gi 74822503   800 GESkgrKYPEMPENLRRKLDKIF 822
Cdd:pfam00685 226 VGD---WKNYFTPEQAEKFDEIY 245
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 74-491 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 756.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503    74 TDARILVILDSLFSRHGKTIIQILNSQKLQFKAEAVSKNLPVLTTSRRGRYSLIIIENYYKYLNMAQWNRQLLDKYCKEY 153
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIAKKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCREY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   154 RVPMFSFmSSKPNDQLKRIKIKGSSLWMWQNQRIQRLAVTP-SIIHRISKIGNYRQFSSSDPaDWILFET-SEKFESVLS 231
Cdd:pfam12062  81 GVGIIGF-FKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPkSPLLRITRPGEVEQGPLPGD-DWTVFQSnHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   232 GTVKSGYE----------RAVVVRDKGLEDGVERIIFGRNLTDFQVKITFLDALWWAMGNQKSFTLDRFVQVDIDDVFVG 301
Cdd:pfam12062 159 AKVKSGEEspspgldaalLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   302 AQGTRIVEEDVRKLISTQKEFRNYVQNFTFMLGFSGSYFRNGDDLEDRGDEFLVENAEKFVWFPHMWRHNHAH-EHNFTY 380
Cdd:pfam12062 239 KEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHlFHNQTV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   381 LEAIMAQNKLFAQNMHLPVDYPYAIAPQHDGVFPVHEQLFRAWRKVWNVSVTATEEYPHFKPATARKGFIHAGIHVLPRQ 460
Cdd:pfam12062 319 LEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQ 398

                         410       420       430
                  ....*....|....*....|....*....|.
gi 74822503   461 TCGLYTHTQLFDEYPEGFDKVQKSIEGGDLF 491
Cdd:pfam12062 399 TCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
582-822 9.93e-26

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 107.04  E-value: 9.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   582 LPDLLIIGPQKTGSTALASFLSLHPNTSQNTPvpgsFEEVQFFGGQNYLKGVEWYMSNFPSSSTVTFEKSA--------- 652
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEK----SEEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNalpspriik 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   653 TYFDNPSAPKQAASlvPHAKIVIILQNPAQRAYSWFQHILAHEDPVAITAGSLEVildsnstssKKVRQRCISGGRYVHH 732
Cdd:pfam00685  77 THLPLHLLPKSLWD--PNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV---------EDFLNGKVNCGSYFDH 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   733 LTKWLEHFSLQQMIFVDSDELKMKPPTVLNSLSKWLDLP--EFPFETYIRYS---PSKGFHC----RLLD----GKTKCL 799
Cdd:pfam00685 146 VKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPltEEELDKIVKHLsfeNMKGNPClnysKLPKevspFFRKGL 225

                         250       260
                  ....*....|....*....|...
gi 74822503   800 GESkgrKYPEMPENLRRKLDKIF 822
Cdd:pfam00685 226 VGD---WKNYFTPEQAEKFDEIY 245
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 74-491 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 756.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503    74 TDARILVILDSLFSRHGKTIIQILNSQKLQFKAEAVSKNLPVLTTSRRGRYSLIIIENYYKYLNMAQWNRQLLDKYCKEY 153
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIAKKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCREY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   154 RVPMFSFmSSKPNDQLKRIKIKGSSLWMWQNQRIQRLAVTP-SIIHRISKIGNYRQFSSSDPaDWILFET-SEKFESVLS 231
Cdd:pfam12062  81 GVGIIGF-FKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPkSPLLRITRPGEVEQGPLPGD-DWTVFQSnHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   232 GTVKSGYE----------RAVVVRDKGLEDGVERIIFGRNLTDFQVKITFLDALWWAMGNQKSFTLDRFVQVDIDDVFVG 301
Cdd:pfam12062 159 AKVKSGEEspspgldaalLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   302 AQGTRIVEEDVRKLISTQKEFRNYVQNFTFMLGFSGSYFRNGDDLEDRGDEFLVENAEKFVWFPHMWRHNHAH-EHNFTY 380
Cdd:pfam12062 239 KEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHlFHNQTV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   381 LEAIMAQNKLFAQNMHLPVDYPYAIAPQHDGVFPVHEQLFRAWRKVWNVSVTATEEYPHFKPATARKGFIHAGIHVLPRQ 460
Cdd:pfam12062 319 LEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQ 398

                         410       420       430
                  ....*....|....*....|....*....|.
gi 74822503   461 TCGLYTHTQLFDEYPEGFDKVQKSIEGGDLF 491
Cdd:pfam12062 399 TCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
582-822 9.93e-26

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 107.04  E-value: 9.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   582 LPDLLIIGPQKTGSTALASFLSLHPNTSQNTPvpgsFEEVQFFGGQNYLKGVEWYMSNFPSSSTVTFEKSA--------- 652
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEK----SEEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNalpspriik 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   653 TYFDNPSAPKQAASlvPHAKIVIILQNPAQRAYSWFQHILAHEDPVAITAGSLEVildsnstssKKVRQRCISGGRYVHH 732
Cdd:pfam00685  77 THLPLHLLPKSLWD--PNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV---------EDFLNGKVNCGSYFDH 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   733 LTKWLEHFSLQQMIFVDSDELKMKPPTVLNSLSKWLDLP--EFPFETYIRYS---PSKGFHC----RLLD----GKTKCL 799
Cdd:pfam00685 146 VKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPltEEELDKIVKHLsfeNMKGNPClnysKLPKevspFFRKGL 225

                         250       260
                  ....*....|....*....|...
gi 74822503   800 GESkgrKYPEMPENLRRKLDKIF 822
Cdd:pfam00685 226 VGD---WKNYFTPEQAEKFDEIY 245
Sulfotransfer_3 pfam13469
Sulfotransferase family;
585-771 7.41e-06

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 47.29  E-value: 7.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   585 LLIIGPQKTGSTALASFLSLHpntsqntPVPGSFEEVQFFGGQNYLKGVEWY-----MSNFPSSSTVTFEKSATYFDNPS 659
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAH-------PDVRPPEETWFVIPRILALLQAWGksleaLARVPSYARWLCDKSPSHLFHLD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74822503   660 APKQAaslVPHAKIVIILQNPAQRAYSWFQHILAHedpvaitagslevilDSNSTSSKKVRQRCISGGRYVHHLTKWLEH 739
Cdd:pfam13469  74 LLLKA---FPDAKFIHLHRDPVDTVISSYCSLFGF---------------TLSSYSTAFLRDIGLALARWSRAYERLMAA 135

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 74822503   740 ---FSLQQMIFVDSDELKMKPPTVLNSLSKWLDLP 771
Cdd:pfam13469 136 rarVPPGRFLDVRYEDLVADPEGTLRRILEFLGLP 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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