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Conserved domains on  [gi|41016916|sp|Q969X6|]
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RecName: Full=U3 small nucleolar RNA-associated protein 4 homolog; AltName: Full=Cirhin; AltName: Full=UTP4 small subunit processome component

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-306 4.82e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 4.82e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916   7 HRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRATeALCW-AEGQRLFSAGLNGEIME 85
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVT-SVAFsPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  86 YDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQfeRNFDRQKSRILSLSWHPSGTHIAAGSI 165
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 166 D-YISVFDVKSGSAVHKmivdrqymgVSKRKCIVWGVAFLSDG-TIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIA 243
Cdd:COG2319 267 DgTVRLWDLATGELLRT---------LTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41016916 244 VADQEDSFVVGTAEGTVfhfQLVPVTSNSsekqwvRTKPFQHHTHDVRTVAHSP--TALISGGTD 306
Cdd:COG2319 338 FSPDGKTLASGSDDGTV---RLWDLATGE------LLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 286-547 9.66e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 9.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 286 HTHDVRTVAHSPTA--LISGGTDTHL----VFRPLMEKVEVKNYDAALRKITFPH-RCLISCSKKRQLLLfqfahhlelW 358
Cdd:cd00200   8 HTGGVTCVAFSPDGklLATGSGDGTIkvwdLETGELLRTLKGHTGPVRDVAASADgTYLASGSSDKTIRL---------W 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 359 RLGstvaTGKNGDTLplsknADHLlhlktkgpENIICSCISPCGSWIAYSTVSRFFlyRLnyeHDNISLKRVSKMPAFLR 438
Cdd:cd00200  79 DLE----TGECVRTL-----TGHT--------SYVSSVAFSPDGRILSSSSRDKTI--KV---WDVETGKCLTTLRGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 439 SALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLhaFQPQSGTVEAMCllaVSPDGNWLAASGTSAGVHVYNVKQLKL 518
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT--LTGHTGEVNSVA---FSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                       250       260
                ....*....|....*....|....*....
gi 41016916 519 HCTVPAYNFPVTAMAIAPNTNNLVIAHSD 547
Cdd:cd00200 212 LGTLRGHENGVNSVAFSPDGYLLASGSED 240
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-306 4.82e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 4.82e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916   7 HRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRATeALCW-AEGQRLFSAGLNGEIME 85
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVT-SVAFsPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  86 YDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQfeRNFDRQKSRILSLSWHPSGTHIAAGSI 165
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 166 D-YISVFDVKSGSAVHKmivdrqymgVSKRKCIVWGVAFLSDG-TIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIA 243
Cdd:COG2319 267 DgTVRLWDLATGELLRT---------LTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41016916 244 VADQEDSFVVGTAEGTVfhfQLVPVTSNSsekqwvRTKPFQHHTHDVRTVAHSP--TALISGGTD 306
Cdd:COG2319 338 FSPDGKTLASGSDDGTV---RLWDLATGE------LLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-306 8.93e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 8.93e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  16 PSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANyFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKY 95
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  96 AMDAFGGPIWSMAASPSGsQLLVGC-EDGSVKLFQITPDKIQFErnFDRQKSRILSLSWHPSGTHIAAGSID-YISVFDV 173
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDG-RILSSSsRDKTIKVWDVETGKCLTT--LRGHTDWVNSVAFSPDGTFVASSSQDgTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 174 KSGSAVHkmivdrQYMGvskRKCIVWGVAFLSDG-TIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFV 252
Cdd:cd00200 165 RTGKCVA------TLTG---HTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41016916 253 VGTAEGTVFHFQLvpvtsnsseKQWVRTKPFQHHTHDVRTVAHSPTA--LISGGTD 306
Cdd:cd00200 236 SGSEDGTIRVWDL---------RTGECVQTLSGHTNSVTSLAWSPDGkrLASGSAD 282
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 107-202 2.13e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 46.12  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916   107 MAASPSGSQLLVGCEDGSVKLFQITPDKIqFERNFDRQKSRILSLSWHPSGTHIAAGSID-YISVFDVKSGSAVHKMIVd 185
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRV-WTLSPDKEDLEVTSLAWRPDGKLLAVGYSDgTVRLLDAENGKIVHHFSA- 78

                          90
                  ....*....|....*..
gi 41016916   186 rqymGVSKRKCIVWGVA 202
Cdd:pfam12894  79 ----GSDLITCLGWGEN 91
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 286-547 9.66e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 9.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 286 HTHDVRTVAHSPTA--LISGGTDTHL----VFRPLMEKVEVKNYDAALRKITFPH-RCLISCSKKRQLLLfqfahhlelW 358
Cdd:cd00200   8 HTGGVTCVAFSPDGklLATGSGDGTIkvwdLETGELLRTLKGHTGPVRDVAASADgTYLASGSSDKTIRL---------W 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 359 RLGstvaTGKNGDTLplsknADHLlhlktkgpENIICSCISPCGSWIAYSTVSRFFlyRLnyeHDNISLKRVSKMPAFLR 438
Cdd:cd00200  79 DLE----TGECVRTL-----TGHT--------SYVSSVAFSPDGRILSSSSRDKTI--KV---WDVETGKCLTTLRGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 439 SALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLhaFQPQSGTVEAMCllaVSPDGNWLAASGTSAGVHVYNVKQLKL 518
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT--LTGHTGEVNSVA---FSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                       250       260
                ....*....|....*....|....*....
gi 41016916 519 HCTVPAYNFPVTAMAIAPNTNNLVIAHSD 547
Cdd:cd00200 212 LGTLRGHENGVNSVAFSPDGYLLASGSED 240
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
434-544 6.08e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 6.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 434 PAFLRSALQILFSEDSTKLFVA-SNQGALHIVQLSGGsfKHLHAFQPQSGTVEamclLAVSPDGNWL-AASGTSAGVHVY 511
Cdd:COG3391  64 AAAVADADGADAGADGRRLYVAnSGSGRVSVIDLATG--KVVATIPVGGGPRG----LAVDPDGGRLyVADSGNGRVSVI 137

                        90       100       110
                ....*....|....*....|....*....|...
gi 41016916 512 NVKQLKLHCTVPAYNFPvTAMAIAPNTNNLVIA 544
Cdd:COG3391 138 DTATGKVVATIPVGAGP-HGIAVDPDGKRLYVA 169
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-128 4.38e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 4.38e-03
                           10        20
                   ....*....|....*....|....*..
gi 41016916    102 GPIWSMAASPSGSQLLVGCEDGSVKLF 128
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-306 4.82e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 4.82e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916   7 HRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRATeALCW-AEGQRLFSAGLNGEIME 85
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVT-SVAFsPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  86 YDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQfeRNFDRQKSRILSLSWHPSGTHIAAGSI 165
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 166 D-YISVFDVKSGSAVHKmivdrqymgVSKRKCIVWGVAFLSDG-TIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIA 243
Cdd:COG2319 267 DgTVRLWDLATGELLRT---------LTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41016916 244 VADQEDSFVVGTAEGTVfhfQLVPVTSNSsekqwvRTKPFQHHTHDVRTVAHSP--TALISGGTD 306
Cdd:COG2319 338 FSPDGKTLASGSDDGTV---RLWDLATGE------LLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
WD40 COG2319
WD40 repeat [General function prediction only];
17-260 4.83e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 4.83e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  17 SGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYfQEKFFPGHESRATeALCWA-EGQRLFSAGLNGEIMEYDLQALNIKY 95
Cdd:COG2319 163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVR-SVAFSpDGKLLASGSADGTVRLWDLATGKLLR 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  96 AMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQfeRNFDRQKSRILSLSWHPSGTHIAAGSIDY-ISVFDVK 174
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA 318

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 175 SGSAVHkmivdrqymGVSKRKCIVWGVAFLSDG-TIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVV 253
Cdd:COG2319 319 TGKLLR---------TLTGHTGAVRSVAFSPDGkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389


                ....*..
gi 41016916 254 GTAEGTV 260
Cdd:COG2319 390 GSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-306 8.93e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 8.93e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  16 PSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANyFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKY 95
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  96 AMDAFGGPIWSMAASPSGsQLLVGC-EDGSVKLFQITPDKIQFErnFDRQKSRILSLSWHPSGTHIAAGSID-YISVFDV 173
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDG-RILSSSsRDKTIKVWDVETGKCLTT--LRGHTDWVNSVAFSPDGTFVASSSQDgTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 174 KSGSAVHkmivdrQYMGvskRKCIVWGVAFLSDG-TIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFV 252
Cdd:cd00200 165 RTGKCVA------TLTG---HTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41016916 253 VGTAEGTVFHFQLvpvtsnsseKQWVRTKPFQHHTHDVRTVAHSPTA--LISGGTD 306
Cdd:cd00200 236 SGSEDGTIRVWDL---------RTGECVQTLSGHTNSVTSLAWSPDGkrLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
16-406 3.63e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 3.63e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  16 PSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYfQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKY 95
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA-LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  96 AMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQfeRNFDRQKSRILSLSWHPSGTHIAAGSIDY-ISVFDVK 174
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL--RTLTGHSGAVTSVAFSPDGKLLASGSDDGtVRLWDLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 175 SGSAVHKMIVDRQYmgvskrkciVWGVAFLSDG-TIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVV 253
Cdd:COG2319 193 TGKLLRTLTGHTGA---------VRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 254 GTAEGTVFHFQLvpvtsnsSEKQWVRTkpFQHHTHDVRTVAHSP--TALISGGTDTHLvfrplmeKVevknYDAALRKIT 331
Cdd:COG2319 264 GSADGTVRLWDL-------ATGELLRT--LTGHSGGVNSVAFSPdgKLLASGSDDGTV-------RL----WDLATGKLL 323

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 332 FPHRcliscskkrqlllfqfAHHLELWRL-----GSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICS-CISPCGSWI 405
Cdd:COG2319 324 RTLT----------------GHTGAVRSVafspdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSvAFSPDGRTL 387


                .
gi 41016916 406 A 406
Cdd:COG2319 388 A 388
WD40 COG2319
WD40 repeat [General function prediction only];
55-550 4.80e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 4.80e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  55 FPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDK 134
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 135 IQfeRNFDRQKSRILSLSWHPSGTHIAAGSIDY-ISVFDVKSGSAVhkmivdRQYMGVSKRkciVWGVAFLSDG-TIISV 212
Cdd:COG2319 112 LL--RTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLATGKLL------RTLTGHSGA---VTSVAFSPDGkLLASG 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 213 DSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVfhfQLVPVTSNssekQWVRTkpFQHHTHDVRT 292
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV---RLWDLATG----KLLRT--LTGHSGSVRS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 293 VAHSP--TALISGGTDthlvfrplmekvevknydaalrkitfphrcliscskkrqlllfqfaHHLELWRlgstVATGKNG 370
Cdd:COG2319 252 VAFSPdgRLLASGSAD----------------------------------------------GTVRLWD----LATGELL 281

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 371 DTLplsknadhllhlktKGPENIICScispcgswiaystvsrfflyrlnyehdnislkrvskmpaflrsalqILFSEDST 450
Cdd:COG2319 282 RTL--------------TGHSGGVNS----------------------------------------------VAFSPDGK 301

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 451 KLFVASNQGALHIVQLSGGsfKHLHAFQPQSGTVEAmclLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVT 530
Cdd:COG2319 302 LLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                       490       500
                ....*....|....*....|
gi 41016916 531 AMAIAPNTNNLVIAHSDQQV 550
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
16-225 2.66e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 2.66e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  16 PSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANyFQEKFFPGHESRATeALCWA-EGQRLFSAGLNGEIMEYDLQALNIK 94
Cdd:COG2319 204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVR-SVAFSpDGRLLASGSADGTVRLWDLATGELL 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  95 YAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQfeRNFDRQKSRILSLSWHPSGTHIAAGSID-YISVFDV 173
Cdd:COG2319 282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDgTVRLWDL 359

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 41016916 174 KSGSAVHKmivdrqYMGVSKRkciVWGVAFLSDG-TIISVDSAGKVQFWDSAT 225
Cdd:COG2319 360 ATGELLRT------LTGHTGA---VTSVAFSPDGrTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-222 9.89e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.31  E-value: 9.89e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  17 SGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRATeALCWAE-GQRLFSAGLNGEIMEYDLQALNIKY 95
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVN-SVAFSPdGTFVASSSQDGTIKLWDLRTGKCVA 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  96 AMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQItpDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDY-ISVFDVK 174
Cdd:cd00200 172 TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL--STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGtIRVWDLR 249

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 41016916 175 SGSaVHKMIVdrqymGVSKRkciVWGVAFLSDG-TIISVDSAGKVQFWD 222
Cdd:cd00200 250 TGE-CVQTLS-----GHTNS---VTSLAWSPDGkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-131 5.92e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 5.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916   8 RVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLsANYFQEKFFPGHESRATeALCW-AEGQRLFSAGLNGEIMEY 86
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVR-SVAFsPDGKTLASGSDDGTVRLW 357

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 41016916  87 DLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQIT 131
Cdd:COG2319 358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-550 2.86e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 2.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 102 GPIWSMAASPSGSQLLVGCEDGSVKLFQITPDkiQFERNFDRQKSRILSLSWHPSGTHIAAGSIDY-ISVFDVKSGSAVH 180
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 181 KMIVDRQYmgvskrkciVWGVAFLSDGTIISVDSA-GKVQFWDSATGTLVKShlianadvqsiavadqedsfvvgtaegt 259
Cdd:cd00200  88 TLTGHTSY---------VSSVAFSPDGRILSSSSRdKTIKVWDVETGKCLTT---------------------------- 130

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 260 vfhfqlvpvtsnssekqwvrtkpFQHHTHDVRTVAHSPT-ALISGGTDTHLVFrplmekvevknydaalrkitfphrcli 338
Cdd:cd00200 131 -----------------------LRGHTDWVNSVAFSPDgTFVASSSQDGTIK--------------------------- 160

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 339 scskkrqlllfqfahhleLWRLgstvATGKNGDTLplsknadhllhlktKGPENIICSCIspcgswiaystvsrfflyrl 418
Cdd:cd00200 161 ------------------LWDL----RTGKCVATL--------------TGHTGEVNSVA-------------------- 184

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 419 nyehdnislkrvskmpaflrsalqilFSEDSTKLFVASNQGALHIVQLSGGsfKHLHAFQPQSGTVEAmclLAVSPDGNW 498
Cdd:cd00200 185 --------------------------FSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLRGHENGVNS---VAFSPDGYL 233

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 41016916 499 LAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQV 550
Cdd:cd00200 234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 107-202 2.13e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 46.12  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916   107 MAASPSGSQLLVGCEDGSVKLFQITPDKIqFERNFDRQKSRILSLSWHPSGTHIAAGSID-YISVFDVKSGSAVHKMIVd 185
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRV-WTLSPDKEDLEVTSLAWRPDGKLLAVGYSDgTVRLLDAENGKIVHHFSA- 78

                          90
                  ....*....|....*..
gi 41016916   186 rqymGVSKRKCIVWGVA 202
Cdd:pfam12894  79 ----GSDLITCLGWGEN 91
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 286-547 9.66e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 9.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 286 HTHDVRTVAHSPTA--LISGGTDTHL----VFRPLMEKVEVKNYDAALRKITFPH-RCLISCSKKRQLLLfqfahhlelW 358
Cdd:cd00200   8 HTGGVTCVAFSPDGklLATGSGDGTIkvwdLETGELLRTLKGHTGPVRDVAASADgTYLASGSSDKTIRL---------W 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 359 RLGstvaTGKNGDTLplsknADHLlhlktkgpENIICSCISPCGSWIAYSTVSRFFlyRLnyeHDNISLKRVSKMPAFLR 438
Cdd:cd00200  79 DLE----TGECVRTL-----TGHT--------SYVSSVAFSPDGRILSSSSRDKTI--KV---WDVETGKCLTTLRGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 439 SALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLhaFQPQSGTVEAMCllaVSPDGNWLAASGTSAGVHVYNVKQLKL 518
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT--LTGHTGEVNSVA---FSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                       250       260
                ....*....|....*....|....*....
gi 41016916 519 HCTVPAYNFPVTAMAIAPNTNNLVIAHSD 547
Cdd:cd00200 212 LGTLRGHENGVNSVAFSPDGYLLASGSED 240
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
434-544 6.08e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 6.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 434 PAFLRSALQILFSEDSTKLFVA-SNQGALHIVQLSGGsfKHLHAFQPQSGTVEamclLAVSPDGNWL-AASGTSAGVHVY 511
Cdd:COG3391  64 AAAVADADGADAGADGRRLYVAnSGSGRVSVIDLATG--KVVATIPVGGGPRG----LAVDPDGGRLyVADSGNGRVSVI 137

                        90       100       110
                ....*....|....*....|....*....|...
gi 41016916 512 NVKQLKLHCTVPAYNFPvTAMAIAPNTNNLVIA 544
Cdd:COG3391 138 DTATGKVVATIPVGAGP-HGIAVDPDGKRLYVA 169
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
10-226 3.20e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 3.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  10 RFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLF-SAGLNGEIMEYDL 88
Cdd:COG3391  18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYvANSGSGRVSVIDL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916  89 QALNIKYAMDAFGGPiWSMAASPSGSQLLVGCEDGSvKLFQITPDKIQFERNFDRQKSrILSLSWHPSGTHIAAGSID-- 166
Cdd:COG3391  98 ATGKVVATIPVGGGP-RGLAVDPDGGRLYVADSGNG-RVSVIDTATGKVVATIPVGAG-PHGIAVDPDGKRLYVANSGsn 174

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41016916 167 ----YISVFDVKSGSAVHKMIVDRQymgvskrkciVWGVAFLSDGTII---------SVDSAGKVQFWDSATG 226
Cdd:COG3391 175 tvsvIVSVIDTATGKVVATIPVGGG----------PVGVAVSPDGRRLyvanrgsntSNGGSNTVSVIDLATL 237
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 445-590 4.09e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 4.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 445 FSEDSTKLFVASNQGALHIVQLSGGSFkhLHAFQPQSGTVEAmclLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPA 524
Cdd:cd00200  17 FSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRD---VAASADGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41016916 525 YNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYtdwsrtVQKQGFHHLWlqrdtpITHISFHP 590
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC------LTTLRGHTDW------VNSVAFSP 145
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-128 4.38e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 4.38e-03
                           10        20
                   ....*....|....*....|....*..
gi 41016916    102 GPIWSMAASPSGSQLLVGCEDGSVKLF 128
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLW 39
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 387-507 4.64e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.50  E-value: 4.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 387 TKGPENIICSCISPCGSWIAYSTVS--RFFLYRLNYEHDNIslKRVSKMPAFLRSALqilFSEDSTKLFVASNQG---AL 461
Cdd:COG0823  27 TNSPGIDTSPAWSPDGRRIAFTSDRggGPQIYVVDADGGEP--RRLTFGGGYNASPS---WSPDGKRLAFVSRSDgrfDI 101

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 41016916 462 HIVQLSGGSFKHL--HAFQPqsgtveamcllAVSPDGNWLAASGTSAG 507
Cdd:COG0823 102 YVLDLDGGAPRRLtdGPGSP-----------SWSPDGRRIVFSSDRGG 138
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 103-184 9.94e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 38.75  E-value: 9.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41016916 103 PIWSMAASPSGSQLLVGceDGSVKLFQitpdkiqfernFD-RQK-----------SRILSLSWHPSGTHIAAGSID-YIS 169
Cdd:cd22857 225 PIKAVAEDPDGHTVYVG--DTSGDLAS-----------IDlRTGkllgcfkgkcgGSIRSIARHPELPLIASCGLDrYLR 291

                        90
                ....*....|....*
gi 41016916 170 VFDVKSGSAVHKMIV 184
Cdd:cd22857 292 IWDTETRQLLSKVYL 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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