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Conserved domains on  [gi|311033512|sp|Q96A28|]
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RecName: Full=SLAM family member 9; AltName: Full=CD2 family member 10; Short=CD2F-10; AltName: Full=CD84 homolog 1; Short=CD84-H1; Flags: Precursor

Protein Classification

Ig_SLAM-CD84_like_N domain-containing protein( domain architecture ID 11617245)

Ig_SLAM-CD84_like_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 29-130 1.50e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 125.90  E-value: 1.50e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033512  29 EVVAVLQESISLPLEIPPDEEVENIIWSSHKSLATVVPGKEGHPaTIMVTNPHYQGQVSFLDPSYSLHISNLSWEDSGLY 108
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAP-EIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 311033512 109 QAQVNLRTSQISTMQQYNICVY 130
Cdd:cd16842   81 RARINTKNSRVTITKEFTLHIY 102
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 29-130 1.50e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 125.90  E-value: 1.50e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033512  29 EVVAVLQESISLPLEIPPDEEVENIIWSSHKSLATVVPGKEGHPaTIMVTNPHYQGQVSFLDPSYSLHISNLSWEDSGLY 108
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAP-EIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 311033512 109 QAQVNLRTSQISTMQQYNICVY 130
Cdd:cd16842   81 RARINTKNSRVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 26-113 2.24e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.75  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033512   26 GSEEVVAVLQESISLPLEIPPDEEVEN--IIWSshKSLATVVPGKEGHPATIMVTNPHYQGQVSFLDP----SYSLHISN 99
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAStsVYWY--RQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDpsngDGSLTIQN 79

                          90
                  ....*....|....
gi 311033512  100 LSWEDSGLYQAQVN 113
Cdd:pfam07686  80 LTLSDSGTYTCAVI 93
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 29-130 1.50e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 125.90  E-value: 1.50e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033512  29 EVVAVLQESISLPLEIPPDEEVENIIWSSHKSLATVVPGKEGHPaTIMVTNPHYQGQVSFLDPSYSLHISNLSWEDSGLY 108
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAP-EIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 311033512 109 QAQVNLRTSQISTMQQYNICVY 130
Cdd:cd16842   81 RARINTKNSRVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 26-113 2.24e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.75  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033512   26 GSEEVVAVLQESISLPLEIPPDEEVEN--IIWSshKSLATVVPGKEGHPATIMVTNPHYQGQVSFLDP----SYSLHISN 99
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAStsVYWY--RQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDpsngDGSLTIQN 79

                          90
                  ....*....|....
gi 311033512  100 LSWEDSGLYQAQVN 113
Cdd:pfam07686  80 LTLSDSGTYTCAVI 93
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 28-108 7.36e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 38.58  E-value: 7.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033512  28 EEVVAVLQESISLPLEIPP--DEEVENIIW-----SSHKSLATVvpgkegHPATIMVTNPHYQGQVSFLDPSY-----SL 95
Cdd:cd05718    7 TEVTGFLGGSVTLPCSLTSpgTTKITQVTWmkigaGSSQNVAVF------HPQYGPSVPNPYAERVEFLAARLglrnaTL 80

                         90
                 ....*....|...
gi 311033512  96 HISNLSWEDSGLY 108
Cdd:cd05718   81 RIRNLRVEDEGNY 93
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 27-109 4.29e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 35.79  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033512  27 SEEVVAVLQESISLPLEIPPDEEVEnIIWSSHKSL-ATVVPGKEghpatIMVTNPhYQGQVSFLDPSYSLHISNLSWEDS 105
Cdd:cd05775    2 SGEVYGALGGNVTLTISSLQDDIDE-IKWKKTKDKiVEWENNIG-----PTYFGS-FKDRVLLDKESGSLTIKNLTKEDS 74


                 ....
gi 311033512 106 GLYQ 109
Cdd:cd05775   75 GTYE 78
IgV_1_Nectin-3_like cd05887
First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor ...
 30-121 9.38e-03

First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor related protein 3), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 (PVRL3) or cluster of differentiation (CD) 113). Nectin-3 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example, during spermatid development, the nectin-3,-2 trans-interaction is required for the formation of Sertoli cell-spermatid junctions in testis, and during morphogenesis of the ciliary body, the nectin-3,-1 trans-interaction is important for apex-apex adhesion between the pigment and non-pigment layers of the ciliary epithelia. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-3 for example, trans-interacts with Necl-5, regulating cell movement and proliferation. Other proteins with which nectin-3 interacts include the actin filament-binding protein, afadin, integrin alpha-beta3, Par-3, and PDGF receptor; its interaction with PDGF receptor regulates the latter's signaling for anti-apoptosis.


Pssm-ID: 409470  Cd Length: 110  Bit Score: 35.30  E-value: 9.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033512  30 VVAVLQESISLPLEIPPDEEVENIIWSSH--KSLATVVPGkegHPATIMVTNPHYQGQVSFLDPSY---SLHISNLSWED 104
Cdd:cd05887    9 VTAVWGKNVSLKCLIEVNETITQISWEKIhgKSSQTVAVH---HPQYGISIQGEYQGRVSFKNYSLndaTITLHNVGFSD 85

                         90       100
                 ....*....|....*....|
gi 311033512 105 SGLYQAQV---NLRTSQIST 121
Cdd:cd05887   86 SGKYICKAvtfPLGNAQSST 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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