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Conserved domains on  [gi|269849477|sp|Q96DN2|]
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RecName: Full=von Willebrand factor C and EGF domain-containing protein; AltName: Full=HBV X protein up-regulated gene 11 protein; AltName: Full=HBxAg up-regulated gene 11 protein; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 726-944 7.37e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 7.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  726 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 797
Cdd:PHA03247 2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  798 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 867
Cdd:PHA03247 2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 269849477  868 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 944
Cdd:PHA03247 2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 501-559 1.60e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 43.18  E-value: 1.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 269849477  501 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 559
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
572-625 1.26e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 1.26e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 269849477   572 DNGVEFPIGQIWSPgDPCELCICQADGSVSCKRTDC--VDSCPHPIRI--PGQCCPDC 625
Cdd:smart00214   3 HNGRVYNDGETWKP-DPCQICTCLDGTTVLCDPVECppPPDCPNPERVkpPGECCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 386-440 3.62e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 39.33  E-value: 3.62e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 269849477  386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 440
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 629-684 4.52e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member smart00214:

Pssm-ID: 450195  Cd Length: 59  Bit Score: 39.04  E-value: 4.52e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269849477   629 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 684
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 8.96e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 8.96e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 269849477   220 DVNECrrpLERRVCHH--SCHNTVGSFLCTCRPGFRlraDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 1.13e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 269849477   142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 1.22e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*....
gi 269849477  190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 687-742 2.64e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.02  E-value: 2.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 269849477  687 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 742
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 443-488 6.68e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 35.86  E-value: 6.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 269849477  443 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 488
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 726-944 7.37e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 7.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  726 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 797
Cdd:PHA03247 2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  798 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 867
Cdd:PHA03247 2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 269849477  868 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 944
Cdd:PHA03247 2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 501-559 1.60e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.18  E-value: 1.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 269849477  501 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 559
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
572-625 1.26e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 1.26e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 269849477   572 DNGVEFPIGQIWSPgDPCELCICQADGSVSCKRTDC--VDSCPHPIRI--PGQCCPDC 625
Cdd:smart00214   3 HNGRVYNDGETWKP-DPCQICTCLDGTTVLCDPVECppPPDCPNPERVkpPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
501-559 2.71e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.71e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269849477   501 CYFHGRWYADGAVFSGggDECTTCVCQNGE-VECSFMPCPE-LACPREEWRLGPGQCCFTC 559
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 386-440 3.62e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.33  E-value: 3.62e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 269849477  386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 440
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
629-684 4.52e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.04  E-value: 4.52e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269849477   629 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 684
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 8.96e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 8.96e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 269849477   220 DVNECrrpLERRVCHH--SCHNTVGSFLCTCRPGFRlraDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 1.13e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 269849477   142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 1.22e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*....
gi 269849477  190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC smart00214
von Willebrand factor (vWF) type C domain;
386-440 1.28e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.88  E-value: 1.28e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 269849477   386 CWHLGAMHESRSRWTEPGCSQCWCEDGK-VTCEKVRCEAA--CSHPIPSRDGG-CCPSC 440
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpdCPNPERVKPPGeCCPRC 59
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 809-943 1.39e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  809 KTQTLPTSPAGAHGPHSLAlglTATFPGEPGASPRLSPGPstPPGAPTL-PLASPGAPQPP----PVTPERSFSASGAQI 883
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAA---SPPSPPPPGTTQAATAGP--TPSAPSVpPQGSPATSQPPnqtqSTAAPHTLIQQTPTL 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269849477  884 VSRWPPLPGTLLTEASAlsmmDPSPSKTPITLLGPRVL----SPTTSRLSTALAATTHPGPQQP 943
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQ----PPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPPQP 297
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 220-255 1.81e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 1.81e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 269849477 220 DVNECrrpLERRVC--HHSCHNTVGSFLCTCRPGFRLR 255
Cdd:cd00054    1 DIDEC---ASGNPCqnGGTCVNTVGSYRCSCPPGYTGR 35
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 687-742 2.64e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 269849477  687 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 742
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
220-251 3.55e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 3.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 269849477  220 DVNECRRPleRRVCHHS--CHNTVGSFLCTCRPG 251
Cdd:pfam07645   1 DVDECATG--THNCPANtvCVNTIGSFECRCPDG 32
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 629-684 3.55e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.63  E-value: 3.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 269849477  629 CTYTGRIFYNNETFpsVLDPCLSCICLLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 684
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 4.87e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 4.87e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 269849477   181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRTGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 5.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 5.90e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 269849477 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRTGFHLH 212
Cdd:cd00054    1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 443-488 6.68e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.86  E-value: 6.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 269849477  443 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 488
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 726-944 7.37e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 7.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  726 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 797
Cdd:PHA03247 2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  798 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 867
Cdd:PHA03247 2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 269849477  868 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 944
Cdd:PHA03247 2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 501-559 1.60e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.18  E-value: 1.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 269849477  501 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 559
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
572-625 1.26e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 1.26e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 269849477   572 DNGVEFPIGQIWSPgDPCELCICQADGSVSCKRTDC--VDSCPHPIRI--PGQCCPDC 625
Cdd:smart00214   3 HNGRVYNDGETWKP-DPCQICTCLDGTTVLCDPVECppPPDCPNPERVkpPGECCPRC 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 774-944 2.16e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  774 TEAPVNCSSCPGPPTASPSR-PVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATfPGEPGASP----RLSPGP 848
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS-PAGPLPPPtsaqPTAPPP 2841

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  849 STPPGAPTLPLA---SPGAP---QPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLS 922
Cdd:PHA03247 2842 PPGPPPPSLPLGgsvAPGGDvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP 2921

                         170       180
                  ....*....|....*....|..
gi 269849477  923 PTTSRLSTALAATTHPGPQQPP 944
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPL 2943
VWC smart00214
von Willebrand factor (vWF) type C domain;
501-559 2.71e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.71e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269849477   501 CYFHGRWYADGAVFSGggDECTTCVCQNGE-VECSFMPCPE-LACPREEWRLGPGQCCFTC 559
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKPPGECCPRC 59
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
762-944 3.50e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477 762 AFSKAGRSlhGDTeAPVNCSSCP---GPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPG-- 836
Cdd:PRK12323 362 AFRPGQSG--GGA-GPATAAAAPvaqPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAArq 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477 837 ----------EPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLltEASALSMMDP 906
Cdd:PRK12323 439 asargpggapAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEF--ASPAPAQPDA 516

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 269849477 907 SPS---KTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 944
Cdd:PRK12323 517 APAgwvAESIPDPATADPDDAFETLAPAPAAAPAPRAAAAT 557
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 386-440 3.62e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.33  E-value: 3.62e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 269849477  386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 440
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
motB PRK12799
flagellar motor protein MotB; Reviewed
 805-949 4.12e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 43.94  E-value: 4.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477 805 TNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGasprlSPGPSTPPGAPTLPLASPgapqpppvTPERSFSASGAQIV 884
Cdd:PRK12799 288 TGLKQIDTHGTVPVAAVTPSSAVTQSSAITPSSAA-----IPSPAVIPSSVTTQSATT--------TQASAVALSSAGVL 354

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 269849477 885 SRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPR-VLSPTTSRLSTALAATthPGPQQPPVGASR 949
Cdd:PRK12799 355 PSDVTLPGTVALPAAEPVNMQPQPMSTTETQQSSTgNITSTANGPTTSLPAA--PASNIPVSPTSR 418
VWC smart00214
von Willebrand factor (vWF) type C domain;
629-684 4.52e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.04  E-value: 4.52e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269849477   629 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 684
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 784-944 4.54e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 4.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  784 PGPPTASPSRPVLHLLQLLLRTNlmktqtlPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPG 863
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPSE-------PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPP 2629

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  864 APQPPPVT-PERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLsTALAATTHPGPQQ 942
Cdd:PHA03247 2630 SPSPAANEpDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL-TSLADPPPPPPTP 2708


                  ..
gi 269849477  943 PP 944
Cdd:PHA03247 2709 EP 2710
PHA03378 PHA03378
EBNA-3B; Provisional
 804-944 5.08e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477 804 RTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQI 883
Cdd:PHA03378 663 KPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPG 742

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 269849477 884 VSRWPP-LPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 944
Cdd:PHA03378 743 RARPPAaAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGP 804
PHA03378 PHA03378
EBNA-3B; Provisional
 786-949 8.81e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 8.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477 786 PPTASPSRPVLHLLQLLLRTNLMktQTLPTSPAGAHGPH------SLALGLTATFPGEPGASPRlSPGPST------PPG 853
Cdd:PHA03378 616 PETSAPRQWPMPLRPIPMRPLRM--QPITFNVLVFPTPHqppqveITPYKPTWTQIGHIPYQPS-PTGANTmlpiqwAPG 692

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477 854 APTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPiTLLGPRVLSPTTSRLSTAL- 932
Cdd:PHA03378 693 TMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAP-GRARPPAAAPGRARPPAAAp 771

                        170
                 ....*....|....*...
gi 269849477 933 -AATTHPGPQQPPVGASR 949
Cdd:PHA03378 772 gAPTPQPPPQAPPAPQQR 789
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 8.96e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 8.96e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 269849477   220 DVNECrrpLERRVCHH--SCHNTVGSFLCTCRPGFRlraDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 783-955 9.27e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 9.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  783 CPGPPTASPSRPVLHLLQLLLRTnlmktqTLPTSPAGAHGPHSlalGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASP 862
Cdd:PHA03307   72 PPGPGTEAPANESRSTPTWSLST------LAPASPAREGSPTP---PGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  863 G---APQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMmdPSPSKTPITLLGPRVLSPTTSRL-STALAATTHP 938
Cdd:PHA03307  143 SpgpPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAP--SSPPAEPPPSTPPAAASPRPPRRsSPISASASSP 220

                         170
                  ....*....|....*..
gi 269849477  939 GPQQPPVGASRGEESTM 955
Cdd:PHA03307  221 APAPGRSAADDAGASSS 237
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 1.13e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 269849477   142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 1.22e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*....
gi 269849477  190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC smart00214
von Willebrand factor (vWF) type C domain;
386-440 1.28e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.88  E-value: 1.28e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 269849477   386 CWHLGAMHESRSRWTEPGCSQCWCEDGK-VTCEKVRCEAA--CSHPIPSRDGG-CCPSC 440
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpdCPNPERVKPPGeCCPRC 59
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 809-943 1.39e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  809 KTQTLPTSPAGAHGPHSLAlglTATFPGEPGASPRLSPGPstPPGAPTL-PLASPGAPQPP----PVTPERSFSASGAQI 883
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAA---SPPSPPPPGTTQAATAGP--TPSAPSVpPQGSPATSQPPnqtqSTAAPHTLIQQTPTL 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269849477  884 VSRWPPLPGTLLTEASAlsmmDPSPSKTPITLLGPRVL----SPTTSRLSTALAATTHPGPQQP 943
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQ----PPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPPQP 297
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 220-255 1.81e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 1.81e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 269849477 220 DVNECrrpLERRVC--HHSCHNTVGSFLCTCRPGFRLR 255
Cdd:cd00054    1 DIDEC---ASGNPCqnGGTCVNTVGSYRCSCPPGYTGR 35
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
814-954 1.85e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477 814 PTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGT 893
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269849477 894 LLTEASAlsmmdPSPSKTPItllgPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEEST 954
Cdd:PRK12323 445 GGAPAPA-----PAPAAAPA----AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDP 496
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 687-742 2.64e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 269849477  687 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 742
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
220-251 3.55e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 3.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 269849477  220 DVNECRRPleRRVCHHS--CHNTVGSFLCTCRPG 251
Cdd:pfam07645   1 DVDECATG--THNCPANtvCVNTIGSFECRCPDG 32
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 844-944 3.55e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.95  E-value: 3.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477 844 LSPGPSTPPGAPTLPLASPGAPQPPPVTPersFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTpitllgPRVLSP 923
Cdd:PRK14950 360 LVPVPAPQPAKPTAAAPSPVRPTPAPSTR---PKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHT------PESAPK 430

                         90       100
                 ....*....|....*....|.
gi 269849477 924 TTSRLSTALAATTHPGPQQPP 944
Cdd:PRK14950 431 LTRAAIPVDEKPKYTPPAPPK 451
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 629-684 3.55e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.63  E-value: 3.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 269849477  629 CTYTGRIFYNNETFpsVLDPCLSCICLLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 684
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
PHA03379 PHA03379
EBNA-3A; Provisional
 749-945 4.04e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 41.20  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477 749 LEEKQGLSPHGNVAFSKAGRSLHGDteapvncsscPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGP----H 824
Cdd:PHA03379 391 LMRAGKLTERAREALEKASEPTYGT----------PRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPGPlhdqH 460

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477 825 SLALGLTATFPgePGASPRLSPGpSTPPGAPTLPLASPgAPQPPPVTP-ERSFSASGAQIVSRWP------PLPGTLLTE 897
Cdd:PHA03379 461 SMAPCPVAQLP--PGPLQDLEPG-DQLPGVVQDGRPAC-APVPAPAGPiVRPWEASLSQVPGVAFapvmpqPMPVEPVPV 536

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 269849477 898 ASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPV 945
Cdd:PHA03379 537 PTVALERPVCPAPPLIAMQGPGETSGIVRVRERWRPAPWTPNPPRSPS 584
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 4.87e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 4.87e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 269849477   181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRTGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 5.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 5.90e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 269849477 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRTGFHLH 212
Cdd:cd00054    1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 233-261 6.53e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 35.30  E-value: 6.53e-03
                          10        20
                  ....*....|....*....|....*....
gi 269849477  233 CHHSCHNTVGSFLCTCRPGFRLRADRVSC 261
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 443-488 6.68e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.86  E-value: 6.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 269849477  443 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 488
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
PHA03247 PHA03247
large tegument protein UL36; Provisional
 784-945 7.17e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 7.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  784 PGPPTASPSRPVLHLLQLLLRTNLMKTQTL--------PTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAP 855
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPALPAAPappavpagPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  856 TLPLASPGAPQPP-PVTPERSFSASGAQIVSRWPPLPG--TLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTAL 932
Cdd:PHA03247 2790 SLSESRESLPSPWdPADPPAAVLAPAAALPPAASPAGPlpPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869

                         170
                  ....*....|....
gi 269849477  933 AATTHPG-PQQPPV 945
Cdd:PHA03247 2870 SPAAKPAaPARPPV 2883
PHA03247 PHA03247
large tegument protein UL36; Provisional
 784-940 8.71e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  784 PGPPTASPSRPVLHLLQLLLRTNLMK-TQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP-----PGAPTL 857
Cdd:PHA03247 2868 SRSPAAKPAAPARPPVRRLARPAVSRsTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPprpqpPLAPTT 2947

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269849477  858 PLASPGAPQPPPVTPERSFSASGAQIVSRWpplpgtlLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLstALAATTH 937
Cdd:PHA03247 2948 DPAGAGEPSGAVPQPWLGALVPGRVAVPRF-------RVPQPAPSREAPASSTPPLTGHSLSRVSSWASSL--ALHEETD 3018


                  ...
gi 269849477  938 PGP 940
Cdd:PHA03247 3019 PPP 3021
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 202-223 9.61e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 34.31  E-value: 9.61e-03
                          10        20
                  ....*....|....*....|..
gi 269849477  202 KCSCRTGFHLHGNRHSCVDVNE 223
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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