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Conserved domains on  [gi|52782975|sp|Q99LP6|]
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RecName: Full=GrpE protein homolog 1, mitochondrial; AltName: Full=Mt-GrpE#1; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 72-213 1.81e-57

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


:

Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 178.08  E-value: 1.81e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  72 RETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEIsnnnphLKSLYEGLVMTEVQI 151
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE------LKNLLEGVEMTLKQL 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52782975 152 QKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:cd00446  75 LKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 72-213 1.81e-57

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 178.08  E-value: 1.81e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  72 RETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEIsnnnphLKSLYEGLVMTEVQI 151
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE------LKNLLEGVEMTLKQL 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52782975 152 QKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:cd00446  75 LKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
59-215 1.22e-50

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 161.62  E-value: 1.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975    59 TLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEIsnnnphLK 138
Cdd:pfam01025  15 SLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENED------VK 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52782975   139 SLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:pfam01025  89 SLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMVVVSK 165
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 65-215 4.51e-49

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 157.24  E-value: 4.51e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  65 AKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKeeisnnNPHLKSLYEGL 144
Cdd:COG0576   2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEE------DEDVKSLLEGV 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52782975 145 VMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:COG0576  76 EMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 48-215 2.38e-42

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 142.12  E-value: 2.38e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   48 EPKTDPPSADKTLLEEKAKLEEQLREtmeKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPK 127
Cdd:PRK14141  27 KPYEMEDDPEPDPLEALKAENAELKD---RMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALDAIPA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  128 EEISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLR 207
Cdd:PRK14141 104 EARAAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTVVQVVQAGYTIGERVLR 183


                 ....*...
gi 52782975  208 PALVGVVK 215
Cdd:PRK14141 184 PAMVGVAK 191
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 72-213 1.81e-57

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 178.08  E-value: 1.81e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  72 RETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEIsnnnphLKSLYEGLVMTEVQI 151
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE------LKNLLEGVEMTLKQL 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52782975 152 QKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:cd00446  75 LKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
59-215 1.22e-50

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 161.62  E-value: 1.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975    59 TLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEIsnnnphLK 138
Cdd:pfam01025  15 SLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENED------VK 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52782975   139 SLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:pfam01025  89 SLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMVVVSK 165
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 65-215 4.51e-49

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 157.24  E-value: 4.51e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  65 AKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKeeisnnNPHLKSLYEGL 144
Cdd:COG0576   2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEE------DEDVKSLLEGV 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52782975 145 VMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:COG0576  76 EMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 48-215 2.38e-42

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 142.12  E-value: 2.38e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   48 EPKTDPPSADKTLLEEKAKLEEQLREtmeKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPK 127
Cdd:PRK14141  27 KPYEMEDDPEPDPLEALKAENAELKD---RMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALDAIPA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  128 EEISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLR 207
Cdd:PRK14141 104 EARAAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTVVQVVQAGYTIGERVLR 183


                 ....*...
gi 52782975  208 PALVGVVK 215
Cdd:PRK14141 184 PAMVGVAK 191
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 49-213 7.11e-34

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 120.46  E-value: 7.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   49 PKTDPPSADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKE 128
Cdd:PRK14155   7 PAEDGPFEADDAAQEIEALKAEVAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRATAASPKD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  129 eisNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDP-IGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLR 207
Cdd:PRK14155  87 ---SADPAVKNFIIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYELMGRLVR 163


                 ....*.
gi 52782975  208 PALVGV 213
Cdd:PRK14155 164 PAMVAV 169
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 33-215 2.72e-32

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 115.46  E-value: 2.72e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   33 QKNNGQNLDEDLGHCEPKTDPPSADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLL 112
Cdd:PRK14139  10 EQEAEEAGAAAQAAAAAAAAAEDAAPALEAELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAESLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  113 EVADILEKAtqsvpkeeISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGkEPGTVA 192
Cdd:PRK14139  90 PVKDSLEAA--------LADESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPAEQ-EPNTVV 160

                        170       180
                 ....*....|....*....|...
gi 52782975  193 LVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14139 161 AVLQKGYTIADRVLRPALVTVAA 183
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 38-215 1.02e-30

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 111.74  E-value: 1.02e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   38 QNLDEDLGHCEPKTDPPSAdkTLLEEKAKL-EEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVAD 116
Cdd:PRK14144  29 EETDEESQHQEPALGHPSY--TALEEQLTLaEQKAHENWEKSVRALAELENVRRRMEREVANAHKYGVEKLISALLPVVD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  117 ILEKATQSVPKeeisNNNPhlkSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSK 196
Cdd:PRK14144 107 SLEQALQLADK----NSDP---SMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPPNSVITVFQ 179

                        170
                 ....*....|....*....
gi 52782975  197 VGYKLHGRTLRPALVGVVK 215
Cdd:PRK14144 180 KGYKLSDRVIRPARVIVST 198
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 48-213 3.96e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 110.09  E-value: 3.96e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   48 EPKTDPPSADKTLLEEKAK---LEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQs 124
Cdd:PRK14140  27 EETVEEESEAELLDEEQAKiaeLEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQ- 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  125 vpkeeISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGR 204
Cdd:PRK14140 106 -----IEADDEQTKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDR 180


                 ....*....
gi 52782975  205 TLRPALVGV 213
Cdd:PRK14140 181 VIRPSMVKV 189
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 42-215 5.55e-30

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 109.10  E-value: 5.55e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   42 EDLGHCEPKTDPPSADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKA 121
Cdd:PRK14151   7 LDLQAPEAAQAEAAAGDDLTARVQELEEQLAAAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  122 TqsvpkEEISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKL 201
Cdd:PRK14151  87 L-----ELSSADDEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQKGYLL 161

                        170
                 ....*....|....
gi 52782975  202 HGRTLRPALVGVVK 215
Cdd:PRK14151 162 NGRLLRPAMVVVSK 175
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 32-215 4.77e-27

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 101.92  E-value: 4.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   32 KQKNNGQNLDEDLGHCEPKTDPPSADKTL--LEEK----AKLEEQLRETMEKYK----RALADTENLRQRSQKLVEEAKL 101
Cdd:PRK14150   5 EQKTPQEQVSEEIEAEVEQQEEADEAELEdeLDEAdariAELEAQLAEAQAEERdsvlRARAEVENIRRRAEQDVEKAHK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  102 YGIQGFCKDLLEVADILEKATQSVPKEeisnnNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHT 181
Cdd:PRK14150  85 FALEKFANELLPVIDNLERALQAADKE-----NEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQ 159

                        170       180       190
                 ....*....|....*....|....*....|....
gi 52782975  182 PVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14150 160 ESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMVSK 193
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 42-216 4.09e-26

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 99.25  E-value: 4.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   42 EDLGHCEPKTDPPSADKtlleekakleEQLRETMEKYK----RALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADI 117
Cdd:PRK14147  11 EDLAQNPPETDPLKAEV----------ESLRSEIALVKadalRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  118 LEKATQSvpkeeiSNNNPHlkSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKV 197
Cdd:PRK14147  81 LDAGLTA------AGTEPS--PLRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQK 152

                        170
                 ....*....|....*....
gi 52782975  198 GYKLHGRTLRPALVGVVKD 216
Cdd:PRK14147 153 GYLLNERLLRPALVVVAKQ 171
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 42-216 8.71e-25

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 96.09  E-value: 8.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   42 EDLGHCEPKTDPPSADKTLLE--EKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILE 119
Cdd:PRK14149  21 EKACACKEQQGEEKQEASEKEgeIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  120 KATQSvpkeeiSNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGaKFDPYEHEALFHTPVEGKEPGTVALVSKVGY 199
Cdd:PRK14149 101 GALKS------AAEVDKESALTKGLELTMEKLHEVLARHGIEGIECLE-EFDPNFHNAIMQVKSEEKENGKIVQVLQQGY 173

                        170
                 ....*....|....*..
gi 52782975  200 KLHGRTLRPALVGVVKD 216
Cdd:PRK14149 174 KYKGRVLRPAMVSIAKN 190
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 55-216 1.37e-24

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 95.68  E-value: 1.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   55 SADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEISNnn 134
Cdd:PRK14153  33 PEDSTADSETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLDLLEVTDNFERALESARTAEDMN-- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  135 phlkSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVV 214
Cdd:PRK14153 111 ----SIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVPDNTIVDVCKPGYALNSKVIRPAMVSVA 186


                 ..
gi 52782975  215 KD 216
Cdd:PRK14153 187 RN 188
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 62-215 2.28e-24

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 94.66  E-value: 2.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   62 EEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPkeeiSNNNPHLKSLY 141
Cdd:PRK14161  26 PEITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKP----ANSDVEVTNII 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52782975  142 EGLVMTEVQIQKVFTKHGLLRLDP-IGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14161 102 AGVQMTKDELDKVFHKHHIEEIKPeIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKIRDRLLRPATVQVVK 176
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 63-215 4.18e-23

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 91.29  E-value: 4.18e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   63 EKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEISnnnphLKsLYE 142
Cdd:PRK14159  31 EQNKLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVNVECHDEIS-----LK-IKE 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52782975  143 GLVMTEVQIQKVFTKHGLLRLDPIGaKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14159 105 GVQNTLDLFLKKLEKHGVALIKEEK-EFDPNLHEAMFHVDSENHQSGEVVQVLQKGYKIADRVIRPTKVSVAK 176
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 32-216 8.84e-22

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 88.66  E-value: 8.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   32 KQKNNGQNLDEDL-GHCEPKTDPPSADKTLleEKAKLEEQLR----------ETMEKYK----RALADTENLRQRSQKLV 96
Cdd:PRK14148   4 QEKSNVEDKSLDIeTAAQVETAQESASGAL--EELSVEEQLErakdtikeleDSCDQFKdealRAKAEMENIRKRAERDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   97 EEAKLYGIQGFCKDLLEVADILEKATQSVPKEEisnnnpHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHE 176
Cdd:PRK14148  82 SNARKFGIEKFAKELLPVIDSIEQALKHEVKLE------EAIAMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 52782975  177 ALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKD 216
Cdd:PRK14148 156 AMAMIPNPEFEDNTIFDVFQKGYMLNGRIVRAAKVVIVKN 195
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 62-215 1.02e-20

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 85.88  E-value: 1.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   62 EEKAKLEEQLRETMEKYK----RALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEeisnnNPHL 137
Cdd:PRK10325  42 EKIANLEAQLAEAQTRERdgilRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKA-----NPDM 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52782975  138 KSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK10325 117 SAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 48-213 1.91e-19

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 82.19  E-value: 1.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   48 EPKTDPPSADKTLLE---EKAKLEEQLRETMEKYKRALADTENLRQRSQKlvEEAKL--YGIQGFCKDLLEVADILEKAT 122
Cdd:PRK14162  29 APKEEDQEKQNPVEDlekEIADLKAKNKDLEDKYLRSQAEIQNMQNRYAK--ERAQLikYESQSLAKDVLPAMDNLERAL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  123 QSVPKEEISnnnphlKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEP-GTVALVSKVGYKL 201
Cdd:PRK14162 107 AVKADDEAA------KQLKKGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQTVAAENDDQkDHVVQVLQKGYQY 180

                        170
                 ....*....|..
gi 52782975  202 HGRTLRPALVGV 213
Cdd:PRK14162 181 KDRTLRPAMVVV 192
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 35-215 1.39e-18

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 79.96  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   35 NNGQNLDEDLGHCEPKTDPPSADKtLLEEKAKL---EEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDL 111
Cdd:PRK14145  23 EQMEGPPEDEQAQQNQPQQQTVDE-IEELKQKLqqkEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILEL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  112 LEVADILEKATQsvpkeeisnNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTV 191
Cdd:PRK14145 102 LPVMDNFERALA---------SSGDYNSLKEGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVEGKQPNEI 172

                        170       180
                 ....*....|....*....|....
gi 52782975  192 ALVSKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14145 173 IEVFQKGYYLKDKVIRPSLVKVAK 196
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 48-215 5.69e-18

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 78.43  E-value: 5.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   48 EPKTDPPSAD--KTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSV 125
Cdd:PRK14158  31 EAAQPVAAADriKELEEALAAKEAEAAANWDKYLRERADLENYRKRVQKEKEELLKYGNESLILEILPAVDNMERALDHA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  126 PKEEISnnnphlkSLYEGLVMTEVQIQKVFTKHGLLRLD-PIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGR 204
Cdd:PRK14158 111 DEESMS-------AIIEGIRMTLSMLLSTLKKFGVTPVEaEKGTPFDPAYHQAMCQVESAEQEPNTVVAVFQKGYLLNER 183

                        170
                 ....*....|.
gi 52782975  205 TLRPALVGVVK 215
Cdd:PRK14158 184 LLRPAMVSVAT 194
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 48-213 6.83e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 78.31  E-value: 6.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   48 EPKTDP---PSADKtLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQS 124
Cdd:PRK14154  43 EPHREGlefPSREK-LEGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDLLPVADSLIHGLES 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  125 VPKEEisnnnPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDP-IGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHG 203
Cdd:PRK14154 122 PASED-----PQVKSMRDGMSLTLDLLHNTLAKHGVQVINPnPGDPFDPALHEAMSVQAVPDAKPDTIIQVLQKGYQLNG 196

                        170
                 ....*....|
gi 52782975  204 RTLRPALVGV 213
Cdd:PRK14154 197 RVLRAARVIV 206
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 48-213 1.28e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 75.53  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   48 EPKTDPPSADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPK 127
Cdd:PRK14143  60 ETAADNAARLAQLEQELESLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQQLKP 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  128 EEISNNNPHlKSlYEGLVMtevQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLR 207
Cdd:PRK14143 140 EGEEAQALH-RS-YQGLYK---QLVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLR 214


                 ....*.
gi 52782975  208 PALVGV 213
Cdd:PRK14143 215 HAMVKV 220
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 52-215 5.93e-12

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 62.44  E-value: 5.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   52 DPPSADKTLLEEKAKLEEQLRETmekYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEK--ATQsvpkee 129
Cdd:PRK14146  54 ETETSLQKELDNAKKEIESLKDS---WARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERvgATQ------ 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  130 isNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALfhTPVEGKE--PGTVALVSKVGYKLH----G 203
Cdd:PRK14146 125 --NQSEELKPFVEGVKMILKEFYSVLEKSNVIRFDPKGEPFDPMSMEAL--SSEEGDQysEETVIDVYQAGYYYKenedK 200

                        170
                 ....*....|..
gi 52782975  204 RTLRPALVGVVK 215
Cdd:PRK14146 201 FTLRPARVRIGK 212
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 55-213 1.92e-10

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 58.43  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   55 SADKTLLE-EKAKLEEQlrETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKAtqsvpkEEISNN 133
Cdd:PRK14157  78 DSDDTLTPlGQAKKEAA--EYLEALQRERAEFINYRNRTQKEQDRFRQHGIIDVLTALLPALDDIDRI------REHSEM 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  134 NPHLKSLyeglvmtEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:PRK14157 150 DDSFKAV-------AAKIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKPDPDAEKETVDTVVEAGYRIGDRVIRAARVVV 222
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 58-213 2.02e-08

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 52.45  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   58 KTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATqsvpkeeisNNNPHL 137
Cdd:PRK14160  64 NKLKEENKKLENELEALKDRLLRTVAEYDNYRKRTAKEKEGIYSDACEDVLKELLPVLDNLERAA---------AVEGSV 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52782975  138 KSLYEGLVMTEVQIQKVFTKHGLLRLDPIGaKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGV 213
Cdd:PRK14160 135 EDLKKGIEMTVKQFKTSLEKLGVEEISTEG-EFDPNLHNAVMHVEDENYGENEIVEVFQKGYKRGDKVIRYSMVKV 209
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 48-215 2.97e-08

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 52.05  E-value: 2.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   48 EPKTDP-----PSADKT----LLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADIL 118
Cdd:PRK14163  24 EPKAASeegaaPAGDAAatagLTAQLDQVRTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVLDDV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  119 EKATQSvpKEEISNnnphLKSLYEGLvmtevqiQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVG 198
Cdd:PRK14163 104 GRAREH--GELVGG----FKSVAESL-------ETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQPG 170

                        170
                 ....*....|....*..
gi 52782975  199 YKLHGRTLRPALVGVVK 215
Cdd:PRK14163 171 YRIGERTIRPARVAVAE 187
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 38-214 6.17e-08

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 51.15  E-value: 6.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   38 QNLDEDLGHCE--PKTDPPSAdkTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVA 115
Cdd:PRK14142  16 RRIDPETGEVRhvPPGDMPGG--TAAADAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  116 DILEKATQSVPKEeisnNNPhLKSLYEGLvmtevqiQKVFTKHGLLRLDPIGAKFDPYEHEALFHT--PVEGKEPgTVAL 193
Cdd:PRK14142  94 DDLERARKHGDLE----SGP-LKSVADKL-------DSALTGLGLVAFGAEGEDFDPVLHEAVQHEgdGGQGSKP-VIGT 160

                        170       180
                 ....*....|....*....|.
gi 52782975  194 VSKVGYKLHGRTLRPALVGVV 214
Cdd:PRK14142 161 VMRQGYQLGEQVLRHALVGVV 181
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 62-213 3.81e-06

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 45.59  E-value: 3.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975   62 EEKAKLEEQLRETME---KYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKA------TQSVPKeeisn 132
Cdd:PRK14156  31 PEKSELELANERADEfenKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNLERAlaveglTDDVKK----- 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52782975  133 nnphlkslyeGLVMTEVQIQKVFTKHGLLRLDpiGAKFDPYEHEALFHTPVEGKEPG-TVALVSKVGYKLHGRTLRPALV 211
Cdd:PRK14156 106 ----------GLEMVQESLIQALKEEGVEEVA--VDSFDHNLHMAVQTLPADDEHPAdSIAQVFQKGYKLHERLLRPAMV 173


                 ..
gi 52782975  212 GV 213
Cdd:PRK14156 174 VV 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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