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Conserved domains on  [gi|81905590|sp|Q9D7S0|]
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RecName: Full=Ly6/PLAUR domain-containing protein 8; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_LYPD8_rpt1 cd23568
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and ...
 17-108 5.26e-34

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and similar proteins; LYPD8 is a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein selectively expressed on colonic enterocytes. It mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of interleukin 6 (IL 6) and tumor necrosis factor alpha (TNF alpha). LYPD8 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467098  Cd Length: 95  Bit Score: 118.32  E-value: 5.26e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905590  17 VVDSLNCTQCYTYNSTCDGQ-ATECNE-QSFSCVESSINSTLGGFLHVYQNKFCSASNCTENST-EVAFTVHLFDDQRYH 93
Cdd:cd23568   1 AVESLNCVQCNSLTNSCVNVsATECPLnASTSCVSSSVNSTLGGTLMLYQNKSCSASNCSGNSDvLVAFTVHVSDNERFH 80

                        90
                ....*....|....*
gi 81905590  94 FASQCCQGESCNATH 108
Cdd:cd23568  81 FASQCCQGKSCNNTS 95
TFP_LU_ECD_LYPD8_rpt2 cd23569
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and ...
 117-194 1.70e-33

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and similar proteins; LYPD8 is a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein selectively expressed on colonic enterocytes. It mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of interleukin 6 (IL 6) and tumor necrosis factor alpha (TNF alpha). LYPD8 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467099  Cd Length: 78  Bit Score: 116.38  E-value: 1.70e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81905590 117 TDMQCMSCYGHNKTLCEEKPQKCYEGEQCVFIIAEMVNGSGRVELKGCSDISNSTCQFLSPGNTTVGEFVFKSVECTQ 194
Cdd:cd23569   1 QNMECPACYGYNTTSCVEKPSKCCQGERCVNLVAELENGSSRLVLKGCSNISNSTCQFLSTGNQTVGGVIFRKFECAD 78
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD8_rpt1 cd23568
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and ...
 17-108 5.26e-34

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and similar proteins; LYPD8 is a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein selectively expressed on colonic enterocytes. It mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of interleukin 6 (IL 6) and tumor necrosis factor alpha (TNF alpha). LYPD8 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467098  Cd Length: 95  Bit Score: 118.32  E-value: 5.26e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905590  17 VVDSLNCTQCYTYNSTCDGQ-ATECNE-QSFSCVESSINSTLGGFLHVYQNKFCSASNCTENST-EVAFTVHLFDDQRYH 93
Cdd:cd23568   1 AVESLNCVQCNSLTNSCVNVsATECPLnASTSCVSSSVNSTLGGTLMLYQNKSCSASNCSGNSDvLVAFTVHVSDNERFH 80

                        90
                ....*....|....*
gi 81905590  94 FASQCCQGESCNATH 108
Cdd:cd23568  81 FASQCCQGKSCNNTS 95
TFP_LU_ECD_LYPD8_rpt2 cd23569
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and ...
 117-194 1.70e-33

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and similar proteins; LYPD8 is a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein selectively expressed on colonic enterocytes. It mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of interleukin 6 (IL 6) and tumor necrosis factor alpha (TNF alpha). LYPD8 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467099  Cd Length: 78  Bit Score: 116.38  E-value: 1.70e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81905590 117 TDMQCMSCYGHNKTLCEEKPQKCYEGEQCVFIIAEMVNGSGRVELKGCSDISNSTCQFLSPGNTTVGEFVFKSVECTQ 194
Cdd:cd23569   1 QNMECPACYGYNTTSCVEKPSKCCQGERCVNLVAELENGSSRLVLKGCSNISNSTCQFLSTGNQTVGGVIFRKFECAD 78
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD8_rpt1 cd23568
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and ...
 17-108 5.26e-34

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and similar proteins; LYPD8 is a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein selectively expressed on colonic enterocytes. It mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of interleukin 6 (IL 6) and tumor necrosis factor alpha (TNF alpha). LYPD8 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467098  Cd Length: 95  Bit Score: 118.32  E-value: 5.26e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905590  17 VVDSLNCTQCYTYNSTCDGQ-ATECNE-QSFSCVESSINSTLGGFLHVYQNKFCSASNCTENST-EVAFTVHLFDDQRYH 93
Cdd:cd23568   1 AVESLNCVQCNSLTNSCVNVsATECPLnASTSCVSSSVNSTLGGTLMLYQNKSCSASNCSGNSDvLVAFTVHVSDNERFH 80

                        90
                ....*....|....*
gi 81905590  94 FASQCCQGESCNATH 108
Cdd:cd23568  81 FASQCCQGKSCNNTS 95
TFP_LU_ECD_LYPD8_rpt2 cd23569
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and ...
 117-194 1.70e-33

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 8 (LYPD8) and similar proteins; LYPD8 is a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein selectively expressed on colonic enterocytes. It mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of interleukin 6 (IL 6) and tumor necrosis factor alpha (TNF alpha). LYPD8 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467099  Cd Length: 78  Bit Score: 116.38  E-value: 1.70e-33
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81905590 117 TDMQCMSCYGHNKTLCEEKPQKCYEGEQCVFIIAEMVNGSGRVELKGCSDISNSTCQFLSPGNTTVGEFVFKSVECTQ 194
Cdd:cd23569   1 QNMECPACYGYNTTSCVEKPSKCCQGERCVNLVAELENGSSRLVLKGCSNISNSTCQFLSTGNQTVGGVIFRKFECAD 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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