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Conserved domains on  [gi|20455420|sp|Q9KL20|]
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RecName: Full=23S rRNA (uracil(747)-C(5))-methyltransferase RlmC; AltName: Full=23S rRNA(m5U747)-methyltransferase

Protein Classification

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC( domain architecture ID 11493609)

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
meth_trns_rumB TIGR02085
23S rRNA (uracil-5-)-methyltransferase RumB; This family consists of RNA methyltransferases ...
 2-374 0e+00

23S rRNA (uracil-5-)-methyltransferase RumB; This family consists of RNA methyltransferases designated RumB, formerly YbjF. Members act on 23S rRNA U747 and the equivalent position in other proteobacterial species. This family is homologous to the other 23S rRNA methyltransferase RumA and to the tRNA methyltransferase TrmA. [Protein synthesis, tRNA and rRNA base modification]


:

Pssm-ID: 131140  Cd Length: 374  Bit Score: 693.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420     2 QCEFFIQKRCTSCHLCAQPYSEQVTNKDQQLRELIAP-ATDVQWLPPVTSADTAFRNKAKMVVLGAAHAPILGIEDAQGQ 80
Cdd:TIGR02085   1 QCAFYIQGRCRSCQWLAQPYSEQLTNKQQHLKELLAPnATVVQWLAPVTSAEQAFRNKAKMVVSGSVERPILGILHRDGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420    81 PLSLVTCPLYPQPMQELLAYLENWIRIAGIPPYNKLKKKGELKFILLTRSENSGQFMLRFVARSHAVLERIERNLPTLIA 160
Cdd:TIGR02085  81 PLDLCDCPLYPQSFQPVFAYLKNFIARAGLTPYNVAKKKGELKFILLTESENSGQLMLRFVLRSETKLAQIRRALPWLIE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   161 AFPMIEVISVNIQPVHMARLEGEEEIFLTETQSLLEHFNDVPMVIRPKSFFQTNPKVAEQLYATARTWVREIAPTQMWDL 240
Cdd:TIGR02085 161 QLPQLEVISVNIQPVHMAILEGEEEIFLTEQQALPERFNDVPLVIRPQSFFQTNPKVAAQLYATARQWVREIPVTQMWDL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   241 FCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQSQMSAPELVLVNPPRRGLGSELTAQ 320
Cdd:TIGR02085 241 FCGVGGFGLHCAGPDTQLTGIEIESEAIACAQQSAQMLGLDNLSFAALDSAKFATAQMSAPELVLVNPPRRGIGKELCDY 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 20455420   321 LEALAPKYILYSSCNPQTMVKDIAELSSYQMIRVQWFDMFPHTDHAEVLTLLVR 374
Cdd:TIGR02085 321 LSQMAPKFILYSSCNAQTMAKDIAELSGYQIERVQLFDMFPHTSHYEVLTLLVR 374
 
Name Accession Description Interval E-value
meth_trns_rumB TIGR02085
23S rRNA (uracil-5-)-methyltransferase RumB; This family consists of RNA methyltransferases ...
 2-374 0e+00

23S rRNA (uracil-5-)-methyltransferase RumB; This family consists of RNA methyltransferases designated RumB, formerly YbjF. Members act on 23S rRNA U747 and the equivalent position in other proteobacterial species. This family is homologous to the other 23S rRNA methyltransferase RumA and to the tRNA methyltransferase TrmA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 131140  Cd Length: 374  Bit Score: 693.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420     2 QCEFFIQKRCTSCHLCAQPYSEQVTNKDQQLRELIAP-ATDVQWLPPVTSADTAFRNKAKMVVLGAAHAPILGIEDAQGQ 80
Cdd:TIGR02085   1 QCAFYIQGRCRSCQWLAQPYSEQLTNKQQHLKELLAPnATVVQWLAPVTSAEQAFRNKAKMVVSGSVERPILGILHRDGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420    81 PLSLVTCPLYPQPMQELLAYLENWIRIAGIPPYNKLKKKGELKFILLTRSENSGQFMLRFVARSHAVLERIERNLPTLIA 160
Cdd:TIGR02085  81 PLDLCDCPLYPQSFQPVFAYLKNFIARAGLTPYNVAKKKGELKFILLTESENSGQLMLRFVLRSETKLAQIRRALPWLIE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   161 AFPMIEVISVNIQPVHMARLEGEEEIFLTETQSLLEHFNDVPMVIRPKSFFQTNPKVAEQLYATARTWVREIAPTQMWDL 240
Cdd:TIGR02085 161 QLPQLEVISVNIQPVHMAILEGEEEIFLTEQQALPERFNDVPLVIRPQSFFQTNPKVAAQLYATARQWVREIPVTQMWDL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   241 FCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQSQMSAPELVLVNPPRRGLGSELTAQ 320
Cdd:TIGR02085 241 FCGVGGFGLHCAGPDTQLTGIEIESEAIACAQQSAQMLGLDNLSFAALDSAKFATAQMSAPELVLVNPPRRGIGKELCDY 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 20455420   321 LEALAPKYILYSSCNPQTMVKDIAELSSYQMIRVQWFDMFPHTDHAEVLTLLVR 374
Cdd:TIGR02085 321 LSQMAPKFILYSSCNAQTMAKDIAELSGYQIERVQLFDMFPHTSHYEVLTLLVR 374
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
61-375 0e+00

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 584.52  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   61 MVVLGAAHAPILGIEDAQGQPLSLVTCPLYPQPMQELLAYLENWIRIAGIPPYNKLKKKGELKFILLTRSENSGQFMLRF 140
Cdd:PRK03522   1 MVVSGSVERPLLGILHRDGTPVDLCDCPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGELMLRF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  141 VARSHAVLERIERNLPTLIAAFPMIEVISVNIQPVHMARLEGEEEIFLTETQSLLEHFNDVPMVIRPKSFFQTNPKVAEQ 220
Cdd:PRK03522  81 VLRSETKLARLRRALPWLQAQLPQLKVISVNIQPVHMAILEGEEEIFLTEQQALPERFNGVPLFIRPQSFFQTNPAVAAQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  221 LYATARTWVREIAPTQMWDLFCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQSQMSA 300
Cdd:PRK03522 161 LYATARDWVRELPPRSMWDLFCGVGGFGLHCATPGMQLTGIEISAEAIACAKQSAAELGLTNVQFQALDSTQFATAQGEV 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455420  301 PELVLVNPPRRGLGSELTAQLEALAPKYILYSSCNPQTMVKDIAELSSYQMIRVQWFDMFPHTDHAEVLTLLVRK 375
Cdd:PRK03522 241 PDLVLVNPPRRGIGKELCDYLSQMAPRFILYSSCNAQTMAKDLAHLPGYRIERVQLFDMFPHTAHYEVLTLLVRQ 315
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 3-373 1.34e-90

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 277.06  E-value: 1.34e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   3 CEFFiqKRCTSCHLCAQPYSEQVTNKDQQLREL---IAPATDVQWLPPVTSADT-AFRNKAKMVVLGAAHAPILGIEDAQ 78
Cdd:COG2265  67 CPHF--GRCGGCQLQHLSYEAQLELKQRVVREAlerIGGLPEVEVEPIIGSPEPwGYRNRARLSVRRTDGRLRLGFYARG 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  79 G-QPLSLVTCPLYPQPMQELLAYLENWIRIAGippynklKKKGELKFILLTrsensgqfmlrfvarshavleriernlpt 157
Cdd:COG2265 145 ShELVDIDECPLLDPALNALLPALRELLAELG-------ARRGELRHLVVR----------------------------- 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420 158 liaafpmievisvniqpvhmarlEGEEEIFltetqsllEHFNDVPMVIRPKSFFQTNPKVAEQLYATARTWVREIAPTQM 237
Cdd:COG2265 189 -----------------------AGRDYLT--------ERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERV 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420 238 WDLFCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKF--SQSQMSAPELVLVNPPRRGLGS 315
Cdd:COG2265 238 LDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVlpELLWGGRPDVVVLDPPRAGAGP 317

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420 316 ELTAQLEALAPKYILYSSCNPQTMVKDIAELSS--YQMIRVQWFDMFPHTDHAEVLTLLV 373
Cdd:COG2265 318 EVLEALAALGPRRIVYVSCNPATLARDLALLVEggYRLEKVQPVDMFPHTHHVESVALLE 377
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 209-375 4.30e-22

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 95.97  E-value: 4.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   209 SFFQTNPKVAEQLYatarTWVREIAPTQMWDL---FCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSF 285
Cdd:pfam05958 178 SFTQPNAAVNIKML----EWACDVTQGSKGDLlelYCGNGNFSLALARNFRKVLATEIAKPSVAAAQYNIAANNIDNVQI 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   286 AALDSAKFSQSQMSAPEL---------------VLVNPPRRGLGSEltaqLEALAPKY--ILYSSCNPQTMVKDIAELS- 347
Cdd:pfam05958 254 IRMSAEEFTQAMNGVREFnrlkgidlksyncstIFVDPPRAGLDPE----TLKLVQAYprILYISCNPETLCANLEQLSk 329

                         170       180
                  ....*....|....*....|....*...
gi 20455420   348 SYQMIRVQWFDMFPHTDHAEVLTLLVRK 375
Cdd:pfam05958 330 THRVERFALFDQFPYTHHMECGVLLEKK 357
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 238-309 3.72e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.11  E-value: 3.72e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20455420 238 WDLFCGVGGFALHCA-APDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQSQMSAPELVLVNPP 309
Cdd:cd02440   3 LDLGCGTGALALALAsGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPP 75
 
Name Accession Description Interval E-value
meth_trns_rumB TIGR02085
23S rRNA (uracil-5-)-methyltransferase RumB; This family consists of RNA methyltransferases ...
 2-374 0e+00

23S rRNA (uracil-5-)-methyltransferase RumB; This family consists of RNA methyltransferases designated RumB, formerly YbjF. Members act on 23S rRNA U747 and the equivalent position in other proteobacterial species. This family is homologous to the other 23S rRNA methyltransferase RumA and to the tRNA methyltransferase TrmA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 131140  Cd Length: 374  Bit Score: 693.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420     2 QCEFFIQKRCTSCHLCAQPYSEQVTNKDQQLRELIAP-ATDVQWLPPVTSADTAFRNKAKMVVLGAAHAPILGIEDAQGQ 80
Cdd:TIGR02085   1 QCAFYIQGRCRSCQWLAQPYSEQLTNKQQHLKELLAPnATVVQWLAPVTSAEQAFRNKAKMVVSGSVERPILGILHRDGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420    81 PLSLVTCPLYPQPMQELLAYLENWIRIAGIPPYNKLKKKGELKFILLTRSENSGQFMLRFVARSHAVLERIERNLPTLIA 160
Cdd:TIGR02085  81 PLDLCDCPLYPQSFQPVFAYLKNFIARAGLTPYNVAKKKGELKFILLTESENSGQLMLRFVLRSETKLAQIRRALPWLIE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   161 AFPMIEVISVNIQPVHMARLEGEEEIFLTETQSLLEHFNDVPMVIRPKSFFQTNPKVAEQLYATARTWVREIAPTQMWDL 240
Cdd:TIGR02085 161 QLPQLEVISVNIQPVHMAILEGEEEIFLTEQQALPERFNDVPLVIRPQSFFQTNPKVAAQLYATARQWVREIPVTQMWDL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   241 FCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQSQMSAPELVLVNPPRRGLGSELTAQ 320
Cdd:TIGR02085 241 FCGVGGFGLHCAGPDTQLTGIEIESEAIACAQQSAQMLGLDNLSFAALDSAKFATAQMSAPELVLVNPPRRGIGKELCDY 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 20455420   321 LEALAPKYILYSSCNPQTMVKDIAELSSYQMIRVQWFDMFPHTDHAEVLTLLVR 374
Cdd:TIGR02085 321 LSQMAPKFILYSSCNAQTMAKDIAELSGYQIERVQLFDMFPHTSHYEVLTLLVR 374
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
61-375 0e+00

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 584.52  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   61 MVVLGAAHAPILGIEDAQGQPLSLVTCPLYPQPMQELLAYLENWIRIAGIPPYNKLKKKGELKFILLTRSENSGQFMLRF 140
Cdd:PRK03522   1 MVVSGSVERPLLGILHRDGTPVDLCDCPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGELMLRF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  141 VARSHAVLERIERNLPTLIAAFPMIEVISVNIQPVHMARLEGEEEIFLTETQSLLEHFNDVPMVIRPKSFFQTNPKVAEQ 220
Cdd:PRK03522  81 VLRSETKLARLRRALPWLQAQLPQLKVISVNIQPVHMAILEGEEEIFLTEQQALPERFNGVPLFIRPQSFFQTNPAVAAQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  221 LYATARTWVREIAPTQMWDLFCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQSQMSA 300
Cdd:PRK03522 161 LYATARDWVRELPPRSMWDLFCGVGGFGLHCATPGMQLTGIEISAEAIACAKQSAAELGLTNVQFQALDSTQFATAQGEV 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455420  301 PELVLVNPPRRGLGSELTAQLEALAPKYILYSSCNPQTMVKDIAELSSYQMIRVQWFDMFPHTDHAEVLTLLVRK 375
Cdd:PRK03522 241 PDLVLVNPPRRGIGKELCDYLSQMAPRFILYSSCNAQTMAKDLAHLPGYRIERVQLFDMFPHTAHYEVLTLLVRQ 315
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 3-373 1.34e-90

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 277.06  E-value: 1.34e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   3 CEFFiqKRCTSCHLCAQPYSEQVTNKDQQLREL---IAPATDVQWLPPVTSADT-AFRNKAKMVVLGAAHAPILGIEDAQ 78
Cdd:COG2265  67 CPHF--GRCGGCQLQHLSYEAQLELKQRVVREAlerIGGLPEVEVEPIIGSPEPwGYRNRARLSVRRTDGRLRLGFYARG 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  79 G-QPLSLVTCPLYPQPMQELLAYLENWIRIAGippynklKKKGELKFILLTrsensgqfmlrfvarshavleriernlpt 157
Cdd:COG2265 145 ShELVDIDECPLLDPALNALLPALRELLAELG-------ARRGELRHLVVR----------------------------- 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420 158 liaafpmievisvniqpvhmarlEGEEEIFltetqsllEHFNDVPMVIRPKSFFQTNPKVAEQLYATARTWVREIAPTQM 237
Cdd:COG2265 189 -----------------------AGRDYLT--------ERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERV 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420 238 WDLFCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKF--SQSQMSAPELVLVNPPRRGLGS 315
Cdd:COG2265 238 LDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVlpELLWGGRPDVVVLDPPRAGAGP 317

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420 316 ELTAQLEALAPKYILYSSCNPQTMVKDIAELSS--YQMIRVQWFDMFPHTDHAEVLTLLV 373
Cdd:COG2265 318 EVLEALAALGPRRIVYVSCNPATLARDLALLVEggYRLEKVQPVDMFPHTHHVESVALLE 377
rumA TIGR00479
23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA ...
 9-367 4.52e-45

23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129571 [Multi-domain]  Cd Length: 431  Bit Score: 160.37  E-value: 4.52e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420     9 KRCTSCHLCAQPYSEQVTNKDQQLRELIAPAT-----DVQWLPPVTSADTAFRNKAKM---------VVLGAAHAPILGI 74
Cdd:TIGR00479  62 GQCGGCQLQHLSYELQLRSKQQQVIALLERIGkfvsePIEDVPTIGDDPWGYRNKARLslgrspsgqLQAGFYQKGSHDI 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420    75 EDAQgqplslvTCPLYPQPMQELLAYLENWIRIAGIPPYNKLKKKGELKFILLTRSENSGQFMLRFVARsHAVLERIERN 154
Cdd:TIGR00479 142 VDVK-------QCPVQAPALNALLPKVRAILENFGASRYLEHKELGQARHGVLRIGRHTGELSSVDRTA-LERFPHKEEL 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   155 LPTLIAAFPMIEVISVNIQPVHMARLEGEEEIFLTETQSLLEHFNDVPMVIRPKSFFQTNPKVAEQLYATARTWVREIAP 234
Cdd:TIGR00479 214 DLYLQPDSPDVKSICQNINPEKTNVIFGEETEVIAGEMPIYDKSGDLSFTFSARDFIQVNSGQNEKLVDRALEWLELQGE 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   235 TQMWDLFCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQSQMSA---PELVLVNPPRR 311
Cdd:TIGR00479 294 ERVLDAYCGMGTFTLPLAKQAKSVVGVEGVPESVEKAQQNAELNGIANVTFYHGTLETVLPKQPWAgngFDKVLLDPPRK 373

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 20455420   312 GLGSELTAQLEALAPKYILYSSCNPQTMVKDIAELSS--YQMIRVQWFDMFPHTDHAE 367
Cdd:TIGR00479 374 GCAAGVLRTIIKLKPERIVYVSCNPATLARDLEALCKagYTIARVQPVDMFPHTGHVE 431
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
3-375 6.76e-33

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 127.58  E-value: 6.76e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420    3 CEFFiqKRCTSC---HLcaqPYSEQVTNKDQQLREL---IAPATDVQWLPPVTSADTAFRNKAKmvvLGAAHAP-----I 71
Cdd:PRK13168  80 CPHF--GVCGGCqlqHL---SIDAQIASKQRALEDLlkhLAGVEPEEVLPPIAGPPWGYRRRAR---LSVRYVPkkgqlL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   72 LGIEDAQGQPL-SLVTCPLYPQPMQELLAYLENWIriagippyNKLKKKGELKFILLTRSENSgqfmlrfvarsHAVLER 150
Cdd:PRK13168 152 VGFREKNSSDIvDIDQCPVLVPPLSALLPPLRALL--------SSLSAKRRLGHVELAQGDNG-----------TALVLR 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  151 IERNLP----TLIAAFPMIEVISVNIQPvhmarlEGEEEIFLTETQSLLEHF----NDVPMVIRPKSFFQTNPKVAEQLY 222
Cdd:PRK13168 213 HLEPLSeadrAKLRAFAEQHGLQLYLQP------KGPDLVHLLGPADAQLSYylpeFGLRLAFSPRDFIQVNAQVNQKMV 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  223 ATARTWVrEIAPTQ-MWDLFCGVGGFAL---HCAApdtAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALD-SAKFS-QS 296
Cdd:PRK13168 287 ARALEWL-DPQPGDrVLDLFCGLGNFTLplaRQAA---EVVGVEGVEAMVERARENARRNGLDNVTFYHANlEEDFTdQP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  297 QMSAP-ELVLVNPPRRGlGSELTAQLEALAPKYILYSSCNPQTMVKDIAEL--SSYQMIRVQWFDMFPHTDHAEVLTLLV 373
Cdd:PRK13168 363 WALGGfDKVLLDPPRAG-AAEVMQALAKLGPKRIVYVSCNPATLARDAGVLveAGYRLKRAGMLDMFPHTGHVESMALFE 441


                 ..
gi 20455420  374 RK 375
Cdd:PRK13168 442 RG 443
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 209-375 4.30e-22

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 95.97  E-value: 4.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   209 SFFQTNPKVAEQLYatarTWVREIAPTQMWDL---FCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSF 285
Cdd:pfam05958 178 SFTQPNAAVNIKML----EWACDVTQGSKGDLlelYCGNGNFSLALARNFRKVLATEIAKPSVAAAQYNIAANNIDNVQI 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   286 AALDSAKFSQSQMSAPEL---------------VLVNPPRRGLGSEltaqLEALAPKY--ILYSSCNPQTMVKDIAELS- 347
Cdd:pfam05958 254 IRMSAEEFTQAMNGVREFnrlkgidlksyncstIFVDPPRAGLDPE----TLKLVQAYprILYISCNPETLCANLEQLSk 329

                         170       180
                  ....*....|....*....|....*...
gi 20455420   348 SYQMIRVQWFDMFPHTDHAEVLTLLVRK 375
Cdd:pfam05958 330 THRVERFALFDQFPYTHHMECGVLLEKK 357
PRK05031 PRK05031
tRNA (uracil-5-)-methyltransferase; Validated
 209-375 5.79e-22

tRNA (uracil-5-)-methyltransferase; Validated


Pssm-ID: 235332  Cd Length: 362  Bit Score: 95.67  E-value: 5.79e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  209 SFFQTNPKVAEQLYatarTWVREIAPTQMWDL---FCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSF 285
Cdd:PRK05031 183 SFTQPNAAVNEKML----EWALDATKGSKGDLlelYCGNGNFTLALARNFRRVLATEISKPSVAAAQYNIAANGIDNVQI 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420  286 AALDSAKFSQSqMS----------------APELVLVNPPRRGLGSElTAQLeALAPKYILYSSCNPQTMVKDIAELS-S 348
Cdd:PRK05031 259 IRMSAEEFTQA-MNgvrefnrlkgidlksyNFSTIFVDPPRAGLDDE-TLKL-VQAYERILYISCNPETLCENLETLSqT 335

                        170       180
                 ....*....|....*....|....*..
gi 20455420  349 YQMIRVQWFDMFPHTDHAEVLTLLVRK 375
Cdd:PRK05031 336 HKVERFALFDQFPYTHHMECGVLLEKK 362
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 239-365 8.56e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.14  E-value: 8.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420 239 DLFCGVGGFALHCAAPDTA-VTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQSQMSAPELVL-------VNPPR 310
Cdd:COG0500  32 DLGCGTGRNLLALAARFGGrVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDPLPAESFDLVVafgvlhhLPPEE 111

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20455420 311 RglgSELTAQL-EALAPKYILYSSCnpqtmVKDIAELSSYQMIRVQWFDMFPHTDH 365
Cdd:COG0500 112 R---EALLRELaRALKPGGVLLLSA-----SDAAAALSLARLLLLATASLLELLLL 159
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 238-309 3.72e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.11  E-value: 3.72e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20455420 238 WDLFCGVGGFALHCA-APDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQSQMSAPELVLVNPP 309
Cdd:cd02440   3 LDLGCGTGALALALAsGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPP 75
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 239-309 3.59e-05

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 44.03  E-value: 3.59e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455420 239 DLFCGVG--GFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSF------AALDSAKFSqsqmsapeLVLVNPP 309
Cdd:COG2813  55 DLGCGYGviGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVlwsdglSGVPDGSFD--------LILSNPP 125
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 239-296 5.42e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.79  E-value: 5.42e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20455420   239 DLFCGVGGFALHCA---APDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAALDSAKFSQS 296
Cdd:pfam13847   9 DLGCGTGHLSFELAeelGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPEL 69
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 228-309 1.80e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 42.44  E-value: 1.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420 228 WVREIAPTQMWDLFCGVGGFALHCAA--PDTAVTGIEIEPEAIASAQRSAQMMGIDN-LSFAALDSAKFSQSQMSAP-EL 303
Cdd:COG4123  32 FAPVKKGGRVLDLGTGTGVIALMLAQrsPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAELPPGSfDL 111


                ....*.
gi 20455420 304 VLVNPP 309
Cdd:COG4123 112 VVSNPP 117
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 239-309 2.68e-04

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 41.17  E-value: 2.68e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455420   239 DLFCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLSFAA----LDSAKFSQSQMSAPELVLVNPP 309
Cdd:pfam09445   6 DVFCGGGGNTIQFANVFDSVISIDINLEHLACAQHNAEVYGVSDRIWLIhgdwFELLAKLKFEKIKYDCVFASPP 80
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 239-319 3.33e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 41.04  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455420   239 DLFCGVGGFALHCAA--PDTAVTGIEIEPEAIASAQRSAQMMGIDNLSF------AALDSAKFsqsqmsapELVLVNPP- 309
Cdd:pfam05175  37 DLGCGAGVLGAALAKesPDAELTMVDINARALESARENLAANGLENGEVvasdvySGVEDGKF--------DLIISNPPf 108

                          90
                  ....*....|
gi 20455420   310 RRGLGSELTA 319
Cdd:pfam05175 109 HAGLATTYNV 118
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 239-277 7.90e-04

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 41.00  E-value: 7.90e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20455420 239 DLFCGVGGFALHCAAPDTA-VTGIEIEPEAIASAQRSAQM 277
Cdd:COG2520 186 DMFAGVGPFSIPIAKRSGAkVVAIDINPDAVEYLKENIRL 225
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 222-289 1.25e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 38.82  E-value: 1.25e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20455420 222 YATARTWVREIAPT---QMWDLFCGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIdNLSFAALD 289
Cdd:COG2226   8 YDGREALLAALGLRpgaRVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGD 77
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 239-283 3.05e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 37.99  E-value: 3.05e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 20455420 239 DLFCGVGGFALHCAA-PDTAVTGIEIEPEAIASAQRSAQMMGIDNL 283
Cdd:COG2230  57 DIGCGWGGLALYLARrYGVRVTGVTLSPEQLEYARERAAEAGLADR 102
PRK14968 PRK14968
putative methyltransferase; Provisional
 242-309 4.85e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 37.57  E-value: 4.85e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20455420  242 CGVGGFALHCAAPDTAVTGIEIEPEAIASAQRSAQMMGIDNLS--------FAALDSAKFsqsqmsapELVLVNPP 309
Cdd:PRK14968  32 TGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNGvevirsdlFEPFRGDKF--------DVILFNPP 99
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 239-289 5.52e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 36.00  E-value: 5.52e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 20455420   239 DLFCGVGGFALHCA-APDTAVTGIEIEPEAIASAQRSAQMMGIdNLSFAALD 289
Cdd:pfam13649   3 DLGCGTGRLTLALArRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGD 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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