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Conserved domains on  [gi|20455271|sp|Q9NSD7|]
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RecName: Full=Relaxin-3 receptor 1; Short=RLN3 receptor 1; AltName: Full=G protein-coupled receptor SALPR; AltName: Full=G-protein coupled receptor GPCR135; AltName: Full=Relaxin family peptide receptor 3; AltName: Full=Somatostatin- and angiotensin-like peptide receptor

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11610399)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
82-400 0e+00

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


:

Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 511.75  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15926   1 IIISIVYSVVCALGLVGNLLVLYLMKSKQGWKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15926  81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRG---------------CCSAKWLCVLIWVLAILASLPNAIFSTTATV 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLlgRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRraagtkggaavaggRPTGASARRL 321
Cdd:cd15926 146 SNEELCLVKFPDNR--GNAQFWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFITDK--------------NITGSSTKRR 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15926 210 SKVTKSVTIVVLSFFLCWLPNQALTTWGILIKLNVVHFSYEYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
 
Name Accession Description Interval E-value
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
82-400 0e+00

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 511.75  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15926   1 IIISIVYSVVCALGLVGNLLVLYLMKSKQGWKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15926  81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRG---------------CCSAKWLCVLIWVLAILASLPNAIFSTTATV 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLlgRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRraagtkggaavaggRPTGASARRL 321
Cdd:cd15926 146 SNEELCLVKFPDNR--GNAQFWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFITDK--------------NITGSSTKRR 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15926 210 SKVTKSVTIVVLSFFLCWLPNQALTTWGILIKLNVVHFSYEYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
98-389 1.21e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 175.18  E-value: 1.21e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271    98 GNLLVLYLM---KSMQgwrkSSINLFVTNLALTDFQF-VLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFL 173
Cdd:pfam00001   1 GNLLVILVIlrnKKLR----TPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271   174 TAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTT--VKVMGEELCLVRF 251
Cdd:pfam00001  77 TAISIDRYLAIVHPLRYKRRRTPRR---------------AKVLILVIWVLALLLSLPPLLFGWTltVPEGNVTVCFIDF 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271   252 PDKLlgrDRQFWLGLYHSqkvLLGFVLPLGIIILCYLLLVRFIADRRAAGtkggaavaggrPTGASARRLSKVTKSVTIV 331
Cdd:pfam00001 142 PEDL---SKPVSYTLLIS---VLGFLLPLLVILVCYTLIIRTLRKSASKQ-----------KSSERTQRRRKALKTLAVV 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271   332 VLSFFLCWLPNQALTTWSILIKFNAVPfsqeyfLCQVYAFPVSVCLAHSNSCLNPVLY 389
Cdd:pfam00001 205 VVVFILCWLPYHIVNLLDSLALDCELS------RLLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
80-404 9.94e-33

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 126.82  E-value: 9.94e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271   80 VRILISVVYWVVCALGLAGNLLVLYLMKSMQGwrKSSINLFVTNLALTDFQFVLTLPFWaVENALDFKWPFGKAMCKIVS 159
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIYVLTKTKI--KTPMDIYLLNLAVSDLLFVMTLPFQ-IYYYILFQWSFGEFACKIVS 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  160 MVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGdccgrslgdsccfsaKALCVWIWALAALASLPSAIFSTTV 239
Cdd:PHA03087 116 GLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYG---------------YIVSLVIWIISIIETTPILFVYTTK 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  240 KVMGEELCLVRFPDKllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggrpTGASAR 319
Cdd:PHA03087 181 KDHETLICCMFYNNK-----TMNWKLFINFEINIIGMLIPLTILLYCYSKILITLK------------------GINKSK 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  320 RLSKVTKSVTIVVLSFFLCWLPnqalttwsilikFNAVPFSQEYFLCQV-----------YAFPVSVCLAHSNSCLNPVL 388
Cdd:PHA03087 238 KNKKAIKLVLIIVILFVIFWLP------------FNVSVFVYSLHILHFksgckavkyiqYALHVTEIISLSHCCINPLI 305
                        330
                 ....*....|....*.
gi 20455271  389 YCLVRREFRKALKSLL 404
Cdd:PHA03087 306 YAFVSEFFNKHKKKSL 321
 
Name Accession Description Interval E-value
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
82-400 0e+00

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 511.75  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15926   1 IIISIVYSVVCALGLVGNLLVLYLMKSKQGWKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15926  81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRG---------------CCSAKWLCVLIWVLAILASLPNAIFSTTATV 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLlgRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRraagtkggaavaggRPTGASARRL 321
Cdd:cd15926 146 SNEELCLVKFPDNR--GNAQFWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFITDK--------------NITGSSTKRR 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15926 210 SKVTKSVTIVVLSFFLCWLPNQALTTWGILIKLNVVHFSYEYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
82-400 8.58e-154

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 438.47  E-value: 8.58e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRK-SSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd14976   1 NLVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQqSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdsCCFSAKALCVWIWALAALASLPSAIFST-TV 239
Cdd:cd14976  81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIR---------------KAFGAFATTIAIWAAAALAAIPEAIFSTdTW 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptGASAR 319
Cdd:cd14976 146 SSVNHTLCLLRFPKNSSVTRWYNWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKR----------------GGSKR 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd14976 210 RKSRVTKSVFIVVLSFFICWLPNQALSLWSALIKFDDVPFSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDA 289

                .
gi 20455271 400 L 400
Cdd:cd14976 290 L 290
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
82-400 3.29e-103

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 309.50  E-value: 3.29e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15925   1 ILVALAYGLVCAIGLLGNLAVMYLLRNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgrslgdSCCFSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15925  81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTH---------------LSTFWAKIITLALWAAALLATVPTAIFATEGEV 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKllgrdrqFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaaVAGGRPtgasaRRL 321
Cdd:cd15925 146 CGVELCLLKFPSN-------YWLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHK---------VNQNNR-----QRQ 204
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15925 205 SVIARSVRLVVASFFLCWFPNHVVTFWGVLVKFRAVPWNSTFYFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
82-398 8.89e-63

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 205.22  E-value: 8.89e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFkWPFGKAMCKIVSMV 161
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSK-MKTVTNIYILNLAVADELFLLGLPFLATSYLLGY-WPFGEVMCKIVLSV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd14970  79 DAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRK---------------AKLVSLCVWALSLVLGLPVIIFARTLQE 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEEL-CLVRFPDkllgrDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTkggaavaggRPTGASARR 320
Cdd:cd14970 144 EGGTIsCNLQWPD-----PPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLST---------SGAREKRRA 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFsqeyflcQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd14970 210 RRKVTRLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETLT-------VVGVFLFCIALSYANSCLNPILYAFLDENFRK 280
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
83-400 5.47e-57

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 190.28  E-value: 5.47e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSsINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd14985   2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRV-ADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgRGDCcgrslgdsccfsAKALCVWIWALAALASLPSAIFSTT--VK 240
Cdd:cd14985  81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLR---RRRQ------------ARVTCALIWVVACLLSLPTFLLRSLqaIE 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKLLgrdrQFWLGLyhsQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGaavaggrptgasaRR 320
Cdd:cd14985 146 NLNKTACIMLYPHEAW----HFGLSL---ELNILGFVLPLLIILTCYFHIARSLRKRYERTGKNG-------------RK 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAV-PFSQEYFLcqVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd14985 206 RRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLGAIrPCFWELFL--DLGLPIATCLAFTNSCLNPFIYVFVDRRFRQK 283

                .
gi 20455271 400 L 400
Cdd:cd14985 284 V 284
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
83-399 4.53e-53

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 180.73  E-value: 4.53e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15190  12 LIPVIYMLVFVLGLSGNGLVLWTVFRSKRKRRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLV 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGdccgrslgdsccfsAKALCVwIWALAALASLPSAIFSTTVKVM 242
Cdd:cd15190  92 FVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSG--------------IVALGV-IWLLAALLALPALILRTTSDLE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 GEE--LCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTkggaavaggRPTGASARR 320
Cdd:cd15190 157 GTNkvICDMDYSGVVSNESEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLR---------RKEDKKKRR 227
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 321 LSKVtksVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15190 228 LLKI---IITLVVTFALCWLPFHLVKTLYALMYLGILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
83-400 4.04e-52

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 177.63  E-value: 4.04e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMkSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15191   2 AIPVLYSIIFILGFLGNSLVVCVF-CHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTT--VK 240
Cdd:cd15191  81 TLNLFASIFFITCMSVDRYLAVVYPLRSQRRRSW----------------QARLVCLLVWVLACLSSLPTFYFRDTyyIE 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKllgRDRQFWLGLYhSQKVLLGFVLPLGIIILCYLLLVRFIadrraAGTKGgaavaggrpTGASARR 320
Cdd:cd15191 145 ELGVNACIMAFPNE---KYAQWSAGLA-LMKNTLGFLIPLIVIATCYFGIGRHL-----LKTKG---------FGKNKQR 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFsqeyflCQVYAF-----PVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15191 207 RDKVLKMVAAVVLAFLICWFPFHVLTFLDALARMGVINN------CWVITVidkalPFAICLGFSNSCINPFLYCFVGNH 280

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd15191 281 FREKL 285
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
82-400 1.07e-51

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 175.95  E-value: 1.07e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSmqGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd14974   1 IVSLVLYALIFLLGLPGNGLVIWVAGF--KMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd14974  79 ISLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRL---------------ASVVCVGIWILALVLSVPYFVFRDTVTH 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKL-LGRDRQFWLGLYhsqKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTkggaavaggrptgasarr 320
Cdd:cd14974 144 HNGRSCNLTCVEDYdLRRSRHKALTVI---RFLCGFLLPLLIIAICYSVIAVKLRRKRLAKS------------------ 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 lSKVTKSVTIVVLSFFLCWLPNQALttwsILIKFNAVPFSQEYFLCqvyAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd14974 203 -SKPLRVLLAVVVAFFLCWLPYHVF----ALLELVAAAGLPEVVLL---GLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
98-389 1.21e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 175.18  E-value: 1.21e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271    98 GNLLVLYLM---KSMQgwrkSSINLFVTNLALTDFQF-VLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFL 173
Cdd:pfam00001   1 GNLLVILVIlrnKKLR----TPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271   174 TAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTT--VKVMGEELCLVRF 251
Cdd:pfam00001  77 TAISIDRYLAIVHPLRYKRRRTPRR---------------AKVLILVIWVLALLLSLPPLLFGWTltVPEGNVTVCFIDF 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271   252 PDKLlgrDRQFWLGLYHSqkvLLGFVLPLGIIILCYLLLVRFIADRRAAGtkggaavaggrPTGASARRLSKVTKSVTIV 331
Cdd:pfam00001 142 PEDL---SKPVSYTLLIS---VLGFLLPLLVILVCYTLIIRTLRKSASKQ-----------KSSERTQRRRKALKTLAVV 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271   332 VLSFFLCWLPNQALTTWSILIKFNAVPfsqeyfLCQVYAFPVSVCLAHSNSCLNPVLY 389
Cdd:pfam00001 205 VVVFILCWLPYHIVNLLDSLALDCELS------RLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
82-400 2.71e-51

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 175.31  E-value: 2.71e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVL----YLMKsmqgwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKI 157
Cdd:cd15192   1 IMIPTVYSIIFVVGIFGNSLVViviyCYMK-----LKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdsCCFSAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15192  76 ASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRR---------------TLVVARVTCIVIWLLAGVASLPAIIHRD 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TV--KVMGEELCLVRFPDkllgRDRQFWLGLYHSqKVLLGFVLPLGIIILCYLLLvrfiadrraagtkgGAAVAGGRPTG 315
Cdd:cd15192 141 VFfiENTNITVCAFHYPS----QNSTLLVGLGLM-KNLLGFLIPFLIILTCYTLI--------------GKALKKAYEIQ 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 ASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFsqeyflCQVY-----AFPVSVCLAHSNSCLNPVLYC 390
Cdd:cd15192 202 RNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQLKVIQD------CHIAdivdtAMPFTICIAYFNSCLNPILYG 275
                       330
                ....*....|
gi 20455271 391 LVRREFRKAL 400
Cdd:cd15192 276 FVGKNFRKKF 285
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
84-391 2.35e-50

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 172.47  E-value: 2.35e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQF-VLTLPFWAVENALDFkWPFGKAMCKIVSMVT 162
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLR-TVTNYFILNLAVADLLVgLLVIPFSLVSLLLGR-WWFGDALCKLLGFLQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVM 242
Cdd:cd00637  79 SVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRR---------------AKLLIALIWLLSLLLALPPLLGWGVYDYG 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 GEELCLVRFPDkllgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtKGGAAVAGGRPTGASARRLS 322
Cdd:cd00637 144 GYCCCCLCWPD-------LTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHR----RRIRSSSSNSSRRRRRRRER 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 323 KVTKSVTIVVLSFFLCWLPNQALTTWSIlikfnavpFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCL 391
Cdd:cd00637 213 KVTKTLLIVVVVFLLCWLPYFILLLLDV--------FGPDPSPLPRILYFLALLLAYLNSAINPIIYAF 273
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
82-400 8.62e-50

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 171.29  E-value: 8.62e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYL----MKSmqgwrKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKI 157
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVflrkMKK-----RSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIF-S 236
Cdd:cd14982  76 TGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRY---------------AVGVCAGVWILVLVASVPLLLLrS 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 237 TTVKVMGEELCLVRFPDKLLgrdrqfWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGgaavaggrptga 316
Cdd:cd14982 141 TIAKENNSTTCFEFLSEWLA------SAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKS------------ 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 saRRLSKVTKSVTIVVLSFFLCWLP---NQALTTWSILIKFNAVPFSQEYFlcqvYAFPVSVCLAHSNSCLNPVLYCLVR 393
Cdd:cd14982 203 --VRKRKALRMILIVLAVFLVCFLPyhvTRILYLLVRLSFIADCSARNSLY----KAYRITLCLASLNSCLDPLIYYFLS 276

                ....*..
gi 20455271 394 REFRKAL 400
Cdd:cd14982 277 KTFRKRL 283
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
82-400 1.29e-49

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 170.71  E-value: 1.29e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15088   1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLR-TAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKS--HRTRghgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTTV 239
Cdd:cd15088  80 DANNQFTSTYILTAMSVDRYLAVVHPIRStkYRTR-----------------FVAKLVNVGLWAASFLSILPVWVYSSLI 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVM-GEELCLVRFPDKllgrDRQFWLGLYHsqkVLLGFVLPLGIIILCYLLLVRFIADrraagtkggaAVAGGRPTGASa 318
Cdd:cd15088 143 YFPdGTTFCYVSLPSP----DDLYWFTIYH---FILGFAVPLVVITVCYILILHRLAR----------GVAPGNQSHGS- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLcqvyafpvSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15088 205 SRTKRVTKMVILIVVVFIVCWLPFHVVQLVNLAMNRPTLAFEVAYFL--------SICLGYANSCLNPFVYILVSENFRK 276

                ..
gi 20455271 399 AL 400
Cdd:cd15088 277 RL 278
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
82-400 1.37e-49

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 170.47  E-value: 1.37e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLY-LMKSMQGWRKSSINLFvtNLALTDFQFVLTLPFWAVENALDfkWPFGKAMCKIVSM 160
Cdd:cd14984   1 VFLPVLYSLVFLLGLVGNSLVLLvLLYYRKLRSMTDVYLL--NLALADLLFVLTLPFWAVYAADG--WVFGSFLCKLVSA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGdccgrslgdsccfsaKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd14984  77 LYTINFYSGILFLACISIDRYLAIVHAVSALRARTLLHG---------------KLTCLGVWALALLLSLPEFIFSQVSE 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKLLgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadRRAAGTKGGAAVaggrptgasarr 320
Cdd:cd14984 142 ENGSSICSYDYPEDTA----TTWKTLLRLLQNILGFLLPLLVMLFCYSRIIRTL--LRARNHKKHRAL------------ 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 lskvtKSVTIVVLSFFLCWLPnqalttwsilikFNAVPFSQEYFLCQV------------YAFPVSVCLAHSNSCLNPVL 388
Cdd:cd14984 204 -----RVIFAVVVVFFLCWLP------------YNIVLLLDTLQLLGIisrscelsksldYALQVTESLAFSHCCLNPVL 266
                       330
                ....*....|..
gi 20455271 389 YCLVRREFRKAL 400
Cdd:cd14984 267 YAFVGVKFRKYL 278
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-398 3.75e-47

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 164.17  E-value: 3.75e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFkWPFGKAMCKIVSMV 161
Cdd:cd15093   1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAK-MKTVTNIYILNLAIADELFMLGLPFLAASNALRH-WPFGSVLCRLVLSV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFS-TTVK 240
Cdd:cd15093  79 DGINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPR---------------VAKVVNLAVWVASLLVILPVVVFAgTREN 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadrRAAGTKGgaavaggrptGASARR 320
Cdd:cd15093 144 QDGSSACNMQWPEP-----AAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKV---KSAGLRA----------GWQQRK 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LS--KVTKSVTIVVLSFFLCWLPNQALTTWSILikfnaVPFSQEYFLCQVYAFpvSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15093 206 RSerKVTRMVVMVVVVFVICWLPFYVLQLVNVF-----VQLPETPALVGVYHF--VVILSYANSCANPILYGFLSDNFKK 278
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
82-398 1.24e-45

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 160.30  E-value: 1.24e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSsINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15193   1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRL-VDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSH--RTRGHGRGDCCGrslgdsccfsakalcvwIWALAALASLPSAIFSttv 239
Cdd:cd15193  80 IAVNRCSSILFLTGMSVDRYLAVVKLLDSRplRTRRCALITCCI-----------------IWAVSLVLGIPSLVYR--- 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELClVRFPDKLLGRDrqFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGaavaggrptgasaR 319
Cdd:cd15193 140 NLINESVC-VEDSSSRFFQG--ISLAT-----LFLTFVLPLIVILFCYCSILVRLRRHFHGAKRTG-------------R 198
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15193 199 RRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLELGGGVLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
82-400 4.29e-45

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 158.81  E-value: 4.29e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMksmqgWRKSSI----NLFVTNLALTDFQFVLTLPFWAVENALDFkWPFGKAMCKI 157
Cdd:cd15972   1 VLIPLVYLVVCVVGLGGNTLVIYVV-----LRYSASesvtNIYILNLALADELFMLGLPFLAAQNALSY-WPFGSFMCRL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRgHGRgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15972  75 VMTVDAINQFTSIFCLTVMSVDRYLAVVHPIRSSKWR-KPP--------------VAKTVNATVWALSFLVVLPVVIFSG 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEelCLVRFPDKllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVrfiADRRAAGTKGGAAvaggrptgAS 317
Cdd:cd15972 140 VPGGMGT--CHIAWPEP-----AQVWRAGFIIYTATLGFFCPLLVICLCYLLIV---VKVRSSGRRVRAT--------ST 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLS--KVTKSVTIVVLSFFLCWLPNQALTTWSILikfnaVPFSQEYFLCQVYAFpvSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15972 202 KRRGSerKVTRMVVIVVAAFVLCWLPFYALNIVNLV-----CPLPEEPSLFGLYFF--VVVLSYANSCANPIIYGFLSDN 274

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd15972 275 FKQGF 279
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
82-400 4.35e-43

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 153.36  E-value: 4.35e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSmqGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15119   1 IVSIVIYIVAFVLGVPGNAIVIWVTGF--KWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15119  79 AVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLK---------------SALILCGIVWLSAAAISGPALYFRDTMEL 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 -MGEELCLVRFPDkllgRDRQFWLGLYHSQKVL---LGFVLPLGIIILCYLLLVRFIADRRAAgtkggaavaggrptgas 317
Cdd:cd15119 144 sINVTICFNNFHK----HDGDLIVMRHTILVWVrffFGFLFPLLTMVVCYSLLAIKVKRRTLL----------------- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 arRLSKVTKSVTIVVLSFFLCWLPNQALTTWSIlikfnAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15119 203 --ISSKFFWTISAVIVAFFVCWTPYHIFSILEL-----SIHHSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFK 275

                ...
gi 20455271 398 KAL 400
Cdd:cd15119 276 AHL 278
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
82-400 1.08e-42

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 152.23  E-value: 1.08e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMkSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfkWPFGKAMCKIVSMV 161
Cdd:cd15179   1 IFLPTVYSIIFLLGIVGNGLVILVM-GYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAAN--WYFGNFLCKAVHVI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15179  78 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRK---------------LLAEKVVYVGVWLPALLLTVPDLVFAKVSEL 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKllgrDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggRPTGASARrl 321
Cdd:cd15179 143 DDRYICDRIYPED----TFELWVVAFRFQHILVGLVLPGLVILTCYCIIISKLS----------------HSKGHQKR-- 200
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 322 sKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15179 201 -KALKTTVILILAFFACWLPYYIGISIDTFMLLEIIKQSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 278
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
82-400 2.62e-41

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 148.84  E-value: 2.62e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALdFKWPFGKAMCKIVSMV 161
Cdd:cd15971   1 AFLTFIYFVVCIIGLCGNTLVIYVILRYAK-MKTVTNIYILNLAIADELFMLGLPFLAIQVAL-VHWPFGKAICRVVMTV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15971  79 DGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRT---------------AKMINMAVWGVSLLVILPIMIYAGVQTK 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDkllgrDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLvrfIADRRAAGTKggaavaggrpTGASARRL 321
Cdd:cd15971 144 HGRSSCTIIWPG-----ESSAWYTGFIIYTFILGFFVPLTIICLCYLFI---IIKVKSSGIR----------VGSSKRKK 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 S--KVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEyflcqvyAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15971 206 SekKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISPTPGLKG-------MFDFVVVLSYANSCANPILYAFLSDNFKKS 278

                .
gi 20455271 400 L 400
Cdd:cd15971 279 F 279
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
82-399 3.44e-41

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 148.34  E-value: 3.44e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVL-YLMKSMQGWRKSSINLFVTNLALTDFQFVL-TLPFWAVENALDfKWPFGKAMCKIVS 159
Cdd:cd15098   1 VIVPVVFGLIFCLGVLGNSLVItVLARVKPGKRRSTTNVFILNLSIADLFFLLfCVPFQATIYSLP-EWVFGAFMCKFVH 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdSCCFSAKALCVwIWALAALASLPSAIFSTTV 239
Cdd:cd15098  80 YFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLR--------------TRRNALLGVLV-IWVLSLAMASPVAVHQDLV 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVM---GEELCLVRFPDKLlgrdrqfWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavaggrptgA 316
Cdd:cd15098 145 HHWtasNQTFCWENWPEKQ-------QKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKLKNMSK------------K 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 SARRLSKVTKSVTIVVLSFFLCWLPNQALTTWsilIKFNAVPFSQEYFLCQVyafpVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15098 206 SERSKKKTAQTVLVVVVVFGISWLPHHIIHLW---VEFGDFPLTQASFVLRI----TAHCLAYANSCVNPIIYAFLSENF 278

                ...
gi 20455271 397 RKA 399
Cdd:cd15098 279 RKA 281
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
82-399 9.65e-41

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 147.26  E-value: 9.65e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFkWPFGKAMCKIVSMV 161
Cdd:cd15974   1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAK-MKTVTNIYILNLAVADELFMLGLPFLATQNAISY-WPFGSFLCRLVMTV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15974  79 DGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPR---------------VAKLINATVWTLSFLVVLPVIIFSDVQPD 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEelCLVRFPDKllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadrRAAGTKggaavaggrpTGASARRL 321
Cdd:cd15974 144 LNT--CNISWPEP-----VSVWSTAFIIYTAVLGFFGPLLVICLCYLLIVIKV---KSSGLR----------VGSTKRRK 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 S--KVTKSVTIVVLSFFLCWLPNQALTTWSIlikfnAVPFSQEYFLCQVYAFpvSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15974 204 SerKVTRMVVIIVVVFVFCWLPFYMLNIVNL-----IVILPEEPAFVGVYFF--VVVLSYANSCANPILYGFLSDNFKQS 276
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
82-400 1.93e-40

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 146.31  E-value: 1.93e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYL-MKSMQGWRKSSINLFvtNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15168   1 IFLPIVYGVVFLVGLLLNSVVLYRfIFHLKPWNSSAIYMF--NLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRtrgHGRGDCcgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15168  79 LFYFNLYGSILFLTCISVHRYLGICHPLRSLG---KLKKRH------------AVAISVAVWILVLLQLLPILFFATTGR 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKLLGRDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRFIAdRRAagtkggaavaggrPTGASARR 320
Cdd:cd15168 144 KNNRTTCYDTTSPEELNDYVIYSMVL-----TGLGFLLPLLIILACYGLIVRALI-RKL-------------GEGVTSAL 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15168 205 RRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLLSGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
89-398 4.75e-40

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 145.30  E-value: 4.75e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  89 WVVCALGLAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYA 168
Cdd:cd15189   8 FSLCLFGLLGNLFVL-LVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 169 SVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTTVKVMGEEL-- 246
Cdd:cd15189  87 SIYLLVMISQDRYLALVKTMAARRLRRR---------------RYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNIta 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 CLVRFPDKLlgrdrqfWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGaavaggrptgasaRRLSKVTK 326
Cdd:cd15189 152 CVLLYPHEA-------WHFAHIVLLNIVGFLLPLLVITFCNYNILQALRTREESTRCED-------------RNDSKATA 211
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20455271 327 SVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVyAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15189 212 LVLAVTLLFLVCWGPYHFFTFLDFLFDVGVLDECFWEHFIDI-GLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
82-400 7.58e-40

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 145.05  E-value: 7.58e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM---KSMQgwrkSSINLFVTNLALTD-FQFVLTLPFWAVEnALDFKWPFGKAMCKI 157
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVlrnKSMQ----TVTNIFILNLAVSDlLLCLVSLPFTLIY-TLTKNWPFGSILCKL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15203  76 VPSLQGVSIFVSTLTLTAIAIDRYQLIVYPTRPRMS-----------------KRHALLIIALIWILSLLLSLPLAIFQE 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEEL------CLVRFPDKllgRDRQfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGG 311
Cdd:cd15203 139 LSDVPIEILpycgyfCTESWPSS---SSRL----IYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRR 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 RptGASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVP-FSQEYFLcqvYAFPVSVCLAHSNSCLNPVLYC 390
Cdd:cd15203 212 R--RSELRRKRRTNRLLIAMVVVFAVCWLP---LNLFNLLRDFEPLPqIDGRHFY---LIFLICHLIAMSSACVNPLLYG 283
                       330
                ....*....|
gi 20455271 391 LVRREFRKAL 400
Cdd:cd15203 284 WLNDNFRKEF 293
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
82-400 1.20e-39

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 144.66  E-value: 1.20e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMksmqgWRKSSI----NLFVTNLALTDFQFVLT-LPFWAVENALDfKWPFGKAMCK 156
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVV-----LRNKHMrtvtNYFLVNLAVADLLVSLFcMPLTLLENVYR-PWVFGEVLCK 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 157 IVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRtrghgrgdCCGRSlgdsccfSAKALCVWIWALAALASLPSAIFS 236
Cdd:cd14993  75 AVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARR--------VSTKR-------RARIIIVAIWVIAIIIMLPLLVVY 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 237 TTVKVMGEEL-------CLVRFPDKLLgrdrQFWLGLYHsqkVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGgaaVA 309
Cdd:cd14993 140 ELEEIISSEPgtitiyiCTEDWPSPEL----RKAYNVAL---FVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRG---SA 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 310 GGRPTGASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVP-FSQEYFLCQVYafPVSVCLAHSNSCLNPVL 388
Cdd:cd14993 210 NSTSSRRILRSKKKVARMLIVVVVLFALSWLP---YYVLSILLDFGPLSsEESDENFLLIL--PFAQLLGYSNSAINPII 284
                       330
                ....*....|..
gi 20455271 389 YCLVRREFRKAL 400
Cdd:cd14993 285 YCFMSKKFRRGF 296
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
82-397 2.52e-39

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 143.47  E-value: 2.52e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFkWPFGKAMCKIVSMV 161
Cdd:cd15092   1 VTIVVVYLIVCVVGLVGNCLVMYVILRHTK-MKTATNIYIFNLALADTLVLLTLPFQGTDIFLGF-WPFGNALCKTVIAI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFStTVKV 241
Cdd:cd15092  79 DYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHK---------------AKVVNVCIWALASVVGVPVMVMG-SAQV 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEEL-CLVRFPDKllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRA-AGTKggaavaggrptgASAR 319
Cdd:cd15092 143 EDEEIeCLVEIPTP-----QDYWDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLlSGSK------------EKDR 205
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPNQALTTWSILiKFNAVPFSQEYFLCqvyafpVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15092 206 NLRRITRLVLVVVAVFVGCWTPIQIFVLAQGL-GVQPSSETAVAILR------FCTALGYVNSSLNPVLYAFLDENFK 276
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
82-400 2.50e-38

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 140.43  E-value: 2.50e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFwAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15970   1 ILISFIYSVVCLVGLCGNSMVIYVILRYAK-MKTATNIYILNLAIADELLMLSVPF-LVTSTLLRHWPFGSLLCRLVLSV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15970  79 DAINMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPT---------------VAKMVNLGVWVFSILVILPIIIFSNTAPN 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 M-GEELCLVRFPDKllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLvrfIADRRAAGTKggaavAGGRPTGASARr 320
Cdd:cd15970 144 SdGSVACNMQMPEP-----SQRWLAVFVVYTFLMGFLLPVIAICLCYILI---IVKMRVVALK-----AGWQQRKRSER- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 lsKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQeyflcqvyafpVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15970 210 --KITLMVMMVVTVFVICWMPFYVVQLVSVFVGQHDATVSQ-----------LSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
82-398 3.80e-38

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 139.90  E-value: 3.80e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLmKSMQGWRKSSINLFVtNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15115   1 ILSLVVLSLTFLLGVPGNGLVIWV-AGLKMKRTVNTIWFL-NLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASAL--KSHRTRGHgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTV 239
Cdd:cd15115  79 IVLNMFASVFTLTAISLDRFLLVIKPVwaQNHRSVLL-----------------ACLLCGCIWILALLLCLPVFIYRTTV 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFpdkllgrdrqfwLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggrpTGASAR 319
Cdd:cd15115 142 TDGNHTRCGYDF------------LVAITITRAVFGFLLPLLIIAACYSFIAFRMQ------------------RGRFAK 191
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPNQALttwSILIKFNAVPFSQEYFLCQvyafPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15115 192 SQSKTFRVIIAVVVAFFVCWAPYHII---GILSLYGDPPLSKVLMSWD----HLSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
89-398 3.81e-38

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 140.29  E-value: 3.81e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  89 WVVCALGLAGN---LLVLYLMKSmqgwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMN 165
Cdd:cd15381   8 WIIFVLGTIENafvLIVFCLHKS----SCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdSCCfsAKALCVWIWALAALASLPSAIFSTTVKVMGEE 245
Cdd:cd15381  84 LYSSIYFLMMVSIDRYLALVKTMSSGRMRR-------------PAC--AKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYN 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 246 L--CLVRFPDkllgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavaggrptgaSARRLSK 323
Cdd:cd15381 149 ItaCVLDYPS-------EGWHVALNILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKFK-------------EIQTERK 208
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455271 324 VTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVyAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15381 209 ATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLISGCRWEDILDI-GTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
82-400 6.38e-38

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 139.42  E-value: 6.38e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGN---LLVLYLMKSMqgwrKSSINLFVTNLALTDFQFVLTLPFWAVENAldFKWPFGKAMCKIV 158
Cdd:cd15182   1 AFLPVFYYLVFLLSLLGNglvLWILVKYEKL----KTLTNIFILNLAISDLLFTFTLPFWASYHS--SGWIFGEILCKAV 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFSTT 238
Cdd:cd15182  75 TSIFYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRK---------------LRYASLVSVAVWVISILASLPELILSTV 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEELclvrfpdkLLGRDRQFWLGLYHSQKVLLgFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgasA 318
Cdd:cd15182 140 MKSDEDGS--------LCEYSSIKWKLGYYYQQNLF-FLIPLGIIVYCYVRILQTLMRTR-------------------T 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPnqalttWSILIKFNAVPfSQEYFLCQV-----YAFPVSVCLAHSNSCLNPVLYCLVR 393
Cdd:cd15182 192 MRKHRTVKLIFVIVLVFFLSWAP------YNIVIFLRSLK-DLTIPICECskqldYAFYICRNIAFSHCCLNPVFYVFVG 264

                ....*..
gi 20455271 394 REFRKAL 400
Cdd:cd15182 265 VKFRNHL 271
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
82-400 1.33e-37

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 138.95  E-value: 1.33e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMksmqgWR----KSSINLFVTNLALTDFQF-VLTLPFWAVENALdFKWPFGKAMCK 156
Cdd:cd15095   1 WLVPLIFAIIFLVGLAGNSLVIYVV-----SRhremRTVTNYYIVNLAVTDLAFlVCCVPFTAALYAT-PSWVFGDFMCK 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 157 IVSMVTSMNMYASVFFLTAMSVTRYHSVASALKS--HRTRghgRGdccgrslgdsccfsAKALCVWIWALAALASLPSAI 234
Cdd:cd15095  75 FVNYMMQVTVQATCLTLTALSVDRYYAIVHPIRSlrFRTP---RV--------------AVVVSACIWIVSFLLSIPVAI 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 235 FSTTVKVMGEE---LCLVRFPDKLLgrDRQFWLglYhsqKVLLGFVLPLGIIILCYLLLVRFIADRraagtkggAAVAGG 311
Cdd:cd15095 138 YYRLEEGYWYGpqtYCREVWPSKAF--QKAYMI--Y---TVLLTYVIPLAIIAVCYGLILRRLWRR--------SVDGNN 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 RPTGASARRLS---KVTKSVTIVVLSFFLCWLPNQALTTWSIL-IKFNAVPFsqeyflcqVYAFPVS-VCLAHSNSCLNP 386
Cdd:cd15095 203 QSEQLSERALRqkrKVTRMVIVVVVLFAICWLPNHVLNLWQRFdPNFPETYA--------TYALKIAaLCLSYANSAVNP 274
                       330
                ....*....|....
gi 20455271 387 VLYCLVRREFRKAL 400
Cdd:cd15095 275 FVYAFMGENFRKYF 288
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
82-400 1.81e-37

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 138.18  E-value: 1.81e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENAldFKWPFGKAMCKIVSMV 161
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRR-SRSSTDVYLLHLAIADLLFALTLPFWAVSVV--KGWIFGTFMCKLVSLL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsaKALCVWIWALAALASLPSAIFSTTVK- 240
Cdd:cd15178  78 QEANFYSGILLLACISVDRYLAIVHATRALTQKRHLV----------------KFVCAGVWLLSLLLSLPALLNRDAFKp 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 -VMGEELCLVRFPDKLLGRDRQFWLGLYHsqkvLLGFVLPLGIIILCYLLLVrfiadRRAAGTKGGaavaggrptgasar 319
Cdd:cd15178 142 pNSGRTVCYENLGNESADKWRVVLRILRH----TLGFLLPLVVMLFCYGFTI-----KTLLQTRSF-------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15178 199 QKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLITETCELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNN 278

                .
gi 20455271 400 L 400
Cdd:cd15178 279 L 279
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
82-400 6.72e-37

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 136.98  E-value: 6.72e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM---KSMqgwrKSSINLFVTNLALTDFQF-VLTLPFWAVENALdFKWPFGKAMCKI 157
Cdd:cd15207   1 VLFIVSYSLIFLLCVVGNVLVCLVVaknPRM----RTVTNYFILNLAVSDLLVgVFCMPFTLVDNIL-TGWPFGDVMCKL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15207  76 SPLVQGVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQ-----------------AFVIIVAIWVLALAIMIPQALVLE 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRFPDkllgrdrQFWLGLYHSQK-----VLLGFVLPLGIIILCYlllVRFIADRRAAGTKGGAAVAGGR 312
Cdd:cd15207 139 VKEYQFFRGQTVHICV-------EFWPSDEYRKAyttslFVLCYVAPLLIIAVLY---VRIGYRLWFKPVPGGGSASREA 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 313 PTGASARRLsKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYFLcQVYAFPVSVCLAHSNSCLNPVLYCLV 392
Cdd:cd15207 209 QAAVSKKKV-RVIKMLIVVVVLFALSWLP---LHTVTMLDDFGNLSPNQREVL-YVYIYPIAHWLAYFNSCVNPIVYGYF 283

                ....*...
gi 20455271 393 RREFRKAL 400
Cdd:cd15207 284 NRNFRKGF 291
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
86-400 7.37e-37

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 136.81  E-value: 7.37e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfkWPFGKAMCKIVSMVTSMN 165
Cdd:cd15174   5 PLYWLIFLVGAVGNSLVVLIYTYYRR-RKTMTDVYLLNLAIADLLFLCTLPFWATAASSG--WVFGTFLCKVVNSMYKIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgDSCCFSAKALCVWIWALAALASLPSAIFSTTVKVMGEE 245
Cdd:cd15174  82 FYSCMLLLTCISVDRYIAIVQATKAHNSK-------------NKRLLYSKLVCFFVWLLSTILSLPEILFSQSKEEESVT 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 246 LCLVRFPDKLLGRDRQFWLGLyhsqKVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrpTGASARRLS--K 323
Cdd:cd15174 149 TCTMVYPSNESNRFKVAVLAL----KVTVGFFLPFVVMVICYTLIIH---------------------TLLQAKRFQkhK 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 324 VTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSqeyflCQV-----YAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15174 204 ALKVIIAVVTVFVLSQLPYNSILLIKTINAYNITITD-----CATsqnldIAGQVTQSIAFLHSCLNPFLYVFVGVRFRK 278

                ..
gi 20455271 399 AL 400
Cdd:cd15174 279 DL 280
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
82-399 8.30e-37

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 136.66  E-value: 8.30e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVL-TLPFWAVENALDfKWPFGKAMCKIVSM 160
Cdd:cd15096   1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMR-STTNILILNLAVADLLFVVfCVPFTATDYVLP-TWPFGDVWCKIVQY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfSAKALCVwIWALAALASLPsAIFSTTVK 240
Cdd:cd15096  79 LVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERN--------------TLIAIVG-IWIVILVANIP-VLFLHGVV 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVR---FPDKLLGRDRQFWLGLYhsqkvLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaaVAGGRPTGAS 317
Cdd:cd15096 143 SYGFSSEAYSyctFLTEVGTAAQTFFTSFF-----LFSYLIPLTLICVLYMLMLRRLRRQK---------SPGGRRSAES 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLSKVTKSVTIVVLSFFLCWLPNQALttwsILIKFNAV-PFSQEYFLCQVyafpVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15096 209 QRGKRRVTRLVVVVVVVFAICWLPIHII----LLLKYYGVlPETVLYVVIQI----LSNCLAYGNSCVNPILYAFLSQNF 280

                ...
gi 20455271 397 RKA 399
Cdd:cd15096 281 RKA 283
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
82-398 9.59e-37

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 136.43  E-value: 9.59e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYlmksMQGWR-KSSIN-LFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVS 159
Cdd:cd15116   1 ILSMVIYSVVFVLGVLGNGLVIF----ITGFKmKKTVNtVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASALKS--HRTRGhgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15116  77 FLLFLNMFTSVFLLTVISIDRCISVVFPVWSqnHRSVR-----------------LASLVSLAVWVVAFFLSSPSFIFRD 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEE--LCLVRFPdklLGRDRQ----FWLGLYHSQKV-----LLGFVLPLGIIILCYLLLVRFIADRRAAGTKgga 306
Cdd:cd15116 140 TAPSQNNNkiICFNNFS---LSGDNSspevNQLRNMRHQVMtitrfLLGFLIPFTIIICCYAAIVLKLKRNRLAKSS--- 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 307 avaggrptgasarrlsKVTKSVTIVVLSFFLCWLPNQALTtwsiLIKFNAVPFSQEYFLCQVyafPVSVCLAHSNSCLNP 386
Cdd:cd15116 214 ----------------KPFKIIAAVIVTFFLCWAPYHILN----LLEMEATRSPASVFKIGL---PITSSLAFINSCLNP 270
                       330
                ....*....|..
gi 20455271 387 VLYCLVRREFRK 398
Cdd:cd15116 271 ILYVFMGQDFKK 282
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
86-399 4.99e-36

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 134.52  E-value: 4.99e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfKWPFGKAMCKIVSMVTSMN 165
Cdd:cd15094   5 VLYGLICIVGLVGNGLVIYVVLRYAK-MKTVTNLYILNLAVADECFLIGLPFLIVTMILK-YWPFGAAMCKIYMVLTSIN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdsCCFSAKALCVWIWALAALASLPSAIFSTTVKVMGEE 245
Cdd:cd15094  83 QFTSSFTLTVMSADRYLAVCHPIRSMRYR---------------TPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRY 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 246 LCLVRFPDKllgrdrqfwlGLYHSQKV------LLGFVLPLGIIILCYLLLVRFIadrRAAGTKggaavaggrpTGASAR 319
Cdd:cd15094 148 SCTIVWPDS----------SAVNGQKAftlytfLLGFAIPLLLISVFYTLVILRL---RTVGPK----------NKSKEK 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLS--KVTKSVTIVVLSFFLCWLPNqalttWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15094 205 RRShrKVTRLVLTVISVYIICWLPY-----WAFQVHLIFLPPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFR 279

                ..
gi 20455271 398 KA 399
Cdd:cd15094 280 KS 281
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
82-397 5.73e-36

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 134.50  E-value: 5.73e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLY---LMKSMqgwrKSSINLFVTNLALTDFQFVLTLPFWAVENALdfKWPFGKAMCKIV 158
Cdd:cd15172   1 VFVPVIYSLICVVGLIGNSLVVItyaFYKRT----KSMTDVYLLNMAIADILFVLTLPFWAVYEAH--QWIFGNFSCKLL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccGRSLGDSccfsaKALCVWIWALAALASLPSAIFSTT 238
Cdd:cd15172  75 RGIYAINFYSGMLLLACISVDRYIAIVQATKSFRLR--------SRTLAYS-----KLICAAVWLLAILISLPTFIFSEV 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VK--VMGEELCLVRFPDkllGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadRRAAGTKGGAAVaggrptga 316
Cdd:cd15172 142 YDfgLEEQYVCEPKYPK---NSTAIMWKLLVLSLQVSLGFFIPLLVMIFCYSFIIKTL--LQAQNSQRHKAV-------- 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 sarrlskvtKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLcqVYAFPVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15172 209 ---------RVVVAVVLVFLVCQVPYNIVLLIEAINLGEQQSCSSEKAV--AYAKTITECLAFFHCCLNPVLYAFIGVKF 277

                .
gi 20455271 397 R 397
Cdd:cd15172 278 R 278
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
83-399 1.17e-35

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 133.36  E-value: 1.17e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLY-LMKSMQGwrKSSINLFVTNLALTDFQFVL-TLPFWAVENALDfKWPFGKAMCKIVSM 160
Cdd:cd14971   2 IVPLFFALIFLLGLVGNSLVILvVARNKPM--RSTTNLFILNLAVADLTFLLfCVPFTATIYPLP-GWVFGDFMCKFVHY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd14971  79 FQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTP---------------RNALAASGCIWVVSLAVAAPVLALHRLRN 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEEL--CLVRFPDKllGRDRQFWLGLYhsqkvLLGFVLPLGIIILCYLLLVRFIadrraagtkgGAAVAGGRPTGASA 318
Cdd:cd14971 144 YTPGNRtvCSEAWPSR--AHRRAFALCTF-----LFGYLLPLLLICVCYAAMLRHL----------WRVAVRPVLSEGSR 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSqeyflcqVYAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd14971 207 RAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGPFPLTYAT-------YALRIWAHCLAYSNSAVNPVLYAFLSEHFRK 279

                .
gi 20455271 399 A 399
Cdd:cd14971 280 A 280
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
84-400 1.51e-35

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 133.34  E-value: 1.51e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLmkSMQGWRKS-SINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd14987   3 LSFFYIFIFVIGLLANSVVVWV--NLQAKRTGyETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVA-SALKSHRTRGHGRgdccgrslgdsccfsaKALCVWIWALAALASLPSAIFSTTVK- 240
Cdd:cd14987  81 SINLFGSIFFLTCMSVDRYLSVTlFGNTSSRRKKIVR----------------RIICVLVWLLAFVASLPDTYFLKTVTs 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 -VMGEELCLVRFPDKLLGRdrqfWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggrPTGASAR 319
Cdd:cd14987 145 pSNNETYCRSFYPEESFKE----WLIGMELVSIVLGFVIPFPIIAVFYFLLARAIS-----------------ASSDQER 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSKvtKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFS--QEYFLcqVYAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd14987 204 KSSR--KIIFSYVVVFLVCWLPYHTVVLLDILSFLHLIPFScqLENFL--YAALHVTQCFSLVHCCVNPILYSFINRNYR 279

                ...
gi 20455271 398 KAL 400
Cdd:cd14987 280 YEL 282
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
82-398 2.23e-35

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 132.81  E-value: 2.23e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVeNALDFKWPFGKAMCKIVSMV 161
Cdd:cd15090   1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTK-MKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGNILCKIVISI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15090  79 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPR---------------NAKIVNVCNWILSSAIGLPVMFMATTKYR 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPdkllgRDRQFWLGLYHSQKVLLGFVLPLGIIILCY-LLLVRFIADRRAAGTKggaavaggrptgASARR 320
Cdd:cd15090 144 QGSIDCTLTFS-----HPSWYWENLLKICVFIFAFIMPVLIITVCYgLMILRLKSVRMLSGSK------------EKDRN 206
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSqeyfLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15090 207 LRRITRMVLVVVAVFIVCWTP---IHIYVIIKALVTIPET----TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 277
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
82-400 1.76e-34

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 130.24  E-value: 1.76e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMksMQGWR-KSSINLFVTNLALTDFQFVLTLPFWAVENALDfKWPFGKAMCKIVSM 160
Cdd:cd15087   1 VALPVIYSVICAVGLTGNTAVIYVI--LRAPKmKTVTNVFILNLAIADDLFTLVLPINIAEHLLQ-QWPFGELLCKLILS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSttvK 240
Cdd:cd15087  78 IDHYNIFSSIYFLTVMSVDRYLVVLATVRSRRMPYRTYR-------------AAKIVSLCVWLLVTIIVLPFTVFA---G 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEEL----CLVRFPdkllgRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadRRAAGTKGGAAVaggrptgA 316
Cdd:cd15087 142 VYSNELgrksCVLSFP-----SPESLWFKASRIYTLVLGFAIPVSTICILYTMMLYKL--RNMRLNSNAKAL-------D 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 SARRlsKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPF--SQEYFLcqvyafpvsVCLAHSNSCLNPVLYCLVRR 394
Cdd:cd15087 208 KAKK--KVTLMVLVVLAVCLFCWTPFHLSTVVALTTDLPQTPLviGISYFI---------TSLSYANSCLNPFLYAFLDD 276

                ....*.
gi 20455271 395 EFRKAL 400
Cdd:cd15087 277 SFRKSF 282
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
82-398 3.94e-34

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 129.30  E-value: 3.94e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWrKSSINLFVTNLALTDFQFVLTLPFWAVENALDfKWPFGKAMCKIVSMV 161
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKM-KTATNIYIFNLALADALATSTLPFQSAKYLME-TWPFGELLCKAVLSI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTT-VK 240
Cdd:cd15089  79 DYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAK---------------AKLINICIWVLSSGVGVPIMVMAVTkTP 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCY-LLLVRFIADRRAAGTKggaavaggrptgASAR 319
Cdd:cd15089 144 RDGAVVCMLQFPSP-----SWYWDTVTKICVFIFAFVVPILVITVCYgLMILRLRSVRLLSGSK------------EKDR 206
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPNQALttwsiLIKFNAVPFSQEYFLCqVYAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15089 207 NLRRITRMVLVVVAAFIICWTPIHIF-----VIVWTLVDIDRRNPLV-VAALHLCIALGYANSSLNPVLYAFLDENFKR 279
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
82-400 8.41e-34

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 128.70  E-value: 8.41e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYlmksMQGWR--KSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVS 159
Cdd:cd15117   1 ILSLVIYSSAFVLGTLGNGLVIW----VTGFRmtRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASAL--KSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAalASLPSAIFST 237
Cdd:cd15117  77 TLVVFNLFASVFLLTLISLDRCVSVLWPVwaRNHRTPARA---------------ALVAVGAWLLALA--LSGPHLVFRD 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRF-PDKLLGRDRQFWLGLYHSQ-------KVLLGFVLPLGIIILCYLLLvrfiadrrAAGTKGGAAVA 309
Cdd:cd15117 140 TRKENGCTHCYLNFdPWNETAEDPVLWLETVVQRlsaqvitRFVLGFLVPLVIIGGCYGLI--------AARLWREGWVH 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 310 GGRPtgasarrlskvTKSVTIVVLSFFLCWLPNQA---LTTWSILIKFnavpfsQEYFLCQVYAFPVSVCLAHSNSCLNP 386
Cdd:cd15117 212 SSRP-----------FRVLTAVVAAFFLCWFPFHLvslLELVVILNQK------EDLNPLLILLLPLSSSLACVNSCLNP 274
                       330
                ....*....|....
gi 20455271 387 VLYCLVRREFRKAL 400
Cdd:cd15117 275 LLYVFVGRDFRERL 288
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
82-400 1.02e-33

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 128.24  E-value: 1.02e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMkSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15159   1 VLLPLFYSLILVFGLLGNTLALHVI-CQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15159  80 FYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKV---------------VRYICVFVWVLVFLQTLPLLFMPMTKEM 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCL--------VRFPDKLLGrdrqfwlglyhsqKVLLGFVLPLGIIILCYLLL---VRFIADRRAAGTKGGaavag 310
Cdd:cd15159 145 GGRITCMeypnfekiKRLPLILLG-------------ACVIGFGVPVGIILFCYSQItlkLCRTAKENPLTEKSG----- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 311 grptgasarRLSKVTKSVTIVVLSFFLCWLPNQAlttwsILIKFNAVPFSQEYFLCQVYAFPVS----VCLAHSNSCLNP 386
Cdd:cd15159 207 ---------HHKKACNVILLVLLVFVVCFSPYHL-----NIIQFMIRKLLYQPSCSELKAFKISlqitVCLMNLNCCLDP 272
                       330
                ....*....|....
gi 20455271 387 VLYCLVRREFRKAL 400
Cdd:cd15159 273 FIYFFACKGYKKKV 286
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
87-400 1.47e-33

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 127.58  E-value: 1.47e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  87 VYWVVCALGLAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfkWPFGKAMCKIVSMVTSMNM 166
Cdd:cd15177   6 VYLVVFVLGLVGNGLVL-ATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQG--WIFGNAMCKLIQGLYAINF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 167 YASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTTVKVMGEEL 246
Cdd:cd15177  83 YSGFLFLTCISVDRYVVIVRATSAHRLRPKTL-------------FYSVLTSLIVWLLSILFALPQLIYSRVENRSELSS 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 CLVRFPDKLLGRDRqfwlGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptGASARRLSKVtk 326
Cdd:cd15177 150 CRMIFPEVVSRTVK----GATALTQVVLGFAIPLIVMAVCYAAIGRTLLAAR----------------GWERHRALRV-- 207
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 327 sVTIVVLSFFLCWLPNQAlttwsILIKFNAVPFSQEYFLCQV-----YAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15177 208 -IAALVVAFVLFQLPYSV-----VLLLDTADLLATLELSCSQskrkdIALLVTSGLAYVRCCLNPLLYAFVGVRFRRDI 280
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
83-400 1.81e-33

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 127.56  E-value: 1.81e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSmQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfKWPFGKAMCKIVSMVT 162
Cdd:cd14999   1 AIGTVLSLMCVVGVAGNVYTLVVMCL-SMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLK-KWYFGDVGCRLLFSLD 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRtrghgrgdccgRSLGdsccfSAKALCVWIWALAALASLPSAIFSTTVKV- 241
Cdd:cd14999  79 FLTMHASIFTLTVMSTERYLAVVKPLDTVK-----------RSKS-----YRKLLAGVIWLLSLLLTLPMAIMIRLVTVe 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 ---MGEELCLVRFPDKLLGRdrqfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIadrraagtkggaAVAGGRPTGASA 318
Cdd:cd14999 143 dksGGSKRICLPTWSEESYK-------VYLTLLFSTSIVIPGLVIGYLYIRLARKY------------WLSQAAASNSSR 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLS--KVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNA-VPFSQeyfLCQVYAFPVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd14999 204 KRLPkqKVLKMIFTIVLVFWACFLP---FWIWQLLYLYSPsLSLSP---RTTTYVNYLLTCLTYSNSCINPFLYTLLTKN 277

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd14999 278 YKEYL 282
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
90-397 3.35e-33

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 126.84  E-value: 3.35e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMksMQGWRKSSI-NLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYA 168
Cdd:cd15380   9 AICFFGLLGNLFVLFVF--LLPRRRLTIaEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKANLFI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 169 SVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFST--TVKVMGEEL 246
Cdd:cd15380  87 SIFLVVAISQDRYRTLVHTMTSRRQRSRRQ---------------AQVICLLIWVFGGLLSIPTFLFRSvkHVPDLNISA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 CLVRFPDKLLGRDRQFWLGlyhsqkvLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavaggrptGASARRLSKVTK 326
Cdd:cd15380 152 CILLFPHEAWHFARRVELN-------IVGFLLPLAAIVFFNFHIIASLRERTEESRK-----------RCGGLKDTKATR 213
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20455271 327 SVTIVVLSFFLCWLPNQALTTWSILIKFNAVpfsQEYFLCQVYAFPVSVC--LAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15380 214 LILTLVLMFLVCWTPYHFFAFLDFLFQVEVI---QGCFWEEFIDLGLQLAnfFAFANSCLNPVIYVFAGKLFR 283
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
85-400 3.65e-33

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 126.85  E-value: 3.65e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  85 SVVYWVVCALGLAGNLLVLYLMksMQGWR-KSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTS 163
Cdd:cd15921   4 PTAYILIFILGLTGNSISVYVF--LSQYRsQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 164 MNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVKVMG 243
Cdd:cd15921  82 VNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHS---------------VAGIICGLIWILMGLASSPLLFAKSKQHDEG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 EELCLVrfpdklLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadrraagTKGGAAVAGGRPTgasaRRlsK 323
Cdd:cd15921 147 STRCLE------LAHDAVDKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNL-------LKPSPALGRTRPS----RR--K 207
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 324 VTKSVTIVVLSFFLCWLPNQALTTwSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15921 208 ACALIIISLGIFLVCFLPYHIVRT-IHLITERQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
86-400 3.81e-33

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 126.75  E-value: 3.81e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMksMQGW-RKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSM 164
Cdd:cd15157   5 TVYLIIFVLGVVGNGLSIYVF--LQPSkKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPsAIFSTTVKVMGE 244
Cdd:cd15157  83 NMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIK---------------YARILCAVIWIFVMAASSP-LLSKGTSKYNSQ 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 245 ELCLVRFPDKLlgrDRQFWLglyHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrpTGASARRLS-- 322
Cdd:cd15157 147 TKCLDLHPSKI---DKLLIL---NYIVLVVGFILPFCTLSICYILIIKALLKPR---------------VPQSKLRVShk 205
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 323 KVTKSVTIVVLSFFLCWLPNQALTTWSILIkfnavpFSQEYFLCQVY-AFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15157 206 KALLTIIITLILFLLCFLPYHILRTVHLMQ------WSEGQCNLRLHkAVVITLCLAAANSCLDPLLYYFAGENFKERL 278
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
80-404 9.94e-33

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 126.82  E-value: 9.94e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271   80 VRILISVVYWVVCALGLAGNLLVLYLMKSMQGwrKSSINLFVTNLALTDFQFVLTLPFWaVENALDFKWPFGKAMCKIVS 159
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIYVLTKTKI--KTPMDIYLLNLAVSDLLFVMTLPFQ-IYYYILFQWSFGEFACKIVS 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  160 MVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGdccgrslgdsccfsaKALCVWIWALAALASLPSAIFSTTV 239
Cdd:PHA03087 116 GLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYG---------------YIVSLVIWIISIIETTPILFVYTTK 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  240 KVMGEELCLVRFPDKllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggrpTGASAR 319
Cdd:PHA03087 181 KDHETLICCMFYNNK-----TMNWKLFINFEINIIGMLIPLTILLYCYSKILITLK------------------GINKSK 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  320 RLSKVTKSVTIVVLSFFLCWLPnqalttwsilikFNAVPFSQEYFLCQV-----------YAFPVSVCLAHSNSCLNPVL 388
Cdd:PHA03087 238 KNKKAIKLVLIIVILFVIFWLP------------FNVSVFVYSLHILHFksgckavkyiqYALHVTEIISLSHCCINPLI 305
                        330
                 ....*....|....*.
gi 20455271  389 YCLVRREFRKALKSLL 404
Cdd:PHA03087 306 YAFVSEFFNKHKKKSL 321
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
83-400 1.44e-32

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 125.22  E-value: 1.44e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLY-LMKSMQGWRKSSINLFVTNLALTDFQFVL-TLPFWAVENALDFkWPFGKAMCKIVSM 160
Cdd:cd15002   1 LVPILLGVICLLGFAGNLMVIGiLLNNARKGKPSLIDSLILNLSAADLLLLLfSVPFRAAAYSKGS-WPLGWFVCKTADW 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKShRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15002  80 FGHACMAAKSFTIAVLAKACYMYVVNPTKQ-VTIKQRR---------------ITAVVASIWVPACLLPLPQWLFRTVKQ 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPdkLLGRDRQFWLGLYHSqkvLLGFVLPLGIIILCYLLLVRFIADRRAAGTkggaavaggrpTGASARR 320
Cdd:cd15002 144 SEGVYLCILCIP--PLAHEFMSAFVKLYP---LFVFCLPLTFALFYFWRAYGQCQRRGTKTQ-----------NLRNQIR 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLcqvyafpVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15002 208 SRKLTHMLLSVVLAFTILWLPEWVAWLWLIHIKSSGSSPPQLFNV-------LAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
82-398 1.60e-32

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 125.07  E-value: 1.60e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfKWPFGKAMCKIVSMV 161
Cdd:cd15091   1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTK-MKTATNIYIFNLALADALVTTTMPFQSTVYLMN-SWPFGDVLCKIVISI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdsCCFSAKALCVWIWALAALASLPSAIF--STTV 239
Cdd:cd15091  79 DYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR---------------TPLKAKIINICIWLLSSSVGISAIVLggTKVR 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFPDkllgRDRQFWLGLYHSQKVLLGFVLPLGIIILCY-LLLVRFIADRRAAGTKggaavaggrptgASA 318
Cdd:cd15091 144 EDVDSTECSLQFPD----DDYSWWDTFMKICVFIFAFVIPVLIIIVCYtLMILRLKSVRLLSGSR------------EKD 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKF-NAVPFSQEYFLCqvyafpvsVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15091 208 RNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSVsHSTAAVSSYYFC--------IALGYTNSSLNPILYAFLDENFK 279

                .
gi 20455271 398 K 398
Cdd:cd15091 280 R 280
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
82-400 1.73e-32

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 124.58  E-value: 1.73e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfKWPFGKAMCKIVSMV 161
Cdd:cd15973   1 VVIQFIYALVCLVGLIGNSMVIFVILRYAK-MKTATNIYILNLAIADELFMLSVPFLAASAALQ-HWPFGSAMCRTVLSV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15973  79 DGINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPT---------------VAKMINICVWILSLLVISPIIIFADTATR 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEEL-CLVRFPDkllgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYLLLvrfIADRRAAGTKggaavaggrpTGASARR 320
Cdd:cd15973 144 KGQAVaCNLIWPH-------PAWSAAFVIYTFLLGFLLPVLAIGLCYILI---IGKMRAVALK----------AGWQQRR 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LS--KVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQeyflcqvyafpVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15973 204 KSekKITRMVLMVVTVFVICWMPFYVVQLLNLFLPRLDATVNH-----------ASLILSYANSCANPILYGFLSDNFRR 272

                ..
gi 20455271 399 AL 400
Cdd:cd15973 273 SF 274
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
82-397 2.67e-32

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 124.39  E-value: 2.67e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTD-FQFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15392   1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMR-TVTNYFIVNLALSDiLMAVFCVPFSFIALLILQYWPFGEFMCPVVNY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15392  80 LQAVSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQ-----------------ALLLIAVIWIFALATALPIAITSRLFE 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VM----GEELCLVRFPDKLLGRdrqfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagTKGGAAVAGGRPTGA 316
Cdd:cd15392 143 DSnascGQYICTESWPSDTNRY-------IYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKR---TPGEAENNRDQRMAE 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 SARRLSKVtksVTIVVLSFFLCWLPNQALTtwsILIKFNAVPFSQEYFLcqvYAFPVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15392 213 SKRKLVKM---MITVVAIFALCWLPLNILN---LVGDHDESIYSWPYIP---YLWLAAHWLAMSHCCYNPFIYCWMNAKF 283

                .
gi 20455271 397 R 397
Cdd:cd15392 284 R 284
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
86-400 8.19e-32

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 122.90  E-value: 8.19e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLmkSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMN 165
Cdd:cd15114   5 VLYAVVFLVGVPGNALVAWV--TGFEAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLILLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYhsvASALKSHRTRGHGRgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFSTTVKvmgee 245
Cdd:cd15114  83 MYASVLLLTAISADRC---LLVLRPVWCQNHRR------------ARLAWIACGAAWLLALLLTVPSFIYRRIHQ----- 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 246 lclVRFPDKLLgrdrqfwLGLYHSQ-----------KVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrpt 314
Cdd:cd15114 143 ---EHFPEKTV-------CVVDYGGstgvewavaiiRFLLGFLGPLVVIASCHGVLLVRTWSRR---------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 315 gasARRLSKVTKSVTIVVLSFFLCWLPNQALttwSILIKFNAVPfsQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRR 394
Cdd:cd15114 197 ---RQKSRRTLKVVTAVVVGFFLCWTPYHVV---GLIIAASAPN--SRLLANALKADPLTVSLAYINSCLNPIIYVVAGR 268

                ....*.
gi 20455271 395 EFRKAL 400
Cdd:cd15114 269 GFRKSL 274
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
83-400 8.35e-32

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 122.29  E-value: 8.35e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLT-LPFWAVENaLDFKWPFGKAMCKIVSMV 161
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLR-TVTNYFIVSLAVADLLVALLvMPFSAVYT-LLGYWPFGPVLCRFWIAL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAI-FSTTVK 240
Cdd:cd14967  79 DVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKR---------------ALIMIAAVWVYSLLISLPPLVgWRDETQ 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKLlgrdrqFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRFiadrraagtkggaavaggrptgasARR 320
Cdd:cd14967 144 PSVVDCECEFTPNKI------YVLVS-----SVISFFIPLLIMIVLYARIFRV------------------------ARR 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAvpfsqeYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd14967 189 ELKAAKTLAIIVGAFLLCWLP---FFIIYLVSAFCP------PDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
82-400 9.34e-32

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 122.88  E-value: 9.34e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMksMQGWRK-SSINLFVTNLALTDFQFVLTLPFWAVENALdfKWPFGKAMCKIVSM 160
Cdd:cd15180   1 VFLPVLYSLVFLLGLLGNGLVLAVL--LQKRRNlSVTDTFILHLALADILLLVTLPFWAVQAVH--GWIFGTGLCKLAGA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCgrslgdsccfsakalCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15180  77 VFKINFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLS---------------CLIVWLFCLLLSIPDFIFLEATK 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 V--MGEELCLVRFPDKllgrDRQFWLGL---YHsqkvLLGFVLPLGIIILCYLLLVRfiadRRAAGTKGgaavaggrptg 315
Cdd:cd15180 142 DprQNKTECVHNFPQS----DTYWWLALrllYH----IVGFLLPLAVMVYCYTSILL----RLLRSSQG----------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 asaRRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15180 199 ---FQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDRNCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVK 275

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd15180 276 FRRKL 280
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
82-400 1.01e-31

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 122.59  E-value: 1.01e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENAldFKWPFGKAMCKIVSMV 161
Cdd:cd15188   1 VFLPVFYTLVFLLGLAGNLLLFVVLLLYVPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVA--WHWVFGSFLCKFVSTL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15188  79 YTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTR---------------RKSLLVLVAVWVLSIALSVPDMVFVQTHHT 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 M-GEELCLVRFpdkllGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYlllvrfiadrraagTKGGAAVAGGRPTGasarr 320
Cdd:cd15188 144 NnGVWVCHADY-----GGHHTIWKLVFQFQQNLLGFLFPLLAMVFFY--------------SRIACVLTRLRPPG----- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPnqalttWSILIKFNAVPFSQEYFLCQV-----YAFPVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15188 200 QGRALRFVAALVVVFFVLWFP------YNLTLFLHSLQDLHVIGNCERsrhldYALQVTESLAFVHCCLNPLLYAFVSKR 273

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd15188 274 FRLYL 278
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
82-398 5.09e-31

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 120.65  E-value: 5.09e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVL----YLMKsmqgwRKSSINLFVTNLALTDFQFVLTLPFWAVENAldFKWPFGKAMCKI 157
Cdd:cd15173   1 YFLPCMYSVMFVTGLVGNSLVIviyiFYEK-----LRTLTDIFLVNLAVADLLFLCTLPFWAYSAA--HEWIFGTVMCKI 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTrgHGRGDCCGrslgdsccfsaKALCVWIWALAALASLPSAIFSt 237
Cdd:cd15173  74 TNGLYTINLYSSMLILTCITVDRFIVIVQATKAHNC--HAKKMRWG-----------KVVCTLVWVISLLLSLPQFIYS- 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRFPDKLLGRdrqfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADrraagtkggaavaggrptgAS 317
Cdd:cd15173 140 EVRNLSSKICSMVYPPDAIEV-------VVNIIQMTVGFFLPLLAMIICYSVIIKTLLH-------------------AK 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLSKVTKSVTIVVLSFFLCWLPNQALttwsILIKFNAVPFSQEYFLcqVYAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15173 194 GFQKHKSLKIIFVVVAVFILTQLPYNIM----KLIRTLHIENTDSTNF--KYAILITEAIAYLHACLNPILYAFVGVKFR 267

                .
gi 20455271 398 K 398
Cdd:cd15173 268 K 268
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
82-398 8.89e-31

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 119.93  E-value: 8.89e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVL-TLPFWAVENALDfKWPFGKAMCKIVSM 160
Cdd:cd15097   1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSGHNTTNLFILNLSVADLCFILfCVPFQATIYSLE-GWVFGSFLCKAVHF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKShrtrghgrgdccgRSLGDSCcfSAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15097  80 FIYLTMYASSFTLAAVSVDRYLAIRYPLRS-------------RELRTPR--NAVAAIALIWGLSLLFAGPYLSYYDLID 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDkllgRDRQfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdrRAAGTKGGAAvaggrptgASARR 320
Cdd:cd15097 145 YANSTVCMPGWEE----ARRK----AMDTCTFAFGYLIPVLVVSLSYTRTIKYLW--TAVDPLEAMS--------ESKRA 206
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNQALTtwsILIKFNAVPFSQEYFLCQVyafpVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15097 207 KRKVTKMIIIVTALFCLCWLPHHVVI---LCYLYGDFPFNQATYAFRL----LSHCMAYANSCLNPIVYALVSKHFRK 277
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
86-400 1.59e-30

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 119.48  E-value: 1.59e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLV----LYLMKsmqgwRKSSINLFVTNLALTDFQFVLTLPFWAVENALdfKWPFGKAMCKIVSMV 161
Cdd:cd15175   5 AMYSVICFLGLLGNGLViltyIYFKR-----LKTMTDIYLLNLALADILFLLTLPFWAASAAK--KWVFGEEMCKAVYCL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdSCCFSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15175  78 YKMSFFSGMLLLMCISIDRYFAIVQAASAHRHRS-------------RAVFISKVSSLGVWVLAFILSIPELLYSGVNNN 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLlgrdrQFWLGLYHSQKVlLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrpTGASARRL 321
Cdd:cd15175 145 DGNGTCSIFTNNKQ-----TLSVKIQISQMV-LGFLVPLVVMSFCYSVIIK---------------------TLLQARNF 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 --SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15175 198 ekNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKGNTTDCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFRND 277

                .
gi 20455271 400 L 400
Cdd:cd15175 278 L 278
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
82-397 3.35e-30

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 118.31  E-value: 3.35e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfkWPFGKAMCKIVSMV 161
Cdd:cd15176   1 LFLPVFYTIALVVGLAGNSLVVAIYAYYKK-LKTKTDVYILNLAVADLLLLFTLPFWAADAVNG--WVLGTAMCKITSAL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsakALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15176  78 YTMNFSCGMQFLACISVDRYVAITKATSRQFTGKHCW-----------------IVCLCVWLLAILLSIPDLVFSTVREN 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLLGRDRQFWLGLyhsqKVLLGFVLPLGIIILCYLLLVRFIadrraagtkggaavaggrpTGASARRL 321
Cdd:cd15176 141 SDRYRCLPVFPPSLVTSAKATIQIL----EVLLGFVLPFLVMVFCYSRVARAL-------------------SRTPNVKK 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSqeyflCQV-----YAFPVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15176 198 SRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYLLITD-----CSMsktldIAIQVTESIALFHSCLNPVLYVFMGASF 272

                .
gi 20455271 397 R 397
Cdd:cd15176 273 K 273
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
82-400 3.47e-30

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 118.59  E-value: 3.47e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLY-LMKSMQgwRKSSINLFVTNLALTD-FQFVLTLPFWAVENALDfKWPFGKAMCKIVS 159
Cdd:cd15389   1 ALLIVAYSIIIVISLFGNSLVCHvIFKNKR--MHTATNLFIVNLAVSDiLITLLNTPFTLVRFVNS-TWVFGKIMCHLSR 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfsaKALCVWIWALAALASLPSAIFSTTV 239
Cdd:cd15389  78 FAQYCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQG-----------------VVVIAIIWIMASCLSLPHAIYQKLV 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KV-----MGEELCLVRFPdkllGRDRQFWLGLYHSQKVLLgFVLPLGIIILCYLLLVRFIADRRAAGtkggaavAGGRPT 314
Cdd:cd15389 141 EFeysneRTRSRCLPSFP----EPSDLFWKYLDLATFILQ-YVLPLLIIGVAYTRVAKKLWLRNAIG-------DVTTEQ 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 315 GASARRLSKVT-KSVTIVVLSFFLCWLPnqaLTTWSILIKFNAV-PFSQEYFLCQvyafpvsvCLAHSNSCLNPVLYCLV 392
Cdd:cd15389 209 YVAQRRKKKKTiKMLMLVVLLFAICWLP---LNCYHVLLSSHPIrSNSALFFAFH--------WLAMSSTCYNPFIYCWL 277

                ....*...
gi 20455271 393 RREFRKAL 400
Cdd:cd15389 278 NDSFRSEL 285
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
82-400 4.03e-30

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 118.01  E-value: 4.03e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSmQGWRKSSINLFVTNLALTDFQFVLTLPFWAveNALDFKWPFGKAMCKIVSMV 161
Cdd:cd15186   1 IFLSIFYSLVFAFGLVGNLLVVLALTN-SGKSKSITDIYLLNLALSDLLFVATLPFWT--HYLINEWGLHNAMCKLTTAF 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKS--HRTRGHGRGDCCGrslgdsccfsakalcvwIWALAALASLPSAIFSTtv 239
Cdd:cd15186  78 FFIGFFGGIFFITVISIDRYLAIVLAANSmnNRTVQHGVTISLG-----------------VWAAAILVAVPQFMFTK-- 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 kvMGEELCLVRFPDKLlgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadrraagtkggaavaggrpTGASAR 319
Cdd:cd15186 139 --MKENECLGDYPEVL----QEIWPVLRNVELNFLGFLLPLLIMSYCYFRIIQTL-------------------FSCKNH 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPnqalttWSILIKFNAVPFSQEYFLCQV-----YAFPVSVCLAHSNSCLNPVLYCLVRR 394
Cdd:cd15186 194 KKARAIKLILLVVIVFFLFWTP------YNVMIFLETLKLYDFFPSCDMkkdlrLALSVTETIAFSHCCLNPLIYAFAGE 267

                ....*.
gi 20455271 395 EFRKAL 400
Cdd:cd15186 268 KFRRYL 273
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
82-400 4.47e-30

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 118.32  E-value: 4.47e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYL-MKSMQGWRKSSINLFvtNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15373   1 ILLPVSYGIVFVVGLVLNILALYVfLFRTKPWNASTTYMF--NLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTrGHGRgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15373  79 LFYTNLYCSILFLLCISVHRFLGVCYPVRSLRW-LKVR--------------YARIVSVVVWVIVLACQSPVLYFVTTSD 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKLLGRdrqfwLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAgtkggaavaggrpTGASARR 320
Cdd:cd15373 144 KGGNITCHDTSSPELFDQ-----FVVYSSVMLVLLFCVPFVVILVCYALMVRKLLKPSAG-------------TSTNSRS 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNQalTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15373 206 KKKSVKMIIIVLAVFILCFLPFH--VTRTLYYSFRSMDLSCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRSNL 283
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
82-400 9.45e-30

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 117.10  E-value: 9.45e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSmQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15160   1 IFLPVVYSFVFVVGLPANCLALWVLYL-QIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALAslPSAIFSTTVKV 241
Cdd:cd15160  80 FYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRR---------------FALKVSASIWVLELGT--HSVFLGHDELF 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEE---LCLVRFPdkllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadRRAAGTkggaavaggrptgaSA 318
Cdd:cd15160 143 RDEPnhtLCYEKYP-------MEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAV--RQSPSL--------------ER 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPNQALttwsILIKfnAVPFSQEYFLC----QVY-AFPVSVCLAHSNSCLNPVLYCLVR 393
Cdd:cd15160 200 EEKRKIIGLLLSIVVIFLLCFLPYHVV----LLVR--SVIELVQNGLCgfekRVFtAYQISLCLTSLNCVADPILYIFVT 273

                ....*..
gi 20455271 394 REFRKAL 400
Cdd:cd15160 274 EDVRQDL 280
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
82-400 2.63e-29

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 116.24  E-value: 2.63e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM---KSMQgwrkSSINLFVTNLALTDFQFVLT-LPFWAVENALDFKWPFGKAMCKI 157
Cdd:cd14997   1 VLVSVVYGVIFVVGVLGNVLVGIVVwknKDMR----TPTNIFLVNLSVADLLVLLVcMPVALVETWAREPWLLGEFMCKL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdCCGRslgdsccFSAKALCVwIWALAALASLPS---AI 234
Cdd:cd14997  77 VPFVELTVAHASVLTILAISFERYYAICHPLQAKYV-------CTKR-------RALVIIAL-IWLLALLTSSPVlfiTE 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 235 FSTTVKVMGEELCLVRFPDkllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAagTKGGAAVAGGRPT 314
Cdd:cd14997 142 FKEEDFNDGTPVAVCRTPA------DTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPA--LESRRADAANRHT 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 315 GASARRlskVTKSVTIVVLSFFLCWLPNQALTTWSILI-KFNAVPFSQEYFLCQVYAFPVSVCLahsNSCLNPVLYCLVR 393
Cdd:cd14997 214 LRSRRQ---VVYMLITVVVLFFVCLLPFRVVTLWIIFApDEDLQALGLEGYLNLLVFCRVMVYL---NSALNPILYNLMS 287

                ....*..
gi 20455271 394 REFRKAL 400
Cdd:cd14997 288 TKFRSAF 294
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
83-400 2.85e-29

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 116.12  E-value: 2.85e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLV-LYLMKSMQGWRKSSINLFvtNLALTDFQFVLTLPFWaVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15183   2 LLPPLYSLVFIIGVVGNVLVvLVLIQHKRLRNMTSIYLF--NLAISDLVFLFTLPFW-IDYKLKDDWIFGDAMCKFLSGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGrslgdsccfsakalcVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15183  79 YYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITS---------------IITWALAILASMPCLYFFKSQWE 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLLGRdrqfWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRraagtkggaavaggrptgaSARRL 321
Cdd:cd15183 144 FTHHTCSAHFPRKSLIR----WKRFQALKLNLLGLILPLLVMIICYTGIINILLRR-------------------PNEKK 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPnqalTTWSILIK-FNAVPFSQEYFLCQV--YAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15183 201 AKAVRLIFVITLLFFLLWTP----YNLAAFVSaFQDVLFTPSCEQSQQldLALQVTEVIAYTHCCVNPVIYVFVGERFRK 276

                ..
gi 20455271 399 AL 400
Cdd:cd15183 277 YL 278
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
82-398 3.56e-29

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 115.97  E-value: 3.56e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM---KSMQgwrkSSINLFVTNLALTD-FQFVLTLPFwAVENALDFKWPFGKAMCKI 157
Cdd:cd15393   1 VLLSILYGIISLVAVVGNFLVIWVVaknRRMR----TVTNIFIANLAVADiIIGLFSIPF-QFQAALLQRWVLPRFMCPF 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15393  76 CPFVQVLSVNVSVFTLTVIAVDRYRAVIHPLKARCSK-----------------KSAKIIILIIWILALLVALPVALALR 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRFPDKLLGRDRQFWLgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGgrptgaS 317
Cdd:cd15393 139 VEELTDKTNNGVKPFCLPVGPSDDWWK-IYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQDVRDDE------I 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILI-KFNAVPFSQEYFLCqvyafpvSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15393 212 LKNKKKVIKMLIIVVALFALCWLPLQTYNLLNEIKpEINKYKYINIIWFC-------SHWLAMSNSCYNPFIYGLYNEKF 284

                ..
gi 20455271 397 RK 398
Cdd:cd15393 285 KR 286
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
82-400 3.77e-29

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 115.65  E-value: 3.77e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWrksSIN-LFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15120   1 VLIAVALFVTFLVGLVVNGLYLWVLGFKMRR---TVNtLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASAL--KSHRTRGHGrgdccgrslgdsccfSAKALCVWIwaLAALASLPSAIFSTT 238
Cdd:cd15120  78 TLSVGMFTSVFLLTAISLDRYLLTLHPVwsRQHRTNRWA---------------SAIVLGVWI--SAILLSIPYLAFRET 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 -VKVMGEELCLVRF--PDKLLGRDRQFWLGLYH----SQKVLLGFVLPLGIIILCYLLLVRFIADRRAAgtkggaavagg 311
Cdd:cd15120 141 rLDEKGKTICQNNYalSTNWESAEVQASRQWIHvamfVFRFLLGFLLPFLIITFCYVRMALKMKERGLA----------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 rptgasarRLSKVTKSVTIVVLSFFLCWLPNQALTtwSILIKFNAVPFSQEYFLCqvyafpVSVCLAHSNSCLNPVLYCL 391
Cdd:cd15120 210 --------RSSKPFKVMFTAVVSFFVCWLPYHLHS--GLVLTRGRPPSLTDITLL------LTVGTTCFNTCFTPVLYLF 273

                ....*....
gi 20455271 392 VRREFRKAL 400
Cdd:cd15120 274 VGENFKKVL 282
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
82-400 7.34e-29

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 114.95  E-value: 7.34e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSsINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15194   1 GFLPILYCLVFLVGAVGNAILMGALVFKRGVRRL-IDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15194  80 ISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTK---------------HNAKVCCTCVWMLSCLLGLPTLLSRELKKY 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLvrfPDKLLGRDRQFWLglyhsQKVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavAGGRPTGASARRL 321
Cdd:cd15194 145 EEKEYCN---EDAGTPSKVIFSL-----VSLIVAFFLPLLSILTCYCTIIWKLC-------------HHYQKSGKHQKKL 203
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVyAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15194 204 RKSIKIVFIVVAAFVFSWMPFNLFKALAIASGLQVEVTCLPYTLAQL-GMEVSAPLAFANSCANPFIYYFFDRYIRRAI 281
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
82-400 7.65e-29

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 114.91  E-value: 7.65e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15339   1 VILPSFIGILCSTGLVGNILVLFTIIRSR--KKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15339  79 DTCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSK---------------TIRINLLVWAASFILVLPVWVYAKVIKF 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 M-GEELCLVrfpdKLLGRDRQFWLGLYHSqkvLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVaggrpTGASARR 320
Cdd:cd15339 144 RdGLESCAF----NLTSPDDVLWYTLYQT---ITTFFFPLPLILICYILILCYTWEMYRKNKKAGRYN-----TSIPRQR 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFsqeyflcqVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15339 212 VMRLTKMVLVLVGVFLVSAAPYHVIQLVNLSVSQPTLAF--------YVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
82-400 2.52e-28

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 113.37  E-value: 2.52e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15202   1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMR-TVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGrslgdsccfsakalcvwIWALAALASLPSAIFSTTVKV 241
Cdd:cd15202  80 QYCSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAV-----------------IWTLALAFALPHAICSKLETF 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEE-----LCLVRFPDkllgRDRQFWLgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGgrptga 316
Cdd:cd15202 143 KYSEdivrsLCLEDWPE----RADLFWK-YYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDATTERYFA------ 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 SARRLSKVTKSVTIVVLSFFLCWLPNQALttwsiLIKFNAVPFSQEYFLCQVY-AFpvsVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15202 212 LRRKKKKVIKMLMVVVVLFALCWLPFNIY-----VLLLSSKPDYLIKTINAVYfAF---HWLAMSSTCYNPFIYCWLNER 283

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd15202 284 FRIEF 288
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
85-400 5.50e-28

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 112.53  E-value: 5.50e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  85 SVVYWVVCALGLAGNLLVLY-LMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTS 163
Cdd:cd15158   4 STLYSVITVFGLVGNGFALYvLIKTYR--QKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 164 MNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVMG 243
Cdd:cd15158  82 VNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKK---------------ARIVCVGIWIFVTLTSSPFLMSGSHDTETN 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 EELCLvRFPDKLLGRDRqfwLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavagGRPTGASARRLsk 323
Cdd:cd15158 147 KTKCF-EPPQSNQQLTK---LLVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKARK-------QQSSRKKAIRM-- 213
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 324 vtksVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQvYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15158 214 ----IIIVLLAFLVSFMPYHIQRTIHLHFLSRKDSTCEEVLYMQ-KSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
80-398 8.28e-28

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 112.11  E-value: 8.28e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  80 VRILisvVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVL-TLPFWAVENAlDFKWPFGKAMCKIV 158
Cdd:cd15195   2 VRVL---VTWVLFVISAAGNLTVLIQLFRRRR-AKSHIQILIMHLALADLMVTFfNMPMDAVWNY-TVEWLAGDLMCRVM 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsaKALCVwIWALAALASLPSAIFSTT 238
Cdd:cd15195  77 MFLKQFGMYLSSFMLVVIALDRVFAILSPLSANQARKRVK----------------IMLTV-AWVLSALCSIPQSFIFSV 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEELCLVRFPDKLLGRDRQFWLgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASA 318
Cdd:cd15195 140 LRKMPEQPGFHQCVDFGSAPTKKQER-LYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRARDTPISNRRRSRTNSLE 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYflcQVYAFpvsvCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15195 219 RARMRTLRMTALIVLTFIVCWGPYYVLGLWYWFDKESIKNLPPAL---SHIMF----LLGYLNPCLHPIIYGVFMKEIRN 291
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
83-398 1.27e-27

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 111.59  E-value: 1.27e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLM---KSMQgwrkSSINLFVTNLALTDFQFVLT-LPFWAVENALDfKWPFGKAMCKIV 158
Cdd:cd15927   2 VVPILFALIFLVGVLGNGTLILIFlrnKSMR----NVPNIFILSLALGDLLLLLTcVPFTSTIYTLD-SWPFGEFLCKLS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRtrghgrgdccGRSLGDSCCfsaKALCVWIwaLAALASLPSAIFSTT 238
Cdd:cd15927  77 EFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHR----------SQATRRTLV---TAASIWI--VSILLAIPEAIFSHV 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEElclvRFPDKLLGRDRQFWLGLYHSQKVLLGF----VLPLGIIILCYLLLVR-FIADRRAAGTKGGAAVAggrp 313
Cdd:cd15927 142 VTFTLTD----NQTIQICYPYPQELGPNYPKIMVLLRFlvyyLIPLLIIGVFYVLMARhLIRSTRNIGSGQNQAAQ---- 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 314 TGASARRlsKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFpvsvCLAHSNSCLNPVLYCLVR 393
Cdd:cd15927 214 RQIEARK--KVAKTVLAFVVLFAVCWLPRHVFMLWFHFAPNGLVDYNAFWHVLKIVGF----CLSFINSCVNPVALYLLS 287

                ....*
gi 20455271 394 REFRK 398
Cdd:cd15927 288 GSFRR 292
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
86-391 2.81e-27

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 110.59  E-value: 2.81e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMkSMQGWRKSSINLFVTNLALTDFQF----VLTLPFWAVENAldfkWPFGKAMCKIVSMV 161
Cdd:cd15197   5 ATLWVLFVFIVVGNSSVLFAL-WMRKAKKSRMNFFITQLAIADLCVglinVLTDIIWRITVE----WRAGDFACKVIRYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAI-FSTTVK 240
Cdd:cd15197  80 QVVVTYASTYVLVALSIDRYDAICHPMNFSQSGRQ-----------------ARVLICVAWILSALFSIPMLIiFEKTGL 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKLlgrdrqFWLgLYHSQKVLLGFVLPLGIIILCYLLLVR--------FIADRRAAGTKGGAAVAGGR 312
Cdd:cd15197 143 SNGEVQCWILWPEPW------YWK-VYMTIVAFLVFFIPATIISICYIIIVRtiwkkskiQVTINKAGLHDGSSRRSSSR 215
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 313 ptGASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYFlcqvYAFPVSVCLAHSNSCLNPVLYCL 391
Cdd:cd15197 216 --GIIPRAKIKTIKMTFVIVTVFIICWSP---YFVFDLLDVFGLLPRSKTKI----AAATFIQSLAPLNSAINPLIYCL 285
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
82-400 2.92e-27

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 110.37  E-value: 2.92e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM-KSMQgwRKSSINLFVTNLALTDF-QFVLTLPFWAVENALDfKWPFGKAMCKIVS 159
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFlKKKK--LRTPLNLFLLNLALADLlMSVVGYPLSFYSNLSG-RWSFGDPGCVIYG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgrslgdSCCFSAKALCV-WIWALAaLASLPSAIFSTT 238
Cdd:cd14969  78 FAVTFLGLVSISTLAALAFERYLVIVRPLKAFRL---------------SKRRALILIAFiWLYGLF-WALPPLFGWSSY 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEELCLVRFPDKLLgRDRQFWLGLYhsqkvLLGFVLPLGIIILCYLLLVRFIadRRAagTKGGAAVAGGRPTGASA 318
Cdd:cd14969 142 VPEGGGTSCSVDWYSKDP-NSLSYIVSLF-----VFCFFLPLAIIIFCYYKIYRTL--RKM--SKRAARRKNSAITKRTK 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPfsqeyflcqVYAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd14969 212 KAEKKVAKMVLVMIVAFLIAWTPYAVVSLYVSFGGESTIP---------PLLATIPALFAKSSTIYNPIIYVFMNKQFRR 282

                ..
gi 20455271 399 AL 400
Cdd:cd14969 283 AL 284
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
82-398 3.92e-27

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 110.25  E-value: 3.92e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYL-MKSMQGWRKSSINLFvtNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15968   1 ILLPICYSFVFLLGLPLNSVVLTRcCRHTKAWTRTAIYMV--NLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15968  79 LFYFNLYGSILFLTCISVHRYLGICHPMRPWHKETRR---------------AAWLTCVLVWILVFAQTLPILIFARTGI 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKLLGRDRQFWLGLYhsqkvLLGFVLPLGIIILCYLLLVRFIAdrRAAGtkggaavaGGRPTGASARR 320
Cdd:cd15968 144 IRNRTVCYDLAPPALFPHYVPYGMALT-----VSGFLLPFSIILWCYCLVVRTLC--RTLG--------PAEPPAQARRR 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 lsKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFN-AVPfsqeyflCQVY-----AFPVSVCLAHSNSCLNPVLYCLVRR 394
Cdd:cd15968 209 --KSIRTIVTVTLLFALCFLPFHITRTIYLAVRVTpGVP-------CHVLeavaaCYKITRPLASANSVLNPLLYFLTKK 279

                ....
gi 20455271 395 EFRK 398
Cdd:cd15968 280 KFGR 283
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
87-391 5.31e-27

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 110.16  E-value: 5.31e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  87 VYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTD----FQFVLTLPFWAvenaLDFKWPFGKAMCKIVSMVT 162
Cdd:cd14986   6 VLGVLFVFTLVGNGLVILVLRRKRK-KRSRVNIFILNLAIADlvvaFFTVLTQIIWE----ATGEWVAGDVLCRIVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKS--HRTRghgrgdccgrslgdsccfsAKALCVWIWALAALASLPSA-IFSTTV 239
Cdd:cd14986  81 VVGLFASTYILVSMSLDRYQAIVKPMSSlkPRKR-------------------ARLMIVVAWVLSFLFSIPQLvIFVERE 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFPDkllgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAA----VAGGRPTG 315
Cdd:cd14986 142 LGDGVHQCWSSFYT-------PWQRKVYITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRPIAptamSCRSVSCV 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 ASARRL-----SKVTKSVTIVVLSFFLCWLPNQALTTWSIlikfnavpfsqeYFLCQ---VYAFPVSVCLAHSNSCLNPV 387
Cdd:cd14986 215 SSRVSLisrakIKTIKMTLVIILAFILCWTPYFIVQLLDV------------YAGMQqleNDAYVVSETLASLNSALNPL 282

                ....
gi 20455271 388 LYCL 391
Cdd:cd14986 283 IYGF 286
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
82-400 2.01e-26

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 107.96  E-value: 2.01e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLTLPFWAvENALDfKWPFGKAMCKIVSMV 161
Cdd:cd15187   1 LFLPVLYCLLFVFGLLGNSLVIWVLVACKKLR-SMTDVYLLNLAASDLLFVFSLPFQA-YYLLD-QWVFGNAMCKIVSGA 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGdccgrslgdsccfsaKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15187  78 YYIGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHG---------------TILSLALWLVAILASVPLLVFYQVASE 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLLGrdrqfWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadrraagtkggaavaggrpTGASARRL 321
Cdd:cd15187 143 DGRLQCIPFYPGQGNS-----WKVFTNFEVNILGLLIPFSILIFCYHNILRNL-------------------RRCHNQNK 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQA---LTTWSILIKFNAVPFSQEYflcqVYAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15187 199 TKAIKLVFIVVIVFFLFWTPFNVvlfLDSLHSLHIIDGCQNSQRL----TLALHLTETISFTHCCLNPVIYAFVGEKFKK 274

                ..
gi 20455271 399 AL 400
Cdd:cd15187 275 HL 276
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
82-397 2.36e-26

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 107.92  E-value: 2.36e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMkSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15162   1 VFLPAVYTLVFVVGLPANGMALWVL-LFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15162  80 FYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRY---------------ALGTCLAIWLLALLVTLPLYLVKQTIFL 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 --MGEELCLVRFPDKLLGRDRQFwlglYHSQKVLLGFVLPLGIIILCYLLLVRFIADrraagtkggaavaggRPTGASAR 319
Cdd:cd15162 145 paLDITTCHDVLPEQLLVGDWFY----YFLSLAIVGFLIPFILTASCYVATIRTLAA---------------LEDENSEK 205
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLP-NQALTTWSILIKFNAVpfSQEYFlcqvyAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15162 206 KKKRAIKLAATVLAIFIICFAPsNLLLLAHYSLISSSGT--GHLYF-----AYLLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
82-398 3.75e-26

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 107.52  E-value: 3.75e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVL---YLMKSMQGwrksSINLFVTNLALTDFQFVL-TLPFwAVENALDFKWPFGKAMCKI 157
Cdd:cd14992   1 IILGVALVVIILVSVVGNFIVIaalARHKNLRG----ATNYFIASLAISDLLMALfCTPF-NFTYVVSLSWEYGHFLCKI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFST 237
Cdd:cd14992  76 VNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTT---------------TVIIIITIWVVSLLLAIPQLYYAT 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaaVAGGRPTGAS 317
Cdd:cd14992 141 TEVLFSVKNQEKIFCCQIPPVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRK---------VPGFSIKEVE 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLS---KVTKSVTIVVLSFFLCWLPNQAlttwsilikFNAVP-----FSQEYFLCQVYAFpvSVCLAHSNSCLNPVLY 389
Cdd:cd14992 212 RKRLKckrRVIKMLVCVVVLFVICWLPFHL---------FFLLRdffplIMKEKHTLQVYYF--LHWIAMSNSMYNPIIY 280

                ....*....
gi 20455271 390 CLVRREFRK 398
Cdd:cd14992 281 VTLNNNFRK 289
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
83-400 4.81e-26

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 106.76  E-value: 4.81e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWrKSSINLFVTNLALTDFQFVLTLPFWAVENALDfkWPFGKAMCKIVSMVT 162
Cdd:cd15184   2 LLPPLYSLVFIFGFVGNMLVVLILINCKKL-KSMTDIYLLNLAISDLLFLLTLPFWAHYAANE--WVFGNAMCKLLTGLY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRY----HSVaSALKShRTRGHGrgdccgrslgdsccfsaKALCVWIWALAALASLPSAIFSTT 238
Cdd:cd15184  79 HIGFFSGIFFIILLTIDRYlaivHAV-FALKA-RTVTFG-----------------VVTSVVTWVVAVFASLPGIIFTKS 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEELCLVRFPDKllgrDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgaSA 318
Cdd:cd15184 140 QKEGSHYTCSPHFPPS----QYQFWKNFQTLKMNILGLVLPLLVMIICYSGILKTLLRCR------------------NE 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPnqalttWSILIKFNAVpfsQEYFL---CQVY-----AFPVSVCLAHSNSCLNPVLYC 390
Cdd:cd15184 198 KKRHKAVRLIFTIMIVYFLFWAP------YNIVLLLNTF---QEFFGlnnCSSSnrldqAMQVTETLGMTHCCINPVIYA 268
                       330
                ....*....|
gi 20455271 391 LVRREFRKAL 400
Cdd:cd15184 269 FVGEKFRSYL 278
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
82-400 1.25e-25

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 105.63  E-value: 1.25e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd14988   1 VVLFILYLVIFVVGLVENVLVIWVNWHRWG-SKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd14988  80 YFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRI---------------RRALCAGIWVLSAIIPLPEVVHMQLLDG 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MgEELCLVRFPDKLLGRdrqfWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadRRAagtkggaavagGRPtgaSARRL 321
Cdd:cd14988 145 V-EPMCLFLAPFETYDE----WALAVSLLTLIIGFLIPFSIIAVFNVLTARYI--RTA-----------GRP---ESRRH 203
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 322 SKVtksVTIVVLSFFLCWLPNQaLTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd14988 204 CLL---IYAYILVFVVCWLPYH-VTLLLLTLHGSHISLHCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
82-400 1.39e-25

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 105.66  E-value: 1.39e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM--KSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVS 159
Cdd:cd15338   1 VIMPSVFGVICFLGIIGNSIVIYTIvkKSKFRCQQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLIT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdSCCFSAKALCVwIWALAALASLPSAIFSTTV 239
Cdd:cd15338  81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIR--------------TPRVAVAVICL-VWILSLLSITPVWMYAGLM 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEEL-CLVRFPDKllgRDRQFWLGLYhsqKVLLGFVLPLGIIILCYLLLVRFIADRRAAgtkggaavaggRPTGASA 318
Cdd:cd15338 146 PLPDGSVgCALLLPNP---ETDTYWFTLY---QFFLAFALPLVVICVVYFKILQNMASTVAP-----------LPQRSLR 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFsqeyflcqVYAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15338 209 VRTKKVTRMAVAICLAFFICWAPFYILQLAHLSIDRPSLAF--------LYAYNVAISMGYANSCINPFLYIMLSETFKR 280

                ..
gi 20455271 399 AL 400
Cdd:cd15338 281 QF 282
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
82-400 1.46e-25

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 105.66  E-value: 1.46e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYL-MKSMQGWRKSSINLFvtNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15374   1 ILLPVSYGLVFVVGLPLNATALWLfIKRMRPWNPTTVYMF--HLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRtRGHGRgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15374  79 LFYANLYCSILFLTCISVHRYVGICHPIRALR-WVKPR--------------HAYLICASVWLVVTVCLVPNLIFVTTSR 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKLLGRDRQfwlglYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaaVAGGRPTGASARR 320
Cdd:cd15374 144 KDNITLCHDTTRPEEFDHYVH-----YSSAVMVLLFGIPCLVIVVCYGLMARRLCKPR---------VGSSRQQGPSSKK 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 lsKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPfsqeyflCQV-----YAFPVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15374 210 --RSLKTIIMVLTVFAICFVPFHITRTLYYVARLLKAD-------CDTlniinVTYKVTRPLASANSCLDPILYFLAGDK 280

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd15374 281 YRRRL 285
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
83-398 1.52e-25

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 105.77  E-value: 1.52e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLL---VLYLMKSMQgwrkSSINLFVTNLALTDFQFVLT-LPFWAVENALDfKWPFGKAMCKIV 158
Cdd:cd15123   2 AIYVTYAVIISVGILGNAIlikVFFKIKSMQ----TVPNIFITSLAFGDLLLLLTcVPVDATRYIAD-TWLFGRIGCKLL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgRSLGDSCCfsaKALCVWIwaLAALASLPSAIFSTT 238
Cdd:cd15123  77 SFIQLTSVGVSVFTLTVLSADRYRAIVKPLELQTS----------DAVLKTCC---KAGCVWI--VSMLFAIPEAVFSDL 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 V------KVMGEELClVRFP--DKLLGRdrqfwlglYHSQKVLLGF-VLPLGIIILCYLLLVRFIAdrRAAGTKGGAAVA 309
Cdd:cd15123 142 YsfrdpeKNTTFEAC-APYPvsEKILQE--------IHSLLCFLVFyIIPLSIISVYYFLIARTLY--KSTFNMPAEEHS 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 310 GGRPTGASARRLSkvtKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYafpvSVCLAHSNSCLNPVLY 389
Cdd:cd15123 211 HARKQIESRKRVA---KTVLVLVALFAFCWLPNHILYLYRSFTYHTSVDSSAFHLIATIF----SRVLAFSNSCVNPFAL 283

                ....*....
gi 20455271 390 CLVRREFRK 398
Cdd:cd15123 284 YWLSKSFRQ 292
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
84-400 2.43e-25

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 104.67  E-value: 2.43e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLT-LPFWAVENALdFKWPFGKAMCKIVSMVT 162
Cdd:cd15001   2 VIIVYVITFVLGLIGNSLVIFVVARFRR-MRSVTNVFLASLATADLLLLVFcVPLKTAEYFS-PTWSLGAFLCKAVAYLQ 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPsAIFSTTVKVM 242
Cdd:cd15001  80 LLSFICSVLTLTAISIERYYVILHPMKAKSFCTIGR---------------ARKVALLIWILSAILASP-VLFGQGLVRY 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 GEE------LCLVRFPDKLLGRdrqfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFiadrraagtkggaavaggrptga 316
Cdd:cd15001 144 ESEngvtvyHCQKAWPSTLYSR-------LYVVYLAIVIFFIPLIVMTFAYARDTRK----------------------- 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 sarrlsKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAV---PFSQEYFLCQVYAfpvsvCLAHSNSCLNPVLYCLVR 393
Cdd:cd15001 194 ------QVIKMLISVVVLFAVCWGP---LLIDNLLVSFDVIstlHTQALKYMRIAFH-----LLSYANSCINPIIYAFMS 259

                ....*..
gi 20455271 394 REFRKAL 400
Cdd:cd15001 260 KNFRSSF 266
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
82-400 3.22e-25

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 105.11  E-value: 3.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM---KSMQgwrkSSINLFVTNLALTDFQF-VLTLPFWAVENALDFKWPFGKAMCKI 157
Cdd:cd15134   1 IPITIIYGIIFVTGVVGNLCTCIVIarnRSMH----TATNYYLFSLAVSDLLLlILGLPFELYTIWQQYPWVFGEVFCKL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15134  77 RAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSR---------------AIRIIIAIWIIAFVCALPFAIQTR 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKV--LLGFVLPLGIIILCYLLLVRFIAdRRAAGTKGGAAVAGGRPTG 315
Cdd:cd15134 142 IVYLEYPPTSGEALEESAFCAMLNEIPPITPVFQLstFLFFIIPMIAIIVLYVLIGLQLR-RSTLLRRGQRSVSGGRRSS 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 ASARRlskVTKSVTIVVLSFFLCWLPNQALTTWSILIKfNAVPFSQEYFlcqVYAFPVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15134 221 QSRRT---VLRMLVAVVVAFFICWAPFHAQRLLTVYAK-NMTPPYLFIN---RILFYISGVLYYVSSTVNPILYNVMSAK 293

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd15134 294 YRQAF 298
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
82-397 3.30e-25

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 104.68  E-value: 3.30e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM---KSMQgwrkSSINLFVTNLALTDfqfVLTLPFWAVEN---ALDFKWPFGKAMC 155
Cdd:cd15390   1 VLWSIVFVVMVLVAIGGNLIVIWIVlahKRMR----TVTNYFLVNLAVAD---LLISAFNTVFNftyLLYNDWPFGLFYC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 156 KIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIF 235
Cdd:cd15390  74 KFSNFVAITTVAASVFTLMAISIDRYIAIVHPLRPRLSRR-----------------TTKIAIAVIWLASFLLALPQLLY 136
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 STTVKVM-----GEELCLVRFPDKLLGRDRQFwlglYHSQKVLLGFVLPLGIIILCYLLL-VRFIADRraagtkggaavA 309
Cdd:cd15390 137 STTETYYyytgsERTVCFIAWPDGPNSLQDFV----YNIVLFVVTYFLPLIIMAVAYTRVgVELWGSK-----------T 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 310 GGRPTGASARRL---SKVTKSVTIVVLSFFLCWLPNQA--LTTWsILIKFNAVPFSQEYFLCqVYafpvsvCLAHSNSCL 384
Cdd:cd15390 202 IGENTPRQLESVrakRKVVKMMIVVVVIFAICWLPYHLyfILTY-LYPDINSWKYIQQIYLA-IY------WLAMSNSMY 273
                       330
                ....*....|...
gi 20455271 385 NPVLYCLVRREFR 397
Cdd:cd15390 274 NPIIYCWMNKRFR 286
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
82-399 4.03e-25

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 104.74  E-value: 4.03e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDF-QFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLR-TTTNYYLFSLAVSDLlILLVGLPVELYNFWWQYPWAFGDGGCKLYYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd14979  80 LFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRR---------------VKRFILAIWLVSILCAIPILFLMGIQY 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDK-LLGRDRQFWLGLYHSQkVLLGFVLPLGIIILCYLLLVRFIADRR--AAGTKGGAAVAGGRPTGAS 317
Cdd:cd14979 145 LNGPLPGPVPDSAVcTLVVDRSTFKYVFQVS-TFIFFVLPMFVISILYFRIGVKLRSMRniKKGTRAQGTRNVELSLSQQ 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRlsKVTKSVTIVVLSFFLCWLPNQALTtwsiLIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd14979 224 ARR--QVVKMLGAVVIAFFVCWLPFHAQR----LMFSYASKEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFR 297

                ..
gi 20455271 398 KA 399
Cdd:cd14979 298 VA 299
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
82-400 4.71e-25

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 104.45  E-value: 4.71e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRK-SSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15147   1 TLFPIVYSIIFVLGLIANCYVLWVFARLYPSKKlNEIKIFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCcgrslgdsccfsakaLCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15147  81 LFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGII---------------ISVAIWVIIVASASYFLFMDSTNT 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDkllGRDRQFWLGLYHSQKVLLG-FVLPLGIIILCYLLLVRFIADRraagtkggaAVAGGRPTGASAR 319
Cdd:cd15147 146 VKIDSGNFTRCFE---GYEKDNSKPVLIIHFIIIGlFFLVFLLILVCNLVIARTLLSQ---------PVQGQRNAGVKRR 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLskvtKSVTIVVLSFFLCWLPNQALT-TWSIlikfnAVPFSQEYFLCQVY-----AFPVSVCLAHSNSCLNPVLYCLVR 393
Cdd:cd15147 214 AL----WMVCTVLAVFVICFVPHHVVQgPWTL-----AVLQQWRYWDCQFRqalndAHQITLCLMSTNCVLDPVIYCFLT 284

                ....*..
gi 20455271 394 REFRKAL 400
Cdd:cd15147 285 KKFRKHL 291
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
83-397 5.78e-25

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 103.86  E-value: 5.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd16003   2 LWSLAYGFVVAVAVFGNLIVIWIILAHKRMRTVT-NYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFSTTVKVM 242
Cdd:cd16003  81 ITSVFASIYSMTAIAVDRYMAIIDPLKPRLS-----------------ATATKVVIGSIWILAFLLAFPQCLYSKTKVMP 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 GEELCLVRFPDkllGRDRQFwlgLYHSQKVLLGFVLPLGIIILCYLLLvrfiadrraagtkgGAAVAGGRPTGASA---- 318
Cdd:cd16003 144 GRTLCFVAWPG---GPDQHF---TYHIIVIVLVYCLPLLVMGITYTIV--------------GITLWGGEIPGDTSdkyh 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 ---RRLSKVTKSVTIVVLSFFLCWLPNQA-LTTWSILIKFNAVPFSQEYFLCQVYafpvsvcLAHSNSCLNPVLYCLVRR 394
Cdd:cd16003 204 eqlRAKRKVVKMMIIVVLTFAICWLPYHIyFIVTGLYQQLNRWKYIQQVYLASFW-------LAMSSTMYNPIIYCCLNK 276

                ...
gi 20455271 395 EFR 397
Cdd:cd16003 277 RFR 279
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
87-400 6.44e-25

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 104.22  E-value: 6.44e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  87 VYWVVCALGLAGNLLVLYL-MKSMQGWrkSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMN 165
Cdd:cd15377   6 VYILVFITGFLGNSVAIWMfVFHMKPW--SGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYHSVASALKshrtrghgrgdccgrSLGDSCCFSAKALCVWIWALAALASLPSAIFS-TTVKVMGE 244
Cdd:cd15377  84 LYGSILFLTCISVHRYTGVVHPLK---------------SLGRLKKKNAICISVLVWLIVVVAISPILFYSgTGVRKNKT 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 245 ELCLVRFPDKLLgrdRQFWlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavaggrPTGASARRlsKV 324
Cdd:cd15377 149 ITCYDTTSDEYL---RSYF--IYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTE---------ENNAPLRR--KS 212
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 325 TKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYA-FPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15377 213 IYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPAMCAFNDRVYAtYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
87-396 6.56e-25

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 103.62  E-value: 6.56e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  87 VYWVVCALGLAGNLLVLYLMksMQGWRK-SSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMN 165
Cdd:cd15967   6 VYILVFVVGLVGNVWGLKSL--LANWKKlGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFNLN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYHSVAsalksHRTRGHGRgdccgrslgdSCCFSAKALCVWIWALAALASLPSAIFSTTVKvmGEE 245
Cdd:cd15967  84 LYGSIGFLTCISVYRYLAIV-----HPMRVMGR----------ITTTHSVVISALVWLLVVIQSLPDLFFSKTNS--NGT 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 246 LCLVRFPDKLLGRDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVrFIADRRAAGTKGgaavaggrptgasarRLSKVT 325
Cdd:cd15967 147 KCFDTTFNDYLESYLTYSLGW-----TVTGFVIPLLIILGCYGHVV-VVLCRNNNVDKG---------------LKQRCL 205
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20455271 326 KSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVY-AFPVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15967 206 KLVIILIVLFSVCYIPYHVFRNLNLLSRILQKQGSCTQWFRGIYiAHQVSRGLVCLNSALNPLVYLMGSEDI 277
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
82-400 8.77e-25

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 103.66  E-value: 8.77e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVL---YLMKSMqgwrKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIV 158
Cdd:cd14977   1 YVIMSLSLVIFAVGIIGNLMVLcivCTNYYM----RSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASalkSHRTRGHGRgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFSTT 238
Cdd:cd14977  77 PFIQVTSLGVTVFSLCALSIDRYRAAVN---SMPMQTIGA------------CLSTCVKLAVIWVGSVLLAVPEAVLSTV 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKV----MGEELCLVRFP----DKLLGRDRQFWL-GLYhsqkvllgFVLPLGIIILCYLLLVRfiadrraagTKGGAAVA 309
Cdd:cd14977 142 AREssldNSSLTVCIMKPstpfAETYPKARSWWLfGCY--------FCLPLAFTAVCYLLMAR---------TLIRAAKE 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 310 GGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTtwsILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLY 389
Cdd:cd14977 205 YTRGTKKHMKQRRQLAKTVLCLVLVFAFCWLPEHISN---ILRATLYNEVLIDTRSTLDILDLIGQFLSFFNSCVNPIAL 281
                       330
                ....*....|.
gi 20455271 390 CLVRREFRKAL 400
Cdd:cd14977 282 YLLSEPFRRAF 292
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
87-400 1.88e-24

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 102.60  E-value: 1.88e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  87 VYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLTLPFWaVENALDFKWPFGKAMCKIVSMVTSMNM 166
Cdd:cd15185   6 LYSLVFIVGLLGNVVVVVILIKYRRLRIMT-NIYLLNLAISDLLFLFTLPFW-IHYVRWNNWVFGHGMCKLLSGFYYLGL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 167 YASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdSCCFsAKALCVWIWALAALASLPSAIFSTTVKVMGEEL 246
Cdd:cd15185  84 YSEIFFIILLTIDRYLAIVHAVFALRAR--------------TVTF-GIITSIITWGLAVLAALPEFIFYETQELFEEFL 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 CLVRFPDKllgrDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADrraagtkggaavaggrptgASARRLSKVTK 326
Cdd:cd15185 149 CSPLYPED----TEDSWKRFHALRMNIFGLALPLLIMVICYTGIIKTLLR-------------------CPSKKKYKAIR 205
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 327 SVTIVVLSFFLCWLPnqalttWSILIKFNAVPFSQEYFLCQV-----YAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15185 206 LIFVIMVVFFIFWTP------YNLVLLLSAFQSIFFETDCERskhldLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
90-391 1.61e-23

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 99.88  E-value: 1.61e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYAS 169
Cdd:cd15118   9 IVSTLGIVENLLILWVVGFRL--RRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNMFVS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 170 VFFLTAMSVTRYHSVASAL--KSHRTRGhgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIF-STTVKVMGEEL 246
Cdd:cd15118  87 GFLLAAISLDRCLLVVKPVwaQNHRNVA-----------------AAKKICGVIWAMALINTIPYFVFrDVIERKDGRKL 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 CLVRFPDKLLGRDR-----QFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgasARRL 321
Cdd:cd15118 150 CYYNFALFSPSPDNnhpicKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRC-------------------RRRP 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQALttwsILIKFNAvPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCL 391
Cdd:cd15118 211 GRFVRLVVSVVVSFALCWAPYHIF----SIIEVMA-HNQHSLRPLVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
84-400 1.69e-23

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 99.76  E-value: 1.69e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVL--YLMKsMQGWRKSSINLFvtNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15375   3 LPVMYSIIFIVGFPGNIIAIfvYLFK-MRPWKSSTIIML--NLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdSCCFSAkalCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15375  80 FHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKR------------RWAIVA---CAVVWVISLAEVSPMTFLITTKEK 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLLGRDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaAVAGGRPTGASARrl 321
Cdd:cd15375 145 NNRTICLDFTSSDNLNTIWWYNWIL-----TVLGFLLPLVIVTLCYTRIIY--------------TLAKGPHTGSASK-- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYflcQVYA-FPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15375 204 QKARRLIILILLVFYVCFLPFHILRVVRIETRLPPVSCCLKH---QVHAiYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
83-400 1.71e-23

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 100.00  E-value: 1.71e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLTLPFWAVENaLDFKWPFGKAMCKIVSMVT 162
Cdd:cd15155   2 LYGAVYSVVFILGLITNCASLFVFCFRMKMR-NETAIFMTNLAVSDLLFVFTLPFKIFYN-FNRHWPFGDSLCKISGTAF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSH--RTRGhgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15155  80 LTNIYGSMLFLTCISVDRFLAIVYPFRSRtiRTRR-----------------NSAIVCAGVWILVLSGGISASLFSTTNV 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFpdkllgrDRQFWlGLYHSQKVL----LGFVLPLGIIILCYLLLVRFIadRRAAGTKGGaavaggrptGA 316
Cdd:cd15155 143 SNTSTTCFEGF-------SKSIW-KTYLSKITIfievVGFIIPLLLNLTCSSLVLRTL--RKPATLSQI---------GT 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 SARrlsKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVP-FSQEYFLCQVYafPVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15155 204 NKE---KVLKMILVHVAIFVVCFVPYNSILFLYALVRSQAIAnCGVERFARTMY--PITLCLATLNCCFDPFVYYFTSES 278

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd15155 279 FQKSF 283
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
82-400 1.92e-23

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 99.40  E-value: 1.92e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMkSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15161   1 ILFALFYILVFILAFPGNTLALWLF-IHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgRSLgdsccfSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15161  80 FYLNMYASLYFLACISVDRFLAIVHPVKSMKIR---------KPL------YAHVVCGFLWVIVTVAMAPLLVSPQTVEV 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKllgrdrqfwlglyHSQKVL----LGFVLPLGIIILCYLLLVRfiadRRAAGTKGGAAVAggrptgas 317
Cdd:cd15161 145 NNTTVCLQLYREK-------------ASRGALvslaVAFTIPFVTTVTCYLLIIR----SLRTGKREEKPLK-------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 arrlSKVTKSVTIVVLSFFLCWLPNQALTTWSILiKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15161 200 ----DKAIKMIILVLTIFLICFVPYHISRYIYIL-SHNGAGASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFR 274

                ...
gi 20455271 398 KAL 400
Cdd:cd15161 275 ETL 277
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
82-391 2.40e-23

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 99.45  E-value: 2.40e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM-KSMQGWRKSSInlFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd16001   1 ILLPVTYSVVFVLGLPLNGTVLWLSwCRTKRWTCSTI--YLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKS--HRTRGhgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTT 238
Cdd:cd16001  79 LFYTNLYGSILFLTCISVHRFLGVCYPIRSlaYRTRR-----------------LAVIGSAATWILVVLQLLPTLVYART 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEELCL-VRFPDKLlgrDRQFwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAggrptgas 317
Cdd:cd16001 142 GSINNRTVCYdLTSPDNF---GNYF---PYGMVLTVTGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKAARA-------- 207
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20455271 318 arrlsKVTKSVTIVVLSFFLCWLPNQALTTWSILIKfnaVPFSQEYFLCQ--VYAFPVSVCLAHSNSCLNPVLYCL 391
Cdd:cd16001 208 -----KSIRTILLVCGLFALCFVPFHITRTIYLFVR---VYLVQDCPLLQfvSLAYKIWRPLVSFNSCINPLLYFL 275
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
93-400 6.70e-23

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 97.94  E-value: 6.70e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  93 ALGLAGNLLVLY-LMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFWAVENAlDFKWPFGKAMCKIVSMVTSMNMYASVF 171
Cdd:cd14975  12 AIGLPGNSFVIWsILIKVK--QRSVTMLLVLNLALADLAVLLTLPVWIYFLA-TGTWDFGLAACKGCVYVCAVSMYASVF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 172 FLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccFSAKALCVwIWALAALASLPSAIFSTTVKVMGEELCLVRF 251
Cdd:cd14975  89 LITLMSLERFLAVSRPFVSQGWRAKA--------------LAHKVLAI-IWLLAVLLATPVIAFRHVEETVENGMCKYRH 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 252 PDKLlgrdrqfWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgasARRLSKVTKSVTIV 331
Cdd:cd14975 154 YSDG-------QLVFHLLLETVVGFAVPFTAVVLCYSCLLRRLRRRR-------------------FRRRRRTGRLIASV 207
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20455271 332 VLSFFLCWLPNQA---LTTWSILIKFNAVPFSQEYFLCQvyAFPVSVCLAHSNSCLNPVLY-CLVRREFRKAL 400
Cdd:cd14975 208 VVAFAACWLPYHVgnlLEVVSELIGGSKMAGTLGKVAEA--GRPIAGALAFLSSSINPLLYaFAARGLFRSAG 278
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
82-400 2.10e-22

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 96.74  E-value: 2.10e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINlFVTNLALTDFQFVLTLPFWAVENALDfkWPFGKAMCKIVSMV 161
Cdd:cd15181   1 VFIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTEN-YLLHLALADLLLLLTFPFSVVESIAG--WVFGTFLCKLVGAI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgRSLgdsccfSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15181  78 HKLNFYCSSLLLACISVDRYLAIVHAIHSYRHR---------RLR------SVHLTCGSIWLVCFLLSLPNLVFLEVETS 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLLGRDRQFWLG--LYHsqkvLLGFVLPLGIIILCYLLLVRFIADrraagtkggaavAGGRPTGASAR 319
Cdd:cd15181 143 TNANRTSCSFHQYGIHESNWWLTSrfLYH----VVGFFLPLLIMGYCYATIVVTLCQ------------SSRRLQKQKAI 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSkvtksvTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15181 207 RVA------ILVTLVFCLCWLPYNIVIFLDTLDDLKAVVKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRND 280

                .
gi 20455271 400 L 400
Cdd:cd15181 281 L 281
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-399 3.39e-22

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 96.69  E-value: 3.39e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILIsVVYWVVCALGLAGNLLVLYLMksmqgWRKSSI----NLFVTNLALTDFQFVLT-LPFWAVENALDfKWPFGKAMCK 156
Cdd:cd15208   2 VLI-ALYILVFIVGLVGNVLVCFAV-----WRNHHMrtvtNYFIVNLSLADFLVIIIcLPATLLVDVTE-TWFFGQVLCK 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 157 IVSMVTSMNMYASVFFLTAMSVTRYHSVASAL--KSHRTRghgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAI 234
Cdd:cd15208  75 IIPYLQTVSVSVSVLTLSCIALDRWYAICHPLmfKSTAKR-------------------ARVSILIIWIVSLLIMIPQAI 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 235 FSTTVKVMGeelclVRFPDKLLGRDRQFWLG-----LYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVA 309
Cdd:cd15208 136 VMECSRVVP-----LANKTILLTVCDERWSDsiyqkVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRK 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 310 GGRPTGAS---------ARRlsKVTKSVTIVVLSFFLCWLPNQALttwSILIKFNAVPFSQEYFlcqVYA-FPVSVCLAH 379
Cdd:cd15208 211 WNKPRKSAvaaeekqlrSRR--KTAKMLIVVVIMFAICYLPVHLL---NILRYVFGLFTVDRET---IYAwFLFSHWLVY 282
                       330       340
                ....*....|....*....|
gi 20455271 380 SNSCLNPVLYCLVRREFRKA 399
Cdd:cd15208 283 ANSAINPIIYNFMSGKFREE 302
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
83-397 5.43e-22

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 95.20  E-value: 5.43e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSInlFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15372   2 LVPSLYTLVFLVGLPANGLALWVLATQVKRLPSTI--FLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCcgrslgdsccfsakaLCVWIWALAALASLPSAIFSTTVKVm 242
Cdd:cd15372  80 YGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALC---------------MCTAIWLIAAALTLPLTLQRQSYPL- 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 gEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggrptgASARRLS 322
Cdd:cd15372 144 -ERLNITLCHDVLPLDEQDTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTLL--------------------RSGQRYG 202
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455271 323 KVTKSVTIVVLSFFLCWLPNQALttwsILIKFNAVPFSQEYFLCQVYAfpVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15372 203 HAMKLTVLVLVSFVLCFTPSNLL----LLLHYSDPTLDDGGNLYIVYM--VSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
82-400 5.65e-22

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 95.85  E-value: 5.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLT--LPFWAVeNALDFKWPFGKAMCKIVS 159
Cdd:cd15337   1 YLIGIYIAIVGILGVIGNLLVIYLFSKTKSLRTPS-NMFIINLAISDFGFSAVngFPLKTI-SSFNKKWIWGKVACELYG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPsAIFSTTV 239
Cdd:cd15337  79 FAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKR---------------AFIMIIIIWLWSLLWSIP-PFFGWGR 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFpdKLLGRD---RQFWLGLYhsqkvLLGFVLPLGIIILCYLLLVRFIADRRAAGTKgGAAVAGGRPTGA 316
Cdd:cd15337 143 YVPEGFQTSCTF--DYLSRDlnnRLFILGLF-----IFGFLCPLLIIIFCYVNIIRAVRNHEKEMTQ-TAKSGMGKDTEK 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 SARRLS---KVTKSVTIVVLSFFLCWLPNQALTTWSIlikfnavpFSQEYFLCQvYAFPVSVCLAHSNSCLNPVLYCLVR 393
Cdd:cd15337 215 NDARKKaeiRIAKVAIILISLFLLSWTPYAVVALLGQ--------FGPAYWITP-YVSELPVMFAKASAIYNPIIYALSH 285

                ....*..
gi 20455271 394 REFRKAL 400
Cdd:cd15337 286 PKFRAAL 292
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
82-399 7.71e-22

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 95.45  E-value: 7.71e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKIVSM 160
Cdd:cd15048   1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVS-NFFLLNLAVADFLVgLVSMPFYIPYTLTG-KWPFGKVFCKAWLV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFS---T 237
Cdd:cd15048  79 VDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRR---------------TVLLMALVWILAFLLYGPAIIGWdlwT 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRFPDKLlgrdrQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRFIADR---------RAAGTKGGAAV 308
Cdd:cd15048 144 GYSIVPTGDCEVEFFDHF-----YFTFIT-----SVLEFFIPFISVSFFNLLIYLNIRKRsrrrplrsvPILPASQNPSR 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 309 AGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFsqeyflcqvYAFPVSVCLAHSNSCLNPVL 388
Cdd:cd15048 214 ARSQREQVKLRRDRKAAKSLAILVLVFLICWAPYTILTIIRSFCSGSCVDS---------YLYEFTFWLLWTNSAINPFL 284
                       330
                ....*....|.
gi 20455271 389 YCLVRREFRKA 399
Cdd:cd15048 285 YAACHPRFRKA 295
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
84-416 2.58e-21

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 95.85  E-value: 2.58e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271   84 ISVVYWVVCALGLAGNLLVLYLMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFwAVENALDfKWPFGKAMCKIVSMVTS 163
Cdd:PHA02638 101 IKIFYIIIFILGLFGNAAIIMILFCKK--IKTITDIYIFNLAISDLIFVIDFPF-IIYNEFD-QWIFGDFMCKVISASYY 176
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  164 MNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGdccgrslgdsccfsaKALCVWIWALAALASLPSA-IFSTTVKVM 242
Cdd:PHA02638 177 IGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIG---------------IILCIISWILSLIITSPAYfIFEASNIIF 241
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  243 GEE---------LCLVRFPDK-----LLGRDRQFWLGlyhsqkvLLGFVLPLGIIILCYLLLVRFIADRRAagtkggaav 308
Cdd:PHA02638 242 SAQdsnetisnyQCTLIEDNEknnisFLGRILQFEIN-------ILGMFIPIIIFAFCYIKIILKLKQLKK--------- 305
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  309 aggrptgasarrlSKVTKS---VTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQV----YAFPVSVCLAHSN 381
Cdd:PHA02638 306 -------------SKKTKSiiiVSIIIICSLICWIPLNIVILFATMYSFKGFNSIISEHICGFiklgYAMMLAEAISLTH 372
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 20455271  382 SCLNPVLYCLVRREFRKALKSLLWRIASPSITSMR 416
Cdd:PHA02638 373 CCINPLIYTLIGENFRMHLLMIFRNIFTNAKFSFR 407
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
83-400 3.80e-21

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 93.27  E-value: 3.80e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLM---KSMQgwrkSSINLFVTNLALTDFQFVLTLPFWAVENALDFK-WPFGKAMCKIV 158
Cdd:cd15394   2 LIIPLYSLVVLVGVVGNYLLIYVIcrtKKMH----NVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRgWVFGRFMCYFV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdsccfsakALCVW----IWALAALASLPSAI 234
Cdd:cd15394  78 FLMQPVTVYVSVFTLTAIAVDRYYVTVYPLRRRISR---------------------RTCAYivaaIWLLSCGLALPAAA 136
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 235 FSTTVKVMGEELCLVrfpdkllgrdRQFWLG------LYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGtkggaAV 308
Cdd:cd15394 137 HTYYVEFKGLDFSIC----------EEFWFGqekqrlAYACSTLLITYVLPLLAISLSYLRISVKLRNRVVPG-----SM 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 309 AGGRPTGASARRlSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYF-LCQVyafpvsVC--LAHSNSCLN 385
Cdd:cd15394 202 TQSQAEWDRARR-RKTFRLLVVVVVAFAICWLP---LHIFNVIRDIDIDLIDKQYFnLIQL------LChwLAMSSACYN 271
                       330
                ....*....|....*
gi 20455271 386 PVLYCLVRREFRKAL 400
Cdd:cd15394 272 PFLYAWLHDSFRGEL 286
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
83-392 6.67e-21

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 92.17  E-value: 6.67e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSInlFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15371   2 LIPAVYIIVVVLGVPSNAIILWMLFFRLRSVCTAI--FYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKShrtrghgrgdccgRSLGDSCcfSAKALCVWIWALAALASLPSAIFSTTVKVm 242
Cdd:cd15371  80 YGNMYCSILLLTCISINRYLAIVHPFIY-------------RSLPKKT--YAVLICALVWTIVFLYMLPFFILKQTYYL- 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 gEELCLVRFPDKLLGRDRQFWLGLYH-SQKVLLGFVLPLGIIILCYLLLVRFIadrraagtkggaavaggrpTGASARRL 321
Cdd:cd15371 144 -KELNITTCHDVLPECEQNSNFQFYYfISMAVFGFLIPLVITIFCYISIIRTL-------------------NAYEHKWF 203
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455271 322 SKVTKSVTIVVLsFFLCWLPNQAlttwsILIKFNavpFSQEYF----LCQVYAfpVSVCLAHSNSCLNPVLYCLV 392
Cdd:cd15371 204 WYVKITALVLII-FTICFAPSNV-----ILIIHH---FNYYYFnndnLYSIYL--IALCLGSLNSCLDPFLYFLM 267
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
82-400 7.25e-21

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 92.14  E-value: 7.25e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSInLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15368   1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSI-IFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTT--V 239
Cdd:cd15368  80 FYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKR---------------YAVAACIGMWLLVLTALSPLERTDLTyyV 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFPDKLLgRDRQFWLGLYHSQKVLLgFVLPLGIIILCYLLLVRFIadrraagtkggaaVAGGRPTGASAR 319
Cdd:cd15368 145 KELNITTCFDVLKWTML-PNIAAWAAFLFTLFILL-FLIPFIITVYCYVLIILKL-------------VQTSERYGREQK 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSkvTKSVTIVVLSFFLCWLPNqalttwSILIKFNAVpfSQEYFLCQVY-AFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15368 210 RRA--IYLALIVLLVFITCFAPN------NFILLAHMV--SRLFYGKSLYhAYKLTLSLSCLNSCLDPFIYYFASKEFRK 279

                ..
gi 20455271 399 AL 400
Cdd:cd15368 280 KL 281
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-398 8.74e-21

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 92.34  E-value: 8.74e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVY---WVVCALGLAGNLLVLYLMKSMQgwrkSSINLFVTNLALTDFQF-VLTLPFwavenALDF------KWPFG 151
Cdd:cd15204   1 IVLGVVYvliMLVCGVGNLLLIAVLARYKKLR----TLTNLLIANLALSDFLVaVFCLPF-----EMDYyvvrqrSWTHG 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 152 KAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdsccFSAKALCVWIWALAALASLP 231
Cdd:cd15204  72 DVLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKR-----------------RTACVVIALVWVVSLLLAIP 134
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 232 SAIFSTTVKVMGEE--LCLVRFPDKLLGRDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVA 309
Cdd:cd15204 135 SAVYSKTTPYANQGkiFCGQIWPVDQQAYYKAYYLFL-----FVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTEQIRR 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 310 ggrptgASARRLSKVTKSVTIVVLsFFLCWLPNQaltTWSILIKFNAVPFSQEYFlcQVYAFPVSVCLAHSNSCLNPVLY 389
Cdd:cd15204 210 ------RLRRRRRKVRLLVVILTA-FVLCWAPYY---GYAIVRDFFPTLLSKEKL--NTTIFYIVEALAMSNSMINTVVY 277

                ....*....
gi 20455271 390 CLVRREFRK 398
Cdd:cd15204 278 VAFNNNIRK 286
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
83-399 1.35e-20

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 91.30  E-value: 1.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLylMKSMQGWRKSSI-NLFVTNLALTDF-QFVLTLPFWAVENALDfKWPFGKAMCKIVSM 160
Cdd:cd15206   2 LIIPLYSVIFLLAVVGNILVI--VTLVQNKRMRTVtNVFLLNLAVSDLlLAVFCMPFTLVGQLLR-NFIFGEVMCKLIPY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHR--TRGHgrgdccgrslgdsccfSAKALCVwIWALAALASLPSAIFSTT 238
Cdd:cd15206  79 FQAVSVSVSTFTLVAISLERYFAICHPLKSRVwqTLSH----------------AYKVIAG-IWLLSFLIMSPILVFSNL 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEELCLVR--FPDKLLgrdRQFWlglyHSQKVLLGFVLPLGIIILCYLLLVRFI--ADRRaagtkggaavaggrpt 314
Cdd:cd15206 142 IPMSRPGGHKCRevWPNEIA---EQAW----YVFLDLMLLVIPGLVMSVAYGLISWTLleAKKR---------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 315 gasarrlskVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAvpfsqeyflcQVYAFPVSV----CLAHSNSCLNPVLYC 390
Cdd:cd15206 199 ---------VIRMLFVIVVEFFICWTPLYVINTWKAFDPPSA----------ARYVSSTTIsliqLLAYISSCVNPITYC 259

                ....*....
gi 20455271 391 LVRREFRKA 399
Cdd:cd15206 260 FMNKRFRQA 268
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
94-400 1.50e-20

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 91.63  E-value: 1.50e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  94 LGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFF 172
Cdd:cd15083  13 IGVVGNGLVIYAFCRFKSLRTPA-NYLIINLAISDFLMcILNCPL-MVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 173 LTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPsAIFSTTVKVMGEELCLVRFp 252
Cdd:cd15083  91 LAAIAVDRYLVITRPMKASVRISHRR---------------ALIVIAVVWLYSLLWVLP-PLFGWSRYVLEGLLTSCSF- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 253 dKLLGRD---RQFWLGLYhsqkvLLGFVLPLGIIILCYLLLVRFI-ADRRAAGTKGGAAVAGGRPTG-ASARRLSKVTKS 327
Cdd:cd15083 154 -DYLSRDdanRSYVICLL-----IFGFVLPLLIIIYCYSFIFRAVrRHEKAMKEMAKRFSKSELSSPkARRQAEVKTAKI 227
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20455271 328 VTIVVLSFFLCWLPNQALTTWSILIKFNAVPfsqeyflcqVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15083 228 ALLLVLLFCLAWTPYAVVALIGQFGYLEVLT---------PLATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
83-400 1.73e-20

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 91.39  E-value: 1.73e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFwAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15153   2 LYATTYIIIFIPGLLANSAALWVLCRFIS-KKNKAIIFMINLAVADLAHVLSLPL-RIHYYIQHTWPFGRFLCLLCFYLK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKShrTRGHGRGDCCgrslgdsccfsakaLCVWIWALAALASLPSAIFSTTVKVM 242
Cdd:cd15153  80 YLNMYASICFLTCISIQRCFFLLHPFKA--RDWKRRYDVG--------------ISAAVWIVVGLACLPFPLLRSKSLSN 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 GEELCLVRFPDKLLgrDRQFWLGLYHSQKvLLGFVLPLGIIILCYLLlvrfiadrraagTKGGAAVAGGRPTGASARRls 322
Cdd:cd15153 144 NNRSCFADLGMKKL--NFGAAIAMMTVAE-LFGFVIPLFIIAWCTWK------------TENSLRQRNKQQQSTSEKQ-- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 323 KVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFsqeyflCQVYAF-----PVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15153 207 KALRMVRMCAAVFFICFAPYHINFLFYLMVSESIITN------CEVSQVilqfhPISLCLASLNCCLDPILYYFMTSEFQ 280

                ...
gi 20455271 398 KAL 400
Cdd:cd15153 281 DQL 283
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
112-399 2.81e-20

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 90.54  E-value: 2.81e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 112 WRKSSINLFvtNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVAsalksH 191
Cdd:cd15922  32 WSSGTILQF--NLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVV-----H 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 192 RTRghgrgdccgRSLGDSCCFsAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRFPDKLLGrdrqfwLGLYHSQK 271
Cdd:cd15922 105 YNW---------KSLWKKKSF-MKKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIHQSELSL------LYFVWNFV 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 272 VL-LGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAavaggrptgASARRLSKVTKSVTIvvlsFFLCWLPNQALTTWSI 350
Cdd:cd15922 169 LLiLGFLLPFGVSLTCYALLGASIAKMNSNNARGRA---------MKAKSLQMIGISLVI----FIICFVPLHVTRTVGV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 20455271 351 LIKfNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15922 236 VVK-LFYPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKS 283
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
82-398 3.66e-20

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 90.22  E-value: 3.66e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLmKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15364   1 IFLVVVYSVVFALGFPANCLTLWL-TLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKShRTRGHGRgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTvKV 241
Cdd:cd15364  80 FFCNIYISILLLCCISIDRFVAVVYALES-RGRRRQR--------------IAAFISFLIFIVVGLVHSPVFIMREG-QT 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLLgrdrqfwLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRraagtkggaavaggrpTGASARRL 321
Cdd:cd15364 144 EGSHTCFETLQMDTQ-------VAGFYYARFCIGFAIPLAILIFTNYRIFRSIQTS----------------TSLTPHQK 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPnqalttWSILIKFNAVPFSQE-----YFLCQVY-AFPVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15364 201 AKVKYLAIAVIVIFLICFAP------YHLVLLVRAIAFSLYpngmcGFEERIYtPSVIFLCLSTVNSVADPIIYVLVSEN 274

                ...
gi 20455271 396 FRK 398
Cdd:cd15364 275 VRQ 277
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
83-397 7.07e-20

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 89.52  E-value: 7.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDfqfVLTLPFWAVEN---ALDFKWPFGKAMCKIVS 159
Cdd:cd16004   2 LWAIAYSLIVLVAVTGNATVIWIILAHRRMRTVT-NYFIVNLALAD---LSMAAFNTAFNfvyASHNDWYFGLEFCRFQN 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTV 239
Cdd:cd16004  78 FFPITAMFVSIYSMTAIAADRYMAIIHPFKPRLSAG-----------------STKVVIAGIWLVALALAFPQCFYSTVT 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFPDKLLGRDRQfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRfiadrraagTKGGAAVAGGRPTGASAR 319
Cdd:cd16004 141 MDQGRTKCIVAWPGDSGGKHQL----TYHLAVIVLIYLLPLAVMFVTYSIIGI---------TLWRSAVPGHQAHGAYHR 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLS---KVTKSVTIVVLSFFLCWLPNQaltTWSILIKFNAVPFSQEYfLCQVYAfpVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd16004 208 QLQakkKFVKTMVVVVVTFAICWLPYH---LYFILGSFNEDIYCQKY-IQQVYL--AIFWLAMSSTMYNPIIYCCLNQRF 281

                .
gi 20455271 397 R 397
Cdd:cd16004 282 R 282
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
83-389 7.66e-20

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 89.53  E-value: 7.66e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINlFVTNLALTDFQFVLTLPF----WAVENaldfkWPFGKAMCKIV 158
Cdd:cd15156   2 LYGCVFSMVFVLGLIANCVAIYIFMCTLKVRNETTT-YMINLAISDLLFVFTLPFrifyFVQRN-----WPFGDLLCKIS 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIF--S 236
Cdd:cd15156  76 VTLFYTNMYGSILFLTCISVDRFLAIVYPFRSKTLRTKR---------------NAKIVCAAVWLTVLAGSLPASFFqsT 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 237 TTVKVMGEELCLVRFPDKLlgrdrqfWlGLYHSQKVL----LGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggR 312
Cdd:cd15156 141 NNQLNNNSETCFENFSSKT-------W-KTYLSKIVIfieiVGFFIPLILNVTCSTMVLKTLR----------------R 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 313 PTGASARRLS--KVTKSVTIVVLSFFLCWLPnqalttWSILIKFNAVPFSQEYFLCQVYA-----FPVSVCLAHSNSCLN 385
Cdd:cd15156 197 PNTLSRSKLNkkKVLKMIFVHLFIFCFCFIP------YNVNLVLYSLVRTQTFKNCSVVAavrtmYPITLCIAVSNCCFD 270

                ....
gi 20455271 386 PVLY 389
Cdd:cd15156 271 PIVY 274
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
93-389 9.60e-20

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 89.11  E-value: 9.60e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  93 ALGLAGNLLVLY-LMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFWavenaLDF----KWPFGKAMCKIVSMVTSMNMY 167
Cdd:cd15121  12 ILGFPGNLFVVWsVLCRMK--KRSVTCILVLNLALADAAVLLTAPFF-----LHFlsggGWEFGSVVCKLCHYVCGVSMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 168 ASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTTVKVMGE-EL 246
Cdd:cd15121  85 ASIFLITLMSMDRCLAVAKPFLSQKMRTK---------------RSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINmKL 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 CLVRFPDkllgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgasARRLSKVTK 326
Cdd:cd15121 150 CIPYHPS-------VGHEAFQYLFETITGFLLPFTAIVTCYSTIGRRLRSAR-------------------FRRKRRTNR 203
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20455271 327 SVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLY 389
Cdd:cd15121 204 LVVLIIATFALFWLPYHVVNLIQVAGALQNQAGNASVLKAAKLARPNVTALAFLSSSVNPVLY 266
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
90-389 3.92e-19

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 87.41  E-value: 3.92e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYL----MKSmqgWRKSSINLFvtNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMN 165
Cdd:cd15201   9 LEFVLGLLGNGLALWIfcfhLKS---WKSSTVYLF--NLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLAMN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYHSVASALksHRTrghgrgdccgRSLGDSCcfsAKALCVWIWALAALAS----LPSAIFSTTVKV 241
Cdd:cd15201  84 RAGSIFFLTAVAVDRYFRVVHPH--HRI----------NSISVRK---AAIIACGLWLLTIAMTvyllTKKHLFPRGNAT 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLLGrdrqfwlglYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAagtkggaavaggrptgASARRL 321
Cdd:cd15201 149 QCESFNICTGTDSSSN---------WHEAMFLLEFFLPLAIILYCSVRIIWQLRGRQL----------------DRHAKI 203
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNqALTTWSILIKfnaVPFSQEyfLCQVY-----AFPVSVCLAHSNSCLNPVLY 389
Cdd:cd15201 204 KRAVQFIMVVAIVFIICFLPS-NVTRIAIWIL---KHTSNE--DCQYYrsvdlAFYITISFTYFNSMLDPVVY 270
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
92-400 5.73e-19

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 86.73  E-value: 5.73e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  92 CALGLAGNLLVLY-LMKSMQGWRKSSINLFvtNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASV 170
Cdd:cd14991  11 FVLGLPGNVVALWiFCFHSRTWKANTVYLF--NLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNRSASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 171 FFLTAMSVTRYHSVasaLKSHRTRGHGRgdcCGRSLGDSCCfsakalcvwIWALAALASLPSAIFSTTVKVMGEELCLvr 250
Cdd:cd14991  89 AFLTAVALDRYFKV---VHPHHRVNRMS---VKAAAGVAGL---------LWALVLLLTLPLLLSTLLTVNSNKSSCH-- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 251 fpDKLLGRDRQFWLGLYHSQKvLLGFVLPLGIIILCyllLVRFIADRRAAGTKGGaavaggrptgasARRLSKVTKSVTI 330
Cdd:cd14991 152 --SFSSYTKPSLSIRWHNALF-LLEFFLPLGLIVFC---SVRIACNLRIRQSLGK------------QARVQRAIRLVFL 213
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 331 VVLSFFLCWLPNqALTTWSILIKFNaVPFSQEYFLCQVyAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd14991 214 VVIVFVLCFLPS-IIAGLLALVFKN-LGSCRCLNSVAQ-LFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
83-398 6.43e-19

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 86.80  E-value: 6.43e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQgWRKSSINLFVTNLALTDFQF-VLTLPFWAVENaLDFKWPFGKAMCKIVSMV 161
Cdd:cd15981   2 MFILAYLFIFLLCMVGNGLVCFIVLKNR-QMRTVTNMFILNLAVSDLLVgIFCMPTTLVDN-LITGWPFDNAMCKMSGLV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFSTTVK- 240
Cdd:cd15981  80 QGMSVSASVFTLVAIAVERFRCIVHPFRQKLT-----------------LRKAIVTIVIIWVLALIIMCPSAVTLTVTRe 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 ---VMGEEL--------CLVRFPDKLLGRdrqfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdrraagtKGGAAVA 309
Cdd:cd15981 143 ehhFMVDDYnnsyplysCWEAWPDTEMRK-------IYTTVLFSHIYLAPLTLIVIMYARIAFKLF-------KSSAPIR 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 310 GGRPTGASARRLS----KVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPfSQEYFLCQVYAFPVSVCLAHSNSCLN 385
Cdd:cd15981 209 GSQGEEEEGRRVSkrkiKVINMLIIVALFFTLSWLP---LWTLMLLTDYGHLS-EDQLNLVTVYVFPFAHWLAFFNSSVN 284
                       330
                ....*....|...
gi 20455271 386 PVLYCLVRREFRK 398
Cdd:cd15981 285 PIIYGYFNENFRR 297
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
94-400 1.22e-18

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 85.65  E-value: 1.22e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  94 LGLAGNLLVLYLMKSMQgwRKSSI-NLFVTNLALTDFQFVLTlPFWAVENaLDFKWPFGKAMCKIVSMVTSMNMYASVFF 172
Cdd:cd14989  13 IGFIGNILILVVNLSFR--EKMTIpDLYFVNLAVADLILVAD-SLIEVFN-LNEKYYDIAVLCTFMSLFLQINMYSSIFF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 173 LTAMSVTRYHSVASALKSH--RTRGHgrgdccgrslgdsccfsAKALCVWIWALAALASL-PSAIfsTTVKVMGE-ELCL 248
Cdd:cd14989  89 LTWMSFDRYIALAKVMKSSplRTMQH-----------------ARLSCGLIWMASISATLlPFTA--VQAQHTGEvHFCF 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 249 VRFPDKLlgrdrqfWLglyhsqKVLLGFVLPLGIIILCYLLLVRFIAdrRAAGTKggaavaGGRPtgasarRLSKVTKSV 328
Cdd:cd14989 150 ADVREIQ-------WL------EVTLGFIIPFSIIGLCYSLIVRVLV--RAQKHR------RLRP------RRQKALRMI 202
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20455271 329 TIVVLSFFLCWLPNQALTTWSILIKFN--AVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd14989 203 LVVVLVFFICWLPENVFISIQLLQGTQepSESYDESFRHNHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKL 276
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
96-399 1.29e-18

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 85.48  E-value: 1.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  96 LAGNLLVL---YLMKSMQgwrkSSINLFVTNLALTDFQF-VLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVF 171
Cdd:cd15053  15 VFGNVLVImsvFRERSLQ----TATNYFIVSLAVADLLVaILVMPFAVYVEVNGGKWYLGPILCDIYIAMDVMCSTASIF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 172 FLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRF 251
Cdd:cd15053  91 NLCAISIDRYIAVTQPIKYARQKNSKR---------------VLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEECRFYN 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 252 PDKLlgrdrqfwlgLYHSqkvLLGFVLPLGIIILCYLLLVRFIadrraagtkggaavaggrptgasaRRLSKVTKSVTIV 331
Cdd:cd15053 156 PDFI----------IYSS---ISSFYIPCIVMLLLYYRIFRAL------------------------RREKKATKTLAIV 198
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 332 VLSFFLCWLPnqaLTTWSILikfNAVPFSQEYFLCQVYAFPVSVC--LAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15053 199 LGVFLFCWLP---FFTLNIL---NAICPKLQNQSCHVGPALFSLTtwLGYVNSFLNPIIYTIFNIEFRKA 262
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
94-389 1.33e-18

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 85.63  E-value: 1.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  94 LGLAGNLLVLY-LMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfKWPFGKAMCKIVSMVTSMNMYASVFF 172
Cdd:cd15122  13 LGLPGNGFIIWsILWKMKARGRSVTCILILNLAVADGAVLLLTPFFITFLTRK-TWPFGQAVCKAVYYLCCLSMYASIFI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 173 LTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRFP 252
Cdd:cd15122  92 IGLMSLDRCLAVTRPYLAQSLRKKAL---------------VRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICEPC 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 253 DKLLGrdrqfwLGLYH-SQKVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggRPTGASARRLSKVTKSVTIV 331
Cdd:cd15122 157 HASRG------HAIFHyTFETLVAFVLPFGVILFSYSVILV-------------------RLKGARFRRRARVEKLIAAI 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 332 VLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLY 389
Cdd:cd15122 212 VVAFALLWVPYHVVNLLQVVANLAPGEVLEKLGGAAKAARAGATALAFFSSSVNPLLY 269
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
83-398 2.27e-18

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 85.39  E-value: 2.27e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLT-LPFWAVENALDfKWPFGKAMCKIVSMV 161
Cdd:cd15125   2 VIPSLYLLIITVGLLGNITLVKIFITNSAMR-SVPNIFISSLAAGDLLLLVTcVPVDASRYFYE-EWMFGTVGCKLIPVI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdCCGRSLGdsccfsakalcvwIWALAALASLPSAIFSTTVKV 241
Cdd:cd15125  80 QLTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLR--TCLKAIA-------------IWVVSVLLAVPEAVFSEVAHI 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEE----LCLVRFP--DKLLGRdrqfwlglYHSQKV-LLGFVLPLGIIILCYLLLVRFIAdrRAAGTKGGAAVAGGRPT 314
Cdd:cd15125 145 MPDDnttfTACIPYPqtDEMHPK--------IHSVLIfLVYFLIPLAIISIYYYHIAKTLI--KSAHNIPGEYSEHSKRQ 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 315 GASARRLSKVtksVTIVVLSFFLCWLPNQALTTWSILiKFNAVPFSQEYFLCQVYAFPVSVClahsNSCLNPVLYCLVRR 394
Cdd:cd15125 215 METRKRLAKI---VLVFVGLFAFCWFPNHVLYMYRSF-NYNEIDSSLGHMIVTLVARVLSFC----NSCVNPFALYLLSE 286

                ....
gi 20455271 395 EFRK 398
Cdd:cd15125 287 SFRR 290
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
82-400 2.33e-18

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 85.26  E-value: 2.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLV---LYLMKSMQGwrksSINLFVTNLALTD-FQFVLTLPFWAVENALDFkWPFGKAMCKI 157
Cdd:cd15391   1 PHLINLYQSTIFLSVGGNYSVivvFYDGRRSRT----DLNYYLINLAVSDlIMALFCMPFTFTQIMLGH-WVFPAPMCPI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfsaKALCVWIWALAALASlPSAIFST 237
Cdd:cd15391  76 VLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRT-----------------KCIIASIWAISFSLS-SVQLFAG 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEE-----LCLVRFPDKllgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavAGGR 312
Cdd:cd15391 138 RTQRYGQYsegrvLCGESWPGP------DTSRSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTAPGNA-----DKGR 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 313 PTgASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAV-PFSQEYFLCQVYAfpVSVCLAHSNSCLNPVLYCL 391
Cdd:cd15391 207 DD-MQIKSKRKVIKMLVFVVLMFGICWLP---LHLFNLVQDFSTVfRNMPQHTTRLIYG--ACHWIAMSNSFVNPIIYLF 280

                ....*....
gi 20455271 392 VRREFRKAL 400
Cdd:cd15391 281 MNDSFRSIL 289
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
80-400 3.32e-18

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 84.48  E-value: 3.32e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  80 VRILISVVYWVVCALGLAGNLLVLYLMKSMqgwrKSSINLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKIV 158
Cdd:cd15979   2 VRILLYSVIFLLSVFGNMLIIVVLGLNKRL----RTVTNSFLLSLALSDLMLaVFCMPFTLIPNLMG-TFIFGEVICKAV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASALKSH--RTRGHgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFS 236
Cdd:cd15979  77 AYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRvwQTRSH-----------------AYRVIAATWLLSGLIMIPYPVYS 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 237 TTVKVMGEE-----LCLVRFPDKllgRDRQFWLGLYhsqkVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavagg 311
Cdd:cd15979 140 VTVPVPVGDrprghQCRHAWPSA---QVRQAWYVLL----LLILFFIPGVVMIVAYGLISRELY---------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 rpTGASARRlsKVTKSVTIVVLSFFLCWLPNQALTTWSilikfnavPFSQEYFLCQVYAFPVSVC--LAHSNSCLNPVLY 389
Cdd:cd15979 197 --RGLLAKK--RVIRMLVVIVAMFFLCWLPIFSANTWR--------AFDPLSAHRALSGAPISFIhlLSYTSACVNPLVY 264
                       330
                ....*....|.
gi 20455271 390 CLVRREFRKAL 400
Cdd:cd15979 265 CFMNRRFRKAF 275
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
86-399 3.91e-18

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 84.04  E-value: 3.91e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMKS-MQGWRKSSInlFVTNLALTDFQFVLTLPFwaVENALDFKWPFGKAMCKIVSMVTSM 164
Cdd:cd15923   5 AIYIPTFVLGLLLNILALWVFCWrLKKWTETNI--YMTNLAVADLLLLISLPF--KMHSYRRESAGLQKLCNFVLSLYYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdscCFSAKALCVWIWALAALASLPsaIFSTTVKVMGe 244
Cdd:cd15923  81 NMYVSIFTITAISVDRYVAIRYPLRARELRS---------------PRKAAVVCAVIWVLVVTISIP--YFLLDSSNEK- 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 245 ELCLVRFPDKllgRDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRFIADRraagtkggaavaggRPTGASARRLSKV 324
Cdd:cd15923 143 TMCFQRTKQT---ESLKVFLLL-----EIFGFLLPLIIMTFCSARVIHTLQKR--------------LDDVGSRSETKQC 200
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455271 325 TKSVTIVVLSFFLCWLPNQALTTWSILIKFNavpFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15923 201 IRVIMANLIVFIVCFLPVHVGFFVKFIVGKS---YSCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFREA 272
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
86-400 4.29e-18

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 84.55  E-value: 4.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKIVSMVTSM 164
Cdd:cd15980   5 ASYLLIFLLCMMGNGVVCFIVLRSKHMRTVT-NLFILNLAISDLLVgIFCMPTTLLDNIIA-GWPFGSTVCKMSGMVQGI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSttvKVMGE 244
Cdd:cd15980  83 SVSASVFTLVAIAVDRFRCIVYPFKQKLTIS-----------------TAVVIIVIIWVLAIAIMCPSAVML---HVQEE 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 245 ELCLVRFPDKLLGRD----RQFWLG-----LYHSQKVLLGFVLPLGIIILCYLLLvrFIADRRAAGTKGGAavAGGRPTG 315
Cdd:cd15980 143 KNYRVVLGSQNKTSPvywcREDWPNqemrkIYTTVLFANIYLAPLSLIVIMYARI--GITLFKTAMPHTGK--HNQEQRH 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 ASARRLSKVTKSVTIVVLSFFLCWLPnqaltTWSILIKFNAVPFSQ-EYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRR 394
Cdd:cd15980 219 VVSRKKQKVIKMLLIVALLFILSWLP-----LWTLMMLSDYANLSPnQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFNE 293

                ....*.
gi 20455271 395 EFRKAL 400
Cdd:cd15980 294 NFRRGF 299
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
82-400 6.63e-18

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 83.90  E-value: 6.63e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLP----FWAVENAldfkWPFGKAMCKI 157
Cdd:cd15382   1 LVSIIVYSVLFLIAAVGNLTVLLILLRNRRRKRSRVNILLMHLAIADLLVTFIMMpleiGWAATVA----WLAGDFLCRL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgRSLGDSccfsakalcvwiWALAALASLP-SAIF- 235
Cdd:cd15382  77 MLFFRAFGLYLSSFVLVCISLDRYFAILKPLRLSDARRRGR-----IMLAVA------------WVISFLCSIPqSFIFh 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 -STTVKVMGEELClVRFpDKLLGRDRQFwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADR-RAAGTKGGAAVAGGRP 313
Cdd:cd15382 140 vESHPCVTWFSQC-VTF-NFFPSHDHEL---AYNIFNMITMYALPLIIIVFCYSLILCEISRKsKEKKEDVSEKSSSVRL 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 314 TGAS----ARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQ--EYFLcqvYAFPVsvclahSNSCLNPV 387
Cdd:cd15382 215 RRSSvgllERARSRTLKMTIVIVLVFIICWTPYFIMSLWYWFDRESASKVDPriQKGL---FLFAV------SNSCMNPI 285
                       330
                ....*....|...
gi 20455271 388 LYCLVRREFRKAL 400
Cdd:cd15382 286 VYGYFSIDLRREL 298
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
90-389 1.13e-17

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 83.31  E-value: 1.13e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMKSMqGWRKSSINLFVTNLALTD-----FQfVLTLPFWAVEnaldFKWPFGKAMCKIVSMVTSM 164
Cdd:cd15386   9 AILVVATAGNLAVLLAMYRM-RRKMSRMHLFVLHLALTDlvvalFQ-VLPQLIWEIT----YRFQGPDLLCRAVKYLQVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccfSAKALCVWIWALAALASLPSA-IFSTTVKVMG 243
Cdd:cd15386  83 SMFASTYMLIMMTVDRYIAVCHPLRTLQQPSR----------------QAYLMIGATWLLSCILSLPQVfIFSLREVDQG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 EEL--CLVRFpdkllgrdrQFWLGL--YHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASAR 319
Cdd:cd15386 147 SGVldCWADF---------GFPWGAkaYITWTTLSIFVLPVAILIVCYSLICYEICKNLKGKTQTSRSEGGGWRTQGMPS 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSKV----------TKSVTIVVLSFFLCWLPNQALTTWSILIKfNAVPFSQEYFlcqvyAFPVSVCLAHSNSCLNPVLY 389
Cdd:cd15386 218 RVSSVrtisrakirtVKMTFVIVLAYIACWAPFFSVQMWSVWDE-NAPDEDSSDF-----AFTITMLLASLSSCCNPWIY 291
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
83-400 1.55e-17

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 82.57  E-value: 1.55e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLTLPFWAvENALDFKWPfGKAMCKIVSMVT 162
Cdd:cd15171   2 LVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVE-NIYFLNLAVSNLCFLLTLPFWA-HAAWHGGSL-GNPTCKVLVALS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFltamsvtryhSVASALKSHRTRGHGRGDCCGRSLGdSCCFSAkalCVWIWALAALASLPSAIFSTTVKVM 242
Cdd:cd15171  79 SVGLHSEALF----------NVLLTVQASRVFFHGRLASSARRVA-PCGIIA---SVLAWLTAFLVTLPEFVFYKPQMDS 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 GEELCLVRFPDKLLGrDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLvrfiadrraagtkggaavaggRPTGASARRLS 322
Cdd:cd15171 145 QKSKCAFSRPHFLPA-EETFWKYFLTLKMNIVVLVFPLLVFIICCVQL---------------------RKTQRFRERQR 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 323 KVTKSVTIVVLSFFLCWLP-NQALttwsILIKFnavpfsQEYFLCQ----VYAFPVSV----CLAHSNSCLNPVLYCLVR 393
Cdd:cd15171 203 DLSKLVFAIMVVFLLMWAPyNIAL----FLSAF------KEHFSLRdcksSYHLDASVqvtkLIATTHCCVNPLLYALLD 272

                ....*..
gi 20455271 394 REFRKAL 400
Cdd:cd15171 273 PAFRRRL 279
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
82-400 1.72e-17

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 82.68  E-value: 1.72e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM--KSMqgwrKSSINLFVTNLALTDFQFVLT--LPFWAVENALDFKWPFGKAM--- 154
Cdd:cd14978   1 VLYGYVLPVICIFGIIGNILNLVVLtrKSM----RSSTNVYLAALAVSDILVLLSalPLFLLPYIADYSSSFLSYFYayf 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 155 CKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAI 234
Cdd:cd14978  77 LPYIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRR---------------ARRVILIIIIFSLLLNLPRFF 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 235 FSTTVKVMGEELCLVRFPD-KLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadrRAAGTKGGAAVAGGRP 313
Cdd:cd14978 142 EYEVVECENCNNNSYYYVIpTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRAL---RKSKKRRRLLRRRRRL 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 314 TGASARRLSKVTKSVTIVVLSFFLCWLPnQALTTwsILIKFNAVPFSQEYFlcqVYAFPVSVCLAHSNSCLNPVLYCLVR 393
Cdd:cd14978 219 LSRSQRRERRTTIMLIAVVIVFLICNLP-AGILN--ILEAIFGESFLSPIY---QLLGDISNLLVVLNSAVNFIIYCLFS 292

                ....*..
gi 20455271 394 REFRKAL 400
Cdd:cd14978 293 SKFRRTF 299
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
85-400 2.16e-17

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 82.08  E-value: 2.16e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  85 SVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSInLFVTNLALTDFQFVLTLPFwAVENALDFKWPFGKAMCKIVSMVTSM 164
Cdd:cd15152   4 AVTYTVILIPGLIGNVLALWVFYAYVKETKRAV-IFMINLAIADLLQVLSLPL-RIFYYLNKSWPFGKFLCMFCFYLKYV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALKSHrtrghgrgDCCGRslgdsccfSAKALCVWIWALAALASLPSAIFSTTvKVMGE 244
Cdd:cd15152  82 NMYASIYFLVCISVRRCLYLIYPFRYN--------DCKRK--------CDVYISIAGWLVVCVGCLPFPLLRQS-QDTNP 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 245 ELCLVRFPDKLLGRDRQFwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAvaggrptgasarrlSKV 324
Cdd:cd15152 145 TCCFADLPLRNVGLTTSV---IMLTIAELTGFVTPLLIVLYCSWKTVMSLREKTPVLQDLGEK--------------KKA 207
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 325 TKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVP-FSQEYFLCQVYafPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15152 208 LKMILTCAVVFLICFAPYHISFPLDFLVKSNKIKsCTARKVILIFH--PVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
79-400 2.93e-17

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 82.03  E-value: 2.93e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  79 RVRILISVVywvVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTD-FQFVLTLPFWAVENaLDFKWPFGKAMCKI 157
Cdd:cd15383   1 KVRVAVTFV---LFVLSACSNLAVLWSATRNRRRKLSHVRILILHLAAADlLVTFVVMPLDAAWN-VTVQWYAGDLACRL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsaKALCVwIWALAALASLPSAIFST 237
Cdd:cd15383  77 LMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARRRNR----------------IMLCA-AWGLSALLALPQLFLFH 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEE---LCLVRfpdkllGRDRQFWLG-LYHSQKVLLGFVLPLGIIILCYLLLVRFIADRraaGTKGGAAVAGGRP 313
Cdd:cd15383 140 TVTATPPVnftQCATH------GSFPAHWQEtLYNMFTFFCLFLLPLLIMIFCYTRILLEISRR---MKEKKDSAKNEVA 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 314 TGASARRLSKV---TKSVTIV-VLSFFLCWLPNQALTTWSilikfnavpfsqeYFLCQVYAFPVSVCLAHS-------NS 382
Cdd:cd15383 211 LRSSSDNIPKArmrTLKMTIViVSSFIVCWTPYYLLGLWY-------------WFSPEMLEQTVPESLSHIlflfgllNA 277
                       330
                ....*....|....*...
gi 20455271 383 CLNPVLYCLVRREFRKAL 400
Cdd:cd15383 278 CLDPLIYGLFTISFRRGL 295
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
76-407 5.39e-17

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 81.87  E-value: 5.39e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271   76 TEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFwAVENALDfKWPFGKAMC 155
Cdd:PHA02834  23 VNSDVNYFVIVFYILLFIFGLIGNVLVIAVLIVKR--FMFVVDVYLFNIAMSDLMLVFSFPF-IIHNDLN-EWIFGEFMC 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  156 KIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHrtrghgrgdccGRSLGDSCCFSakalcVWIWALAALASLPSAIF 235
Cdd:PHA02834  99 KLVLGVYFVGFFSNMFFVTLISIDRYILVVNATKIK-----------NKSISLSVLLS-----VAAWVCSVILSMPAMVL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  236 STTVKVMGEELCLVRfpdkllGRDRQF-WLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrpt 314
Cdd:PHA02834 163 YYVDNTDNLKQCIFN------DYHENFsWSAFFNFEINIFGIVIPLIILIYCYSKILYTLKNCK---------------- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  315 gaSARRLSKVTKSVTIVVLSFFLcWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRR 394
Cdd:PHA02834 221 --NKNKTRSIKIILTVVTFTVVF-WVPFNIVLFINSLQSVGLIDIGCYHFKKIVYSIDIAELISFVHCCVNPIIYAFVGK 297
                        330
                 ....*....|...
gi 20455271  395 EFRKALKSLLWRI 407
Cdd:PHA02834 298 NFKKVFKNMFCRT 310
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
82-398 6.48e-17

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 80.98  E-value: 6.48e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM---KSMQgwrkSSINLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKI 157
Cdd:cd15205   1 TAFVITYVLIFVLALFGNSLVIYVVtrkRAMR----TATNIFICSLALSDLLItFFCIPFTLLQNISS-NWLGGAFMCKM 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPsAIFST 237
Cdd:cd15205  76 VPFVQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRR---------------AFTMLGLVWIVSVIVGSP-MLFVQ 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRFpdkLLGRDRqfWLGLYHSQK-----VLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGR 312
Cdd:cd15205 140 QLEVKYDFLYEKRH---VCCLER--WYSPTQQKIyttfiLVILFLLPLTTMLFLYSRIGYELWIKKRVGDASVLQTIHGI 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 313 PTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTtwsILIKFNAVPFSQEYFLCQVyAFPVSVCLAHSNSCLNPVLYCLV 392
Cdd:cd15205 215 EMSKISRKKKRAVKMMVTVVLLFAVCWAPFHVVH---MMIEYSNLENKYDGVTIKL-IFAIVQLIGFSNSFNNPIVYAFM 290

                ....*.
gi 20455271 393 RREFRK 398
Cdd:cd15205 291 NENFKK 296
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
84-400 7.02e-17

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 81.00  E-value: 7.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTS 163
Cdd:cd15928   3 VTAVCSVLMLVGASGNLLTVLVIGRSRDMR-TTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 164 MNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPsaifsTTVKVMG 243
Cdd:cd15928  82 TCTYASILHITALSVERYLAICHPLRAKVLVTRGR---------------VKLLIAVIWAVAIVSAGP-----ALVLVGV 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 EELCLVRFPDKLLGRDRQFWLGLYHSQKVL--LGFVLPLGIIILCYLLLVRFIADRRAAgtkggaavagGRPTGASARRL 321
Cdd:cd15928 142 EHIQGQQTPRGFECTVVNVSSGLLSVMLWVstSFFFVPMVCLSLLYGLIGRALWDRRQR----------SRTAGASRRDN 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 S--KVTKSVTIVVLSFFLCWLPNQAlttwSILIKFNAvpFSQEYFLCQV--YAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15928 212 NhrQTVRMLAVIVLAFVLCWLPFHV----GRVIFNHS--RASTKHLHYVsqYFNLVSFVLFYLSAAINPILYNLMSKRYR 285

                ...
gi 20455271 398 KAL 400
Cdd:cd15928 286 YAV 288
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
87-389 8.20e-17

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 80.51  E-value: 8.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  87 VYWVVCALGLAGNLLVLYLM--KSMQGWRKSSInlFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSM 164
Cdd:cd15376   6 ILGVEFLVAVLGNGLALWLFvtRERRPWHTGVV--FSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALkshRTRGHGRGdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTT-VKVMG 243
Cdd:cd15376  84 NLYGSIFFITCISLNRYLGIVHPF---FTRSHVRP------------KHAKLVSLAVWLLVAALSAPVLSFSHLeVERHN 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 EELCLVRFPDKLLGRDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggRPTGASARRLSK 323
Cdd:cd15376 149 KTECLGTAVDSRLPTYLPYSLFL-----AVVGCGLPFLLTLASYLAIVWAVL----------------RSPGITTLEKRK 207
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 324 VTKSVTIVVLSFFLCWLPNQALTTWSIlikFNAVPFSQEYFLCQVY-AFPVSVCLAHSNSCLNPVLY 389
Cdd:cd15376 208 VAALVAVVVALYAVSFVPYHILRNLNL---YRRLQWLKAAASLRIYfAYQVTKGLVTLNMCIHPLLY 271
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
84-398 1.55e-16

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 79.94  E-value: 1.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTS 163
Cdd:cd15124   3 IPTVYGIIILIGLIGNITLIKIFCTVKSMRNVP-NLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 164 MNMYASVFFLTAMSVTRYHSVASALKSHRTrgHGRGDCCGRSlgdsccfsakalcVWIWALAALASLPSAIFSTtvkvmg 243
Cdd:cd15124  82 TSVGVSVFTLTALSADRYKAIVRPMDIQAS--NALMKICLKA-------------ALIWILSMLLAIPEAVFSD------ 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 eelcLVRFPDKllGRDRQFWL--------GLY---HSQKVLLGF-VLPLGIIILCYLLLVR-FIADRRAAGTKGGAAVag 310
Cdd:cd15124 141 ----LHPFYDK--STNKTFVScapyphsnELHpkiHSMASFLIFyVIPLSIISVYYYFIAKnLIRSAYNLPVEGNVHV-- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 311 gRPTGASARRLSkvtKSVTIVVLSFFLCWLPNQALTTWSILiKFNAVPFSQEYFLCQVYAfpvsVCLAHSNSCLNPVLYC 390
Cdd:cd15124 213 -RRQIESRKRLA---KTVLVFVGLFAFCWLPNHIIYLYRSY-HYSEVDTSMLHFVSSICA----RILAFTNSCVNPFALY 283

                ....*...
gi 20455271 391 LVRREFRK 398
Cdd:cd15124 284 LLSKSFRK 291
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
83-400 1.96e-16

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 79.42  E-value: 1.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSInLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15369   2 FVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAV-IYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVm 242
Cdd:cd15369  81 YCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRR---------------ASFTCAAIWLLSIAGVVPLLLSEQTIQI- 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 gEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaAVAGGRPTGASARRLS 322
Cdd:cd15369 145 -PDLGITTCHDVLNEQLLMGYYVYYFSIFSCLFFFVPLIITTVCYVSIIR--------------CLSSSSDVANSSKKTR 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 323 KVTKSVTIVVLsFFLCWLPNqalttwSILIKFNAVPFSQEYFLCQVY-AFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15369 210 ALFMAVAVFCV-FVICFGPT------NVLLLAHYVRFAYTSTNDASYfAYLLCVCVGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
82-397 4.16e-16

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 78.30  E-value: 4.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMkSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15370   1 VFLPIVYIIVFVVGLPSNAMALWVF-LFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgRSLGDSCCfsakalcvwIWALAALASLPSAIFSTTVKV 241
Cdd:cd15370  80 FYGNMYCSILFMTCLSVQRYWVIVNPMSHSRKKAN-------IAIGISLA---------IWLLILLVTIPLYLVKQTVFI 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 --MGEELCLVRFPDKLLGRDrqfwLGLYHSQKVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaAVAGGRPTGASAR 319
Cdd:cd15370 144 paLDITTCHDVLPEQLLVGD----MFNYFLSLAIGVFLFPAFLTAVAYVLMIR--------------ALKSSINDESIEK 205
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSqeyflcqVYAF-PVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15370 206 KRKRAIKLIVTVLVMYLICFTPSNLLLVVHYFLLKNQGQSS-------VYAFyITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
84-400 4.51e-16

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 78.22  E-value: 4.51e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLY-LMKSMQGWRKSSINLFvtNLALTDFQFVLTLPFWaVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15378   3 LPTMYSIEFVLGFIGNTIVILgYIFCLKNWKSSNIYLF--NLSVSDLAFLCTLPML-VYSYSNGQWLFGDFLCKSNRYLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSH---RTRghgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTV 239
Cdd:cd15378  80 HANLYSSILFLTFISIDRYLLIKYPFREHilqKKR------------------SAVAISLAIWVLVTLELLPILTFIGPN 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFPDKLLGRDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRFIADRraagtkggaavAGGRPTGASar 319
Cdd:cd15378 142 LKDNVTKCKDYASSGDATNSLIYSLFL-----TVTGFLIPLCVMCFFYYKIALFLKNR-----------NRQLANATS-- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 rLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15378 204 -FEKPLTLVILAVVIFSVLFTPYHVMRNVRIASRLDSIGVSECTLIIIKSLYIVTRPIAFLNSVINPVFYFLMGDHFREM 282

                .
gi 20455271 400 L 400
Cdd:cd15378 283 L 283
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
82-400 8.16e-16

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 77.57  E-value: 8.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSmQGWRKSSINLFVTNLALTDFQF-VLTLPFWAVENALDFkWPFGKAMCKIVSM 160
Cdd:cd15396   1 FLLIIAYSVVTIVGLFGNLCLITIIKK-QKEEHNVTNILIANLSLSDVLVcVMCIPFTAVYTLMDH-WIFGETMCKLTSF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdCCGRSLgdsccfsakalcvwIWALAALASLPSAIFSttvK 240
Cdd:cd15396  79 VQSVSVSVSIFSLVLIAIERYQLIVNPRGWKPSASHA---YWGIVL--------------IWLFSLMISIPFLIFH---Q 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPDKLLgRDR----QFWLG-----LYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavagG 311
Cdd:cd15396 139 LTDEPFRNLSSHSDFY-KDKvvciEAWPSeterlIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNSKIDR-------M 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 RPTGASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNavpfsQEYFLCQVYAFPVSVC--LAHSNSCLNPVLY 389
Cdd:cd15396 211 RENESRLSENKRINTMLISIVVTFAACWLP---LNIFNVVFDWN-----HEVLMSCHHNLVFTLChlVAMVSTCINPIFY 282
                       330
                ....*....|.
gi 20455271 390 CLVRREFRKAL 400
Cdd:cd15396 283 GFLNKNFQKDL 293
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
82-398 9.67e-16

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 77.61  E-value: 9.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLylmksMQGWRK----SSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKI 157
Cdd:cd15379   1 VLLPLVYSVVFLLGLPLNAVVI-----GQIWATrqalSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccGRSLgdsccfsAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15379  76 VRFQFYTNLHGSILFLTCISVQRYLGICHPLASWHKKK-------GKKL-------TWLVCGAVWLVVIAQCLPTFVFAS 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRFPDKLLGRDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRFIAdrRAAGTKGGAAVAGgrptgas 317
Cdd:cd15379 142 TGTQRNRTVCYDLSPPARSTAYFPYGITL-----TRTGFLLPFAARLACYCSMATILC--RVVIAVAVVAAPG------- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 aRRLSKVTKSVTIVVLSFFLCWLPNQaLTTWsiliKFNAVPFSQEYFLCQVYAFPV----SVCLAHSNSCLNPVLYCLVR 393
Cdd:cd15379 208 -EKRGKAARMIIVVAAVFLISFLPFH-YTKT----RYLQVRSWDGGPCTTRQAFAEaykrTRPFASMNSVLDPILFYFTQ 281

                ....*
gi 20455271 394 REFRK 398
Cdd:cd15379 282 SKFRP 286
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
82-400 1.35e-15

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 76.61  E-value: 1.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQ-NWFLVSLAVADILVgLLIMPF-SLVNELMGYWYFGSVWCEIWLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAI--FSTT 238
Cdd:cd15059  79 LDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRR---------------AKAMIAAVWIISAVISLPPLFgwKDEQ 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEELCLVRfpdkllgrdRQFWLGLYhsqKVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrptgASA 318
Cdd:cd15059 144 PWHGAEPQCELS---------DDPGYVLF---SSIGSFYIPLLIMIIVYARIYR-----------------------AAK 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSqeyflcqvyAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15059 189 RKERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTCGVPEL---------LFKFFFWLGYCNSALNPVIYTIFNKDFRR 259

                ..
gi 20455271 399 AL 400
Cdd:cd15059 260 AF 261
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
86-389 1.82e-15

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 76.71  E-value: 1.82e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQF-VLTLPFWAVEnALDFKWPFGKAMCKIVSMVTSM 164
Cdd:cd15384   5 VVLAVMFVISFIGNLLTIIQIYRLRR-SRRTIYSLLLHLAIADLLVtFFCIPSEAIW-AYTVAWLAGNTMCKLVKYLQVF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsakALCVWIWALAALASLPSA-IFSTTVKVMG 243
Cdd:cd15384  83 GLYLSTYITVLISLDRCVAILYPMKRNQAPERVR-----------------RMVTVAWILSPIFSIPQAvIFHVERGPFV 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 EEL--CLVRfpdkllGRDRQFWL-GLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdRRAAGTKGGAAVAggRPTGASARR 320
Cdd:cd15384 146 EDFhqCVTY------GFYTAEWQeQLYNMLSLVFMFPIPLVIMVTCYVLIFITLS-KSSRDFQGLEIYT--RNRGPNRQR 216
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20455271 321 L-----SKVTKSVTIVVLSFFLCWLPNQALTTWSILikFNAVPFSQEYFLcqvYAFPVSVclahSNSCLNPVLY 389
Cdd:cd15384 217 LfhkakVKSLRMSAVIVTAFILCWTPYYVIMIWFLF--FNPYPLNDILFD---VIFFFGM----SNSCVNPLIY 281
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
82-399 1.87e-15

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 76.70  E-value: 1.87e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTD-FQFVLTLPFWAVENALDFkWPFGKaMCKIVSM 160
Cdd:cd15057   1 IITGCILYLLVLLTLLGNALVIAAVLRFRHLRSKVTNYFIVSLAVSDlLVAILVMPWAAVNEVAGY-WPFGS-FCDVWVS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRtrghgrgdccgrslgDSCCFSAKALCVWIWALAALAS-LPSAIFSTTV 239
Cdd:cd15057  79 FDIMCSTASILNLCVISVDRYWAISSPFRYER---------------RMTRRRAFIMIAVAWTLSALISfIPVQLGWHRA 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFPdkllgRDRQFWL-GLYHSQKVLLGFVLPLGIIILCY---LLLVRFIADRRAAGTKGGAAVAGGRPTG 315
Cdd:cd15057 144 DDTSEALALYADP-----CQCDSSLnRTYAISSSLISFYIPVAIMIVTYtriYRIARRQIRRIAALERAAQESTNPDSSL 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 -ASARRLSKVTKSVTIVVLSFFLCWLPNQALttwSILIKFnAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLvRR 394
Cdd:cd15057 219 rSSLRRETKALKTLSIIMGVFVCCWLPFFIL---NCVLPF-CDLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIYAF-NA 293

                ....*
gi 20455271 395 EFRKA 399
Cdd:cd15057 294 DFRKA 298
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
83-400 1.89e-15

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 76.33  E-value: 1.89e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMR-TITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVH 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgrslgdsccFSAKAL---CVWIWALAALASLPSAIFSTTV 239
Cdd:cd15012  80 SLSYTASIGILVVISVERYIAILHPLRCKQL------------------LTAARLrvtIVTVWLTSAVYNTPYFVFSQTV 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEElCLVRFPDKLLGRDRqFWLGLYHSQKVLLGFVLPLGIIILCYLLLvrfiadrraagtkggaAVAGGRPTGASAR 319
Cdd:cd15012 142 EILVTQ-DGQEEEICVLDREM-FNSKLYDTINFIVWYLIPLLIMTVLYSKI----------------SIVLWKSSSIEAR 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RlsKVTKSVTIVVLSFFLCWLPNQALTTWSilikfnavpFSQEYFLC----QVYAFPVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15012 204 R--KVVRLLVAVVVSFALCNLPYHARKMWQ---------YWSEPYRCdsnwNALLTPLTFLVLYFNSAVNPLLYAFLSKR 272

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd15012 273 FRQSM 277
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
83-400 2.12e-15

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 76.34  E-value: 2.12e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYL-MKSMQgwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfKWPFGKAMCKIVSMV 161
Cdd:cd15154   2 LHLVGYSLLFPVGLLLNAVALWVfVRYLR--LHSVVSIYMCNLALSDLLFTLSLPLRIYYYANH-YWPFGNFLCQFSGSI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALK-SHRTRGHgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIF--STT 238
Cdd:cd15154  79 FQMNMYGSCLFLMCINVDRYLAIVHPLRfRHLRRPK----------------VARLLCLAVWALILGGSVPAAIVhsSSD 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEE--LCLVRFPDKLLGRDRQFWLglyhsQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavaggrptga 316
Cdd:cd15154 143 CLLHGEKvyRCFESFSDNDWKGLLPLVV-----LAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQG------------- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 sarRLSKVTKSVTIVVLSFFLCWLP-NQALTTWSiLIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15154 205 ---RRRKTVRLLLVNLVIFLICFVPyNTTLAVYG-LLRANLVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEG 280

                ....*
gi 20455271 396 FRKAL 400
Cdd:cd15154 281 FRNTL 285
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
82-398 3.98e-15

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 75.00  E-value: 3.98e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLY---LMKSMQgwrkSSINLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKI 157
Cdd:cd15329   1 VLIGIVLLIIILGTVVGNALVIIavcLVKKLR----TPSNYLIVSLAVSDLLVaLLVMPLAIIYELSG-YWPFGEILCDV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALK--SHRTRghgrgdccgrslgdsCCFSAKALCVWIwaLAALASLPSaIF 235
Cdd:cd15329  76 WISFDVLLCTASILNLCAISVDRYLVITRPLTyaVKRTP---------------KRMALMIAIVWL--LSALISIPP-LF 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 STTVKVMGEELCLVrfpdkllgrDRQFWlglYHSQKVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrptg 315
Cdd:cd15329 138 GWKNKVNDPGVCQV---------SQDFG---YQIYATFGAFYIPLIVMLVLYYKIYR----------------------- 182
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 aSARRLSKVTKSVTIVVLSFFLCWLPN---QALTTWSILIKFNAVPFSQEYFLcqvyafpvsVCLAHSNSCLNPVLYCLV 392
Cdd:cd15329 183 -AAKSERKAIKTLGIIMGAFTLCWLPFfilALLRPFLKPIKCSCIPLWLSRLF---------LWLGYANSFLNPIIYAKF 252

                ....*.
gi 20455271 393 RREFRK 398
Cdd:cd15329 253 NREFRT 258
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
91-399 7.39e-15

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 74.77  E-value: 7.39e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  91 VCALGLAGNLLVLYLMKSMQgWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASV 170
Cdd:cd15000   9 VVLFGIFGNFVLLYILASNR-SLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 171 FFLTAMSvtrYHSVASALKSHRTRGHGRGdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVkvmgeELCLVR 250
Cdd:cd15000  88 LALCAVS---YDRLTAIVLPSEARLTKRG--------------AKIVIVITWIVGLLLALPLAIYRSYR-----ERQWKN 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 251 FPDKLLGRDRQFwLGLYHSQKVLLGFVLPLGIIILCYLLLVrFIADRRAAgtkggAAVAGGRPTGASARRlsKVTKSVTI 330
Cdd:cd15000 146 FLETYCAENTQV-LPIYWHVIITVLVWLPLGIMLICYSAIF-WKLDKYER-----RVLRREHPSVVRYKK--KAAKTLFI 216
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 331 VVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFpVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15000 217 VLITFVVCRIPFTALIFYRYKLVPNDNTQNSVSGSFHILWF-ASKYLMFLNAAVNPLIYGFTNENFRKA 284
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
82-400 1.03e-14

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 74.23  E-value: 1.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLmkSMQGWRK-SSINLFVTNLALTDF-QFVLTLPFWAVEnALDFKWPFGKAMCKI-- 157
Cdd:cd15074   1 IIIGIYLTVIGILSTLGNGTVLFV--LYRRRSKlKPAELLTVNLAVSDLgISVFGYPLAIIS-AFAHRWLFGDIGCVFyg 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 -VSMVTSMNmyaSVFFLTAMSVTRYHSVASALKSHR-TRGHGrgdccgrslgdsccfSAKALCVWI----WALAALASLP 231
Cdd:cd15074  78 fCGFLFGCC---SINTLTAISIYRYLKICHPPYGPKlSRRHV---------------CIVIVAIWLyalfWAVAPLVGWG 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 232 S---AIFSTTvkvmgeelCLVRFPDKLLGRDRQfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFI--ADRRAAGTkgga 306
Cdd:cd15074 140 SygpEPFGTS--------CSIDWTGASASVGGM----SYIISIFIFCYLLPVLIIVFSYVKIIRKVksSRKRVAGF---- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 307 avagGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSqeyflcqvyAFPVSVCLAHSNSCLNP 386
Cdd:cd15074 204 ----DSRSKRQHKIERKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSPDSVPIL---------ASILPALFAKSSCMYNP 270
                       330
                ....*....|....
gi 20455271 387 VLYCLVRREFRKAL 400
Cdd:cd15074 271 IIYLLFSSKFRQDL 284
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
82-397 1.17e-14

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 74.13  E-value: 1.17e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTD-----FQFVLTLPFwAVENaldfKWPFGKAMCK 156
Cdd:cd16002   1 ALWAVAYSVIVVVSVVGNIIVMWIILAHKRMRTVT-NYFLVNLAFAEasmsaFNTVINFTY-AIHN----EWYYGLEYCK 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 157 IVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRtrghgrgdccgrslgdSCCFSAKALCVwIWALAALASLPSAIFS 236
Cdd:cd16002  75 FHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQPRL----------------SATATKVVICV-IWVLAFLLAFPQGYYS 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 237 TTVKVMGEELCLVRFPDKLLGRDRQfwlgLYHSQKVLLGFVLPLGIIILCYLLLvrfiadrraaGTKGGAAVAGGRPTGA 316
Cdd:cd16002 138 DTEEMPGRVVCYVEWPEHEERKYET----VYHVCVTVLIYFLPLLVIGCAYTVV----------GITLWASEIPGDSSDR 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 SARRLS---KVTKSVTIVVLSFFLCWLPNQaltTWSILIKFNAVPFSQEyFLCQVYAfpVSVCLAHSNSCLNPVLYCLVR 393
Cdd:cd16002 204 YHEQVSakrKVVKMMIVVVCTFAICWLPYH---IYFLLQYFHPELYEQK-FIQQVYL--AIMWLAMSSTMYNPIIYCCLN 277

                ....
gi 20455271 394 REFR 397
Cdd:cd16002 278 DRFR 281
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
92-390 1.28e-14

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 74.04  E-value: 1.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  92 CALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVF 171
Cdd:cd15200  11 FVLGLVGNGIALFIFCFHRRPWKSN-TMYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLSMNRTASIV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 172 FLTAMSVTRYHSVasaLKSHRTrghgrgdccgrsLGDSCCFSAKALCVWIWALAALASLPsaIFSTTVKVMGEELCLVRF 251
Cdd:cd15200  90 FLTAIALNRYLKV---VHPHHQ------------LSKASVGCAAKVAAGLWILILLLNIH--LLLLDHVQSNSTCLSYDH 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 252 PDKLLGRDRqfwlglYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGgaavaggrptgasARRLSKVtksVTIV 331
Cdd:cd15200 153 GTDPSASDR------WHRILFFLEFFLPLGIILFCIFSIILTLKQRKLAKQAG-------------PQRAVKV---LAVI 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 332 VLSFFLCWLPNQALTTWSILIKfnAVPFSQEYFLCQvYAFPVSVCLAHSNSCLNPVLYC 390
Cdd:cd15200 211 VLVYTVCFLPSILFALASLVAF--KVSQCRSLDLCT-QLFHGSLAFTYLNSALDPVLYC 266
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
82-392 1.52e-14

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 73.64  E-value: 1.52e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYlMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15367   1 TLFPVVYILVLVVGLPANCLSLY-YGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICGIL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLpsAIFSTTVKV 241
Cdd:cd15367  80 LYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMK---------------AATLVSTVIWLKELMTCV--FFFLHGEIS 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEE---LCLVRFPDKLLGRDRQFWlglyhsqKVLLGFVLPLGIIILCYLLLVRFIadRRAAGTKggaavaggrptgasA 318
Cdd:cd15367 143 KDKEnhsVCFEHYPIKAWEHNINYY-------RFYAGFLFPIFLLSFSYCRILRAV--RKSHGTQ--------------K 199
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20455271 319 RRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVpFSQEYFlcqvYAFPVSVCLAHSNSCLNPVLYCLV 392
Cdd:cd15367 200 SQKIQIKRLVLSTVVIFLVCFGPYHILLLVRSVFERDCN-FAEGIF----NYYHFSLLLTSFNCVADPVLYCFA 268
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
87-392 1.60e-14

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 73.68  E-value: 1.60e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  87 VYWVVCALGLAGNLLVLYlMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNM 166
Cdd:cd15366   6 LYIIVIVLGLPTNCLALW-AAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 167 YASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFSTTVK-VMGEE 245
Cdd:cd15366  85 YISIAFLCCISVDRYLAVAHPLRFAKVRR---------------VKTAVAVSAVVWAIEIGANSAPLFHDELFRdRYNHT 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 246 LCLVRFPdkllgrdRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRfiADRRAAGTKggaavaggRPTGASARRLSkvt 325
Cdd:cd15366 150 FCFEKYP-------MEDWVAWMNLYRVFVGFLFPWVLMLFSYRGILR--AVRGNVSTE--------QQEKAKIKRLA--- 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 326 KSVTIVVLsffLCWLPNQAL---TTWSILIKFNAVPFSQEYFLcqvyAFPVSVCLAHSNSCLNPVLYCLV 392
Cdd:cd15366 210 LSLIAIVL---LCFAPYHVLllsRSVVYLGKPCDCGFEERVFT----AYHVSLALTSLNCVADPILYCLV 272
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
90-400 1.81e-14

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 73.42  E-value: 1.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMKSmQGWRKSSINLFVTNLALTDFQFVL--TLPFWAvenaLDFKWPF--GKAMCKIVSMVTSMN 165
Cdd:cd15196   9 TILVLALFGNSCVLLVLYR-RRRKLSRMHLFILHLSVADLLVALfnVLPQLI----WDITYRFygGDLLCRLVKYLQVVG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYHSVA---SALKSHRTRGHgrgdccgrslgdscCFSAKAlcvwiWALAALASLPSA-IFSTTVKV 241
Cdd:cd15196  84 MYASSYVLVATAIDRYIAIChplSSHRWTSRRVH--------------LMVAIA-----WVLSLLLSIPQLfIFSYQEVG 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFpdkllgrdRQFW-LGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAagtkggaavaggrptgasarr 320
Cdd:cd15196 145 SGVYDCWATF--------EPPWgLRAYITWFTVAVFVVPLIILAFCYGRICYVVWRAKI--------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 lsKVTKSVTIVVLSFFLCWLPnqalttwsilikfnavpfsqeYFLCQVY------------AFPVSVCLAHSNSCLNPVL 388
Cdd:cd15196 196 --KTVKLTLVVVACYIVCWTP---------------------FFVVQMWaawdptapiegpAFVIIMLLASLNSCTNPWI 252
                       330
                ....*....|..
gi 20455271 389 YCLVRREFRKAL 400
Cdd:cd15196 253 YLAFSGNLRRAL 264
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
86-398 2.10e-14

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 73.14  E-value: 2.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLY-LMKSMQGWRKSSInlFVTNLALTDFQFVLTLPFWAVenALDFKWPFGKAMCKIVSMVTSM 164
Cdd:cd15165   5 VVYIPTFVLGLLLNLMALWvFLFKIKKWTESTI--YMINLALNDLLLLLSLPFKMH--SSKKQWPLGRTLCSFLESLYFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSV-----ASALKSHRtrghgrgdccgrslgdsccfSAKALCVWIWALAALASLPsaIFSTTV 239
Cdd:cd15165  81 NMYGSILIIVCISVDRYIAIrhpflAKRLRSPR--------------------KAAIVCLTIWVFVWAGSIP--IYSFHD 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFPDKLLGrdrqFWLGLYhsqKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavaggrptgasar 319
Cdd:cd15165 139 KPTNNTRCFHGFSNKTWS----KKVIVV---VEEFGFLIPMAVMVFCSVQIIRTLLDMRRPEQP---------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 rLSKVTKSVTIVVLS---FFLCWLPNQAlttwSILIKFNAvpfSQEYF-LCQV-----YAFPVSVCLAHSNSCLNPVLYC 390
Cdd:cd15165 196 -KVKQNKSVKIVLSNlvvFLVCFTPYHL----GIFLQFLV---KNDIInDCSTkqsirLFVQVSMCLANVNCCLDAICYY 267

                ....*...
gi 20455271 391 LVRREFRK 398
Cdd:cd15165 268 FILKEFRE 275
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
84-400 2.86e-14

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 73.31  E-value: 2.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNL-LVLYLMKsmQGWRKSSINLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKIVSMV 161
Cdd:cd15395   3 LALAYSAVIILGVSGNLaLIIIILK--QKEMHNVTNILIVNLSFSDLLMtIMCLPFTFVYTLMD-HWVFGEAMCKLNSMV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVasaLKSHRTRGHGRGDCCGRSLgdsccfsakalcvwIWALAALASLPSAIFSTTV-- 239
Cdd:cd15395  80 QCISITVSIFSLVLIAIERHQLI---INPRGWRPNNRHAYVGIAV--------------IWVLAVLTSLPFLIFQVLTde 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 ----------KVMGEELCLVRFPdkllgrDRQFWLGlYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaava 309
Cdd:cd15395 143 pfknvnvsldAYKGKYVCLDQFP------SDTIRLS-YTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNMMDK------ 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 310 gGRPTGASARRLSKVTKSVTIVVLSFFLCWLPnqalttwsiLIKFNAV-PFSQEYFLCQVYAFPVSVC--LAHSNSCLNP 386
Cdd:cd15395 210 -MRDNKYRSSETKRINIMLISIVVAFAVCWLP---------LNIFNAVfDWNHEAIATCNHNLLFLIChlTAMISTCVNP 279
                       330
                ....*....|....
gi 20455271 387 VLYCLVRREFRKAL 400
Cdd:cd15395 280 IFYGFLNKNFQRDL 293
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
82-400 3.66e-14

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 72.75  E-value: 3.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWAVeNALDFKWPFGKAMCKIVSM 160
Cdd:cd15051   1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLT-NYFIVSLAVTDLLLgLLVLPFSAI-YELRGEWPLGPVFCNIYIS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfSAKALC-VWIWALaALASLPSAI----F 235
Cdd:cd15051  79 LDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRR--------------VAIALAaIWVVSL-AVSFLPIHLgwntP 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 STTVKVMGEelclvrfpdkllGRDRQFWLGLYHSQKVLLG-FVLPLGIIILCYL---LLVRFIADRRAAGTKGGAAVAGG 311
Cdd:cd15051 144 DGRVQNGDT------------PNQCRFELNPPYVLLVAIGtFYLPLLIMCGVYLrifRIAREQAKRINALTPASTANSSK 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 RPTGASARrlsKVTKSVTIVVLSFFLCWLPNQALTTWSilikfnavPFSQEYFLCQVYAfpVSVCLAHSNSCLNPVLYCL 391
Cdd:cd15051 212 SAATAREH---KATVTLAAVLGAFIICWFPYFTYFTYR--------GLCGDNINETALS--VVLWLGYANSALNPILYAF 278

                ....*....
gi 20455271 392 VRREFRKAL 400
Cdd:cd15051 279 LNRDFRRAF 287
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
86-399 3.77e-14

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 72.29  E-value: 3.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMKS-MQGWRKSSInlFVTNLALTDFQFVLTLPFwaVENALDFKWPfGKAMCKIVSMVTSM 164
Cdd:cd15164   5 IIYIPILFFGLLFNVLALWVFCCkMKKWTETRV--YMINLAVADCCLLFSLPF--VLYFLKHSWP-DDELCLVLQSIYFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAalasLPSAIFSTTVKVMGE 244
Cdd:cd15164  80 NRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRK---------------AALTCGLLWVLV----IISVSLRLAWEEQEE 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 245 ELCLVRfpdklLGRDRQFWLGLYhsqkVLLGFVLPLGIIILCYLLLVRFIADRRAagtkggaavaggrpTGASARRLSKv 324
Cdd:cd15164 141 NFCFGK-----TSTRPSKRTLIF----SLLGFFIPLIILSFCSIQVIRSLKKKKK--------------TNPHEEKLIQ- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 325 tKSVTIV---VLSFFLCWLPNQAlttwSILIKFNAVPFSQEYFLCQVY--AFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15164 197 -KAIYIVsanLIVFIVCFLPLHI----GLLVRFVMESNKASCSLIQNIrnFIYVASCLANANCCLDAICYYFVAKEFQEA 271
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
83-399 4.11e-14

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 72.77  E-value: 4.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTD-FQFVLTLPFwAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15065   1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKS-NLFIVSLAVADlLVALLVMTF-AVVNDLLGYWLFGETFCNIWISF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALAS-LP--------- 231
Cdd:cd15065  79 DVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRR---------------ALVVIASVWILSALISfLPihlgwhrls 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 232 -SAIFSTTVKVMGEELCLVRFPdkllgrdrqFWLGLYHSqkvLLGFVLPLGIIILCYLLL-------VRFIADRRAAGTK 303
Cdd:cd15065 144 qDEIKGLNHASNPKPSCALDLN---------PTYAVVSS---LISFYIPCLVMLLIYSRLylyarkhVVNIKSQKLPSES 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 304 GGAAVAGGRPTGASARRLS--KVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEyflcqvyAFPVSVCLAHSN 381
Cdd:cd15065 212 GSKFQVPSLSSKHNNQGVSdhKAAVTLGIIMGVFLICWLP---FFIINIIAAFCKTCIPPK-------CFKILTWLGYFN 281
                       330
                ....*....|....*...
gi 20455271 382 SCLNPVLYCLVRREFRKA 399
Cdd:cd15065 282 SCLNPIIYSIFNSEFRRA 299
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
86-400 4.56e-14

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 72.59  E-value: 4.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGL---AGNLLVLylmksmqgwrkSSI----------NLFVTNLALTDFqFV--LTLPFWAVENAlDFKWPF 150
Cdd:cd15055   2 LLYIVLSSISLltvLGNLLVI-----------ISIshfkqlhtptNLLLLSLAVADF-LVglLVMPFSMIRSI-ETCWYF 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 151 GKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASL 230
Cdd:cd15055  69 GDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRR---------------VKICICLCWFVSALYSS 133
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 231 PSAIFSTTVKVMGEEL-----CLVRFpdkllgrdrQFWLGLYHSqkvLLGFVLPLGIIILCYLllVRFIADR---RAAGT 302
Cdd:cd15055 134 VLLYDNLNQPGLIRYNscygeCVVVV---------NFIWGVVDL---VLTFILPCTVMIVLYM--RIFVVARsqaRAIRS 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 303 KGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSqeyflcqvyAFPVSVCLAHSNS 382
Cdd:cd15055 200 HTAQVSLEGSSKKVSKKSERKAAKTLGIVVGVFLLCWLP---YYIVSLVDPYISTPSS---------VFDVLIWLGYFNS 267
                       330
                ....*....|....*...
gi 20455271 383 CLNPVLYCLVRREFRKAL 400
Cdd:cd15055 268 CLNPLIYALFYPWFRKAL 285
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
84-400 8.35e-14

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 71.82  E-value: 8.35e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQ-FVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15357   3 MSLVYAVIFVVGVIGNLLVCLVILKHQN-MKTPTNYYLFSLAVSDLLvLLFGMPLEVYEMWSNYPFLFGPVGCYFKTALF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRY----HSVASALKSHRTRghgrgdccgrslgdsccfsAKALCVWIWALAALASLPSA----- 233
Cdd:cd15357  82 ETVCFASILSVTTVSVERYvailHPFRAKLNSTRER-------------------ALKIIVVLWVLSVLFSIPNTsihgi 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 234 ---IFSTTVKVMGEELCLVRFPdkllgrdrqFWLGLYHSQ-KVLLGFVLPLGII-ILCYLLLVRFIADRRAAGTKGGAAV 308
Cdd:cd15357 143 klqYFPNGTLIPDSATCTVVKP---------LWIYNLIIQiTSLLFYVLPMGVIsVLYYLMGLKLRGDKSLEADEMNVNI 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 309 AggRPTGASarrlskVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVyafpVSVCLAHSNSCLNPVL 388
Cdd:cd15357 214 Q--RPSRKS------VTKMLFVLVLVFAICWAPFHVDRLFFSFVVEWTEPLANVFNLIHV----VSGVFFYLSSAVNPII 281
                       330
                ....*....|..
gi 20455271 389 YCLVRREFRKAL 400
Cdd:cd15357 282 YNLLSRRFRTAF 293
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
84-399 8.50e-14

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 71.65  E-value: 8.50e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTS 163
Cdd:cd15148   3 LAVFYSLIFLFGLVGNLLALWVFLFIHR-KRNSVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGNLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 164 MNMYASVFFLTAMSVTRYhsvasaLKSHRTrghgrgdCCGRSLGDSCCfSAKALCVwIWALAALASLPSAIfsTTVKVMG 243
Cdd:cd15148  82 MNMYISIILLGFISLDRY------LKINRS-------SRRQKFLTRKW-SIVACGV-LWAVALVGFVPMIV--LTEKNEE 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 EELCLvRFPDKLLGRdrqfWLGLYHSQKVLLgFVLPLGIIILCYLLLVR--FIADRRaagtkggaavaggRPTGASARRL 321
Cdd:cd15148 145 STKCF-QYKDRKNAK----GKAIFNFLIVAM-FWLVFLLLILSYGKIAKklLRISRD-------------KPDFPNAAKY 205
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNavPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15148 206 NRTARKSFFVLFIFTVCFVPYHAFRIFYITSQLQ--NNSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRKV 281
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
83-400 9.16e-14

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 71.45  E-value: 9.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLTLPFWAVeNALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15079   2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPS-NMLVVNLAISDFLMMIKMPIFIY-NSFYEGWALGPLGCQIYAFLG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVA---SALKSHRTRghgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFsttv 239
Cdd:cd15079  80 SLSGIGSIWTNAAIAYDRYNVIVkplNGNPLTRGK-------------------ALLLILFIWLYALPWALLPLLF---- 136
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 kVMGeelclvRF-PDKLLG--------RD---RQFWLGLYhsqkvLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAa 307
Cdd:cd15079 137 -GWG------RYvPEGFLTscsfdyltRDwntRSFVATIF-----VFAYVIPLIIIIYCYSFIVKAVFAHEKALREQAK- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 308 vaggRPTGASARRLS---------KVTKSVTIVVLSFFLCWLPnqalttwSILIKFNAVPFSQEYFLCQVYAFPvsVCLA 378
Cdd:cd15079 204 ----KMNVVSLRSNAdankqsaeiRIAKVALTNVFLWFIAWTP-------YAVVALIGAFGNQSLLTPLVSMIP--ALFA 270
                       330       340
                ....*....|....*....|..
gi 20455271 379 HSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15079 271 KTAACYNPIVYAISHPKYRLEL 292
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
81-400 9.33e-14

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 71.96  E-value: 9.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  81 RILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQF-VLTLPFWAVENALDFkWPFGkAMCKIVS 159
Cdd:cd15320   1 RVLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVaVLVMPWKAVAEIAGF-WPFG-SFCNIWV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgrslgdsccFSAKALCVWI---WALAALASL------ 230
Cdd:cd15320  79 AFDIMCSTASILNLCVISVDRYWAISSPFRYERK------------------MTPKVAFIMIsvaWTLSVLISFipvqln 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 231 -----PSAIFSTTVKVMGEEL--ClvrfpDKLLGRdrqfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIA-------- 295
Cdd:cd15320 141 whkakPTSFLDLNASLRDLTMdnC-----DSSLNR-------TYAISSSLISFYIPVAIMIVTYTRIYRIAQkqirrisa 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 296 -DRRAAGTKGGAAVAGGRPTGA----------SARRLSKVTKSVTIVVLSFFLCWLPNQALttwSILIKFnAVPFSQEYF 364
Cdd:cd15320 209 lERAAVHAKNCQNSTGNRGSGDcqqpessfkmSFKRETKVLKTLSVIMGVFVCCWLPFFIL---NCMVPF-CKPTSTEPF 284
                       330       340       350
                ....*....|....*....|....*....|....*.
gi 20455271 365 LCQVYAFPVSVCLAHSNSCLNPVLYCLvRREFRKAL 400
Cdd:cd15320 285 CISSTTFDVFVWFGWANSSLNPIIYAF-NADFRKAF 319
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
82-397 1.08e-13

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 71.36  E-value: 1.08e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKS-MQGWRKSSINLFvtNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15199   1 IAYASLLILEFGLGLPGNAIALWTFIFrLKVWKPYAVYLL--NLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVAsalkshrtrgHGRGDCCGRSLGdsccfSAKALCVWIWALAALASLPSAIFSttvK 240
Cdd:cd15199  79 MLSLSRGVSIAFLTAVALDRYFRVV----------HPRGKKNSLSLQ-----AAPYISFLVWLLLVGLTIPTLLAS---Q 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFPdkllgRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavaggrptgasARR 320
Cdd:cd15199 141 PKNFTECNSFSP-----KDDEDFSDTWQEAVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDVGK--------------QPK 201
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNqalTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15199 202 LQRAMALVTSVVVVFGFCFLPC---FLARVLMLIFQNKESCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
83-399 1.08e-13

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 70.85  E-value: 1.08e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVT-NYFIVSLAVADLLVgSIVMPFSILHEMTGGYWLFGRDWCDVWHSF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALkSHRTR-GHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15067  80 DVLASTASILNLCVISLDRYWAITDPI-SYPSRmTKRR---------------ALIMIALVWICSALISFPAIAWWRAVD 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 --VMGEELCLvrFPDKLLgrdrqfwlglYHSQKVLLGFVLPLGIIILCYLLLVRFIA-DRRAAGTKGgaavaggrptgas 317
Cdd:cd15067 144 pgPSPPNQCL--FTDDSG----------YLIFSSCVSFYIPLVVMLFTYYRIYRAAAkEQKAAKTLG------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 arrlskvtksvtIVVLSFFLCWLPNQALTtwsILIKFN-AVPFSQEYFLcqvyaFPVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15067 199 ------------IVMGVFILCWLPFFVTN---ILIGFCpSNCVSNPDIL-----FPLVTWLGYINSGMNPIIYACSSRDF 258

                ...
gi 20455271 397 RKA 399
Cdd:cd15067 259 RRA 261
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
82-399 1.50e-13

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 71.00  E-value: 1.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKIVSM 160
Cdd:cd15399   1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVT-NFFIANLAVADLMVnTLCLPFTLVYTLLD-EWKFGAVLCHLVPY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdSCCFSAKALCvwiWALAALASLPSAIFST-TV 239
Cdd:cd15399  79 AQALAVHVSTVTLTVIALDRHRCIVYHLESKISK--------------KISFLIIGLT---WAASALLASPLAIFREySV 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFPDKLLGRDRQFWLgLYHSQKVLLGFVLPLGIIILCYLllvrfiadRRAAGTKGGAAVAGGRPTGASAR 319
Cdd:cd15399 142 IEISPDFKIQACSEKWPNGTLNDGT-IYSVSMLLIQYVLPLAIISYAYI--------RIWTKLKNHVSPGGGNDHYHQRR 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RlsKVTKSVTIVVLSFFLCWLPNQALTTWS----ILIKFNavpfsqEYFLCQVYAFPVSVClahsNSCLNPVLYCLVRRE 395
Cdd:cd15399 213 R--KTTKMLVCVVVVFAVSWLPFHAFQLASdidsKVLDLK------EYKLIYTIFHVIAMC----STFANPLLYGWMNNN 280

                ....
gi 20455271 396 FRKA 399
Cdd:cd15399 281 YRTA 284
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
82-400 2.17e-13

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 70.54  E-value: 2.17e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMkSMQGWRKSSINLFVTNLALTDFQF-VLTLPFWAVENALDFkWPFGKAMCKIVSM 160
Cdd:cd15397   1 VFLVVSYSLVMAVGLLGNICLICVI-ARQKEKTNVTNILIANLSFSDILVcLVCLPFTVVYTLMDY-WIFGEVLCKMTPF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLtamsvtryhsVASALKSHRTRGHGRGdccgrslGDSCCFSAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15397  79 IQCMSVTVSILSL----------VLIALERHQLIINPTG-------WKPSVSQAYLAVVVIWMLACFISLPFLAFHILTD 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVRFP--DKLLGRD----RQFWLgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAavAGGRPT 314
Cdd:cd15397 142 EPYKNLSHFFAPlaDKAVCTEswpsEHHKL-AYTTWLLLFQYCLPLLFILVCYLRIYLRLRRRKDMLERRGE--YNRRAG 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 315 GasarrLSKVTKSVTIVVLSFFLCWLPnqalttwsiLIKFNAV-PFSQEYFLCQVYAFPVSVC--LAHSNSCLNPVLYCL 391
Cdd:cd15397 219 H-----SKRINVMLVSLVAAFALCWLP---------LNVFNAIaDWNHEAIPHCQHNLIFSLChlAAMASTCVNPIIYGF 284

                ....*....
gi 20455271 392 VRREFRKAL 400
Cdd:cd15397 285 LNSNFKKEV 293
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
86-400 2.55e-13

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 70.21  E-value: 2.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFW-AVENaldfkWPFGKAMCKIVSMVTSM 164
Cdd:cd15920   5 VMYSIICIVGLLSNTLALWVFFLRQQ-RETSISVYMRNLALADLLLVLCLPFRvAYQN-----TAGPLSFCKIVGAFFYL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALKSHRtrghgrgdccgrsLGDSCCFSAKALCVWIWALAALasLPsAIFSTTVKVMGE 244
Cdd:cd15920  79 NMYASILFLSLISLDRYLKIIKPLQQFK-------------IHTVPWSSAASGGVWLLLLACM--IP-FLFESRNEGPCD 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 245 ELCLvrfpdkllgrdrqfwlgLYHSQKVLLGFV--LPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRLS 322
Cdd:cd15920 143 NKCF-----------------HFRSKGLTAGGInlTAVVIFYILSLLFLYFYAKISHKLYKVSLGNAQQQIKKASKRAII 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 323 KvtksvTIVVLSFF-LCWLPNQALTTWSILIKFN---AVPFSQEYFLcqvyAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15920 206 K-----TFIVLAIFiVCFVPYHIVRVPYVLAQIDvisSLPWKQTLHI----ANELVLCLSALNSCLDPIIYFFLSSSFRR 276

                ..
gi 20455271 399 AL 400
Cdd:cd15920 277 AV 278
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
84-399 9.13e-13

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 68.71  E-value: 9.13e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLT-LPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15133   3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPT-NYYLFSLAVSDLLVLLLgMPLELYELWQNYPFLLGSGGCYFKTFLF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSH--RTRGHGRgdccgRSLGdsccfsakalCVWIWAL--AALASLPSAIFSTT 238
Cdd:cd15133  82 ETVCLASILNVTALSVERYIAVVHPLAARtcSTRPRVT-----RVLG----------CVWGVSMlcALPNTSLHGIKFLG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEELCLVRFPDKLLGRDRQfwlglyhsQKVLLGFVLPLGII-ILCYLLLVRFIADRRAAGTkgGAAVAGGRPTG-- 315
Cdd:cd15133 147 SGVPASAQCTVRKPQAIYNMIPQ--------HTGHLFFVLPMAVIsVLYLLMALRLARERGLDAT--GAGSKIGTRTGql 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 -ASARRLSKVTKSVTIVVLSFFLCWLPNQA-LTTWSILIKfnavpFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVR 393
Cdd:cd15133 217 lQHPRTRAQVTKMLFILVVVFAICWAPFHIdRLMWSFISD-----WTDNLHEVFQYVHIISGVFFYLSSAVNPILYNLMS 291

                ....*.
gi 20455271 394 REFRKA 399
Cdd:cd15133 292 TRFREM 297
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
82-292 1.28e-12

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 68.06  E-value: 1.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15170   1 WLVLAVYIITFLIGLPANLLAFYTFIRKVRRKPTPIDILLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKsHRTRGHgrgdccgrslgdscCFSAKALCVWIWALAAL-ASLPSAI----FS 236
Cdd:cd15170  81 FFSTIYISTLFLTAISVERYLGVAFPIK-YKLRRR--------------PLYAVIASVFFWVLAFShCSIVYIVeyhiDS 145
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20455271 237 TTVKVMGEELCLVRFPDKLLGRDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVR 292
Cdd:cd15170 146 ENTSVTNNSRCYDNFTPEQLKILLPVRLEL-----FLVLFCIPFLITCFCYINFIR 196
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
82-398 1.39e-12

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 67.88  E-value: 1.39e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFqFVLTLPFWAVENALDFK-WPFGKAMCKIVSM 160
Cdd:cd15209   1 SALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAG-NIFVVSLSVADL-VVAIYPYPLILHAIFHNgWTLGQLHCQASGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgRSLGDSCCFsakaLCVwIWALAALASLP--------- 231
Cdd:cd15209  79 IMGLSVIGSIFNITAIAINRYCYICHSLQYDRL----------YSLRNTCCY----LCL-TWLLTVLAVLPnffigslqy 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 232 -----SAIFSTTVKVMgeelclvrfpdkllgrdrqfwlglYHSQKVLLGFVLPLGIIILCYL-LLVRFIADRRAAgtkgg 305
Cdd:cd15209 144 dpriySCTFAQTVSTV------------------------YTITVVVIHFLLPLLIVSFCYLrIWVLVLQVRQRV----- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 306 aavaggRPTGASARRLSKVTKSVT--IVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFlcqvyaFPVSVCLAHSNSC 383
Cdd:cd15209 195 ------KPDQRPKLKPADVRNFLTmfVVFVLFAVCWAPLNFIGLAVAINPKEMAPKIPEWL------FVASYFMAYFNSC 262
                       330
                ....*....|....*
gi 20455271 384 LNPVLYCLVRREFRK 398
Cdd:cd15209 263 LNAIIYGLLNQNFRK 277
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
83-400 1.42e-12

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 68.00  E-value: 1.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENAL--------DFKWpFGKAM 154
Cdd:cd15137   2 VLRVFIWVVGIIALLGNLFVL-IWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIASVDLYyrgvyikhDEEW-RSSWL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 155 CK---IVSMVTSMnmyASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccGRSlgdsccfSAKALCVWIWALA-ALASL 230
Cdd:cd15137  80 CTfagFLATLSSE---VSVLILTLITLDRFICIVFPFSGRRL---------GLR-------RAIIVLACIWLIGlLLAVL 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 231 PsaifsttvkvmgeeLCLVRFPDKLLGR---------DRQFWLGLYHSQKVLLGF-VLPLGIIILCYLLLvrFIADRRaa 300
Cdd:cd15137 141 P--------------LLPWDYFGNFYGRsgvclplhiTDERPAGWEYSVFVFLGLnFLAFVFILLSYIAM--FISIRR-- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 301 gtkggaavAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSilikFNAVPFSQEyflcqVYAFpVSVCLAHS 380
Cdd:cd15137 203 --------TRKAAASRKSKRDMAVAKRFFLIVLTDFLCWIPIIVIGILA----LSGVPIPGE-----VYAW-VAVFVLPI 264
                       330       340
                ....*....|....*....|
gi 20455271 381 NSCLNPVLYCLVRREFRKAL 400
Cdd:cd15137 265 NSALNPILYTLSTPKFRKKL 284
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
83-399 1.49e-12

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 67.39  E-value: 1.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWAVENALDFkWPFGKAMCKIVSMV 161
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTIT-NCYIVSLATADLLVgVLVLPLAIIRQLLGY-WPLGSHLCDFWISL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgRSLGdsccfSAKALCVWIWALAaLASLPSAIFSTTVKV 241
Cdd:cd15061  79 DVLLCTASILNLCCISLDRYFAITYPLKYRTKRS--------RRLA-----ITMILAVWVISLL-ITSPPLVGPSWHGRR 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDkllgrdrqfwlglYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgasarrl 321
Cdd:cd15061 145 GLGSCYYTYDKG-------------YRIYSSMGSFFLPLLLMLFVYLRIFRVIAKER----------------------- 188
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 322 sKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYFLCQVYafpvsvcLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15061 189 -KTAKTLAIVVGCFIVCWLP---FFIMYLIEPFCDCQFSEALSTAFTW-------LGYFNSVINPFIYAFYNKDFRRA 255
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
82-400 1.92e-12

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 67.47  E-value: 1.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwrKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15924   1 QLFPVLYTVIFFAGILLNGLAMWIFFHIPS--KSSFIIYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdSCCFsAKALCVWIWALAALASLPSAIFstTVKV 241
Cdd:cd15924  79 FYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPK--------------SVSF-AKILSVVVWALMFLLSLPNMIL--TNQQ 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEElcLVRFPDKLLGRDRQFWLGLYHSQKVLLgFVLPLGIIILCYLLLVRFI--ADRRAAGTKggaavaggrptgASAR 319
Cdd:cd15924 142 PREK--NVKKCSFLKSELGLKWHEIVNYICQVI-FWIVFLLMIVCYTAITKKVyrSYRRVFRSS------------SSRR 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RlsKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCqVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15924 207 K--KSNVKIFIIVAVFFVCFVPYHFARIPYTLSQTRDVFDCTAENIL-FYVKEATLFLSALNVCLDPIIYFFLCKSFRES 283

                .
gi 20455271 400 L 400
Cdd:cd15924 284 L 284
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
90-399 2.33e-12

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 66.95  E-value: 2.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLyLMKSMQGWRKSSINLFVTNLALTD-FQFVLTLPFWAVENALDFKWPFGKAMCKI-----VSMVTs 163
Cdd:cd15052   9 LLVIATIGGNILVC-LAISLEKRLQNVTNYFLMSLAIADlLVGLLVMPLSILTELFGGVWPLPLVLCLLwvtldVLFCT- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 164 mnmyASVFFLTAMSVTRYHSVASALKshrtrgHGRGDCCGRSLgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVMG 243
Cdd:cd15052  87 ----ASIMHLCTISLDRYMAIRYPLR------TRRNKSRTTVF-------LKIAIVWLISIGISSPIPVLGIIDTTNVLN 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 EELCLVRFPDKLLgrdrqfwlglYHSqkvLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgasarrlsK 323
Cdd:cd15052 150 NGTCVLFNPNFVI----------YGS---IVAFFIPLLIMVVTYALTIRLLSNEQ------------------------K 192
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20455271 324 VTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEyflcqvyAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15052 193 ASKVLGIVFAVFVICWCPFFITNILTGLCEECNCRISPW-------LLSVFVWLGYVSSTINPIIYTIFNKTFRRA 261
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
82-400 2.42e-12

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 67.52  E-value: 2.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVS-- 159
Cdd:cd14996   1 VALPIIYSFLFVTGVFGNLLSLWVFLTKIS-KKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANff 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 --MVTSMNMYASVFFLTAMSVTRYHSVASalKSHRTRGHGRGDCC--GRSLGDsccFS----AKALCVWIWALAALASLP 231
Cdd:cd14996  80 gtLVIHVSMCVSILILSWIAISRYATLMK--HDSATQKQSCYEKIfyGHFLKR---FRqpkfARYLCIYIWGVVLCIIIP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 232 SAIFSTTVKVM--GEELCLvrfpdkllgrDRQFWLGLYHSQ---KVLLGFVLPLGIIILC-YLLLVRFIADRRAAgtkgg 305
Cdd:cd14996 155 VVVYYSVREADedGESLCY----------NRQVELGAKGSQiagLIATTFFFLFFLVVLLsYYSFVNHLRRIQKN----- 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 306 AAVAGgrptgaSARRLSKVTKSVTIVVLSFFLCWLPnqalttWSILIKFNAVPFSQEYflCQVYAFPVSV-----CLAHS 380
Cdd:cd14996 220 TCISE------KDLIYRSVKRNILIIQALLVVCFLP------YHIFKPVFYVLHQRED--CQQLNYLIETkniltCLASA 285
                       330       340
                ....*....|....*....|
gi 20455271 381 NSCLNPVLYCLVRREFRKAL 400
Cdd:cd14996 286 RSSTDPIMYLLLDKTFKKTL 305
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
82-400 3.07e-12

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 67.15  E-value: 3.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMksMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15150   1 VIFPLLYTVLFIVGLTMNGLAMRVF--FQIPSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgRSLGdsccfsAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15150  79 FYFTMYISILFLGLITIDRYQKTTRPFKTSNPK---------NLLG------AKILSTVIWASMFALSLPNMILTNRQPT 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEelclvRFPDKLLGRDrqfwLGLYHSQKV----LLGFVLPLGIIILCYLLLVRFIADrraagtkggaAVAGGRPTGAS 317
Cdd:cd15150 144 PKN-----VKKCSLLKSE----FGLVWHEIVnyicQVIFWVNFLIVIVCYTLITKELYK----------SYKRTRGVGKV 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRlsKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPF-SQEYFLcqVYAFPVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15150 205 SRK--KVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDcTAKNTL--FYVKESTLWLTSLNACLDPFIYFFLCKSF 280

                ....
gi 20455271 397 RKAL 400
Cdd:cd15150 281 RNSL 284
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
84-400 3.33e-12

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 67.05  E-value: 3.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLT-LPFWAVeNALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15336   3 VGSVILIIGITGMLGNALVIYAFCRSKKLRTPA-NYFIINLAVSDFLMSLTqSPIFFV-NSLHKRWIFGEKGCELYAFCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGdccgrslgdsccfSAKALCVWIWALAalASLPsAIFSTTVKVm 242
Cdd:cd15336  81 ALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRA-------------MIIILLVWLYSLA--WSLP-PLFGWSAYV- 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 geelclvrfPDKLLGR---DRQFWLGLYHSQKVLLG---FVLPLGIIILCYLLLVRFIadrRAAGTKGGAAVAGGRPTGA 316
Cdd:cd15336 144 ---------PEGLLTSctwDYMTFTPSVRAYTMLLFcfvFFIPLGIIIYCYLFIFLAI---RSTGREVQKLGSQDRKEKA 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 SARRLS----KVTKSVTIVVLSFFLCWLPNQ--ALTTWSILIKFnAVPFSQEyflcqvyafpVSVCLAHSNSCLNPVLYC 390
Cdd:cd15336 212 KQYQRMknewKMAKIAFVVILLFVLSWSPYAcvALIAWAGYAHL-LTPYMKS----------VPAVIAKASAIYNPIIYA 280
                       330
                ....*....|
gi 20455271 391 LVRREFRKAL 400
Cdd:cd15336 281 ITHPKYREAI 290
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
83-392 3.95e-12

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 66.34  E-value: 3.95e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLmKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15365   2 LFPFVYIFVIVISIPSNCISLYV-SCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALK-SH-RTRGhgrgdccgrslgdsccfSAKALCVWIWALAALAslpSAIFSTTVK 240
Cdd:cd15365  81 YTNFYTSTALLTCIALDRYLAVVHPLKfMHlRTIR-----------------TALSVSVAIWLLEICF---NAVILTWED 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEE----LCLVRFPDKLlgrdrqfWLGLYHSQKVLLGFVLPLGIIILCYlllvrfiadrraagTKGGAAVAGGRPTGA 316
Cdd:cd15365 141 SFHESsshtLCYDKFPLED-------WQARLNLFRICLGYLLPLLIILFCY--------------WKIYQAVRSNQATED 199
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20455271 317 SARRlsKVTKSVTIVVLSFFLCWLPNQALttwsILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLV 392
Cdd:cd15365 200 QEKK--KIFKLLLLITVTFVICFTPYHVV----LLIRSIVEPCDCRNAKWLYTLYKITVALTSLNCIADPFLYCFV 269
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
84-398 3.99e-12

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 66.72  E-value: 3.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLL---VLYLMKSMqgwrKSSINLFVTNLALTDFQ-FVLTLPFWAVENALDFKWPFGKAMCKIVS 159
Cdd:cd15358   3 VCVTYLLIFVVGAVGNGLtciVILRHKVM----RTPTNYYLFSLAVSDLLvLLLGMPLELYEMWSNYPFLLGAGGCYFKT 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASAL--KSHRTRGHgrgdccgrslgdsccfsAKALCVWIWALAALASLPS----A 233
Cdd:cd15358  79 LLFETVCFASILNVTALSVERYIAVVHPLkaKYVVTRTH-----------------AKRVIGAVWVVSILCSIPNtslhG 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 234 IFSTTVKVMGeelclvRFPDK---LLGRDRQFWlGLYHSQKVLLGFVLPLGIIILCYLLL-VRFIADR--RAAGTKGGAA 307
Cdd:cd15358 142 IFQLTVPCRG------PVPDSatcMLVKPRWMY-NLIIQITTLLFFFLPMGTISVLYLLIgLQLKREKmlLVLEAKGSKA 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 308 VAG--GRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQA-LTTWSILIKfnavpFSQEYFLCQVYAFPVSVCLAHSNSCL 384
Cdd:cd15358 215 GDSyqHRRIQQEKRRRRQVTKMLFVLVVVFGICWAPFHTdRLMWSFISQ-----WTGELHLAFQYVHIISGVFFYLSSAA 289
                       330
                ....*....|....
gi 20455271 385 NPVLYCLVRREFRK 398
Cdd:cd15358 290 NPVLYNLMSTRFRE 303
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
86-399 4.57e-12

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 66.25  E-value: 4.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLT--LPFWAVENALDFKWPFGKAMCKIVSMVTS 163
Cdd:cd14995   5 FLVLLICGVGIVGNIMVVLVVLRTRHMR-TPTNCYLVSLAVADLMVLVAagLPNEIESLLGPDSWIYGYAGCLLITYLQY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 164 MNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgrslgdsCCFS-AKALCVWIWALAALASLPSAIFSTTVKVM 242
Cdd:cd14995  84 LGINASSLSITAFTIERYIAICHPMKAQFI----------------CTVSrAKKIICFVWIFTSLYCSPWLFLLDLSIKH 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 GEELCLVRFPDKLlgrDRQFWLGLYHSQKVLLgFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggrptgaSARRls 322
Cdd:cd14995 148 YGDDIVVRCGYKV---SRHYYLPIYLADFVLF-YVIPLLLAIVLYGLIGRILF---------------------SSRK-- 200
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 323 KVTKSVTIVVLSFFLCWLPNQALTTWSiliKFNAVPFSQEYFLcqvyaFPVSVCLaHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd14995 201 QVTKMLAVVVVLFALLWMPYRTLVVYN---SFASPPYLDLWFL-----LFCRTCI-YLNSAINPILYNLMSQKFRAA 268
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
87-389 8.29e-12

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 65.56  E-value: 8.29e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  87 VYWVVCALGLAGNLLVLY-LMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMN 165
Cdd:cd15398   6 LYTFISLLGFLGNLLILTaLTKKWK--QKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsakALCVWIWALAALASLPSAIFSTTVK----- 240
Cdd:cd15398  84 VMVSTLMLMSIAIVRYHMIKHPLSNHLTANHGY-----------------FLLGTVWTLGFTICSPLPVFHKIVDlsetf 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 ----VMGEELCLVRFPDKllGRDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrptga 316
Cdd:cd15398 147 nlesLKNKYLCIESWPSD--SYRIAFTISL-----LFVQYILPLVCLTVSHTSVCR------------------------ 195
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 317 SARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYFLCqVYafpvsvCLAH----SNSCLNPVLY 389
Cdd:cd15398 196 SVKRSRSVFYRLTIVILAFAVSWMP---LHLFHLVTDFNANLISNRHFKL-VY------CICHllgmLSCCLNPILY 262
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
90-399 8.41e-12

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 65.36  E-value: 8.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLL-VLYLMKSMQgwRKSSINLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSMVTSMNMY 167
Cdd:cd15210   9 VFMVVGVPGNLLtVLALLRSKK--LRTRTNAFIINLSISDLLFcAFNLPL-AASTFLHQAWIHGETLCRVFPLLRYGLVA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 168 ASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgrslgdsccFSAKALCVWI---WALAALASLPSAIFSTTVKVMGE 244
Cdd:cd15210  86 VSLLTLVLITLNRYILIAHPSLYPRI------------------YTRRGLALMIagtWIFSFGSFLPLWLGIWGRFGLDP 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 245 ELCLVRFPDKLLGRDRQFWLglyhsqkVLLGFVLPLGIIILCYLLlvrfiadrraagtkggaavaggrptgasaRRLSKV 324
Cdd:cd15210 148 KVCSCSILRDKKGRSPKTFL-------FVFGFVLPCLVIIICYAR-----------------------------REDRRL 191
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455271 325 TKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPfsqeyflcqvYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15210 192 TRMMLVIFLCFLVCYLP---ITLVNVFDDEVAPP----------VLHIIAYVLIWLSSCINPIIYVAMNRQYRQA 253
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
80-397 9.79e-12

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 65.70  E-value: 9.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  80 VRILISVVYWVVCALGLAGNLLVLYLMKSMqgwrKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVS 159
Cdd:cd15977   2 VNTILSCVIFLVGIIGNSTLLRIIYKNKCM----RNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASAlksHRTRGHGrgdccgrslgdSCCFSAKALCVwIWALAALASLPSAIFSTTV 239
Cdd:cd15977  78 FIQKASVGITVLSLCALSIDRYRAVASW---SRIRGIG-----------IPVWKAVEVTL-IWAVAIIVAVPEAIAFDMV 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KV--MGEELCLVRFPDKllgrDRQFWLGLYHSQKV--LLG--FVLPLGIIILCYLLLVRFIADRraagtKGGAAVAggrp 313
Cdd:cd15977 143 EIdyRGQTLLVCMLPME----QTSSFMRFYQDVKDwwLFGfyFCLPLACTGVFYTLMSCEMLSI-----KNGMRIA---- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 314 TGASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVpfSQEYFLCQVYAFP-----VSVCLAHSNSCLNPVL 388
Cdd:cd15977 210 LNDHMKQRREVAKTVFCLVVIFALCWLP---LHLSRILKKTIYD--VKDPQRCELLSFLlvmdyTGINMASLNSCINPVA 284

                ....*....
gi 20455271 389 YCLVRREFR 397
Cdd:cd15977 285 LYFVSRKFK 293
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
98-400 9.85e-12

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 65.33  E-value: 9.85e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  98 GNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAM 176
Cdd:cd15321  23 GNVLVIIAVLTSRSLRAPQ-NLFLVSLAAADILVaTLIIPF-SLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAI 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 177 SVTRYHSVASALKSHRTRGHGRGDCcgrslgdsccfsakaLCVWIWALAALASLPSAIFSTTVKvmGEELCLvrfPDKLL 256
Cdd:cd15321 101 SLDRYWSVSRAIEYNSKRTPRRIKC---------------IILIVWLIAAVISLPPLIYKGKQK--DEQGGL---PQCKL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 257 GRDRqfWLGLYHSqkvLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgasarrlSKVTKSVTIVVLSFF 336
Cdd:cd15321 161 NEEA--WYILSSS---IGSFFAPCLIMILVYLRIYLIAKNRE-----------------------KRFTFVLAVVIGVFV 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455271 337 LCWLP-NQALTTWSILIKFNAVPFSQEYFLcqvyaFPVSVClahsNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15321 213 LCWFPfFFSYSLGAICPELCKVPHSLFQFF-----FWIGYC----NSSLNPVIYTIFNQDFRRAF 268
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
85-397 1.05e-11

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 65.65  E-value: 1.05e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  85 SVVYWVVCALGLAGN---LLVLYLMKSMqgwrKSSINLFVTNLALTDF-QFVLTLPFwAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15976   4 TVVSCLVFVLGIIGNstlLRIIYKNKCM----RNGPNILIASLALGDLlHIIIDIPI-NVYKLLAEDWPFGVEMCKLVPF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASAlksHRTRGHGRGDCCGRSLgdsccfsakalcVWIWALAALASLPSAIF--STT 238
Cdd:cd15976  79 IQKASVGITVLSLCALSIDRYRAVASW---SRIKGIGVPKWTAVEI------------VLIWVVSIILAVPEAIGfdMIT 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEEL--CLVRFPDK-----LLGRDRQFWLGLYHsqkvllgFVLPLGIIILCYLLLVRFIADRraagtKGGAAVAgg 311
Cdd:cd15976 144 MDYKGELLriCLLHPIQKtafmqFYKTAKDWWLFSFY-------FCLPLACTAVFYTLMTCEMLRK-----KNGMQIA-- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 rpTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQE---YFLCQVYafpVSVCLAHSNSCLNPVL 388
Cdd:cd15976 210 --LNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTIYDEKDPNRCEllsFFLVLDY---IGINMASLNSCINPIA 284

                ....*....
gi 20455271 389 YCLVRREFR 397
Cdd:cd15976 285 LYLVSKRFK 293
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
90-399 1.14e-11

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 65.29  E-value: 1.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCAL----GLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMN 165
Cdd:cd15131   5 VTCVLlfvvGVTGNLMTMLVVSKYRDMRTTT-NLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPsaIFsTTVKVMGEE 245
Cdd:cd15131  84 TYSTILNITALSVERYFAICFPLRAKVVVTKRR---------------VKLVILVLWAVSFLSAGP--IF-VLVGVEHEN 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 246 LCLVRFPDKLLGRDRQFWLGLYHSQKVL--LGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVaggrptgaSARRLSK 323
Cdd:cd15131 146 GTNPIDTNECKATEYAVRSGLLTIMVWVssVFFFLPVFCLTVLYSLIGRKLWRRRRENIGPNASH--------RDKNNRQ 217
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20455271 324 VTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15131 218 TVKMLAVVVFAFVLCWLP---FHVGRYLFSKSFEAGSLEIALISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVA 290
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
82-400 2.30e-11

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 64.14  E-value: 2.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQFVLT-LPFWAVENALDFkWPFGKAMCKIVSM 160
Cdd:cd15325   1 IVLGVILGGFILFGVLGNILVI-LSVACHRHLQTVTHYFIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGdccgrslgdsccfSAKALCVWIWALA-ALASL----PSAIF 235
Cdd:cd15325  79 VDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRG-------------LLALLCVWVLSLViSIGPLfgwkEPAPE 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 STTVKVMGEELCLVRFpdkllgrdrqfwlglyhsqKVLLGFVLPLGIIIL----CYLLLVRFIADRRAAGTKGgaavagg 311
Cdd:cd15325 146 DETICQITEEPGYALF-------------------SALGSFYLPLAIILVmycrVYVVALKFSREKKAAKTLG------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 rptgasarrlskvtksvtIVVLSFFLCWLPNqalttwsilikFNAVPFSQEY--FLCQVYAFPVSVCLAHSNSCLNPVLY 389
Cdd:cd15325 200 ------------------IVVGCFVLCWLPF-----------FLVMPIGSIFpaYKPSDTVFKITFWLGYFNSCINPIIY 250
                       330
                ....*....|.
gi 20455271 390 CLVRREFRKAL 400
Cdd:cd15325 251 PCSSQEFKKAF 261
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
82-399 2.32e-11

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 64.43  E-value: 2.32e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15132   1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMR-TTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSH----RTRghgrgdccgrslgdsccfsAKALCVWIWALAALASLPSaIFST 237
Cdd:cd15132  80 SEGCTYATILHITALSIERYLAICFPLRAKvlvtRRR-------------------VKCVIAALWAFALLSAGPF-LFLV 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMgEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLG--FVLPLgiiiLCYLLLVRFIAdRRAAGTKGGAAvagGRPTG 315
Cdd:cd15132 140 GVEQD-NNIHPDDFSRECKHTPYAVSSGLLGIMIWVTTtyFFLPM----LCLSFLYGFIG-RKLWKSKNDLR---GPNAA 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 ASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCqvyafpVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15132 211 ARERSHRQTVRILAVVVLAFIICWLPFHIGRILFANTEDYRTMMFSQYFNI------VAMQLFYLSASINPILYNLISRK 284

                ....
gi 20455271 396 FRKA 399
Cdd:cd15132 285 YRAA 288
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
82-399 2.58e-11

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 63.89  E-value: 2.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVL---YLMKSMQgwrkSSINLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKI 157
Cdd:cd15064   1 VLISVLLSLIILATILGNALVIaaiLLTRKLH----TPANYLIASLAVADLLVaVLVMPLSAVYELTG-RWILGQVLCDI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15064  76 WISLDVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKR---------------AAVMIALVWTLSICISLPPLFGWR 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVrfpdkllgrDRQFWLGLYHSqkvLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrptgaS 317
Cdd:cd15064 141 TPDSEDPSECLI---------SQDIGYTIFST---FGAFYIPLLLMLILYWKIYR------------------------A 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLSKVTKSVTIVVLSFFLCWLPnqalttwsILIKFNAVPFSQEyflCQVYA--FPVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15064 185 AARERKAAKTLGIILGAFIVCWLP--------FFLVALIVPLCSH---CWIPLalKSFFLWLGYFNSLINPLIYTFFNKD 253

                ....
gi 20455271 396 FRKA 399
Cdd:cd15064 254 FRKA 257
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
82-400 3.22e-11

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 63.76  E-value: 3.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLT-LPFWAVENALDFkWPFGKAMCKIVSM 160
Cdd:cd15326   1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPT-NYFIVNLAIADLLLSFTvLPFSATLEILGY-WVFGRIFCDIWAA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsakalcvwiwalAALASLPSAIFSTTVK 240
Cdd:cd15326  79 VDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKR--------------------------AILALLGVWVLSTVIS 132
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VmGEELCLVRFP---DKLLGRDRQFWLGLYHSqkvLLGFVLPLGIIIL----CYLLLVRFIADRRAAGTKGgaavaggrp 313
Cdd:cd15326 133 I-GPLLGWKEPAppdDKVCEITEEPFYALFSS---LGSFYIPLIVILVmycrVYIVALKFSREKKAAKTLG--------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 314 tgasarrlskvtksvtIVVLSFFLCWLPNqalttwsilikFNAVPFSQ--EYFLCQVYAFPVSVCLAHSNSCLNPVLYCL 391
Cdd:cd15326 200 ----------------IVVGMFILCWLPF-----------FIALPLGSlfSHLKPPETLFKIIFWLGYFNSCLNPIIYPC 252

                ....*....
gi 20455271 392 VRREFRKAL 400
Cdd:cd15326 253 SSKEFKRAF 261
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
82-306 3.57e-11

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 63.61  E-value: 3.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVEnALDFKWPFGKAMCKIVSMV 161
Cdd:cd14983   1 QLSLMVYVLTILLGLPSNLLALYAFVNRARLRLTPNVIYMINLCLSDLVFILSLPIKIVE-ALSSAWTLPAVLCPLYNLA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdSCCFSAKAlCVWIWALAAL---------ASLPS 232
Cdd:cd14983  80 HFSTLYASTCFLTAISAGRYLGVAFPIKYQLYK--------------KPLYSCLV-CVAIWALVIFhvtlvfileTSGGT 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 233 AIFSTTVKvmGEELCLVRFPDKLLGrdrqFWLGLYHSQKVLLgFVLPLGIIILCYLLLVRFIA--------DRRAAGTKG 304
Cdd:cd14983 145 LDINTPVG--NSSTCYENFTPEQLA----LLAPVRLELSLVL-FFLPLAITAFCYVRCIRILVrsrlherrKRRAVRVAV 217

                ..
gi 20455271 305 GA 306
Cdd:cd14983 218 ST 219
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
85-397 3.73e-11

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 64.08  E-value: 3.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  85 SVVYWVVCALGLAGN---LLVLYLMKSMqgwrKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPF-----GKAMCK 156
Cdd:cd15128   4 TVVSCLIFIVGIIGNstlLRIIYQNKCM----RNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFgdqpfGQFLCK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 157 IVSMVTSMNMYASVFFLTAMSVTRYHSVASalkshrtrghgrgdcCGRSLGDSCCFSAKALCVWIWALAALASLPSAI-F 235
Cdd:cd15128  80 LVPFIQKASVGITVLNLCALSVDRYRAVAS---------------WSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIgF 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 S-TTVKVMGEEL--CLVRFPDKLLGRDRQF---WL-GLYhsqkvllgFVLPLGIIILCYLLLVRFIADRRAAGTKggaav 308
Cdd:cd15128 145 DmVRFNYKGVTLrtCLLRPETSFMKFYIDVkdwWLfGFY--------FCLPLVCTAIFYTLMTCEMLRKRNGMLR----- 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 309 aggRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVL 388
Cdd:cd15128 212 ---IALNEHLKQRREVAKTVFCLVVIFALCWLPLHLSRILKLTVYDQNDPNRCELLSFLLVLDYFGINLATLNSCINPIA 288

                ....*....
gi 20455271 389 YCLVRREFR 397
Cdd:cd15128 289 LYFVSRKFK 297
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
90-406 3.87e-11

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 63.43  E-value: 3.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMksmqGWR--KSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPfGKAMCKIVSMVTSMNMY 167
Cdd:cd14973   9 LLSLCGLVGNGLVLWLL----GFRikRNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSLP-GFALCRLLATLMFFSYT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 168 ASVFFLTAMSVTRyhsVASALKSHRTRGHgrgdccgRSLGDSCCfsakaLCVWIWALAALASLPSAIFsttvkvmgeelc 247
Cdd:cd14973  84 VGLSLLAAISTER---CLSVLFPIWYRCH-------RPKHLSAV-----VCALLWALSLLLSVLESYF------------ 136
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 248 lvrfPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggrptGASARRLSKVTKS 327
Cdd:cd14973 137 ----CGFLFWKFNESACRTFNFLSALLFLLLFLVMCVSSLTLLIRVQC-------------------SSQRRPPTRLYVV 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 328 VTIVVLSFFLCWLPNQAltTWSILIKFNAVPFsqeyflcqVYAFPVSVCLAHSNSCLNPVLYCLV----RREFRKALKSL 403
Cdd:cd14973 194 ILLTVLVFLLCGLPLGI--YWFLLLWFSNYLF--------HTFHPISDLLSCVNSSANPIIYFFVgslrGRRLREPLRVV 263

                ...
gi 20455271 404 LWR 406
Cdd:cd14973 264 LQR 266
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
82-400 5.85e-11

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 63.27  E-value: 5.85e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVcalglagnLLVLYLMKSMQGW------RKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMC 155
Cdd:cd15969   1 IVFPVLYLII--------FIGSILLNGLAVWiffhirNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLC 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 156 KIVSMVTSMNMYASVFFLTAMSVTRYHSVAsalkshrtrghgrgdccgRSLGDSCCFS---AKALCVWIWALAALASLPS 232
Cdd:cd15969  73 RYTSVLFYASMYTSIVFLGLISLDRYLKVV------------------KPFGDSRMYSitfTKVLSACVWLIMAFLSLPN 134
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 233 AIFsTTVKVMGEEL--CLvrfpdKLLGRDRQFWLGLYHSQKVLLgFVLPLGIIILCYLLLVRFIADrraagtkggaavaG 310
Cdd:cd15969 135 IIL-TNGQPTEDNIhdCS-----KLKSPLGVKWHTAVSYINICI-FVAVLVILIVCYISISRYIYK-------------S 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 311 GRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALT---TWSILIKFNAVPFSQEYFLCQVYAFPVSVClahsNSCLNPV 387
Cdd:cd15969 195 SKQFISSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRipfTFSQLDKILDCTIKTILYYCKEATLFLSAC----NVCLDPI 270
                       330
                ....*....|...
gi 20455271 388 LYCLVRREFRKAL 400
Cdd:cd15969 271 IYFFMCRSFSQRL 283
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
82-399 1.48e-10

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 62.12  E-value: 1.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQ--GWRKSSINLFVTNLALTD-FQFVLTLP---FWAVENAldFKWPFGKAMC 155
Cdd:cd15135   1 ITLTLLYSLILVAGILGNSATIKVTQVLQkkGYLQKSVTDHMVSLACSDlLVLLLGMPvelYSAIWDP--FATPSGNIAC 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 156 KIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccfSAKALCVWIWALAALASLPsAIF 235
Cdd:cd15135  79 KIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGS----------------RVRLLICFVWLTSALVALP-LLF 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 SttvkvMGEELCLVRFPDKLLGRDR------QFWLGLYHSQK-------VLLGFVLPLGII----ILCYLLLVRFIADRR 298
Cdd:cd15135 142 A-----MGTEDPLEAFPSYRGTRHHcqdqksNLTICTSLSSKwtvfqasIFSAFVLYLLVLasvaFMCRRMMRALMGSKK 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 299 A--AGTKGGAAVAGGR----PTGASARRlsKVTKSVTIVVLSFFLCWLPNQALTtwsilIKFNAVPFSQ---EYFLCQVY 369
Cdd:cd15135 217 GavAVKGPGGSVQLLRkhesAEGKTARK--QTILFLGLIVGTLAVCWMPNQIRR-----IMAAAKPKDDwtrSYFRAYII 289
                       330       340       350
                ....*....|....*....|....*....|
gi 20455271 370 AFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15135 290 LLPIADTFFYLSSVLNPLLYNLSSQQFRSV 319
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
82-399 1.66e-10

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 61.79  E-value: 1.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQF-VLTLPFWAVeNALDFKWPFGKAMCKIVSM 160
Cdd:cd15403   1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMR-SAINLLLATLAFSDIMLsLLCMPFTAV-TIITVDWHFGAHFCRISAM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVAS---ALKSHRtrghgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15403  79 LYWFFVLEGVAILLIISVDRFLIIVQrqdKLNPHR---------------------AKVMIAISWVLSFCISFPSVVGWT 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMgeelclVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFI----------ADRRAAGTKGGAA 307
Cdd:cd15403 138 LVEVP------ARAPQCVLGYTESPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVrrnavrihnhADSLCLSQVSKLG 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 308 VAG-GRPTGASARRLSKVTKSVTIVVL--SFFLCWLPNQALTTWSIlikfnavpFSQEYFLCQVYaFPVSVC---LAHSN 381
Cdd:cd15403 212 LMGlQRPHQMNVDMSFKTRAFTTILILfvGFSLCWLPHTVFSLLSV--------FSRRFYYSSSF-YPISTCvlwLSYLK 282
                       330
                ....*....|....*...
gi 20455271 382 SCLNPVLYCLVRREFRKA 399
Cdd:cd15403 283 SVFNPVIYCWRIKKFREA 300
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
80-400 1.84e-10

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 61.42  E-value: 1.84e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  80 VRILIsvvYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVL-TLPFWAVENAL-DFKwpFGKAMCKI 157
Cdd:cd15978   2 VRILL---YSLIFLLSVLGNSLIIAVLIRNKRMRTVT-NIFLLSLAVSDLMLCLfCMPFTLIPNLLkDFI--FGSAVCKT 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSH--RTRGHgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAIF 235
Cdd:cd15978  76 ATYFMGISVSVSTFNLVAISLERYSAICKPLKSRvwQTKSH-----------------ALKVIAATWCLSFTIMLPYPIY 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 STTVKVMGEE-----LCLVRFPDKLLgrdRQFWlglyHSQKVLLGFVLPLGIIILCYLLL-------VRFIADRRaagtk 303
Cdd:cd15978 139 SNLVPFTRINnstgnMCRLLWPNDVT---QQSW----YIFLLLILFLIPGIVMMTAYGLIslelyrgIKFLMAKK----- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 304 ggaavaggrptgasarrlsKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAvpfsqEYFLCQVyafPVSVC--LAHSN 381
Cdd:cd15978 207 -------------------RVIRMLIVIVILFFLCWTPIFSANAWRAFDTRSA-----DRLLSGA---PISFIhlLSYTS 259
                       330
                ....*....|....*....
gi 20455271 382 SCLNPVLYCLVRREFRKAL 400
Cdd:cd15978 260 ACVNPIIYCFMNKRFRMGF 278
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
82-399 2.95e-10

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 60.58  E-value: 2.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLT-LPFWAVENALDFkWPFGKAMCKIVSM 160
Cdd:cd15062   1 IVVGVALGAFILFAIGGNLLVILSVACNRHLR-TPTHYFIVNLAVADLLLSFTvLPFSATLEVLGY-WAFGRIFCDVWAA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLpSAIFSTTVK 240
Cdd:cd15062  79 VDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARR---------------ATVALLIVWVLSLVISI-GPLLGWKEP 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEElclvrfpdKLLGRDRQFWLGLYHSqkvLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrpTGASARR 320
Cdd:cd15062 143 APADE--------QACGVNEEPGYVLFSS---LGSFYLPLAIILVMYCRVYV---------------------VAFKFSR 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNqalttwsilikFNAVPFSQEYFLCQVYAFPVSVC--LAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15062 191 EKKAAKTLGIVVGAFVLCWFPF-----------FVVLPLGSLFSTLKPPEPVFKVVfwLGYFNSCLNPIIYPCSSREFKR 259

                .
gi 20455271 399 A 399
Cdd:cd15062 260 A 260
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
82-399 3.11e-10

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 60.46  E-value: 3.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLT-LPFWAVeNALDFKWPFGKAMCKIVSM 160
Cdd:cd15213   1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMR-SAINLLLANLAFSDIMLSLVcMPFAAV-TIITGRWIFGDIFCRISAM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVA---SALKSHRtrghgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15213  79 LYWFFVLEGVAILLIISVDRYLIIVqrqDKLNPHR---------------------AKILIAVSWVLSFCVSFPPLVGWG 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKV-MGEELCLVRFPDKLLGRdrqfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIadrRAAGTKGgaavaggrptga 316
Cdd:cd15213 138 KYEFpPRAPQCVLGYTESPADR-------IYVVLLLVAVFFIPFLIMLYSYFCILNTV---RSFKTRA------------ 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 sarrlskvTKSVTIVVLSFFLCWLPNqalTTWSILIKFNAvpfsqeyflCQVYAFPVSVC---LAHSNSCLNPVLYCLVR 393
Cdd:cd15213 196 --------FTTILILFIGFSVCWLPY---TVYSLLSVFSR---------YSSSFYVISTCllwLSYLKSAFNPVIYCWRI 255

                ....*.
gi 20455271 394 REFRKA 399
Cdd:cd15213 256 KKFREA 261
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
90-400 4.07e-10

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 60.93  E-value: 4.07e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMKSMQGWRKSSInLFVTNLALTD-FQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYA 168
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPY-YFLLDLCLADgLRSLACFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCFH 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 169 SVFFLTAMSVTRYHSVASAlKSHRTRghgrgdccgrsLGDSCCFsakALCVWIWALAALASLPSAIFSTTVKVMGEElcl 248
Cdd:cd15005  88 SAFTLFCIAVTRYMAIAHH-RFYAKR-----------MTFWTCL---AVICMAWTLSVAMAFPPVFDVGTYTFIREE--- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 249 vrfpDKLLGRDRqfwlglYHSQKVLLGFVLPLGIII----LCYLLLVRFIADRR------------------AAGTKGGA 306
Cdd:cd15005 150 ----DQCTFEHR------SYKANDTLGFMLVLAVVIaathLVYLKLLIFLRHHRkmkpaqlvpaisqnwtfhGPGATGQA 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 307 A---VAG-GRP------------TGASARRL---------SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPfsq 361
Cdd:cd15005 220 AanwTAGfGRGptpptllgirqaFHSGARRLlvldefkmeKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRGYAVP--- 296
                       330       340       350
                ....*....|....*....|....*....|....*....
gi 20455271 362 eyflcQVYaFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15005 297 -----QGF-LTAAVWMTFAQAGVNPIVCFFFNRELRKCL 329
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
82-398 5.39e-10

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 60.63  E-value: 5.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM---KSMQGWrKSSINLFVTNLALTDFQ-FVLTLP------FWavenaLDFKWPFG 151
Cdd:cd15355   1 VLVTAIYLALFVVGTVGNSITLYTLarkKSLQHL-QSTVHYHLASLALSDLLiLLLAMPvelynfIW-----VHHPWAFG 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 152 KAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLP 231
Cdd:cd15355  75 DAACRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSR---------------TKKFISAIWLASALLAIP 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 232 sAIFsttvkVMGEELCLVRFPDKLLGRD--RQFWLGLYHSQKVLLGFVLPLGII-ILCYLLLVRFIADRRAAGTKGGAAV 308
Cdd:cd15355 140 -MLF-----TMGEQNRSGTHPGGLICTPivDTSTLKVVIQVNAFLSFLFPMLVIsVLNTLIANQLTVMVNQAEQENQVCT 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 309 AGGRPTGAS-------ARRLSKVTKSVTIVVLSFFLCWLPNQALTtwsilIKFNAVP---FSQEYFLCQVYAFPVSVCLA 378
Cdd:cd15355 214 IGGQRTVLSvsmepgrVQSLRHGVLVLRAVVIAFVVCWLPYHVRR-----LMFCYVSdeqWTTFLYDFYHYFYMLTNVLF 288
                       330       340
                ....*....|....*....|
gi 20455271 379 HSNSCLNPVLYCLVRREFRK 398
Cdd:cd15355 289 YVSSAINPILYNLVSANFRQ 308
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
90-395 5.85e-10

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 59.95  E-value: 5.85e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLY-LMKSMQGWRKSSINLFVTNLALTDF-QFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMY 167
Cdd:cd14981   9 LMFVFGVLGNLLALIvLARSSKSHKWSVFYRLVAGLAITDLlGILLTSPVVLAVYASNFEWDGGQPLCDYFGFMMSFFGL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 168 ASVFFLTAMSVTRYHSVASALkSHRTRGHGRGdccgrslgdsccfsAKALCVWIWALAAL-ASLPSAIFSTTVKVMGEEL 246
Cdd:cd14981  89 SSLLIVCAMAVERFLAITHPF-FYNSHVKKRR--------------ARLMLGAVWAFALLiASLPLLGLGSYVLQYPGTW 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 CLVRFPDKLLGrdRQFWLGLYHSqkvlLGFVLpLGIIILCYLLLVRFIADRRAagtkggaavagGRPTGASARRLSKVTK 326
Cdd:cd14981 154 CFLDFYSKNTG--DAAYAYLYSI----LGLLI-LLVTLLCNLLVIITLLRMRR-----------RKKRHRRSRRSARRQK 215
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 327 SVTI--------VVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYFLcqvyafpVSVCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd14981 216 RNEIqmvvlllaITVVFSVCWLP---LMIRVLINATGDSEKNGKTDL-------LAVRMASWNQILDPWVYILLRKE 282
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
90-399 6.17e-10

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 60.16  E-value: 6.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWAvENALDFKWPFGKAMCKIVSMVTSMNMYA 168
Cdd:cd15058   9 LIILAIVVGNLLVIIAIARTSRLQTMT-NIFITSLACADLVMgLLVVPLGA-TIVVTGKWQLGNFWCELWTSVDVLCVTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 169 SVFFLTAMSVTRYHSVASALKShrtrghgrgdccgRSLGDSCCfsAKALCVWIWALAALAS-LP------SAIFSTTVKV 241
Cdd:cd15058  87 SIETLCVIAVDRYIAITRPLRY-------------QVLLTKRR--ARVIVCVVWIVSALVSfVPimnqwwRANDPEANDC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKllgrdrqfwlgLYHSQKVLLGFVLPLGIIILCYLLL-------VRFIADRR----------AAGTKG 304
Cdd:cd15058 152 YQDPTCCDFRTNM-----------AYAIASSVVSFYIPLLIMIFVYARVfliatrqLQLIDKRRlrfqsecpapQTTSPE 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 305 GAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYFLcqvyafpVSVCLAHSNSCL 384
Cdd:cd15058 221 GKRSSGRRPSRLTVVKEHKALKTLGIIMGTFTLCWLP---FFIANIINVFNRNLPPGEVFL-------LLNWLGYINSGL 290
                       330
                ....*....|....*
gi 20455271 385 NPVLYCLvRREFRKA 399
Cdd:cd15058 291 NPIIYCR-SPEFRTA 304
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
94-400 7.66e-10

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 59.75  E-value: 7.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  94 LGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQF-VLTLPFWAVeNALDFKWPFGKAMCKIVSMvtsMNMY---AS 169
Cdd:cd15073  13 ISTISNGIVLVTFVKFRELR-TPTNALIINLAVTDLGVsIIGYPFSAA-SDLHGSWKFGYAGCQWYAF---LNIFfgmAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 170 VFFLTAMSVTRYHSVasalkshrtrghgrgdcCGRSLGDSCCFS---AKALCVWIWAL--AALASLPSAIFSTTVKVMge 244
Cdd:cd15073  88 IGLLTVVAVDRYLTI-----------------CRPDLGRKMTTNtytVMILLAWTNAFfwAAMPLVGWASYALDPTGA-- 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 245 eLCLVRFPDKllgrDRQFwlGLYHSQKVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaAVAGGRPTGASARRLS-- 322
Cdd:cd15073 149 -TCTINWRKN----DSSF--VSYTMSVIVVNFIVPLAVMFYCYYNVSRFVK-----------KVLASDCLESVNIDWTdq 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 323 -KVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYflcqvyafpVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15073 211 nDVTKMSVIMIVMFLVAWSPYSIVCLWASFGEPKKIPPWMAI---------IPPLFAKSSTFYNPCIYVIANKKFRRAI 280
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
82-398 1.11e-09

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 59.15  E-value: 1.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFqFVLTLPFWAVENA-LDFKWPFGKAMCKIVSM 160
Cdd:cd15401   1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAG-NIFVVSLSVADL-VVAVYPYPLILLAiFHNGWTLGNIHCQISGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgRSLGDSCCFsakaLCVwIWALAALASLPS-------- 232
Cdd:cd15401  79 LMGLSVIGSVFNITAIAINRYCYICHSLRYDKL----------YNMKKTCCY----VCL-TWVLTLAAIVPNffvgslqy 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 233 --AIFSTTVKvmgeelclvrfpdkllgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYL---LLVRFIADRRAAGTKggaa 307
Cdd:cd15401 144 dpRIYSCTFA--------------------QTVSSSYTITVVVVHFIVPLSIVTFCYLriwVLVIQVKHRVRQDSK---- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 308 vagGRPTGASARRLskvtKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFlcqvyaFPVSVCLAHSNSCLNPV 387
Cdd:cd15401 200 ---QKLKANDIRNF----LTMFVVFVLFAVCWGPLNFIGLAVAINPLKVAPKIPEWL------FVLSYFMAYFNSCLNAV 266
                       330
                ....*....|.
gi 20455271 388 LYCLVRREFRK 398
Cdd:cd15401 267 IYGVLNQNFRK 277
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
84-400 1.32e-09

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 58.77  E-value: 1.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQFVLT-LPFWAVENALDFkWPFGKAMCKIVSMVT 162
Cdd:cd15327   3 VGVFLAIFILMAIVGNILVI-LSVACNRHLQTVTNYFIVNLAIADLLLSTTvLPFSATLEVLGF-WAFGRVFCDIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVM 242
Cdd:cd15327  81 VLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERK---------------AGVILVLLWVSSMVISIGPLLGWKEPPPP 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 GEELCLVrfpdkllgrDRQFWLGLYHSqkvLLGFVLPLGIIIL----CYLLLVRFIADRRAAgtkggaavaggrptgasa 318
Cdd:cd15327 146 DESICSI---------TEEPGYALFSS---LFSFYLPLMVILVmyfrVYVVALKFSREKKAA------------------ 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 rrlskvtKSVTIVVLSFFLCWLPNqalttwsilikFNAVPFSQeyFLCQV----YAFPVSVCLAHSNSCLNPVLYCLVRR 394
Cdd:cd15327 196 -------KTLAIVVGVFILCWFPF-----------FFVLPLGS--FFPALkpseMVFKVIFWLGYFNSCVNPIIYPCSSK 255

                ....*.
gi 20455271 395 EFRKAL 400
Cdd:cd15327 256 EFKRAF 261
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
86-400 1.40e-09

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 59.10  E-value: 1.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLA----GNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15318   1 LVIYLACAIGMLiivlGNLFVVVTVSHFKALH-TPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTrghgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTTvKV 241
Cdd:cd15318  80 DTLFCLTSIFHLCFISIDRHCAICDPLLYPSK------------------FTIRVACIFIAAGWLVPTVYTSVFLYT-KA 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLgFVLPLGIIILCYLLLVrFIADRRAAGTKGGAAVAGGrptgaSARRL 321
Cdd:cd15318 141 VEEGLAELLTSVPCVGSCQLLYNKLWGWLNFPV-FFIPCLIMIGLYVKIF-IVAKRQARAIASLLSDTNG-----ASKRE 213
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFsqeyflcqvyAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15318 214 RKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLNFITPPL----------LFDIIIWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
80-397 1.58e-09

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 59.10  E-value: 1.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  80 VRILISVVYWVVCALGLAGNLLVLYLMKSMqgwrKSSINLFVTNLALTDFQF-VLTLPFwAVENALDFKWPF-----GKA 153
Cdd:cd15975   2 INTVLSCIIFIVGMVGNATLLRIIYQNKCM----RNGPNALIASLALGDLIYiVIDIPI-NVYKLLAQKWPFddssfGVF 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 154 MCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASalkshrtrghgrgdcCGRSLGDSCCFSAKALCVWIWALAALASLPSA 233
Cdd:cd15975  77 LCKLVPFLQKASVGITVLNLCALSVDRYRAVAS---------------WSRVQGIGIPLITAIEIFSIWVLSFILAIPEA 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 234 IFSTTV--KVMGEEL--CLVRFPDKLLG---RDRQFWL-GLYhsqkvllgFVLPLGIIILCYLLLVRFIADRRaagtKGG 305
Cdd:cd15975 142 IGFVMVpfEYNGEQYrtCMLNATTKFMNfyvDAKDWWLfGFY--------FCVPLACTAIFYTLMTCEMLNRR----KGS 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 306 AAVAggrpTGASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYflCQVYAFP-----VSVCLAHS 380
Cdd:cd15975 210 LRIA----LSEHLKQRREVAKTVFCLVVIFALCWFP---LHLSRILKKTVYNENDPRR--CELLSFLlvmdyISINLATM 280
                       330
                ....*....|....*..
gi 20455271 381 NSCLNPVLYCLVRREFR 397
Cdd:cd15975 281 NSCINPIALYFVSKKFK 297
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
84-398 1.71e-09

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 58.71  E-value: 1.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFqFVLTLPFWAVENALDFK-WPFGKAMCKIVSMVT 162
Cdd:cd15400   3 LSSVLIFTTVVDILGNLLVIISVFRNRKLRNSG-NVFVVSLALADL-VVALYPYPLVLVAIFHNgWALGEMHCKVSGFVM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdscCFSAKALCVWIWALAALASLP----------S 232
Cdd:cd15400  81 GLSVIGSIFNITGIAINRYCYICHSFAYDKLYS---------------RWNTLLYVCLIWALTVVAIVPnffvgsleydP 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 233 AIFSTTVKvmgeelclvrfpdkllgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYL-LLVRFIADRRAAGTKggaavagG 311
Cdd:cd15400 146 RIYSCTFV--------------------QTASSSYTIAVVVIHFIVPITVVSFCYLrIWVLVIQVRRKVKSE-------S 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 RPTGASARRLSKVTKSVTIVVLSFflCWLPNQALTTwsilikfnAVPFSQEYFLCQV--YAFPVSVCLAHSNSCLNPVLY 389
Cdd:cd15400 199 KPRLKPSDFRNFLTMFVVFVIFAI--CWAPLNLIGL--------AVAINPQEMAPKVpeWLFVVSYFMAYFNSCLNAIIY 268

                ....*....
gi 20455271 390 CLVRREFRK 398
Cdd:cd15400 269 GLLNQNFRK 277
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
82-399 1.72e-09

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 58.28  E-value: 1.72e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQF-VLTLPFWAVENALDFkWPFGKAMCKIVSM 160
Cdd:cd15063   1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLR-TVTNLFIVSLACADLLVgTLVLPFSAVNEVLDV-WIFGHTWCQIWLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKShrtrghgrgdccgRSLGDSccFSAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15063  79 VDVWMCTASILNLCAISLDRYLAITRPIRY-------------PSLMST--KRAKCLIAGVWVLSFVICFPPLVGWNDGK 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 vmgEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrptgaSARR 320
Cdd:cd15063 144 ---DGIMDYSGSSSLPCTCELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYR------------------------AARM 196
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPnqalttwsILIKFNAVPFSQEYFLCQVyaFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15063 197 ETKAAKTVAIIVGCFIFCWLP--------FFTVYLVRAFCEDCIPPLL--FSVFFWLGYCNSALNPCIYALFSRDFRFA 265
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
96-400 2.41e-09

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 58.02  E-value: 2.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  96 LAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLT 174
Cdd:cd15323  15 IVGNVLVVIAVLTSRALRAPQ-NLFLVSLASADILVaTLVMPF-SLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 175 AMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIfSTTVKVMGEelclvRFPDK 254
Cdd:cd15323  93 AISLDRYWSVTQAVEYNLKRTPRR---------------VKAIIVTVWLISAVISFPPLI-SMYRDPEGD-----VYPQC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 255 LLGRDRqfWLGLYHSqkvLLGFVLPLGIIILCYLLLVRFiadrraagtkggaavaggrptgASARRlSKVTKSVTIVVLS 334
Cdd:cd15323 152 KLNDET--WYILSSC---IGSFFAPCLIMILVYIRIYRV----------------------AKARE-KRFTFVLAVVMGV 203
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 335 FFLCWLP-NQALTTWSILIKFNAVPFSQEYFLcqvyaFPVSVClahsNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15323 204 FVVCWFPfFFSYSLYGICREACEVPEPLFKFF-----FWIGYC----NSSLNPVIYTIFNQDFRRSF 261
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
79-389 2.43e-09

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 58.25  E-value: 2.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  79 RVRILISVVYWVVCALGLAGNLLVLYlmksMQGWRKSSINLFVTNLALTD-----FQfVLTLPFWAVENAldFKWPfgKA 153
Cdd:cd15388   1 QVEIAVLAIIFACALLSNSLVLLVLW----RRRKQLARMHVFMLHLCIADlvvafFQ-VLPQLVWDITDR--FRGP--DV 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 154 MCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRtrgHGRGDCCGrslgdSCCFSakalcvwiWALAALASLPSA 233
Cdd:cd15388  72 LCRLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQ---KGRARWNG-----PVCVA--------WAISLILSLPQV 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 234 -IFSTTVKVMGEELCLVRFPDKLLGRDRQFWLglyhsqkVLLGFVLPLGIIILCYLLLVRFIADRRAAGT-KGGAAVAGG 311
Cdd:cd15388 136 fIFSKVEVAPGVYECWACFIEPWGLKAYVTWI-------TLVVFVLPTLIITVCQVLIFKEIHINIYLKSqIIVAVVKKK 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 RPTGASARRLSKVTKSVT-------IVVLSFFLCWLPNQALTTWSILikFNAVPfsqeyflCQVYAFPVSVCLAHSNSCL 384
Cdd:cd15388 209 QLLSSRASSVAEVSKAMIktvkmtlVIVLVYVLCWAPFFLVQLWSVW--DPKAP-------TEGATFTILMLLASLNSCT 279

                ....*
gi 20455271 385 NPVLY 389
Cdd:cd15388 280 NPWIY 284
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
92-400 4.37e-09

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 57.29  E-value: 4.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  92 CALGLA---GNLLVLYLMKSMQGWrKSSINLFVTNLALTDFQFV-LTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMY 167
Cdd:cd15310   8 CALILAivfGNVLVCMAVLRERAL-QTTTNYLVVSLAVADLLVAtLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 168 ASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdSCCFSAKALCVWIWALAALASLPSAI-FSTTVKvmgEEL 246
Cdd:cd15310  87 ASILNLCAISIDRYTAVVMPVHYQHGTGQ------------SSCRRVSLMITAVWVLAFAVSCPLLFgFNTTGD---PTV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 CLVRFPDKLLgrdrqfwlglYHSqkvLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgasarrlsKVTK 326
Cdd:cd15310 152 CSISNPDFVI----------YSS---VVSFYLPFGVTLLVYVRIYVVLLREK------------------------KATQ 194
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20455271 327 SVTIVVLSFFLCWLPNQALTTWSILIKFNAVPfsqeyflCQVYAfpVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15310 195 MLAIVLGAFIVCWLPFFLTHILNTHCQACHVP-------PELYS--ATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
90-404 4.43e-09

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 57.22  E-value: 4.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQF-VLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYA 168
Cdd:cd15305   9 IIIILTIGGNILVI-MAVSLEKKLQNATNFFLMSLAVADMLVgILVMPVSLIAILYDYAWPLPRYLCPIWISLDVLFSTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 169 SVFFLTAMSVTRYHSVASALKshrtrgHGRGDCCGRSLgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVMGEELCL 248
Cdd:cd15305  88 SIMHLCAISLDRYVAIRNPIE------HSRFNSRTKAM-------MKIAAVWTISIGISMPIPVIGLQDDEKVFVNGTCV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 249 VRFPDKLLgrdrqfwLGLYhsqkvlLGFVLPLGIIILCYLLLVRFIADRRAAGTKggaavaggrptgasaRRLSKVtksV 328
Cdd:cd15305 155 LNDENFVL-------IGSF------VAFFIPLIIMVITYCLTIQVLQRQQAINNE---------------RRASKV---L 203
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20455271 329 TIVVLSFFLCWLPNQALTTWSILIKFNAvpfsQEYFLCQVyaFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLL 404
Cdd:cd15305 204 GIVFFLFLIMWCPFFITNILSVLCKEAC----DQKLMEEL--LNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYI 273
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
96-398 4.55e-09

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 57.22  E-value: 4.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  96 LAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFqFVLTLPFWAVENALDFK-WPFGKAMCKIVSMVTSMNMYASVFFLT 174
Cdd:cd15402  15 ILGNLLVILSVYRNKKLRNAG-NIFVVSLAVADL-VVAIYPYPLVLTSIFHNgWNLGYLHCQISGFLMGLSVIGSIFNIT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 175 AMSVTRYHSVASALKSHRTrghgrgdccgRSLGDSCCFsakalCVWIWALAALASLPSAIFSTtvkvmgeelcLVRFPDK 254
Cdd:cd15402  93 GIAINRYCYICHSLKYDKL----------YSDKNSLCY-----VLLIWVLTVAAIVPNLFVGS----------LQYDPRI 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 255 LLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYL-LLVRFIADRRAAgtkggaavaggRPTGASARRLSKVTKSVT--IV 331
Cdd:cd15402 148 YSCTFAQSVSSAYTIAVVFFHFILPIIIVTFCYLrIWILVIQVRRRV-----------KPDNKPKLKPHDFRNFVTmfVV 216
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 332 VLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFlcqvyaFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15402 217 FVLFAVCWAPLNFIGLAVAVDPETIVPRIPEWL------FVASYYMAYFNSCLNAIIYGLLNQNFRR 277
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
90-391 8.96e-09

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 56.75  E-value: 8.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTD-----FQfVLTLPFWAVEnaldFKWPFGKAMCKIVSMVTSM 164
Cdd:cd15387   9 LILFLALTGNICVLLAIHTTRH-KHSRMYFFMKHLSIADlvvavFQ-VLPQLIWDIT----FRFYGPDFLCRLVKYLQVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALKSHrtrgHGRGDCCgrslgdsccfsakaLCVWIWALAALASLPS-AIFSTTVKVMG 243
Cdd:cd15387  83 GMFASTYMLLLMSIDRCLAICQPLRSL----HRRSDRV--------------YVLFSWLLSLVFSIPQvHIFSLREVGNG 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 EELCLVRFPdkllgrdrQFW-LGLYHSQKVLLGFVLPLGIIILCYLLLVRFIAD----RRAAGTKGGAAVAGGRptGASA 318
Cdd:cd15387 145 VYDCWADFI--------QPWgPKAYITWITLSVYIIPVLILSVCYGLISFKIWQnvklKTRRETKTPLSSAASG--GAAL 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLSKV----------TKSVTIVVLSFFLCWLPNQALTTWSIlikFNAVPfSQEYFlcqvyAFPVSVCLAHSNSCLNPVL 388
Cdd:cd15387 215 ARVSSVkliskakirtVKMTFVIVLAYIVCWTPFFFVQMWSV---WDPNA-PKEAS-----PFIIAMLLASLNSCCNPWI 285

                ...
gi 20455271 389 YCL 391
Cdd:cd15387 286 YMF 288
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
88-404 1.29e-08

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 56.11  E-value: 1.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  88 YWVVCAL-----GLAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKIVSMV 161
Cdd:cd15307   2 YWALLALvlvlgTAAGNILVC-LAIAWERRLQNVTNYFLMSLAITDLMVaVLVMPLGILTLVKG-HFPLSSEHCLTWICL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTT--V 239
Cdd:cd15307  80 DVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRR---------------VTLKIVFVWLLSIAMSLPLSLMYSKdhA 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 KVMGEELCLVRFPdkllgrdrqfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAgtkggaavaggrpTGASAR 319
Cdd:cd15307 145 SVLVNGTCQIPDP-------------VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSR-------------HGRIIR 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPNQALttwSILIKFNAVPFSQeyflCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15307 199 LEQKATKVLGVVFFTFVILWSPFFVL---NLLPTVCAECEER----ISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQA 271

                ....*
gi 20455271 400 LKSLL 404
Cdd:cd15307 272 FKKVL 276
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
86-398 1.34e-08

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 55.68  E-value: 1.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMksMQGWRKSSINLF-VTNLALTDFQFVLTLPFWAVENAL---DF-----KWPFGkAMCK 156
Cdd:cd15136   5 IGVWFVFLLALVGNIIVLLVL--LTSRTKLTVPRFlMCNLAFADFCMGIYLGLLAIVDAKtlgEYynyaiDWQTG-AGCK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 157 IVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRT---RGHGRGDCCGrslgdsccfsakalcvWIWALaALASLPSA 233
Cdd:cd15136  82 TAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRlslRQAAIIMLGG----------------WIFAL-IMALLPLV 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 234 IFSTTVKVmgeELCLVRFPDKLLGRdrqfwlgLYhsQKVLLGF-VLPLGIIILCYLLLVRFIadrraagtkggaavagGR 312
Cdd:cd15136 145 GVSSYSKT---SICLPFETETPVSK-------AY--VIFLLLFnGLAFLIICGCYIKIYLSV----------------RG 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 313 PTGASARRLSKVTKSVTIVVLSFFLCWLPnQALTTWSILIKFNAVPFSQEYFLCqVYAFPVsvclahsNSCLNPVLYCLV 392
Cdd:cd15136 197 SGRAANSNDTRIAKRMALLVFTDFLCWAP-IAFFGLTAAFGLPLISVSNAKILL-VFFYPL-------NSCANPFLYAIF 267

                ....*.
gi 20455271 393 RREFRK 398
Cdd:cd15136 268 TKQFRR 273
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
90-400 1.44e-08

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 55.71  E-value: 1.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQF-VLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYA 168
Cdd:cd15304   9 IVIILTIAGNILVI-MAVSLEKKLQNATNYFLMSLAIADMLLgFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 169 SVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIF--STTVKVMGEEL 246
Cdd:cd15304  88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTK---------------AFLKIIAVWTISVGISMPIPVFglQDDSKVFKEGS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 CLVrfpdkllgRDRQFwlglyhsqkVLLG----FVLPLGIIILCYLLLVRFIADrraagtkggaavaggrptgaSARRLS 322
Cdd:cd15304 153 CLL--------ADENF---------VLIGsfvaFFIPLTIMVITYFLTIKSLQQ--------------------SISNEQ 195
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 323 KVTKSVTIVVLSFFLCWLPNQALTTWSILIKfnavPFSQEYFLCQVyaFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15304 196 KASKVLGIVFFLFVVMWCPFFITNVMAVICK----ESCNEVVIGGL--LNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
96-400 1.68e-08

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 56.12  E-value: 1.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  96 LAGNLLVLYLMKSMQGWRKSSINLFVTNLALTD-FQFVLTLPFWAVENALDFkWPFGkAMCKIVSMVTSMNMYASVFFLT 174
Cdd:cd15319  15 LLGNILVCAAVVRFRHLRSKVTNIFIVSLAVSDlFVALLVMPWKAVAEVAGY-WPFG-AFCDVWVAFDIMCSTASILNLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 175 AMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFS-----TTVKVMGEELCLV 249
Cdd:cd15319  93 VISVDRYWAISSPFRYERKMTQR---------------VALVMISVAWTLSVLISFIPVQLNwhkdsGDDWVGLHNSSIS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 250 RFP----DKLLGRDrqfwlglYHSQKVLLGFVLPLGIIILCYLLLVRF--IADRRAAGTKGGAAVAGGRPTG-------- 315
Cdd:cd15319 158 RQVeencDSSLNRT-------YAISSSLISFYIPVAIMIVTYTRIYRIaqIQIRRISSLERAAEHAQSCRSNridchhht 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 ---ASARRLSKVTKSVTIVVLSFFLCWLPNQALttwSILIKFNAVPFS--QEYFLC-QVYAFPVSVCLAHSNSCLNPVLY 389
Cdd:cd15319 231 slrTSIKKETKVLKTLSVIMGVFVCCWLPFFIL---NCMVPFCDRPPAdpDAGLPCvSETTFDVFVWFGWANSSLNPIIY 307
                       330
                ....*....|.
gi 20455271 390 CLvRREFRKAL 400
Cdd:cd15319 308 AF-NADFRKVF 317
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
114-400 1.76e-08

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 55.62  E-value: 1.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 114 KSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKShrt 193
Cdd:cd15149  31 NKSFIVYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHT--- 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 194 rghgrgdccgrSLGDSCCFSaKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRFPDKllgrdrqfwLGLYHSQKVL 273
Cdd:cd15149 108 -----------SFVQNVGYS-KALSVVVWMLMAVLSVPNIILTNQSFHEANYTKCARLKSE---------LGIQWHKASN 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 274 LGFVlplGIIILCYLLLVRFIAdrrAAGTKGGAAVAGGRPTGASARRlsKVTKSVTIVVLSFFLCWLPNQALTTWSILIK 353
Cdd:cd15149 167 YICV---SIFWVVFLLLIIFYV---AISRKIYKSNQKFRRNSTNMKA--KSSRNIFSILFVFFVCFVPYHALRIPYTLSQ 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 20455271 354 FNAvpfsqeYFLCQ-----VYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15149 239 TGA------DYSCQsktilYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
82-399 1.98e-08

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 55.13  E-value: 1.98e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15060   1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQ-NFFIVSLAVADLAVaIFVLPL-NVAYFLLGKWLFGIHLCQMWLT 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsCCFSakalCVWIWALAALASLPSAI--FSTT 238
Cdd:cd15060  79 CDILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKR-----------VLLM----IVVVWALSALISVPPLIgwNDWP 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEELCLvrfpdklLGRDRQFWLglYHSqkvLLGFVLPLGIIILCYLLLVRFIA-DRRAAGTKGgaavaggrptgas 317
Cdd:cd15060 144 ENFTETTPCT-------LTEEKGYVI--YSS---SGSFFIPLLIMTIVYVKIFIATSkERRAARTLG------------- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 arrlskvtksvtIVVLSFFLCWLPnqalttwsILIKFNAVPFSQEyflCQVYAFPVS--VCLAHSNSCLNPVLYCLVRRE 395
Cdd:cd15060 199 ------------IIMGVFVVCWLP--------FFLMYVILPFCET---CSPSAKVVNfiTWLGYVNSALNPVIYTIFNLD 255

                ....
gi 20455271 396 FRKA 399
Cdd:cd15060 256 FRRA 259
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
90-400 2.29e-08

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 55.34  E-value: 2.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFgkAMCKIVSMVTSMNMYA 168
Cdd:cd14968   9 LIAVLSVLGNVLVIWAVKLNRALRTVT-NYFIVSLAVADILVgALAIPL-AILISLGLPTNF--HGCLFMACLVLVLTQS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 169 SVFFLTAMSVTRYHSVASAL--KSHRTRGHGRGdccgrslgdsccfsAKALCvwiWALAALASL-PSA---IFSTTVKVM 242
Cdd:cd14968  85 SIFSLLAIAIDRYLAIKIPLryKSLVTGRRAWG--------------AIAVC---WVLSFLVGLtPMFgwnNGAPLESGC 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 GEEL--CLVR--FPDKLLgrdrqfwlgLYHSqkvLLGFVL-PLGIIILCYLLLVRFIadRRAagTKGGAAVAGGRPTGAS 317
Cdd:cd14968 148 GEGGiqCLFEevIPMDYM---------VYFN---FFACVLvPLLIMLVIYLRIFRVI--RKQ--LRQIESLLRSRRSRST 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPfsqeyflcqVYAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd14968 212 LQKEVKAAKSLAIILFLFALCWLPLHIINCITLFCPECKVP---------KILTYIAILLSHANSAVNPIVYAYRIRKFR 282

                ...
gi 20455271 398 KAL 400
Cdd:cd14968 283 QTF 285
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
84-400 3.25e-08

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 54.91  E-value: 3.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGWrKSSINLFVTNLALTDFQF-VLTLPFWAVEnALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15958   3 MSLLMALIVLLIVAGNVLVIVAIGRTQRL-QTLTNLFITSLACADLVMgLLVVPFGATL-VVRGRWLYGSFFCELWTSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVM 242
Cdd:cd15958  81 VLCVTASIETLCVIAIDRYLAITSPFRYQSLLTRAR---------------AKGIVCTVWAISALVSFLPIMMHWWRDED 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 243 GEELCLVRFP---DKLLGRdrqfwlgLYHSQKVLLGFVLPLGIIILCYLLLVRFI---------ADRRAAGTKGGAAVAG 310
Cdd:cd15958 146 DQALKCYEDPgccDFVTNR-------AYAIASSIISFYIPLLIMIFVYLRVYREAkkqikkidkCEGRFHNTLTGLGRKC 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 311 GR-PTGASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYFLCQVYafpvsvcLAHSNSCLNPVLY 389
Cdd:cd15958 219 KRrPSRILALREQKALKTLGIIMGVFTLCWLP---FFLVNVVNVFNRELVPDWLFVFFNW-------LGYANSAFNPIIY 288
                       330
                ....*....|.
gi 20455271 390 CLvRREFRKAL 400
Cdd:cd15958 289 CR-SPDFRKAF 298
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
88-397 4.34e-08

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 54.38  E-value: 4.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  88 YWVVCALGLAGNLLVLYLMKSMQGWRKSsINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMY 167
Cdd:cd15167   7 YYLIFLIGFIGSCFALWAFIQKRSSRKC-INIYLINLLTADFLLTLALPVKIAVDLGIAPWKLKIFHCQVTACLIYINMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 168 ASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVKVMGEELC 247
Cdd:cd15167  86 LSIIFLGFVSIDRYLQLTHSSKLYRIQEPG---------------FAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVG 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 248 LVRFPDKlLGRDrqfWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTkggaavaggrptgasaRRLSKVTKS 327
Cdd:cd15167 151 CADFKTE-FGRH---WHVLTNFICMAIFLNFSAIILISNFLVIRKLYRNKDSEEY----------------RNARQALVN 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20455271 328 VTIVVLSFFLCWLPNQALTTWSILIKFNAV---PFSQEYFLcqvyAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15167 211 ILLVTAGYVICFVPYHIVRIPYTLSQSEVItdcSLKRSLFL----AKESTLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
148-400 5.66e-08

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 54.17  E-value: 5.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 148 WPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRtrghgrgdccgrslgdscCFSAKALCVWI---WAL 224
Cdd:cd15314  66 WYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQPLLYRS------------------KITVRVVLVMIlisWSV 127
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 225 aalaslpSAIFSTTVKVMGEELCLVRFPDKL-LGRDRQFWLGLYHSQKVLLGFVLPlGIIILCYLLLVRFIADRRAAGTK 303
Cdd:cd15314 128 -------SALVGFGIIFLELNIKGIYYNHVAcEGGCLVFFSKVSSVVGSVFSFYIP-AVIMLCIYLKIFLVAQRQARSIQ 199
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 304 GGAAvaggRPTGASARRLSKVTKSVTIVVLSFFLCWLPnqalttwsilikfnavpfsqeYFLCQV------YAFPVSV-- 375
Cdd:cd15314 200 SART----KSGASSSKMERKATKTLAIVMGVFLLCWTP---------------------FFLCNIidpfinYSIPPVLie 254
                       250       260
                ....*....|....*....|....*...
gi 20455271 376 ---CLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15314 255 vlnWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
90-400 5.78e-08

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 53.79  E-value: 5.78e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLA------GNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSMVT 162
Cdd:cd15322   3 LIILVGLLmlltvfGNVLVIIAVFTSRALKAPQ-NLFLVSLASADILVaTLVIPF-SLANEVMGYWYFGKVWCEIYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 163 SMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAI-FSTTVKV 241
Cdd:cd15322  81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRR---------------IKCIIFIVWVISAVISFPPLItIEKKSGQ 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLVrfpdkllgrDRQFWLGLYHSqkvLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgasarrl 321
Cdd:cd15322 146 PEGPICKI---------NDEKWYIISSC---IGSFFAPCLIMVLVYIRIYQIAKNRE----------------------- 190
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 322 SKVTKSVTIVVLSFFLCWLPnqalttwsILIKFNAVPFSQEYFLCQVYAFpvSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15322 191 KRFTFVLAVVIGVFVICWFP--------FFFTYTLTAVCDCSVPETLFKF--FFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
98-404 9.07e-08

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 53.29  E-value: 9.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  98 GNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFqFV--LTLPFWaVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTA 175
Cdd:cd15295  17 GNALVIIAFVVDKNLRHRS-NYFFLNLAISDF-FVgaISIPLY-IPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 176 MSVTRYHSVASALkSHRTRghgrgdccgrslgDSCCFSAKALCVWIWALAALASLPSAIFSTTVKVMGEElCLVRFpdkl 255
Cdd:cd15295  94 ISYDRYQSVSNAV-SYRNQ-------------QTATLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGE-CEPEF---- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 256 lgrdrqFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRraagtkggaavaggrptgasaRRLSKVTKSVTIVVLSF 335
Cdd:cd15295 155 ------FSNWYILAITSVLEFLVPVILVAYFNTQIYWSLWKR---------------------LRDRKLAKSLAIILGTF 207
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 336 FLCWLPNQALTTwsILIKFNAVPFSQEYflcqVYAFpvsvCLAHSNSCLNPVLYCLVRREFRKALKSLL 404
Cdd:cd15295 208 AICWAPYSLFTI--IRAACEKHRGSPWY----NFAF----WLQWFNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
84-400 1.06e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 53.06  E-value: 1.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  84 ISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSInLFVTNLALTD------FQFVLTLPFWAVENALDFKWPFGKAmcki 157
Cdd:cd14972   1 VLVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMY-ILIANLAAADllagiaFVFTFLSVLLVSLTPSPATWLLRKG---- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 vSMVTSMnmYASVFFLTAMSVTRYHSVASALKSHR--TRGHgrgdccgrslgdsccfsAKALCVWIWALA-ALASLPSAI 234
Cdd:cd14972  76 -SLVLSL--LASAYSLLAIAVDRYISIVHGLTYVNnvTNKR-----------------VKVLIALVWVWSvLLALLPVLG 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 235 FSTTVKVmgEELCLVRFPdkllgrdrqfwlgLYHSQKVLLGFV---LPLGIIILCYLLLVRFI---ADRRAAGTKggAAV 308
Cdd:cd14972 136 WNCVLCD--QESCSPLGP-------------GLPKSYLVLILVfffIALVIIVFLYVRIFWCLwrhANAIAARQE--AAV 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 309 aggrptGASARRLSKVTKSVTIVVLSFFLCWLPnqalttwsILIKFNAVPFSQEYFLCQVYAFPVSVcLAHSNSCLNPVL 388
Cdd:cd14972 199 ------PAQPSTSRKLAKTVVIVLGVFLVCWLP--------LLILLVLDVLCPSVCDIQAVFYYFLV-LALLNSAINPII 263
                       330
                ....*....|..
gi 20455271 389 YCLVRREFRKAL 400
Cdd:cd14972 264 YAFRLKEMRRAV 275
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
96-400 1.33e-07

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 52.99  E-value: 1.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  96 LAGNLLVLYLMKSMQGWrKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTA 175
Cdd:cd15959  15 VGGNLLVIVAIAKTPRL-QTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLCA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 176 MSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLpSAIFSTTVKVMGEELCLVRFPDKl 255
Cdd:cd15959  94 IAVDRYLAITNPLRYEALVTKRR---------------ARTAVCLVWAISAAISF-LPIMNQWWRDGADEEAQRCYDNP- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 256 lgRDRQFWLGL-YHSQKVLLGFVLPLGIIILCYLL---------------LVRFIADRraAGTKGGAAVAGGRPTGASAR 319
Cdd:cd15959 157 --RCCDFVTNMpYAIVSSTVSFYVPLLVMIFVYVRvfvvatrqvrlirkdKVRFPPEE--SPPAESRPACGRRPSRLLAI 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYFLCQVYafpvsvcLAHSNSCLNPVLYCLvRREFRKA 399
Cdd:cd15959 233 KEHKALKTLGIIMGTFTLCWLP---FFVANIIKVFCRSLVPDPAFLFLNW-------LGYANSAFNPIIYCR-SPDFRSA 301

                .
gi 20455271 400 L 400
Cdd:cd15959 302 F 302
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
98-400 1.71e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 52.74  E-value: 1.71e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  98 GNLLVLYLM---KSMQgwrkSSINLFVTNLALTDFQF-VLTLPF---WAVENAldfkWPFGKAMCKIVSMVTSMNMYASV 170
Cdd:cd15312  17 GNLMVIISIshfKQLH----SPTNFLILSLAITDFLLgFLVMPYsmvRSVESC----WYFGDLFCKIHSSLDMMLSTTSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 171 FFLTAMSVTRYHSVASALkSHRTRghgrgdccgrslgdSCCFSAKALCVWIWALAALASLpSAIFSTtVKVMGEE----- 245
Cdd:cd15312  89 FHLCFIAVDRYYAVCDPL-HYRTK--------------ITTPVIKVFLVISWSVPCLFAF-GVVFSE-VNLEGIEdyval 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 246 -----LCLVRFpDKLlgrdrqfWlGLYHSqkvLLGFVLPlGIIILCYLLLVRFIADRRAAGTKGGAAVA-GGRPTGASAR 319
Cdd:cd15312 152 vsctgSCVLIF-NKL-------W-GVIAS---LIAFFIP-GTVMIGIYIKIFFVARKHAKVINNRPSVTkGDSKNKLSKK 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPnqalttWSILIKFNavPFSQeyFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15312 219 KERKAAKTLSIVMGVFLLCWLP------FFVATLID--PFLN--FSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKA 288

                .
gi 20455271 400 L 400
Cdd:cd15312 289 F 289
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
82-400 2.01e-07

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 52.29  E-value: 2.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLV---LYLMKSMQgwrkSSINLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKI 157
Cdd:cd15330   1 IITSLFLGTLILCAIFGNACVvaaIALERSLQ----NVANYLIGSLAVTDLMVsVLVLPMAALYQVLN-KWTLGQVTCDL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15330  76 FIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRR---------------AAVLISLTWLIGFSISIPPMLGWR 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEelclvrfPDK-LLGRDRQfwlglYHSQKVLLGFVLPLGIIILCYlllvrfiadrraagtkggaavagGRPTGA 316
Cdd:cd15330 141 TPEDRSD-------PDAcTISKDPG-----YTIYSTFGAFYIPLILMLVLY-----------------------GRIFKA 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 SARRlSKVTKSVTIVVLSFFLCWLPnqalttwsILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15330 186 AARE-RKTVKTLGIIMGTFILCWLP--------FFIVALVLPFCESTCHMPELLGAIINWLGYSNSLLNPIIYAYFNKDF 256

                ....
gi 20455271 397 RKAL 400
Cdd:cd15330 257 QSAF 260
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
82-399 2.21e-07

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 52.05  E-value: 2.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15050   1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVG-NLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLP----SAIFST 237
Cdd:cd15050  80 DYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTR---------------ASLMISGAWLLSFLWVIPilgwHHFARG 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRFpdkllGRDRQFwlglyhsqKVL---LGFVLPLgIIILCYLLLVrFIAdrraagtkggaavaggrpt 314
Cdd:cd15050 145 GERVVLEDKCETDF-----HDVTWF--------KVLtaiLNFYIPS-LLMLWFYAKI-FKA------------------- 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 315 gasARRLSKVTKSVTIVVLSFFLCWLPnqalttwsILIKFNAVPFSQEYFLCQVYAFpvSVCLAHSNSCLNPVLYCLVRR 394
Cdd:cd15050 191 ---VNRERKAAKQLGFIMAAFILCWIP--------YFILFMVIAFCKNCCNENLHMF--TIWLGYINSTLNPFIYPLCNE 257

                ....*
gi 20455271 395 EFRKA 399
Cdd:cd15050 258 NFKKT 262
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
80-400 3.70e-07

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 51.47  E-value: 3.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  80 VRILIsvvyWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVEN-------ALDFKWPFGK 152
Cdd:cd14980   3 LRIFI----WIIGILALIGNILVIIWHISSKKKKKKVPKLLIINLAIADFLMGIYLLIIAIADqyyrgryAQYSEEWLRS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 153 AMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdSCCFSAKALCVWIWAL--AALASL 230
Cdd:cd14980  79 PPCLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLS--------------YKSAKIILILGWLFSIifAAIPIL 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 231 PSAIFSTTVKVMG-EELCLvrfPDKLLGRDRQFWLGLYhsqkVLLGFVLPLgIIILCYLLLVRFIADRRAAGTKggaava 309
Cdd:cd14980 145 YSINQPGDNRLYGySSICM---PSNVSNPYYRGWLIAY----LLLTFIAWI-IICILYILIFISVRKSRKSARR------ 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 310 ggrptgASARRLSKVTKSVTIVVLSFFLCWLPnQALTTWSILIKFNAVPFSQEYFLCqVYAFPVsvclahsNSCLNPVLY 389
Cdd:cd14980 211 ------SSSKRDKRIAIRLALILITDLICWLP-YYIVIFSGLLTSTEIDIHVLQFIA-ILALPL-------NSAINPYLY 275
                       330
                ....*....|.
gi 20455271 390 CLVRREFRKAL 400
Cdd:cd14980 276 TLTTPTFKRDF 286
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
86-291 5.10e-07

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 50.98  E-value: 5.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMkSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDfKWPFGKAMCKIVSMVTSMN 165
Cdd:cd15166   5 VFYSFIFIIGLFVNITALWVF-SCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKD-EWPFGDYFCRILGALTVFY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVMGEE 245
Cdd:cd15166  83 PSIALWLLAFISADRYMAIVQPKHAKELKNTPK---------------AVLACVGVWIMTLASTFPLLFLYEDPDKASNF 147
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 20455271 246 LCLVRFPDKLLGRDrqfwLGLYHSQKVLLGFVLPLGIIILCYLLLV 291
Cdd:cd15166 148 TTCLKMLDIIHLKE----VNVLNFTRLIFFFLIPLFIMIGCYLVII 189
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
82-400 6.65e-07

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 50.64  E-value: 6.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15324   1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQ-NLFLVSLASADILVaTLVIPF-SLANEVMGYWYFGSTWCAFYLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTvk 240
Cdd:cd15324  79 LDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKR---------------IKRMIAVVWVISAVISFPPLLMTKH-- 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 vmGEELCLVrfpdkllgrDRQFWlglYHSQKVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrptgASARR 320
Cdd:cd15324 142 --DEWECLL---------NDETW---YILSSCTVSFFAPGLIMILVYCKIYR-----------------------VAKMR 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPnqalttwsILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15324 185 EKRFTFVLAVVMGVFVLCWFP--------FFFTYSLHAVCRKRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
86-400 7.15e-07

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 50.91  E-value: 7.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALG----LAGNLLVlylMKSMQGWRK--SSINLFVTNLALTDFQFVLT-LPFWAVEnALDFKWPFGKAMCKIV 158
Cdd:cd15317   1 VIIYIVLVLAmlitVSGNLVV---IISISHFKQlhSPTNMLVLSLATADFLLGLCvMPFSMIR-TVETCWYFGDLFCKFH 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASALK---SHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIF 235
Cdd:cd15317  77 TGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRypsKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEGLEEYSSEISCVG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 SttvkvmgeelCLVRFpdkllgrdRQFWlGLYHSqkvlLGFVLPLGIIILCYLLLvrFIADRRAA----GTKGGAAVAGG 311
Cdd:cd15317 157 G----------CQLLF--------NKIW-VLLDF----LTFFIPCLIMIGLYAKI--FLVARRQArkiqNMEDKFRSSEE 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 RPTGASARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAvpfsqeyFLCQVYAFPVSVCLAHSNSCLNPVLYCL 391
Cdd:cd15317 212 NSSKASASRERKAAKTLAIVMGIFLFCWLP---YFIDTIVDEYSN-------FITPAIVFDAVIWLGYFNSAFNPFIYAF 281

                ....*....
gi 20455271 392 VRREFRKAL 400
Cdd:cd15317 282 FYPWFRKAF 290
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
92-400 7.52e-07

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 50.55  E-value: 7.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  92 CALGLA---GNLLVLYLMKSMQGWRKSSInLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFgkAMCKIVSMVTSMNMY 167
Cdd:cd15070   8 ILIGLCavvGNVLVIWVVKLNPSLRTTTF-YFIVSLALADIAVgVLVIPL-AIVVSLGVTIHF--YSCLFMSCLLVVFTH 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 168 ASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdscCFSAKALCvwiWALAALASLpSAIFSTTVKVMGEELC 247
Cdd:cd15070  84 ASIMSLLAIAVDRYLRVKLTVRYRIVTTQRR------------IWLALGLC---WLVSFLVGL-TPMFGWNRKPSLESVN 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 248 LVRFP---DKLLGRDRQFWLGLYhsqkvlLGFVLPLGIIILCYLLLVRFIADRRAAGtkggaaVAGGRPTGASARRLSKV 324
Cdd:cd15070 148 TTPLQcqfTSVMRMDYMVYFSFF------TWILIPLVIMCALYVDIFYIIRNKLSQN------ATGFRETGAFYGREFKT 215
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 325 TKSVTIVVLSFFLCWLPnqalttwsiLIKFNAVpfsqEYFLCQV--YAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15070 216 AKSLALVLFLFAVCWLP---------LSIINCV----VYFNPKVpkIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
82-398 9.30e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 50.21  E-value: 9.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKsMQGWRKSSINLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKIVSM 160
Cdd:cd15301   1 VLIVIVAAVLSLVTVGGNVMVMISFK-IDKQLQTISNYFLFSLAVADFAIgVISMPLFTVYTALG-YWPLGYEVCDTWLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALkSHRTRghgrgdccgRSLGDSCCFSAkalCVWIWALAA----LASLPSAIFS 236
Cdd:cd15301  79 IDYLASNASVLNLLIISFDRYFSVTRPL-TYRAR---------RTTKKAAVMIA---SAWIISLLLwppwIYSWPYIEGK 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 237 TTVKVmgeELCLVRFpdkllgrdrqfwlgLYHSQKVLLG-----FVLPLGIIILCYLLLVRFIADRraagtkggaavagg 311
Cdd:cd15301 146 RTVPA---GTCYIQF--------------LETNPYVTFGtalaaFYVPVTIMCILYWRIWRETKKR-------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 rptgaSARRLSKVTKSVTIVVLSFFLCWLPNQALTTW-SILIKFNAVP---FSQEYFLCQVyafpvsvclahsNSCLNPV 387
Cdd:cd15301 195 -----QKKQESKAAKTLSAILLAFIVTWTPYNVLVLIkAFFPCSDTIPtelWDFSYYLCYI------------NSTINPL 257
                       330
                ....*....|.
gi 20455271 388 LYCLVRREFRK 398
Cdd:cd15301 258 CYALCNAAFRR 268
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
82-399 1.01e-06

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 50.17  E-value: 1.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWaVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15296   1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQG-NFFFLNLAISDFLVgGFCIPLY-IPYVLTGRWKFGRGLCKLWLV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCcgrslgdsccfsAKALCVWIwaLAALASLPSAIFSTTV- 239
Cdd:cd15296  79 VDYLLCTASVFNIVLISYDRFLSVTRAVSYRAQKGMTRQAV------------LKMVLVWV--LAFLLYGPAIISWEYIa 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 --KVMGEELCLVRFpdkllgrdrqFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRaagtkggaavaggrptgAS 317
Cdd:cd15296 145 ggSIIPEGECYAEF----------FYNWYFLMTASTLEFFTPFISVTYFNLSIYLNIQKRR-----------------FR 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLSKVTKSVTIVVLSFFLCWLPnqalttWSILIKFNAVPFSQeyfLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15296 198 LSRDKKVAKSLAIIVCVFGLCWAP------YTLLMIIRAACHGH---CVPDYWYETSFWLLWVNSAINPVLYPLCHMSFR 268

                ..
gi 20455271 398 KA 399
Cdd:cd15296 269 RA 270
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
79-389 1.38e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 49.82  E-value: 1.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  79 RVRILISVVYWVVCALGLAGNLLVLYLMKsmqgwRKSS-INLFVTNLALTDF--QFVLTLPFWAVENALDFKWPFGkaMC 155
Cdd:cd15385   1 KLEIAVLAVIFAVAVIGNSSVLLALYKTK-----KKASrMHLFIKHLSLADLvvAFFQVLPQLCWDITYRFYGPDF--LC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 156 KIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgRSLGdsccfsakaLCVWIWALAALASLP-SAI 234
Cdd:cd15385  74 RIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQPTK-------RSYL---------MIGSAWALSFILSTPqYFI 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 235 FSTTVKVMGEEL--CLVRFPDKLLGRDRQFWLglyhsqkVLLGFVLPLGIIILCYLLLV----RFIADRRAAGTKGGAAV 308
Cdd:cd15385 138 FSLSEIENGSGVydCWANFIVPWGIKAYITWI-------TISIFVVPVIILLTCYGFICyniwRNIKCKTRRGLSDNALK 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 309 AGG-RPTGASARRLS----KVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEyflcqvYAFPVSVCLAHSNSC 383
Cdd:cd15385 211 NILlAVCVSSVKTISrakiRTVKMTFVIVLAYIVCWAPFFTIQMWSVWDQNFPWDESEN------TAVTITALLASLNSC 284

                ....*.
gi 20455271 384 LNPVLY 389
Cdd:cd15385 285 CNPWIY 290
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
86-345 1.45e-06

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 49.81  E-value: 1.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLMKSMQGwRKSSINLFVTNLALTDFQFVL-TLPFWAVENALDFKWPFGKAMCKIVSMVTSM 164
Cdd:cd15198   5 IFLGVILVAGVAGNTTVLCWLCGGRR-RKSRMNFLLLQLALADLLVIGgTALSQIIWELLGDRWMAGDVACRLLKLLQAS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 165 NMYASVFFLTAMSVTRYHSVASALKSHrtrghgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIfstTVKVMGE 244
Cdd:cd15198  84 ARGASANLVVLLALDRHQAIRAPLGQP--------------------LRAWKLAALGWLLALLLALPQAY---VFRVDFP 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 245 ELCLVRFPDKLLGRDRQFWLGLYHSQKVL-----LGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASA- 318
Cdd:cd15198 141 DDPASAWPGHTLCRGIFAPLPRWHLQVYAtyeavVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPSKSHLRAt 220
                       250       260       270
                ....*....|....*....|....*....|...
gi 20455271 319 ------RRLSKVTKSVTIVVLSFFLCWLPNQAL 345
Cdd:cd15198 221 apsalpRAKVKTLKMTLVIALLFVGCSLPYFIA 253
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
82-398 2.32e-06

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 49.09  E-value: 2.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLM---KSMQGWrKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWP--FGKAMCK 156
Cdd:cd15356   1 VLFTAVYALIWALGAAGNALTIHLVlkkRSLRGL-QGTVHYHLVSLALSDLLILLISVPIELYNFVWFHYPwvFGDLVCR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 157 IVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIfs 236
Cdd:cd15356  80 GYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRR---------------TKWLLALIWASSLGFALPMAF-- 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 237 ttvkVMGEELCLV----------RFPDKLLGRDRqfwLGLYHSQKVLLGFVLPLGIIilcylllvrfiadrraagtkgga 306
Cdd:cd15356 143 ----IMGQKYELEtadgepepssRVCTVLVSRAT---LKVFIQVNAFVSFVLPLALI----------------------- 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 307 avAGGRPTGASARRLSKVTKSVTI---VVLSFFLCWLPNQALTtwsilIKFNAVP---FSQEYFLCQVYAFPVSVCLAHS 380
Cdd:cd15356 193 --AFLNGVTVSHLRIQSLQHSVQVlraIVIAYVICWLPYHARR-----LMFCYVPddaWTDSLYNFYHYFYMLTNTLFYV 265
                       330
                ....*....|....*...
gi 20455271 381 NSCLNPVLYCLVRREFRK 398
Cdd:cd15356 266 SSAVNPLLYNVVSSSFRK 283
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
83-400 2.55e-06

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 48.99  E-value: 2.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15219   1 LLAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVPGIFLLNLSFCNLLLtVLNMPF-TLLGVVRNRQPFGDGFCQAVGFL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSH-RTRGHGRGDCCGRSLGDSCCFSAKAL-CVWIWALAALASLpsaifsttv 239
Cdd:cd15219  80 ETFLTSNAMLSMAALSIDRWIAVVFPLSYTsKMRYRDAALMVGYSWLHSLTFSLVALfLSWLGYSSLYASC--------- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 kvmgeELCLVRFPDKllgrdRQF--WLGLYHSqkvlLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrptgas 317
Cdd:cd15219 151 -----TLHLPREEER-----RRFavFTAFFHA----FTFLLSLLVLCVTYLKVLK------------------------- 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSILIKFNAVPFSQEYFLcqvyafpVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15219 192 VRRRQRATKKISIFIGTFVLCFAP---YVITRLVELLPFVTINRYWGI-------VSKCLTYSKAASDPFVYSLLRQQYR 261

                ...
gi 20455271 398 KAL 400
Cdd:cd15219 262 KVL 264
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
83-400 2.65e-06

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 49.02  E-value: 2.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSsINLFVTNLALTDFqfVLTLPFWAVENALDFKWPF--GKAMCKIVSM 160
Cdd:cd15082  15 VLAALMFVVTSLSLAENFAVMLVTFRFKQLRQP-LNYIIVNLSVADF--LVSLTGGTISFLTNARGYFflGVWACVLEGF 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccFSAKALcVWIWALAALASLPSAI--FSTT 238
Cdd:cd15082  92 AVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGK---------------HAALGL-LFVWTFSFIWTIPPVLgwSSYT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 239 VKVMGEELclvrfpdkllgrDRQFWLGLYHSQKVLLGF-----VLPLGIIILCYLLLVRFIadRRAAGTKGGAavaggrp 313
Cdd:cd15082 156 VSKIGTTC------------EPNWYSGNMHDHTYIITFfttcfILPLGVIFVSYGKLLQKL--RKVSNTQGRL------- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 314 tgASARRLSK-VTKSVTIVVLSFFLCWLPnqaLTTWSILIkfNAVP-FSQEYFLCQVYAFpvsvcLAHSNSCLNPVLYCL 391
Cdd:cd15082 215 --GNARKPERqVTRMVVVMIVAFMVCWTP---YAAFSILV--TAHPtIHLDPRLAAIPAF-----FSKTAAVYNPIIYVF 282

                ....*....
gi 20455271 392 VRREFRKAL 400
Cdd:cd15082 283 MNKQFRKCL 291
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
90-400 2.75e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 48.91  E-value: 2.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCkIVSMVTSMNM-YA 168
Cdd:cd15104   8 VLSPLIITGNLLVIVALLKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLC-LLRMCFVITScAA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 169 SVFFLTAMSVTRYHSVASALKSHRTRGHgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTTVKVMGEELCl 248
Cdd:cd15104  87 SVLSLAAIAFDRYLALKQPLRYKQIMTG---------------KSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKC- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 249 vRFPDKLLGRdrqfwlglYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASArRLSKVTKSV 328
Cdd:cd15104 151 -SFFAAFHPR--------VLLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHPRRTL-SDFKAARTV 220
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20455271 329 TIVVLSFFLCWLPNQaltTWSILIKFNAVPFSqeYFLCQVYAFpvsvCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15104 221 AVLIGCFLLSWLPFQ---ITGLVQALCDECKL--YDVLEDYLW----LLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
82-401 3.57e-06

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 48.41  E-value: 3.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15334   1 ILISLTLSILALMTTAINSLVITAIIVTRKLHHPA-NYLICSLAVTDFLVaVLVMPF-SIMYIVKETWIMGQVVCDIWLS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPsAIFSTTVK 240
Cdd:cd15334  79 VDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKH---------------AGIMIAVVWIISIFISMP-PLFWRHQT 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELCLVrfpdkllgRDRQFWLGLYHSqkvLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrptgaSARR 320
Cdd:cd15334 143 TSREDECII--------KHDHIVFTIYST---FGAFYIPLALILILYYKIYR------------------------AATR 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPnqalttwsILIKFNAVPFSQEYFLCQVYAFPVSvCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15334 188 ERKAATTLGLILGAFVICWLP--------FFVKEVIVNTCDSCYISEEMSNFLT-WLGYINSLINPLIYTIFNEDFKKAF 258

                .
gi 20455271 401 K 401
Cdd:cd15334 259 Q 259
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
83-400 4.48e-06

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 48.29  E-value: 4.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLV-LYLMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15008   1 AASLVFGVLWLVSVFGNSLVcLVIHRSRR--TQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVKV 241
Cdd:cd15008  79 QYLTPGVQIYVLLSICVDRFYTIVYPLSFKVSRE-----------------KAKKMIAASWLFDAAFVSPALFFYGSNWG 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEELCLvrfPDKllgrdrqfWLGL-YHSQKVLLGFVLPLGIIILCYLLLVRFIAdrrAAGTKGGAAvagGRPTGASARR 320
Cdd:cd15008 142 PHCNFFL---PDS--------WDGAaYAIIHLLVGFLVPSILIILFYQKVIKYIW---RIGTDGRTV---RRTMNIVPRT 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPNQALTTWSilikfnavPFSQEYFLCQVYAFPVSVcLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15008 205 KVKTIKMFLMLNSMFLLSWLPFYVVQLWH--------PRESDYRQSSLVFLAVTW-ISFSSSASKPTLYSVYNANFRRGM 275
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
81-181 4.57e-06

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 48.25  E-value: 4.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  81 RILISVVYWVVCALGLAGNLLVLYLMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFwAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd14994   1 TYSLIFLYSVVLIGGVIGVILMSFLLVKMN--TRSVTTTAVINLIVVHSLFLLTVPF-RIYYYASKTWKFGMPLCKMVSA 77
                        90       100
                ....*....|....*....|.
gi 20455271 161 VTSMNMYASVFFLTAMSVTRY 181
Cdd:cd14994  78 MIHIHMHLTFLFYVIILVIRY 98
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
82-399 4.74e-06

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 48.25  E-value: 4.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWAVENALDfKWPFGKAMCKIVSM 160
Cdd:cd15056   1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKT-NYFVVSLAVADLLVaVLVMPFGAIELVNN-RWIYGETFCLVRTS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVAsalkshRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVK 240
Cdd:cd15056  79 LDVLLTTASIMHLCCIALDRYYAIC------CQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGIEDLIAFNC 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEELC--LVRFPDKLLGRdrqfwlglyhsqkvLLGFVLPLGIIILCYLLLvrFIADRRAAGTKGGAAVAGGRPTGASA 318
Cdd:cd15056 153 ASGSTSCvfMVNKPFAIICS--------------TVAFYIPALLMVLAYYRI--YVAAREQAHQIRSLQRAGSSNHEADQ 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 319 RRLS------KVTKSVTIVVLSFFLCWLPNQALTTWSILIKfnavpFSQEYFLCQVYAFpvsvcLAHSNSCLNPVLYCLV 392
Cdd:cd15056 217 HRNSrmrtetKAAKTLGIIMGCFCVCWAPFFVTNIVDPFIG-----YRVPYLLWTAFLW-----LGYINSGLNPFLYAFF 286

                ....*..
gi 20455271 393 RREFRKA 399
Cdd:cd15056 287 NKSFRRA 293
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-398 8.89e-06

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 47.25  E-value: 8.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWR--KSSINLFVTNLALTDFQFVLTLPFWAVENALDFK--WPFGKAMCKI 157
Cdd:cd15130   1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQslQSTVRYHLGSLALSDLLILLLAMPVELYNFIWVHhpWAFGDAGCRG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSA-IFS 236
Cdd:cd15130  81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSR---------------TKKFISAIWLASALLAIPMLfTMG 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 237 TTVKVMGEELCLVRFPDKLLGRDRqfwLGLYHSQKVLLGFVLPLGIIilcylllvrfiadrraagtkggaAVAGGRPTGA 316
Cdd:cd15130 146 LQNESDDGTHPGGLVCTPIVDTAT---LKVVIQVNTFMSFLFPMLVT-----------------------SILNTVIANK 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 317 SARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAvpFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREF 396
Cdd:cd15130 200 LVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQ--WTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANF 277

                ..
gi 20455271 397 RK 398
Cdd:cd15130 278 RQ 279
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
90-400 9.01e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 47.64  E-value: 9.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCAlGLAGNLLVLYLMKSMQGWRKSSInLFVTNLALTD-FQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYA 168
Cdd:cd15217  10 IICV-SLAGNLIVSLLVLKDRALHKAPY-YFLLDLCLADtIRSAVCFPFVLVSIRNGSAWTYSVLSCKIVAFMAVLFCFH 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 169 SVFFLTAMSVTRYHSVAsalkSHRtrghgrgdccgrslgdsccFSAKALCVW--------IWALAALASLPSAIFSTTVK 240
Cdd:cd15217  88 AAFMLFCISVTRYMAIA----HHR-------------------FYSKRMTFWtciavicmVWTLSVAMAFPPVFDVGTYK 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 241 VMGEElclvrfpDKLLGRDRqfwlglYHSQKVLLGFVLPLGIIILC----YLLLVRFIADRR------------------ 298
Cdd:cd15217 145 FIREE-------DQCIFEHR------YFKANDTLGFMLMLAVLIVAthivYGKLLLFEYRHRkmkpvqmvpaisqnwtfh 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 299 AAGTKGGAA---VAG-GR----PT--------GASARRL---------SKVTKSVTIVVLSFFLCWLPNQALTTWSILIK 353
Cdd:cd15217 212 GPGATGQAAanwIAGfGRgpmpPTllgirqnaHTANRRLlgmeefkaeKRLGRMFYVITLSFLVLWSPYIVACYWRVFVK 291
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 20455271 354 FNAVPfsQEYFLCQVYafpvsvcLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15217 292 ACSIP--HRYLSTAVW-------MSFAQAGVNPIVCFLLNKDLKKCL 329
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-400 1.04e-05

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 47.14  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQ----FVLTLPFWAVENALDFKWPFgkaMCKI 157
Cdd:cd15099   1 KAIAVLCFLAGPVTFLENILVLLTILSSTALRRRPSYLFIGSLALADMLasviFTISFLDFHVFHQRDSRNLF---LFKL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNMYASVFFLTAmsVTRYHSV--ASALKSHRTRGHgrgdccgrslgdsccfSAKALCVwIWALAALASLPSAIF 235
Cdd:cd15099  78 GGVTMAFTASVGSLLLTA--LDRYLCIyqPSNYKLLVTRTR----------------AKVAILL-MWCVTIIISFLPLMG 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 STTVKVmgEELCLVRFPdkLLGRDR-QFWLGLyhsQKVLLGFvlplgiIILCYLLLVrFIADRRAAGTKGGAAVAGGRPT 314
Cdd:cd15099 139 WRCKTW--DSPCSRLFP--YIDRHYlASWTGL---QLVLLFL------IIYAYPYIL-WKAHRHEANMGGPKLGRQQVKG 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 315 GASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVpfsqeyfLCQVYAFPVSVCLAhsNSCLNPVLYCLVRR 394
Cdd:cd15099 205 QARMRMDIRLAKTLSLILLVLAICWLPVLAFMLVDVRVTLTNK-------QKRMFAFCSMLCLV--NSCVNPIIYALRSR 275

                ....*.
gi 20455271 395 EFRKAL 400
Cdd:cd15099 276 ELRGAM 281
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
91-399 1.05e-05

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 46.99  E-value: 1.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  91 VCALGLAGNLLVLYlmkSMQGWRKSSI--NLFVTNLALTDFQFVL-TLPFWA-VEnaLDFKWPFGKAMCKIVSMVTSMNM 166
Cdd:cd15066   9 IILAAIFGNLLVII---SVMRHRKLRVitNYFVVSLAMADMLVALcAMTFNAsVE--ITGRWMFGYFMCDVWNSLDVYFS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 167 YASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccFSAKALCVWIWAlAALASLPsaIFSTTVKVMGEEL 246
Cdd:cd15066  84 TASILHLCCISVDRYYAIVQPLEYPSKMTKRR-------------VAIMLANVWISP-ALISFLP--IFLGWYTTEEHLQ 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 CLVRFPDKLLGRDRQFWLGLYHSqkvlLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrptgaSARRLSKVTK 326
Cdd:cd15066 148 YRKTHPDQCEFVVNKIYALISSS----VSFWIPCIVMIFTYYRIYL------------------------EAKREHKAAK 199
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455271 327 SVTIVVLSFFLCWLPnqaLTTWSILIKFNAVpfsqeyfLCQVYAFPVSVC--LAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15066 200 TLGIIMGAFILCWLP---FFLWYVTTTLCGD-------ACPYPPILVSILfwIGYFNSTLNPLIYAYFNRDFREA 264
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
94-400 1.11e-05

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 47.16  E-value: 1.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  94 LGLAGNLLVlylMKSMQGWRK--SSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVF 171
Cdd:cd15316  13 LAVFGNLLV---MISILHFKQlhSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 172 FLTAMSVTRYHSVASALkshrtrghgrgdccgrSLGDSCCFSAKALCV---WIWALaalaSLPSAIFSTTVKVMG-EEL- 246
Cdd:cd15316  90 HLCFISVDRYIAVTDPL----------------VYPTKFTVSVSGICIsvsWIFSL----TYSFSVFYTGVNDDGlEELv 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 247 ----CLVRFPDKLlgrdRQFWLGLyhsqkVLLGFVLPLGIIILCY--LLLVRFIADRRAAGTKGGAAVAGGRPTGASARR 320
Cdd:cd15316 150 nalnCVGGCQIIL----NQNWVLV-----DFLLFFIPTFAMIILYgkIFLVAKQQARKIEMTSSKAESSSESYKDRVARR 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 321 LSKVTKSVTIVVLSFFLCWLPnqalttWSILIKFNAVpfsqEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15316 221 ERKAAKTLGITVIAFLVSWLP------YLIDVLIDAF----MNFITPPYIYEICCWCAYYNSAMNPLIYALFYPWFRKAI 290
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
82-400 2.27e-05

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 45.77  E-value: 2.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWAVENALDFkWPFGKAMCKI--- 157
Cdd:cd15049   1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVN-NYFLLSLACADLIIgLVSMNLYTVYLVMGY-WPLGPLLCDLwla 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMnmyASVFFLTAMSVTRYHSVASALK--SHRTRGHgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAIF 235
Cdd:cd15049  79 LDYVASN---ASVMNLLLISFDRYFSVTRPLTyrAKRTPKR-----------------AILMIALAWVISFVLWAPAILG 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 236 STTV---KVMGEELCLVRFPDkllgrDRQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggr 312
Cdd:cd15049 139 WQYFvgeRTVPDGQCYIQFLD-----DPAITFGT-----AIAAFYLPVLVMTILYWRIYRETA----------------- 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 313 ptgasarRLSKVTKSVTIVVLSFFLCWLPnqalttWSILIKFNAvpFSQEYFLCQVYAFpvSVCLAHSNSCLNPVLYCLV 392
Cdd:cd15049 192 -------RERKAARTLSAILLAFIITWTP------YNILVLVST--FCAKCIPDTLWSF--GYWLCYINSTINPFCYALC 254

                ....*...
gi 20455271 393 RREFRKAL 400
Cdd:cd15049 255 NKTFRKTF 262
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
87-306 3.42e-05

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 45.39  E-value: 3.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  87 VYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNM 166
Cdd:cd15169   6 LYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 167 YASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdSCCFSAkALCVWIWAL--------------AALASLPS 232
Cdd:cd15169  86 YAGGGFLAALSAGRYLGAAFPLGYQAFR--------------RPCYSW-GVCAAIWALvlchlglvfgleapGGWLDHSN 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 233 AIFSTTVKVMGEELCLVRFpDKLLGRDRQFWLGlyhsqkvLLGFVLPLGIIILCYLLLVRFIADR--------RAAGTKG 304
Cdd:cd15169 151 TSLGINTPVNGSPVCLEAW-DPASAGPARFSLS-------LLLFFLPLAITAFCYVGCLRALARSglthrrklRAAWVAG 222

                ..
gi 20455271 305 GA 306
Cdd:cd15169 223 GA 224
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
82-399 6.39e-05

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 44.44  E-value: 6.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15404   1 VILSAVMIFILLVSFLGNFVVC-LMVYQKAAMRSAINILLASLAFADMMLaVLNMPF-ALVTIITTRWIFGDAFCRVSAM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVAS---ALKSHRtrghgrgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFST 237
Cdd:cd15404  79 FFWLFVMEGVAILLIISIDRFLIIVQkqdKLNPYR---------------------AKVLIAVSWAVSFCVAFPLAVGSP 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGeelclvRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIadrraagtkggaavaggrptgas 317
Cdd:cd15404 138 DLQIPS------RAPQCVFGYTTNPGYQAYVILIMLIFFFIPFMVMLYSFMGILNTV----------------------- 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 arRLSKVTKSVTIVVL--SFFLCWLPnqaLTTWSILIKFNAVPFSQEYFlcqvyaFPVS---VCLAHSNSCLNPVLYCLV 392
Cdd:cd15404 189 --RSFKTRAFTTILILfiVFTVCWAP---FTTYSLVATFNSHFYHKHNF------FEIStwlLWLCYLKSALNPLIYYWR 257

                ....*..
gi 20455271 393 RREFRKA 399
Cdd:cd15404 258 IKKFRDA 264
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
276-397 6.40e-05

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 44.82  E-value: 6.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 276 FVLPLGIIILCYLLLVrfIADRRAAGTKGGAAvaggrpTGASARRlsKVTKSVTIVVLSFFLCWLPNQALTTWsilikfn 355
Cdd:cd15077 175 FGVPLSIIVFSYGRLL--LTLRAVAKQQEQSA------STQKAER--EVTKMVVVMVLGFLVCWLPYASFALW------- 237
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 20455271 356 AVPFSQEYFLCQVYAFPvsVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15077 238 VVTNRGEPFDLRLASIP--SVFSKASTVYNPVIYVFMNKQFR 277
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
90-397 6.50e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 44.54  E-value: 6.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMkSMQGWRKSSINLFVTNLALTDFQF-VLTLPFwAVENALDFKWPFGKamCKIVSMVTSMNMYA 168
Cdd:cd15069   9 IIAALSVAGNVLVCAAV-GTNSTLQTPTNYFLVSLAAADVAVgLFAIPF-AITISLGFCTDFHS--CLFLACFVLVLTQS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 169 SVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLP---------SAIFSTTV 239
Cdd:cd15069  85 SIFSLLAVAVDRYLAIKVPLRYKSLVTGKR---------------ARGVIAVLWVLAFGIGLTpflgwnkamSATNNSTN 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 ---KVMGEELCLVR-FPDKLLGRDRQFWLGLYhsqkvllGFVLPLGIIILCYLLLVRFIADRRAAGTKggaAVAGGRPTg 315
Cdd:cd15069 150 padHGTNHSCCLIScLFENVVPMSYMVYFNFF-------GCVLPPLLIMLVIYIKIFLVACRQLQRTE---LMDHSRTT- 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 316 asARRLSKVTKSVTIVVLSFFLCWLPNQALttwsilikfNAVPFSQEYF--LCQVYAFPVSVCLAHSNSCLNPVLYCLVR 393
Cdd:cd15069 219 --LQREIHAAKSLAIIVGIFALCWLPVHIL---------NCITLFQPEFskSKPKWAMNVAILLSHANSVVNPIVYAYRN 287

                ....
gi 20455271 394 REFR 397
Cdd:cd15069 288 RDFR 291
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
82-400 7.04e-05

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 44.41  E-value: 7.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15054   1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTS-NYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALKsHRTRghgrgdccgrslGDSCcfSAKALCVWIWALAALASL----------- 230
Cdd:cd15054  80 DVMCCSASILNLCVISLDRYLLIISPLR-YKLR------------MTPP--RALALILAAWTLAALASFlpielgwhelg 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 231 --PSAIFSTTVKVMGEELCLVRFPDKLLGRdrqfwlglyhsqkvLLGFVLPLGIIILCYLLLVRfiadrraagtkggaav 308
Cdd:cd15054 145 heRTLPNLTSGTVEGQCRLLVSLPYALVAS--------------CLTFFLPSGAICFTYCRILL---------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 309 aggrptgaSARRLSKVTKSVTIVVLSFFLCWLPnqalttwsilikFNAVPFSQEYFLCQVYA-FPVSVCLAHSNSCLNPV 387
Cdd:cd15054 195 --------AARKALKASLTLGILLGMFFVTWLP------------FFVANVVQAVCDCVSPGlFDVLTWLGYCNSTMNPI 254
                       330
                ....*....|...
gi 20455271 388 LYCLVRREFRKAL 400
Cdd:cd15054 255 IYPLFMRDFKRAL 267
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
83-400 8.58e-05

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 44.10  E-value: 8.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSsINLFVTNLALTDF-QFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15346   2 LTSVVFIIICCFIILENIFVLLTIWKTKKFHRP-MYYFIGNLALSDLlAGVAYTANLLLSGATTYKLTPTQWFLREGSMF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNmyASVFFLTAMSVTRYhsvasaLKSHRTRGHGRGDCCGRSLGDSCCfsakalcvWIWALAaLASLPsaifsttvkV 241
Cdd:cd15346  81 VALS--ASVFSLLAIAIERY------ITMLKMKLHNGSNSFRSFLLISAC--------WVISLI-LGGLP---------I 134
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 242 MGEElCLVRFpdkllgRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRL 321
Cdd:cd15346 135 MGWN-CISAL------SSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNIRKASRSSEKSM 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 322 SkVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVP--FSQEYFLCqvyafpvsvcLAHSNSCLNPVLYCLVRREFRKA 399
Cdd:cd15346 208 A-LLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCSilFKAEYFLV----------LAVLNSATNPIIYTLTNKEMRRA 276

                .
gi 20455271 400 L 400
Cdd:cd15346 277 F 277
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
264-400 9.48e-05

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 44.04  E-value: 9.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 264 LGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAavagGRPTGASARRLSK---VTKSVTIVVLSFFLCWL 340
Cdd:cd15348 150 LPLYAKSYILFCITVFLAILAAIVVLYARIYRIVKANSQRLGA----LPTRKGRARRSQKylaLLKTVTIVLGTFVACWL 225
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20455271 341 PNQALTTWSILIKFNAVP--FSQEYFLCqvyafpvsvcLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15348 226 PLFLLLLLDVSCPAQACPvlLKADYFLG----------LAMINSLLNPIIYTLTSRDMRRAI 277
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
96-397 1.22e-04

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 43.67  E-value: 1.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  96 LAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQF-VLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLT 174
Cdd:cd15308  15 IAGNVLVC-LSVCTERALKTTTNYFIVSLAVADLLLaLLVLPLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLC 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 175 AMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVrfpdk 254
Cdd:cd15308  94 AISVDRFIAVSVPLNYNRRQGSVR---------------QLLLISATWILSFAVASPVIFGLNNVPNRDPAVCKL----- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 255 llgRDRQFWlgLYHSqkvLLGFVLPlgiiilCYLLLVRFIADRRAAGtkggaavaggrptgasarRLSKVTKSVTIVVLS 334
Cdd:cd15308 154 ---EDNNYV--VYSS---VCSFFIP------CPVMLVLYCAMFRGLG------------------RERKAMRVLPVVVGA 201
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 335 FFLCWLPnqalttwsilikFNAVPFSQEyfLCQVYAFPVSVC-----LAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15308 202 FLFCWTP------------FFVVHITRA--LCESCSIPPQLIsivtwLGYVNSALNPVIYTVFNAEFR 255
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
90-406 1.30e-04

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 43.59  E-value: 1.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMKSMQgwRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFgkAMCKIVSMVTSMNMYAS 169
Cdd:cd15106   9 IISLVGLTGNAVVLWLLGFRM--RRNAFSVYILNLAAADFLFLCCHIIDSLLRLINIFHII--SIPKILTNVMTFPYFAG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 170 VFFLTAMSVTRYHSVASAL--KSHRTRghgrgdccgrslgdsccFSAKALCVWIWALAALASLPSAIFSTTvkvmgeelc 247
Cdd:cd15106  85 LSMLSAISTERCLSVLWPIwyRCHRPR-----------------HLSAVVCVLLWALSLLLSILEWKFCGF--------- 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 248 LVRFPDKLLGRDRQF----WLGLYHSqkVLLGFVLPLGIIILCylllvrfiadrraagtkggaavaggrptGASARRLSK 323
Cdd:cd15106 139 LFSGADSHWCQTFDFittaWLIFLFV--VLCGSSLALLVRILC----------------------------GSRKMPLTR 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 324 VTKSVTIVVLSFFLCWLPNQALttWSILIKFnavPFSQEYFLCQVYafPVSVCLAHSNSCLNPVLYCLV----RREFRKA 399
Cdd:cd15106 189 LYVTILLTVLVFLLCGLPFGIQ--WFLLLWI---HIDLEVLFCHVY--LVSVVLSCLNSSANPIIYFFVgsfrQRQNRQN 261

                ....*..
gi 20455271 400 LKSLLWR 406
Cdd:cd15106 262 LKLVLQR 268
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
96-400 1.34e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 43.67  E-value: 1.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  96 LAGNLLVLyLMKSMQGWRKSSINLFVTNLALTDFQF-VLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLT 174
Cdd:cd15306  15 IGGNILVI-LAVSLEKKLQYATNYFLMSLAVADLLVgLFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLC 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 175 AMSVTRYHSVASALKSHRTRGHGRGdccgrslgdsccfSAKALCVWIWALAALASLPSAIFSTTVKVMGEELClvrfpdk 254
Cdd:cd15306  94 AISLDRYIAIKKPIQASQYNSRATA-------------FIKITVVWLISIGIAIPVPIKGIETDVDNPNNITC------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 255 LLGRDRQFWLGLYHSqkvLLGFVLPLGIIILCYLLLVRFIAdrraagtkggaavaggRPTGASARRLSKVtksVTIVVLS 334
Cdd:cd15306 154 VLTKERFGDFILFGS---LAAFFTPLAIMIVTYFLTIHALR----------------KQTITNEQRASKV---LGIVFFL 211
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20455271 335 FFLCWLPNQALTTWSILIKfnavPFSQEYFLCQVYAFpvsVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15306 212 FLLMWCPFFITNITSVLCD----SCNQTTLQMLMEIF---VWIGYVSSGVNPLVYTLFNKTFRDAF 270
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
264-400 2.18e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 42.84  E-value: 2.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 264 LGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAvaggrptgASARRLSKVTKSVTIVVLSFFLCWLPNQ 343
Cdd:cd15102 150 LPLYSKHYVLFCVTIFAGILAAIVALYARIYCLVRASGRKATRA--------SASPRSLALLKTVLIVLLVFIACWGPLF 221
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 20455271 344 ALTTWSILIKFNAVP--FSQEYFLCqvyafpvsvcLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15102 222 ILLLLDVACPVKTCPilYKADWFLA----------LAVLNSALNPIIYTLRSRELRRAV 270
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
82-400 2.38e-04

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 42.85  E-value: 2.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwrKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMV 161
Cdd:cd15151   1 VVFPVLYTVLFLVGLILNSVAAWIFFHIPS--TSTFIVYLKNTLVADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TSMNMYASVFFLTAMSVTRYHSVASALkshrtrghgrGDCCGRSLGdsccfSAKALCVWIWALAALASLPSAIFS----T 237
Cdd:cd15151  79 FYITMYISIILLGLISFDRYLKIVRPF----------GKSWVQRVR-----FAKILSGAVWLVMFLLSVPNMILSnkpaT 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVmgEELCLVRFPDKLLGRDrqfwlGLYHSQKVLLGFVLPLgiIILCYLLLVRFIADRRAAgtkggaavagGRPTGAS 317
Cdd:cd15151 144 PISV--KKCASLKSPLGLKWHE-----VVNYICQFIFWGVFAL--MVLFYTIISKKVYESYKK----------SRSKDNK 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLSKVtkSVTIVVLSFFLCWLPnqalttwsilIKFNAVPF--SQEYFL--CQV-----YAFPVSVCLAHSNSCLNPVL 388
Cdd:cd15151 205 ASKKTKA--KVFIIVAVFFVCFAP----------FHFVRVPYtlSQTGKItdCQLqnllyIAKEITLWLAATNVCLDPLI 272
                       330
                ....*....|..
gi 20455271 389 YCLVRREFRKAL 400
Cdd:cd15151 273 YIFLCKSFRQRL 284
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
83-398 2.63e-04

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 42.58  E-value: 2.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQgWRKSSINLFVTNLALTDFQFVLTLPFWA----------VENALDfkWPFGK 152
Cdd:cd15964   2 FLRIVVWFVNLLAILGNVFVLLILLTSH-YKLTVPRFLMCNLAFADFCMGIYLLLIAsvdlhtrseyYNHAID--WQTGP 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 153 AmCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRtRGHGRGDCCGRSLGDSCCFsakalcvwiwalaALASLPS 232
Cdd:cd15964  79 G-CNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDR-KIRLRHASAIMLGGWVFCF-------------LLALLPL 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 233 AIFSTTVKVmgeELCLvrfpdkllGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLvrFIADRRaagtkggaavaggr 312
Cdd:cd15964 144 VGVSSYAKV---SICL--------PMDTETPLAQAYIVFVLMLNIIAFVIICACYIKI--YITVRN-------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 313 PTGASARRLSKVTKSVTIVVLSFFLCWLPnqalttwsilIKFNAVPFSQEYFLCQVYAFPVSVCLAHS-NSCLNPVLYCL 391
Cdd:cd15964 197 PQYKSGDKDTKIAKRMAVLIFTDFICMAP----------ISFYALSAILNKPLITVSNSKILLVLFYPlNSCANPFLYAI 266

                ....*..
gi 20455271 392 VRREFRK 398
Cdd:cd15964 267 FTKAFRR 273
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
90-407 2.82e-04

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 42.77  E-value: 2.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  90 VVCALGLAGNLLVLYLMKSMqgWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCK----IVSMVTSMN 165
Cdd:cd15110   9 IICLLGLVGNGIVLWFLGFR--IRRNPFTVYILHLAIADFTFLLCIFILSIMYIGPFNFSHSRDYVAmlifIILFLFGYN 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 166 MYasVFFLTAMSVTRYHSVASAL--KSHRTRghgrgdccgrslgdsccFSAKALCVWIWALAALaslpsaifsttVKVMG 243
Cdd:cd15110  87 TG--LYLLTAISVERCLSVLYPIwyRCHRPK-----------------HQSAIVCGLLWALSVL-----------MTSLE 136
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 244 EELCLVRFPDKllgrdrqfwlglYHSQKVLLGFVLPLGIIILCYLLLVR----FIADRRaagtkggaavaggrptGASAR 319
Cdd:cd15110 137 YLMCIDEGFHV------------RNECRAVLIFIGILTFLVFTPLMLISslilFIKVRC----------------NSQRR 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 320 RLSKVTKSVTIVVLSFFLCWLPNQALttwsILIKFNavpfSQEYFLcqvYAFPVSVCLAHSNSCLNPVLYCLV----RRE 395
Cdd:cd15110 189 HPGKLYIIIMLTVIFFLIFAMPMRVL----LLLNYL----HHSSFL---FSNPVPFLLSTVNSSINPIVYFLVgslrRKR 257
                       330
                ....*....|..
gi 20455271 396 FRKALKSLLWRI 407
Cdd:cd15110 258 IKKSLKVALQRV 269
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
276-400 3.93e-04

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 42.13  E-value: 3.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 276 FVLPLGIIILCYLLLVRFIADrraagtkggaAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPnQALTTWSIlikfn 355
Cdd:cd15080 175 FTIPLIVIFFCYGRLVCTVKE----------AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVP-YASVAFYI----- 238
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 20455271 356 avpFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15080 239 ---FTHQGSDFGPIFMTIPAFFAKSSAVYNPVIYILMNKQFRNCM 280
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
82-400 4.92e-04

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 41.65  E-value: 4.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSiNLFVTNLALTDFQF-VLTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15302   1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPS-NYFIASLAVSDLLIgLESMPFYTVYVLNGDYWPLGWVLCDLWLS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsakalcvWIWALAALASLPSAIFSTTV- 239
Cdd:cd15302  80 VDYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRK---------------------VLLIIAITWIIPALLFFISIf 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 240 ---------KVMGEELCLVRFPdkllgRDRQFWLGLYHSQkvllgFVLPLGIIILCYLLLVRfiadrraagtkggaavag 310
Cdd:cd15302 139 gwqyftgqgRSLPEGECYVQFM-----TDPYFNMGMYIGY-----YWTTLIVMLILYAGIYR------------------ 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 311 grptgaSARRLSKVTKSVTIVVLSFFLCWLPNQALTT-WSILIKFNAVP---FSQEYFLCqvyafpvsvclaHSNSCLNP 386
Cdd:cd15302 191 ------AANRARKALRTITFILGAFVICWTPYHILATiYGFCEAPPCVNetlYTISYYLC------------YMNSPINP 252
                       330
                ....*....|....
gi 20455271 387 VLYCLVRREFRKAL 400
Cdd:cd15302 253 FCYALANQQFKKTF 266
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
82-397 5.43e-04

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 41.70  E-value: 5.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSInLFVTNLALTDFQFVLTLPfwavenaLDFKWPFGKAMCKIVSMV 161
Cdd:cd15163   1 LALMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSV-IYTINLVVTDLLVGLSLP-------TRIVMYYSAGNCLTCSFV 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 162 TS----MNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGrgdccgrslgdsccfSAKALCVWIWALAALASLpsAIFST 237
Cdd:cd15163  73 HIfsyfVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPN---------------YAKGICVFIWLFAIVVTF--SILTT 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELClvrfpdkllgrdRQFWLglyhsqkVLLGFVLPLGIIILCYLLLVrfiadrraagtkggaaVAGGRPT--- 314
Cdd:cd15163 136 AIKFASCCLS------------KLFAL-------TVFEFFLPLLIITFFTIRIM----------------CALSRPGlmh 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 315 GASARRLSKVTKSVTIVVLsFFLCWLPNQALttwSILIKFNAVPFSQEYFLcqvyAFPVSVCLAHSNSCLNPVLYCLVRR 394
Cdd:cd15163 181 QSRERRMRAVQLLITVLII-FMICFTPFHVR---QVAVAFNPDIPHHTSLI----VYHVTVTLSSLNSCMDPIVYCFVTN 252

                ...
gi 20455271 395 EFR 397
Cdd:cd15163 253 NFQ 255
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
277-398 5.73e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 41.85  E-value: 5.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 277 VLPLGIIILCYLLLvrFIADRRAAGTKGGAAVAGGRpTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNA 356
Cdd:cd15068 181 LVPLLLMLGVYLRI--FLAARRQLKQMESQPLPGER-ARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCS 257
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 20455271 357 VPfsqeyflcQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398
Cdd:cd15068 258 HA--------PLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQ 291
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
98-390 8.84e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 41.39  E-value: 8.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  98 GNLLVLYLMKSMQGWrKSSINLFVTNLALTDFQFVLTL-PFWAVENALDfKWPFGKAMCKIVSMVTSMNMYASVFFLTAM 176
Cdd:cd15957  17 GNVLVITAIAKFERL-QTVTNYFITSLACADLVMGLAVvPFGAAHILLK-TWTFGNFWCEFWTSIDVLCVTASIETLCVI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 177 SVTRYHSVASALKShrtrghgrgdccgRSLGDSCcfSAKALCVWIWALAALAS-LP------SAIFSTTVKVMGEELCLV 249
Cdd:cd15957  95 AVDRYFAITSPFKY-------------QSLLTKN--KARVIILMVWIVSGLTSfLPiqmhwyRATHQEAINCYAEETCCD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 250 RFPDKllgrdrqfwlgLYHSQKVLLGFVLPLGIIILCY----------LLLVRFIADR---RAAGTKGGAAVAGGRPTGA 316
Cdd:cd15957 160 FFTNQ-----------AYAIASSIVSFYVPLVIMVFVYsrvfqeakrqLQKIDKSEGRfhnQNIDQNGSGGGGGNRRRSK 228
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20455271 317 SARRLSKVTKSVTIVVLSFFLCWLP----NQALTTWSILIKFNavpfsqeyflcqvyAFPVSVCLAHSNSCLNPVLYC 390
Cdd:cd15957 229 FCLKEHKALKTLGIIMGTFTLCWLPffivNIVHVIQDNLIRKE--------------VYILLNWIGYVNSGFNPLIYC 292
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
82-400 1.11e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 40.98  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQ----FVLTLPFWAVENALDFKWPFgkaMCKI 157
Cdd:cd15341   1 IAIAVLCTLCGLLCILENVAVLYLILSSPKLRRKPSYLFIGSLALADFLasvvFACSFVDFHVFHGVDSSAIF---LLKL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 158 VSMVTSMNmyASVFFLTAMSVTRYHSV--ASALKSHRTRghgrgdccGRSLgdsccfsaKALCVwIWALAALAS-LPsai 234
Cdd:cd15341  78 GGVTMSFT--ASLGSLLLMAFDRYVCIyyPSEYKALVTR--------KRAL--------VALAV-MWVLTALIAyLP--- 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 235 fsttvkVMGEELCLVRFPDKLLgrdrqFWLglyHSQKVLLGFVLPLGIIILCYLLL---VRFIADRRAAGTKGGAAVAGg 311
Cdd:cd15341 136 ------LMGWNCCPLNSPCSEL-----FPL---IPNDYLLSWLLLVAILLSGIIYTyghVLWKAHKHVVYMEKHQDQQG- 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 312 rPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILikfnavpFSQEYFLCQVYAFPVSVCLAhsNSCLNPVLYCL 391
Cdd:cd15341 201 -PGNARMRLDVRLAKTLGLVLAVLLICWSPVLALMMHSLF-------TSLSDHIKKAFAFCSTLCLV--NSMVNPIIYAL 270

                ....*....
gi 20455271 392 VRREFRKAL 400
Cdd:cd15341 271 RSRELRSSL 279
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
83-398 1.19e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 40.61  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  83 LISVVYWVVCALGLAGNLLVLYLMKSMQgWRKSSINLFVTNLALTDFQFVLTLPFWAVEN----------ALDfkWPFGk 152
Cdd:cd15360   2 ILRVLIWFINILAITGNIVVLAILLTSQ-YKLTVPRFLMCNLAFADLCMGIYLLLIASVDirtksqyynyAID--WQTG- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 153 AMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRtRGHGRgdccgrslgdsccfSAKALCVWIWALA-ALASLP 231
Cdd:cd15360  78 AGCAAAGFFTVFASELSVYTLTVITLERWHTITYAMQLDR-KVRLR--------------HAAVIMVGGWIFAfTVALLP 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 232 SAIFSTTVKVmgeELCLvrfPDKLLGRDRQFWLGLyhsqkVLLGFVLPLGIIILCYL---LLVRfiadrraagtkggaav 308
Cdd:cd15360 143 IFGISSYMKV---SICL---PMDIESPLSQAYIIF-----ILVLNVLAFLIICACYIkiyLTVR---------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 309 aggRPTGASARRLSKVTKSVTIVVLSFFLCWLPnqalttwsilIKFNAVPFSQEYFLCQVYAFPVSVCLAHS-NSCLNPV 387
Cdd:cd15360 196 ---NPNFVSSNSDTKIAKRMAVLIFTDFLCMAP----------ISFFAISASLKVPLITVSKSKILLVLFYPiNSCANPF 262
                       330
                ....*....|.
gi 20455271 388 LYCLVRREFRK 398
Cdd:cd15360 263 LYAIFTKTFRR 273
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
273-397 1.26e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 40.61  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 273 LLGFVLPLGIIILCYLLLVRFIAD-RRAAGTKGGAAvaggrptgaSARRLSKVTKSVTIVVLSFFLCWLPnqaLTTWSIL 351
Cdd:cd15085 170 LMCFVIPVAIIGFSYGNVLRSLHKlNKKIEQQGGKN---------CPEEEERAVIMVLAMVIAFLICWLP---YTVFALI 237
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 20455271 352 IKFNAvpfsqeyflcQVYAFPVSVCL----AHSNSCLNPVLYCLVRREFR 397
Cdd:cd15085 238 VVVNP----------ELSISPLAATMptyfAKTSPVYNPIIYIFLNKQFR 277
PHA03234 PHA03234
DNA packaging protein UL33; Provisional
73-397 1.28e-03

DNA packaging protein UL33; Provisional


Pssm-ID: 177562 [Multi-domain]  Cd Length: 338  Bit Score: 40.69  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271   73 SADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSI-NLFVTNLALTDFQFVLTLPFWAVENALDFKwpFG 151
Cdd:PHA03234  24 STPTLKKAQILESAINGIMLTLIIPMIIIVICTLIIYHKVAKHNAtSFYLITLFASDFLHMLCVFFLTLNREALFN--FN 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  152 KAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVasalkSHRTRGHGRGDCCGRSLGdsCCFSAKALCvwiwalaalaSLP 231
Cdd:PHA03234 102 QAFCQCVLFIYHASCSYSICMLAIIATIRYKTL-----HRRKKNDKKNNHIGRNIG--ILFLASAMC----------AIP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  232 SAIFSTTVKVMGEE-LCLVRFPDKllgRDRQFWLGLyhsqKVLLGF---VLPLGIIILCYLLLVRFIADrraagtkggaa 307
Cdd:PHA03234 165 AALFVKTEGKKGNYgKCNIHISSK---KAYDLFIAI----KIVFCFiwgIFPTMIFSFFYVIFCKALHA----------- 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  308 vaggrptgASARRLSKVTKSVTIVVLSFFLCWLPNqaLTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCL-NP 386
Cdd:PHA03234 227 --------LTEKKHKKTLFFIRILILSFLCIQIPN--IAILICEIAFLYIANNSCFGLAQREILQIIIRLMPEIHCFsNP 296
                        330
                 ....*....|.
gi 20455271  387 VLYCLVRREFR 397
Cdd:PHA03234 297 LVYAFTGGDFR 307
7tmA_SREB1_GPR27 cd15216
super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...
149-397 1.50e-03

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320344 [Multi-domain]  Cd Length: 332  Bit Score: 40.78  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 149 PFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVAsalkSHRTRGHgrgdccgRSLGDSCcfsAKALCVWIWALAALA 228
Cdd:cd15216  71 PPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIA----HHRFYAE-------RLAGWPC---AAMLVCAAWALALAA 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 229 SLPSAIFSTTVKVMGEELCLVRFPDKLLGRdrqfwlglyhsqkvlLGFVLPLGIII----LCYLLLVRFIADRR------ 298
Cdd:cd15216 137 AFPPVLDGGGADDEDAPCALEQRPDGAPGA---------------LGFLLLLAAVVgathLVYLRLLFFIHDRRkmrpar 201
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 299 ------------AAGTKGGA---------------AVAGGRPTGA--SARRL---------SKVTKSVTIVVLSFFLCWL 340
Cdd:cd15216 202 lvpavshdwtfhGPGATGQAaanwtagfgrgptppALVGIRPAGPgrGARRLlvleefkteKRLCKMFYAITLLFLLLWG 281
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 20455271 341 PNQALTTWSILIKFNAVPfsqeyflcQVYaFPVSVCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15216 282 PYVVASYLRVLVRPGAVP--------QAY-LTASVWLTFAQAGINPVVCFLFNRELR 329
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
85-188 1.53e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 40.21  E-value: 1.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  85 SVVYWVVCALGLAGNLLVLYLMKsmqgwRKSSI----NLFVTNLALTD-FQFVLTLPfWAVENALDFKWPFGKAMCKIVS 159
Cdd:cd15215   3 SVLIVIFLCASLFGNIVLLLVFQ-----RKPQLlqvaNRFIFNLLVADlLQTVLVMP-WVIATSVPLFWPLDSHLCTALV 76
                        90       100
                ....*....|....*....|....*....
gi 20455271 160 MVTSMNMYASVFFLTAMSVTRYHSVASAL 188
Cdd:cd15215  77 VLMHLFAFAGVNTIVVVSVDRYLAIIHPL 105
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
277-397 2.44e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 39.89  E-value: 2.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 277 VLPLGIIILCYLLLvrFIADRraagtkggaAVAGGRPTGASARRLSK-VTKSVTIVVLSFFLCWLPnqaLTTWSILIKFN 355
Cdd:cd15081 188 IIPLAIIILCYLQV--WLAIR---------AVAQQQKESESTQKAEKeVSRMVVVMIFAYCFCWGP---YTFFACFAAAN 253
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 20455271 356 AvpfsqeyflcqVYAF-PVSVCL----AHSNSCLNPVLYCLVRREFR 397
Cdd:cd15081 254 P-----------GYAFhPLAAALpayfAKSATIYNPIIYVFMNRQFR 289
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
79-404 3.06e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 39.46  E-value: 3.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  79 RVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRkSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIV 158
Cdd:cd15084   8 STYLTVAVLMGMVVALASFVNGLVIVVSIKYKKLR-SPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFE 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 159 SMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGhgrgdccgRSLGDSCCFSakalcvWIWALaaLASLPSAI-FST 237
Cdd:cd15084  87 GFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQ--------RHAVSGCAFT------WGWSL--LWTSPPLFgWSS 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKvmgEELCLVRFPDKLLG--RDRQFWLGLYhsqkvLLGFVLPLGIIILCY---LLLVRfiadrraagtkggAAVAGGR 312
Cdd:cd15084 151 YVP---EGLRTSCGPNWYTGgtNNNSYILALF-----VTCFALPLSTIIFSYsnlLLTLR-------------AVAAQQK 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 313 PTGASARRLSKVTKSVTIVVLSFFLCWLPNQAlttwsilikFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLV 392
Cdd:cd15084 210 ESETTQRAEKEVTRMVIAMVMAFLICWLPYAT---------FAMVVATNKDVVIQPTLASLPSYFSKTATVYNPIIYVFM 280
                       330
                ....*....|..
gi 20455271 393 RREFRKALKSLL 404
Cdd:cd15084 281 NKQFRSCLLELL 292
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
82-400 3.13e-03

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 39.16  E-value: 3.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLfVTNLALTDFQFV-LTLPFWAVENALDFKWPFGKAMCKIVSM 160
Cdd:cd15328   1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNL-VASMAVSDVLVAaLVMPLSLVHELSGRRWQLGRSLCQVWIS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 161 VTSMNMYASVFFLTAMSVTRYHSVASALK-SHRTRGhgrgdccgrslgdscCFSAKALCVwIWALAALASLPSAIF--ST 237
Cdd:cd15328  80 FDVLCCTASIWNVTAIALDRYWSITRHLEyTLRTRR---------------RISNVMIAL-TWALSAVISLAPLLFgwGE 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 238 TVKVMGEELCLVRFPDkllgrdrqfwlglYHSQKVLLGFVLPLGIIILCYLLLVRfiadrraagtkggaavaggrptgaS 317
Cdd:cd15328 144 TYSEDSEECQVSQEPS-------------YTVFSTFGAFYLPLCVVLFVYWKIYK------------------------A 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 318 ARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLcqvyafpvsvCLAHSNSCLNPVLYCLVRREFR 397
Cdd:cd15328 187 AQKEKRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPPIWKSIFL----------WLGYSNSFFNPLIYTAFNKNYN 256

                ...
gi 20455271 398 KAL 400
Cdd:cd15328 257 NAF 259
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
86-400 3.99e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 38.99  E-value: 3.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  86 VVYWVVCALGLAGNLLVLYLM---KSMQgwrkSSINLFVTNLALTDFQFVLT------LPFWAVENALDFKWPFGKAMCK 156
Cdd:cd15350   5 EVFFTIAAVGLLENLLVLVAViknKNLH----SPMYFFICSLAVSDMLGSLYktleniLIILADMGYLNRRGPFETKLDD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 157 IVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWIWALAALASLPSAIFS 236
Cdd:cd15350  81 IMDSLFCLSLLGSIFSILAIAADRYITIFHALRYHNIMTMRR---------------TLVILAIIWTFCGGSGILMILFF 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 237 TTVKVMgeeLCLVrfpdkllgrdrqfwlglyhsqkVLlgFVLPLGIIILCYL---LLVRFIADRRAAGTKGGAAVAGGRP 313
Cdd:cd15350 146 HFVATV---ICFT----------------------VL--FFLMLVLILCLYVhmfLLARSHARKIASLPNHHAQHQRSNM 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 314 TGAsarrlskvtKSVTIVVLSFFLCWLPnqalttWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVR 393
Cdd:cd15350 199 RGA---------ITLTILLGVFVCCWAP------FVLHLLLMMFCPMNPYCACYRSLFQVNGTLIMSHAVIDPAIYAFRS 263

                ....*..
gi 20455271 394 REFRKAL 400
Cdd:cd15350 264 PELRNTF 270
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
313-400 4.11e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 39.00  E-value: 4.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 313 PTGASARRLSKVTKSVTIVVLSFFLCWLPNQALttwsILIKFNAVPFSQEYFLCQVYAFPVSVClahsNSCLNPVLYCLV 392
Cdd:cd15349 192 ISARSRRRSLRLLKTVLMILGAFMVCWGPLFIL----LLVDFFCSSRSCKPLFGMEWVLALAVL----NSAINPLIYSFR 263

                ....*...
gi 20455271 393 RREFRKAL 400
Cdd:cd15349 264 SLEVRRAV 271
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
262-400 4.19e-03

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 39.12  E-value: 4.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 262 FWLGLyhsQKVLLGFVLPLGIIIL------CYLLLVRFIADRRAAGTKGGAAVAGGRPTgaSARRLSKVTKSVTIVVLSF 335
Cdd:cd15340 162 FWIGV---TSVLLLFIVYAYMYILwkahhhAVRMLQRGTQKSIIVYTSEDGKVQTTRPD--QTRMDIRLAKTLVLILVVL 236
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20455271 336 FLCWLPNQALTTWSILIKFNAvpfsqeyFLCQVYAFPVSVCLAhsNSCLNPVLYCLVRREFRKAL 400
Cdd:cd15340 237 IICWGPLLAIMVYDVFGKMNK-------LIKTVFAFCSMLCLL--NSTVNPIIYALRSKDLRHAF 292
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
142-400 4.64e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 39.01  E-value: 4.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 142 NALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRgdccgrslgdsccfsAKALCVWI 221
Cdd:cd15103  66 GYLVPRDSFEQHIDNVIDSMICSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRR---------------AGVIITAI 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 222 WALAALASLPSAIFSTTVKVMgeeLCLVRFpdkllgrdrqfwlglyhsqkvllgfvLPLGIIILCYLLLVRFIADRRAag 301
Cdd:cd15103 131 WVFCTVCGILFIIYSDSVPVI---ICLISM--------------------------FFAMLVLMASLYVHMFLLARSH-- 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 302 TKGGAAVAGGRPTGASARRLSKVTksVTIVVLSFFLCWLPNQALTTWSILIKFNAvpfsqeYFLCQVYAFPVSVCLAHSN 381
Cdd:cd15103 180 VKKIAALPGQRSTRQRANMKGAVT--LTILLGVFIFCWAPFFLHLTLMISCPSNP------YCACYMSHFNVYLILIMCN 251
                       250
                ....*....|....*....
gi 20455271 382 SCLNPVLYCLVRREFRKAL 400
Cdd:cd15103 252 SVIDPLIYAFRSQELRKTF 270
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
91-298 7.31e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 38.47  E-value: 7.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  91 VCALGLAGNLLVLYLMKSMQGWRKSSInLFVTNLALTD-FQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYAS 169
Cdd:cd15218  10 IIGVSVVGNLLISILLVKDKTLHRAPY-YFLLDLCCSDiLRSAICFPFVFTSVKNGSTWTYGTLTCKVIAFLGVLSCFHT 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 170 VFFLTAMSVTRYHSVAsalkSHRtrghgrgdccgrslgdsccFSAKALCVW--------IWALAALASLPSAIFSTTVKV 241
Cdd:cd15218  89 AFMLFCISVTRYLAIA----HHR-------------------FYTKRLTFWtclavicmVWTLSVAMAFPPVLDVGTYSF 145
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20455271 242 MGEElclvrfpDKLLGRDRQFwlglyhSQKVLLGFVLPLGIIILC----YLLLVRFIADRR 298
Cdd:cd15218 146 IREE-------DQCTFQHRSF------RANDSLGFMLLLALILLAtqlvYLKLIFFVHDRR 193
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
80-398 9.27e-03

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 37.92  E-value: 9.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271  80 VRILIsvvyWVVCALGLAGNLLVLYLMKSMQgWRKSSINLFVTNLALTDFQFVLTLPFWA----------VENALDfkWP 149
Cdd:cd15359   3 LRVLI----WFINILAIAGNLIVLFVLLTSR-YKLTVPRFLMCNLSFADFCMGLYLLLIAsvdsqtksqyYNHAID--WQ 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 150 FGkAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRG--HGRGDCCGRslgdsccfsakalcvWIWALAaL 227
Cdd:cd15359  76 TG-SGCSTAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRlrHAILIMLGG---------------WVFSLL-I 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 228 ASLPSAIFSTTVKVmgeELCLVRFPDKLLGrdrQFWLGLyhsqkVLLGFVLPLGIIILCYLLLVrfiadrraagtkggaa 307
Cdd:cd15359 139 AVLPLVGVSNYMKV---SICLPMDIETLLS---QAYILL-----ILVLNVIAFLVICACYIKIY---------------- 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20455271 308 VAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPnqalttwsilIKFNAVPFSQEYFLCQVYAFPVSVCLAHS-NSCLNP 386
Cdd:cd15359 192 LAVQNPELVAKNKDTKIAKRMAILIFTDFTCMAP----------ISFFAISAAFKVPLITVTNSKILLVLFYPiNSCANP 261
                       330
                ....*....|..
gi 20455271 387 VLYCLVRREFRK 398
Cdd:cd15359 262 FLYAIFTKAFRR 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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