|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
23-317 |
1.24e-78 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 265.69 E-value: 1.24e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 23 YTSSSDESEDGRKPRQ-SFNSRETLHEYNQELRRNYNSQSRK----------RKDVEKSTQEIEFCETPPTLCSGYHTDM 91
Cdd:pfam06484 13 YTSSSADSEECRVPTQkSYSSSETLKAFDHDSRMLYGNRVKDmvhkeadefsRQGQNFSLRELGICEPSPRHGLAYCTEM 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 92 hSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDME 171
Cdd:pfam06484 93 -GLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENGPPIPPSSSSSS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 172 APAD--------------------SAQDMQSSPHNQFTFRPLPPPPPPPHACTCARKPP--------------------- 210
Cdd:pfam06484 172 PVEQhsppppslnenqrpllgnnaSHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPnfqnhsrlrtpppplppphkq 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 211 -----PTVDSLQRRSMTTRSQPS----PAAPAPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYP 281
Cdd:pfam06484 252 nqhhhPSINSLNRSSLTNRRNPSpaptASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTGTTPLFCTASPGYP 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 81869786 282 LTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWK 317
Cdd:pfam06484 332 LTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1196-1527 |
3.17e-38 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 147.29 E-value: 3.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1196 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYY----LAMDPmSESLYLSDTNTRKVYKL 1269
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGNLYVADTGNHRIRKI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1270 kslvetkDLSKNFEVVAGTGDQclpfdqsHCGDGGKASEASLNSPRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIG 1347
Cdd:cd14953 104 -------TPDGVVSTLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVAG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1348 snglTSTQPLSCD-SGmdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISENRRVRIIAGRPIHCQVPGIDhflvsk 1424
Cdd:cd14953 170 ----TGGAGYAGDgPA---TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTGTAGFSGDGG------ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1425 vAIHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNGEISIIAGAPTDcdckidpncdcFSGDGGYAKDAKMKAPS 1504
Cdd:cd14953 236 -ATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNNPT 300
|
330 340
....*....|....*....|...
gi 81869786 1505 SLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:cd14953 301 GVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2647-2724 |
1.52e-35 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 130.42 E-value: 1.52e-35
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81869786 2647 EEKNHVLEMARQRAVAQAWTQEQRRLQEGEEGTRVWTEGEKQQLLGTGRVQGYDGYFVLSVEQYLELSDSANNIHFMR 2724
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1490-2423 |
9.41e-31 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 133.34 E-value: 9.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1490 GDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKNQAHLNDMNLYEIASPADQELYQFTVNGTHLHTMNLITRD 1569
Cdd:COG3209 119 VSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLATGLAGS 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1570 YVYNFTYNAEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATK 1649
Cdd:COG3209 199 ALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGAGLDAST 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1650 SNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVALDTSNRENVLMSTNLTATSTIYILKQEN---TQSTYRV 1726
Cdd:COG3209 279 GTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTvggGGSLTLG 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1727 SPDGSLRVTFASGMEINLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSID 1806
Cdd:COG3209 359 GYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTG 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1807 FDHMTRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGK 1886
Cdd:COG3209 439 GGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTTTAGARG 518
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1887 IWSYTYLEKSVMLLLHSQRRYIFEYDQSDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTL 1966
Cdd:COG3209 519 LVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTT 598
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1967 HLGTGRRVLYKYTKQARLSEILYDTTQVTLTYEESSGVIKTIHLMHDGFicTIRYRQTGPLIGRQIFRFSEEGLVNARFD 2046
Cdd:COG3209 599 TTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTGTGVTAGLTTL 676
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 2047 YSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFNANGQVIEVQYEILKAIA 2126
Cdd:COG3209 677 ATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAG 756
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 2127 YWmTIQYDNMGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKIQWRYSYDLNGNINLLSHGNSARLTPL-----R 2201
Cdd:COG3209 757 AL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGGGTDLqdrtyT 835
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 2202 YDLRDRITRLgeiqykmdEDGFLRQRGNDIFEYNSNGLLQKAYNkvSGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLa 2281
Cdd:COG3209 836 YDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATD--PGTTESYTYDANGNLTSRTDGGTTTYTYDALGR- 904
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 2282 nPIRVTHlynhTSAEITSLYYDLQGHliamelssgeeyyvaCDNMGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFEV 2361
Cdd:COG3209 905 -LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAAN 964
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81869786 2362 IIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkP------FNLYSFENNYPVGKI 2423
Cdd:COG3209 965 PLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD------------PiglaggLNLYAYVGNNPVNYV 1020
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
802-827 |
2.43e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.44 E-value: 2.43e-09
10 20
....*....|....*....|....*.
gi 81869786 802 CGDNLDNDGDGLTDCVDPDCCQQSNC 827
Cdd:NF033662 7 CSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1196-1525 |
6.56e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 59.65 E-value: 6.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1196 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVsilelrnrdTRHSTSPAHKYY-LAMDPmSESLYLSDTNTRKVYKLksl 1272
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPATGEF---------TEYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGRI--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1273 veTKDlSKNFEVVAGTGDQCLPFdqshcgdggkaseaslnsprGITVDRHGFIYFVDGT--MIRRIDenavittviGSNG 1350
Cdd:COG4257 86 --DPK-TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLD---------PATG 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1351 LTSTQPLSCDSGMditqvrlewPTDLAVNPmDNSLYVLDNnivlqisENRRVRIIagrpihcqvpGIDHFLVSKVAIHST 1430
Cdd:COG4257 134 EVTEFPLPTGGAG---------PYGIAVDP-DGNLWVTDF-------GANAIGRI----------DPDTGTLTEYALPTP 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1431 LESARAISVSHSGLLFIAETDERKVNRIQqvTTNGEISIIAGAPTDcdckidpncdcfsgdggyakdakmKAPSSLAVSP 1510
Cdd:COG4257 187 GAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGG------------------------ARPYGVAVDG 240
|
330
....*....|....*
gi 81869786 1511 DGTLYVADLGNVRIR 1525
Cdd:COG4257 241 DGRVWFAESGANRIV 255
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
529-720 |
3.65e-06 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 51.16 E-value: 3.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 529 DDCSTNCNGNGECISGHCH-----------------CFPGFLGPdcaRDSCpvlCGG----NGE----------YEKGHC 577
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTP---KASC---CGGvtcgAGQtcdaktntcvYVKGYC 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 578 VC-RNGWKGPECDVPEEQCIDPTCFGHGT---CIMGV-----------------CICV------------PGYKGEICEE 624
Cdd:pfam19232 84 SAdHPCPSGSACDTAKNACIAQPPYGPDSgkgCVRGFgawiweldpatnsgvwrCRCAngslynsahecsPLADQTLCAA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 625 EDcLDPMC------------------------SSHGICVK----GECHCSTGWGGVNCETplpicQEQCSGHGTFLLDTG 676
Cdd:pfam19232 164 EN-LDPNAlvpassvpafaaygwgnqpvlinkSTAGAAVPsplaGVCPCKPGWAGGSCTE-----DRTCNGRGTWNETTG 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 81869786 677 VCSCDPKWTGSDcstelctmECGSHGVCSRgicqceegWVGPTC 720
Cdd:pfam19232 238 QCACNIDFSGHN--------SCGDDNNCTS--------WTGPRC 265
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2345-2423 |
1.65e-05 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 45.18 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 2345 YTPYGDIYHDTyPDFEVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkPF------NLYSFENNY 2418
Cdd:TIGR03696 1 YDPYGEVLSES-GAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD------------PIglggglNLYAYVGNN 67
|
....*
gi 81869786 2419 PVGKI 2423
Cdd:TIGR03696 68 PVNWV 72
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1574-1689 |
3.44e-05 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 49.62 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1574 FTYNAEGDLGAITSSNGNSVHIRRDAGGMPLwlvvpggqvywltISSNGVLKRvsAQGYNLAlmtypgntGLLATKSNEN 1653
Cdd:NF041261 602 YEYNAAGDLTAVITPDGNRSETQYDAWGKAV-------------STTQGGLTR--SMEYDAA--------GRITTLTNEN 658
|
90 100 110
....*....|....*....|....*....|....*..
gi 81869786 1654 GWTTVYEYDPEGHLTNATFPTGEVSSFHSDLE-KLTK 1689
Cdd:NF041261 659 GSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTgKLTQ 695
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
711-754 |
2.20e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 41.07 E-value: 2.20e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 81869786 711 CEEGWVGPTCEeRSC--------HSHCAEHGQCkdgkcECSPGWEGDHCTIA 754
Cdd:pfam01414 1 CDENYYGSTCS-KFCrprddkfgHYTCDANGNK-----VCLPGWTGPYCDKP 46
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
651-794 |
3.00e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.51 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 651 GVNCETPLPICQEQCsghgtflLDTgvcSCDPkwtgSDCSTelCTMECGSHGVCSRGICQCEEGWV--GPTC-EERS--- 724
Cdd:NF041328 18 GAVCPEGLSVCGGAC-------VDL---RSDP----SNCGA--CGVACGAGQTCVAGACGCGPGTVacGGACvDTASdpa 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81869786 725 ----CHSHCAEHGQCKDGKCecspgwegdhctiahyldavRDGCP-GLCFGNGRCT-LDQNGWHCvcqvGWSGTGC 794
Cdd:NF041328 82 hcgaCGAACAPGQVCEGGAC--------------------REACSeGLTRCGGACVdLATDPLHC----GACGVAC 133
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
23-317 |
1.24e-78 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 265.69 E-value: 1.24e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 23 YTSSSDESEDGRKPRQ-SFNSRETLHEYNQELRRNYNSQSRK----------RKDVEKSTQEIEFCETPPTLCSGYHTDM 91
Cdd:pfam06484 13 YTSSSADSEECRVPTQkSYSSSETLKAFDHDSRMLYGNRVKDmvhkeadefsRQGQNFSLRELGICEPSPRHGLAYCTEM 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 92 hSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDME 171
Cdd:pfam06484 93 -GLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENGPPIPPSSSSSS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 172 APAD--------------------SAQDMQSSPHNQFTFRPLPPPPPPPHACTCARKPP--------------------- 210
Cdd:pfam06484 172 PVEQhsppppslnenqrpllgnnaSHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPnfqnhsrlrtpppplppphkq 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 211 -----PTVDSLQRRSMTTRSQPS----PAAPAPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYP 281
Cdd:pfam06484 252 nqhhhPSINSLNRSSLTNRRNPSpaptASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTGTTPLFCTASPGYP 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 81869786 282 LTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWK 317
Cdd:pfam06484 332 LTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1196-1527 |
3.17e-38 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 147.29 E-value: 3.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1196 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYY----LAMDPmSESLYLSDTNTRKVYKL 1269
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGNLYVADTGNHRIRKI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1270 kslvetkDLSKNFEVVAGTGDQclpfdqsHCGDGGKASEASLNSPRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIG 1347
Cdd:cd14953 104 -------TPDGVVSTLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVAG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1348 snglTSTQPLSCD-SGmdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISENRRVRIIAGRPIHCQVPGIDhflvsk 1424
Cdd:cd14953 170 ----TGGAGYAGDgPA---TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTGTAGFSGDGG------ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1425 vAIHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNGEISIIAGAPTDcdckidpncdcFSGDGGYAKDAKMKAPS 1504
Cdd:cd14953 236 -ATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNNPT 300
|
330 340
....*....|....*....|...
gi 81869786 1505 SLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:cd14953 301 GVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2647-2724 |
1.52e-35 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 130.42 E-value: 1.52e-35
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81869786 2647 EEKNHVLEMARQRAVAQAWTQEQRRLQEGEEGTRVWTEGEKQQLLGTGRVQGYDGYFVLSVEQYLELSDSANNIHFMR 2724
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1247-1528 |
6.07e-34 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 134.58 E-value: 6.07e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1247 LAMDPmSESLYLSDTNTRKVYKL--KSLVETkdlsknfevVAGTGDQclpfdqshcG-DGGKASEASLNSPRGITVDRHG 1323
Cdd:cd14953 28 VAVDA-AGNLYVADRGNHRIRKItpDGVVTT---------VAGTGTA---------GfADGGGAAAQFNTPSGVAVDAAG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1324 FIYFVDGT--MIRRIDENAVITTVIGsnglTSTQPLSCDSGMdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISEN 1399
Cdd:cd14953 89 NLYVADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGA--TAAQFNYPTGVAVDAAGN-LYVADtgNHRIRKITPD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1400 RRVRIIAGRPihcqVPGidhFLVSKVAIHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNGEISIIAGAPTDCdc 1479
Cdd:cd14953 162 GVVTTVAGTG----GAG---YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTAG-- 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 81869786 1480 kidpncdcFSGDGGyAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTIS 1528
Cdd:cd14953 230 --------FSGDGG-ATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1490-2423 |
9.41e-31 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 133.34 E-value: 9.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1490 GDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKNQAHLNDMNLYEIASPADQELYQFTVNGTHLHTMNLITRD 1569
Cdd:COG3209 119 VSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLATGLAGS 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1570 YVYNFTYNAEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATK 1649
Cdd:COG3209 199 ALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGAGLDAST 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1650 SNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVALDTSNRENVLMSTNLTATSTIYILKQEN---TQSTYRV 1726
Cdd:COG3209 279 GTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTvggGGSLTLG 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1727 SPDGSLRVTFASGMEINLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSID 1806
Cdd:COG3209 359 GYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTATGTGTG 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1807 FDHMTRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGK 1886
Cdd:COG3209 439 GGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTTTAGARG 518
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1887 IWSYTYLEKSVMLLLHSQRRYIFEYDQSDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTL 1966
Cdd:COG3209 519 LVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTT 598
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1967 HLGTGRRVLYKYTKQARLSEILYDTTQVTLTYEESSGVIKTIHLMHDGFicTIRYRQTGPLIGRQIFRFSEEGLVNARFD 2046
Cdd:COG3209 599 TTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTGTGVTAGLTTL 676
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 2047 YSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFNANGQVIEVQYEILKAIA 2126
Cdd:COG3209 677 ATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAG 756
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 2127 YWmTIQYDNMGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKIQWRYSYDLNGNINLLSHGNSARLTPL-----R 2201
Cdd:COG3209 757 AL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGGGTDLqdrtyT 835
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 2202 YDLRDRITRLgeiqykmdEDGFLRQRGNDIFEYNSNGLLQKAYNkvSGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLa 2281
Cdd:COG3209 836 YDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATD--PGTTESYTYDANGNLTSRTDGGTTTYTYDALGR- 904
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 2282 nPIRVTHlynhTSAEITSLYYDLQGHliamelssgeeyyvaCDNMGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFEV 2361
Cdd:COG3209 905 -LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGAAAN 964
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81869786 2362 IIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkP------FNLYSFENNYPVGKI 2423
Cdd:COG3209 965 PLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD------------PiglaggLNLYAYVGNNPVNYV 1020
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1284-1528 |
9.65e-30 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 122.64 E-value: 9.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1284 VVAGTGDqclpfdqSHCGDGGKASeASLNSPRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIGsnglTSTQPLSCDS 1361
Cdd:cd14953 3 TVAGSGT-------AGFSGGGGTA-ARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAG----TGTAGFADGG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1362 GmdiTQVRLEWPTDLAVNPMDNsLYVLD--NNIVLQISENRRVRIIAGRpihcqvpGIDHFLVSKVAIHSTLESARAISV 1439
Cdd:cd14953 71 G---AAAQFNTPSGVAVDAAGN-LYVADtgNHRIRKITPDGVVSTLAGT-------GTAGFSDDGGATAAQFNYPTGVAV 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1440 SHSGLLFIAETderKVNRIQQVTTNGEISIIAGAPTDcdckidpncdcFSGDGGYAKDAKMKAPSSLAVSPDGTLYVADL 1519
Cdd:cd14953 140 DAAGNLYVADT---GNHRIRKITPDGVVTTVAGTGGA-----------GYAGDGPATAAQFNNPTGVAVDAAGNLYVADR 205
|
....*....
gi 81869786 1520 GNVRIRTIS 1528
Cdd:cd14953 206 GNHRIRKIT 214
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1190-1527 |
4.17e-22 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 98.54 E-value: 4.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1190 NNKLFAPVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELRNRDTRHSTSPAHkyyLAMDPmSESLYLSDTNTRKVY 1267
Cdd:cd05819 4 PGELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGNHRIQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1268 KLkslvetkDLSKNFEVVAGTGDQclpfdqshcGDGGkaseasLNSPRGITVDRHGFIYFVDgTM---IRRIDENAVITT 1344
Cdd:cd05819 80 KF-------DPDGNFLASFGGSGD---------GDGE------FNGPRGIAVDSSGNIYVAD-TGnhrIQKFDPDGEFLT 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1345 VIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPmDNSLYVLDnnivlqiSENRRVRIIA--GRPIhcqvpgidhFLV 1422
Cdd:cd05819 137 TFGSGGSGPGQ--------------FNGPTGVAVDS-DGNIYVAD-------TGNHRIQVFDpdGNFL---------TTF 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1423 -SKVAIHSTLESARAISVSHSGLLFIAETDErkvNRIQqvttngeisiiagaptdcdcKIDPNCDCFSGDGGYA-KDAKM 1500
Cdd:cd05819 186 gSTGTGPGQFNYPTGIAVDSDGNIYVADSGN---NRVQ--------------------VFDPDGAGFGGNGNFLgSDGQF 242
|
330 340
....*....|....*....|....*..
gi 81869786 1501 KAPSSLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:cd05819 243 NRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1311-1535 |
1.63e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 88.14 E-value: 1.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1311 LNSPRGITVDRHGFIYFVDGTM--IRRIDENAVITTVIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPmDNSLYVL 1388
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFGSGDGQ--------------FNEPAGVAVDS-DGNLYVA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1389 DnnivlqiSENRRVRII--AGRPI-HCQVPGIDhflvskvaiHSTLESARAISVSHSGLLFIAETDErkvNRIQQVTTNG 1465
Cdd:cd05819 72 D-------TGNHRIQKFdpDGNFLaSFGGSGDG---------DGEFNGPRGIAVDSSGNIYVADTGN---HRIQKFDPDG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1466 EISIIAGAPTDCDCK--------IDPN-----CDC-------FSGDGGY--------AKDAKMKAPSSLAVSPDGTLYVA 1517
Cdd:cd05819 133 EFLTTFGSGGSGPGQfngptgvaVDSDgniyvADTgnhriqvFDPDGNFlttfgstgTGPGQFNYPTGIAVDSDGNIYVA 212
|
250
....*....|....*...
gi 81869786 1518 DLGNVRIRTISKNQAHLN 1535
Cdd:cd05819 213 DSGNNRVQVFDPDGAGFG 230
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1166-1396 |
1.31e-15 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 80.65 E-value: 1.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1166 VIATIMGNGHQRSVActncNGPAHNNKLFAPVALASGPDGSVYVGDF--NFVRRIFPSGNsvsilelrnrdtrhstspah 1243
Cdd:cd14953 163 VVTTVAGTGGAGYAG----DGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGV-------------------- 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1244 kyylamdpmseslylsdtntrkvyklkslVETkdlsknfevVAGTGDQclPFdqshcGDGGKASEASLNSPRGITVDRHG 1323
Cdd:cd14953 219 -----------------------------VTT---------VAGTGTA--GF-----SGDGGATAAQLNNPTGVAVDAAG 253
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81869786 1324 FIYFVD---GTmIRRIDENAVITTVIGSnglTSTQPLSCDSGmdiTQVRLEWPTDLAVNPmDNSLYVLD--NNIVLQI 1396
Cdd:cd14953 254 NLYVADsgnHR-IRKITPAGVVTTVAGG---GAGFSGDGGPA---TSAQFNNPTGVAVDA-AGNLYVADtgNNRIRKI 323
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1303-1524 |
1.09e-09 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 61.91 E-value: 1.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1303 GGKASEAslNSPRGITVDRHGFIYFVD--GTMIRRIDENaviTTVIGSNGLTSTQPLScdsgmditqvrLEWPTDLAVNP 1380
Cdd:cd14956 100 GSGPGQF--NAPRGVAVDADGNLYVADfgNQRIQKFDPD---GSFLRQWGGTGIEPGS-----------FNYPRGVAVDP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1381 mDNSLYVLDnnivlqiSENRRVriiagrpihcQVPGIDHFLVSKVAIHST----LESARAISVSHSGLLFIAETDErkvN 1456
Cdd:cd14956 164 -DGTLYVAD-------TYNDRI----------QVFDNDGAFLRKWGGRGTgpgqFNYPYGIAIDPDGNVFVADFGN---N 222
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81869786 1457 RIQQVTTNGEISIIAGAPTdcdckidpncdcfSGDGgyakdaKMKAPSSLAVSPDGTLYVADLGNVRI 1524
Cdd:cd14956 223 RIQKFTADGTFLTSWGSPG-------------TGPG------QFKNPWGVVVDADGTVYVADSNNNRV 271
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
802-827 |
2.43e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.44 E-value: 2.43e-09
10 20
....*....|....*....|....*.
gi 81869786 802 CGDNLDNDGDGLTDCVDPDCCQQSNC 827
Cdd:NF033662 7 CSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1314-1524 |
2.49e-09 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 60.76 E-value: 2.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1314 PRGITVDRHGFIYFVDGT--MIRRIDENAVITTVIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPmDNSLYVLD-- 1389
Cdd:cd14956 62 PRGLAVDKDGWLYVADYWgdRIQVFTLTGELQTIGGSSGSGPGQ--------------FNAPRGVAVDA-DGNLYVADfg 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1390 NNIVLQISENRR-VRIIAGRPIHcqvPGidHFLvskvaihstleSARAISVSHSGLLFIAETderKVNRIQQVTTNGEIS 1468
Cdd:cd14956 127 NQRIQKFDPDGSfLRQWGGTGIE---PG--SFN-----------YPRGVAVDPDGTLYVADT---YNDRIQVFDNDGAFL 187
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 81869786 1469 IIAGAPtdcdckidpncdcFSGDGgyakdaKMKAPSSLAVSPDGTLYVADLGNVRI 1524
Cdd:cd14956 188 RKWGGR-------------GTGPG------QFNYPYGIAIDPDGNVFVADFGNNRI 224
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1196-1525 |
6.56e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 59.65 E-value: 6.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1196 PVALASGPDGSVYVGDF--NFVRRIFPSGNSVsilelrnrdTRHSTSPAHKYY-LAMDPmSESLYLSDTNTRKVYKLksl 1272
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPATGEF---------TEYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGRI--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1273 veTKDlSKNFEVVAGTGDQCLPFdqshcgdggkaseaslnsprGITVDRHGFIYFVDGT--MIRRIDenavittviGSNG 1350
Cdd:COG4257 86 --DPK-TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLD---------PATG 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1351 LTSTQPLSCDSGMditqvrlewPTDLAVNPmDNSLYVLDNnivlqisENRRVRIIagrpihcqvpGIDHFLVSKVAIHST 1430
Cdd:COG4257 134 EVTEFPLPTGGAG---------PYGIAVDP-DGNLWVTDF-------GANAIGRI----------DPDTGTLTEYALPTP 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1431 LESARAISVSHSGLLFIAETDERKVNRIQqvTTNGEISIIAGAPTDcdckidpncdcfsgdggyakdakmKAPSSLAVSP 1510
Cdd:COG4257 187 GAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGG------------------------ARPYGVAVDG 240
|
330
....*....|....*
gi 81869786 1511 DGTLYVADLGNVRIR 1525
Cdd:COG4257 241 DGRVWFAESGANRIV 255
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1196-1524 |
2.08e-08 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 57.60 E-value: 2.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1196 PVALASGPDGSVYVGDfnfvrrifpSGNSVsILELRNRDTRHSTSPAHKYY----LAMDPmSESLYLSDTNTRKVYKLks 1271
Cdd:cd14952 12 PGGVAVDAAGNVYVAD---------SGNNR-VLKLAAGSTTQTVLPFTGLYqpqgVAVDA-AGTVYVTDFGNNRVLKL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1272 lvetkdlsknfevVAGTGDQC-LPFdqshcgdggkaseASLNSPRGITVDRHGFIYFVDGTmirridENAVITTVIGSNg 1350
Cdd:cd14952 79 -------------AAGSTTQTvLPF-------------TGLNDPTGVAVDAAGNVYVADTG------NNRVLKLAAGSN- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1351 ltstqplscdsgmdiTQVRLEW-----PTDLAVNPMDNsLYVLDnnivlqiSENRRVRiiagrpihcqvpgidhflvsKV 1425
Cdd:cd14952 126 ---------------TQTVLPFtglsnPDGVAVDGAGN-VYVTD-------TGNNRVL--------------------KL 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1426 AIHST---------LESARAISVSHSGLLFIAETDErkvNRIQQVTtngeisiiAGAPTdcdckidPNCDCFSGdggyak 1496
Cdd:cd14952 163 AAGSTtqtvlpftgLNSPSGVAVDTAGNVYVTDHGN---NRVLKLA--------AGSTT-------PTVLPFTG------ 218
|
330 340
....*....|....*....|....*...
gi 81869786 1497 dakMKAPSSLAVSPDGTLYVADLGNVRI 1524
Cdd:cd14952 219 ---LNGPLGVAVDAAGNVYVADRGNDRV 243
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1192-1405 |
3.67e-08 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 57.30 E-value: 3.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1192 KLFAPVALASGPDGSVYVGDFnFVRRI--F-PSGNSVSILElRNRDTRHSTSPAHkyyLAMDpmSESLYLSDTNTRKVY- 1267
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDGKFLKYFP-EKKDRVKLISPAG---LAID--DGKLYVSDVKKHKVIv 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1268 ------KLKSLVETKD-------------LSKNFEVVAGTGDQ-CLPFDQSHCG----DGGKASEASLNSPRGITVDRHG 1323
Cdd:cd14963 127 fdlegkLLLEFGKPGSepgelsypngiavDEDGNIYVADSGNGrIQVFDKNGKFikelNGSPDGKSGFVNPRGIAVDPDG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1324 FIYFVDgTMIRRI---DENAVITTVIGSNGLtstqplscdsgmDITQVRLewPTDLAVNPmDNSLYVLDnnivlqiSENR 1400
Cdd:cd14963 207 NLYVVD-NLSHRVyvfDEQGKELFTFGGRGK------------DDGQFNL--PNGLFIDD-DGRLYVTD-------RENN 263
|
....*
gi 81869786 1401 RVRII 1405
Cdd:cd14963 264 RVAVY 268
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1308-1527 |
5.76e-07 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 53.48 E-value: 5.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1308 EASLNSPRGITVDRHGFIYFVDGT--MIRRID-ENAVITTVIGSNGLTStqplscdsgmditqvrlewPTDLAVNPmDNS 1384
Cdd:COG4257 55 LGGGSGPHGIAVDPDGNLWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGN 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1385 LYVLDNNivlqiseNRRVRII---AGRpihcqvpgidhflVSKVAIHSTLESARAISVSHSGLLFIAEtdeRKVNRIQQV 1461
Cdd:COG4257 115 LWFTDQG-------GNRIGRLdpaTGE-------------VTEFPLPTGGAGPYGIAVDPDGNLWVTD---FGANAIGRI 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81869786 1462 TT-NGEISIIAGaPTdcdckidpncdcfsgdggyakdaKMKAPSSLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:COG4257 172 DPdTGTLTEYAL-PT-----------------------PGAGPRGLAVDPDGNLWVADTGSGRIGRF 214
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
1311-1524 |
7.33e-07 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 53.32 E-value: 7.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1311 LNSPRGITVDRHGFIYFVD--GTMIRRIDENAVITTVIGSNGLTSTQplscdsgmditqvrLEWPTDLAVNPMDNsLYVL 1388
Cdd:cd14954 70 FDRPAGVAVNSRGRIIVADkdNHRIQVFDLNGRFLLKFGERGTKNGQ--------------FNYPWGVAVDSEGR-IYVS 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1389 DnnivlqiSENRRVRIIA--GRPIH---CQVPGIDHFlvskvaihstlESARAISVSHSGLLFIAETDErkvNRIQQVTT 1463
Cdd:cd14954 135 D-------TRNHRVQVFDsdGQFIRkfgFEGAGPGQL-----------DSPRGVAVNPDGNIVVSDFNN---HRLQVFDP 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1464 NGE-ISIIAGAPTDCDC-------KIDPN-----CDC-------FSGDGGYAK--------DAKMKAPSSLAVSPDGTLY 1515
Cdd:cd14954 194 DGQfLRFFGSEGSGNGQfkrprgvAVDDEgniivADSgnhrvqvFSPDGEFLCsfgtegngEGQFDRPSGVAVTPDGRIV 273
|
....*....
gi 81869786 1516 VADLGNVRI 1524
Cdd:cd14954 274 VVDRGNHRI 282
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1304-1527 |
1.84e-06 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 52.58 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1304 GKASEASLNSPRGITVDRHGFIYFVDgT---MIRRID-ENAVITTVIGsnglTSTQPLSCDSGMDITQVRLEWPTDLAVN 1379
Cdd:cd14951 11 GSFAEASFNEPQGLALLPGNILYVAD-TenhALRKIDlETGTVTTLAG----TGEQGRDGEGGGPGREQPLSSPWDVAWG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1380 PMDNSLYV------------LDNNIVLQISENRRVRIIAGRPIH----CQVPGI----DHFL------------------ 1421
Cdd:cd14951 86 PEDDILYIamagthqiwaydLDTGTCRVFAGSGNEGNRNGPYPHeawfAQPSGLslagWGELfvadsessairavslkdg 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1422 VSKVAIHSTL---------------ESAR-----AISVSHSGLLFIAETDERKVNRIQQVTtnGEISIIAGaptdcdcki 1481
Cdd:cd14951 166 GVKTLVGGTRvgtglfdfgdrdgpgAEALlqhplGVAALPDGSVYVADTYNHKIKRVDPAT--GEVSTLAG--------- 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 81869786 1482 dpncdcfSGDGGYAKDAKMKA-PSSLAVSPDGTLYVADLGNVRIRTI 1527
Cdd:cd14951 235 -------TGKAGYKDLEAQFSePSGLVVDGDGRLYVADTNNHRIRRL 274
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
529-720 |
3.65e-06 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 51.16 E-value: 3.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 529 DDCSTNCNGNGECISGHCH-----------------CFPGFLGPdcaRDSCpvlCGG----NGE----------YEKGHC 577
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTP---KASC---CGGvtcgAGQtcdaktntcvYVKGYC 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 578 VC-RNGWKGPECDVPEEQCIDPTCFGHGT---CIMGV-----------------CICV------------PGYKGEICEE 624
Cdd:pfam19232 84 SAdHPCPSGSACDTAKNACIAQPPYGPDSgkgCVRGFgawiweldpatnsgvwrCRCAngslynsahecsPLADQTLCAA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 625 EDcLDPMC------------------------SSHGICVK----GECHCSTGWGGVNCETplpicQEQCSGHGTFLLDTG 676
Cdd:pfam19232 164 EN-LDPNAlvpassvpafaaygwgnqpvlinkSTAGAAVPsplaGVCPCKPGWAGGSCTE-----DRTCNGRGTWNETTG 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 81869786 677 VCSCDPKWTGSDcstelctmECGSHGVCSRgicqceegWVGPTC 720
Cdd:pfam19232 238 QCACNIDFSGHN--------SCGDDNNCTS--------WTGPRC 265
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1196-1524 |
5.60e-06 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 50.66 E-value: 5.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1196 PVALASGPDGSVYVGDfnfvrrifPSGNSVSILELRNRDT--------RHSTSPAHkyyLAMDPmSESLYLSDTNTRKVY 1267
Cdd:cd14962 14 PYGVAADGRGRIYVAD--------TGRGAVFVFDLPNGKVfvignagpNRFVSPIG---VAIDA-NGNLYVSDAELGKVF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1268 KLkslvetkDLSKNFEVVAGTGDQclpfdqshcgdggkaseasLNSPRGITVDRHG-FIYFVD--GTMIRRIDENAVITT 1344
Cdd:cd14962 82 VF-------DRDGKFLRAIGAGAL-------------------FKRPTGIAVDPAGkRLYVVDtlAHKVKVFDLDGRLLF 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1345 VIGSNGltstqplscdSGmditQVRLEWPTDLAVNPMDNsLYVLDnnivlqiSENRRVRII--AGRPIHC-----QVPGi 1417
Cdd:cd14962 136 DIGKRG----------SG----PGEFNLPTDLAVDRDGN-LYVTD-------TMNFRVQIFdaDGKFLRSfgergDGPG- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1418 dhflvskvaihsTLESARAISVSHSGLLFIAETderKVNRIQQVTTNGEISIIAGAPtdcdckidpncdcFSGDGGYAkd 1497
Cdd:cd14962 193 ------------SFARPKGIAVDSEGNIYVVDA---AFDNVQIFNPEGELLLTVGGP-------------GSGPGEFY-- 242
|
330 340
....*....|....*....|....*..
gi 81869786 1498 akmkAPSSLAVSPDGTLYVADLGNVRI 1524
Cdd:cd14962 243 ----LPSGIAIDKDDRIYVVDQFNRRI 265
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2345-2423 |
1.65e-05 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 45.18 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 2345 YTPYGDIYHDTyPDFEVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNhhiwkqlnllpkPF------NLYSFENNY 2418
Cdd:TIGR03696 1 YDPYGEVLSES-GAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD------------PIglggglNLYAYVGNN 67
|
....*
gi 81869786 2419 PVGKI 2423
Cdd:TIGR03696 68 PVNWV 72
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1851-1891 |
1.93e-05 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 43.73 E-value: 1.93e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 81869786 1851 YSPSG-LVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYT 1891
Cdd:TIGR01643 1 YDAAGrLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1488-1530 |
3.12e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 48.68 E-value: 3.12e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 81869786 1488 FSGDGGyaKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKN 1530
Cdd:cd14953 12 FSGGGG--TAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1574-1689 |
3.44e-05 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 49.62 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1574 FTYNAEGDLGAITSSNGNSVHIRRDAGGMPLwlvvpggqvywltISSNGVLKRvsAQGYNLAlmtypgntGLLATKSNEN 1653
Cdd:NF041261 602 YEYNAAGDLTAVITPDGNRSETQYDAWGKAV-------------STTQGGLTR--SMEYDAA--------GRITTLTNEN 658
|
90 100 110
....*....|....*....|....*....|....*..
gi 81869786 1654 GWTTVYEYDPEGHLTNATFPTGEVSSFHSDLE-KLTK 1689
Cdd:NF041261 659 GSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTgKLTQ 695
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1195-1471 |
4.46e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 47.71 E-value: 4.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1195 APVALASGPDGSVYVGDFNF--VRRIFPSGNSVSILELrnrdtrhSTSPAHKYYLAMDPmSESLYLSDTNTRKVYKLksl 1272
Cdd:COG4257 60 GPHGIAVDPDGNLWFTDNGNnrIGRIDPKTGEITTFAL-------PGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRL--- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1273 vetkDLSKN-FEVVAGTGDQclpfdqshcgdggkaseaslNSPRGITVDRHGFIYFVD--GTMIRRID-ENAVITTVIGS 1348
Cdd:COG4257 129 ----DPATGeVTEFPLPTGG--------------------AGPYGIAVDPDGNLWVTDfgANAIGRIDpDTGTLTEYALP 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1349 NGLTStqplscdsgmditqvrlewPTDLAVNPmDNSLYVLDnnivlqiSENRRVRII---AGRpihcqvpgidhflVSKV 1425
Cdd:COG4257 185 TPGAG-------------------PRGLAVDP-DGNLWVAD-------TGSGRIGRFdpkTGT-------------VTEY 224
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 81869786 1426 AIHSTLESARAISVSHSGLLFIAETDerkVNRIQQVTTNGEISIIA 1471
Cdd:COG4257 225 PLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV 267
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1373-1535 |
2.07e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 45.74 E-value: 2.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1373 PTDLAVNPMDNSLYVLDNNIVLQI--SENRRVRIIAGRPihcqvPGIDHFlvskvaihstlESARAISVSHSGLLFIAET 1450
Cdd:cd14956 15 PRGIAVDADDNVYVADARNGRIQVfdKDGTFLRRFGTTG-----DGPGQF-----------GRPRGLAVDKDGWLYVADY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1451 DErkvNRIQQVTTNGEISIIAGAPTdcdckidpncdcfSGDGGYAkdakmkAPSSLAVSPDGTLYVADLGNVRIRTISKN 1530
Cdd:cd14956 79 WG---DRIQVFTLTGELQTIGGSSG-------------SGPGQFN------APRGVAVDADGNLYVADFGNQRIQKFDPD 136
|
....*
gi 81869786 1531 QAHLN 1535
Cdd:cd14956 137 GSFLR 141
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
711-754 |
2.20e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 41.07 E-value: 2.20e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 81869786 711 CEEGWVGPTCEeRSC--------HSHCAEHGQCkdgkcECSPGWEGDHCTIA 754
Cdd:pfam01414 1 CDENYYGSTCS-KFCrprddkfgHYTCDANGNK-----VCLPGWTGPYCDKP 46
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1199-1346 |
1.68e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 42.96 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1199 LASGPDGSVYVGDFNFVR------RIFPSGnSVSILElrnRDTRHSTSpahkyyLAMDPMSESLYLSDTNTRKVYKLkSL 1272
Cdd:COG3386 98 GVVDPDGRLYFTDMGEYLptgalyRVDPDG-SLRVLA---DGLTFPNG------IAFSPDGRTLYVADTGAGRIYRF-DL 166
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81869786 1273 VETKDLSkNFEVVAgtgdqclpfdQSHCGDGGkaseaslnsPRGITVDRHGFIY--FVDGTMIRRIDENAVITTVI 1346
Cdd:COG3386 167 DADGTLG-NRRVFA----------DLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDGELLGRI 222
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
665-689 |
1.82e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.82e-03
10 20
....*....|....*....|....*
gi 81869786 665 CSGHGTFLLDTGVCSCDPKWTGSDC 689
Cdd:pfam07974 2 CSGRGTCVNQCGKCVCDSGYQGATC 26
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
697-720 |
2.01e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 2.01e-03
10 20
....*....|....*....|....*.
gi 81869786 697 ECGSHGVCSR--GICQCEEGWVGPTC 720
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1496-1530 |
2.67e-03 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 42.31 E-value: 2.67e-03
10 20 30
....*....|....*....|....*....|....*
gi 81869786 1496 KDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKN 1530
Cdd:cd05819 3 GPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPD 37
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
651-794 |
3.00e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.51 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 651 GVNCETPLPICQEQCsghgtflLDTgvcSCDPkwtgSDCSTelCTMECGSHGVCSRGICQCEEGWV--GPTC-EERS--- 724
Cdd:NF041328 18 GAVCPEGLSVCGGAC-------VDL---RSDP----SNCGA--CGVACGAGQTCVAGACGCGPGTVacGGACvDTASdpa 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81869786 725 ----CHSHCAEHGQCKDGKCecspgwegdhctiahyldavRDGCP-GLCFGNGRCT-LDQNGWHCvcqvGWSGTGC 794
Cdd:NF041328 82 hcgaCGAACAPGQVCEGGAC--------------------REACSeGLTRCGGACVdLATDPLHC----GACGVAC 133
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
535-557 |
3.66e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 3.66e-03
10 20
....*....|....*....|....*
gi 81869786 535 CNGNGECIS--GHCHCFPGFLGPDC 557
Cdd:pfam07974 2 CSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
729-751 |
4.73e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.56 E-value: 4.73e-03
10 20
....*....|....*....|....*
gi 81869786 729 CAEHGQCKD--GKCECSPGWEGDHC 751
Cdd:pfam07974 2 CSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1191-1269 |
5.05e-03 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 41.54 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 1191 NKLFAPVALASGPDGSVYVGDF--NFVRRIFPSGNSVSILELrnrdtrhSTSPAHKYYLAMDPMSeSLYLSDTNTRKVYK 1268
Cdd:COG4257 185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPKTGTVTEYPL-------PGGGARPYGVAVDGDG-RVWFAESGANRIVR 256
|
.
gi 81869786 1269 L 1269
Cdd:COG4257 257 F 257
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
595-731 |
7.06e-03 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 39.77 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81869786 595 CIDPTCFGHGTCIMGVCicvpgykGEICEEEDCLDPMCSSHGIC--VKGECHCSTGWGGVNCETPL--PIC------QEQ 664
Cdd:pfam01500 9 CGFPTCSTGGTCGSGCC-------QPCCCQSSCCRPSCCQTSCCqpTTFQSSCCRPTCQPCCQTSCcqPTCcqtsscQTG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81869786 665 CSGHGTFLL-DTGVCSCDPKWTGSDCSTE-LCTMECGSHGVCSRGICQ--------CEEGWVGPTCEERSCHSHCAE 731
Cdd:pfam01500 82 CGGIGYGQEgSSGAVSSRTRWCRPDCRVEgTCLPPCCVVSCTPPTCCQlhhaqascCRPSYCGQSCCRPACCCQCSE 158
|
|
| |
