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Conserved domains on  [gi|81918009|sp|Q9Z2K5|]
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RecName: Full=Target of rapamycin complex subunit LST8; Short=TORC subunit LST8; AltName: Full=G protein beta subunit-like; Short=Protein GbetaL; AltName: Full=Mammalian lethal with SEC13 protein 8; Short=mLST8

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-320 4.41e-59

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 4.41e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGYQH-IRMYDLNSnnPNPIISYDGVSKNI 88
Cdd:COG2319  88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIP 167
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 168 EPEFSITSAHIDPDASYMAAVNSAGNCFVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:COG2319 244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81918009 248 RTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
Cdd:COG2319 316 DLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-320 4.41e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 4.41e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGYQH-IRMYDLNSnnPNPIISYDGVSKNI 88
Cdd:COG2319  88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIP 167
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 168 EPEFSITSAHIDPDASYMAAVNSAGNCFVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:COG2319 244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81918009 248 RTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
Cdd:COG2319 316 DLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-297 1.14e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 151.33  E-value: 1.14e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGYQH-IRMYDLNSNNPnpIISYDGVSKNIASVG 92
Cdd:cd00200  23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGEC--VRTLTGHTSYVSSVA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  93 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIPEPEF 171
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 172 SITSAHIDPDASYMAAVNSAGNCFVWNLTGGigDEVTQLIpktkipAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:cd00200 179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLR------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 81918009 252 FSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 297
Cdd:cd00200 251 GECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 212-247 9.41e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 9.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 81918009    212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
212-247 4.38e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 81918009   212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-114 6.45e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 6.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009   10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQdSQVNALEITPD--RSMIAATGYQHIRMYDLnsNNPN-PIISYDGVSK 86
Cdd:PLN00181 586 ADPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFPSEsgRSLAFGSADHKVYYYDL--RNPKlPLCTMIGHSK 662

                         90       100
                 ....*....|....*....|....*...
gi 81918009   87 NIASVGFhEDGRWMYTGGEDCTARIWDL 114
Cdd:PLN00181 663 TVSYVRF-VDSSTLVSSSTDNTLKLWDL 689
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-320 4.41e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 4.41e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGYQH-IRMYDLNSnnPNPIISYDGVSKNI 88
Cdd:COG2319  88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIP 167
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 168 EPEFSITSAHIDPDASYMAAVNSAGNCFVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:COG2319 244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81918009 248 RTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
Cdd:COG2319 316 DLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
14-297 9.02e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 9.02e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGYQH-IRMYDLNSNNPnpIISYDGVSKNIASVG 92
Cdd:COG2319 134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGtVRLWDLATGKL--LRTLTGHTGAVRSVA 211

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  93 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIPEPEF 171
Cdd:COG2319 212 FSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 172 SITSAHIDPDASYMAAVNSAGNCFVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:COG2319 290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 81918009 252 FSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297
Cdd:COG2319 362 GELLRTL--------TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-297 1.14e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 151.33  E-value: 1.14e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGYQH-IRMYDLNSNNPnpIISYDGVSKNIASVG 92
Cdd:cd00200  23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGEC--VRTLTGHTSYVSSVA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  93 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIPEPEF 171
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 172 SITSAHIDPDASYMAAVNSAGNCFVWNLTGGigDEVTQLIpktkipAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:cd00200 179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLR------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 81918009 252 FSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 297
Cdd:cd00200 251 GECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
8-320 1.06e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 1.06e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009   8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGYQHIRMyDLNSNNPNPIISYDGVSKN 87
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLL-LLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQcQRIFQVNAPINCVCLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIP 167
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 168 EPEFSITSAHIDPDASYMAAVNSAGNCFVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81918009 248 RTSNFSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
Cdd:COG2319 232 DLATGKLLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 COG2319
WD40 repeat [General function prediction only];
14-251 3.55e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.05  E-value: 3.55e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGYQH-IRMYDLNSnnPNPIISYDGVSKNIASVG 92
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGtVRLWDLAT--GKLLRTLTGHSGSVRSVA 253

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  93 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIPEPEF 171
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGhSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 172 SITSAHIDPDASYMAAVNSAGNCFVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:COG2319 332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-248 4.33e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.70  E-value: 4.33e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGYQH-IRMYDLNSNnpNPIISYDGVSKNIASVGF 93
Cdd:cd00200  66 LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKtIKVWDVETG--KCLTTLRGHTDWVNSVAF 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  94 HEDGRWMYTGGEDCTARIWDLRSrnLQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIPEPEFS 172
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRT--GKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81918009 173 ITSAHIDPDASYMAAVNSAGNCFVWNLTGGigdevtqlIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248
Cdd:cd00200 222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTG--------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
92-321 2.96e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.91  E-value: 2.96e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  92 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVcLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIPEPEF 171
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLA-ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 172 SITSAHIDPDASYMAAVNSAGNCFVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGL--------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 252 FSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
Cdd:COG2319 152 GKLLRTLT--------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-156 1.88e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 1.88e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009   8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGY-QHIRMYDLNSnnPNPIISYDGVSK 86
Cdd:cd00200 143 FSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSdGTIKLWDLST--GKCLGTLRGHEN 220

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009  87 NIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLqCQRIFQVNAPINCVCLHPNQAELIVGDQSGTSHIWD 156
Cdd:cd00200 221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-323 2.07e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 2.07e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 172 SITSAHIDPDASYMAAVNSAGNCFVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:cd00200  11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--------LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81918009 252 FSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323
Cdd:cd00200  83 GECVRTL--------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 216-323 5.93e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 5.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSsnpgessrGWMWGCAFSGDSQYIVTASSDNLAR 295
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSSDKTIR 76

                        90       100
                ....*....|....*....|....*...
gi 81918009 296 LWCVETGEIKREYGGHQKAVVCLAFNDS 323
Cdd:cd00200  77 LWDLETGECVRTLTGHTSYVSSVAFSPD 104
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 212-247 9.41e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 9.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 81918009    212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
212-247 4.38e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 81918009   212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
76-113 5.77e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 5.77e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 81918009    76 NPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWD 113
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-114 6.45e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 6.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81918009   10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQdSQVNALEITPD--RSMIAATGYQHIRMYDLnsNNPN-PIISYDGVSK 86
Cdd:PLN00181 586 ADPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFPSEsgRSLAFGSADHKVYYYDL--RNPKlPLCTMIGHSK 662

                         90       100
                 ....*....|....*....|....*...
gi 81918009   87 NIASVGFhEDGRWMYTGGEDCTARIWDL 114
Cdd:PLN00181 663 TVSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 74-113 1.22e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.22e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 81918009     74 NPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWD 113
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 270-297 6.21e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 6.21e-03
                           10        20
                   ....*....|....*....|....*...
gi 81918009    270 RGWMWGCAFSGDSQYIVTASSDNLARLW 297
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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