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Conserved domains on  [gi|20139317|sp|Q9ZIM9|]
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RecName: Full=Molybdopterin synthase catalytic subunit; AltName: Full=MPT synthase subunit 2; AltName: Full=Molybdenum cofactor biosynthesis protein E; AltName: Full=Molybdopterin-converting factor large subunit; AltName: Full=Molybdopterin-converting factor subunit 2

Protein Classification

molybdenum cofactor biosynthesis protein MoaE( domain architecture ID 10001056)

molybdenum cofactor biosynthesis protein MoaE serves as the catalytic subunit of the molybdopterin synthase complex, which catalyzes the conversion of precursor Z into molybdopterin

CATH:  3.90.1170.40
EC:  2.8.1.12
Gene Ontology:  GO:0006777|GO:0030366
PubMed:  35744859
SCOP:  4001136

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 1-135 3.64e-62

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


:

Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 187.31  E-value: 3.64e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317   1 MKQFEIVTEPIQTEQHRDF--TLNPHQGAVVVFTGHVREWTKGIRTEHLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSI 78
Cdd:COG0314   1 MMRVRVTEEPFDLAAELAAlrASDPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 20139317  79 VHRIGPLKISDIAVLIAVSSPHRKDAYAANEYAIDRIKEVVPIWKKEIWEDGAEWIG 135
Cdd:COG0314  81 IHRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVE 137
 
Name Accession Description Interval E-value
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 1-135 3.64e-62

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 187.31  E-value: 3.64e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317   1 MKQFEIVTEPIQTEQHRDF--TLNPHQGAVVVFTGHVREWTKGIRTEHLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSI 78
Cdd:COG0314   1 MMRVRVTEEPFDLAAELAAlrASDPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 20139317  79 VHRIGPLKISDIAVLIAVSSPHRKDAYAANEYAIDRIKEVVPIWKKEIWEDGAEWIG 135
Cdd:COG0314  81 IHRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVE 137
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 11-134 6.79e-56

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 170.78  E-value: 6.79e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317  11 IQTEQHRDFTLNPHQGAVVVFTGHVREWTKGIRTEHLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSIVHRIGPLKISDI 90
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 20139317  91 AVLIAVSSPHRKDAYAANEYAIDRIKEVVPIWKKEIWEDGAEWI 134
Cdd:cd00756  81 IVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGGEEWV 124
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 6-117 5.39e-51

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 158.00  E-value: 5.39e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317     6 IVTEPIQTEQHRDFTLNPHQGAVVVFTGHVREWTKGIRTEHLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSIVHRIGPL 85
Cdd:pfam02391   1 ITEEPLDVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRL 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 20139317    86 KISDIAVLIAVSSPHRKDAYAANEYAIDRIKE 117
Cdd:pfam02391  81 PVGEAIVLVAVSSPHRAEAFEACEYLIDELKA 112
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 23-130 9.22e-37

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 122.10  E-value: 9.22e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317   23 PHQGAVVVFTGHVREWTKGIRTEHLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSIVHRIGPLKISDIAVLIAVSSPHRK 102
Cdd:PLN02390   2 PQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHRA 81

                         90       100
                 ....*....|....*....|....*...
gi 20139317  103 DAYAANEYAIDRIKEVVPIWKKEIWEDG 130
Cdd:PLN02390  82 DALDACKFLIDELKASVPIWKKEVYDDG 109
 
Name Accession Description Interval E-value
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 1-135 3.64e-62

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 187.31  E-value: 3.64e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317   1 MKQFEIVTEPIQTEQHRDF--TLNPHQGAVVVFTGHVREWTKGIRTEHLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSI 78
Cdd:COG0314   1 MMRVRVTEEPFDLAAELAAlrASDPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 20139317  79 VHRIGPLKISDIAVLIAVSSPHRKDAYAANEYAIDRIKEVVPIWKKEIWEDGAEWIG 135
Cdd:COG0314  81 IHRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVE 137
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 11-134 6.79e-56

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 170.78  E-value: 6.79e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317  11 IQTEQHRDFTLNPHQGAVVVFTGHVREWTKGIRTEHLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSIVHRIGPLKISDI 90
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 20139317  91 AVLIAVSSPHRKDAYAANEYAIDRIKEVVPIWKKEIWEDGAEWI 134
Cdd:cd00756  81 IVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGGEEWV 124
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 6-117 5.39e-51

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 158.00  E-value: 5.39e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317     6 IVTEPIQTEQHRDFTLNPHQGAVVVFTGHVREWTKGIRTEHLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSIVHRIGPL 85
Cdd:pfam02391   1 ITEEPLDVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRL 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 20139317    86 KISDIAVLIAVSSPHRKDAYAANEYAIDRIKE 117
Cdd:pfam02391  81 PVGEAIVLVAVSSPHRAEAFEACEYLIDELKA 112
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 23-130 9.22e-37

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 122.10  E-value: 9.22e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317   23 PHQGAVVVFTGHVREWTKGIRTEHLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSIVHRIGPLKISDIAVLIAVSSPHRK 102
Cdd:PLN02390   2 PQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHRA 81

                         90       100
                 ....*....|....*....|....*...
gi 20139317  103 DAYAANEYAIDRIKEVVPIWKKEIWEDG 130
Cdd:PLN02390  82 DALDACKFLIDELKASVPIWKKEVYDDG 109
moaE PRK10678
molybdopterin synthase catalytic subunit MoaE;
26-134 2.80e-26

molybdopterin synthase catalytic subunit MoaE;


Pssm-ID: 182642  Cd Length: 150  Bit Score: 96.74  E-value: 2.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317   26 GAVVVFTGHVREWTKGIRTEHLEYEAYIPMAEKKLAQIGDEINEQWPGTIVSIVHRIGPLKISDIAVLIAVSSPHRKDAY 105
Cdd:PRK10678  29 GAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKALAEIVDEARSRWPLGRVTVIHRVGELWPGDEIVFVGVTSAHRSSAF 108

                         90       100
                 ....*....|....*....|....*....
gi 20139317  106 AANEYAIDRIKEVVPIWKKEIWEDGAEWI 134
Cdd:PRK10678 109 EAGQFIMDYLKTRAPFWKREATPEGDRWV 137
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 26-138 6.84e-25

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 96.22  E-value: 6.84e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139317   26 GAVVVFTGHVR--EWTKGIRTEHLEYEAYIPMAEKKLAQIGDEInEQWPGTI-VSIVHRIGPLKISDIAVLIAVSSPHRK 102
Cdd:PRK14493 160 GAIATFTGRVRakEDADDEPTEYLEFEKYDGVADERMAAIREEL-KQRDGVFeVLLHHRTGVIEAGEDIVFVVVLAGHRQ 238

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 20139317  103 DAYAANEYAIDRIKEVVPIWKKEIWEDGAEWIgHQR 138
Cdd:PRK14493 239 EAFRAVSDGIDRLKDEVPIFKKEVTVDEEFWV-HDR 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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