NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1586112881|gb|QBJ57326|]
View 

pyruvate oxidase (plasmid) [Lactiplantibacillus plantarum]

Protein Classification

acetolactate synthase large subunit family protein( domain architecture ID 1562443)

acetolactate synthase large subunit family protein similar to acetolactate synthase large subunit that is the catalytic subunit of the dimeric enzyme acetolactate synthase, which catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate, the precursor of the branched chain amino acids, valine, isoleucine, and leucine

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK08155 super family cl39075
acetolactate synthase large subunit;
1-579 0e+00

acetolactate synthase large subunit;


The actual alignment was detected with superfamily member PRK08611:

Pssm-ID: 453955 [Multi-domain]  Cd Length: 576  Bit Score: 914.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAI 80
Cdd:PRK08611    2 AKIKAGEALVKLLQDWGIDHVYGIPGDSIDAVVDALRKEQDKIKFIQVRHEEVAALAAAAYAKLTGKIGVCLSIGGPGAI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTI 160
Cdd:PRK08611   82 HLLNGLYDAKMDHVPVLALAGQVTSDLLGTDFFQEVNLEKMFEDVAVYNHQIMSAENLPEIVNQAIRTAYEKKGVAVLTI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 161 PDNLPEQRVSDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFISTLPAKGI 240
Cdd:PRK08611  162 PDDLPAQKIKDTTNKTVDTFRPTVPSPKPKDIKKAAKLINKAKKPVILAGLGAKHAKEELLAFAEKAKIPIIHTLPAKGI 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 241 IGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPKpgRAKSIQINTSASAIGKRYPADVGLVADIKDVIK 320
Cdd:PRK08611  242 IPDDHPYSLGNLGKIGTKPAYEAMQEADLLIMVGTNYPYVDYLPK--KAKAIQIDTDPANIGKRYPVNVGLVGDAKKALH 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 321 QLNssETTILHPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSP 400
Cdd:PRK08611  320 QLT--ENIKHVEDRRFLEACQENMAKWWKWMEEDENNASTPIKPERVMAAIQKIADDDAVLSVDVGTVTVWSARYLNLGT 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 401 TQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQ 480
Cdd:PRK08611  398 NQKFIISSWLGTMGCGLPGAIAAKIAFPDRQAIAICGDGGFSMVMQDFVTAVKYKLPIVVVVLNNQQLAFIKYEQQAAGE 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 481 LNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYV-SDDAPLPGKIVGQEAKGYMKFGSQYL 559
Cdd:PRK08611  478 LEYAIDLSDMDYAKFAEACGGKGYRVEKAEELDPAFEEALA-QDKPVIIDVYVdPNAAPLPGKIVNDEALGYSKWAIKSL 556
                         570       580
                  ....*....|....*....|
gi 1586112881 560 KEEKKIPELPPLKDILRQFF 579
Cdd:PRK08611  557 FEDKKLDQMPPLKKALKRFL 576
 
Name Accession Description Interval E-value
PRK08611 PRK08611
pyruvate oxidase; Provisional
1-579 0e+00

pyruvate oxidase; Provisional


Pssm-ID: 181502 [Multi-domain]  Cd Length: 576  Bit Score: 914.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAI 80
Cdd:PRK08611    2 AKIKAGEALVKLLQDWGIDHVYGIPGDSIDAVVDALRKEQDKIKFIQVRHEEVAALAAAAYAKLTGKIGVCLSIGGPGAI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTI 160
Cdd:PRK08611   82 HLLNGLYDAKMDHVPVLALAGQVTSDLLGTDFFQEVNLEKMFEDVAVYNHQIMSAENLPEIVNQAIRTAYEKKGVAVLTI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 161 PDNLPEQRVSDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFISTLPAKGI 240
Cdd:PRK08611  162 PDDLPAQKIKDTTNKTVDTFRPTVPSPKPKDIKKAAKLINKAKKPVILAGLGAKHAKEELLAFAEKAKIPIIHTLPAKGI 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 241 IGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPKpgRAKSIQINTSASAIGKRYPADVGLVADIKDVIK 320
Cdd:PRK08611  242 IPDDHPYSLGNLGKIGTKPAYEAMQEADLLIMVGTNYPYVDYLPK--KAKAIQIDTDPANIGKRYPVNVGLVGDAKKALH 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 321 QLNssETTILHPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSP 400
Cdd:PRK08611  320 QLT--ENIKHVEDRRFLEACQENMAKWWKWMEEDENNASTPIKPERVMAAIQKIADDDAVLSVDVGTVTVWSARYLNLGT 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 401 TQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQ 480
Cdd:PRK08611  398 NQKFIISSWLGTMGCGLPGAIAAKIAFPDRQAIAICGDGGFSMVMQDFVTAVKYKLPIVVVVLNNQQLAFIKYEQQAAGE 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 481 LNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYV-SDDAPLPGKIVGQEAKGYMKFGSQYL 559
Cdd:PRK08611  478 LEYAIDLSDMDYAKFAEACGGKGYRVEKAEELDPAFEEALA-QDKPVIIDVYVdPNAAPLPGKIVNDEALGYSKWAIKSL 556
                         570       580
                  ....*....|....*....|
gi 1586112881 560 KEEKKIPELPPLKDILRQFF 579
Cdd:PRK08611  557 FEDKKLDQMPPLKKALKRFL 576
IlvB COG0028
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino ...
1-542 2.12e-170

Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439799 [Multi-domain]  Cd Length: 548  Bit Score: 494.68  E-value: 2.12e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQqDQIGFVQVRHeevaslaaaaeaKLTGKLGVCLSIGGPGAI 80
Cdd:COG0028     1 MKMTGADALVEALEAEGVETVFGVPGGAILPLYDALRRQ-SGIRHILVRHeqgaafmadgyaRATGKPGVCLVTSGPGAT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAY-EKHGVAVLT 159
Cdd:COG0028    80 NLVTGLADAYMDSVPVLAITGQVPTSLIGRGAFQEVDQVGLFRPITKWSYLVTDPEDLPEVLRRAFRIATsGRPGPVVLD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 160 IPDNLPEQRVSDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTLPA 237
Cdd:COG0028   160 IPKDVQAAEAEEEPAPPELRGYRPRPAPDPEAIEEAAELLAAAKRPVILAGGGARRAGAaeELRALAERLGAPVVTTLMG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 238 KGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP------YTAYLPKpgrAKSIQINTSASAIGKRYPADVGL 311
Cdd:COG0028   240 KGAFPEDHPLYLGMLGMHGTPAANEALAEADLVLAVGARFDdrvtgnWDEFAPD---AKIIHIDIDPAEIGKNYPVDLPI 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 312 VADIKDVIKQLNSSettiLHPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSW 391
Cdd:COG0028   317 VGDAKAVLAALLEA----LEPRADDRAAWLARIAAWRAEYLAAYAADDGPIKPQRVIAALREALPDDAIVVTDVGQHQMW 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 392 SARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFI 471
Cdd:COG0028   393 AARYLRFRRPRRFLTSGGLGTMGYGLPAAIGAKLARPDRPVVAITGDGGFQMNLQELATAVRYGLPVKVVVLNNGGLGMV 472
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586112881 472 EYEQQAAGQLNY-QIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYVSDDAPLPGK 542
Cdd:COG0028   473 RQWQELFYGGRYsGTDLPNPDFAKLAEAFGAKGERVETPEELEAALEEALA-SDGPALIDVRVDPEENPPGA 543
pyruv_oxi_spxB TIGR02720
pyruvate oxidase; Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an ...
5-577 5.49e-170

pyruvate oxidase; Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an enzyme with FAD and TPP as cofactors that catalyzes the reaction pyruvate + phosphate + O2 + H2O = acetyl phosphate + CO2 + H2O2. It should not be confused with pyruvate dehydrogenase [cytochrome] (EC 1.2.2.2) as in E. coli PoxB, although the E. coli enzyme is closely homologous and has pyruvate oxidase as an alternate name. [Energy metabolism, Aerobic]


Pssm-ID: 213733 [Multi-domain]  Cd Length: 575  Bit Score: 494.74  E-value: 5.49e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   5 ASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILN 84
Cdd:TIGR02720   1 ASAAVLKVLEAWGVDHIYGIPGGSFNSTMDALSAERDRIHYIQVRHEEVGALAAAADAKLTGKIGVCFGSAGPGATHLLN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  85 GLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTIPDNL 164
Cdd:TIGR02720  81 GLYDAKEDHVPVLALVGQVPTTGMNMDTFQEMNENPIYADVAVYNRTAMTAESLPHVIDEAIRRAYAHNGVAVVTIPVDF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 PEQRVSDH-YISSASSFQLTS-PQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFISTLPAKGIIG 242
Cdd:TIGR02720 161 GWQEIPDNdYYASSVSYQTPLlPAPDVEAVTRAVQTLKAAERPVIYYGIGARKAGEELEALSEKLKIPLISTGLAKGIIE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 243 DNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPKPGRAK-SIQINTSASAIGKRYPADVGLVADIKDVIKQ 321
Cdd:TIGR02720 241 DRYPAYLGSAYRVAQKPANEALFQADLVLFVGNNYPFAEVSKAFKNTKyFIQIDIDPAKLGKRHHTDIAVLADAKKALAA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 322 LNSSETTIlhPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPT 401
Cdd:TIGR02720 321 ILAQVEPR--ESTPWWQANVANVKNWRAYLASLEDKTEGPLQAYQVYRAINKIAEDDAIYSIDVGDININSNRHLKMTPK 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 402 QKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQL 481
Cdd:TIGR02720 399 NKWITSNLFATMGVGVPGAIAAKLNYPDRQVFNLAGDGAFSMTMQDLLTQVQYHLPVINIVFSNCTYGFIKDEQEDTNQP 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 482 NYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRV-QNMPVLINAYVSDDAPLPGKIVGQEAKGYMKFGSQYLK 560
Cdd:TIGR02720 479 LIGVDFNDADFAKIAEGVGAVGFRVNKIEQLPAVFEQAKAIkQGKPVLIDAKITGDRPLPVEKLRLDPALSSAADIEAFK 558
                         570
                  ....*....|....*..
gi 1586112881 561 EEKKIPELPPLKDILRQ 577
Cdd:TIGR02720 559 EKYEAQELKPLSTYLKQ 575
TPP_POX cd02014
Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; ...
361-539 8.14e-84

Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. It requires FAD in addition to TPP and a divalent cation as cofactors.


Pssm-ID: 238972 [Multi-domain]  Cd Length: 178  Bit Score: 259.00  E-value: 8.14e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 361 PVAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGA 440
Cdd:cd02014     1 PIHPERVAAELNKRAPDDAIFTIDVGNVTVWAARHLRMNGKQRFILSGLLATMGNGLPGAIAAKLAYPDRQVIALSGDGG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 441 FAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAY 520
Cdd:cd02014    81 FAMLMGDLITAVKYNLPVIVVVFNNSDLGFIKWEQEVMGQPEFGVDLPNPDFAKIAEAMGIKGIRVEDPDELEAALDEAL 160
                         170
                  ....*....|....*....
gi 1586112881 521 RvQNMPVLINAYVSDDAPL 539
Cdd:cd02014   161 A-ADGPVVIDVVTDPNEPP 178
TPP_enzyme_C pfam02775
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;
384-531 1.05e-43

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;


Pssm-ID: 460689 [Multi-domain]  Cd Length: 151  Bit Score: 152.74  E-value: 1.05e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 384 DVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVL 463
Cdd:pfam02775   1 DIGCHQMWAAQYYRFRPPRRYLTSGGLGTMGYGLPAAIGAKLARPDRPVVAIAGDGGFQMNLQELATAVRYNLPITVVVL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586112881 464 NNSKLAFIEYEQQAAGQLNY----QIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINA 531
Cdd:pfam02775  81 NNGGYGMTRGQQTPFGGGRYsgpsGKILPPVDFAKLAEAYGAKGARVESPEELEEALKEALE-HDGPALIDV 151
 
Name Accession Description Interval E-value
PRK08611 PRK08611
pyruvate oxidase; Provisional
1-579 0e+00

pyruvate oxidase; Provisional


Pssm-ID: 181502 [Multi-domain]  Cd Length: 576  Bit Score: 914.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAI 80
Cdd:PRK08611    2 AKIKAGEALVKLLQDWGIDHVYGIPGDSIDAVVDALRKEQDKIKFIQVRHEEVAALAAAAYAKLTGKIGVCLSIGGPGAI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTI 160
Cdd:PRK08611   82 HLLNGLYDAKMDHVPVLALAGQVTSDLLGTDFFQEVNLEKMFEDVAVYNHQIMSAENLPEIVNQAIRTAYEKKGVAVLTI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 161 PDNLPEQRVSDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFISTLPAKGI 240
Cdd:PRK08611  162 PDDLPAQKIKDTTNKTVDTFRPTVPSPKPKDIKKAAKLINKAKKPVILAGLGAKHAKEELLAFAEKAKIPIIHTLPAKGI 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 241 IGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPKpgRAKSIQINTSASAIGKRYPADVGLVADIKDVIK 320
Cdd:PRK08611  242 IPDDHPYSLGNLGKIGTKPAYEAMQEADLLIMVGTNYPYVDYLPK--KAKAIQIDTDPANIGKRYPVNVGLVGDAKKALH 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 321 QLNssETTILHPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSP 400
Cdd:PRK08611  320 QLT--ENIKHVEDRRFLEACQENMAKWWKWMEEDENNASTPIKPERVMAAIQKIADDDAVLSVDVGTVTVWSARYLNLGT 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 401 TQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQ 480
Cdd:PRK08611  398 NQKFIISSWLGTMGCGLPGAIAAKIAFPDRQAIAICGDGGFSMVMQDFVTAVKYKLPIVVVVLNNQQLAFIKYEQQAAGE 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 481 LNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYV-SDDAPLPGKIVGQEAKGYMKFGSQYL 559
Cdd:PRK08611  478 LEYAIDLSDMDYAKFAEACGGKGYRVEKAEELDPAFEEALA-QDKPVIIDVYVdPNAAPLPGKIVNDEALGYSKWAIKSL 556
                         570       580
                  ....*....|....*....|
gi 1586112881 560 KEEKKIPELPPLKDILRQFF 579
Cdd:PRK08611  557 FEDKKLDQMPPLKKALKRFL 576
IlvB COG0028
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino ...
1-542 2.12e-170

Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439799 [Multi-domain]  Cd Length: 548  Bit Score: 494.68  E-value: 2.12e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQqDQIGFVQVRHeevaslaaaaeaKLTGKLGVCLSIGGPGAI 80
Cdd:COG0028     1 MKMTGADALVEALEAEGVETVFGVPGGAILPLYDALRRQ-SGIRHILVRHeqgaafmadgyaRATGKPGVCLVTSGPGAT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAY-EKHGVAVLT 159
Cdd:COG0028    80 NLVTGLADAYMDSVPVLAITGQVPTSLIGRGAFQEVDQVGLFRPITKWSYLVTDPEDLPEVLRRAFRIATsGRPGPVVLD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 160 IPDNLPEQRVSDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTLPA 237
Cdd:COG0028   160 IPKDVQAAEAEEEPAPPELRGYRPRPAPDPEAIEEAAELLAAAKRPVILAGGGARRAGAaeELRALAERLGAPVVTTLMG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 238 KGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP------YTAYLPKpgrAKSIQINTSASAIGKRYPADVGL 311
Cdd:COG0028   240 KGAFPEDHPLYLGMLGMHGTPAANEALAEADLVLAVGARFDdrvtgnWDEFAPD---AKIIHIDIDPAEIGKNYPVDLPI 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 312 VADIKDVIKQLNSSettiLHPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSW 391
Cdd:COG0028   317 VGDAKAVLAALLEA----LEPRADDRAAWLARIAAWRAEYLAAYAADDGPIKPQRVIAALREALPDDAIVVTDVGQHQMW 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 392 SARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFI 471
Cdd:COG0028   393 AARYLRFRRPRRFLTSGGLGTMGYGLPAAIGAKLARPDRPVVAITGDGGFQMNLQELATAVRYGLPVKVVVLNNGGLGMV 472
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586112881 472 EYEQQAAGQLNY-QIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYVSDDAPLPGK 542
Cdd:COG0028   473 RQWQELFYGGRYsGTDLPNPDFAKLAEAFGAKGERVETPEELEAALEEALA-SDGPALIDVRVDPEENPPGA 543
pyruv_oxi_spxB TIGR02720
pyruvate oxidase; Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an ...
5-577 5.49e-170

pyruvate oxidase; Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an enzyme with FAD and TPP as cofactors that catalyzes the reaction pyruvate + phosphate + O2 + H2O = acetyl phosphate + CO2 + H2O2. It should not be confused with pyruvate dehydrogenase [cytochrome] (EC 1.2.2.2) as in E. coli PoxB, although the E. coli enzyme is closely homologous and has pyruvate oxidase as an alternate name. [Energy metabolism, Aerobic]


Pssm-ID: 213733 [Multi-domain]  Cd Length: 575  Bit Score: 494.74  E-value: 5.49e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   5 ASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILN 84
Cdd:TIGR02720   1 ASAAVLKVLEAWGVDHIYGIPGGSFNSTMDALSAERDRIHYIQVRHEEVGALAAAADAKLTGKIGVCFGSAGPGATHLLN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  85 GLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTIPDNL 164
Cdd:TIGR02720  81 GLYDAKEDHVPVLALVGQVPTTGMNMDTFQEMNENPIYADVAVYNRTAMTAESLPHVIDEAIRRAYAHNGVAVVTIPVDF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 PEQRVSDH-YISSASSFQLTS-PQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFISTLPAKGIIG 242
Cdd:TIGR02720 161 GWQEIPDNdYYASSVSYQTPLlPAPDVEAVTRAVQTLKAAERPVIYYGIGARKAGEELEALSEKLKIPLISTGLAKGIIE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 243 DNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPKPGRAK-SIQINTSASAIGKRYPADVGLVADIKDVIKQ 321
Cdd:TIGR02720 241 DRYPAYLGSAYRVAQKPANEALFQADLVLFVGNNYPFAEVSKAFKNTKyFIQIDIDPAKLGKRHHTDIAVLADAKKALAA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 322 LNSSETTIlhPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPT 401
Cdd:TIGR02720 321 ILAQVEPR--ESTPWWQANVANVKNWRAYLASLEDKTEGPLQAYQVYRAINKIAEDDAIYSIDVGDININSNRHLKMTPK 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 402 QKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQL 481
Cdd:TIGR02720 399 NKWITSNLFATMGVGVPGAIAAKLNYPDRQVFNLAGDGAFSMTMQDLLTQVQYHLPVINIVFSNCTYGFIKDEQEDTNQP 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 482 NYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRV-QNMPVLINAYVSDDAPLPGKIVGQEAKGYMKFGSQYLK 560
Cdd:TIGR02720 479 LIGVDFNDADFAKIAEGVGAVGFRVNKIEQLPAVFEQAKAIkQGKPVLIDAKITGDRPLPVEKLRLDPALSSAADIEAFK 558
                         570
                  ....*....|....*..
gi 1586112881 561 EEKKIPELPPLKDILRQ 577
Cdd:TIGR02720 559 EKYEAQELKPLSTYLKQ 575
PRK06457 PRK06457
pyruvate dehydrogenase; Provisional
2-552 1.74e-141

pyruvate dehydrogenase; Provisional


Pssm-ID: 180570 [Multi-domain]  Cd Length: 549  Bit Score: 420.78  E-value: 1.74e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   2 AQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQdqIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIH 81
Cdd:PRK06457    1 MPSVAEVIIRVLEDNGIQRIYGIPGDSIDPLVDAIRKSK--VKYVQVRHEEGAALAASVEAKITGKPSACMGTSGPGSIH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  82 ILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTIP 161
Cdd:PRK06457   79 LLNGLYDAKMDHAPVIALTGQVESDMIGHDYFQEVNLTKLFDDVAVFNQILINPENAEYIIRRAIREAISKRGVAHINLP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 162 DNL----PEQRVSDHYISSASSFqltspQIDdnrLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFISTLPA 237
Cdd:PRK06457  159 VDIlrksSEYKGSKNTEVGKVKY-----SID---FSRAKELIKESEKPVLLIGGGTRGLGKEINRFAEKIGAPIIYTLNG 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 238 KGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPKpgRAKSIQINTSASAIGKRYPADVGLVADIKD 317
Cdd:PRK06457  231 KGILPDLDPKVMGGIGLLGTKPSIEAMDKADLLIMLGTSFPYVNFLNK--SAKVIQVDIDNSNIGKRLDVDLSYPIPVAE 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 318 VIkQLNSSETtilhpDDGFLKACQENVANWNRWMTgKRELD-SKPVAPEALFNDINETAPHNTIYSIDVGTATSWSARFL 396
Cdd:PRK06457  309 FL-NIDIEEK-----SDKFYEELKGKKEDWLDSIS-KQENSlDKPMKPQRVAYIVSQKCKKDAVIVTDTGNVTMWTARHF 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 397 NVSPTQKFILSSYLGTMGCALPGAIAAKI-NYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQ 475
Cdd:PRK06457  382 RASGEQTFIFSAWLGSMGIGVPGSVGASFaVENKRQVISFVGDGGFTMTMMELITAKKYDLPVKIIIYNNSKLGMIKFEQ 461
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586112881 476 QAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRVQNmPVLINAYV-SDDAPLPGKIVGQEAKGYM 552
Cdd:PRK06457  462 EVMGYPEWGVDLYNPDFTKIAESIGFKGFRLEEPKEAEEIIEEFLNTKG-PAVLDAIVdPNERPMPPKLTFKQAGEYV 538
PRK08273 PRK08273
thiamine pyrophosphate protein; Provisional
1-553 5.19e-132

thiamine pyrophosphate protein; Provisional


Pssm-ID: 181344 [Multi-domain]  Cd Length: 597  Bit Score: 398.13  E-value: 5.19e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAI 80
Cdd:PRK08273    1 MSQTVADFILERLREWGVRRVFGYPGDGINGLLGALGRADDKPEFVQARHEEMAAFMAVAHAKFTGEVGVCLATSGPGAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVA-VYNKLISATDNLAEIVDEAIRTAYEKHGVAVLT 159
Cdd:PRK08273   81 HLLNGLYDAKLDHVPVVAIVGQQARAALGGHYQQEVDLQSLFKDVAgAFVQMVTVPEQLRHLVDRAVRTALAERTVTAVI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 160 IPDNLPEQRVSD--------HyissaSSFQLTSPQI--DDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHI 229
Cdd:PRK08273  161 LPNDVQELEYEPpphahgtvH-----SGVGYTRPRVvpYDEDLRRAAEVLNAGRKVAILVGAGALGATDEVIAVAERLGA 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 230 PFISTLPAKGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPKPGRAKSIQINTSASAIGKRYPADV 309
Cdd:PRK08273  236 GVAKALLGKAALPDDLPWVTGSIGLLGTKPSYELMRECDTLLMVGSSFPYSEFLPKEGQARGVQIDIDGRMLGLRYPMEV 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 310 GLVADIKDVIKQLNssETTILHPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTAT 389
Cdd:PRK08273  316 NLVGDAAETLRALL--PLLERKKDRSWRERIEKWVARWWETLEARAMVPADPVNPQRVFWELSPRLPDNAILTADSGSCA 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 390 SWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMV-MQDFITAVKY-----KLPLINIVL 463
Cdd:PRK08273  394 NWYARDLRMRRGMMASLSGTLATMGPAVPYAIAAKFAHPDRPVIALVGDGAMQMNgMAELITVAKYwrqwsDPRLIVLVL 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 464 NNSKLAFIEYEQQA---AGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRVqNMPVLINAYVSDD-APL 539
Cdd:PRK08273  474 NNRDLNQVTWEQRVmegDPKFEASQDLPDVPYARFAELLGLKGIRVDDPEQLGAAWDEALAA-DRPVVLEVKTDPNvPPL 552
                         570
                  ....*....|....
gi 1586112881 540 PGKIVGQEAKGYMK 553
Cdd:PRK08273  553 PPHITLEQAKAFAS 566
PRK09124 PRK09124
ubiquinone-dependent pyruvate dehydrogenase;
1-552 5.32e-117

ubiquinone-dependent pyruvate dehydrogenase;


Pssm-ID: 181661 [Multi-domain]  Cd Length: 574  Bit Score: 358.92  E-value: 5.32e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRkQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAI 80
Cdd:PRK09124    1 MKQTVADYIAKTLEQAGVKRIWGVTGDSLNGLSDSLR-RMGTIEWMHTRHEEVAAFAAGAEAQLTGELAVCAGSCGPGNL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTI 160
Cdd:PRK09124   80 HLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSNPEQLPRVLAIAMRKAILNRGVAVVVL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 161 PDNLPEQRVSDHyiSSASSFQLTSPQI--DDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFISTLPAK 238
Cdd:PRK09124  160 PGDVALKPAPER--ATPHWYHAPQPVVtpAEEELRKLAALLNGSSNITLLCGSGCAGAHDELVALAETLKAPIVHALRGK 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 239 GIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPKpgRAKSIQINTSASAIGKRYPADVGLVADIKDV 318
Cdd:PRK09124  238 EHVEYDNPYDVGMTGLIGFSSGYHAMMNCDTLLMLGTDFPYRQFYPT--DAKIIQIDINPGSLGRRSPVDLGLVGDVKAT 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 319 IKQLNSSETTilHPDDGFLKACQENVAnwnrwmTGKRELDS--------KPVAPEALFNDINETAPHNTIYSIDVGTATS 390
Cdd:PRK09124  316 LAALLPLLEE--KTDRKFLDKALEHYR------KARKGLDDlavpsdggKPIHPQYLARQISEFAADDAIFTCDVGTPTV 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 391 WSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAF 470
Cdd:PRK09124  388 WAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQAAHPGRQVVALSGDGGFSMLMGDFLSLVQLKLPVKIVVFNNSVLGF 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 471 IEYEQQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYrVQNMPVLINAYVS-DDAPLPGKIVGQEAK 549
Cdd:PRK09124  468 VAMEMKAGGYLTDGTDLHNPDFAAIAEACGITGIRVEKASELDGALQRAF-AHDGPALVDVVTAkQELAMPPQIKLEQAK 546

                  ....*.
gi 1586112881 550 G---YM 552
Cdd:PRK09124  547 GfslYM 552
PRK06546 PRK06546
pyruvate dehydrogenase; Provisional
1-551 1.62e-103

pyruvate dehydrogenase; Provisional


Pssm-ID: 180614 [Multi-domain]  Cd Length: 578  Bit Score: 323.86  E-value: 1.62e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDqIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAI 80
Cdd:PRK06546    1 MAKTVAEQLVEQLVAAGVKRIYGIVGDSLNPIVDAVRRTGG-IEWVHVRHEEAAAFAAAAEAQLTGKLAVCAGSCGPGNL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTI 160
Cdd:PRK06546   80 HLINGLYDAHRSGAPVLAIASHIPSAQIGSGFFQETHPDRLFVECSGYCEMVSSAEQAPRVLHSAIQHAVAGGGVSVVTL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 161 PDNLPEQRVSDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFISTLPAKGI 240
Cdd:PRK06546  160 PGDIADEPAPEGFAPSVISPRRPTVVPDPAEVRALADAINEAKKVTLFAGAGVRGAHAEVLALAEKIKAPVGHSLRGKEW 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 241 IGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPKpgrAKSIQINTSASAIGKRYPADVGLVADIKDVIK 320
Cdd:PRK06546  240 IQYDNPFDVGMSGLLGYGAAHEAMHEADLLILLGTDFPYDQFLPD---VRTAQVDIDPEHLGRRTRVDLAVHGDVAETIR 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 321 QLnsseTTILHP--DDGFL-KACQENVANWNRWM---TGKRElDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSAR 394
Cdd:PRK06546  317 AL----LPLVKEktDRRFLdRMLKKHARKLEKVVgayTRKVE-KHTPIHPEYVASILDELAADDAVFTVDTGMCNVWAAR 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 395 FLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYE 474
Cdd:PRK06546  392 YITPNGRRRVIGSFRHGSMANALPHAIGAQLADPGRQVISMSGDGGLSMLLGELLTVKLYDLPVKVVVFNNSTLGMVKLE 471
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586112881 475 QQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYVSDDA-PLPGKIVGQEAKGY 551
Cdd:PRK06546  472 MLVDGLPDFGTDHPPVDYAAIAAALGIHAVRVEDPKDVRGALREAFA-HPGPALVDVVTDPNAlSIPPTITGEQVKGF 548
acolac_lg TIGR00118
acetolactate synthase, large subunit, biosynthetic type; Two groups of proteins form ...
3-538 1.71e-86

acetolactate synthase, large subunit, biosynthetic type; Two groups of proteins form acetolactate from two molecules of pyruvate. The type of acetolactate synthase described in this model also catalyzes the formation of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, an early step in the branched chain amino acid biosynthesis; it is therefore also termed acetohydroxyacid synthase. In bacteria, this catalytic chain is associated with a smaller regulatory chain in an alpha2/beta2 heterotetramer. Acetolactate synthase is a thiamine pyrophosphate enzyme. In this type, FAD and Mg++ are also found. Several isozymes of this enzyme are found in E. coli K12, one of which contains a frameshift in the large subunit gene and is not expressed. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272915 [Multi-domain]  Cd Length: 558  Bit Score: 278.92  E-value: 1.71e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   3 QKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRkQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHI 82
Cdd:TIGR00118   1 MSGAEAIIESLKDEGVKTVFGYPGGAILPIYDALY-NDSGIEHILVRHEQGAAHAADGYARASGKVGVVLVTSGPGATNL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  83 LNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIP 161
Cdd:TIGR00118  80 VTGIATAYMDSIPMVVFTGQVPTSLIGSDAFQEADILGITMPITKHSFQVKSAEDIPRIIKEAFHIATTgRPGPVLVDLP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 162 DNLPEQRVSDHYISSAS--SFQltsPQIDDNRL--NTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTL 235
Cdd:TIGR00118 160 KDVTTAEIEYPYPEKVNlpGYR---PTVKGHPLqiKKAAELINLAKKPVILVGGGVIIAGAseELKELAERIQIPVTTTL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 236 PAKGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP--YTAYLPK--PgRAKSIQINTSASAIGKRYPADVGL 311
Cdd:TIGR00118 237 MGLGSFPEDHPLSLGMLGMHGTKTANLAVHECDLIIAVGARFDdrVTGNLAKfaP-NAKIIHIDIDPAEIGKNVRVDIPI 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 312 VADIKDVIKQLNSSETTILHPDDgflKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSW 391
Cdd:TIGR00118 316 VGDARNVLEELLKKLFELKERKE---SAWLEQINKWKKEYPLKMDYTEEGIKPQQVIEELSRVTKDEAIVTTDVGQHQMW 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 392 SARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFI 471
Cdd:TIGR00118 393 AAQFYPFRKPRRFITSGGLGTMGFGLPAAIGAKVAKPESTVICITGDGSFQMNLQELSTAVQYDIPVKILILNNRYLGMV 472
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1586112881 472 EYEQQA--AGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYVSDDAP 538
Cdd:TIGR00118 473 RQWQELfyEERYSHTHMGSLPDFVKLAEAYGIKGIRIEKPEELDEKLKEALS-SNEPVLLDVVVDKPEN 540
PRK08322 PRK08322
acetolactate synthase large subunit;
4-530 2.51e-84

acetolactate synthase large subunit;


Pssm-ID: 236239 [Multi-domain]  Cd Length: 547  Bit Score: 272.86  E-value: 2.51e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   4 KASEQLVDVLIDWHVKHVYGLPGD-SIDTtVDALRKQQdqIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHI 82
Cdd:PRK08322    2 KAADLFVKCLENEGVEYIFGIPGEeNLDL-LEALRDSS--IKLILTRHEQGAAFMAATYGRLTGKAGVCLSTLGPGATNL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  83 LNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAY-EKHGVAVLTIP 161
Cdd:PRK08322   79 VTGVAYAQLGGMPMVAITGQKPIKRSKQGSFQIVDVVAMMAPLTKWTRQIVSPDNIPEVVREAFRLAEeERPGAVHLELP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 162 DNLPEQRVSDHYISsASSFQLTSPqiDDNRLNTAAKLIRDSKKPLALVGLGA--KKAGSQVAAFLEQNHIPFISTLPAKG 239
Cdd:PRK08322  159 EDIAAEETDGKPLP-RSYSRRPYA--SPKAIERAAEAIQAAKNPLILIGAGAnrKTASKALTEFVDKTGIPFFTTQMGKG 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 240 IIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGtnYPYTAYLPK----PGRAKSIQINTSASAIGKRYPADVGLVADI 315
Cdd:PRK08322  236 VIPETHPLSLGTAGLSQGDYVHCAIEHADLIINVG--HDVIEKPPFfmnpNGDKKVIHINFLPAEVDPVYFPQVEVVGDI 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 316 KDVIKQLNSSETTILH-PDDGFLKACQENVANwnrwMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSAR 394
Cdd:PRK08322  314 ANSLWQLKERLADQPHwDFPRFLKIREAIEAH----LEEGADDDRFPMKPQRIVADLRKVMPDDDIVILDNGAYKIWFAR 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 395 FLnvsPTQK---FILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFI 471
Cdd:PRK08322  390 NY---RAYEpntCLLDNALATMGAGLPSAIAAKLVHPDRKVLAVCGDGGFMMNSQELETAVRLGLPLVVLILNDNAYGMI 466
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1586112881 472 EYEQQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLIN 530
Cdd:PRK08322  467 RWKQENMGFEDFGLDFGNPDFVKYAESYGAKGYRVESADDLLPTLEEALA-QPGVHVID 524
TPP_POX cd02014
Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; ...
361-539 8.14e-84

Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. It requires FAD in addition to TPP and a divalent cation as cofactors.


Pssm-ID: 238972 [Multi-domain]  Cd Length: 178  Bit Score: 259.00  E-value: 8.14e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 361 PVAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGA 440
Cdd:cd02014     1 PIHPERVAAELNKRAPDDAIFTIDVGNVTVWAARHLRMNGKQRFILSGLLATMGNGLPGAIAAKLAYPDRQVIALSGDGG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 441 FAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAY 520
Cdd:cd02014    81 FAMLMGDLITAVKYNLPVIVVVFNNSDLGFIKWEQEVMGQPEFGVDLPNPDFAKIAEAMGIKGIRVEDPDELEAALDEAL 160
                         170
                  ....*....|....*....
gi 1586112881 521 RvQNMPVLINAYVSDDAPL 539
Cdd:cd02014   161 A-ADGPVVIDVVTDPNEPP 178
ilvB CHL00099
acetohydroxyacid synthase large subunit
9-542 4.47e-75

acetohydroxyacid synthase large subunit


Pssm-ID: 214363 [Multi-domain]  Cd Length: 585  Bit Score: 249.62  E-value: 4.47e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   9 LVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDQiGFVQ---VRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:CHL00099   16 LIDSLVRHGVKHIFGYPGGAILPIYDELYAWEKK-GLIKhilVRHEQGAAHAADGYARSTGKVGVCFATSGPGATNLVTG 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAyeKHGV--AVLT-IPD 162
Cdd:CHL00099   95 IATAQMDSVPLLVITGQVGRAFIGTDAFQEVDIFGITLPIVKHSYVVRDARDISRIVAEAFYIA--KHGRpgPVLIdIPK 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 163 NLPEQRVSDH-YISSASSFQLT----SPQIDDNRLNTAAKLIRDSKKPLALVGLGA--KKAGSQVAAFLEQNHIPFISTL 235
Cdd:CHL00099  173 DVGLEKFDYYpPEPGNTIIKILgcrpIYKPTIKRIEQAAKLILQSSQPLLYVGGGAiiSDAHQEITELAELYKIPVTTTL 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 236 PAKGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP--YTAYLPK-PGRAKSIQINTSASAIGKRYPADVGLV 312
Cdd:CHL00099  253 MGKGIFDEDHPLCLGMLGMHGTAYANFAVSECDLLIALGARFDdrVTGKLDEfACNAQVIHIDIDPAEIGKNRIPQVAIV 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 313 ADIKDVIKQ-LNSSETTILHPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPhNTIYSIDVGTATSW 391
Cdd:CHL00099  333 GDVKKVLQElLELLKNSPNLLESEQTQAWRERINRWRKEYPLLIPKPSTSLSPQEVINEISQLAP-DAYFTTDVGQHQMW 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 392 SARFLNVSPtQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFI 471
Cdd:CHL00099  412 AAQFLKCKP-RKWLSSAGLGTMGYGLPAAIGAQIAHPNELVICISGDASFQMNLQELGTIAQYNLPIKIIIINNKWQGMV 490
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 472 EYEQQAAGQLNYQidLQDM-----DYAKFADAAGGVGITAKTSEEFKNALNRAYRVqNMPVLINAYVSDDA---PL--PG 541
Cdd:CHL00099  491 RQWQQAFYGERYS--HSNMeegapDFVKLAEAYGIKGLRIKSRKDLKSSLKEALDY-DGPVLIDCQVIEDEncyPMvaPG 567

                  .
gi 1586112881 542 K 542
Cdd:CHL00099  568 K 568
TPP_PYR_POX cd07039
Pyrimidine (PYR) binding domain of POX; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) ...
4-167 2.53e-74

Pyrimidine (PYR) binding domain of POX; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate oxidase (POX) subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. Lactobacillus plantarum POX is a homotetramer (dimer-of-homodimers), having two active sites per homodimer lying between PYR and PP domains of different subunits. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate.


Pssm-ID: 132922 [Multi-domain]  Cd Length: 164  Bit Score: 233.98  E-value: 2.53e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   4 KASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQqDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHIL 83
Cdd:cd07039     1 TVADVIVETLENWGVKRVYGIPGDSINGLMDALRRE-GKIEFIQVRHEEAAAFAASAEAKLTGKLGVCLGSSGPGAIHLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  84 NGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTIPDN 163
Cdd:cd07039    80 NGLYDAKRDRAPVLAIAGQVPTDELGTDYFQEVDLLALFKDVAVYNETVTSPEQLPELLDRAIRTAIAKRGVAVLILPGD 159

                  ....
gi 1586112881 164 LPEQ 167
Cdd:cd07039   160 VQDA 163
PRK06276 PRK06276
acetolactate synthase large subunit;
4-540 1.03e-73

acetolactate synthase large subunit;


Pssm-ID: 235766 [Multi-domain]  Cd Length: 586  Bit Score: 246.20  E-value: 1.03e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   4 KASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALrkQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHIL 83
Cdd:PRK06276    2 KGAEAIIKALEAEGVKIIFGYPGGALLPFYDAL--YDSDLIHILTRHEQAAAHAADGYARASGKVGVCVATSGPGATNLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  84 NGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPD 162
Cdd:PRK06276   80 TGIATAYADSSPVIALTGQVPTKLIGNDAFQEIDALGIFMPITKHNFQIKKPEEIPEIFRAAFEIAKTgRPGPVHIDLPK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 163 NLPEQRVS--DHYISSASSFQLTSPQIDDNRLNT--AAKLIRDSKKPLALVGLGAKKAGS-----QVAAFLEqnhIPFIS 233
Cdd:PRK06276  160 DVQEGELDleKYPIPAKIDLPGYKPTTFGHPLQIkkAAELIAEAERPVILAGGGVIISGAseeliELSELVK---IPVCT 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 234 TLPAKGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP------YTAYLPKpgrAKSIQINTSASAIGKRYPA 307
Cdd:PRK06276  237 TLMGKGAFPEDHPLALGMVGMHGTKAANYSVTESDVLIAIGCRFSdrttgdISSFAPN---AKIIHIDIDPAEIGKNVRV 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 308 DVGLVADIKDVIKQLNSsettilhpddgflKACQENVANWNRWMTGKREL----------DSKPVAPEALFNDINE---- 373
Cdd:PRK06276  314 DVPIVGDAKNVLRDLLA-------------ELMKKEIKNKSEWLERVKKLkkesiprmdfDDKPIKPQRVIKELMEvlre 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 374 -TAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAV 452
Cdd:PRK06276  381 iDPSKNTIITTDVGQNQMWMAHFFKTSAPRSFISSGGLGTMGFGFPAAIGAKVAKPDANVIAITGDGGFLMNSQELATIA 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 453 KYKLPLINIVLNNSKLAFI-EYEQQAAGQLNYQIDLQDM-DYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLIN 530
Cdd:PRK06276  461 EYDIPVVICIFDNRTLGMVyQWQNLYYGKRQSEVHLGETpDFVKLAESYGVKADRVEKPDEIKEALKEAIK-SGEPYLLD 539
                         570
                  ....*....|
gi 1586112881 531 AYVSDDAPLP 540
Cdd:PRK06276  540 IIIDPAEALP 549
PRK08527 PRK08527
acetolactate synthase large subunit;
1-533 1.11e-70

acetolactate synthase large subunit;


Pssm-ID: 181458 [Multi-domain]  Cd Length: 563  Bit Score: 237.30  E-value: 1.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQqDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAI 80
Cdd:PRK08527    1 KKLSGSQMVCEALKEEGVKVVFGYPGGAILNIYDEIYKQ-NYFKHILTRHEQAAVHAADGYARASGKVGVAIVTSGPGFT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLT 159
Cdd:PRK08527   80 NAVTGLATAYMDSIPLVLISGQVPNSLIGTDAFQEIDAVGISRPCVKHNYLVKSIEELPRILKEAFYIARSgRPGPVHID 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 160 IPDNLPEQrVSDHYISSASSFQLTSPQIDDN--RLNTAAKLIRDSKKPLALVGLGA--KKAGSQVAAFLEQNHIPFISTL 235
Cdd:PRK08527  160 IPKDVTAT-LGEFEYPKEISLKTYKPTYKGNsrQIKKAAEAIKEAKKPLFYLGGGAilSNASEEIRELVKKTGIPAVETL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 236 PAKGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP--YTAYLPKPGR-AKSIQINTSASAIGKRYPADVGLV 312
Cdd:PRK08527  239 MARGVLRSDDPLLLGMLGMHGSYAANMAMSECDLLISLGARFDdrVTGKLSEFAKhAKIIHVDIDPSSISKIVNADYPIV 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 313 ADIKDVIKQLNSsETTILHPDDgfLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWS 392
Cdd:PRK08527  319 GDLKNVLKEMLE-ELKEENPTT--YKEWREILKRYNELHPLSYEDSDEVLKPQWVIERVGELLGDDAIISTDVGQHQMWV 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 393 ARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIE 472
Cdd:PRK08527  396 AQFYPFNYPRQLATSGGLGTMGYGLPAALGAKLAVPDKVVINFTGDGSILMNIQELMTAVEYKIPVINIILNNNFLGMVR 475
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586112881 473 ------YEQQAAgqlNYQIDLQDmDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYV 533
Cdd:PRK08527  476 qwqtffYEERYS---ETDLSTQP-DFVKLAESFGGIGFRVTTKEEFDKALKEALE-SDKVALIDVKI 537
PRK06048 PRK06048
acetolactate synthase large subunit;
5-537 1.02e-69

acetolactate synthase large subunit;


Pssm-ID: 180368 [Multi-domain]  Cd Length: 561  Bit Score: 234.67  E-value: 1.02e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   5 ASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQdqIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILN 84
Cdd:PRK06048   10 GARAIIKCLEKEGVEVIFGYPGGAIIPVYDELYDSD--LRHILVRHEQAAAHAADGYARATGKVGVCVATSGPGATNLVT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  85 GLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDN 163
Cdd:PRK06048   88 GIATAYMDSVPIVALTGQVPRSMIGNDAFQEADITGITMPITKHNYLVQDAKDLPRIIKEAFHIASTgRPGPVLIDLPKD 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 164 LPEQRVSDHYISSASsFQLTSPQIDDN--RLNTAAKLIRDSKKPLALVGLG--AKKAGSQVAAFLEQNHIPFISTLPAKG 239
Cdd:PRK06048  168 VTTAEIDFDYPDKVE-LRGYKPTYKGNpqQIKRAAELIMKAERPIIYAGGGviSSNASEELVELAETIPAPVTTTLMGIG 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 240 IIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNY------PYTAYLPKpgrAKSIQINTSASAIGKRYPADVGLVA 313
Cdd:PRK06048  247 AIPTEHPLSLGMLGMHGTKYANYAIQESDLIIAVGARFddrvtgKLASFAPN---AKIIHIDIDPAEISKNVKVDVPIVG 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 314 DIKDVIKQLNSsettilhpddgFLKACQ-----ENVANWNRWMTGKRELDSKPVAPEALFNDINETAPhNTIYSIDVGTA 388
Cdd:PRK06048  324 DAKQVLKSLIK-----------YVQYCDrkewlDKINQWKKEYPLKYKEREDVIKPQYVIEQIYELCP-DAIIVTEVGQH 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 389 TSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKL 468
Cdd:PRK06048  392 QMWAAQYFKYKYPRTFITSGGLGTMGYGFPAAIGAKVGKPDKTVIDIAGDGSFQMNSQELATAVQNDIPVIVAILNNGYL 471
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1586112881 469 AFIEYEQQAAGQLNY-QIDLQD-MDYAKFADAAGGVGITAKTSEEFKNALNRAYRVqNMPVLINAYVSDDA 537
Cdd:PRK06048  472 GMVRQWQELFYDKRYsHTCIKGsVDFVKLAEAYGALGLRVEKPSEVRPAIEEAVAS-DRPVVIDFIVECEE 541
PRK08199 PRK08199
thiamine pyrophosphate protein; Validated
1-529 3.31e-69

thiamine pyrophosphate protein; Validated


Pssm-ID: 181285 [Multi-domain]  Cd Length: 557  Bit Score: 233.23  E-value: 3.31e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDqIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAI 80
Cdd:PRK08199    6 RARTGGQILVDALRANGVERVFCVPGESYLAVLDALHDETD-IRVIVCRQEGGAAMMAEAYGKLTGRPGICFVTRGPGAT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLT 159
Cdd:PRK08199   85 NASIGVHTAFQDSTPMILFVGQVARDFREREAFQEIDYRRMFGPMAKWVAEIDDAARIPELVSRAFHVATSgRPGPVVLA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 160 IPDNLPEQRVSdhyISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAK--KAGSQVAAFLEQNHIPFISTLPA 237
Cdd:PRK08199  165 LPEDVLSETAE---VPDAPPYRRVAAAPGAADLARLAELLARAERPLVILGGSGWteAAVADLRAFAERWGLPVACAFRR 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 238 KGIIGDNHPNSLGNVGkLGTKPAY-EAMQNTDLLLMFGTNY---PYTAY----LPKPgRAKSIQINTSASAIGKRYPADV 309
Cdd:PRK08199  242 QDLFDNRHPNYAGDLG-LGINPALaARIREADLVLAVGTRLgevTTQGYtlldIPVP-RQTLVHVHPDAEELGRVYRPDL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 310 GLVADIKDVIKQLNSsettiLHPDDgflkacqenVANWNRWMTGKRE--LDSKPVAP-------EALFNDINETAPHNTI 380
Cdd:PRK08199  320 AIVADPAAFAAALAA-----LEPPA---------SPAWAEWTAAAHAdyLAWSAPLPgpgavqlGEVMAWLRERLPADAI 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 381 YSIDVGTATSWSARF--LNVSPTQkfiLSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPL 458
Cdd:PRK08199  386 ITNGAGNYATWLHRFfrFRRYRTQ---LAPTSGSMGYGLPAAIAAKLLFPERTVVAFAGDGCFLMNGQELATAVQYGLPI 462
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586112881 459 INIVLNNSKLAFI------EYEQQAAGqlnyqIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAyRVQNMPVLI 529
Cdd:PRK08199  463 IVIVVNNGMYGTIrmhqerEYPGRVSG-----TDLTNPDFAALARAYGGHGETVERTEDFAPAFERA-LASGKPALI 533
PRK08978 PRK08978
acetolactate synthase 2 catalytic subunit; Reviewed
9-518 2.05e-68

acetolactate synthase 2 catalytic subunit; Reviewed


Pssm-ID: 181601 [Multi-domain]  Cd Length: 548  Bit Score: 230.92  E-value: 2.05e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   9 LVDVLIDWHVKHVYGLPGDSIDTTVDALrkQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNGLYD 88
Cdd:PRK08978    7 VVHALRAQGVDTVFGYPGGAIMPVYDAL--YDGGVEHLLCRHEQGAAMAAIGYARATGKVGVCIATSGPGATNLITGLAD 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  89 AKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDN--LP 165
Cdd:PRK08978   85 ALLDSVPVVAITGQVSSPLIGTDAFQEIDVLGLSLACTKHSFLVQSLEELPEIMAEAFEIASSgRPGPVLVDIPKDiqLA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 166 EQRVSDHYISSASSfqltsPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTLPAKGIIGD 243
Cdd:PRK08978  165 EGELEPHLTTVENE-----PAFPAAELEQARALLAQAKKPVLYVGGGVGMAGAvpALREFLAATGMPAVATLKGLGAVEA 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 244 NHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNY------PYTAYLPKpgrAKSIQINTSASAIGKRYPADVGLVADIKD 317
Cdd:PRK08978  240 DHPYYLGMLGMHGTKAANLAVQECDLLIAVGARFddrvtgKLNTFAPH---AKVIHLDIDPAEINKLRQAHVALQGDLNA 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 318 VIKQLnsseTTILHPDdgflkACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSARFLN 397
Cdd:PRK08978  317 LLPAL----QQPLNID-----AWRQHCAQLRAEHAWRYDHPGEAIYAPALLKQLSDRKPADTVVTTDVGQHQMWVAQHMR 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 398 VSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQA 477
Cdd:PRK08978  388 FTRPENFITSSGLGTMGFGLPAAIGAQVARPDDTVICVSGDGSFMMNVQELGTIKRKQLPVKIVLLDNQRLGMVRQWQQL 467
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1586112881 478 AGQLNY-QIDLQDM-DYAKFADAAGGVGITAKTSEEFKNALNR 518
Cdd:PRK08978  468 FFDERYsETDLSDNpDFVMLASAFGIPGQTITRKDQVEAALDT 510
PRK07789 PRK07789
acetolactate synthase 1 catalytic subunit; Validated
6-537 2.34e-65

acetolactate synthase 1 catalytic subunit; Validated


Pssm-ID: 236098 [Multi-domain]  Cd Length: 612  Bit Score: 224.48  E-value: 2.34e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   6 SEQLVDVLIDWHVKHVYGLPGDSIDTTVDALrKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK07789   34 AQAVVRSLEELGVDVVFGIPGGAILPVYDPL-FDSTKVRHVLVRHEQGAGHAAEGYAQATGRVGVCMATSGPGATNLVTP 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLT-IP-DN 163
Cdd:PRK07789  113 IADANMDSVPVVAITGQVGRGLIGTDAFQEADIVGITMPITKHNFLVTDADDIPRVIAEAFHIASTGRPGPVLVdIPkDA 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 164 LPEQRvsdhYISSASSFQL------TSP---QIDDnrlntAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFI 232
Cdd:PRK07789  193 LQAQT----TFSWPPRMDLpgyrpvTKPhgkQIRE-----AAKLIAAARRPVLYVGGGVIRAEAsaELRELAELTGIPVV 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 233 STLPAKGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP--YTAYLPK--PGrAKSIQINTSASAIGKRYPAD 308
Cdd:PRK07789  264 TTLMARGAFPDSHPQHLGMPGMHGTVAAVAALQRSDLLIALGARFDdrVTGKLDSfaPD-AKVIHADIDPAEIGKNRHAD 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 309 VGLVADIKDVIKQLNS---SETTILHPDDgflkacqenVANWNRWMTGKREL--------DSKPVAPEALFNDINETAPH 377
Cdd:PRK07789  343 VPIVGDVKEVIAELIAalrAEHAAGGKPD---------LTAWWAYLDGWRETyplgydepSDGSLAPQYVIERLGEIAGP 413
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 378 NTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLP 457
Cdd:PRK07789  414 DAIYVAGVGQHQMWAAQFIDYEKPRTWLNSGGLGTMGYAVPAAMGAKVGRPDKEVWAIDGDGCFQMTNQELATCAIEGIP 493
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 458 LINIVLNNSKLAFIE------YEQQAAgqlnyQIDLQDM-----DYAKFADAAGGVGITAKTSEEFKNALNRAYRVQNMP 526
Cdd:PRK07789  494 IKVALINNGNLGMVRqwqtlfYEERYS-----NTDLHTHshripDFVKLAEAYGCVGLRCEREEDVDAVIEKARAINDRP 568
                         570
                  ....*....|.
gi 1586112881 527 VLINAYVSDDA 537
Cdd:PRK07789  569 VVIDFVVGKDA 579
PRK08266 PRK08266
hypothetical protein; Provisional
7-536 4.05e-65

hypothetical protein; Provisional


Pssm-ID: 181337 [Multi-domain]  Cd Length: 542  Bit Score: 222.19  E-value: 4.05e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   7 EQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNGL 86
Cdd:PRK08266    8 EAIVAGLVAHGVDTVFGLPGAQLYWLFDALYKAGDRIRVIHTRHEQAAGYMAFGYARSTGRPGVCSVVPGPGVLNAGAAL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  87 YDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNK---LISATDNLAEIVDEAIRTAYEKH-GVAVLTIPD 162
Cdd:PRK08266   88 LTAYGCNSPVLCLTGQIPSALIGKGRGHLHEMPDQLATLRSFTKwaeRIEHPSEAPALVAEAFQQMLSGRpRPVALEMPW 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 163 NLPEQRVSDHYISSASsfQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFISTLPAKGIIG 242
Cdd:PRK08266  168 DVFGQRAPVAAAPPLR--PAPPPAPDPDAIAAAAALIAAAKNPMIFVGGGAAGAGEEIRELAEMLQAPVVAFRSGRGIVS 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 243 DNHPNSLGNVGklgtkpAYEAMQNTDLLLMFGTNY--PYTAYLPKPGRAKSIQINTSASAIGkRYPADVGLVADIKDVik 320
Cdd:PRK08266  246 DRHPLGLNFAA------AYELWPQTDVVIGIGSRLelPTFRWPWRPDGLKVIRIDIDPTEMR-RLKPDVAIVADAKAG-- 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 321 qlnssettilhpddgfLKACQENVANWNRWMTGKRE----------LDSKPVAPEALF-NDINETAPHNTIY---SIDVG 386
Cdd:PRK08266  317 ----------------TAALLDALSKAGSKRPSRRAelrelkaaarQRIQAVQPQASYlRAIREALPDDGIFvdeLSQVG 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 387 TAtSWSArFLNVSPTQkFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNS 466
Cdd:PRK08266  381 FA-SWFA-FPVYAPRT-FVTCGYQGTLGYGFPTALGAKVANPDRPVVSITGDGGFMFGVQELATAVQHNIGVVTVVFNNN 457
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1586112881 467 KLAFIEYEQ-QAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYVSDD 536
Cdd:PRK08266  458 AYGNVRRDQkRRFGGRVVASDLVNPDFVKLAESFGVAAFRVDSPEELRAALEAALA-HGGPVLIEVPVPRG 527
acolac_catab TIGR02418
acetolactate synthase, catabolic; Acetolactate synthase (EC 2.2.1.6) combines two molecules of ...
5-529 2.25e-64

acetolactate synthase, catabolic; Acetolactate synthase (EC 2.2.1.6) combines two molecules of pyruvate to yield 2-acetolactate with the release of CO2. This reaction may be involved in either valine biosynthesis (biosynthetic) or conversion of pyruvate to acetoin and possibly to 2,3-butanediol (catabolic). The biosynthetic type, described by TIGR00118, is also capable of forming acetohydroxybutyrate from pyruvate and 2-oxobutyrate for isoleucine biosynthesis. The family described here, part of the same larger family of thiamine pyrophosphate-dependent enzymes (pfam00205, pfam02776) is the catabolic form, generally found associated with in species with acetolactate decarboxylase and usually found in the same operon. The model may not encompass all catabolic acetolactate synthases, but rather one particular clade in the larger TPP-dependent enzyme family. [Energy metabolism, Fermentation]


Pssm-ID: 131471 [Multi-domain]  Cd Length: 539  Bit Score: 220.01  E-value: 2.25e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   5 ASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALrkQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILN 84
Cdd:TIGR02418   1 GADLVVDQLENQGVRYVFGIPGAKIDRVFDAL--EDKGIELIVVRHEQNAAFMAQAVGRITGKPGVALVTSGPGCSNLVT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  85 GLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDN 163
Cdd:TIGR02418  79 GLATANSEGDPVVAIGGQVKRADLLKLTHQSMDNVALFRPITKYSAEVQDPDALSEVVANAFRAAESgKPGAAFVSLPQD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 164 LPEQRVSDHYISSASSFQLTSPQIDDnrLNTAAKLIRDSKKPLALVGLGAKKAGSQVA--AFLEQNHIPFISTLPAKGII 241
Cdd:TIGR02418 159 VVDSPVSVKAIPASYAPKLGAAPDDA--IDEVAEAIQNAKLPVLLLGLRASSPETTEAvrRLLKKTQLPVVETFQGAGAV 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 242 G-DNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGtnYPYTAYLP----KPGRAKSIQINTSASAIGKRYPADVGLVADIK 316
Cdd:TIGR02418 237 SrELEDHFFGRVGLFRNQPGDRLLKQADLVITIG--YDPIEYEPrnwnSENDATIVHIDVEPAQIDNNYQPDLELVGDIA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 317 DVIKQLNSS-ETTILHPDD-GFLKACQENVANWNRWmtgKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSAR 394
Cdd:TIGR02418 315 STLDLLAERiPGYELPPDAlAILEDLKQQREALDRV---PATLKQAHLHPLEIIKAMQAIVTDDVTVTVDMGSHYIWMAR 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 395 FLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYE 474
Cdd:TIGR02418 392 YFRSYRARHLLISNGMQTLGVALPWAIGAALVRPNTKVVSVSGDGGFLFSSMELETAVRLKLNIVHIIWNDNGYNMVEFQ 471
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1586112881 475 QQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRVqNMPVLI 529
Cdd:TIGR02418 472 EEMKYQRSSGVDFGPIDFVKYAESFGAKGLRVESPDQLEPTLRQAMEV-EGPVVV 525
PRK07418 PRK07418
acetolactate synthase large subunit;
9-542 4.81e-64

acetolactate synthase large subunit;


Pssm-ID: 236014 [Multi-domain]  Cd Length: 616  Bit Score: 221.08  E-value: 4.81e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   9 LVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDQiGFVQ---VRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK07418   25 LMDSLKRHGVKHIFGYPGGAILPIYDELYKAEAE-GWLKhilVRHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTG 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDNL 164
Cdd:PRK07418  104 IATAQMDSVPMVVITGQVPRPAIGTDAFQETDIFGITLPIVKHSYVVRDPSDMARIVAEAFHIASSgRPGPVLIDIPKDV 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 pEQRVSDHYISSASSFQLT----SPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTLPAK 238
Cdd:PRK07418  184 -GQEEFDYVPVEPGSVKPPgyrpTVKGNPRQINAALKLIEEAERPLLYVGGGAISAGAhaELKELAERFQIPVTTTLMGK 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 239 GIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP--YTAYLPK-PGRAKSIQINTSASAIGKRYPADVGLVADI 315
Cdd:PRK07418  263 GAFDEHHPLSVGMLGMHGTAYANFAVTECDLLIAVGARFDdrVTGKLDEfASRAKVIHIDIDPAEVGKNRRPDVPIVGDV 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 316 KDVIKQLN--SSEttilhpddgflKACQENVANW----NRWmtgKREL------DSKPVAPEALFNDINETAPHnTIYSI 383
Cdd:PRK07418  343 RKVLVKLLerSLE-----------PTTPPRTQAWleriNRW---KQDYplvvppYEGEIYPQEVLLAVRDLAPD-AYYTT 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 384 DVGTATSWSARFLNVSPTQkFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVL 463
Cdd:PRK07418  408 DVGQHQMWAAQFLRNGPRR-WISSAGLGTMGFGMPAAMGVKVALPDEEVICIAGDASFLMNIQELGTLAQYGINVKTVII 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 464 NNSKLAFIEYEQQAAGQLNYQIdlQDM-----DYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYVSDDA- 537
Cdd:PRK07418  487 NNGWQGMVRQWQESFYGERYSA--SNMepgmpDFVKLAEAFGVKGMVISERDQLKDAIAEALA-HDGPVLIDVHVRRDEn 563

                  ....*....
gi 1586112881 538 --PL--PGK 542
Cdd:PRK07418  564 cyPMvpPGK 572
PRK06456 PRK06456
acetolactate synthase large subunit;
9-570 1.83e-62

acetolactate synthase large subunit;


Pssm-ID: 180569 [Multi-domain]  Cd Length: 572  Bit Score: 215.86  E-value: 1.83e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   9 LVDVLIDWHVKHVYGLPGDSIDTTVDALRK--QQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNGL 86
Cdd:PRK06456    8 LVDSLKREGVKVIFGIPGLSNMQIYDAFVEdlANGELRHVLMRHEQAAAHAADGYARASGVPGVCTATSGPGTTNLVTGL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  87 YDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDNLP 165
Cdd:PRK06456   88 ITAYWDSSPVIAITGQVPRSVMGKMAFQEADAMGVFENVTKYVIGIKRIDEIPQWIKNAFYIATTgRPGPVVIDIPRDIF 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 166 EQRVSD------HYISSASSFQLTspqIDDNRLNTAAKLIRDSKKPLALVGLGA--KKAGSQVAAFLEQNHIPFISTLPA 237
Cdd:PRK06456  168 YEKMEEikwpekPLVKGYRDFPTR---IDRLALKKAAEILINAERPIILVGTGVvwSNATPEVLELAELLHIPIVSTFPG 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 238 KGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFG---TNYPYTAYLP-KPGRAKSIQINTSASAIGKRYPADVGLVA 313
Cdd:PRK06456  245 KTAIPHDHPLYFGPMGYYGRAEASMAALESDAMLVVGarfSDRTFTSYDEmVETRKKFIMVNIDPTDGEKAIKVDVGIYG 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 314 DIKDVIKQL--NSSETTILHPDDGFLKACQENVANWNRWMTGKrelDSKPVAPEALFNDINETAPHNTIYSIDVGTATSW 391
Cdd:PRK06456  325 NAKIILRELikAITELGQKRDRSAWLKRVKEYKEYYSQFYYTE---ENGKLKPWKIMKTIRQALPRDAIVTTGVGQHQMW 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 392 SARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFI 471
Cdd:PRK06456  402 AEVFWEVLEPRTFLTSSGMGTMGFGLPAAMGAKLARPDKVVVDLDGDGSFLMTGTNLATAVDEHIPVISVIFDNRTLGLV 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 472 EYEQQAAgqLNYQIDLQDM----DYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYVSddaplpgkivgqe 547
Cdd:PRK06456  482 RQVQDLF--FGKRIVGVDYgpspDFVKLAEAFGALGFNVTTYEDIEKSLKSAIK-EDIPAVIRVPVD------------- 545
                         570       580
                  ....*....|....*....|...
gi 1586112881 548 akgymkfgsqylKEEKKIPELPP 570
Cdd:PRK06456  546 ------------KEELALPTLPP 556
PRK08617 PRK08617
acetolactate synthase AlsS;
3-530 2.70e-60

acetolactate synthase AlsS;


Pssm-ID: 236312 [Multi-domain]  Cd Length: 552  Bit Score: 209.33  E-value: 2.70e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   3 QKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALrkQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHI 82
Cdd:PRK08617    5 KYGADLVVDSLINQGVKYVFGIPGAKIDRVFDAL--EDSGPELIVTRHEQNAAFMAAAIGRLTGKPGVVLVTSGPGVSNL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  83 LNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIP 161
Cdd:PRK08617   83 ATGLVTATAEGDPVVAIGGQVKRADRLKRTHQSMDNVALFRPITKYSAEVQDPDNLSEVLANAFRAAESgRPGAAFVSLP 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 162 DNLPEQRVSDHYISSASSFQLTSPQIDDnrLNTAAKLIRDSKKPLALVGLGA--KKAGSQVAAFLEQNHIPFISTLPAKG 239
Cdd:PRK08617  163 QDVVDAPVTSKAIAPLSKPKLGPASPED--INYLAELIKNAKLPVLLLGMRAssPEVTAAIRRLLERTNLPVVETFQAAG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 240 IIGDNH-PNSLGNVGKLGTKPAYEAMQNTDLLLMFGtnYPYTAYLP----KPGRAKSIQINTSASAIGKRYPADVGLVAD 314
Cdd:PRK08617  241 VISRELeDHFFGRVGLFRNQPGDELLKKADLVITIG--YDPIEYEPrnwnSEGDATIIHIDVLPAEIDNYYQPERELIGD 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 315 IKDVIKQLNSSETTILHPDDG--FLKACQENVanwNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWS 392
Cdd:PRK08617  319 IAATLDLLAEKLDGLSLSPQSleILEELRAQL---EELAERPARLEEGAVHPLRIIRALQDIVTDDTTVTVDVGSHYIWM 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 393 ARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIE 472
Cdd:PRK08617  396 ARYFRSYEPRHLLFSNGMQTLGVALPWAIAAALVRPGKKVVSVSGDGGFLFSAMELETAVRLKLNIVHIIWNDGHYNMVE 475
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586112881 473 YEQqaagQLNYQ----IDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRVQNmPVLIN 530
Cdd:PRK08617  476 FQE----EMKYGrssgVDFGPVDFVKYAESFGAKGLRVTSPDELEPVLREALATDG-PVVID 532
PRK09107 PRK09107
acetolactate synthase 3 catalytic subunit; Validated
6-533 6.84e-58

acetolactate synthase 3 catalytic subunit; Validated


Pssm-ID: 236380 [Multi-domain]  Cd Length: 595  Bit Score: 203.79  E-value: 6.84e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   6 SEQLVDVLIDWHVKHVYGLPGDSIDTTVDALrKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK09107   14 AEMVVQALKDQGVEHIFGYPGGAVLPIYDEI-FQQDDIQHILVRHEQGAGHAAEGYARSTGKPGVVLVTSGPGATNAVTP 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDNL 164
Cdd:PRK09107   93 LQDALMDSIPLVCITGQVPTHLIGSDAFQECDTVGITRPCTKHNWLVKDVNDLARVIHEAFHVATSgRPGPVVVDIPKDV 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 peQRVSDHYISSASSFQLTS--PQI--DDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFL----EQNHIPFISTL- 235
Cdd:PRK09107  173 --QFATGTYTPPQKAPVHVSyqPKVkgDAEAITEAVELLANAKRPVIYSGGGVINSGPEASRLLrelvELTGFPITSTLm 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 236 -----PAKGiigdnhPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP------YTAYLPKpgrAKSIQINTSASAIGKR 304
Cdd:PRK09107  251 glgayPASG------KNWLGMLGMHGTYEANMAMHDCDVMLCVGARFDdritgrLDAFSPN---SKKIHIDIDPSSINKN 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 305 YPADVGLVADI----KDVIKQLNSSETTilhPDDGFLKACQENVANWNrwmtGKRELDSKP----VAPEALFNDINE-TA 375
Cdd:PRK09107  322 VRVDVPIIGDVghvlEDMLRLWKARGKK---PDKEALADWWGQIARWR----ARNSLAYTPsddvIMPQYAIQRLYElTK 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 376 PHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYK 455
Cdd:PRK09107  395 GRDTYITTEVGQHQMWAAQFFGFEEPNRWMTSGGLGTMGYGLPAALGVQIAHPDALVIDIAGDASIQMCIQEMSTAVQYN 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 456 LPLINIVLNNSKLAFIEYEQQAAGQLNYQIDLQDM--DYAKFADAAGGVGITAKTSEEFKNALNRAYRVqNMPVLINAYV 533
Cdd:PRK09107  475 LPVKIFILNNQYMGMVRQWQQLLHGNRLSHSYTEAmpDFVKLAEAYGAVGIRCEKPGDLDDAIQEMIDV-DKPVIFDCRV 553
PRK06965 PRK06965
acetolactate synthase 3 catalytic subunit; Validated
6-530 8.93e-57

acetolactate synthase 3 catalytic subunit; Validated


Pssm-ID: 180780 [Multi-domain]  Cd Length: 587  Bit Score: 200.80  E-value: 8.93e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   6 SEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQqDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK06965   24 AEILMKALAAEGVEFIWGYPGGAVLYIYDELYKQ-DKIQHVLVRHEQAAVHAADGYARATGKVGVALVTSGPGVTNAVTG 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDNL 164
Cdd:PRK06965  103 IATAYMDSIPMVVISGQVPTAAIGQDAFQECDTVGITRPIVKHNFLVKDVRDLAETVKKAFYIARTgRPGPVVVDIPKDV 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 PEQRVSDHYISSAsSFQLTSP--QIDDNRLNTAAKLIRDSKKPLALVGLGA--KKAGSQVAAFLEQNHIPFISTLPAKGI 240
Cdd:PRK06965  183 SKTPCEYEYPKSV-EMRSYNPvtKGHSGQIRKAVSLLLSAKRPYIYTGGGVilANASRELRQLADLLGYPVTNTLMGLGA 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 241 IGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGT--------NYPYTAYLPKpgraKSIQINTSASAIGKRYPADVGLV 312
Cdd:PRK06965  262 YPASDKKFLGMLGMHGTYEANMAMQHCDVLIAIGArfddrvigNPAHFASRPR----KIIHIDIDPSSISKRVKVDIPIV 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 313 ADIKDVIKQLNSS-ETTILHPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSW 391
Cdd:PRK06965  338 GDVKEVLKELIEQlQTAEHGPDADALAQWWKQIEGWRSRDCLKYDRESEIIKPQYVVEKLWELTDGDAFVCSDVGQHQMW 417
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 392 SARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFI 471
Cdd:PRK06965  418 AAQFYRFNEPRRWINSGGLGTMGVGLPYAMGIKMAHPDDDVVCITGEGSIQMCIQELSTCLQYDTPVKIISLNNRYLGMV 497
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1586112881 472 EYEQQAAGQLNYQIDLQDM--DYAKFADAAGGVGITAKTSEEFKNALNRAYRVQNMPVLIN 530
Cdd:PRK06965  498 RQWQEIEYSKRYSHSYMDAlpDFVKLAEAYGHVGMRIEKTSDVEPALREALRLKDRTVFLD 558
PRK08979 PRK08979
acetolactate synthase 3 large subunit;
6-535 1.07e-56

acetolactate synthase 3 large subunit;


Pssm-ID: 181602 [Multi-domain]  Cd Length: 572  Bit Score: 200.05  E-value: 1.07e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   6 SEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDqIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK08979    7 ASMIVRSLIDEGVKHIFGYPGGSVLDIYDALHEKSG-IEHILVRHEQAAVHMADGYARATGKVGVVLVTSGPGATNTITG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIP-DN 163
Cdd:PRK08979   86 IATAYMDSIPMVVLSGQVPSNLIGNDAFQECDMIGISRPVVKHSFLVKDAEDIPEIIKKAFYIASTgRPGPVVIDLPkDC 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 164 LPEQRVSDHYISSASSFQLTSPQIDDNR--LNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTLPAKG 239
Cdd:PRK08979  166 LNPAILHPYEYPESIKMRSYNPTTSGHKgqIKRGLQALLAAKKPVLYVGGGAIISGAdkQILQLAEKLNLPVVSTLMGLG 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 240 IIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFG------TNYPYTAYLPKpgrAKSIQINTSASAIGKRYPADVGLV- 312
Cdd:PRK08979  246 AFPGTHKNSLGMLGMHGRYEANMAMHNADLIFGIGvrfddrTTNNLEKYCPN---ATILHIDIDPSSISKTVRVDIPIVg 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 313 -ADI--KDVIKQLNSSETTilhPDDGFLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTAT 389
Cdd:PRK08979  323 sADKvlDSMLALLDESGET---NDEAAIASWWNEIEVWRSRNCLAYDKSSERIKPQQVIETLYKLTNGDAYVASDVGQHQ 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 390 SWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLA 469
Cdd:PRK08979  400 MFAALYYPFDKPRRWINSGGLGTMGFGLPAAMGVKFAMPDETVVCVTGDGSIQMNIQELSTALQYDIPVKIINLNNRFLG 479
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586112881 470 FIEYEQQAAGQLNYQIDLQDM--DYAKFADAAGGVGITAKTSEEFKNALNRAYRVQNMPVLINAYVSD 535
Cdd:PRK08979  480 MVKQWQDMIYQGRHSHSYMDSvpDFAKIAEAYGHVGIRISDPDELESGLEKALAMKDRLVFVDINVDE 547
PRK07282 PRK07282
acetolactate synthase large subunit;
6-477 4.12e-56

acetolactate synthase large subunit;


Pssm-ID: 180919 [Multi-domain]  Cd Length: 566  Bit Score: 198.51  E-value: 4.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   6 SEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQqDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK07282   13 SDLVLETLRDLGVDTIFGYPGGAVLPLYDAIYNF-EGIRHILARHEQGALHEAEGYAKSTGKLGVAVVTSGPGATNAITG 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDNL 164
Cdd:PRK07282   92 IADAMSDSVPLLVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQIRETADIPRIITEAVHIATTgRPGPVVIDLPKDV 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 PEQRVSDHYISSAS--SFQLTSpQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTLPAKGI 240
Cdd:PRK07282  172 SALETDFIYDPEVNlpSYQPTL-EPNDMQIKKILKQLSKAKKPVILAGGGINYAEAatELNAFAERYQIPVVTTLLGQGT 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 241 IGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNY-------PYTaYLPKpgrAKSIQINTSASAIGKRYPADVGLVA 313
Cdd:PRK07282  251 IATSHPLFLGMGGMHGSYAANIAMTEADFMINIGSRFddrltgnPKT-FAKN---AKVAHIDIDPAEIGKIIKTDIPVVG 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 314 DIKDVIKQLNSSETTilhpDDGFLKACQENVANWNRWMTgkRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSA 393
Cdd:PRK07282  327 DAKKALQMLLAEPTV----HNNTEKWIEKVTKDKNRVRS--YDKKERVVQPQAVIERIGELTNGDAIVVTDVGQHQMWAA 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 394 RFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEY 473
Cdd:PRK07282  401 QYYPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVILFVGDGGFQMTNQELAILNIYKVPIKVVMLNNHSLGMVRQ 480

                  ....
gi 1586112881 474 EQQA 477
Cdd:PRK07282  481 WQES 484
PRK06882 PRK06882
acetolactate synthase 3 large subunit;
6-533 6.52e-55

acetolactate synthase 3 large subunit;


Pssm-ID: 168717 [Multi-domain]  Cd Length: 574  Bit Score: 195.13  E-value: 6.52e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   6 SEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQqDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK06882    7 AEMVVQSLRDEGVEYVFGYPGGSVLDIYDAIHTL-GGIEHVLVRHEQAAVHMADGYARSTGKVGCVLVTSGPGATNAITG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDNL 164
Cdd:PRK06882   86 IATAYTDSVPLVILSGQVPSNLIGTDAFQECDMLGISRPVVKHSFIVKNAEDIPSTIKKAFYIASTgRPGPVVIDIPKDM 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 --PEQRVSDHYISSASsFQLTSPQIDDNR--LNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTLPAK 238
Cdd:PRK06882  166 vnPANKFTYEYPEEVS-LRSYNPTVQGHKgqIKKALKALLVAKKPVLFVGGGVITAECseQLTQFAQKLNLPVTSSLMGL 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 239 GIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFG------TNYPYTAYLPkpgRAKSIQINTSASAIGKRYPADVGLV 312
Cdd:PRK06882  245 GAYPSTDKQFLGMLGMHGTYEANNAMHESDLILGIGvrfddrTTNNLAKYCP---NAKVIHIDIDPTSISKNVPAYIPIV 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 313 ADIKDVIKQLNSsettiLHPDDGFLKAcQENVANW----NRWMTGK---RELDSKPVAPEALFNDINETAPHNTIYSIDV 385
Cdd:PRK06882  322 GSAKNVLEEFLS-----LLEEENLAKS-QTDLTAWwqqiNEWKAKKcleFDRTSDVIKPQQVVEAIYRLTNGDAYVASDV 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 386 GTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNN 465
Cdd:PRK06882  396 GQHQMFAALHYPFDKPRRWINSGGAGTMGFGLPAAIGVKFAHPEATVVCVTGDGSIQMNIQELSTAKQYDIPVVIVSLNN 475
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1586112881 466 SKLAFIEYEQQA--AGQlNYQIDLQDM-DYAKFADAAGGVGITAKTSEEFKNALNRAYRVQNMPVLINAYV 533
Cdd:PRK06882  476 RFLGMVKQWQDLiySGR-HSQVYMNSLpDFAKLAEAYGHVGIQIDTPDELEEKLTQAFSIKDKLVFVDVNV 545
PRK06725 PRK06725
acetolactate synthase large subunit;
6-535 1.20e-54

acetolactate synthase large subunit;


Pssm-ID: 180672 [Multi-domain]  Cd Length: 570  Bit Score: 194.42  E-value: 1.20e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   6 SEQLVDVLIDWHVKHVYGLPGDSIDTTVDALrkQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK06725   18 AGHVIQCLKKLGVTTVFGYPGGAILPVYDAL--YESGLKHILTRHEQAAIHAAEGYARASGKVGVVFATSGPGATNLVTG 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDNL 164
Cdd:PRK06725   96 LADAYMDSIPLVVITGQVATPLIGKDGFQEADVVGITVPVTKHNYQVRDVNQLSRIVQEAFYIAESgRPGPVLIDIPKDV 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 PEQRVSDHY--ISSASSFQLTsPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTLPAKGI 240
Cdd:PRK06725  176 QNEKVTSFYneVVEIPGYKPE-PRPDSMKLREVAKAISKAKRPLLYIGGGVIHSGGseELIEFARENRIPVVSTLMGLGA 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 241 IGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP--YTAYLPK-PGRAKSIQINTSASAIGKRYPADVGLVADIKD 317
Cdd:PRK06725  255 YPPGDPLFLGMLGMHGTYAANMAVTECDLLLALGVRFDdrVTGKLELfSPHSKKVHIDIDPSEFHKNVAVEYPVVGDVKK 334
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 318 VIKQLnsSETTILHPDDGFLkacqENVANWN-RWMTGKRELDSKpVAPEALFNDINETAPHNTIYSIDVGTATSWSARFL 396
Cdd:PRK06725  335 ALHML--LHMSIHTQTDEWL----QKVKTWKeEYPLSYKQKESE-LKPQHVINLVSELTNGEAIVTTEVGQHQMWAAHFY 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 397 NVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQq 476
Cdd:PRK06725  408 KAKNPRTFLTSGGLGTMGFGFPAAIGAQLAKEEELVICIAGDASFQMNIQELQTIAENNIPVKVFIINNKFLGMVRQWQ- 486
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1586112881 477 aagQLNYQIDLQDM-----DYAKFADAAGGVGITAKTSEEFKNALNRAYrVQNMPVLINAYVSD 535
Cdd:PRK06725  487 ---EMFYENRLSESkigspDFVKVAEAYGVKGLRATNSTEAKQVMLEAF-AHEGPVVVDFCVEE 546
PRK08155 PRK08155
acetolactate synthase large subunit;
18-533 5.41e-54

acetolactate synthase large subunit;


Pssm-ID: 181257 [Multi-domain]  Cd Length: 564  Bit Score: 192.62  E-value: 5.41e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  18 VKHVYGLPGDSIDTTVDALrKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNGLYDAKMDHVPVL 97
Cdd:PRK08155   28 IRIVTGIPGGAILPLYDAL-SQSTQIRHILARHEQGAGFIAQGMARTTGKPAVCMACSGPGATNLVTAIADARLDSIPLV 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  98 ALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIP----------DNLPE 166
Cdd:PRK08155  107 CITGQVPASMIGTDAFQEVDTYGISIPITKHNYLVRDIEELPQVISDAFRIAQSgRPGPVWIDIPkdvqtavielEALPA 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 167 QRVSDhyissassfqlTSPQIDDNRLNTAAKLIRDSKKPLALVGLG--AKKAGSQVAAFLEQNHIPFISTLPAKGIIGDN 244
Cdd:PRK08155  187 PAEKD-----------AAPAFDEESIRDAAAMINAAKRPVLYLGGGviNSGAPARARELAEKAQLPTTMTLMALGMLPKA 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 245 HPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTA------YLPkpgRAKSIQINTSASAIGKRYPADVGLVADIKDV 318
Cdd:PRK08155  256 HPLSLGMLGMHGARSTNYILQEADLLIVLGARFDDRAigkteqFCP---NAKIIHVDIDRAELGKIKQPHVAIQADVDDV 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 319 IKQLNSsettilhpddgFLKACQEnvanwNRWMTGKRELDSK----------PVAPEALFNDINETAPHNTIYSIDVGTA 388
Cdd:PRK08155  333 LAQLLP-----------LVEAQPR-----AEWHQLVADLQREfpcpipkaddPLSHYGLINAVAACVDDNAIITTDVGQH 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 389 TSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKL 468
Cdd:PRK08155  397 QMWTAQAYPLNRPRQWLTSGGLGTMGFGLPAAIGAALANPERKVLCFSGDGSLMMNIQEMATAAENQLDVKIILMNNEAL 476
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586112881 469 AFIeYEQQA--------AGQLNYQIDlqdmdyakFADAAGGVGITA---KTSEEFKNALNRAYRvQNMPVLINAYV 533
Cdd:PRK08155  477 GLV-HQQQSlfygqrvfAATYPGKIN--------FMQIAAGFGLETcdlNNEADPQAALQEAIN-RPGPALIHVRI 542
PRK07979 PRK07979
acetolactate synthase 3 large subunit;
6-519 1.50e-53

acetolactate synthase 3 large subunit;


Pssm-ID: 181185 [Multi-domain]  Cd Length: 574  Bit Score: 191.60  E-value: 1.50e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   6 SEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDqIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK07979    7 AEMVVRSLIDQGVKQVFGYPGGAVLDIYDALHTVGG-IDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGATNAITG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDNL 164
Cdd:PRK07979   86 IATAYMDSIPLVVLSGQVATSLIGYDAFQECDMVGISRPVVKHSFLVKQTEDIPQVLKKAFWLAASgRPGPVVVDLPKDI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 PEQRVSDHYISSAS-SFQLTSPQIDDNR--LNTAAKLIRDSKKPLALVGLGAKKAG--SQVAAFLEQNHIPFISTLPAKG 239
Cdd:PRK07979  166 LNPANKLPYVWPESvSMRSYNPTTQGHKgqIKRALQTLVAAKKPVVYVGGGAINAAchQQLKELVEKLNLPVVSSLMGLG 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 240 IIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFG------TNYPYTAYLPKpgrAKSIQINTSASAIGKRYPADVGLVA 313
Cdd:PRK07979  246 AFPATHRQSLGMLGMHGTYEANMTMHNADVIFAVGvrfddrTTNNLAKYCPN---ATVLHIDIDPTSISKTVTADIPIVG 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 314 DIKDVIKQ---LNSSETTILHPDDgfLKACQENVANWNRWMTGKRELDSKPVAPEALFNDINETAPHNTIYSIDVGTATS 390
Cdd:PRK07979  323 DARQVLEQmleLLSQESAHQPLDE--IRDWWQQIEQWRARQCLKYDTHSEKIKPQAVIETLWRLTKGDAYVTSDVGQHQM 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 391 WSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAF 470
Cdd:PRK07979  401 FAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPEETVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM 480
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1586112881 471 IEYEQ--QAAGQlNYQIDLQDM-DYAKFADAAGGVGITAKTSEEFKNALNRA 519
Cdd:PRK07979  481 VKQWQdmIYSGR-HSQSYMQSLpDFVRLAEAYGHVGIQISHPDELESKLSEA 531
sulphoacet_xsc TIGR03457
sulfoacetaldehyde acetyltransferase; Members of this protein family are sulfoacetaldehyde ...
6-524 3.87e-52

sulfoacetaldehyde acetyltransferase; Members of this protein family are sulfoacetaldehyde acetyltransferase, an enzyme of taurine utilization. Taurine, or 2-aminoethanesulfonate, can be used by bacteria as a source of carbon, nitrogen, and sulfur. [Central intermediary metabolism, Other]


Pssm-ID: 132497 [Multi-domain]  Cd Length: 579  Bit Score: 187.76  E-value: 3.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   6 SEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQdqIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:TIGR03457   5 SEAFVEVLVANGVTHAFGIMGSAFMDAMDLFPPAG--IRFIPVVHEQGAGHMADGFARVTGRMSMVIGQNGPGVTNCVTA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTIPDNLP 165
Cdd:TIGR03457  83 IAAAYWAHTPVVIVTPEAGTKTIGLGGFQEADQLPMFQEFTKYQGHVRHPSRMAEVLNRCFERAWREMGPAQLNIPRDYF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 166 EQRVsdhYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLG-------------AKKAGSQVAAFLEQNhipfi 232
Cdd:TIGR03457 163 YGEI---DVEIPRPVRLDRGAGGATSLAQAARLLAEAKFPVIISGGGvvmgdaveeckalAERLGAPVVNSYLHN----- 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 233 STLPAkgiigdNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPK------PGRAKSIQINTSASAIGKRYP 306
Cdd:TIGR03457 235 DSFPA------SHPLWVGPLGYQGSKAAMKLISDADVVLALGTRLGPFGTLPQygidywPKNAKIIQVDANAKMIGLVKK 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 307 ADVGLVADIKDVIKQLnsseTTILHPDDGFLK------ACQENVANWNR---------------WMTGKRELDSKPVAPE 365
Cdd:TIGR03457 309 VTVGICGDAKAAAAEI----LQRLAGKAGDANraerkaKIQAERSAWEQelsemtherdpfsldMIVEQRQEEGNWLHPR 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 366 ALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVM 445
Cdd:TIGR03457 385 QVLRELEKAMPEDAIVSTDIGNINSVANSYLRFEKPRKFLAPMSFGNCGYAFPTIIGAKIAAPDRPVVAYAGDGAWGMSM 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 446 QDFITAVKYKLPLINIVLNNsklafieyEQQAAGQLNyQIDLQD-----------MDYAKFADAAGGVGITAKTSEEFKN 514
Cdd:TIGR03457 465 NEIMTAVRHDIPVTAVVFRN--------RQWGAEKKN-QVDFYNnrfvgteleseLSFAGIADAMGAKGVVVDKPEDVGP 535
                         570
                  ....*....|
gi 1586112881 515 ALNRAYRVQN 524
Cdd:TIGR03457 536 ALKKAIAAQA 545
PRK07525 PRK07525
sulfoacetaldehyde acetyltransferase; Validated
1-524 6.70e-51

sulfoacetaldehyde acetyltransferase; Validated


Pssm-ID: 236042 [Multi-domain]  Cd Length: 588  Bit Score: 184.43  E-value: 6.70e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQKASEQLVDVLIDWHVKHVYGLPG----DSIDTTVDAlrkqqdQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGG 76
Cdd:PRK07525    4 MKMTPSEAFVETLQAHGITHAFGIIGsafmDASDLFPPA------GIRFIDVAHEQNAGHMADGYTRVTGRMGMVIGQNG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  77 PGAIHILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVA 156
Cdd:PRK07525   78 PGITNFVTAVATAYWAHTPVVLVTPQAGTKTIGQGGFQEAEQMPMFEDMTKYQEEVRDPSRMAEVLNRVFDKAKRESGPA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 157 VLTIPDNLPEQRVSdhyISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFIST 234
Cdd:PRK07525  158 QINIPRDYFYGVID---VEIPQPVRLERGAGGEQSLAEAAELLSEAKFPVILSGAGVVLSDAieECKALAERLDAPVACG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 235 ------LPAkgiigdNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYPYTAYLPK------PGRAKSIQINTSASAIG 302
Cdd:PRK07525  235 ylhndaFPG------SHPLWVGPLGYNGSKAAMELIAKADVVLALGTRLNPFGTLPQygidywPKDAKIIQVDINPDRIG 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 303 KRYPADVGLVADIKDVIKQLNS--SETTilhPDDGFLKACQENVAN----WNR---------------WMTGKRELDSKP 361
Cdd:PRK07525  309 LTKKVSVGICGDAKAVARELLArlAERL---AGDAGREERKALIAAeksaWEQelsswdhedddpgtdWNEEARARKPDY 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 362 VAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAF 441
Cdd:PRK07525  386 MHPRQALREIQKALPEDAIVSTDIGNNCSIANSYLRFEKGRKYLAPGSFGNCGYAFPAIIGAKIACPDRPVVGFAGDGAW 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 442 AMVMQDFITAVKYKLPLINIVLNNSklafieyeQQAAGQLNyQIDL-----------QDMDYAKFADAAGGVGITAKTSE 510
Cdd:PRK07525  466 GISMNEVMTAVRHNWPVTAVVFRNY--------QWGAEKKN-QVDFynnrfvgteldNNVSYAGIAEAMGAEGVVVDTQE 536
                         570
                  ....*....|....
gi 1586112881 511 EFKNALNRAYRVQN 524
Cdd:PRK07525  537 ELGPALKRAIDAQN 550
PRK07710 PRK07710
acetolactate synthase large subunit;
6-542 2.44e-50

acetolactate synthase large subunit;


Pssm-ID: 236076 [Multi-domain]  Cd Length: 571  Bit Score: 182.65  E-value: 2.44e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   6 SEQLVDVLIDWHVKHVYGLPGDSIDTTVDALrkQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK07710   19 AQMLIEALEKEGVEVIFGYPGGAVLPLYDAL--YDCGIPHILTRHEQGAIHAAEGYARISGKPGVVIATSGPGATNVVTG 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDNL 164
Cdd:PRK07710   97 LADAMIDSLPLVVFTGQVATSVIGSDAFQEADIMGITMPVTKHNYQVRKASDLPRIIKEAFHIATTgRPGPVLIDIPKDM 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 PE---QRVSDHYISSASSFQLTSP---QIddNRLNTAaklIRDSKKPLALVGLGA--KKAGSQVAAFLEQNHIPFISTLP 236
Cdd:PRK07710  177 VVeegEFCYDVQMDLPGYQPNYEPnllQI--RKLVQA---VSVAKKPVILAGAGVlhAKASKELTSYAEQQEIPVVHTLL 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 237 AKGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP-----YTAYLPKpgRAKSIQINTSASAIGKRYPADVGL 311
Cdd:PRK07710  252 GLGGFPADHPLFLGMAGMHGTYTANMALYECDLLINIGARFDdrvtgNLAYFAK--EATVAHIDIDPAEIGKNVPTEIPI 329
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 312 VADIKDVIKQLnssettiLHPDDGflkacQENVANW----NRWmtgKREL------DSKPVAPEALFNDINETAPHNTIY 381
Cdd:PRK07710  330 VADAKQALQVL-------LQQEGK-----KENHHEWlsllKNW---KEKYplsykrNSESIKPQKAIEMLYEITKGEAIV 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 382 SIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINI 461
Cdd:PRK07710  395 TTDVGQHQMWAAQYYPFKTPDKWVTSGGLGTMGFGLPAAIGAQLAKPDETVVAIVGDGGFQMTLQELSVIKELSLPVKVV 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 462 VLNNSKLAFIEYEQQAAGQLNYQIDL--QDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRVQNmPVLINAYVSDDA-- 537
Cdd:PRK07710  475 ILNNEALGMVRQWQEEFYNQRYSHSLlsCQPDFVKLAEAYGIKGVRIDDELEAKEQLQHAIELQE-PVVIDCRVLQSEkv 553

                  ....*...
gi 1586112881 538 -PL--PGK 542
Cdd:PRK07710  554 mPMvaPGK 561
PLN02470 PLN02470
acetolactate synthase
3-471 1.37e-49

acetolactate synthase


Pssm-ID: 215261 [Multi-domain]  Cd Length: 585  Bit Score: 180.70  E-value: 1.37e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   3 QKASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQqDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHI 82
Cdd:PLN02470   13 RKGADILVEALEREGVDTVFAYPGGASMEIHQALTRS-NCIRNVLCRHEQGEVFAAEGYAKASGKVGVCIATSGPGATNL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  83 LNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIP 161
Cdd:PLN02470   92 VTGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRVIREAFFLASSgRPGPVLVDIP 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 162 DNLPEQRVSDHY---ISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFISTLPAK 238
Cdd:PLN02470  172 KDIQQQLAVPNWnqpMKLPGYLSRLPKPPEKSQLEQIVRLISESKRPVVYVGGGCLNSSEELREFVELTGIPVASTLMGL 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 239 GIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFGTNYP--YTAYLPK-PGRAKSIQINTSASAIGKRYPADVGLVADI 315
Cdd:PLN02470  252 GAFPASDELSLQMLGMHGTVYANYAVDSADLLLAFGVRFDdrVTGKLEAfASRASIVHIDIDPAEIGKNKQPHVSVCADV 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 316 KDVIKQLNSsettILHPDdgflKACQENVANWNRWMTGKRE-------LDSKPVAPEALFNDINETAPHNTIYSIDVGTA 388
Cdd:PLN02470  332 KLALQGLNK----LLEER----KAKRPDFSAWRAELDEQKEkfplsypTFGDAIPPQYAIQVLDELTDGNAIISTGVGQH 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 389 TSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKL 468
Cdd:PLN02470  404 QMWAAQWYKYKEPRRWLTSGGLGAMGFGLPAAIGAAAANPDAIVVDIDGDGSFIMNIQELATIHVENLPVKIMVLNNQHL 483

                  ...
gi 1586112881 469 AFI 471
Cdd:PLN02470  484 GMV 486
PRK06466 PRK06466
acetolactate synthase 3 large subunit;
7-533 1.41e-49

acetolactate synthase 3 large subunit;


Pssm-ID: 180578 [Multi-domain]  Cd Length: 574  Bit Score: 180.71  E-value: 1.41e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   7 EQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQqDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNGL 86
Cdd:PRK06466    8 EMLVRALRDEGVEYIYGYPGGAVLHIYDALFKQ-DKVEHILVRHEQAATHMADGYARATGKTGVVLVTSGPGATNAITGI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  87 YDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAVLTIPDNL- 164
Cdd:PRK06466   87 ATAYMDSIPMVVLSGQVPSTLIGEDAFQETDMVGISRPIVKHSFMVKHASEIPEIIKKAFYIAQSgRPGPVVVDIPKDMt 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 165 -PEQRVSDHYISSAS--SFQLT----SPQIddnrlNTAAKLIRDSKKPLALVGLGA--KKAGSQVAAFLEQNHIPFISTL 235
Cdd:PRK06466  167 nPAEKFEYEYPKKVKlrSYSPAvrghSGQI-----RKAVEMLLAAKRPVIYSGGGVvlGNASALLTELAHLLNLPVTNTL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 236 PAKGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDLLLMFG-------TNYPyTAYLPKpgrAKSIQINTSASAIGKRYPAD 308
Cdd:PRK06466  242 MGLGGFPGTDRQFLGMLGMHGTYEANMAMHHADVILAVGarfddrvTNGP-AKFCPN---AKIIHIDIDPASISKTIKAD 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 309 VGLVADIKDVIKQLnsseTTILHPDDGflKACQENVANW----NRW-----MTGKRELDSKPVAPEALFNDINETAPHNT 379
Cdd:PRK06466  318 IPIVGPVESVLTEM----LAILKEIGE--KPDKEALAAWwkqiDEWrgrhgLFPYDKGDGGIIKPQQVVETLYEVTNGDA 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 380 IYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLI 459
Cdd:PRK06466  392 YVTSDVGQHQMFAAQYYKFNKPNRWINSGGLGTMGFGLPAAMGVKLAFPDQDVACVTGEGSIQMNIQELSTCLQYGLPVK 471
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586112881 460 NIVLNNSKLAFIEYEQQAAGQLNYQIDLQDM--DYAKFADAAGGVGITAKTSEEFKNALNRAYRVQNMPVLINAYV 533
Cdd:PRK06466  472 IINLNNGALGMVRQWQDMQYEGRHSHSYMESlpDFVKLAEAYGHVGIRITDLKDLKPKLEEAFAMKDRLVFIDIYV 547
PRK06112 PRK06112
acetolactate synthase catalytic subunit; Validated
63-537 1.01e-47

acetolactate synthase catalytic subunit; Validated


Pssm-ID: 235700 [Multi-domain]  Cd Length: 578  Bit Score: 175.33  E-value: 1.01e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  63 KLTGKLGVCLSIGGPGAIHILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIV 142
Cdd:PRK06112   70 RVSGKVAVVTAQNGPAATLLVAPLAEALKASVPIVALVQDVNRDQTDRNAFQELDHIALFQSCTKWVRRVTVAERIDDYV 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 143 DEAIRTAYE-KHGVAVLTIPDNL---PEQRVSDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLG--AKKA 216
Cdd:PRK06112  150 DQAFTAATSgRPGPVVLLLPADLltaAAAAPAAPRSNSLGHFPLDRTVPAPQRLAEAASLLAQAQRPVVVAGGGvhISGA 229
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 217 GSQVAAFLEQNHIPFISTLPAKGIIGDNHPNSLGNVGKL-----GTKPAYEAMQNTDLLLMFG--TNYPYTA-YLPKPGR 288
Cdd:PRK06112  230 SAALAALQSLAGLPVATTNMGKGAVDETHPLSLGVVGSLmgprsPGRHLRDLVREADVVLLVGtrTNQNGTDsWSLYPEQ 309
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 289 AKSIQINTSASAIGKRYPAdVGLVADIKDVIKQLNSSET----TILHPDDGFLKACQEnvANWNRW---MTGKRELDSKP 361
Cdd:PRK06112  310 AQYIHIDVDGEEVGRNYEA-LRLVGDARLTLAALTDALRgrdlAARAGRRAALEPAIA--AGREAHredSAPVALSDASP 386
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 362 VAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNV-SPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGA 440
Cdd:PRK06112  387 IRPERIMAELQAVLTGDTIVVADASYSSIWVANFLTArRAGMRFLTPRGLAGLGWGVPMAIGAKVARPGAPVICLVGDGG 466
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 441 FAMVMQDFITAVKYKLPLINIVLNNSKLAF-IEYEQQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRA 519
Cdd:PRK06112  467 FAHVWAELETARRMGVPVTIVVLNNGILGFqKHAETVKFGTHTDACHFAAVDHAAIARACGCDGVRVEDPAELAQALAAA 546
                         490
                  ....*....|....*...
gi 1586112881 520 YRVQnMPVLINAYVSDDA 537
Cdd:PRK06112  547 MAAP-GPTLIEVITDPSA 563
TPP_enzyme_C pfam02775
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;
384-531 1.05e-43

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;


Pssm-ID: 460689 [Multi-domain]  Cd Length: 151  Bit Score: 152.74  E-value: 1.05e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 384 DVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVL 463
Cdd:pfam02775   1 DIGCHQMWAAQYYRFRPPRRYLTSGGLGTMGYGLPAAIGAKLARPDRPVVAIAGDGGFQMNLQELATAVRYNLPITVVVL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586112881 464 NNSKLAFIEYEQQAAGQLNY----QIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINA 531
Cdd:pfam02775  81 NNGGYGMTRGQQTPFGGGRYsgpsGKILPPVDFAKLAEAYGAKGARVESPEELEEALKEALE-HDGPALIDV 151
PDC1 COG3961
TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate ...
76-538 1.81e-39

TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]; TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 443161 [Multi-domain]  Cd Length: 545  Bit Score: 151.46  E-value: 1.81e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  76 GPGAIHILNGLYDAKMDHVPVLALLG------QV----------DTQFlneEYFQEVntpqlFADVAVYNKLISATDNLA 139
Cdd:COG3961    76 GVGELSAINGIAGAYAERVPVVHIVGapgtraQRrgpllhhtlgDGDF---DHFLRM-----FEEVTVAQAVLTPENAAA 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 140 EIvDEAIRTAYEKHGVAVLTIPDNLPEQRVSdhyiSSASSFQLTSPQIDDNRLNTA----AKLIRDSKKPLALVGLGAKK 215
Cdd:COG3961   148 EI-DRVLAAALREKRPVYIELPRDVADAPIE----PPEAPLPLPPPASDPAALAAAvaaaAERLAKAKRPVILAGVEVHR 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 216 AG--SQVAAFLEQNHIPFISTLPAKGIIGDNHPNSLGN-VGKLGTKPAYEAMQNTDLLLMFGTNYP------YTAYLPkp 286
Cdd:COG3961   223 FGlqEELLALAEKTGIPVATTLLGKSVLDESHPQFIGTyAGAASSPEVREYVENADCVLCLGVVFTdtntggFTAQLD-- 300
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 287 gRAKSIQINTSASAIGKRYPADVGLvadiKDVIKQLNssettilhpddgflkacqENVANWNRWMTGKRELDSKPVAP-- 364
Cdd:COG3961   301 -PERTIDIQPDSVRVGGHIYPGVSL----ADFLEALA------------------ELLKKRSAPLPAPAPPPPPPPAApd 357
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 365 -----EALFNDINETAPHNTIYSIDVGTAtSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDG 439
Cdd:COG3961   358 apltqDRLWQRLQAFLDPGDIVVADTGTS-LFGAADLRLPEGATFIAQPLWGSIGYTLPAALGAALAAPDRRVILLVGDG 436
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 440 AFAMVMQDFITAVKYKLPLINIVLNNSKLA---FIEYEQQAagqlnYQiDLQDMDYAKFADAAGG---VGITAKTSEEFK 513
Cdd:COG3961   437 AFQLTAQELSTMLRYGLKPIIFVLNNDGYTierAIHGPDGP-----YN-DIANWDYAKLPEAFGGgnaLGFRVTTEGELE 510
                         490       500
                  ....*....|....*....|....*.
gi 1586112881 514 NALNRAYRVQNMPVLINAYVS-DDAP 538
Cdd:COG3961   511 EALAAAEANTDRLTLIEVVLDkMDAP 536
PRK11269 PRK11269
glyoxylate carboligase; Provisional
1-529 2.04e-39

glyoxylate carboligase; Provisional


Pssm-ID: 183066 [Multi-domain]  Cd Length: 591  Bit Score: 152.06  E-value: 2.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   1 MAQ-KASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQdQIGFVQVRHEEVASLAAAAEAKLT-GKLGVCLSIGGPG 78
Cdd:PRK11269    1 MAKmRAVDAAVLVLEKEGVTTAFGVPGAAINPFYSAMRKHG-GIRHILARHVEGASHMAEGYTRATaGNIGVCIGTSGPA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  79 AIHILNGLYDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYE-KHGVAV 157
Cdd:PRK11269   80 GTDMITGLYSASADSIPILCITGQAPRARLHKEDFQAVDIESIAKPVTKWAVTVREPALVPRVFQQAFHLMRSgRPGPVL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 158 LTIPDNLPEQRVsDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTL 235
Cdd:PRK11269  160 IDLPFDVQVAEI-EFDPDTYEPLPVYKPAATRAQIEKALEMLNAAERPLIVAGGGVINADAsdLLVEFAELTGVPVIPTL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 236 PAKGIIGDNHPNSLGNVGkLGTKPAY--EAMQNTDLLLMFGTNYP---------YTAylpkpGRaKSIQINTSASAIGKR 304
Cdd:PRK11269  239 MGWGAIPDDHPLMAGMVG-LQTSHRYgnATLLASDFVLGIGNRWAnrhtgsvevYTK-----GR-KFVHVDIEPTQIGRV 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 305 YPADVGLVADIK-------DVIKQLNSSETtiLHPDDGFLKACQENvanwNRWMTGKRELDSKPVAPEALFNDINETAPH 377
Cdd:PRK11269  312 FGPDLGIVSDAKaalellvEVAREWKAAGR--LPDRSAWVADCQER----KRTLLRKTHFDNVPIKPQRVYEEMNKAFGR 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 378 NTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLP 457
Cdd:PRK11269  386 DTCYVSTIGLSQIAAAQFLHVYKPRHWINCGQAGPLGWTIPAALGVRAADPDRNVVALSGDYDFQFLIEELAVGAQFNLP 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 458 LINIVLNNSKLAFIEyEQQAAGQLNYQIDLQ------------DMDYAKFADAAGGVGITAKTSEEFKNALNRA------ 519
Cdd:PRK11269  466 YIHVLVNNAYLGLIR-QAQRAFDMDYCVQLAfeninspelngyGVDHVKVAEGLGCKAIRVFKPEDIAPALEQAkalmae 544
                         570
                  ....*....|
gi 1586112881 520 YRVqnmPVLI 529
Cdd:PRK11269  545 FRV---PVVV 551
PRK07064 PRK07064
thiamine pyrophosphate-binding protein;
7-529 2.66e-39

thiamine pyrophosphate-binding protein;


Pssm-ID: 180820 [Multi-domain]  Cd Length: 544  Bit Score: 151.30  E-value: 2.66e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   7 EQLVDVLIDWHVKHVYG------LPgdsidtTVDALrKQQDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAI 80
Cdd:PRK07064    7 ELIAAFLEQCGVKTAFGvisihnMP------ILDAI-GRRGKIRFVPARGEAGAVNMADAHARVSGGLGVALTSTGTGAG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLALLGQVDTQFLNEE--YFQEV-NTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEK-HGVA 156
Cdd:PRK07064   80 NAAGALVEALTAGTPLLHITGQIETPYLDQDlgYIHEApDQLTMLRAVSKAAFRVRSAETALATIREAVRVALTApTGPV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 157 VLTIPDNLpeQRVSDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNhIPFISTLP 236
Cdd:PRK07064  160 SVEIPIDI--QAAEIELPDDLAPVHVAVPEPDAAAVAELAERLAAARRPLLWLGGGARHAGAEVKRLVDLG-FGVVTSTQ 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 237 AKGIIGDNHPNSLGNVGklGTKPAYEAMQNTDLLLMFGTNY------PYTAYLPKPgrakSIQINTSASAIGKRYPADVG 310
Cdd:PRK07064  237 GRGVVPEDHPASLGAFN--NSAAVEALYKTCDLLLVVGSRLrgnetlKYSLALPRP----LIRVDADAAADGRGYPNDLF 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 311 LVADIKDVIKQLNSSETTILHPDDGFLKACQENVANWNRWMTgkreldsKPVAPEALFND-INETAPHNTIYSIDVGTAT 389
Cdd:PRK07064  311 VHGDAARVLARLADRLEGRLSVDPAFAADLRAAREAAVADLR-------KGLGPYAKLVDaLRAALPRDGNWVRDVTISN 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 390 S-WSARFLNV-SPTQKfiLSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSK 467
Cdd:PRK07064  384 StWGNRLLPIfEPRAN--VHALGGGIGQGLAMAIGAALAGPGRKTVGLVGDGGLMLNLGELATAVQENANMVIVLMNDGG 461
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586112881 468 LAFIEYEQQAA-GQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRVQNmPVLI 529
Cdd:PRK07064  462 YGVIRNIQDAQyGGRRYYVELHTPDFALLAASLGLPHWRVTSADDFEAVLREALAKEG-PVLV 523
TPP_AHAS cd02015
Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding ...
362-537 4.89e-39

Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate. 2-Acetolactate is the precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. In addition to requiring TPP and a divalent metal ion as cofactors, AHAS requires FAD.


Pssm-ID: 238973 [Multi-domain]  Cd Length: 186  Bit Score: 141.10  E-value: 4.89e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 362 VAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAF 441
Cdd:cd02015     1 IKPQEVIKELSELTPGDAIVTTDVGQHQMWAAQYYRFKKPRSWLTSGGLGTMGFGLPAAIGAKVARPDKTVICIDGDGSF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 442 AMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQLNYQIDLQDM--DYAKFADAAGGVGITAKTSEEFKNALNRA 519
Cdd:cd02015    81 QMNIQELATAAQYNLPVKIVILNNGSLGMVRQWQELFYEGRYSHTTLDSnpDFVKLAEAYGIKGLRVEKPEELEAALKEA 160
                         170
                  ....*....|....*...
gi 1586112881 520 YRVQNmPVLINAYVSDDA 537
Cdd:cd02015   161 LASDG-PVLLDVLVDPEE 177
TPP_enzyme_M pfam00205
Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a ...
192-322 5.34e-39

Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a 2-fold Rossman fold.


Pssm-ID: 425523 [Multi-domain]  Cd Length: 137  Bit Score: 139.62  E-value: 5.34e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 192 LNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQNHIPFISTLPAKGIIGDNHPNSLGNVGKLGTKPAYEAMQNTDL 269
Cdd:pfam00205   1 IEKAAELLKKAKRPVILAGGGVRRSGAseELRELAEKLGIPVVTTLMGKGAFPEDHPLYLGMLGMHGTPAANEALEEADL 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1586112881 270 LLMFGTNYP----YTAYLPKPGRAKSIQINTSASAIGKRYPADVGLVADIKDVIKQL 322
Cdd:pfam00205  81 VLAVGARFDdirtTGKLPEFAPDAKIIHIDIDPAEIGKNYPVDVPIVGDAKETLEAL 137
TPP_enzymes cd00568
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ...
366-533 1.18e-38

Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.


Pssm-ID: 238318 [Multi-domain]  Cd Length: 168  Bit Score: 139.70  E-value: 1.18e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 366 ALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVM 445
Cdd:cd00568     1 RVLAALRAALPEDAIVVNDAGNSAYWAYRYLPLRRGRRFLTSTGFGAMGYGLPAAIGAALAAPDRPVVCIAGDGGFMMTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 446 QDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQLNYQ-IDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAyRVQN 524
Cdd:cd00568    81 QELATAVRYGLPVIVVVFNNGGYGTIRMHQEAFYGGRVSgTDLSNPDFAALAEAYGAKGVRVEDPEDLEAALAEA-LAAG 159

                  ....*....
gi 1586112881 525 MPVLINAYV 533
Cdd:cd00568   160 GPALIEVKT 168
PRK06154 PRK06154
thiamine pyrophosphate-requiring protein;
4-529 1.64e-38

thiamine pyrophosphate-requiring protein;


Pssm-ID: 235718 [Multi-domain]  Cd Length: 565  Bit Score: 149.19  E-value: 1.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   4 KASEQLVDVLIDWHVKHVYGLPGDS-IDTTVDAlrkqqdQIGFVQVRHEEVASLAAAAEAKLTG--KLGVCLSIGGPGAI 80
Cdd:PRK06154   21 KVAEAVAEILKEEGVELLFGFPVNElFDAAAAA------GIRPVIARTERVAVHMADGYARATSgeRVGVFAVQYGPGAE 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  81 HILNGLYDAKMDHVPVLAL-------LGQVDTQFLNEEYFQEVNTPqlfadvavynkliSATDNLAEIVDEAIRTAYEK- 152
Cdd:PRK06154   95 NAFGGVAQAYGDSVPVLFLptgyprgSTDVAPNFESLRNYRHITKW-------------CEQVTLPDEVPELMRRAFTRl 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 153 ----HGVAVLTIPDNLPEQRVSDHYISSASSfQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGS--QVAAFLEQ 226
Cdd:PRK06154  162 rngrPGPVVLELPVDVLAEELDELPLDHRPS-RRSRPGADPVEVVEAAALLLAAERPVIYAGQGVLYAQAtpELKELAEL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 227 NHIPFISTLPAKGIIGDNHPNSLGNVGKlgTKPAYEA--MQNTDLLLMFGTNYPYTAY-LPKPGRAKSIQINTSASAIGK 303
Cdd:PRK06154  241 LEIPVMTTLNGKSAFPEDHPLALGSGGR--ARPATVAhfLREADVLFGIGCSLTRSYYgLPMPEGKTIIHSTLDDADLNK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 304 RYPADVGLVADIKDVIKQLNSSETTILHPDDGFLKACQENVA----NW-NRWMTgKRELDSKPVAPEALFNDINET-APH 377
Cdd:PRK06154  319 DYPIDHGLVGDAALVLKQMIEELRRRVGPDRGRAQQVAAEIEavraAWlAKWMP-KLTSDSTPINPYRVVWELQHAvDIK 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 378 NTIYSIDVGTATSWSARFLNVSPTqkfilSSYLG-----TMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAV 452
Cdd:PRK06154  398 TVIITHDAGSPRDQLSPFYVASRP-----GSYLGwgkttQLGYGLGLAMGAKLARPDALVINLWGDAAFGMTGMDFETAV 472
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1586112881 453 KYKLPLINIVLNNSKLAfIEYEQQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRV--QNMPVLI 529
Cdd:PRK06154  473 RERIPILTILLNNFSMG-GYDKVMPVSTTKYRATDISGDYAAIARALGGYGERVEDPEMLVPALLRALRKvkEGTPALL 550
PRK07524 PRK07524
5-guanidino-2-oxopentanoate decarboxylase;
7-529 1.91e-37

5-guanidino-2-oxopentanoate decarboxylase;


Pssm-ID: 236041 [Multi-domain]  Cd Length: 535  Bit Score: 145.89  E-value: 1.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   7 EQLVDVLIDWHVKHVYGLPGDSidtTVDALRKQQDQ-IGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNG 85
Cdd:PRK07524    6 EALVRLLEAYGVETVFGIPGVH---TVELYRGLAGSgIRHVTPRHEQGAGFMADGYARVSGKPGVCFIITGPGMTNIATA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  86 LYDAKMDHVPVLALLG--QVDTQFLNEEYFQEVNTPQ-LFADVAVYNKLISATDNLAEIVDEAIrtayekhgvAVLT--- 159
Cdd:PRK07524   83 MGQAYADSIPMLVISSvnRRASLGKGRGKLHELPDQRaMVAGVAAFSHTLMSAEDLPEVLARAF---------AVFDsar 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 160 -------IPDNLPEQRVSDhyISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAAFLEQNHIPFI 232
Cdd:PRK07524  154 prpvhieIPLDVLAAPADH--LLPAPPTRPARPGPAPAALAQAAERLAAARRPLILAGGGALAAAAALRALAERLDAPVA 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 233 STLPAKGIIGDNHPNSLGNVGKLgtKPAYEAMQNTDLLLMFGTNYPYTAY-------LPKPGRAksIQINTSASAIGKRY 305
Cdd:PRK07524  232 LTINAKGLLPAGHPLLLGASQSL--PAVRALIAEADVVLAVGTELGETDYdvyfdggFPLPGEL--IRIDIDPDQLARNY 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 306 PADVGLVADIKDVIKQL-NSSETTILHPDDGFLKAC---QENVANWNRWMTGKReldskpvapeALFNDINETAPHNTIy 381
Cdd:PRK07524  308 PPALALVGDARAALEALlARLPGQAAAADWGAARVAalrQALRAEWDPLTAAQV----------ALLDTILAALPDAIF- 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 382 sidVG--TATSWSARFLNVSPTQK--FILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLP 457
Cdd:PRK07524  377 ---VGdsTQPVYAGNLYFDADAPRrwFNASTGYGTLGYGLPAAIGAALGAPERPVVCLVGDGGLQFTLPELASAVEADLP 453
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586112881 458 LINIVLNNSKLAFIEYEQQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAyRVQNMPVLI 529
Cdd:PRK07524  454 LIVLLWNNDGYGEIRRYMVARDIEPVGVDPYTPDFIALARAFGCAAERVADLEQLQAALRAA-FARPGPTLI 524
TPP_enzyme_N pfam02776
Thiamine pyrophosphate enzyme, N-terminal TPP binding domain;
5-171 1.36e-34

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain;


Pssm-ID: 460690 [Multi-domain]  Cd Length: 169  Bit Score: 128.51  E-value: 1.36e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   5 ASEQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKQqDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILN 84
Cdd:pfam02776   1 GAEALADVLKALGVDTVFGVPGGHILPLLDALAKS-PGIRYVLTRHEQGAAFAADGYARATGKPGVVLVTSGPGATNALT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  85 GLYDAKMDHVPVLALLGQVDTQFLNEEYFQ-EVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTA-YEKHGVAVLTIPD 162
Cdd:pfam02776  80 GLANAYVDSVPLLVISGQRPRSLVGRGALQqELDQLALFRPVTKWAVRVTSADEIPEVLRRAFRAAlSGRPGPVYLEIPL 159

                  ....*....
gi 1586112881 163 NLPEQRVSD 171
Cdd:pfam02776 160 DVLLEEVDE 168
TPP_ALS cd02010
Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; ...
364-530 9.53e-34

Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2 molecules of pyruvate to acetolactate and carbon dioxide. ALS does not contain FAD, and requires TPP and a divalent metal cation for activity.


Pssm-ID: 238968 [Multi-domain]  Cd Length: 177  Bit Score: 126.63  E-value: 9.53e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 364 PEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAM 443
Cdd:cd02010     1 PQRIVHDLRAVMGDDDIVLLDVGAHKIWMARYYRTYAPNTCLISNGLATMGVALPGAIGAKLVYPDRKVVAVSGDGGFMM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 444 VMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQ 523
Cdd:cd02010    81 NSQELETAVRLKIPLVVLIWNDNGYGLIKWKQEKEYGRDSGVDFGNPDFVKYAESFGAKGYRIESADDLLPVLERALA-A 159

                  ....*..
gi 1586112881 524 NMPVLIN 530
Cdd:cd02010   160 DGVHVID 166
TPP_BZL_OCoD_HPCL cd02004
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of ...
364-534 2.95e-32

Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules of benzaldehyde and enabling the Pseudomonas to grow on benzoin as the sole carbon and energy source. OCoD has a role in the detoxification of oxalate, catalyzing the decarboxylation of oxalyl-CoA to formate. 2-HPCL is a peroxisomal enzyme which plays a role in the alpha-oxidation of 3-methyl-branched fatty acids, catalyzing the cleavage of 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. All these enzymes depend on Mg2+ and TPP for activity.


Pssm-ID: 238962 [Multi-domain]  Cd Length: 172  Bit Score: 122.26  E-value: 2.95e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 364 PEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAM 443
Cdd:cd02004     1 PYRVLHELQEALPDDAIIVSDGGNTMDWARYILRPRKPRHRLDAGTFGTLGVGLGYAIAAALARPDKRVVLVEGDGAFGF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 444 VMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQ--AAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYR 521
Cdd:cd02004    81 SGMELETAVRYNLPIVVVVGNNGGWYQGLDGQQlsYGLGLPVTTLLPDTRYDLVAEAFGGKGELVTTPEELKPALKRALA 160
                         170
                  ....*....|...
gi 1586112881 522 vQNMPVLINAYVS 534
Cdd:cd02004   161 -SGKPALINVIID 172
PRK09259 PRK09259
putative oxalyl-CoA decarboxylase; Validated
9-537 4.75e-31

putative oxalyl-CoA decarboxylase; Validated


Pssm-ID: 236433 [Multi-domain]  Cd Length: 569  Bit Score: 127.41  E-value: 4.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   9 LVDVLIDWHVKHVYGLPGdsIDTTvDALRKQQDQ-IGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNGLY 87
Cdd:PRK09259   16 VIDALKLNGIDTIYGVVG--IPIT-DLARLAQAEgIRYIGFRHEQSAGNAAAAAGFLTQKPGVCLTVSAPGFLNGLTALA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  88 DAKMDHVPVLALLGQ-----VDTQFLNEEYFQEVNTPQLFADVAVYnklISATDNLAEIVDEAIRTAYE-KHGVAVLTIP 161
Cdd:PRK09259   93 NATTNCFPMIMISGSsereiVDLQQGDYEELDQLNAAKPFCKAAFR---VNRAEDIGIGVARAIRTAVSgRPGGVYLDLP 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 162 DNLPEQrVSDHYISSASSFQLTSP---QI-DDNRLNTAAKLIRDSKKPLALVGLGA--KKAGSQVAAFLEQNHIPFISTL 235
Cdd:PRK09259  170 AKVLAQ-TMDADEALTSLVKVVDPapaQLpAPEAVDRALDLLKKAKRPLIILGKGAayAQADEQIREFVEKTGIPFLPMS 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 236 PAKGIIGDNHPNSLGNVGKLgtkpayeAMQNTDLLLMFGTNYPYTAYLPKP----GRAKSIQINTSASAIGKRYPADVGL 311
Cdd:PRK09259  249 MAKGLLPDTHPQSAAAARSL-------ALANADVVLLVGARLNWLLSHGKGktwgADKKFIQIDIEPQEIDSNRPIAAPV 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 312 VADIKDVIKQLNSS-ETTILHPDDGFLKACQENVANWNRWMTGKRELDSKPV----APEALFNDINEtapHNTIYSIDVG 386
Cdd:PRK09259  322 VGDIGSVMQALLAGlKQNTFKAPAEWLDALAERKEKNAAKMAEKLSTDTQPMnfynALGAIRDVLKE---NPDIYLVNEG 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 387 TATSWSAR-FLNVSPTQKFILSSYLGTMGCALPGAIAAKINyPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNN 465
Cdd:PRK09259  399 ANTLDLARnIIDMYKPRHRLDCGTWGVMGIGMGYAIAAAVE-TGKPVVAIEGDSAFGFSGMEVETICRYNLPVTVVIFNN 477
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586112881 466 SKL-AFIEYEQQAAGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAyVSDDA 537
Cdd:PRK09259  478 GGIyRGDDVNLSGAGDPSPTVLVHHARYDKMMEAFGGVGYNVTTPDELRHALTEAIA-SGKPTLINV-VIDPA 548
TPP_PYR_POX_like cd07035
Pyrimidine (PYR) binding domain of POX and related proteins; Thiamine pyrophosphate (TPP ...
7-161 7.33e-29

Pyrimidine (PYR) binding domain of POX and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate oxidase (POX) and related protiens subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. For glyoxylate carboligase, which belongs to this subfamily, but lacks this conserved glutamate, the rate of the initial TPP activation step is reduced but the ensuing steps of the enzymic reaction proceed efficiently. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites, for many the active sites lie between PP and PYR domains on different subunits. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. This subfamily includes pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC catalyzes the conversion of pyruvate to acetaldehyde and CO2 in alcoholic fermentation. IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway in plants and various plant-associated bacteria, it catalyzes the decarboxylation of IPA to IAA. This subfamily also includes the large catalytic subunit of acetohydroxyacid synthase (AHAS). AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate, a precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. Methanococcus jannaschii sulfopyruvate decarboxylase (MjComDE) and phosphonopyruvate decarboxylase (PpyrDc) also belong to this subfamily. PpyrDc is a homotrimeric enzyme having the PP and PYR domains tandemly arranged on the same subunit. It functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus. MjComDE is a dodecamer having the PYR and PP domains on different subunits, it has six alpha (PYR/ComD) subunits and six beta (PP/ComE) subunits. MjComDE catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway.


Pssm-ID: 132918 [Multi-domain]  Cd Length: 155  Bit Score: 112.24  E-value: 7.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   7 EQLVDVLIDWHVKHVYGLPGDSIDTTVDALRKqqDQIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNGL 86
Cdd:cd07035     1 DALVEALKAEGVDHVFGVPGGAILPLLDALAR--SGIRYILVRHEQGAVGMADGYARATGKPGVVLVTSGPGLTNAVTGL 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1586112881  87 YDAKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAY-EKHGVAVLTIP 161
Cdd:cd07035    79 ANAYLDSIPLLVITGQRPTAGEGRGAFQEIDQVALFRPITKWAYRVTSPEEIPEALRRAFRIALsGRPGPVALDLP 154
PRK05858 PRK05858
acetolactate synthase;
18-530 6.87e-28

acetolactate synthase;


Pssm-ID: 235629 [Multi-domain]  Cd Length: 542  Bit Score: 117.90  E-value: 6.87e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  18 VKHVYGLPGDSIDTTVDALRKQQdqIGFVQVRHEEVASLAAAAEAKLTGKLGVCLSIGGPGAIHILNGLYDAKMDHVPVL 97
Cdd:PRK05858   20 VDTMFTLSGGHLFPLYDGAREEG--IRLIDVRHEQTAAFAAEAWAKLTRVPGVAVLTAGPGVTNGMSAMAAAQFNQSPLV 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  98 ALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKH-GVAVLTIPdnlpeqrvSDHYISS 176
Cdd:PRK05858   98 VLGGRAPALRWGMGSLQEIDHVPFVAPVTKFAATAQSAENAGRLVDQALQAAVTPHrGPVFVDFP--------MDHAFSM 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 177 ASSFQLTSPQI--------DDNRLNTAAKLIRDSKKPLALVG--LGAKKAGSQVAAFLEQNHIPFISTLPAKGIIGDNHP 246
Cdd:PRK05858  170 ADDDGRPGALTelpagptpDPDALARAAGLLAEAQRPVIMAGtdVWWGHAEAALLRLAEELGIPVLMNGMGRGVVPADHP 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 247 nslgnvgKLGTKPAYEAMQNTDLLLMFGTNYPYT-AYLPKPGRAKSIQINTSASAIGKRYPADVGLVADIkdvikqlnss 325
Cdd:PRK05858  250 -------LAFSRARGKALGEADVVLVVGVPMDFRlGFGVFGGTAQLVHVDDAPPQRAHHRPVAAGLYGDL---------- 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 326 eTTILhpdDGFLKACQENVAnWNRWMTGKREL--------------DSKPVAPEALFNDINETAPHNTIYSIDVGTATSW 391
Cdd:PRK05858  313 -SAIL---SALAGAGGDRTD-HQGWIEELRTAetaarardaaeladDRDPIHPMRVYGELAPLLDRDAIVIGDGGDFVSY 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 392 SARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFI 471
Cdd:PRK05858  388 AGRYIDPYRPGCWLDPGPFGCLGTGPGYALAARLARPSRQVVLLQGDGAFGFSLMDVDTLVRHNLPVVSVIGNNGIWGLE 467
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 472 EYEQQAAGQLNYQIDLQ-DMDYAKFADAAGGVGITAKTSEEFKNALNRAYrVQNMPVLIN 530
Cdd:PRK05858  468 KHPMEALYGYDVAADLRpGTRYDEVVRALGGHGELVTVPAELGPALERAF-ASGVPYLVN 526
TPP_BFDC cd02002
Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins ...
364-533 1.21e-25

Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This enzyme is dependent on TPP and a divalent metal cation as cofactors.


Pssm-ID: 238960 [Multi-domain]  Cd Length: 178  Bit Score: 103.83  E-value: 1.21e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 364 PEALFNDINETAPHNTIYSIDvgtATSWSARFLNVSPTQKFilSSYLGT----MGCALPGAIAAKINYPDRPVISVNGDG 439
Cdd:cd02002     3 PEYLAAALAAALPEDAIIVDE---AVTNGLPLRDQLPLTRP--GSYFTLrgggLGWGLPAAVGAALANPDRKVVAIIGDG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 440 AFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQLN------YQIDLQD--MDYAKFADAAGGVGITAKTSEE 511
Cdd:cd02002    78 SFMYTIQALWTAARYGLPVTVVILNNRGYGALRSFLKRVGPEGpgenapDGLDLLDpgIDFAAIAKAFGVEAERVETPEE 157
                         170       180
                  ....*....|....*....|..
gi 1586112881 512 FKNALNRAYRVQNmPVLINAYV 533
Cdd:cd02002   158 LDEALREALAEGG-PALIEVVV 178
PRK08327 PRK08327
thiamine pyrophosphate-requiring protein;
65-522 1.72e-24

thiamine pyrophosphate-requiring protein;


Pssm-ID: 236243 [Multi-domain]  Cd Length: 569  Bit Score: 107.78  E-value: 1.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  65 TGKLGVCLSIGGPGAIHILNGLYDAKMDHVPVLALLGQvdTQFLNE----------EYFQEV-NTPQLFADVAVYNKLIS 133
Cdd:PRK08327   73 TGKPQAVMVHVDVGTANALGGVHNAARSRIPVLVFAGR--SPYTEEgelgsrntriHWTQEMrDQGGLVREYVKWDYEIR 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 134 ATDNLAEIVDEAIRTAY-EKHGVAVLTIPDNLPEQRVSDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLALVG-L 211
Cdd:PRK08327  151 RGDQIGEVVARAIQIAMsEPKGPVYLTLPREVLAEEVPEVKADAGRQMAPAPPAPDPEDIARAAEMLAAAERPVIITWrA 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 212 GAKKAGSQVAAFLEQNH-IPFISTLPAKGIIGDNHPNSLGNVGKlgtkpayEAMQNTDLLLMFGTNYPYT-AYLPKPGRA 289
Cdd:PRK08327  231 GRTAEGFASLRRLAEELaIPVVEYAGEVVNYPSDHPLHLGPDPR-------ADLAEADLVLVVDSDVPWIpKKIRPDADA 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 290 KSIQINT--SASAIGKR-YPADVGLVADIKDVIKQLNSSETTILHPDDGFLKACQENVA-NWNRWMTGKREL-----DSK 360
Cdd:PRK08327  304 RVIQIDVdpLKSRIPLWgFPCDLCIQADTSTALDQLEERLKSLASAERRRARRRRAAVReLRIRQEAAKRAEierlkDRG 383
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 361 PVAPEALFNDINETAP-HNTIYSiDVGTaTSWSARFlnVSPTQKFILSSYlGTMGCALPGAIAAKINYPDRPVISVNGDG 439
Cdd:PRK08327  384 PITPAYLSYCLGEVADeYDAIVT-EYPF-VPRQARL--NKPGSYFGDGSA-GGLGWALGAALGAKLATPDRLVIATVGDG 458
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 440 AFA--------MVMQdfitavKYKLPLINIVLNN-----SKLAFIE-YEQQAAGQLNY--QIDLQ-DMDYAKFADAAGGV 502
Cdd:PRK08327  459 SFIfgvpeaahWVAE------RYGLPVLVVVFNNggwlaVKEAVLEvYPEGYAARKGTfpGTDFDpRPDFAKIAEAFGGY 532
                         490       500
                  ....*....|....*....|
gi 1586112881 503 GITAKTSEEFKNALNRAYRV 522
Cdd:PRK08327  533 GERVEDPEELKGALRRALAA 552
TPP_Xsc_like cd02013
Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of ...
361-524 7.01e-24

Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the desulfonation of 2-sulfoacetaldehyde into sulfite and acetyl phosphate. This enzyme requires TPP and divalent metal ions for activity.


Pssm-ID: 238971 [Multi-domain]  Cd Length: 196  Bit Score: 99.51  E-value: 7.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 361 PVAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGA 440
Cdd:cd02013     3 PMHPRQVLRELEKAMPEDAIVSTDIGNICSVANSYLRFEKPRSFIAPLSFGNCGYALPAIIGAKAAAPDRPVVAIAGDGA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 441 FAMVMQDFITAVKYKLPLINIVLNNsklafieyeQQAAGQLNYQID----------LQDMDYAKFADAAGGVGITAKTSE 510
Cdd:cd02013    83 WGMSMMEIMTAVRHKLPVTAVVFRN---------RQWGAEKKNQVDfynnrfvgteLESESFAKIAEACGAKGITVDKPE 153
                         170
                  ....*....|....
gi 1586112881 511 EFKNALNRAYRVQN 524
Cdd:cd02013   154 DVGPALQKAIAMMA 167
TPP_enzyme_PYR cd06586
Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Thiamine ...
9-161 2.16e-22

Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Thiamine pyrophosphate (TPP) family, pyrimidine (PYR) binding domain; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this group. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. In the case of 2-oxoisovalerate dehydrogenase (2OXO), sulfopyruvate decarboxylase (ComDE), and the E1 component of human pyruvate dehydrogenase complex (E1- PDHc) the PYR and PP domains appear on different subunits. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. For many of these enzymes the active sites lie between PP and PYR domains on different subunits. However, for the homodimeric enzymes 1-deoxy-D-xylulose 5-phosphate synthase (DXS) and Desulfovibrio africanus pyruvate:ferredoxin oxidoreductase (PFOR), each active site lies at the interface of the PYR and PP domains from the same subunit.


Pssm-ID: 132915 [Multi-domain]  Cd Length: 154  Bit Score: 93.56  E-value: 2.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881   9 LVDVLIDWHVKHVYGLPGDSIDTTVDALRKQQDQIgFVQVRHEEVASLAAAAEAKLTGKlGVCLSIGGPGAIHILNGLYD 88
Cdd:cd06586     3 FAEVLTAWGVRHVFGYPGDEISSLLDALREGDKRI-IDTVIHELGAAGAAAGYARAGGP-PVVIVTSGTGLLNAINGLAD 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1586112881  89 AKMDHVPVLALLGQVDTQFLNEEYFQEVNTPQLFADVAVYNKLISATDNLAEIVDEAIRTAYEKHGVAVLTIP 161
Cdd:cd06586    81 AAAEHLPVVFLIGARGISAQAKQTFQSMFDLGMYRSIPEANISSPSPAELPAGIDHAIRTAYASQGPVVVRLP 153
TPP_PDC_IPDC cd02005
Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of ...
385-538 5.10e-20

Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize other 2-oxo acids as substrates. In plants and various plant-associated bacteria, IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway, a tryptophan-dependent biosynthetic route to indole-3-acetaldehyde (IAA). IPDC catalyzes the decarboxylation of IPA to IAA. Both PDC and IPDC depend on TPP and Mg2+ as cofactors.


Pssm-ID: 238963 [Multi-domain]  Cd Length: 183  Bit Score: 87.97  E-value: 5.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 385 VGTATSWSARFLNVSPTQ-KFILSSYLGTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVL 463
Cdd:cd02005    23 AETGTSWFGALDLKLPKGtRFISQPLWGSIGYSVPAALGAALAAPDRRVILLVGDGSFQMTVQELSTMIRYGLNPIIFLI 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 464 NNSK---LAFIEYEQQAagqlnYQiDLQDMDYAK----FADAAGGVGITAKTSEEFKNALNRAYRVQNMPVLINAYVS-D 535
Cdd:cd02005   103 NNDGytiERAIHGPEAS-----YN-DIANWNYTKlpevFGGGGGGLSFRVKTEGELDEALKDALFNRDKLSLIEVILPkD 176

                  ...
gi 1586112881 536 DAP 538
Cdd:cd02005   177 DAP 179
TPP_Gcl cd02006
Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins ...
357-531 2.45e-17

Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the condensation of two molecules of glyoxylate to give tartronic semialdehyde and carbon dioxide. This enzyme requires TPP, magnesium ion and FAD as cofactors.


Pssm-ID: 238964 [Multi-domain]  Cd Length: 202  Bit Score: 80.79  E-value: 2.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 357 LDSKPVAPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFILSSYLGTMGCALPGAIAAKINYPDRPVISVN 436
Cdd:cd02006     3 FDDVPIKPQRVYEEMNKAFGRDVRYVTTIGLSQIAGAQMLHVYKPRHWINCGQAGPLGWTVPAALGVAAADPDRQVVALS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 437 GDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEyEQQAAGQLNYQIDLQ------------DMDYAKFADAAGGVGI 504
Cdd:cd02006    83 GDYDFQFMIEELAVGAQHRIPYIHVLVNNAYLGLIR-QAQRAFDMDYQVNLAfeninsselggyGVDHVKVAEGLGCKAI 161
                         170       180       190
                  ....*....|....*....|....*....|
gi 1586112881 505 TAKTSEEFKNALNRAYRV---QNMPVLINA 531
Cdd:cd02006   162 RVTKPEELAAAFEQAKKLmaeHRVPVVVEA 191
TPP_IolD cd02003
Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins ...
412-529 2.85e-16

Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism.


Pssm-ID: 238961 [Multi-domain]  Cd Length: 205  Bit Score: 77.73  E-value: 2.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 412 TMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFI--------------EYEQQA 477
Cdd:cd02003    49 CMGYEIAAGLGAKLAKPDREVYVLVGDGSYLMLHSEIVTAVQEGLKIIIVLFDNHGFGCInnlqestgsgsfgtEFRDRD 128
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1586112881 478 AGQLNYQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAyRVQNMPVLI 529
Cdd:cd02003   129 QESGQLDGALLPVDFAANARSLGARVEKVKTIEELKAALAKA-KASDRTTVI 179
PRK07092 PRK07092
benzoylformate decarboxylase; Reviewed
262-533 4.46e-14

benzoylformate decarboxylase; Reviewed


Pssm-ID: 235931 [Multi-domain]  Cd Length: 530  Bit Score: 74.99  E-value: 4.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 262 EAMQNTDLLLMFGTN-YPYTAYLPK---PGRAKSIQInTSASAIGKRYPADVGLVADIKDVIKQLNSSETTILHPDdgfL 337
Cdd:PRK07092  268 ALLDGHDLVLVIGAPvFTYHVEGPGphlPEGAELVQL-TDDPGEAAWAPMGDAIVGDIRLALRDLLALLPPSARPA---P 343
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 338 KAcqenvanwnRWMTGKRELDSKPVAPEALFNDINETAPHNTIYsidVGTATSWSA---RFLNVS-PTQKFILSSylGTM 413
Cdd:PRK07092  344 PA---------RPMPPPAPAPGEPLSVAFVLQTLAALRPADAIV---VEEAPSTRPamqEHLPMRrQGSFYTMAS--GGL 409
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 414 GCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIeyeQQAAGQLNYQ----IDLQD 489
Cdd:PRK07092  410 GYGLPAAVGVALAQPGRRVIGLIGDGSAMYSIQALWSAAQLKLPVTFVILNNGRYGAL---RWFAPVFGVRdvpgLDLPG 486
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1586112881 490 MDYAKFADAAGGVGITAKTSEEFKNALNRAYRvQNMPVLINAYV 533
Cdd:PRK07092  487 LDFVALARGYGCEAVRVSDAAELADALARALA-ADGPVLVEVEV 529
PRK07586 PRK07586
acetolactate synthase large subunit;
76-533 1.77e-11

acetolactate synthase large subunit;


Pssm-ID: 236063 [Multi-domain]  Cd Length: 514  Bit Score: 66.79  E-value: 1.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  76 GPGAIHILNGLYDAKMDHVPVLALLGQVDTqflneeYFQEVNTPqLFAD-------VAVYNKLISATDNLAEIVDEAIRT 148
Cdd:PRK07586   73 GPGLANGLANLHNARRARTPIVNIVGDHAT------YHRKYDAP-LTSDiealarpVSGWVRRSESAADVAADAAAAVAA 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 149 AYEKHG-VAVLTIPdnlpeqrvSDHYISSASSF-----QLTSPQIDDNRLNTAAKLIRDSKKPLALVGLGAKKAGSQVAA 222
Cdd:PRK07586  146 ARGAPGqVATLILP--------ADVAWSEGGPPappppAPAPAAVDPAAVEAAAAALRSGEPTVLLLGGRALRERGLAAA 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 223 -----------FLEqnhipfisTLPAKGIIGDNHPNslgnVGKLG--TKPAYEAMQNTDLLLMFGTNYP--YTAYLPKPG 287
Cdd:PRK07586  218 ariaaatgarlLAE--------TFPARMERGAGRPA----VERLPyfAEQALAQLAGVRHLVLVGAKAPvaFFAYPGKPS 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 288 RaksiqintsasaigkrypadvgLVADIKDVIkqlnssetTILHPDD----------GFLKACQEN--VANWNRWMTGKR 355
Cdd:PRK07586  286 R----------------------LVPEGCEVH--------TLAGPGEdaaaalealaDALGAKPAAppLAAPARPPLPTG 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 356 ELDskpvaPEALFNDINETAPHNTIYSIDVGTATSWSARFLNVSPTQKFiLSSYLGTMGCALPGAIAAKINYPDRPVISV 435
Cdd:PRK07586  336 ALT-----PEAIAQVIAALLPENAIVVDESITSGRGFFPATAGAAPHDW-LTLTGGAIGQGLPLATGAAVACPDRKVLAL 409
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 436 NGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAGQLNY------QIDLQD--MDYAKFADAAGGVGITAK 507
Cdd:PRK07586  410 QGDGSAMYTIQALWTQARENLDVTTVIFANRAYAILRGELARVGAGNPgpraldMLDLDDpdLDWVALAEGMGVPARRVT 489
                         490       500
                  ....*....|....*....|....*.
gi 1586112881 508 TSEEFKNALNRAYRVQNmPVLINAYV 533
Cdd:PRK07586  490 TAEEFADALAAALAEPG-PHLIEAVV 514
PRK12474 PRK12474
hypothetical protein; Provisional
411-533 1.91e-10

hypothetical protein; Provisional


Pssm-ID: 139002 [Multi-domain]  Cd Length: 518  Bit Score: 63.35  E-value: 1.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 411 GTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAFIEYEQQAAG--------QLN 482
Cdd:PRK12474  389 GSIGQGLPLAAGAAVAAPDRKVVCPQGDGGAAYTMQALWTMARENLDVTVVIFANRSYAILNGELQRVGaqgagrnaLSM 468
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1586112881 483 YQIDLQDMDYAKFADAAGGVGITAKTSEEFKNALNRAYrVQNMPVLINAYV 533
Cdd:PRK12474  469 LDLHNPELNWMKIAEGLGVEASRATTAEEFSAQYAAAM-AQRGPRLIEAMI 518
Ppyr-DeCO2ase TIGR03297
phosphonopyruvate decarboxylase; This family consists of examples of phosphonopyruvate an ...
411-538 4.89e-07

phosphonopyruvate decarboxylase; This family consists of examples of phosphonopyruvate an decarboxylase enzyme that produces phosphonoacetaldehyde (Pald), the second step in the biosynthesis phosphonate-containing compounds. Since the preceding enzymate step, PEP phosphomutase (AepX, TIGR02320) favors the substrate PEP energetically, the decarboxylase is required to drive the reaction in the direction of phosphonate production. Pald is a precursor of natural products including antibiotics like bialaphos and phosphonothricin in Streptomyces species, phosphonate-modified molecules such as the polysaccharide B of Bacteroides fragilis, the phosphonolipids of Tetrahymena pyroformis, the glycosylinositolphospholipids of Trypanosoma cruzi. This gene generally occurs in prokaryotic organisms adjacent to the gene for AepX. Most often an aminotansferase (aepZ) is also present which leads to the production of the most common phosphonate compound, 2-aminoethylphosphonate (AEP).


Pssm-ID: 274508 [Multi-domain]  Cd Length: 361  Bit Score: 51.97  E-value: 4.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 411 GTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLP-LINIVLNNsklafiEYEQQAAGQLNYQidlQD 489
Cdd:TIGR03297 221 GSMGHASQIALGLALARPDQRVVCLDGDGAALMHMGGLATIGTQGPAnLIHVLFNN------GAHDSVGGQPTVS---QH 291
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1586112881 490 MDYAKFADAAG-GVGITAKTSEEFKNALNRAYRVQNmPVLINAYVSDDAP 538
Cdd:TIGR03297 292 LDFAQIAKACGyAKVYEVSTLEELETALTAASSANG-PRLIEVKVRPGSR 340
TPP_PpyrDC cd03371
Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of ...
411-465 1.80e-06

Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus. These proteins require TPP and divalent metal cation cofactors.


Pssm-ID: 239468 [Multi-domain]  Cd Length: 188  Bit Score: 48.46  E-value: 1.80e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1586112881 411 GTMGCALPGAIAAKINYPDRPVISVNGDGAFAMVMQDFITAVKYKLP-LINIVLNN 465
Cdd:cd03371    48 GSMGHASQIALGIALARPDRKVVCIDGDGAALMHMGGLATIGGLAPAnLIHIVLNN 103
PLN02573 PLN02573
pyruvate decarboxylase
66-519 1.03e-04

pyruvate decarboxylase


Pssm-ID: 215311 [Multi-domain]  Cd Length: 578  Bit Score: 45.08  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881  66 GKLGVCLSIGGpgaIHILNGLYDAKMDHVPVLALLGQVDTQ------FLNE-----EYFQEVntpQLFADVAVYNKLISA 134
Cdd:PLN02573   80 GACVVTFTVGG---LSVLNAIAGAYSENLPVICIVGGPNSNdygtnrILHHtiglpDFSQEL---RCFQTVTCYQAVINN 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 135 TDNLAEIVDEAIRTAYEKHGVAVLTIPDNL---PEQRVSDHYISSASSFQLTSPQIDDNRLNTAAKLIRDSKKPLaLVG- 210
Cdd:PLN02573  154 LEDAHELIDTAISTALKESKPVYISVSCNLaaiPHPTFSREPVPFFLTPRLSNKMSLEAAVEAAAEFLNKAVKPV-LVGg 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 211 --LGAKKAGSQVAAFLEQNHIPFISTLPAKGIIGDNHPNSLGNV-GKLGTKPAYEAMQNTDLLLMFG---TNYPYTAY-- 282
Cdd:PLN02573  233 pkLRVAKACKAFVELADASGYPVAVMPSAKGLVPEHHPHFIGTYwGAVSTPFCAEIVESADAYLFAGpifNDYSSVGYsl 312
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 283 LPKPgrAKSIQINTSASAIGKRyPAdVGLVAdIKDVIKQLNSSettilhpddgfLKACQENVANWNRWMTGKRE-LDSKP 361
Cdd:PLN02573  313 LLKK--EKAIIVQPDRVTIGNG-PA-FGCVL-MKDFLEALAKR-----------VKKNTTAYENYKRIFVPEGEpLKSEP 376
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 362 VAP---EALFNDINETAPHNTiySIDVGTATSWsarfLNvspTQKFILSSylgtmGCALP-----GAI----AAKINY-- 427
Cdd:PLN02573  377 GEPlrvNVLFKHIQKMLSGDT--AVIAETGDSW----FN---CQKLKLPE-----GCGYEfqmqyGSIgwsvGATLGYaq 442
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 428 --PDRPVISVNGDGAFAMVMQDFITAVKYKLPLINIVLNNSKLAfIEYEQQaAGQLNYqidLQDMDYAKFADA-AGGVG- 503
Cdd:PLN02573  443 aaPDKRVIACIGDGSFQVTAQDVSTMIRCGQKSIIFLINNGGYT-IEVEIH-DGPYNV---IKNWNYTGLVDAiHNGEGk 517
                         490
                  ....*....|....*....
gi 1586112881 504 -ITAK--TSEEFKNALNRA 519
Cdd:PLN02573  518 cWTAKvrTEEELIEAIATA 536
TPP_ComE_PpyrDC cd02001
Thiamine pyrophosphate (TPP) family, ComE and PpyrDC subfamily, TPP-binding module; composed ...
410-519 1.82e-03

Thiamine pyrophosphate (TPP) family, ComE and PpyrDC subfamily, TPP-binding module; composed of proteins similar to sulfopyruvate decarboxylase beta subunit (ComE) and phosphonopyruvate decarboxylase (Ppyr decarboxylase). Methanococcus jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six alpha (D) subunits and six (E) beta subunits which, catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway. Ppyr decarboxylase is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus. Ppyr decarboxylase and ComDE require TPP and divalent metal cation cofactors.


Pssm-ID: 238959 [Multi-domain]  Cd Length: 157  Bit Score: 39.39  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586112881 410 LGTMGCALPGAIAAKINYPdRPVISVNGDGAFAMVMQDFITAVKYK-LPLINIVLNNSKLAfieyeqQAAGQLNYQIdlq 488
Cdd:cd02001    41 LGSMGLAGSIGLGLALGLS-RKVIVVDGDGSLLMNPGVLLTAGEFTpLNLILVVLDNRAYG------STGGQPTPSS--- 110
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1586112881 489 DMDYAKFADAAGGVGITAKTSEEFKNALNRA 519
Cdd:cd02001   111 NVNLEAWAAACGYLVLSAPLLGGLGSEFAGL 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH