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Conserved domains on  [gi|1686100022|gb|QDC26982|]
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translation superoxide dismutase, partial [Streptococcus pseudopneumoniae]

Protein Classification

superoxide dismutase( domain architecture ID 11427369)

Mn/Fe superoxide dismutase eliminates superoxide radicals by catalyzing their conversion into hydrogen peroxide and oxygen

CATH:  1.10.287.990
EC:  1.15.1.1
Gene Ontology:  GO:0046872|GO:0004784|GO:0006801
PubMed:  3345848|3315461

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
1-136 1.29e-63

Superoxide dismutase [Inorganic ion transport and metabolism];


:

Pssm-ID: 440370 [Multi-domain]  Cd Length: 192  Bit Score: 192.27  E-value: 1.29e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEI-GEDLEALLADvesIPADIRQALINNGGGHLNHALFWELMTPE-KTAPSAELAAAID 78
Cdd:COG0605    24 HHDKHHQAYVNNLNAALEGLAELeDKSLEEIIKK---LSEELKRALRNNAGGHWNHTLFWENLSPNgGGEPTGELAAAIE 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1686100022  79 ATFGSLEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPILGL 136
Cdd:COG0605   101 ADFGSFDAFKEEFKAAAAGRFGSGWAWLVVDKDGKLEIVSTPNQDNPLMAGGTPLLGL 158
 
Name Accession Description Interval E-value
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
1-136 1.29e-63

Superoxide dismutase [Inorganic ion transport and metabolism];


Pssm-ID: 440370 [Multi-domain]  Cd Length: 192  Bit Score: 192.27  E-value: 1.29e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEI-GEDLEALLADvesIPADIRQALINNGGGHLNHALFWELMTPE-KTAPSAELAAAID 78
Cdd:COG0605    24 HHDKHHQAYVNNLNAALEGLAELeDKSLEEIIKK---LSEELKRALRNNAGGHWNHTLFWENLSPNgGGEPTGELAAAIE 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1686100022  79 ATFGSLEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPILGL 136
Cdd:COG0605   101 ADFGSFDAFKEEFKAAAAGRFGSGWAWLVVDKDGKLEIVSTPNQDNPLMAGGTPLLGL 158
PRK10925 PRK10925
superoxide dismutase [Mn];
1-136 1.34e-43

superoxide dismutase [Mn];


Pssm-ID: 182843  Cd Length: 206  Bit Score: 141.98  E-value: 1.34e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEIGE-DLEALLADVESIPADIRQALINNGGGHLNHALFWELMTpEKTAPSAELAAAIDA 79
Cdd:PRK10925   27 HHTKHHQTYVNNANAALESLPEFANlPVEELITKLDQLPADKKTVLRNNAGGHANHSLFWKGLK-KGTTLQGDLKAAIER 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1686100022  80 TFGSLEEFQAAFTAAATTRFGSGWAWLVVnKEGKLEVTSTANQDTPI------SEGKKPILGL 136
Cdd:PRK10925  106 DFGSVDNFKAEFEKAAATRFGSGWAWLVL-KGDKLAVVSTANQDSPLmgeaisGASGFPILGL 167
Sod_Fe_C pfam02777
Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze ...
 69-136 3.33e-29

Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.


Pssm-ID: 460691  Cd Length: 102  Bit Score: 102.12  E-value: 3.33e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1686100022  69 PSAELAAAIDATFGSLEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPILGL 136
Cdd:pfam02777   1 PTGALAEAIEKDFGSFDAFKEEFNAAAAGVFGSGWAWLVYDPDGKLEIVTTPNQDNPLTDGLTPLLGL 68
Superox_dis_Halo NF041312
superoxide dismutase;
1-136 1.75e-16

superoxide dismutase;


Pssm-ID: 469209  Cd Length: 196  Bit Score: 71.77  E-value: 1.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEkhpEIGEDLEAllADVESIPADIRQaLINNGGGHLNHALFWELMTPEKTA-PSAELAAAIDA 79
Cdd:NF041312   24 HHDTHHQGYVNGLNSAEE---TLAENREA--GDFSSTAGAMRN-VTHNGSGHYLHTLFWENMSPNGGGePEGDLADRIEE 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1686100022  80 TFGSLEEFQAAFTAAATTrfGSGWAWLVVNKEGK-LEVTSTANQDTPISEGKKPILGL 136
Cdd:NF041312   98 DFGSYEAWKGEFEAAAGA--AGGWALLVYDPVAKqLRNVAVDKHDQGALWGSHPILAL 153
 
Name Accession Description Interval E-value
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
1-136 1.29e-63

Superoxide dismutase [Inorganic ion transport and metabolism];


Pssm-ID: 440370 [Multi-domain]  Cd Length: 192  Bit Score: 192.27  E-value: 1.29e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEI-GEDLEALLADvesIPADIRQALINNGGGHLNHALFWELMTPE-KTAPSAELAAAID 78
Cdd:COG0605    24 HHDKHHQAYVNNLNAALEGLAELeDKSLEEIIKK---LSEELKRALRNNAGGHWNHTLFWENLSPNgGGEPTGELAAAIE 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1686100022  79 ATFGSLEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPILGL 136
Cdd:COG0605   101 ADFGSFDAFKEEFKAAAAGRFGSGWAWLVVDKDGKLEIVSTPNQDNPLMAGGTPLLGL 158
PRK10925 PRK10925
superoxide dismutase [Mn];
1-136 1.34e-43

superoxide dismutase [Mn];


Pssm-ID: 182843  Cd Length: 206  Bit Score: 141.98  E-value: 1.34e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEIGE-DLEALLADVESIPADIRQALINNGGGHLNHALFWELMTpEKTAPSAELAAAIDA 79
Cdd:PRK10925   27 HHTKHHQTYVNNANAALESLPEFANlPVEELITKLDQLPADKKTVLRNNAGGHANHSLFWKGLK-KGTTLQGDLKAAIER 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1686100022  80 TFGSLEEFQAAFTAAATTRFGSGWAWLVVnKEGKLEVTSTANQDTPI------SEGKKPILGL 136
Cdd:PRK10925  106 DFGSVDNFKAEFEKAAATRFGSGWAWLVL-KGDKLAVVSTANQDSPLmgeaisGASGFPILGL 167
Sod_Fe_C pfam02777
Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze ...
 69-136 3.33e-29

Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.


Pssm-ID: 460691  Cd Length: 102  Bit Score: 102.12  E-value: 3.33e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1686100022  69 PSAELAAAIDATFGSLEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPILGL 136
Cdd:pfam02777   1 PTGALAEAIEKDFGSFDAFKEEFNAAAAGVFGSGWAWLVYDPDGKLEIVTTPNQDNPLTDGLTPLLGL 68
PLN02471 PLN02471
superoxide dismutase [Mn]
 1-136 3.53e-26

superoxide dismutase [Mn]


Pssm-ID: 215262  Cd Length: 231  Bit Score: 98.06  E-value: 3.53e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEIGEDLEAlladveSIPADIRQALINNGGGHLNHALFWELMTPEKTA----PSAELAAA 76
Cdd:PLN02471   55 HHQKHHQTYVTNYNKALEQLDQAVEKGDA------SAVVKLQSAIKFNGGGHVNHSIFWKNLAPVSEGggepPHGSLGWA 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1686100022  77 IDATFGSLEEFQAAFTAAATTRFGSGWAWLVVNKEG-KLEVTSTANQDTPISEGKK--PILGL 136
Cdd:PLN02471  129 IDEHFGSLEALVKKMSAEGAAVQGSGWVWLGLDKELkKLVVETTANQDPLVTKGPSlvPLLGI 191
PRK10543 PRK10543
superoxide dismutase [Fe];
1-134 2.66e-25

superoxide dismutase [Fe];


Pssm-ID: 182534  Cd Length: 193  Bit Score: 94.63  E-value: 2.66e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEIGEDLEALLADVESipadirqALINNGGGHLNHALFWELMTPEKTA-PSAELAAAIDA 79
Cdd:PRK10543   27 HYGKHHQTYVTNLNNLIKGTAFEGKSLEEIVRSSEG-------GVFNNAAQVWNHTFYWNCLAPNAGGePTGKVAEAIAA 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1686100022  80 TFGSLEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPIL 134
Cdd:PRK10543  100 SFGSFADFKAQFTDAAIKNFGSGWTWLVKNADGKLAIVSTSNAGTPLTTDATPLL 154
PTZ00078 PTZ00078
Superoxide dismutase [Fe]; Provisional
 1-136 6.97e-23

Superoxide dismutase [Fe]; Provisional


Pssm-ID: 185432 [Multi-domain]  Cd Length: 193  Bit Score: 88.69  E-value: 6.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEIGEDLEALLADVESipadirqALINNGGGHLNHALFWELMTPEKTA-PSAELAAAIDA 79
Cdd:PTZ00078   22 HYSKHHAGYVNKLNGLIKGTPLENKTLEELIKEYSG-------AVFNNAAQIWNHNFYWLSMGPNGGGePTGEIKEKIDE 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1686100022  80 TFGSLEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGK-KPILGL 136
Cdd:PTZ00078   95 KFGSFDNFKNEFSNVLSGHFGSGWGWLVLKNDGKLEIVQTHDAGNPIKDNTgKPLLTC 152
Sod_Fe_N pfam00081
Iron/manganese superoxide dismutases, alpha-hairpin domain; superoxide dismutases (SODs) ...
 1-63 4.99e-20

Iron/manganese superoxide dismutases, alpha-hairpin domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. N-terminal domain is a long alpha antiparallel hairpin. A small fragment of YTRE_LEPBI matches well - sequencing error?


Pssm-ID: 425457  Cd Length: 82  Bit Score: 78.12  E-value: 4.99e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEIGEDLEalladvESIPADIRQALINNGGGHLNHALFWELMT 63
Cdd:pfam00081  26 HHTKHHQTYVNNLNAALEGLEEARKPLE------ELIIKALLGGLFNNGGGHWNHSLFWKNLS 82
PLN02685 PLN02685
iron superoxide dismutase
 1-131 5.74e-19

iron superoxide dismutase


Pssm-ID: 215369  Cd Length: 299  Bit Score: 80.43  E-value: 5.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALekhpeIGEDLEAL-LADVESIPADIRQAL--INNGGGHLNHALFWELMTPEKTA-PSAELAAA 76
Cdd:PLN02685   71 HWGKHHRAYVDNLNKQI-----VGTELDGMsLEDVVLITYNKGDMLpaFNNAAQAWNHEFFWESMKPGGGGkPSGELLQL 145

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1686100022  77 IDATFGSLEEFQAAFTAAATTRFGSGWAWLVVnKEGKLEVTSTANQdTPISEGKK 131
Cdd:PLN02685  146 IERDFGSFERFVEEFKSAAATQFGSGWAWLAY-KANRLDVGNAVNP-CPSEEDKK 198
PLN02622 PLN02622
iron superoxide dismutase
 1-136 1.23e-17

iron superoxide dismutase


Pssm-ID: 166263 [Multi-domain]  Cd Length: 261  Bit Score: 76.20  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEI-GEDLEALLA----DVESIPAdirqalINNGGGHLNHALFWELMTPEK-TAPSAELA 74
Cdd:PLN02622   72 HWGEHHRGYVEGLNKQLAKDDILyGYTMDELVKvtynNGNPLPE------FNNAAQVWNHDFFWESMQPGGgDMPELGVL 145

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1686100022  75 AAIDATFGSLEEFQAAFTAAATTRFGSGWAWLVVNK-EGKLEVTSTANQDTPISEGKKPILGL 136
Cdd:PLN02622  146 EQIEKDFGSFTNFREKFTEAALTLFGSGWVWLVLKReERRLEVVKTSNAINPLVWDDIPIICL 208
Superox_dis_Halo NF041312
superoxide dismutase;
1-136 1.75e-16

superoxide dismutase;


Pssm-ID: 469209  Cd Length: 196  Bit Score: 71.77  E-value: 1.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEkhpEIGEDLEAllADVESIPADIRQaLINNGGGHLNHALFWELMTPEKTA-PSAELAAAIDA 79
Cdd:NF041312   24 HHDTHHQGYVNGLNSAEE---TLAENREA--GDFSSTAGAMRN-VTHNGSGHYLHTLFWENMSPNGGGePEGDLADRIEE 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1686100022  80 TFGSLEEFQAAFTAAATTrfGSGWAWLVVNKEGK-LEVTSTANQDTPISEGKKPILGL 136
Cdd:NF041312   98 DFGSYEAWKGEFEAAAGA--AGGWALLVYDPVAKqLRNVAVDKHDQGALWGSHPILAL 153
PLN02184 PLN02184
superoxide dismutase [Fe]
 1-134 2.36e-14

superoxide dismutase [Fe]


Pssm-ID: 177838  Cd Length: 212  Bit Score: 66.69  E-value: 2.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1686100022   1 HHDKHHQTYVNNANAALEKHPEIGEDLEALLADV----ESIPAdirqalINNGGGHLNHALFWELMTPEKTA-PSAELAA 75
Cdd:PLN02184   35 HWGKHHRAYVDNLKKQVLGTELEGKPLEHIIHSTynngDLLPA------FNNAAQAWNHEFFWESMKPGGGGkPSGELLA 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1686100022  76 AIDATFGSLEEFQAAFTAAATTRFGSGWAWLVVNKEgKLEVTSTANQDTPISEGKKPIL 134
Cdd:PLN02184  109 LLERDFTSYEKFYEEFNAAAATQFGAGWAWLAYSNE-KLKVVKTPNAVNPLVLGSFPLL 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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