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Conserved domains on  [gi|1702100899|gb|QDK70558|]
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helix-turn-helix transcriptional regulator [Lactococcus protaetiae]

Protein Classification

PadR family transcriptional regulator( domain architecture ID 10507796)

PadR family transcriptional regulator similar to Lactococcus lactis LmrR which belongs to the PadR-like family of transcriptional regulators, a transcriptional repressor of lmrCD expression and an autoregulator of its own expression.

Gene Ontology:  GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 17-90 2.12e-29

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


:

Pssm-ID: 397561  Cd Length: 74  Bit Score: 100.78  E-value: 2.12e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1702100899  17 LLNVLEQGDNYVYGIIKQVREASNGEFELNEATLYTIFRRLEKDGIITSYWGDETQGGRRKYYRLTDIGRENMQ 90
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGGFWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGRRELA 74
 
Name Accession Description Interval E-value
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 17-90 2.12e-29

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 100.78  E-value: 2.12e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1702100899  17 LLNVLEQGDNYVYGIIKQVREASNGEFELNEATLYTIFRRLEKDGIITSYWGDETQGGRRKYYRLTDIGRENMQ 90
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGGFWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGRRELA 74
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
4-105 4.45e-28

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 98.08  E-value: 4.45e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702100899   4 IPREMLRAQANVILLNVLEQGDNYVYGIIKQVREASNGEFELNEATLYTIFRRLEKDGIITSYWGDETQGGRRKYYRLTD 83
Cdd:COG1695     1 MKRQLRKGTLELLILALLAEGPMYGYEIIKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTE 80

                          90       100
                  ....*....|....*....|..
gi 1702100899  84 IGRENMQLAFESWAKVDQIIEN 105
Cdd:COG1695    81 AGREELAEWLEEWEKLAEALEA 102
padR_acidobact TIGR03433
transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are ...
 18-106 4.28e-15

transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions]


Pssm-ID: 163261  Cd Length: 100  Bit Score: 64.88  E-value: 4.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702100899  18 LNVLEQGDNYVYGIIKQVREASNGEFELNEATLYTIFRRLEKDGIITSYWGdETQGGRR-KYYRLTDIGRENMQLAFESW 96
Cdd:TIGR03433  10 LKTLSLGPLHGYGIAQRIQQISEDVLQVEEGSLYPALHRLERRGWIAAEWG-ESENNRRaKFYRLTAAGRKQLAAETESW 88

                          90
                  ....*....|
gi 1702100899  97 AKVDQIIENI 106
Cdd:TIGR03433  89 ARLSAAIARV 98
lstR PRK09416
PadR family transcriptional regulator;
6-86 2.55e-08

PadR family transcriptional regulator;


Pssm-ID: 181836  Cd Length: 135  Bit Score: 48.25  E-value: 2.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702100899   6 REMLRAQANV---ILLNVLE--QGDNYVYGIIKQVREASNGEFELNEATLYTIFRRLEKDGIITSYWGDETQggrrKYYR 80
Cdd:PRK09416   31 REKIKQSSEKeedILLAILQllMNEKTGYELLQLLRQRGILTFEGNEGSLYTLLHRLEQNRFIQSSWDHEGA----KYYQ 106


                  ....*.
gi 1702100899  81 LTDIGR 86
Cdd:PRK09416  107 LTDKGN 112
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 42-86 1.09e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 1.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1702100899  42 EFELNEATLYTIFRRLEKDGIITSYwgdetQGGRRKYYRLTDIGR 86
Cdd:cd00090    29 RLGLSQSTVSRHLKKLEEAGLVESR-----REGRRVYYSLTDAER 68
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
36-83 1.68e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.11  E-value: 1.68e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1702100899   36 REASNGE----FELNEATLYTIFRRLEKDGIITSYwgdetQGGRRKYYRLTD 83
Cdd:smart00418   9 GELCVCElaeiLGLSQSTVSHHLKKLREAGLVESR-----REGKRVYYSLTD 55
 
Name Accession Description Interval E-value
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 17-90 2.12e-29

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 100.78  E-value: 2.12e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1702100899  17 LLNVLEQGDNYVYGIIKQVREASNGEFELNEATLYTIFRRLEKDGIITSYWGDETQGGRRKYYRLTDIGRENMQ 90
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGGFWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGRRELA 74
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
4-105 4.45e-28

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 98.08  E-value: 4.45e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702100899   4 IPREMLRAQANVILLNVLEQGDNYVYGIIKQVREASNGEFELNEATLYTIFRRLEKDGIITSYWGDETQGGRRKYYRLTD 83
Cdd:COG1695     1 MKRQLRKGTLELLILALLAEGPMYGYEIIKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTE 80

                          90       100
                  ....*....|....*....|..
gi 1702100899  84 IGRENMQLAFESWAKVDQIIEN 105
Cdd:COG1695    81 AGREELAEWLEEWEKLAEALEA 102
padR_acidobact TIGR03433
transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are ...
 18-106 4.28e-15

transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions]


Pssm-ID: 163261  Cd Length: 100  Bit Score: 64.88  E-value: 4.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702100899  18 LNVLEQGDNYVYGIIKQVREASNGEFELNEATLYTIFRRLEKDGIITSYWGdETQGGRR-KYYRLTDIGRENMQLAFESW 96
Cdd:TIGR03433  10 LKTLSLGPLHGYGIAQRIQQISEDVLQVEEGSLYPALHRLERRGWIAAEWG-ESENNRRaKFYRLTAAGRKQLAAETESW 88

                          90
                  ....*....|
gi 1702100899  97 AKVDQIIENI 106
Cdd:TIGR03433  89 ARLSAAIARV 98
lstR PRK09416
PadR family transcriptional regulator;
6-86 2.55e-08

PadR family transcriptional regulator;


Pssm-ID: 181836  Cd Length: 135  Bit Score: 48.25  E-value: 2.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702100899   6 REMLRAQANV---ILLNVLE--QGDNYVYGIIKQVREASNGEFELNEATLYTIFRRLEKDGIITSYWGDETQggrrKYYR 80
Cdd:PRK09416   31 REKIKQSSEKeedILLAILQllMNEKTGYELLQLLRQRGILTFEGNEGSLYTLLHRLEQNRFIQSSWDHEGA----KYYQ 106


                  ....*.
gi 1702100899  81 LTDIGR 86
Cdd:PRK09416  107 LTDKGN 112
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
42-83 4.30e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 36.94  E-value: 4.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1702100899  42 EFELNEATLYTIFRRLEKDGIITSYWGDETQGGRRKYYRLTD 83
Cdd:COG1777    39 ELGVSRQAVYKHLRKLEEAGLVESYREGREDGRARKYYRLSA 80
PaaX_trns_reg TIGR02277
phenylacetic acid degradation operon negative regulatory protein PaaX; This transcriptional ...
 42-92 4.88e-04

phenylacetic acid degradation operon negative regulatory protein PaaX; This transcriptional regulator is always found in association with operons believed to be involved in the degradation of phenylacetic acid. The gene product has been shown to bind to the promoter sites and repress their transcription. [Regulatory functions, DNA interactions]


Pssm-ID: 274064 [Multi-domain]  Cd Length: 280  Bit Score: 37.87  E-value: 4.88e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1702100899  42 EFELNEATLYTIFRRLEKDGiitsyWGDETQGGRRKYYRLTDIGRENMQLA 92
Cdd:TIGR02277  29 GLGINERLVRTAVSRLVAQG-----WLQSERKGRRSFYSLTDKGRRRFAAA 74
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 42-86 1.09e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 1.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1702100899  42 EFELNEATLYTIFRRLEKDGIITSYwgdetQGGRRKYYRLTDIGR 86
Cdd:cd00090    29 RLGLSQSTVSRHLKKLEEAGLVESR-----REGRRVYYSLTDAER 68
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
36-83 1.68e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.11  E-value: 1.68e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1702100899   36 REASNGE----FELNEATLYTIFRRLEKDGIITSYwgdetQGGRRKYYRLTD 83
Cdd:smart00418   9 GELCVCElaeiLGLSQSTVSHHLKKLREAGLVESR-----REGKRVYYSLTD 55
PaaX COG3327
DNA-binding transcriptional regulator PaaX (phenylacetic acid degradation) [Transcription];
41-94 9.03e-03

DNA-binding transcriptional regulator PaaX (phenylacetic acid degradation) [Transcription];


Pssm-ID: 442556 [Multi-domain]  Cd Length: 281  Bit Score: 34.11  E-value: 9.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1702100899  41 GEFELNEATLYTIFRRLEKDGIITSywgdeTQGGRRKYYRLTDIGRENMQLAFE 94
Cdd:COG3327    45 EPLGVSERAVRTALSRLVKRGWLES-----ERRGRRSGYRLTPRGRRRLEEGDR 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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