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Conserved domains on  [gi|1704624178|gb|QDM07207|]
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antirestriction protein ArdA (plasmid) [Escherichia coli]

Protein Classification

antirestriction protein ArdA( domain architecture ID 10008776)

antirestriction protein ArdA allows associated mobile genetic elements to evade the ubiquitous Type I DNA restriction systems, assisting in the spread of resistance genes in bacteria

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
5-166 4.98e-50

Antirestriction protein ArdA [Defense mechanisms];


:

Pssm-ID: 443768  Cd Length: 173  Bit Score: 158.56  E-value: 4.98e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704624178   5 APAVYVGTWHKYNCGSIAGRWFDLTtfDDERDFFAACRALHQD---EADPELMFQDYEGFPGNMASECHINWAWVEGFRL 81
Cdd:COG4734     7 TPRIYVACLAAYNNGSLHGKWIDAT--QDVEEIQEAIREMLADspvEDAEEWAIHDYEGFPGATISEYESLEKVFELAEF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704624178  82 ARDEGceEAYRLWVEDTG--ETDFDTFRDAWWGEADSEEAFAVEFASDTGLLADVPETVALYFDYEAYARDLFLDSFTFI 159
Cdd:COG4734    85 IEEHG--EAFAAWLDHFGglEDAEEAFEDAYQGEYDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFLSDYVTV 162

                         170
                  ....*....|.
gi 1704624178 160 DG----HVFRR 166
Cdd:COG4734   163 EGgfevHVFWN 173
 
Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
5-166 4.98e-50

Antirestriction protein ArdA [Defense mechanisms];


Pssm-ID: 443768  Cd Length: 173  Bit Score: 158.56  E-value: 4.98e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704624178   5 APAVYVGTWHKYNCGSIAGRWFDLTtfDDERDFFAACRALHQD---EADPELMFQDYEGFPGNMASECHINWAWVEGFRL 81
Cdd:COG4734     7 TPRIYVACLAAYNNGSLHGKWIDAT--QDVEEIQEAIREMLADspvEDAEEWAIHDYEGFPGATISEYESLEKVFELAEF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704624178  82 ARDEGceEAYRLWVEDTG--ETDFDTFRDAWWGEADSEEAFAVEFASDTGLLADVPETVALYFDYEAYARDLFLDSFTFI 159
Cdd:COG4734    85 IEEHG--EAFAAWLDHFGglEDAEEAFEDAYQGEYDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFLSDYVTV 162

                         170
                  ....*....|.
gi 1704624178 160 DG----HVFRR 166
Cdd:COG4734   163 EGgfevHVFWN 173
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 8-164 8.24e-26

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


Pssm-ID: 462130  Cd Length: 151  Bit Score: 95.77  E-value: 8.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704624178   8 VYVGTWHKYNCGSIAGRWFDLTTfdDERDFFAACRALHQD-EADPELMFQDYEGFPGNMASECHInwawvegfrlarDEG 86
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLPA--DAEELQEALRRIGAEgEEYEEYAIHDYEGFGFTLGEYESI------------DEL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704624178  87 CEEAYRLwvEDTGETDFDTFRDA----WWGEADSEE---AFAVEFASDTGLLADVPETVALYFDYEAYARDLFLD--SFT 157
Cdd:pfam07275  67 NELAALL--EELAEHDLEEFEAAfeerYAGEYDSLIqnlDYAYYYVEELGELDEIPEELENYFDYEAYGRDLFLDgdGVF 144


                  ....*..
gi 1704624178 158 FIDGHVF 164
Cdd:pfam07275 145 TETGYVE 151
 
Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
5-166 4.98e-50

Antirestriction protein ArdA [Defense mechanisms];


Pssm-ID: 443768  Cd Length: 173  Bit Score: 158.56  E-value: 4.98e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704624178   5 APAVYVGTWHKYNCGSIAGRWFDLTtfDDERDFFAACRALHQD---EADPELMFQDYEGFPGNMASECHINWAWVEGFRL 81
Cdd:COG4734     7 TPRIYVACLAAYNNGSLHGKWIDAT--QDVEEIQEAIREMLADspvEDAEEWAIHDYEGFPGATISEYESLEKVFELAEF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704624178  82 ARDEGceEAYRLWVEDTG--ETDFDTFRDAWWGEADSEEAFAVEFASDTGLLADVPETVALYFDYEAYARDLFLDSFTFI 159
Cdd:COG4734    85 IEEHG--EAFAAWLDHFGglEDAEEAFEDAYQGEYDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFLSDYVTV 162

                         170
                  ....*....|.
gi 1704624178 160 DG----HVFRR 166
Cdd:COG4734   163 EGgfevHVFWN 173
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 8-164 8.24e-26

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


Pssm-ID: 462130  Cd Length: 151  Bit Score: 95.77  E-value: 8.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704624178   8 VYVGTWHKYNCGSIAGRWFDLTTfdDERDFFAACRALHQD-EADPELMFQDYEGFPGNMASECHInwawvegfrlarDEG 86
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLPA--DAEELQEALRRIGAEgEEYEEYAIHDYEGFGFTLGEYESI------------DEL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704624178  87 CEEAYRLwvEDTGETDFDTFRDA----WWGEADSEE---AFAVEFASDTGLLADVPETVALYFDYEAYARDLFLD--SFT 157
Cdd:pfam07275  67 NELAALL--EELAEHDLEEFEAAfeerYAGEYDSLIqnlDYAYYYVEELGELDEIPEELENYFDYEAYGRDLFLDgdGVF 144


                  ....*..
gi 1704624178 158 FIDGHVF 164
Cdd:pfam07275 145 TETGYVE 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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