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Conserved domains on  [gi|1727596665|gb|QEG95195|]
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ATPase, AAA family (plasmid) [Escherichia coli]

Protein Classification

ATP-binding protein( domain architecture ID 1000207)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase

CATH:  3.40.50.300
Gene Ontology:  GO:0005524
PubMed:  15037234|18466635|16689629
SCOP:  3002019

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPT1 super family cl34191
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 191-388 2.16e-22

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG1222:

Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 97.00  E-value: 2.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 191 DFYTRYGQSGMRKVLFTGPPGTGKTTIAKAL------------GAKYQDKY----------VFvyaddyfkdvcyAAAQK 248
Cdd:COG1222   102 ELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVagelgapfirvrGSELVSKYigegarnvreVF------------ELARE 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 249 KIPVIIIAEEVDEL--YRADAGT-----------LSFLDGADtPRNlaGTYVIFSTNYPNRIDPRIRkRPGRIDRIISVG 315
Cdd:COG1222   170 KAPSIIFIDEIDAIaaRRTDDGTsgevqrtvnqlLAELDGFE-SRG--DVLIIAATNRPDLLDPALL-RPGRFDRVIEVP 245

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1727596665 316 AFRTKAAAACAKMYL---PDDINIDLKELGAVLDRTTPAEIKEIINIAiGM--IRGTKNELTVDVIKNARAFLKGTLD 388
Cdd:COG1222   246 LPDEEAREEILKIHLrdmPLADDVDLDKLAKLTEGFSGADLKAIVTEA-GMfaIREGRDTVTMEDLEKAIEKVKKKTE 322
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 191-388 2.16e-22

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 97.00  E-value: 2.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 191 DFYTRYGQSGMRKVLFTGPPGTGKTTIAKAL------------GAKYQDKY----------VFvyaddyfkdvcyAAAQK 248
Cdd:COG1222   102 ELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVagelgapfirvrGSELVSKYigegarnvreVF------------ELARE 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 249 KIPVIIIAEEVDEL--YRADAGT-----------LSFLDGADtPRNlaGTYVIFSTNYPNRIDPRIRkRPGRIDRIISVG 315
Cdd:COG1222   170 KAPSIIFIDEIDAIaaRRTDDGTsgevqrtvnqlLAELDGFE-SRG--DVLIIAATNRPDLLDPALL-RPGRFDRVIEVP 245

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1727596665 316 AFRTKAAAACAKMYL---PDDINIDLKELGAVLDRTTPAEIKEIINIAiGM--IRGTKNELTVDVIKNARAFLKGTLD 388
Cdd:COG1222   246 LPDEEAREEILKIHLrdmPLADDVDLDKLAKLTEGFSGADLKAIVTEA-GMfaIREGRDTVTMEDLEKAIEKVKKKTE 322
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 195-314 6.92e-16

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 74.63  E-value: 6.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 195 RYGQSGMRKVLFTGPPGTGKTTIAKAL------------GAKYQDKYVFVYAD---DYFKDvcyaaAQKKIPVIIIAEEV 259
Cdd:cd19481    20 RYGLGLPKGILLYGPPGTGKTLLAKALagelglplivvkLSSLLSKYVGESEKnlrKIFER-----ARRLAPCILFIDEI 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1727596665 260 DEL-----YRADAGT--------LSFLDGadtPRNLAGTYVIFSTNYPNRIDPRIRkRPGRIDRIISV 314
Cdd:cd19481    95 DAIgrkrdSSGESGElrrvlnqlLTELDG---VNSRSKVLVIAATNRPDLLDPALL-RPGRFDEVIEF 158
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 204-315 4.72e-15

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 71.47  E-value: 4.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKALGAKYQDKYVFV--------YADDYFKDV--CYAAAQKKIPVIIIAEEVDELYRADAGT---- 269
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEIsgselvskYVGESEKRLreLFEAAKKLAPCVIFIDEIDALAGSRGSGgdse 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1727596665 270 --------LSFLDGADtpRNLAGTYVIFSTNYPNRIDPRIRkrpGRIDRIISVG 315
Cdd:pfam00004  81 srrvvnqlLTELDGFT--SSNSKVIVIAATNRPDKLDPALL---GRFDRIIEFP 129
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 204-374 9.61e-13

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 69.09  E-value: 9.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKAL------------GAKYQDKYV-----FVyaddyfKDVcYAAAQKKIPVIIIAEEVDEL--YR 264
Cdd:PRK03992  168 VLLYGPPGTGKTLLAKAVahetnatfirvvGSELVQKFIgegarLV------REL-FELAREKAPSIIFIDEIDAIaaKR 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 265 ADAGT-------------LSFLDGADtprNLAGTYVIFSTNYPNRIDPRIRkRPGRIDRIISVGAFRTKAAAA-----CA 326
Cdd:PRK03992  241 TDSGTsgdrevqrtlmqlLAEMDGFD---PRGNVKIIAATNRIDILDPAIL-RPGRFDRIIEVPLPDEEGRLEilkihTR 316

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1727596665 327 KMYLPDDinIDLKELGAVLDRTTPAEIKEIINIAiGM--IRGTKNELTVD 374
Cdd:PRK03992  317 KMNLADD--VDLEELAELTEGASGADLKAICTEA-GMfaIRDDRTEVTME 363
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 202-361 2.52e-11

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 65.70  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 202 RKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYADDYFKD----------VCYAAAQKKIPVIIIAEEVDELYRA---DAG 268
Cdd:TIGR01243 488 KGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKwvgesekairEIFRKARQAAPAIIFFDEIDAIAPArgaRFD 567

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 269 T----------LSFLDGADTPRNLAgtyVIFSTNYPNRIDPRIRkRPGRIDRIISVGAFRTKAAAACAK-----MYLPDD 333
Cdd:TIGR01243 568 TsvtdrivnqlLTEMDGIQELSNVV---VIAATNRPDILDPALL-RPGRFDRLILVPPPDEEARKEIFKihtrsMPLAED 643

                         170       180
                  ....*....|....*....|....*...
gi 1727596665 334 inIDLKELGAVLDRTTPAEIKEIINIAI 361
Cdd:TIGR01243 644 --VDLEELAEMTEGYTGADIEAVCREAA 669
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 202-312 4.11e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 49.29  E-value: 4.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665  202 RKVLFTGPPGTGKTTIAKALGAKYQDKYVFVY---ADDYFKDVCY------------------------AAAQKKIPVII 254
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGVIyidGEDILEEVLDqllliivggkkasgsgelrlrlalALARKLKPDVL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1727596665  255 IAEEVDEL----YRADAGTLSFLDGADTPRNLAGTYVIFSTNYPNRIDPRIRKRpgRIDRII 312
Cdd:smart00382  83 ILDEITSLldaeQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR--RFDRRI 142
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 204-224 1.18e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 40.15  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|.
gi 1727596665 204 VLFTGPPGTGKTTIAKALGAK 224
Cdd:NF038214   93 VLLLGPPGTGKTHLAIALGYA 113
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 191-388 2.16e-22

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 97.00  E-value: 2.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 191 DFYTRYGQSGMRKVLFTGPPGTGKTTIAKAL------------GAKYQDKY----------VFvyaddyfkdvcyAAAQK 248
Cdd:COG1222   102 ELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVagelgapfirvrGSELVSKYigegarnvreVF------------ELARE 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 249 KIPVIIIAEEVDEL--YRADAGT-----------LSFLDGADtPRNlaGTYVIFSTNYPNRIDPRIRkRPGRIDRIISVG 315
Cdd:COG1222   170 KAPSIIFIDEIDAIaaRRTDDGTsgevqrtvnqlLAELDGFE-SRG--DVLIIAATNRPDLLDPALL-RPGRFDRVIEVP 245

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1727596665 316 AFRTKAAAACAKMYL---PDDINIDLKELGAVLDRTTPAEIKEIINIAiGM--IRGTKNELTVDVIKNARAFLKGTLD 388
Cdd:COG1222   246 LPDEEAREEILKIHLrdmPLADDVDLDKLAKLTEGFSGADLKAIVTEA-GMfaIREGRDTVTMEDLEKAIEKVKKKTE 322
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 178-379 1.32e-16

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 81.11  E-value: 1.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 178 ELENDFNQFFSDIDFYTRYGQSGMRKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYADD----YF-------KDVCyAAA 246
Cdd:COG0464   168 ELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDlvskYVgeteknlREVF-DKA 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 247 QKKIPVIIIAEEVDELYRADAGT------------LSFLDGADTPrnlagTYVIFSTNYPNRIDP---RirkrpgRIDRI 311
Cdd:COG0464   247 RGLAPCVLFIDEADALAGKRGEVgdgvgrrvvntlLTEMEELRSD-----VVVIAATNRPDLLDPallR------RFDEI 315

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1727596665 312 ISVGAFRTKAAAACAKMYLPD---DINIDLKELGAVLDRTTPAEIKEIINIAI-GMIRGTKNELTVDVIKNA 379
Cdd:COG0464   316 IFFPLPDAEERLEIFRIHLRKrplDEDVDLEELAEATEGLSGADIRNVVRRAAlQALRLGREPVTTEDLLEA 387
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 195-314 6.92e-16

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 74.63  E-value: 6.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 195 RYGQSGMRKVLFTGPPGTGKTTIAKAL------------GAKYQDKYVFVYAD---DYFKDvcyaaAQKKIPVIIIAEEV 259
Cdd:cd19481    20 RYGLGLPKGILLYGPPGTGKTLLAKALagelglplivvkLSSLLSKYVGESEKnlrKIFER-----ARRLAPCILFIDEI 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1727596665 260 DEL-----YRADAGT--------LSFLDGadtPRNLAGTYVIFSTNYPNRIDPRIRkRPGRIDRIISV 314
Cdd:cd19481    95 DAIgrkrdSSGESGElrrvlnqlLTELDG---VNSRSKVLVIAATNRPDLLDPALL-RPGRFDEVIEF 158
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 191-314 2.87e-15

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 72.93  E-value: 2.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 191 DFYTRYGQSGMRKVLFTGPPGTGKTTIAKALGAKYQDKYV-----------FVYADDYFKDVcYAAAQKKIPVIIIAEEV 259
Cdd:cd19528    17 DKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFIsvkgpelltmwFGESEANVRDI-FDKARAAAPCVLFFDEL 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 260 DELYRADAGT---------------LSFLDGADTPRNLagtYVIFSTNYPNRIDPRIrKRPGRIDRIISV 314
Cdd:cd19528    96 DSIAKARGGNigdaggaadrvinqiLTEMDGMNTKKNV---FIIGATNRPDIIDPAI-LRPGRLDQLIYI 161
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 204-315 4.72e-15

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 71.47  E-value: 4.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKALGAKYQDKYVFV--------YADDYFKDV--CYAAAQKKIPVIIIAEEVDELYRADAGT---- 269
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEIsgselvskYVGESEKRLreLFEAAKKLAPCVIFIDEIDALAGSRGSGgdse 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1727596665 270 --------LSFLDGADtpRNLAGTYVIFSTNYPNRIDPRIRkrpGRIDRIISVG 315
Cdd:pfam00004  81 srrvvnqlLTELDGFT--SSNSKVIVIAATNRPDKLDPALL---GRFDRIIEFP 129
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 193-312 8.85e-15

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 71.55  E-value: 8.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 193 YTRYGQSGMRKVLFTGPPGTGKTTIAKALgAKYQDKYVFV---------YADDYFKDV--CYAAAQKKIPVIIIAEEVDE 261
Cdd:cd19503    26 FRALGLKPPRGVLLHGPPGTGKTLLARAV-ANEAGANFLSisgpsivskYLGESEKNLreIFEEARSHAPSIIFIDEIDA 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1727596665 262 L------------YRADAGTLSFLDGADtprNLAGTYVIFSTNYPNRIDPRIRkRPGRIDRII 312
Cdd:cd19503   105 LapkreedqreveRRVVAQLLTLMDGMS---SRGKVVVIAATNRPDAIDPALR-RPGRFDREV 163
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 191-314 1.81e-14

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 70.78  E-value: 1.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 191 DFYTRYGQSGMRKVLFTGPPGTGKTTIAKAL------------GAKYQDKYVFvYADDYFKDVcYAAAQKKIPVIIIAEE 258
Cdd:cd19511    17 DAFKRLGIRPPKGVLLYGPPGCGKTLLAKALaseaglnfisvkGPELFSKYVG-ESERAVREI-FQKARQAAPCIIFFDE 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1727596665 259 VDELY-------------RADAGTLSFLDGADTPRnlaGTYVIFSTNYPNRIDPRIRkRPGRIDRIISV 314
Cdd:cd19511    95 IDSLAprrgqsdssgvtdRVVSQLLTELDGIESLK---GVVVIAATNRPDMIDPALL-RPGRLDKLIYV 159
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 204-374 9.61e-13

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 69.09  E-value: 9.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKAL------------GAKYQDKYV-----FVyaddyfKDVcYAAAQKKIPVIIIAEEVDEL--YR 264
Cdd:PRK03992  168 VLLYGPPGTGKTLLAKAVahetnatfirvvGSELVQKFIgegarLV------REL-FELAREKAPSIIFIDEIDAIaaKR 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 265 ADAGT-------------LSFLDGADtprNLAGTYVIFSTNYPNRIDPRIRkRPGRIDRIISVGAFRTKAAAA-----CA 326
Cdd:PRK03992  241 TDSGTsgdrevqrtlmqlLAEMDGFD---PRGNVKIIAATNRIDILDPAIL-RPGRFDRIIEVPLPDEEGRLEilkihTR 316

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1727596665 327 KMYLPDDinIDLKELGAVLDRTTPAEIKEIINIAiGM--IRGTKNELTVD 374
Cdd:PRK03992  317 KMNLADD--VDLEELAELTEGASGADLKAICTEA-GMfaIRDDRTEVTME 363
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 204-314 1.32e-12

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 65.44  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKAL------------GAKYQDKYVFVYAD---DYFKdvcyaAAQKKIPVIIIAEEVDEL--YRAD 266
Cdd:cd19502    40 VLLYGPPGTGKTLLAKAVanhtdatfirvvGSELVQKYIGEGARlvrELFE-----MAREKAPSIIFIDEIDAIgaKRFD 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1727596665 267 AGT-------------LSFLDGADTPRNLAgtyVIFSTNYPNRIDPRIRkRPGRIDRIISV 314
Cdd:cd19502   115 SGTggdrevqrtmlelLNQLDGFDPRGNIK---VIMATNRPDILDPALL-RPGRFDRKIEF 171
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
202-368 2.73e-12

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 68.52  E-value: 2.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 202 RKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYADDY-----------FKDVcYAAAQKKIPVIIIAEEVDELYRADAGTL 270
Cdd:PRK10733  186 KGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFvemfvgvgasrVRDM-FEQAKKAAPCIIFIDEIDAVGRQRGAGL 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 271 ------------SFLDGADTPRNLAGTYVIFSTNYPNRIDPRIRkRPGRIDRIISVGAFRTKAAAACAKMYL---PDDIN 335
Cdd:PRK10733  265 ggghdereqtlnQMLVEMDGFEGNEGIIVIAATNRPDVLDPALL-RPGRFDRQVVVGLPDVRGREQILKVHMrrvPLAPD 343

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1727596665 336 IDlkelGAVLDRTTP----AEIKEIIN-IAIGMIRGTK 368
Cdd:PRK10733  344 ID----AAIIARGTPgfsgADLANLVNeAALFAARGNK 377
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 193-315 3.22e-12

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 64.38  E-value: 3.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 193 YTRYGQSGMRKVLFTGPPGTGKTTIAKALgAKYQDKYVFV---------YADDYFKDV--CYAAAQKKIPVIIIAEEVDE 261
Cdd:cd19519    26 FKAIGIKPPRGILLYGPPGTGKTLIARAV-ANETGAFFFLingpeimskLAGESESNLrkAFEEAEKNAPAIIFIDEIDA 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1727596665 262 L------------YRADAGTLSFLDGADTPRNLAgtyVIFSTNYPNRIDPRIRkRPGRIDRIISVG 315
Cdd:cd19519   105 IapkrekthgeveRRIVSQLLTLMDGLKQRAHVI---VMAATNRPNSIDPALR-RFGRFDREIDIG 166
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 182-314 7.51e-12

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 63.14  E-value: 7.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 182 DFNQFFSDIDFYTRYGQSGMRKVLFTGPPGTGKTTIAKALgAKYQDKYVFVY-------ADDYFKDVCYAAAQKKipvII 254
Cdd:cd19510     4 DLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAAL-AGELDYDICDLnlsevvlTDDRLNHLLNTAPKQS---II 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1727596665 255 IAEEVD---ELYRADA---------------GTLSFLDGadtPRNLAGTYVIFSTNYPNRIDPRIrKRPGRIDRIISV 314
Cdd:cd19510    80 LLEDIDaafESREHNKknpsaygglsrvtfsGLLNALDG---VASSEERIVFMTTNHIERLDPAL-IRPGRVDMKIYM 153
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 178-314 8.19e-12

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 63.41  E-value: 8.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 178 ELEnDFNQFFSDIDFYTRYGQSGMRKVLFTGPPGTGKTTIAKAL------------GAKYQDKYVFVYAD---DYFKdvc 242
Cdd:cd19501    15 ELK-EVVEFLKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVageagvpffsisGSDFVEMFVGVGASrvrDLFE--- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 243 yaAAQKKIPVIIIAEEVDELYRADAGTLSF---------------LDGADTPrnlAGTYVIFSTNYPNRIDPRIRkRPGR 307
Cdd:cd19501    91 --QAKKNAPCIVFIDEIDAVGRKRGAGLGGghdereqtlnqllveMDGFESN---TGVIVIAATNRPDVLDPALL-RPGR 164


                  ....*..
gi 1727596665 308 IDRIISV 314
Cdd:cd19501   165 FDRQVYV 171
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 191-314 2.36e-11

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 61.74  E-value: 2.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 191 DFYTRYGQSGMRKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYADDYF--------KDV--CYAAAQKKIPVIIIAEEVD 260
Cdd:cd19529    17 EVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLskwvgeseKAIreIFRKARQVAPCVIFFDEID 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1727596665 261 ELYRADAGT-------------LSFLDGADTPRnlaGTYVIFSTNYPNRIDPRIRkRPGRIDRIISV 314
Cdd:cd19529    97 SIAPRRGTTgdsgvtervvnqlLTELDGLEEMN---GVVVIAATNRPDIIDPALL-RAGRFDRLIYI 159
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 202-361 2.52e-11

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 65.70  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 202 RKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYADDYFKD----------VCYAAAQKKIPVIIIAEEVDELYRA---DAG 268
Cdd:TIGR01243 488 KGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKwvgesekairEIFRKARQAAPAIIFFDEIDAIAPArgaRFD 567

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 269 T----------LSFLDGADTPRNLAgtyVIFSTNYPNRIDPRIRkRPGRIDRIISVGAFRTKAAAACAK-----MYLPDD 333
Cdd:TIGR01243 568 TsvtdrivnqlLTEMDGIQELSNVV---VIAATNRPDILDPALL-RPGRFDRLILVPPPDEEARKEIFKihtrsMPLAED 643

                         170       180
                  ....*....|....*....|....*...
gi 1727596665 334 inIDLKELGAVLDRTTPAEIKEIINIAI 361
Cdd:TIGR01243 644 --VDLEELAEMTEGYTGADIEAVCREAA 669
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 196-373 3.01e-11

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 64.78  E-value: 3.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 196 YGQSGM---RKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYADDY-----------FKDVcYAAAQKKIPVIIIAEEVDE 261
Cdd:PTZ00454  171 YEQIGIdppRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFvqkylgegprmVRDV-FRLARENAPSIIFIDEVDS 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 262 LY--RADAGT-------------LSFLDGADTPRNLAgtyVIFSTNYPNRIDPRIRkRPGRIDRIISVG---------AF 317
Cdd:PTZ00454  250 IAtkRFDAQTgadrevqrillelLNQMDGFDQTTNVK---VIMATNRADTLDPALL-RPGRLDRKIEFPlpdrrqkrlIF 325

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1727596665 318 RTkaaaACAKMYLPDDinIDLKELGAVLDRTTPAEIKEIINIAiGMIRGTKNELTV 373
Cdd:PTZ00454  326 QT----ITSKMNLSEE--VDLEDFVSRPEKISAADIAAICQEA-GMQAVRKNRYVI 374
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 204-315 7.23e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 60.24  E-value: 7.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKALG---AKYQDKYVFVYADDYFKDVCYA-------------AAQKKIPVIIIAEEVDELYRADA 267
Cdd:cd00009    22 LLLYGPPGTGKTTLARAIAnelFRPGAPFLYLNASDLLEGLVVAelfghflvrllfeLAEKAKPGVLFIDEIDSLSRGAQ 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1727596665 268 GTLS--FLDGADTPRNLAGTYVIFSTNYPNRIDPRiRKRPGRIDRIISVG 315
Cdd:cd00009   102 NALLrvLETLNDLRIDRENVRVIGATNRPLLGDLD-RALYDRLDIRIVIP 150
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 191-310 8.19e-11

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 60.60  E-value: 8.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 191 DFYTRYGQSGMRKVLFTGPPGTGKTTIAKALGA---KYQDKYVFVY---ADDYFKDV---------CYAAAQKKIPVIII 255
Cdd:cd19517    24 EVFAKFKITPPRGVLFHGPPGTGKTLMARALAAecsKGGQKVSFFMrkgADCLSKWVgeaerqlrlLFEEAYRMQPSIIF 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1727596665 256 AEEVDEL--YRAD----------AGTLSFLDGADtprNLAGTYVIFSTNYPNRIDPRIRkRPGRIDR 310
Cdd:cd19517   104 FDEIDGLapVRSSkqeqihasivSTLLALMDGLD---NRGQVVVIGATNRPDALDPALR-RPGRFDR 166
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 199-314 1.46e-10

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 59.45  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 199 SGMRK---VLFTGPPGTGKTTIAKALGAKYQDKYVFV--------YADDYFKDV--CYAAAQKKIPVIIIAEEVDELY-- 263
Cdd:cd19527    21 SGLRKrsgILLYGPPGTGKTLLAKAIATECSLNFLSVkgpelinmYIGESEANVreVFQKARDAKPCVIFFDELDSLAps 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1727596665 264 ---RADAG---------TLSFLDGADTPRNlaGTYVIFSTNYPNRIDPRIRkRPGRIDRIISV 314
Cdd:cd19527   101 rgnSGDSGgvmdrvvsqLLAELDGMSSSGQ--DVFVIGATNRPDLLDPALL-RPGRFDKLLYL 160
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 191-344 2.42e-10

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 62.62  E-value: 2.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 191 DFYTRYGQSGMRKVLFTGPPGTGKTTIAKAL------------GAKYQDKYVFvYADDYFKDVcYAAAQKKIPVIIIAEE 258
Cdd:TIGR01243 202 ELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVaneagayfisinGPEIMSKYYG-ESEERLREI-FKEAEENAPSIIFIDE 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 259 VDELY------------RADAGTLSFLDGAdtpRNLAGTYVIFSTNYPNRIDPRIRkRPGRIDRIISVGAFRTKAAAACA 326
Cdd:TIGR01243 280 IDAIApkreevtgevekRVVAQLLTLMDGL---KGRGRVIVIGATNRPDALDPALR-RPGRFDREIVIRVPDKRARKEIL 355

                         170       180
                  ....*....|....*....|.
gi 1727596665 327 KMY---LPDDINIDLKELGAV 344
Cdd:TIGR01243 356 KVHtrnMPLAEDVDLDKLAEV 376
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 191-314 5.94e-10

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 57.88  E-value: 5.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 191 DFYTRYGQSGMRKVLFTGPPGTGKTTIAKALGAKYQDKYVFV--------YADDYFKDV--CYAAAQKKIPVIIIAEEVD 260
Cdd:cd19530    20 DIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVkgpellnkYVGESERAVrqVFQRARASAPCVIFFDEVD 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1727596665 261 ELY--RADAGT----------LSFLDGADTPRNLagtYVIFSTNYPNRIDPRIRkRPGRIDRIISV 314
Cdd:cd19530   100 ALVpkRGDGGSwaservvnqlLTEMDGLEERSNV---FVIAATNRPDIIDPAML-RPGRLDKTLYV 161
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 191-356 8.83e-09

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 57.09  E-value: 8.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 191 DFYTRYGQSGMRKVLFTGPPGTGKTTIAKALGAKYQDKYVFV--------YADDYFKDV--CYAAAQKKIPVIIIAEEVD 260
Cdd:PTZ00361  207 ELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVvgseliqkYLGDGPKLVreLFRVAEENAPSIVFIDEID 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 261 EL----YRADAG-----------TLSFLDGADTPRNLAgtyVIFSTNYPNRIDPRIrKRPGRIDRIISVGAFRTKAAAA- 324
Cdd:PTZ00361  287 AIgtkrYDATSGgekeiqrtmleLLNQLDGFDSRGDVK---VIMATNRIESLDPAL-IRPGRIDRKIEFPNPDEKTKRRi 362

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1727596665 325 ----CAKMYLPDDinIDLKELGAVLDRTTPAEIKEI 356
Cdd:PTZ00361  363 feihTSKMTLAED--VDLEEFIMAKDELSGADIKAI 396
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
195-379 9.07e-09

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 55.66  E-value: 9.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 195 RYGQSGMRKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYAD----DYFKDvcyAAAQ--------KKIPVIIIAEEVDEL 262
Cdd:COG1223    29 KFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDsligSYLGE---TARNlrklfdfaRRAPCVIFFDEFDAI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 263 -----YRADAGTL-----SFLDGADTPRNlaGTYVIFSTNYPNRIDPRIRKrpgRIDRIISVGAFRTKAAAACAKMYL-- 330
Cdd:COG1223   106 akdrgDQNDVGEVkrvvnALLQELDGLPS--GSVVIAATNHPELLDSALWR---RFDEVIEFPLPDKEERKEILELNLkk 180

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1727596665 331 -PDDINIDLKELGAVLDRTTPAEIKEIINIAI-GMIRGTKNELTVDVIKNA 379
Cdd:COG1223   181 fPLPFELDLKKLAKKLEGLSGADIEKVLKTALkKAILEDREKVTKEDLEEA 231
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 202-304 2.30e-08

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 53.12  E-value: 2.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 202 RKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYADD----------YFKDVCYAAAQKKIPVIIIAEEVDELYRADAGT-- 269
Cdd:cd19509    33 RGILLYGPPGTGKTLLARAVASESGSTFFSISASSlvskwvgeseKIVRALFALARELQPSIIFIDEIDSLLSERGSGeh 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1727596665 270 ----------LSFLDGADTPRNlAGTYVIFSTNYPNRIDPRIRKR 304
Cdd:cd19509   113 easrrvktefLVQMDGVLNKPE-DRVLVLGATNRPWELDEAFLRR 156
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 202-304 3.86e-08

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 52.43  E-value: 3.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 202 RKVLFTGPPGTGKTTIAKAL----GAKYQDKYVFVYADDYF------KDVCYAAAQKKIPVIIIAEEVDELYRADAGT-- 269
Cdd:cd19520    36 KGVLLYGPPGCGKTMLAKATakeaGARFINLQVSSLTDKWYgesqklVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTdh 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1727596665 270 ----------LSFLDGADTPRNlAGTYVIFSTNYPNRIDPRIRKR 304
Cdd:cd19520   116 eatammkaefMSLWDGLSTDGN-CRVIVMGATNRPQDLDEAILRR 159
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 196-312 4.99e-08

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 52.05  E-value: 4.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 196 YGQSGMRK---VLFTGPPGTGKTTIAKAL------------GAKYQDKYVFVyADDYFKDVcYAAAQKKIPVIIIAEEVD 260
Cdd:cd19526    19 FASSPLRLrsgILLYGPPGCGKTLLASAIasecglnfisvkGPELLNKYIGA-SEQNVRDL-FSRAQSAKPCILFFDEFD 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1727596665 261 EL--YRADAGT----------LSFLDGADtprNLAGTYVIFSTNYPNRIDPRIRkRPGRIDRII 312
Cdd:cd19526    97 SIapKRGHDSTgvtdrvvnqlLTQLDGVE---GLDGVYVLAATSRPDLIDPALL-RPGRLDKLV 156
44 PHA02544
clamp loader, small subunit; Provisional
 205-350 5.53e-08

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 54.23  E-value: 5.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 205 LFTGPPGTGKTTIAKALGAKYQDKYVFVYADDYFKDV--------CYAAAQKKIPVIIIAEEVDELYRADAgtlsfldgA 276
Cdd:PHA02544   47 LHSPSPGTGKTTVAKALCNEVGAEVLFVNGSDCRIDFvrnrltrfASTVSLTGGGKVIIIDEFDRLGLADA--------Q 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 277 DTPRNLAGTY-----VIFSTNYPNRIDPRIRKR--------PGRIDRIISVGAFRTKAAAACAKmylpDDINIDLKELGA 343
Cdd:PHA02544  119 RHLRSFMEAYskncsFIITANNKNGIIEPLRSRcrvidfgvPTKEEQIEMMKQMIVRCKGILEA----EGVEVDMKVLAA 194


                  ....*..
gi 1727596665 344 VLDRTTP 350
Cdd:PHA02544  195 LVKKNFP 201
ftsH CHL00176
cell division protein; Validated
 186-315 2.68e-07

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 52.74  E-value: 2.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 186 FFSDIDFYTRYGQSGMRKVLFTGPPGTGKTTIAKAL------------GAKYQDKYVFVYA---DDYFKdvcyaAAQKKI 250
Cdd:CHL00176  201 FLKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIageaevpffsisGSEFVEMFVGVGAarvRDLFK-----KAKENS 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 251 PVIIIAEEVDELYR---ADAGT------------LSFLDGADtPRNlaGTYVIFSTNYPNRIDPRIRkRPGRIDRIISVG 315
Cdd:CHL00176  276 PCIVFIDEIDAVGRqrgAGIGGgndereqtlnqlLTEMDGFK-GNK--GVIVIAATNRVDILDAALL-RPGRFDRQITVS 351
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 202-314 2.90e-07

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 50.10  E-value: 2.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 202 RKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYADDYFKDVCyAAAQKKI-----------PVIIIAEEVDEL-------- 262
Cdd:cd19518    35 RGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVS-GESEEKIrelfdqaisnaPCIVFIDEIDAItpkresaq 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1727596665 263 ----YRADAGTLSFLDG-ADTPRNLAGTYVIFSTNYPNRIDPRIRkRPGRIDRIISV 314
Cdd:cd19518   114 remeRRIVSQLLTCMDElNNEKTAGGPVLVIGATNRPDSLDPALR-RAGRFDREICL 169
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 202-312 4.11e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 49.29  E-value: 4.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665  202 RKVLFTGPPGTGKTTIAKALGAKYQDKYVFVY---ADDYFKDVCY------------------------AAAQKKIPVII 254
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGVIyidGEDILEEVLDqllliivggkkasgsgelrlrlalALARKLKPDVL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1727596665  255 IAEEVDEL----YRADAGTLSFLDGADTPRNLAGTYVIFSTNYPNRIDPRIRKRpgRIDRII 312
Cdd:smart00382  83 ILDEITSLldaeQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR--RFDRRI 142
AAA_28 pfam13521
AAA domain;
203-274 5.26e-06

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 46.49  E-value: 5.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 203 KVLFTGPPGTGKTTIAKALGAKYqdKYVFV--YADDYFKD-------VCYAAAQK-KIPVIIIAEEVDELYRADAGTLSF 272
Cdd:pfam13521   1 RIVITGGPSTGKTTLAEALAARF--GYPVVpeAAREILEElgadggdALPWVEDLlAFARGVLEAQLEDEAAAAANDLLF 78


                  ..
gi 1727596665 273 LD 274
Cdd:pfam13521  79 FD 80
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 202-304 1.16e-05

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 45.75  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 202 RKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYAD----------DYFKDVCYAAAQKKIPVIIIAEEVDELY-------- 263
Cdd:cd19525    56 KGILLFGPPGTGKTLIGKCIASQSGATFFSISASsltskwvgegEKMVRALFSVARCKQPAVIFIDEIDSLLsqrgegeh 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1727596665 264 ----RADAGTLSFLDGADTPRNlAGTYVIFSTNYPNRIDPRIRKR 304
Cdd:cd19525   136 essrRIKTEFLVQLDGATTSSE-DRILVVGATNRPQEIDEAARRR 179
NadR3 COG3172
Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase ...
 201-237 2.19e-05

Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 442405 [Multi-domain]  Cd Length: 178  Bit Score: 44.81  E-value: 2.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1727596665 201 MRKVLFTGPPGTGKTTIAKALGAKYQdkYVFV--YADDY 237
Cdd:COG3172     8 VKKIVLLGAESTGKTTLARALAAHYN--TPWVpeYGREY 44
COG2842 COG2842
Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons]; ...
 162-386 7.76e-05

Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons];


Pssm-ID: 442090 [Multi-domain]  Cd Length: 254  Bit Score: 44.17  E-value: 7.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 162 EEIENALRFSVHPKFNELENdFNQFFSDIDFYTRYGQSGmrkvLFTGPPGTGKTTIAKALGAKYQDKY-----------V 230
Cdd:COG2842    16 EKLEAKIARWEAPSFVETKN-VRRFAEALDEARALPGIG----VVYGESGVGKTTAAREYANRNPNVIyvtaspswtskE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 231 FVY--------------ADDYFKDVCYAAAQKKIPVIIiaeevDELYRADAGTLSFL----DGADTPRNLAGTyvifstn 292
Cdd:COG2842    91 LLEelaeelgipappgtIADLRDRILERLAGTGRLLII-----DEADHLKPKALEELrdihDETGVGVVLIGM------- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 293 ypNRIDPRIRKRP---GRIDRIISVGAFRTKAAAACAKMYLpddiNIDLKELGAVLDRTTPAEIKEIIN----IAIGMIR 365
Cdd:COG2842   159 --ERLPAKLKRYEqlySRIGFWVEFKPLSLEDVRALAEAWG----ELTDPDLLELLHRITRGNLRRLDRtlrlAARAAKR 232

                         250       260
                  ....*....|....*....|.
gi 1727596665 366 GTKNELTVDVIKNARAFLKGT 386
Cdd:COG2842   233 NGLTKITLDHVRAAALMLGEG 253
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 204-266 8.99e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 44.76  E-value: 8.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTT----IAKALGAKYQDKYVFV-------YADD------------------YFKDVCY-AAAQKKIPVI 253
Cdd:COG1401   224 VILAGPPGTGKTYlarrLAEALGGEDNGRIEFVqfhpswsYEDFllgyrpsldegkyeptpgIFLRFCLkAEKNPDKPYV 303

                          90
                  ....*....|...
gi 1727596665 254 IIaeeVDELYRAD 266
Cdd:COG1401   304 LI---IDEINRAN 313
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
205-225 1.17e-04

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 44.03  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|.
gi 1727596665 205 LFTGPPGTGKTTIAKALgAKY 225
Cdd:COG2812    36 LFTGPRGVGKTTLARIL-AKA 55
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 204-304 1.43e-04

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 41.51  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKALGAKYQDKYVFVYA-------------------DDYFKDVCYAAAQKKIPVIIIaEEVDELYR 264
Cdd:pfam07728   2 VLLVGPPGTGKTELAERLAAALSNRPVFYVQltrdtteedlfgrrnidpgGASWVDGPLVRAAREGEIAVL-DEINRANP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1727596665 265 ADAGTL-SFLD---------GADTPRNLAGTYVIFSTNYP----NRIDPRIRKR 304
Cdd:pfam07728  81 DVLNSLlSLLDerrlllpdgGELVKAAPDGFRLIATMNPLdrglNELSPALRSR 134
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 204-261 2.47e-04

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 42.47  E-value: 2.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKALGAKYQDKYVFVY-------ADDYFKDVCYA------------------------AAQKKIPV 252
Cdd:COG3267    46 VVLTGEVGTGKTTLLRRLLERLPDDVKVAYipnpqlsPAELLRAIADElglepkgaskadllrqlqefllelAAAGRRVV 125


                  ....*....
gi 1727596665 253 IIIaeevDE 261
Cdd:COG3267   126 LII----DE 130
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
204-271 3.70e-04

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 41.69  E-value: 3.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1727596665 204 VLFTGPPGTGKTTIAKALGakyqdkyvfvyaddyfkdvcYAAAQKKIPVIII--AEEVDELYRA-DAGTLS 271
Cdd:COG1484   102 LILLGPPGTGKTHLAIALG--------------------HEACRAGYRVRFTtaPDLVNELKEArADGRLE 152
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 200-304 3.83e-04

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 41.12  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 200 GMRK----VLFTGPPGTGKTTIAKALGAKYQDKYVFV--------YADDYFKDV--CYAAAQKKIPVIIIAEEVDEL--- 262
Cdd:cd19522    28 GIRRpwkgVLMVGPPGTGKTLLAKAVATECGTTFFNVssstltskYRGESEKLVrlLFEMARFYAPTTIFIDEIDSIcsr 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1727596665 263 ----------YRADAGTLSFLDGA------DTPRNLagTYVIFSTNYPNRIDPRIRKR 304
Cdd:cd19522   108 rgtseeheasRRVKSELLVQMDGVggasenDDPSKM--VMVLAATNFPWDIDEALRRR 163
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 199-304 4.09e-04

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 41.00  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 199 SGMRK----VLFTGPPGTGKTTIAKALGAKYQDKYVFVYADDYF--------KDV--CYAAAQKKIPVIIIAEEVDEL-- 262
Cdd:cd19521    34 TGNRKpwsgILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVskwmgeseKLVkqLFAMARENKPSIIFIDEVDSLcg 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1727596665 263 YRADAGTLS-------FL-----DGADTprnlAGTYVIFSTNYPNRIDPRIRKR 304
Cdd:cd19521   114 TRGEGESEAsrrikteLLvqmngVGNDS----QGVLVLGATNIPWQLDSAIRRR 163
rfc PRK00440
replication factor C small subunit; Reviewed
 205-362 4.20e-04

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 42.17  E-value: 4.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 205 LFTGPPGTGKTTIAKAL-----GAKYQDKYVFVYADD---------YFKDVCYAAAQKKIPV-IIIAEEVDELyRADAGt 269
Cdd:PRK00440   42 LFAGPPGTGKTTAALALarelyGEDWRENFLELNASDergidvirnKIKEFARTAPVGGAPFkIIFLDEADNL-TSDAQ- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 270 lSFLdgadtpRNLAGTYV-----IFSTNYPNRIDPRI-------RKRP-------GRIDRI------------------I 312
Cdd:PRK00440  120 -QAL------RRTMEMYSqntrfILSCNYSSKIIDPIqsrcavfRFSPlkkeavaERLRYIaenegieitddaleaiyyV 192

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1727596665 313 SVGAFRT-----KAAAACAKmylpddiNIDLKELGAVLDRTTPAEIKEIINIAIG 362
Cdd:PRK00440  193 SEGDMRKainalQAAAATGK-------EVTEEAVYKITGTARPEEIREMIELALN 240
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 204-273 8.94e-04

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 40.92  E-value: 8.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKAL----GAKYQ------DK------YVFVYADD----YFKdvcyaaaqkKIPV---IIIAEEVD 260
Cdd:COG0714    34 LLLEGVPGVGKTTLAKALaralGLPFIriqftpDLlpsdilGTYIYDQQtgefEFR---------PGPLfanVLLADEIN 104

                          90
                  ....*....|...
gi 1727596665 261 elyRADAGTLSFL 273
Cdd:COG0714   105 ---RAPPKTQSAL 114
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 202-225 9.89e-04

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 41.37  E-value: 9.89e-04
                          10        20
                  ....*....|....*....|....
gi 1727596665 202 RKVLFTGPPGTGKTTIAKALGAKY 225
Cdd:TIGR03922 313 NHMLFAGPPGTGKTTIARVVAKIY 336
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 204-224 1.18e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 40.15  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|.
gi 1727596665 204 VLFTGPPGTGKTTIAKALGAK 224
Cdd:NF038214   93 VLLLGPPGTGKTHLAIALGYA 113
APSK cd02027
Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5 ...
 204-233 1.53e-03

Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of inorganic sulfate.


Pssm-ID: 238985 [Multi-domain]  Cd Length: 149  Bit Score: 39.00  E-value: 1.53e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKALGAKYQDKYVFVY 233
Cdd:cd02027     2 IWLTGLSGSGKSTIARALEEKLFQRGRPVY 31
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 194-277 1.70e-03

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 38.66  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 194 TRYGQSGMRKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYADDyfkdvcyAAAQKKIPVIIIAEEVDELYRADAGTLSFL 273
Cdd:cd19512    15 TKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-------VAPMGREGVTAIHKVFDWANTSRRGLLLFV 87


                  ....
gi 1727596665 274 DGAD 277
Cdd:cd19512    88 DEAD 91
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
204-224 2.00e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 38.74  E-value: 2.00e-03
                          10        20
                  ....*....|....*....|.
gi 1727596665 204 VLFTGPPGTGKTTIAKALGAK 224
Cdd:COG0645     2 ILVCGLPGSGKSTLARALAER 22
CysC COG0529
Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; ...
 195-233 2.28e-03

Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; Adenylylsulfate kinase or related kinase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 440295 [Multi-domain]  Cd Length: 189  Bit Score: 38.92  E-value: 2.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1727596665 195 RYGQSGMrkVL-FTGPPGTGKTTIAKALGAKYQDKYVFVY 233
Cdd:COG0529    11 LKGQKGF--VVwFTGLSGSGKSTLANALERRLFERGRHVY 48
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 202-224 3.18e-03

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 38.58  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|...
gi 1727596665 202 RKVLFTGPPGTGKTTIAKALGAK 224
Cdd:cd19508    53 RLVLLHGPPGTGKTSLCKALAQK 75
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 204-221 3.59e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 38.67  E-value: 3.59e-03
                          10
                  ....*....|....*...
gi 1727596665 204 VLFTGPPGTGKTTIAKAL 221
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKRL 42
AAA_18 pfam13238
AAA domain;
204-275 4.38e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 37.02  E-value: 4.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1727596665 204 VLFTGPPGTGKTTIAKAL------GAKYQD---KYVFVYADDYFKDVCYAAAQKKIPVIIiaEEVDELYRADAGTLSFLD 274
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELskrlgfGDNVRDlalENGLVLGDDPETRESKRLDEDKLDRLL--DLLEENAALEEGGNLIID 78


                  .
gi 1727596665 275 G 275
Cdd:pfam13238  79 G 79
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 204-221 4.38e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 38.91  E-value: 4.38e-03
                          10
                  ....*....|....*...
gi 1727596665 204 VLFTGPPGTGKTTIAKAL 221
Cdd:PRK13342   39 MILWGPPGTGKTTLARII 56
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 204-237 4.81e-03

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 37.23  E-value: 4.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1727596665 204 VLFTGPPGTGKTTIAKALGAKYQdkYVFVYADDY 237
Cdd:cd02021     2 IVVMGVSGSGKSTVGKALAERLG--APFIDGDDL 33
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 199-221 5.19e-03

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 37.78  E-value: 5.19e-03
                          10        20
                  ....*....|....*....|...
gi 1727596665 199 SGMrKVLFTGPPGTGKTTIAKAL 221
Cdd:COG4088     3 SPM-LLILTGPPGSGKTTFAKAL 24
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
201-230 5.41e-03

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 37.49  E-value: 5.41e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1727596665 201 MRKVLfTGPPGTGKTTIAKALGAKYQDKYV 230
Cdd:COG1936     1 MRIAI-TGTPGTGKTTVAKLLAERLGLEVI 29
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
204-224 6.80e-03

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 38.19  E-value: 6.80e-03
                          10        20
                  ....*....|....*....|....*
gi 1727596665 204 VLFTGPPGTGKTT----IAKALGAK 224
Cdd:PRK00080   54 VLLYGPPGLGKTTlaniIANEMGVN 78
PLN03025 PLN03025
replication factor C subunit; Provisional
 201-262 7.10e-03

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 38.17  E-value: 7.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1727596665 201 MRKVLFTGPPGTGKTTIAKA-----LGAKYQDKYVFVYA-DDYFKDVCYAA----AQKKIPV------IIIAEEVDEL 262
Cdd:PLN03025   34 MPNLILSGPPGTGKTTSILAlahelLGPNYKEAVLELNAsDDRGIDVVRNKikmfAQKKVTLppgrhkIVILDEADSM 111
COG3911 COG3911
Predicted ATPase [General function prediction only];
201-224 7.19e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443117  Cd Length: 180  Bit Score: 37.49  E-value: 7.19e-03
                          10        20
                  ....*....|....*....|....
gi 1727596665 201 MRKVLFTGPPGTGKTTIAKALGAK 224
Cdd:COG3911     3 TRRIVITGGPGSGKTTLLNALARR 26
Lon COG0466
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
 205-225 7.62e-03

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440234 [Multi-domain]  Cd Length: 785  Bit Score: 38.46  E-value: 7.62e-03
                          10        20
                  ....*....|....*....|....*
gi 1727596665 205 LFTGPPGTGKTT----IAKALGAKY 225
Cdd:COG0466   356 CLVGPPGVGKTSlgksIARALGRKF 380
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 205-226 7.69e-03

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 37.15  E-value: 7.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 1727596665 205 LFTGPPGTGKTT----IAKALGAKYQ 226
Cdd:cd19500    41 CLVGPPGVGKTSlgksIARALGRKFV 66
PRK04195 PRK04195
replication factor C large subunit; Provisional
 202-268 7.74e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 38.36  E-value: 7.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1727596665 202 RKVLFTGPPGTGKTTIAKALGAKYQDKYVFVYADDY-----FKDVCYAAAQKKI-----PVIIIAEEVDELY-RADAG 268
Cdd:PRK04195   40 KALLLYGPPGVGKTSLAHALANDYGWEVIELNASDQrtadvIERVAGEAATSGSlfgarRKLILLDEVDGIHgNEDRG 117
PRK04182 PRK04182
cytidylate kinase; Provisional
 208-240 8.88e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 37.09  E-value: 8.88e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1727596665 208 GPPGTGKTTIAKALGAKYqdKYVFVYADDYFKD 240
Cdd:PRK04182    7 GPPGSGKTTVARLLAEKL--GLKHVSAGEIFRE 37
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 204-221 9.02e-03

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 38.11  E-value: 9.02e-03
                          10
                  ....*....|....*...
gi 1727596665 204 VLFTGPPGTGKTTIAKAL 221
Cdd:COG2256    52 MILWGPPGTGKTTLARLI 69
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 202-262 9.02e-03

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 36.75  E-value: 9.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1727596665 202 RKVLFTGPPGTGKTTIAKALGAKYQDKYVFV--------YADDYFKDV--CYAAAQKKIPVIIIAEEVDEL 262
Cdd:cd19524    34 RGLLLFGPPGNGKTMLAKAVAAESNATFFNIsaasltskYVGEGEKLVraLFAVARELQPSIIFIDEVDSL 104
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 204-221 9.45e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 38.10  E-value: 9.45e-03
                          10
                  ....*....|....*...
gi 1727596665 204 VLFTGPPGTGKTTIAKAL 221
Cdd:COG0606   214 LLMIGPPGSGKTMLARRL 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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