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Conserved domains on  [gi|1750994946|gb|QET56406|]
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HNH endonuclease [Citrobacter portucalensis]

Protein Classification

HNH endonuclease( domain architecture ID 11465816)

HNH endonuclease may catalyze the hydrolysis of DNA, similar to Vibrio campbellii HNH endonuclease VcaM4I

EC:  3.1.-.-
Gene Ontology:  GO:0004519|GO:0003677

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
COG3440 COG3440
Predicted restriction endonuclease [Defense mechanisms];
135-289 1.33e-55

Predicted restriction endonuclease [Defense mechanisms];


:

Pssm-ID: 442665  Cd Length: 150  Bit Score: 176.34  E-value: 1.33e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750994946 135 AQQILEAHFTESIQEEIADElGFDILQIRKQRDPLFRQQVLRAYNYECAICGFnmrhdSTSVALEAAHIK-WKQHGGPCE 213
Cdd:COG3440     1 AEQLLDALFLEEEPDELERT-ERERLVKRRVRQGAFRKAVLEAYDGRCAVTGL-----DIPPLLEAAHIKpWSDHGGRDD 74
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1750994946 214 ISNGLALCAIHHKAFDKGSIGLDESMRVQVSPAVNGSGMVGRLFWDFDGKSIALPMMRENYPKEGFVEWHRKEVFR 289
Cdd:COG3440    75 VSNGLLLCPNHHALFDRGLITIDDDYRILVSPRLKEESDLIRELKELHGRKLRLPEHERFRPDPEYLAWHRENVFK 150
 
Name Accession Description Interval E-value
COG3440 COG3440
Predicted restriction endonuclease [Defense mechanisms];
135-289 1.33e-55

Predicted restriction endonuclease [Defense mechanisms];


Pssm-ID: 442665  Cd Length: 150  Bit Score: 176.34  E-value: 1.33e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750994946 135 AQQILEAHFTESIQEEIADElGFDILQIRKQRDPLFRQQVLRAYNYECAICGFnmrhdSTSVALEAAHIK-WKQHGGPCE 213
Cdd:COG3440     1 AEQLLDALFLEEEPDELERT-ERERLVKRRVRQGAFRKAVLEAYDGRCAVTGL-----DIPPLLEAAHIKpWSDHGGRDD 74
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1750994946 214 ISNGLALCAIHHKAFDKGSIGLDESMRVQVSPAVNGSGMVGRLFWDFDGKSIALPMMRENYPKEGFVEWHRKEVFR 289
Cdd:COG3440    75 VSNGLLLCPNHHALFDRGLITIDDDYRILVSPRLKEESDLIRELKELHGRKLRLPEHERFRPDPEYLAWHRENVFK 150
HNH_2 pfam13391
HNH endonuclease;
182-236 1.03e-08

HNH endonuclease;


Pssm-ID: 433168  Cd Length: 66  Bit Score: 50.86  E-value: 1.03e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1750994946 182 CAICGFNMRHdstsvALEAAHIKWKQH-------------GGPCEI---SNGLALCAIHHKAFDKGSIGLD 236
Cdd:pfam13391   1 CVITGIDAPG-----LLEAAHIFPWSLslgdrrfsairlgEGPSGIdspRNGLLLRPDLHRLFDRGLFAID 66
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
173-226 4.47e-03

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 34.75  E-value: 4.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1750994946 173 QVLRAYNYECAICGFnmrhDSTSVALEAAHIKWKQHGGPCEISNGLALCAIHHK 226
Cdd:cd00085     5 LVLLARDGLCPYCGK----PGGTEGLEVDHIIPLSDGGNNDLDNLVLLCRKCHR 54
HNHc smart00507
HNH nucleases;
173-225 9.30e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 33.59  E-value: 9.30e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1750994946  173 QVLRAYNYECAICGfnmrhDSTSVALEAAHIKWKQHGGPCEISNGLALCAIHH 225
Cdd:smart00507   4 RLLLHRDGVCAYCG-----KPASEGLEVDHIIPLSDGGNDDLDNLVLLCPKCH 51
 
Name Accession Description Interval E-value
COG3440 COG3440
Predicted restriction endonuclease [Defense mechanisms];
135-289 1.33e-55

Predicted restriction endonuclease [Defense mechanisms];


Pssm-ID: 442665  Cd Length: 150  Bit Score: 176.34  E-value: 1.33e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750994946 135 AQQILEAHFTESIQEEIADElGFDILQIRKQRDPLFRQQVLRAYNYECAICGFnmrhdSTSVALEAAHIK-WKQHGGPCE 213
Cdd:COG3440     1 AEQLLDALFLEEEPDELERT-ERERLVKRRVRQGAFRKAVLEAYDGRCAVTGL-----DIPPLLEAAHIKpWSDHGGRDD 74
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1750994946 214 ISNGLALCAIHHKAFDKGSIGLDESMRVQVSPAVNGSGMVGRLFWDFDGKSIALPMMRENYPKEGFVEWHRKEVFR 289
Cdd:COG3440    75 VSNGLLLCPNHHALFDRGLITIDDDYRILVSPRLKEESDLIRELKELHGRKLRLPEHERFRPDPEYLAWHRENVFK 150
HNH_2 pfam13391
HNH endonuclease;
182-236 1.03e-08

HNH endonuclease;


Pssm-ID: 433168  Cd Length: 66  Bit Score: 50.86  E-value: 1.03e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1750994946 182 CAICGFNMRHdstsvALEAAHIKWKQH-------------GGPCEI---SNGLALCAIHHKAFDKGSIGLD 236
Cdd:pfam13391   1 CVITGIDAPG-----LLEAAHIFPWSLslgdrrfsairlgEGPSGIdspRNGLLLRPDLHRLFDRGLFAID 66
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
163-227 2.22e-06

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 44.20  E-value: 2.22e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1750994946 163 RKQRDPLFRQQVLRAYNYECAICGfnmRHDSTSvALEAAHIKWKQHGGPCEISNGLALCAIHHKA 227
Cdd:COG1403     3 PGREWPALRRAVLKRDNGRCQYCG---RPFSGD-ALEVDHIIPRSRGGTDTWENLVLLCRRCNRR 63
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
159-244 6.53e-06

Predicted restriction endonuclease, HNH family [Defense mechanisms];


Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 44.22  E-value: 6.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750994946 159 ILQIRKQRDPLFRQQVLRAYNYECAICGFNMRHDSTSVA---LEAAHIKW--KQH-GGPCEISNGLALCAIHHKAFDKGS 232
Cdd:COG3183    16 VTHKRYERNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGegyIEVHHLIPlsEIGeGGVDPIEDLVPLCPNCHRMLHRGR 95
                          90
                  ....*....|...
gi 1750994946 233 IGLD-ESMRVQVS 244
Cdd:COG3183    96 PPLSiEELKKLLK 108
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
173-226 4.47e-03

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 34.75  E-value: 4.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1750994946 173 QVLRAYNYECAICGFnmrhDSTSVALEAAHIKWKQHGGPCEISNGLALCAIHHK 226
Cdd:cd00085     5 LVLLARDGLCPYCGK----PGGTEGLEVDHIIPLSDGGNNDLDNLVLLCRKCHR 54
HNHc smart00507
HNH nucleases;
173-225 9.30e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 33.59  E-value: 9.30e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1750994946  173 QVLRAYNYECAICGfnmrhDSTSVALEAAHIKWKQHGGPCEISNGLALCAIHH 225
Cdd:smart00507   4 RLLLHRDGVCAYCG-----KPASEGLEVDHIIPLSDGGNDDLDNLVLLCPKCH 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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