|
Name |
Accession |
Description |
Interval |
E-value |
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
274-803 |
1.27e-167 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 494.15 E-value: 1.27e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 274 GLLKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAMKDDEDGGEA 353
Cdd:TIGR01695 1 SLLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEARRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 354 FANRLLTLVMVALGALTVITVFAAPLLIRLLSNPVASDPAAneVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMW 433
Cdd:TIGR01695 81 FANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGFADETRS--LAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPSF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 434 TPVLNNIVIIVTLGLFIWVYGTAETSGMKVTSIppegerllgigvllGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGK 513
Cdd:TIGR01695 159 SPILFNIGVILSLLFFDWNYGQYSLALAIGVLI--------------GGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKR 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 514 AITLAKWTVLFVLANQAGAMIVIqlstaaGKASPVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGA 593
Cdd:TIGR01695 225 FLKLFLPTTLGSSASQITLLINT------ALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNE 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 594 VRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGSS--GTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRT 671
Cdd:TIGR01695 299 LRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFERGafSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRT 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 672 PFYNTvivaVVNAAASGLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGDLDGaRVLRTYARLCIASvpaAL 751
Cdd:TIGR01695 379 PFINS----VISVVLNALLSLLLIFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPF-GVLKVLAKLVIAS---AI 450
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1759038063 752 IGGAACYAISRSLGQGVVGSLAALLAGGVLLFGVFFVAARRMRIEEVNSLVG 803
Cdd:TIGR01695 451 IGGVLYLIVSVSLGGVLVKNLLGLLAIGLIGLLVYFLGLALLKIEELNLLLR 502
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
300-778 |
1.12e-135 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 410.14 E-value: 1.12e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 300 IVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAMKDDEDGGEAFANRLLTLVMVALGALTVITVFAAPL 379
Cdd:pfam03023 1 IAAYFGAGLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKAQDKEEAAEFVRKVSTLLILVLLLVTLIGILAAPW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 380 LIRLLSNPvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIVIIVTLGLFIWVYGTAETS 459
Cdd:pfam03023 81 LIRLLAPG--FDPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNAIYA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 460 GMKVTSIppegerllgigvllGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGKAITLAKWTVLFVLANQAGAMIVIQLs 539
Cdd:pfam03023 159 LAIGVLI--------------GGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFL- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 540 taagkASPVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVAL 619
Cdd:pfam03023 224 -----ASFLAPGSVSYLYYADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 620 GIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTvivaVVNAAASGLCYLLLPSR 697
Cdd:pfam03023 299 SIPIVSLLFerGNFSPEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKIS----LISAVLNILLSLLLLPP 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 698 WAVVGMAASYGLAYVIGVGIAWRRLRKRLGGdlDGARVLRTYARLciASVPAALIGGAACYAISRSLGQGVVGSLAALLA 777
Cdd:pfam03023 375 LGVAGLALATSLSSLIGLVFLYYILRKRLGG--FDLRGIKTFLAS--LVVPTALMAGVILLLSSLTQGPWVVGSLLLILV 450
|
.
gi 1759038063 778 G 778
Cdd:pfam03023 451 G 451
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
276-796 |
2.88e-131 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 400.68 E-value: 2.88e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 276 LKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAM-KDDEDGGEAF 354
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALeKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 355 ANRLLTLVMVALGALTVITVFAAPLLIRLLSNpvASDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWT 434
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAP--GFDPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 435 PVLNNIVIIVTLGLFIWVYGTAETS---GMKVTSIppegerllgigvllgliVQSLAMIPYLRETGFRLRLRFDWRGHGL 511
Cdd:COG0728 159 PVLLNLVIIAGLLLLAPLFGPGIYAlawGVLLGGV-----------------LQLLIQLPALRRLGLRLRPRFDLRDPGV 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 512 GKAITLAKWTVLFVLANQAGAMIVIQLSTAAGKASPvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDG 591
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSV------SALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 592 GAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDT 669
Cdd:COG0728 296 EEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFerGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDT 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 670 RTPFYNTVIVAVVNAaasgLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGdLDGARVLRTYARLCIASVPA 749
Cdd:COG0728 376 RTPVRIAVIAVVVNI----VLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLGG-LPLRGILRTLLKLLLASLVM 450
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1759038063 750 ALIGGAACYAISRSLGQGVVGSLAALLAGGVLLFGVFFVAARRMRIE 796
Cdd:COG0728 451 GAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFALLLLLGVR 497
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
283-725 |
4.43e-114 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 352.91 E-value: 4.43e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 283 AAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAM-KDDEDGGEAFANRLLTL 361
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLeKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 362 VMVALGALTVITVFAAPLLIRLLSNPvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIV 441
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPG--FSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 442 IIVTLGLFIWVygtaetsgmkvtsiPPEGERLLGIGVLLGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGKAITLAKWT 521
Cdd:cd13123 159 IIAGLLLLAPL--------------FDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 522 VLFVLANQAGAMIVIQLSTAAGKASPvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGAVRDDISQG 601
Cdd:cd13123 225 LLGVSVSQINLLVDTILASFLPEGSI------SALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 602 LRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTviv 679
Cdd:cd13123 299 LRLVLFLLLPAAVGLIVLAEPIVRLLFerGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIA--- 375
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1759038063 680 aVVNAAASGLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKR 725
Cdd:cd13123 376 -VIAVAVNILLNLLLIKPLGHVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| DUF1373 |
pfam07117 |
Protein of unknown function (DUF1373); This family consists of several hypothetical proteins ... |
203-285 |
1.08e-03 |
|
Protein of unknown function (DUF1373); This family consists of several hypothetical proteins which seem to be specific to Oryzias latipes (Japanese ricefish). Members of this family are typically around 200 residues in length. The function of this family is unknown.
Pssm-ID: 462093 [Multi-domain] Cd Length: 212 Bit Score: 41.32 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 203 PDPYGNAQTHGQYG---GSAQYGGSAATPGQHAaPAPGQYAVAPTPEAAEAPLQEPEPEPAASQAAPKKGGRAGGLLKSS 279
Cdd:pfam07117 33 PLPPGQEPEPPRPEeeeGQGGGGGTFPFPGSPE-PEPGGGGSGPMPMSASAPEPEPAKAKPQRPAPAQGHGHGGGGDSDS 111
|
....*.
gi 1759038063 280 AVMAAG 285
Cdd:pfam07117 112 SGSGSG 117
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
212-266 |
1.99e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.90 E-value: 1.99e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1759038063 212 HGQYGGSAQYGGSAATPGQHAAPAPGQYAVAPTPEAAEAPLQEPEPEPAASQAAP 266
Cdd:PRK07764 384 RLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPA 438
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
274-803 |
1.27e-167 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 494.15 E-value: 1.27e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 274 GLLKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAMKDDEDGGEA 353
Cdd:TIGR01695 1 SLLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEARRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 354 FANRLLTLVMVALGALTVITVFAAPLLIRLLSNPVASDPAAneVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMW 433
Cdd:TIGR01695 81 FANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGFADETRS--LAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPSF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 434 TPVLNNIVIIVTLGLFIWVYGTAETSGMKVTSIppegerllgigvllGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGK 513
Cdd:TIGR01695 159 SPILFNIGVILSLLFFDWNYGQYSLALAIGVLI--------------GGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKR 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 514 AITLAKWTVLFVLANQAGAMIVIqlstaaGKASPVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGA 593
Cdd:TIGR01695 225 FLKLFLPTTLGSSASQITLLINT------ALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNE 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 594 VRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGSS--GTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRT 671
Cdd:TIGR01695 299 LRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFERGafSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRT 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 672 PFYNTvivaVVNAAASGLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGDLDGaRVLRTYARLCIASvpaAL 751
Cdd:TIGR01695 379 PFINS----VISVVLNALLSLLLIFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPF-GVLKVLAKLVIAS---AI 450
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1759038063 752 IGGAACYAISRSLGQGVVGSLAALLAGGVLLFGVFFVAARRMRIEEVNSLVG 803
Cdd:TIGR01695 451 IGGVLYLIVSVSLGGVLVKNLLGLLAIGLIGLLVYFLGLALLKIEELNLLLR 502
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
300-778 |
1.12e-135 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 410.14 E-value: 1.12e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 300 IVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAMKDDEDGGEAFANRLLTLVMVALGALTVITVFAAPL 379
Cdd:pfam03023 1 IAAYFGAGLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKAQDKEEAAEFVRKVSTLLILVLLLVTLIGILAAPW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 380 LIRLLSNPvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIVIIVTLGLFIWVYGTAETS 459
Cdd:pfam03023 81 LIRLLAPG--FDPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNAIYA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 460 GMKVTSIppegerllgigvllGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGKAITLAKWTVLFVLANQAGAMIVIQLs 539
Cdd:pfam03023 159 LAIGVLI--------------GGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFL- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 540 taagkASPVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVAL 619
Cdd:pfam03023 224 -----ASFLAPGSVSYLYYADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 620 GIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTvivaVVNAAASGLCYLLLPSR 697
Cdd:pfam03023 299 SIPIVSLLFerGNFSPEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKIS----LISAVLNILLSLLLLPP 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 698 WAVVGMAASYGLAYVIGVGIAWRRLRKRLGGdlDGARVLRTYARLciASVPAALIGGAACYAISRSLGQGVVGSLAALLA 777
Cdd:pfam03023 375 LGVAGLALATSLSSLIGLVFLYYILRKRLGG--FDLRGIKTFLAS--LVVPTALMAGVILLLSSLTQGPWVVGSLLLILV 450
|
.
gi 1759038063 778 G 778
Cdd:pfam03023 451 G 451
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
276-796 |
2.88e-131 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 400.68 E-value: 2.88e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 276 LKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAM-KDDEDGGEAF 354
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALeKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 355 ANRLLTLVMVALGALTVITVFAAPLLIRLLSNpvASDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWT 434
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAP--GFDPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 435 PVLNNIVIIVTLGLFIWVYGTAETS---GMKVTSIppegerllgigvllgliVQSLAMIPYLRETGFRLRLRFDWRGHGL 511
Cdd:COG0728 159 PVLLNLVIIAGLLLLAPLFGPGIYAlawGVLLGGV-----------------LQLLIQLPALRRLGLRLRPRFDLRDPGV 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 512 GKAITLAKWTVLFVLANQAGAMIVIQLSTAAGKASPvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDG 591
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSV------SALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 592 GAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDT 669
Cdd:COG0728 296 EEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFerGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDT 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 670 RTPFYNTVIVAVVNAaasgLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGdLDGARVLRTYARLCIASVPA 749
Cdd:COG0728 376 RTPVRIAVIAVVVNI----VLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLGG-LPLRGILRTLLKLLLASLVM 450
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1759038063 750 ALIGGAACYAISRSLGQGVVGSLAALLAGGVLLFGVFFVAARRMRIE 796
Cdd:COG0728 451 GAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFALLLLLGVR 497
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
283-725 |
4.43e-114 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 352.91 E-value: 4.43e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 283 AAGTMVSRLTGFVRSALIVSALGVGLLGDTFQVAYQLPTMIYILTVGGGLNSVFVPQLVRAM-KDDEDGGEAFANRLLTL 361
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLeKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 362 VMVALGALTVITVFAAPLLIRLLSNPvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIV 441
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPG--FSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 442 IIVTLGLFIWVygtaetsgmkvtsiPPEGERLLGIGVLLGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGKAITLAKWT 521
Cdd:cd13123 159 IIAGLLLLAPL--------------FDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 522 VLFVLANQAGAMIVIQLSTAAGKASPvdgtgfAAYANAQLIWGLPQAIITVSLMAALLPRISRSASEEDGGAVRDDISQG 601
Cdd:cd13123 225 LLGVSVSQINLLVDTILASFLPEGSI------SALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 602 LRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTviv 679
Cdd:cd13123 299 LRLVLFLLLPAAVGLIVLAEPIVRLLFerGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIA--- 375
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1759038063 680 aVVNAAASGLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKR 725
Cdd:cd13123 376 -VIAVAVNILLNLLLIKPLGHVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
275-719 |
9.61e-19 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 88.85 E-value: 9.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 275 LLKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGdTFQVAYQLPTMIYILtVGGGLNSVFVPQLVRAmkdDEDGGEAF 354
Cdd:COG2244 4 LLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYG-LFALALSIVALLSVL-ADLGLSTALVRFIAEY---REEELRRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 355 ANRLLTLVMVALGALTVITVFAAPLLIRLLSNPVAsdpaanevgITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWT 434
Cdd:COG2244 79 LSTALLLRLLLSLLLALLLLLLAPFIAALLGEPEL---------ALLLLLLALALLLSALSAVLLALLRGLERFKLLALI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 435 PVLNNIVIIVTLGLFIWVygtaetsGMKVTSIPpegerllgigvllglivqslamipylretgfrlrLRFdwrghglGKA 514
Cdd:COG2244 150 NILSSLLSLLLALLLALL-------GLGLWGLV----------------------------------LKY-------SLP 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 515 ITLAkwTVLFVLANQAGAMIVIQLSTAAGkaspvdgtgFAAYANAQLIWGLPQAIITvSLMAALLPRISRSASEEDGGAV 594
Cdd:COG2244 182 LLLS--GLLGLLLTNLDRLLLGALLGPAA---------VGIYSAAYRLASLLLLLIT-ALSQVLFPRLSRLLAEGDREEL 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 595 RDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGssgtSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFY 674
Cdd:COG2244 250 RRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFG----PEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLI 325
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1759038063 675 NTVIVAVVNAaasGLCYLLLPsRWAVVGMAASYGLAYVIGVGIAW 719
Cdd:COG2244 326 ISLIGAVLNL---VLNLLLIP-RYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
280-727 |
5.11e-16 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 81.36 E-value: 5.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 280 AVMAAGTMVSRLTGFV-RSAL--IVSALGVGLlgdtFQVAYQLPTMIYILTVGGglNSVFVPQLV---RAMKDDEDGGEA 353
Cdd:cd13124 1 LILTIAGLISKILGAIyRIPLqnIIGDEGMGL----YQMAYPIYGIFLTLATAG--IPVAISKLVaeyNALGDYKGARRI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 354 FanRLLTLVMVALGAL-TVITVFAAPLLIRLLSNpvasDPAAnevgITFVRYFLPSIFFMGLHVVMgqvlnaRGRF-GAM 431
Cdd:cd13124 75 F--RVSLILLLILGLVfFLLLFFGAPFLAQLLLG----DPRL----APVIRALAPAILIVPLLSVL------RGYFqGLQ 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 432 MWTP-----VLNNIV-IIVTLGLFIWVY---------GTAETSGMKVTSIppegerllgigvllglivQSLAMIPYLret 496
Cdd:cd13124 139 NMTPtavsqVIEQIVrVIVILVLAYLLLpvggglyyaAAGATFGAVIGAL------------------AGLLVLLYY--- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 497 gFRLRLRFDWRGHGLGKAITLAKWTVLFVLANQAG----------------AMIVIQLSTAAGKASPVDGTGFAAYA-NA 559
Cdd:cd13124 198 -YRKKRRELKRLLRKSPRSKISTKEILKELLSYAIpitlsslilpllqlidSFTVPRRLQAAGLSESEATALYGILTgRA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 560 QLIWGLPqAIITVSLMAALLPRISRSASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGSSgtseatNM 639
Cdd:cd13124 277 QPLVQLP-TVIATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDS------EG 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 640 GYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIvavvnaaasGLC------YLLLPsRWAVVGMAASYGLAYVI 713
Cdd:cd13124 350 GLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLI---------GLLvkivlnYVLIP-IFGIYGAAIATVIGFLV 419
|
490
....*....|....
gi 1759038063 714 GVGIAWRRLRKRLG 727
Cdd:cd13124 420 AALLNLRALKKLLG 433
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
275-723 |
7.39e-10 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 61.79 E-value: 7.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 275 LLKSSAVMAAGTMVSRLTGFVRSALIVSALGVGLLGdtfQVAYQLPTMIYILTV-GGGLNSVFVPQLVRAMKDDEDggEA 353
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFG---ILSLALAFVGLFSIFaDLGLPTALVREIARYRKEKIR--EI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 354 FANrlLTLVMVALGALTVITVFAAPLLIRLLSNPVasdpaanevgITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMW 433
Cdd:cd13128 76 IST--SLVLKLILGILALLLLFLFAFLIAFYDPEL----------VLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 434 TPVLNNIVIIVTLGLFI------WVYGTAETSGMKVTSIppegerllgigvllglivqsLAMIPYLRETGFRLRLRFD-- 505
Cdd:cd13128 144 ARIIESVLSLILALILVllggglIGFALAYLIASVLSAI--------------------LLLYIYRKKILLPKFFSFDlk 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 506 -WRGHgLGKAITLAKWTVLFVLANQagaMIVIQLSTAAGKASpvdgTGF--AAYANAQLIWGLPQAIITVslmaaLLPRI 582
Cdd:cd13128 204 lAKEL-LRFSIPLALSGIFSLIYTR---IDTIMLGYFLGDAA----VGIynAAYRIAELLLFIPSAISTA-----LFPRI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 583 SRsASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGssgtSEATNMGYMLMAFGLGLIPYSVQYVVLRA 662
Cdd:cd13128 271 SE-LYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFG----EEYLPAALVLQILAWGFLFIFLNGIFGSI 345
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1759038063 663 FYAYEDTRTPFYNTVIVAVVNAaasGLCYLLLPsRWAVVGMAASYGLAYVIGVGIAWRRLR 723
Cdd:cd13128 346 LQAIGKQKLTLKILLIGALLNV---ILNLLLIP-KYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
272-721 |
1.62e-09 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 60.93 E-value: 1.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 272 AGGLLKSSAVMAAGTMVSRLtgfvrSALIVSALGVGLlgdtfqvayqlPTMIYILTVGGGLN---SVFVPQLVRAmKDDE 348
Cdd:COG0534 19 LGNLLQSLYGLVDTIFVGRL-----GTAALAAVGLAF-----------PIFFLLIALGIGLGvggTALVAQALGA-GDRE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 349 DGGEAFANrLLTLVMVALGALTVITVFAAPLLIRLLSnpvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRF 428
Cdd:COG0534 82 EARRVLGQ-ALLLALLLGLLLTLLGLLFAPPLLRLLG----ADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 429 GAMMWTPVLNNIVIIVTLGLFIWVYgtaetsGMKV------TSIppegerllgigvllGLIVQSLAMIPYL--RETGFRL 500
Cdd:COG0534 157 KTPMIIMLIGNVLNIVLDPLLIFGG------GLGVagaalaTVI--------------SQAVSALLLLYYLfrKRSLLRL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 501 RLR-FDWRGHGLGKAITLAKWTVLFVLANQAGAMIVIQLSTAAGKaspvdgTGFAAYANAQLIWGLPQAIItVSLMAALL 579
Cdd:COG0534 217 RLRdLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGT------AAVAAYGIALRIESLAFMPA-LGLGQAAQ 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 580 PRISRSASEEDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMfgsSGTSEATNMG-YMLMAFGLGLIPYSVQYV 658
Cdd:COG0534 290 PLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLF---TDDPEVIALAaTYLRIAALFQPFDGLQFV 366
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1759038063 659 VLRAFYAYEDTRTPFYNTVIVAVVNAAasGLCYLLLPSRWAVVGMAASYGLAYVIGVGIAWRR 721
Cdd:COG0534 367 LSGALRGAGDTRFPMIISLLRLWLVRL--PLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
282-718 |
5.69e-08 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 55.79 E-value: 5.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 282 MAAGTMVSRLTGFVRSALIVSALGVGLLGDTFqVAYQLPTMIYILTVGGGLNSVFVPQLVRAmkDDEDGGEAFANRLLTL 361
Cdd:cd12082 4 LLLSMLLQTLYNLVDTFFLGRLLGDALAAVGL-AFPLIALLIALGVGLSVGTSALISQAIGA--GDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 362 VMVALGALTVITVFAAPLLIRLLSnpvaSDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIV 441
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLG----AEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 442 IIVtlGLFIWVYGTAeTSGMKVTSIPpegerLLGIGVLLGLIVQSLAMIPYLRETGFRLRLRFDWRGHGLGKAITLAKWT 521
Cdd:cd12082 157 NIL--LDPLLIFGLG-PPELGIAGAA-----LATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 522 VLFVLANQAGAMIVIQLSTAAGKASPVdgtgfAAYANAQLIWGLPQAIItVSLMAALLPRISRSASeedggavRDDISQG 601
Cdd:cd12082 229 AIQNSLLSLGLLIIVAIVAAFGGAAAL-----AAYTVAFRIASLAFMPA-LGLAQAALPVVGQNLG-------AGNFDRA 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 602 LRTTAVAIVpvsFGFVALGIPMCTLMFG--------SSGTSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPF 673
Cdd:cd12082 296 RRITWVALL---IGLLIGAVLGLLILLFpepilslfTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSL 372
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1759038063 674 YNTVIVAVVNAAasGLCYLLLPSRWAVVGMAASYGLAYVIGVGIA 718
Cdd:cd12082 373 IVSLLSYWVVRL--PLAYVLAYLGLGLYGIWLALVISLILAALVL 415
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
362-730 |
8.60e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 55.18 E-value: 8.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 362 VMVALGA-LTVITVFAAPLLIRLLSNPVASDPaanevgitfVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNI 440
Cdd:cd13127 77 LNLLLGLlLYLLLFLLAPLIAAFYNEPELIPL---------LRVLSLSFLLSGLGSVPRALLQRELRFKKLAIIELISTL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 441 V-IIVTLGLFIWvygtaetsGMKVTSIppegerllgigVLLGLIVQSLAMIPYLRETGFRLRLRFDWRGH----GLGKAI 515
Cdd:cd13127 148 VsGVVAIVLALL--------GFGVWAL-----------VAQQLVGALVSTVLLWILSRWRPRLSFSLASLkellSFGSKL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 516 TLAkwTVLFVLANQAGAMIViqlstaaGKASPVDGTGFaaYANAQLIWGLPQAIITVSLMAALLPRISRSASeeDGGAVR 595
Cdd:cd13127 209 LGS--NLLNYFSRNLDNLII-------GKFLGAAALGY--YSRAYRLALLPVQNITGPITRVLFPALSRLQD--DPERLR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 596 DDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGssgtSEATNMGYMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYN 675
Cdd:cd13127 276 RAYLKALRLLALITFPLMVGLALLAEPLVLLLLG----EKWLPAVPILQILALAGLFQPLSSLNGSLLLALGRTDLLLKL 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1759038063 676 TVIVAVVNAAAsglcyLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGGDL 730
Cdd:cd13127 352 GLIKAVLTVLA-----LLIGIPYGIIGVAIAYVIASLLSFPLNLYLAGRLIGISL 401
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
287-456 |
6.53e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 52.49 E-value: 6.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 287 MVSRLTGFVRS----ALIVSALGVGLLGdTFQVAYQLPTMIyILTVGGGLNSVFVPQLVRAMKDDEDGGEAFaNRLLTLV 362
Cdd:cd13127 209 LGSNLLNYFSRnldnLIIGKFLGAAALG-YYSRAYRLALLP-VQNITGPITRVLFPALSRLQDDPERLRRAY-LKALRLL 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 363 MVALGALTVITVFAAPLLIRLL--SNPVASdpaanevgITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNI 440
Cdd:cd13127 286 ALITFPLMVGLALLAEPLVLLLlgEKWLPA--------VPILQILALAGLFQPLSSLNGSLLLALGRTDLLLKLGLIKAV 357
|
170
....*....|....*...
gi 1759038063 441 VIIVTL--GLFIWVYGTA 456
Cdd:cd13127 358 LTVLALliGIPYGIIGVA 375
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
283-426 |
9.30e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 49.05 E-value: 9.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 283 AAGTMVSRLTGFVRSALIVSALGVGLLGdTFQVAYQLPTMIYILTVGGGL-NSVFVPQLVRAmkDDEDGGEAFANRLLTL 361
Cdd:cd13137 235 AGLEQLLRSLGFLVLLAIVASYGTAALA-AYQIGLRIESLAFMPGFGFSMaASTLVGQNLGA--GDPDEARRYGKRALRL 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1759038063 362 VMVALGALTVITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARG 426
Cdd:cd13137 312 GVLFMGLLGLLLFIFAPPLASLFTP----DPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAG 372
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
642-795 |
1.01e-05 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 46.03 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 642 MLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPFYNTVIVAVVNAaasGLCYLLLPsRWAVVGMAASYGLAYVIGVGIAWRR 721
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKL---ILNLLLIP-LFGIVGAAIATVISLLVVALLNLYY 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1759038063 722 LRKRLGGDLdgarVLRTYARLCIASVPAALIGGAACYAISRSLGQGVvgslaALLAGGVLLFGVFFVAARRMRI 795
Cdd:pfam14667 77 LRRYLGLRL----LLRRLLKPLLAALVMGIVVYLLLLLLGLLLGLAL-----ALLLAVLVGALVYLLLLLLLKL 141
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
275-450 |
2.19e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 47.88 E-value: 2.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 275 LLKSSAVMAAGTMVSRLtgfvrSALIVSALGVGLlgdtfQVAYQLPTMIYILTVGGglnSVFVPQLVRAmKDDEDGGEAF 354
Cdd:cd13134 17 LLQMLLGTIDTFMLSRY-----SDNAVAAVGVAN-----QILFLLILIFSFISTGT---SILIAQYLGA-KDKKKARQIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 355 ANRLLTLVMVALgALTVITVFAAPLLIRLLSNPvasdPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWT 434
Cdd:cd13134 83 GVALLFNLLLGL-VFSLLLLFFGAELLRLMGLP----PELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYV 157
|
170
....*....|....*.
gi 1759038063 435 PVLNNIVIIVTLGLFI 450
Cdd:cd13134 158 SLIMNILNIVGNYLLI 173
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
287-725 |
1.04e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 45.58 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 287 MVSRLtgfvrSALIVSALGVGLlgdtfQVAYQLPTMIYILTVGGglnSVFVPQLVRAmKDDEDGGEAFANRLLTLVMVAL 366
Cdd:cd13137 27 MVGRL-----GAEAIAAVGLAT-----QVLWLLLVLNMALGTGT---VALVSQSYGA-GDYERARRALGQSLLLALLLSL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 367 gALTVITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIVIIVTL 446
Cdd:cd13137 93 -PLALLGLLFAEPLLRLLGA----DPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 447 GLFIwvYGTAETSGMKV------TSIppegerllgigvllgliVQSLAMIPYL-----RETGFRLRL-RFDWRGHGLGKA 514
Cdd:cd13137 168 YVLI--FGLWGFPGLGVagaalaTVI-----------------SRVVGALLLLflllrGRLPIKISFkGFRLDRKIIKKL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 515 ITLAKWTVLFVLANQAGAMIVIQLSTAAGKASpvdgtgFAAYANAQLIWGLPqAIITVSLMAALLPRISRSASEEDGGAV 594
Cdd:cd13137 229 LRIGLPAGLEQLLRSLGFLVLLAIVASYGTAA------LAAYQIGLRIESLA-FMPGFGFSMAASTLVGQNLGAGDPDEA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 595 RDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMfgsSGTSEATNMG-YMLMAFGLGLIPYSVQYVVLRAFYAYEDTRTPF 673
Cdd:cd13137 302 RRYGKRALRLGVLFMGLLGLLLFIFAPPLASLF---TPDPEVIELGvLYLRIVALSQPFLAISFVLSGALRGAGDTRPPL 378
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1759038063 674 YNTVIVAVVNAAasGLCYLL-LPSRWAVVGMAASYGLAYVIGVGIAWRRLRKR 725
Cdd:cd13137 379 IINLISMWLVRL--PLAYLLgFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKG 429
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
359-466 |
2.27e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 44.37 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 359 LTLVMVALGALTVITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNArgrFGAMMWTPVLN 438
Cdd:cd13138 308 IIISLIIGLIIILLVFFFAPQLLGLFTS----DPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRG---LGKTKFPMIIS 380
|
90 100
....*....|....*....|....*...
gi 1759038063 439 NIVIIVTLGLFIWVygTAETSGMKVTSI 466
Cdd:cd13138 381 ILRLWLVRIPLAYL--LSRLTGLGLFGI 406
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
282-455 |
4.02e-04 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 43.72 E-value: 4.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 282 MAAGTMVSRLTGFVRSalIVSALGVGLLGDTFQVAYQLPTMIYILT---VGGGLNSvfvpqlvrAMkdDEDGGEAFANRL 358
Cdd:cd13132 8 LAAPLVLTSLLQYSLS--VVSVVFVGHLGKLELAAASLASSFANVTgfsILLGLAS--------AL--DTLCGQAFGAKN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 359 LTLV-MVALGALTVITVFAAPL-LIRLLSNPVAS----DPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMM 432
Cdd:cd13132 76 YKLVgVYLQRALVILLLCCVPIsLLWLNTEPILLllgqDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLV 155
|
170 180
....*....|....*....|...
gi 1759038063 433 WTPVLNNIVIIVTLGLFIWVYGT 455
Cdd:cd13132 156 YISLVALLLNILLNYLLVFVLGL 178
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
277-619 |
4.77e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 43.30 E-value: 4.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 277 KSSAVMAAGTMVSRLTGFVRS---ALIVSALGVGLLGdTFQVAYQLPTMIyiltVGGGLNSVFVPQLVRAmKDDEDggea 353
Cdd:cd13125 1 KVSSLSGISTLIKILAGLIINkvvAVYLGPSGVALLG-QLQNFVTILQTI----AGGGINNGVVKYTAEY-KDDEE---- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 354 fanRLLTLVMVALGALTVITVFAAPLLIrLLSNPVASDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMW 433
Cdd:cd13125 71 ---KLARVWSTAFRITLILSILGGLLLL-LFSKPLSSLLFGDIDYSWVFILLGLALPLFALNNLLLAILNGLKEIKRYAL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 434 TPVLNNIVIIVTLGLFIWVYGTAETSGMKVTSippegerllgigvllglivQSLA---MIPYLRETGFRLRLRFDWRGHg 510
Cdd:cd13125 147 INIISSLIGLLVSVLLVYFYGLKGALLALVLN-------------------QSLIflvTLIYSRKQPWFKLKYLWGRLD- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 511 LGKAITLAKWTVLFVLANQAGAMIVIQLSTAAGKASPVDGTGFAayanaQLIWGLPQA---IITVSLMAALLPRISrSAS 587
Cdd:cd13125 207 KDIIKKLLKFSLMALVSALSLPLSQIIVRNILIRQLGWEAAGYW-----QAVWKISDVylgFITTALSTYYLPRLS-AIK 280
|
330 340 350
....*....|....*....|....*....|..
gi 1759038063 588 EEDggAVRDDISQGLRTTAVAIVPVSFGFVAL 619
Cdd:cd13125 281 DNK--ELKREVNKQLKVILPLVAIGALLIYLL 310
|
|
| DUF1373 |
pfam07117 |
Protein of unknown function (DUF1373); This family consists of several hypothetical proteins ... |
203-285 |
1.08e-03 |
|
Protein of unknown function (DUF1373); This family consists of several hypothetical proteins which seem to be specific to Oryzias latipes (Japanese ricefish). Members of this family are typically around 200 residues in length. The function of this family is unknown.
Pssm-ID: 462093 [Multi-domain] Cd Length: 212 Bit Score: 41.32 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 203 PDPYGNAQTHGQYG---GSAQYGGSAATPGQHAaPAPGQYAVAPTPEAAEAPLQEPEPEPAASQAAPKKGGRAGGLLKSS 279
Cdd:pfam07117 33 PLPPGQEPEPPRPEeeeGQGGGGGTFPFPGSPE-PEPGGGGSGPMPMSASAPEPEPAKAKPQRPAPAQGHGHGGGGDSDS 111
|
....*.
gi 1759038063 280 AVMAAG 285
Cdd:pfam07117 112 SGSGSG 117
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
361-427 |
1.61e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 41.79 E-value: 1.61e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1759038063 361 LVMVALGALTVITVFAAPLLIRLLSNpvasDPAANEVGITFVRYFLPSIFFMGLHVVMGQVLNARGR 427
Cdd:cd13142 322 LIFLILVIGGVLAFLFAEPIVRVFIN----DPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGH 384
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
212-266 |
1.99e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.90 E-value: 1.99e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1759038063 212 HGQYGGSAQYGGSAATPGQHAAPAPGQYAVAPTPEAAEAPLQEPEPEPAASQAAP 266
Cdd:PRK07764 384 RLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPA 438
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
209-266 |
2.55e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.51 E-value: 2.55e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1759038063 209 AQTHGQYGGSAQYGGSAATPGQHAAPAPGQYAVAPTPEAAEAPLQEPEPEPAASQAAP 266
Cdd:PRK07764 385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPP 442
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
326-454 |
6.35e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 39.80 E-value: 6.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 326 LTVGGGLNSVFVPQLvrAMKDDEDGGEAFANRLLTLVMVALGALTVITVFAAPLLIRLLSNPVASDPAanevgITFVRYF 405
Cdd:cd13143 58 LMIGVGGASLISRRL--GAGDREKANRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYA-----VDYLRII 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1759038063 406 LPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIVIIVTLGLFIWVYG 454
Cdd:cd13143 131 LLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNIILDPLFIFVLG 179
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
498-630 |
8.99e-03 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 39.11 E-value: 8.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1759038063 498 FRLRLRFDWRG----HGLGKAITLAkwTVLFVLANQAGAMIViqlstaaGKASPVDGTGFaaYANAQLIWGLPQAIITVS 573
Cdd:pfam13440 163 WRPRLTFSLKVikelFSFGSWLLLS--NLLNYLARNLDNLII-------GKVLGTAALGL--YSVAYRLALLPTANITSV 231
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1759038063 574 LMAALLPRISRSasEEDGGAVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMFGS 630
Cdd:pfam13440 232 ITKVLFPALSRI--QDDKAKLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVLLGS 286
|
|
| |
