|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
23-382 |
4.80e-85 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 262.88 E-value: 4.80e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 23 ALASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYY 102
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 103 LTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGFLPFAVGAGVILL 182
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 183 SAIPIFLARNESPVLDEKPKRHFMRYVFLVPTATAAVFIFGAVEYGGLSLFPIFGTRAGFSESQAALLLTVMGVGNFIFQ 262
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 263 IPLGMLSDRVkDRRTILSALTLIGLVGALFLPTLVENWFLMALVLLFWGGCVSGLYTVGLSHLGSRLQGADLAAANAAFV 342
Cdd:cd17477 241 WPLGWLADRF-DRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALL 319
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1775861208 343 FSYAVGTVAGPQVIGAAMDVTGNDGFAWAIAGFFGLYVVL 382
Cdd:cd17477 320 LLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-387 |
3.41e-33 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 128.07 E-value: 3.41e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 1 MSKPPPGTSGPVDEIHWPSLIAALASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRH 80
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 81 GVAPTMLLAIMFAAASSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATApPNRRGFVLGIYGTVLSLGFASGPL 160
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 161 LFS-ILGSEGF-LPFAVGAGVILLSAIP-IFLARNESPVLDEKPKRHFMRYVFLVPTA---TAAVFIFGAVEYGGLSLFP 234
Cdd:COG2807 160 LTVpLAAALGWrGALAVWALLALLALLLwLPLLRRRPAAAAAAPAAASLRSLWRSPLAwllTLFFGLQSLLYYAVVAWLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 235 IFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTIL---SALTLIGLVGALFLPTlvenwFLMALVLLFWG 311
Cdd:COG2807 240 PILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLlllGLLGLAGLLGLLLAPG-----SLPWLWAVLLG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1775861208 312 GCVSGLYTVGLSHLGSRLQGADLAAANAAFVFS-YAVGTVAGPQVIGAAMDVTGNDGFAWAIAGFFGLYVVLSLVRI 387
Cdd:COG2807 315 LGQGGLFPLALTLIGLRARTPAEAAALSGMAQSvGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-328 |
1.24e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 100.43 E-value: 1.24e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 17 WPSLIAALASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAAS 96
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 97 SLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEG--FLPFA 174
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgwRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 175 VGAGVILLSAIPIFLARNESPVLDEKPKRHFMRYVFLVPTATAAVFIFGAVEYGGLSLF----PIFGTRAGFSESQAALL 250
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFtylpLYLQEVLGLSASAAGLL 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1775861208 251 LTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLvgALFLPTLVENWFLMALVLLFWGGCVSGLYTVGLSHLGSR 328
Cdd:COG2814 249 LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL--GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-387 |
2.50e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 97.26 E-value: 2.50e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 24 LASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYL 103
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 104 TNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGFL--PFAVGAGVIL 181
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYraPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 182 LSAIPIFLARNESPVLDEK---------PKRHFMRYVFLVPTATAAVFIFGAVEYGGLSLFPIFGT-RAGFSESQAALLL 251
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKravsaarlrSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAeLGGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 252 TVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLvgALFLPTLVENWFLMALVLLFWGGCVSGLYTVGLSHLGSRLQG 331
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV--ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1775861208 332 ADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTGNDGFAWAIAGFFGLYVVLSLVRI 387
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-394 |
2.01e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 79.92 E-value: 2.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 15 IHWPSLIAALASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAA 94
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 95 ASSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEG--FLP 172
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFgwRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 173 FAVGAGVILLSAIPIFLARNESPVLDEKPKR---HFMRYVFLVPTATAAVFIFGAVEYGGLSLF----PIFGTRAGFSES 245
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAAAKaslRDQLEALRDPRFWLLSLLYFGTFGSFIGFSswlpPYLVDQFGLSAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 246 QAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGlVGALFLPTLVENWFLMALVLLFWGGCVSGLYTVGLSHL 325
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA-LGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1775861208 326 GSRLQGADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTGNDGFAWAIAGFFGLYVVLSLVRIVLKPKRP 394
Cdd:COG2223 321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-353 |
2.05e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.77 E-value: 2.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 23 ALASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYY 102
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 103 LTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGF--LPFAVGAGVI 180
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwrAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 181 LLSAIPIFLARNESPVLDEKPKRHFMRYVFL---------VPTATAAVFIFGAVEYGGLSLFPIFGTRAGFSESQAALLL 251
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVawkallrdpVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 252 TVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLVG-ALFLPTLVENWFLMALVLLFWGGCVSGLYTVGLSHLGSRLQ 330
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|...
gi 1775861208 331 GADLAAANAAFVFSYAVGTVAGP 353
Cdd:pfam07690 322 KEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
40-385 |
3.48e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 79.14 E-value: 3.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 40 LLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYLTNFWLWFPLRIVFHGA 119
Cdd:COG2271 32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 120 ITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEG--FLPFAVGAGVILLSAIPIFLArnespvl 197
Cdd:COG2271 112 EAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFgwRAAFLILGLPGLLLALLRFWL------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 198 dekpkrhfmryvflvptATAAVFIFGAVEYGGLSLFPIFGTRA-GFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRR 276
Cdd:COG2271 185 -----------------LALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 277 TILSALTLIGLVGALFLPTLVENWFLMALVLLFWGGCVSGLYTVGLSHLGSRLQGADLAAANAAFVFSYAVGTVAGPQVI 356
Cdd:COG2271 248 KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLV 327
|
330 340
....*....|....*....|....*....
gi 1775861208 357 GAAMDVTGNDGFAWAIAGFFGLYVVLSLV 385
Cdd:COG2271 328 GYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
16-385 |
4.63e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.13 E-value: 4.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 16 HWPSLIAALASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAA 95
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 96 SSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWInATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGF----- 170
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV-AALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLslswh 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 171 LPFAVGAGVILLSAIPIFLAR------NESPVLDEKPKRHFMRYVFLVPTATAAVFIFGAVEYGGLSLFPIFGT-RAGFS 243
Cdd:COG0738 165 LPYLILAVLLLLLALLFLRSKlpeieeEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKdVLGLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 244 ESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTIL--SALTLIGLVGALFLPtlveNWFLMALVLLFWGGCVSGLYTVG 321
Cdd:COG0738 245 EATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRlsALLAAVGLLLALLAP----GPWLALIGLALVGLGLSLMFPTI 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1775861208 322 LSHLGSRLQGADLAAANAAFVFSYaVGTVAGPQVIGAAMDVTGNDGFAWAIAGFFGLYVVLSLV 385
Cdd:COG0738 321 FSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-378 |
2.83e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 70.53 E-value: 2.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 29 AVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYLTNFWL 108
Cdd:cd06174 7 LTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 109 WFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEG----FLPFAVGAGVILLSA 184
Cdd:cd06174 87 LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfgwRAVFLIAAALALLAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 185 IPIFLARNESP--------VLDEKPKRHFMRYVFLVPTATAAVFIFGAVEYGGLSLFPIFGT----RAGFSESQAALLLT 252
Cdd:cd06174 167 ILLLLVVPDPPesarakneEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLflldLGGLSVAVAGLLLS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 253 VMGVGNFIFQIPLGMLSDRVKDRRTILsALTLIGLVGALFLPTLVENWFLMALVLLFWGGCVSGLYTVGLSHLGSRLQGA 332
Cdd:cd06174 247 LFGLAGALGSLLLGLLSDRLIGRKPLL-LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPE 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1775861208 333 DLAAANAAFVFSYAVGTVAGPQVIGAAMDVTGNDGFAWAIAGFFGL 378
Cdd:cd06174 326 IRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-308 |
2.11e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 67.62 E-value: 2.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 30 VGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYLTNFWLW 109
Cdd:cd17489 8 FFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 110 FPLRIvFHGAITVLFILSEF-WINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGFLP--FAVGAGVILLSAIP 186
Cdd:cd17489 88 LVLRL-IHGIGWGAFTTAAAtLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAvlFIVAAVLALLALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 187 IFLARNESPVLDE------KPKRHFMRYVFLVPtatAAVFIFGAVEYGGLSLF-PIFGTRAGFseSQAALLLTVMGVGNF 259
Cdd:cd17489 167 VFLVKDPPPVAAEeaeagtRAFRRLVEKKVLPP---ALILFLASIAYGAISTFlPLYAAERGI--SNAGLFFTVYAIALL 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1775861208 260 IFQIPLGMLSDRVKDRRTILSALTLIGLVGALFLPTLVENWFLMALVLL 308
Cdd:cd17489 242 LSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLY 290
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
39-384 |
2.34e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.57 E-value: 2.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 39 PLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYLTNFWLWFPLRIVFHG 118
Cdd:cd17324 20 GLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 119 AITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEG---FLPFAVGAGVILLSAIPIFLARNESP 195
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLgwrAAFLAIAVLALLAALLLWRLLPSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 196 VLDEKPKRHFMRYVFLVPTATAAVFIFGAVEYGGLSLF-----PIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSD 270
Cdd:cd17324 180 KKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALytylaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 271 RVKdRRTILSALTLIGLVGALFLPTLvENWFLMALVLLFWGGCVSGLYtVGLSHLGSRLQGADLAAANAAFVFSYAVGTV 350
Cdd:cd17324 260 RGG-RRALLIALLLLAAALLLLTLLG-PSPLLLLVGLVLWGLGFFAAH-SALQTRVLRLAPEARGLASSLYLAAYNLGGA 336
|
330 340 350
....*....|....*....|....*....|....
gi 1775861208 351 AGPQVIGAAMDVTGNDGFAWAIAGFFGLYVVLSL 384
Cdd:cd17324 337 LGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
16-387 |
1.21e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 62.67 E-value: 1.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 16 HWPSLIAALASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAA 95
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 96 SSLGFYYLTNFW----LWFPLRIVFHGAITVLFILSefwINATAPPNRRGFVLGIygtvLSLGFASGPLLFSILGS---- 167
Cdd:cd17355 81 GLVLLALATSLWqlylLWGLLGGGGAGTLAAVAFAT---VAAWWFERRRGLALGI----LTAGGGLGSLVFLPLGAalie 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 168 -----EGFLPFAVGAGVILLSAIPIFLARNESPVLDEKPKRHFMRYVFLVPTA---------TAAVFIFGAVEYGGLSLF 233
Cdd:cd17355 154 afgwrTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEAlrsasfwllALAFFLCGFAVVGLIVHL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 234 PIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVkDRRTILSALTLIGLVGALFLPTLVENWFLMALVLLFWGGC 313
Cdd:cd17355 234 VPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRY-SPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1775861208 314 VSGLYTVGLSHLGSRLQGADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTGNDGFAWAIAGFFGLYVVLSLVRI 387
Cdd:cd17355 313 WGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
38-385 |
1.91e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.83 E-value: 1.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 38 LPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYLTNFWLWFPLRIvFH 117
Cdd:cd17330 19 LPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARF-LD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 118 GAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEG--FLPFAVGAGVILLSAIPIFLarnesp 195
Cdd:cd17330 98 GLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYgyALPFLVAAALALLNLVLVLF------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 196 vldekpkrhFMRYVFLVPTATAAVFIFGAVEYGGLSLFPIfgTRAGFSESQAALLLTVMGVGNFIFQIPL-GMLSDRVKD 274
Cdd:cd17330 172 ---------FLPPLRRLLLVYFLIALAFAGLESVFSLFLK--DRFGFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 275 RRTILSA--LTLIGLVGALFLPTLVENWFLMALVLLFWGGCVSGLYTVGLSHLGSRLQGADLAAANaafvFSYAVGTVAG 352
Cdd:cd17330 241 RKLLRLGllLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQ----SLQSLARIIG 316
|
330 340 350
....*....|....*....|....*....|...
gi 1775861208 353 PQVIGAAMDVTGNDGFAWAIAGFFGLYVVLSLV 385
Cdd:cd17330 317 PLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-191 |
8.47e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.90 E-value: 8.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 15 IHWPSLIAALASITAVGIAIGLGLPLLSVIMEKR-GIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFA 93
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 94 AASSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEG--FL 171
Cdd:cd17325 276 AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFgfAT 355
|
170 180
....*....|....*....|
gi 1775861208 172 PFAVGAGVILLSAIPIFLAR 191
Cdd:cd17325 356 PFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
39-309 |
2.99e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 57.95 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 39 PLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYLTNFWLWFPLRIV--- 115
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALagi 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 116 ----FHGAITVLFilsefwinATAPPNRRGFVLGIYGTVLSLGFASGPL----LFSILGSEGFLPFAVGAGVILLSAIPI 187
Cdd:cd17478 97 gsaaFHPEGARLA--------SQAAGGRRGLAMSIFSVGGNLGFALGPLiaaaLVALFGGLGLLILLIIPGLAVALLLLR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 188 FLARNESPVLDEKPKRHFMRYVFLVPTA----TAAVFIFGAVEYGGLSLFPIFGTRAGFSESQAALLLTVMGVGNFIFQI 263
Cdd:cd17478 169 LRPLKKPEAKKAAAKSSARSTLKGVWRAllllLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTL 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1775861208 264 PLGMLSDRVKDRRTILSALTLIGLVGALFLptLVENWFLMALVLLF 309
Cdd:cd17478 249 IGGPLSDRFGRRRVIIASLLLAAPFLLLFL--LTPGIWSYILLVLA 292
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
29-384 |
1.19e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.48 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 29 AVGIAIGLGLPLLSVIM-EKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYLTNFW 107
Cdd:cd17475 6 AAASLVAQGIPALAPFLqEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 108 LWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGFLP--FAVGAGVILLSAI 185
Cdd:cd17475 86 VLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRaaFVVAGLVSILAAV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 186 PIFLARNESPVLDEKPK---------RHFMRYVFLVPTATAAVFIfGAVEYGGLSLFPIFGT-RAGFSESQAALLLTVMG 255
Cdd:cd17475 166 LFWLFYREPPAASAATEsastllrslKEVLRNRDVWLIAIAGALL-VAPQFALLTFLLLFLHdHLGLSVVAAGALLAVAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 256 VGNFIFQIPLGMLSDRVKDRR-----TILSALTLIGLVGALFLPTLVENWFLMALVLLFWGGCVS--GLYTVGLSHLGSR 328
Cdd:cd17475 245 LGGALGRIGLGRVSDRVFGGRrrpvlVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGwnGLYLTLVAESAGP 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1775861208 329 LQGADLAAANAAFVFsyaVGTVAGPQVIGAAMDVTGNDGFAWAIAGFFGLYVVLSL 384
Cdd:cd17475 325 EQAGTALGLANTINF---IGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
24-308 |
2.09e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 52.55 E-value: 2.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 24 LASITAVGIAIGLGLPLLSV-IMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVA-PTMLLAIMFAAASSLGFY 101
Cdd:cd17471 2 LLATLLTGLAGAFVLPYLSLfLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRkPLILLALLAGALGYLLFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 102 YLTNFWLWFPLRIVFHG----AITVLFILSEFWINATaPPNRRGFVLGIYGTVLSLGFASGPLL-FSILGSEGFLP-FAV 175
Cdd:cd17471 82 FLRNYWVLLLVGVVLLSlgaaAFPQLFALAREYADRS-SGRDATLFNSVLRAAFSLAWVIGPPLaFLLLDVLGFTGlFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 176 GAGVILLSAIPIFL-------ARNESPVLDEKPKRHFMRYVFLVptaTAAVFIFGAVEYGGLSLFPIFGTRA-GFSESQA 247
Cdd:cd17471 161 AALLYLVVALLVLFllpsvkpPAQKATPASSLVKAPVNRRLLLL---FAAFTLLFAANSMYIIAMPLYVTNElGGSESWV 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1775861208 248 ALLltvMGVGNFI---FQIPLGMLSDRVKDRRTILSALtLIGLVGALFLPTLVENWFLMALVLL 308
Cdd:cd17471 238 GLL---FGLAAALeipIMLLAGLLAKRFGKRRLLLAGF-LAGVLFYLGLALATSLWQLIALQLL 297
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
24-308 |
4.40e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.46 E-value: 4.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 24 LASITAVGIAIGLGLPLLSVIM-EKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYY 102
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 103 LTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGF-LPFAVGAGVIL 181
Cdd:cd17329 85 AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFrLLFLAAAVLFL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 182 LSAIPIFLARNESPVLDEKPKRH---------FMRYVFLvpTATAAVFIFGAVEYGGLSLFPIFGTRA-GFSESQAALLL 251
Cdd:cd17329 165 LAALVLLFLLPETRPKRRAAEKTeilrgykivLRDRAFL--LFLLASFLISLIYFQLESTLPVYVVEIlGLGESLLGLLL 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1775861208 252 TVMGVGNFIFQIPLGMLSDRVKDRRTILSALTL--IGLVGALFLPTLVenWFLMALVLL 308
Cdd:cd17329 243 ALNALLIVLLQFPVARLVERFRLRKILMIGILLfaIGFAVLAFANTLA--VLILAMIVL 299
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
131-325 |
9.58e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.25 E-value: 9.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 131 INATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSegflpfAVGAGVILLSAIPI-----FLARNESpvldekpkrhf 205
Cdd:cd17321 109 IAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE------LFGWRWIFLINVPIglvalLLARTFS----------- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 206 mryvflvpTATAAVFIFGAVEYGGLSLFPIFGTRA-GFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTL 284
Cdd:cd17321 172 --------GAVLAAFLLGAALGGLLFLLPLYLQGVlGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLL 243
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1775861208 285 IGLVGALFLPTLVENWFLMALVLLFWGGCVSGLYTVGLSHL 325
Cdd:cd17321 244 TAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNA 284
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
25-315 |
1.41e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 25 ASITAVGiaiglglPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLgFYYLT 104
Cdd:cd17339 13 PAITSVG-------PLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGIL-LRSLG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 105 NFWLWFPLRIVFHGAITVLFILSEFWINATAPpNRRGFVLGIYGTVLSLGFA-----SGPLLFSILGS--EGFLPFAVGA 177
Cdd:cd17339 85 GIALLFLGTALAGAGIAVGNVLLPSLIKRDFP-RRVGLMTGLYTTSMNLGAAlasglSVPLAQALGGGwrGALAIWALPA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 178 GVILLSAIPIFLARNE-SPVLDEKPKRHFMRYvflvPTATAAVFIFG---AVEYGGLSLFPIFGTRAGFSESQAALLLTV 253
Cdd:cd17339 164 LLALLIWLPQLRRRKRaAAAAAPLTKISVWRS----PLAWQVTLFMGlqsLLFYTLMAWLPTILIDAGLSAATAGWLLSL 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1775861208 254 MGVGNFIFQIPLGMLSDRVKDRR---TILSALTLIGLVGALFLPTLVeNWFLMALVLLFWGGCVS 315
Cdd:cd17339 240 FQLVGIPASLLVPILATRLKNQRpivVLLAVLFIIGVLGLLFAPTAL-ALLWAVLLGLGGGAAFS 303
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
21-307 |
1.46e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 21 IAALASITAVG-IAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLG 99
Cdd:cd17474 1 LYAVFFATLLAvLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 100 FYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEG-FLPFA-VGA 177
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISwRYPFFlLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 178 GVILLSAIPIFLARNESPVLDEKPKRHFMRYVFLVPTATAAVFIFGAVEY-----GGLSLFPIF-GTRAGFSESQAALLL 251
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYfflyfAFLTYLPFLlELLYGISPIIIGLLF 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1775861208 252 TVMGVGNFIFQIPLGMLSDRVKDRRTIL---SALTLIGLVGALFLPTLVenWFLMALVL 307
Cdd:cd17474 241 AGWSVLLALGSLFVGRLLKKRFGARRILvigLLLYALSLLLLGFVPSLA--LLLIAIVL 297
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
81-385 |
2.20e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.52 E-value: 2.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 81 GVAPTMLLAIMFAAASSLGfyYLTNFWLWFPLRIVFHGAITVLFILSEFWINA-TAPPNRRGFVLGIYGTVLSLG----F 155
Cdd:COG2211 87 GAIPLALSFVLLFTAPDLS--PTGKLIYALVTYLLLGLAYTLVNIPYSALGAElTPDYEERTRLSSWRFAFAGLGgllaS 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 156 ASGPLLFSILGSEG----FLPFAVGAGVILLSAIPIFLARNESPVLDEKPK--RHFMRYVF----LVPTATAAVFIFGAV 225
Cdd:COG2211 165 VLPPPLVAAFGGDAalgyRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVslKESLKALLknrpFLLLLLAYLLFFLAL 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 226 EYGGLSLFPIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLVGALFLPTLVENWFLMAL 305
Cdd:COG2211 245 ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLV 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 306 VLLFWGGCVSGLYTVGLS-----------HLGSRLQGADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTGNDGFAWAIAG 374
Cdd:COG2211 325 LAALAGIGLGAILVLPWAmladvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTG 404
|
330
....*....|.
gi 1775861208 375 FFGLYVVLSLV 385
Cdd:COG2211 405 IRLLFFLLPAV 415
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-191 |
2.23e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.15 E-value: 2.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 16 HWPSLIAALASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAA 95
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 96 SSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGFLPFAV 175
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*.
gi 1775861208 176 GAGVILLSAIPIFLAR 191
Cdd:cd06173 367 LLAGALLLLAALLLLL 382
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
64-317 |
3.94e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.34 E-value: 3.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 64 LASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFV 143
Cdd:cd17503 42 LALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 144 LGIYGTVLSLGFASGPllfsILGseGFLPFAVGAGVILLSAIPI-FLARNESPVLDEKPkrhFMRYVFLVptATAAVFIF 222
Cdd:cd17503 122 MGLVGLVILLAPAIGP----TLG--GWLTDNLSWRWIFYINLPIgILALLLAPLLDLRL---FKDRNFTL--GLLLSFLL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 223 GAVEYGGLSLFPIF-GTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLVGALFLPTLVENWF 301
Cdd:cd17503 191 GLGLFGAMFLLPLYlQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSL 270
|
250
....*....|....*.
gi 1775861208 302 LMALVLLFWGGCVSGL 317
Cdd:cd17503 271 WLIILPLFIRGLGMGL 286
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
204-376 |
4.54e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 48.32 E-value: 4.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 204 HFMRYVFLVPTATAAVFIFgaveYGGLSLFPIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALT 283
Cdd:cd17352 181 KDPTFVLLALGVSFAMLGF----FVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFT 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 284 LIGLVGALFLPTLVENWFLMALVLLFWGGCVSGLYT---------VGLSHLGSRLqgadlaaanAAFVFSYAVGTVAGPQ 354
Cdd:cd17352 257 LLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSltpviladlVGLEKLSNAY---------GLVLLFQGLAALVGPP 327
|
170 180
....*....|....*....|..
gi 1775861208 355 VIGAAMDVTGNDGFAWAIAGFF 376
Cdd:cd17352 328 IAGLLRDYTGDYDAAFYFCGAC 349
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
30-309 |
4.98e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.03 E-value: 4.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 30 VGIAIGLGLPLLSVIMEKRGIAPTLN-----GLNAAMAGLASMAAAPFTMKFAHRHGVAPtMLLAIMFAAASSLGFY-YL 103
Cdd:cd17391 8 TGIGFSLIAPFLPLYIEQLGVTSGGLvelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKP-MLLRASLGMAIVIGLMaFV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 104 TNFWLWFPLRI---VFHGAITVLFILsefwINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSIL-GSEGFLP-FAVGAG 178
Cdd:cd17391 87 TNVWQLLILRLlqgVFSGYVPNATAL----IASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLaDLFGIRNvFFITGG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 179 VILLSAI-PIFLARNESPVLDEKPKRHFMRYVFLVPTATAAVFIFGA---VEYGGLSLFPI-------FGTRAGFSESQA 247
Cdd:cd17391 163 LLFLAFLlTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTtfiIQLANQSIEPIltlyirqLMGDASNLAFIS 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1775861208 248 ALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLVgaLFLPTLVEN-WFLMALVLLF 309
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALL--YIPQAFVQTpWQLGILRFLL 303
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
76-320 |
5.76e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.98 E-value: 5.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 76 FAHRHGVAPTMLLAIMFAAASSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGF 155
Cdd:cd17316 59 LGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGA 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 156 ASGPLLFSILGSEGFLPFAVGAgVILLSAIPIFLArnespvldekpkrHFMRYVFLVptATAAVFIFGAVEYGGLSLFP- 234
Cdd:cd17316 139 LLAALVASLLIPLLSGDWGWRI-LFLIGALPALLA-------------LLLRRRTLL--LILLWFFISFGYYGLTTFLPt 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 235 IFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLVGALFLPTLVENWFLMALVLLFWGGCV 314
Cdd:cd17316 203 YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFV 282
|
....*.
gi 1775861208 315 SGLYTV 320
Cdd:cd17316 283 GGVWGA 288
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
20-364 |
1.63e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 46.53 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 20 LIAALASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLG 99
Cdd:cd06180 1 LAGALALAVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 100 FYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILG------SEGFLPF 173
Cdd:cd06180 81 MALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLggglswRAGWLAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 174 AVGAGVILLSAIPIFLARNESPVlDEKPKRHFMRYVFLVPTATAAVFIFGAVEYGGLSLFPIFGTRAGFSESQAALLLTV 253
Cdd:cd06180 161 ALLSAVLLLLSFLLLRRGPSAPT-EASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 254 MGvgnfIFQIPLGMLSDRVKDRRTILSALTLIGLVGAL--FLPTLVENWFLMALVLLFWGGCVSGLYTVGLSHlGSRLQG 331
Cdd:cd06180 240 FG----LAAVPSCFLWGALSDRWGTRRALAANLLVQAVgvLLPLLSPGPAGLVLSAVLFGGTFMAITALVMAL-ARELAP 314
|
330 340 350
....*....|....*....|....*....|...
gi 1775861208 332 ADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTG 364
Cdd:cd06180 315 PAAPRALALMTASFGVGQILGPLLAGWLADATG 347
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
13-191 |
2.16e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.03 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 13 DEIHWPSLIAALASITAVGIAIGLGLPLLSVIMEKRGIA-PTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIM 91
Cdd:cd17473 192 AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGsAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 92 FAAASSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGF- 170
Cdd:cd17473 272 LMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGg 351
|
170 180
....*....|....*....|...
gi 1775861208 171 --LPFAVGAGVILLSAIPIFLAR 191
Cdd:cd17473 352 lsGAFLILGVLALVLAIVLLLLR 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
210-387 |
2.94e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 210 FLVPTATAAVFIFGAVEYGGLSLFPIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLVG 289
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 290 ALFLptLVENWFLMALVLLFWGGCVSGLYTVGLSHLGSRLQGADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTGNDGFA 369
Cdd:COG2814 90 LLCA--LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170
....*....|....*...
gi 1775861208 370 WAIAGFFGLYVVLSLVRI 387
Cdd:COG2814 168 LVNAVLALLALLLLLRLL 185
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
16-297 |
3.75e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.19 E-value: 3.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 16 HWPSLIAALASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAA 95
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 96 SSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGF--LPF 173
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGwrWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 174 AVGAGVILLSAIPIFLARNESPVLDEKPKRHFMRYVFLVPTATAAVFIFGAVEYGGLSLFPIFGTRAGFSESQAALLLTV 253
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1775861208 254 MGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLVGALFLPTLV 297
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
135-318 |
6.26e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.83 E-value: 6.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 135 APPNRRGFvlgiYGTVLSLGFASGPLL--------FSILGSEGFL------PFAVGAgVILLSAIPIFLARNESPV---- 196
Cdd:cd17369 134 APPKRRGF----YGSFPQLGAPVGLLLatgvflllSALLSDEAFLswgwriPFLLSA-VLVAVGLYIRLRLEETPVfrra 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 197 --LDEKPKRHFMRYVFLVPTATAAVFIFGAVEYGGLSLFPIFG-----TRAGFSESQAALLLTVMGVGNFIFQIPLGMLS 269
Cdd:cd17369 209 keAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFAlsyatQTLGVDRSTVLLAVLIASVVAAITIPLFGWLS 288
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1775861208 270 DRVkDRRTILSALTLIGLVGALFLPTLVE--NWFLMALVLLFWGGCVSGLY 318
Cdd:cd17369 289 DRV-GRRPVYLAGALLAALFAFPFFWLLDtgSTWLIVLAAVVVLGVLHGMM 338
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
16-189 |
9.55e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 9.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 16 HWPSLIAALASITAVGIAIGLGLPLLSVIMEKR-GIAPTLNGLNAAMAGLASMAAAPFTMKF-AHRHGVAPTMLLAIMFA 93
Cdd:cd17474 196 RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLY 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 94 AASSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGFL-- 171
Cdd:cd17474 276 ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLsa 355
|
170
....*....|....*...
gi 1775861208 172 PFAVGAGVILLSAIPIFL 189
Cdd:cd17474 356 PFLVGAAIALAAAVLLAL 373
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-185 |
1.01e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 20 LIAALASITAVGIAIGLGLPLlsVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLG 99
Cdd:cd17329 205 FLLASFLISLIYFQLESTLPV--YVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAV 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 100 FYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSILGSEGF--LPFAVGA 177
Cdd:cd17329 283 LAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGpgLPWLILA 362
|
....*...
gi 1775861208 178 GVILLSAI 185
Cdd:cd17329 363 ALGLIAAA 370
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
130-316 |
1.24e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 43.64 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 130 WINATAPPNRRGFVLGIYGTVLSLGFAS-GPLLFSI----LGSEGFLPFAVGAgVILLSAIPIFLARNESPV-----LDE 199
Cdd:cd17337 113 WITYRTPAERLGSAVGWFWFAFTGGLPVlGSYLASFtipvIGEIGTLWLSLVF-VALGGLIALFLVRDRTGEqplanPSE 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 200 KPKRHFMRYVFLV----PTATAAV--FIFGAVEYGGLSLFPIFGTRA-GFSESQAALLLTVMGVGNFIFQIPLGMLSDRV 272
Cdd:cd17337 192 EPLKELLSGITILfrnpKIAIGGIvrIINTLSQFGFPVFMPLYFTDTgGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKI 271
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1775861208 273 KDRRTI------LSALTLIGLvgaLFLPTLV-ENWFLMALVLLFWGGCVSG 316
Cdd:cd17337 272 GWRRTVrwfggvGCAISTLLF---YYVPQLFgHNYWAALIAAILFGIGLAG 319
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
220-386 |
3.28e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 3.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 220 FIFGAVEYGGLSLFPIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLVGALFLPTlveN 299
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT---P 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 300 WFLMALVLLFWGGCVSGLYTVGLSHLGSRLQGADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTGNDGFAWAIAGFFGLY 379
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLL 162
|
....*..
gi 1775861208 380 VVLSLVR 386
Cdd:cd17333 163 LAILILL 169
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
214-394 |
6.50e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 6.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 214 TATAAVFIFGAVEYGGLSLFPIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLvgALFL 293
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL--GLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 294 PTLVENWFLMALVLLFWGGCVSGLYTVGLSHLGSRLQGADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTGNDGFAWAIA 373
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180
....*....|....*....|.
gi 1775861208 374 GFFGLYVVLSLVRIVLKPKRP 394
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKR 179
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
24-362 |
7.13e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.41 E-value: 7.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 24 LASITAVGIAIGLGLPLLSVIMEKRGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYL 103
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 104 TNFWLWFPLRIVfHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVLSLGFASGPLLFSI----LGSEGFLPFAVGAGV 179
Cdd:cd17504 82 PNLPVLIAGRAL-QGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWivqhLGWRWIFWTAAPVAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 180 ILLSAIPIFlarnespvldekPKRHFMRYVFLVPTATAavFIFGAVEYGGLSLFPIF-----GTRAGFSESQAALLLTVM 254
Cdd:cd17504 161 LLAALVPLI------------DLRLLRRRNVLLANITA--LLAGFGMFMVFQLLPQLlqlptPTGFGLGITEAGLLLLPG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 255 GVGNFIFQIPLGMLSDRVKDRRTIL--SALTLIGLVGALFLPT-LVENWFLMALVLLFWGGCVSGLYTVGLSHLGSRLQG 331
Cdd:cd17504 227 ALVMLIAGPLAGRLIARVGPRRVLLigLVISAVGLLLLALLHSsLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTG 306
|
330 340 350
....*....|....*....|....*....|.
gi 1775861208 332 ADLAAANAAFVfsyaVGTVAGPQVIGAAMDV 362
Cdd:cd17504 307 IATGMNTVLRT----IGSAIGPAIAGAILTT 333
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
72-360 |
1.42e-03 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 40.41 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 72 FTMKFAHRHGVAPTMLLAIMFAAASSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPNRRGFVLGIYGTVL 151
Cdd:PRK03633 60 LAGYVIKRIGFNRSYYLASLIFAAGCAGLGLMVGFWSWLAWRFVAGIGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVY 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 152 SLGFASGPLLFSILGSEGFLPFAVGAGVILLSAIPIFLARNESPVLDEKPKRHF-----MRYVFLvptATAAVFIFGAVE 226
Cdd:PRK03633 140 YLGTVLGQLLVSKVSTELMSVLPWVTGLVLAAILPLLFTRILNQQAENHDSTSIwpmlkLRQARL---GVNGCIISGIVL 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 227 YGGLSLFPIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVkDRRTILSALTLIGLVGALFLPTLVenwfLMALV 306
Cdd:PRK03633 217 GSLYGLMPLYLNHQGMSDASIGFWMALLVSAGILGQWPIGRLADRF-GRLLVLRVQVFVVILGSIAMLSQA----AMAPA 291
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1775861208 307 LLFWGGCVSGLYTVGLSHLGSRLQGADLAAANAAFVFSYAVGTVAGPQVIGAAM 360
Cdd:PRK03633 292 LFILGAAGFTLYPVAMAWACEKVEHHELVAMNQALLLSYTVGSLLGPSFTAMLM 345
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
59-381 |
1.97e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.09 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 59 AAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLGFYYLTNFWLWFPLRIVFHGAITVLFILSEFWINATAPPN 138
Cdd:cd17314 44 ASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPD 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 139 RRGFVLGIYGTVLSLG-FASGPLLFSILGSEGFLPFAVGAGVILLSAIPIFL-------ARNESPVLDEKPKRHFMRYVF 210
Cdd:cd17314 124 TKGLALGLPTTGYSLGlVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSllgfkepPDNQARLHVQKKKTQTMGEIF 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 211 LVPTATAAVFIFGAVEYGGLSLFPIFGTRAGFSESQAA----LLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIG 286
Cdd:cd17314 204 RDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPsfvtKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTIL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 287 LVG--ALFLPTLVENWFLMALVLLFwGGCVSGLYTVGLSHLGSRLQGADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTG 364
Cdd:cd17314 284 GLGlcAFLFLLKMTPVGLVLTGSLL-GFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTP 362
|
330
....*....|....*..
gi 1775861208 365 NDGFAWAIAGFFGLYVV 381
Cdd:cd17314 363 SYISAVYIYAVIVFLAS 379
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
20-190 |
2.40e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.89 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 20 LIAALASITAVGIAIGLGLPLLSVIMekrGIAPTLNGLNAAMAGLASMAAAPFTMKFAHRHGVAPTMLLAIMFAAASSLG 99
Cdd:COG2211 234 LLAYLLFFLALALVAALLLYYFKYVL---GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 100 FYYL--TNFWLWFPLRIVFHGAITVLFILSEFWINATAPP-------NRRGFVLGIYGTVLSLGFASGPLLFS-ILGSEG 169
Cdd:COG2211 311 LFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALAGlLLALFG 390
|
170 180
....*....|....*....|....*..
gi 1775861208 170 FLP------FAVGAGVILLSAIPIFLA 190
Cdd:COG2211 391 YVAgaaqspSALTGIRLLFFLLPAVLL 417
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
173-331 |
2.51e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 39.52 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 173 FAVGAGVILLSAIPIFLARNESPV------LDEKPKRHFMRYVFLVPTATAA---VFIFGAVEYGGLSLFPIFGTRAGFS 243
Cdd:cd17485 161 LLSLAALYLLLLLPVLFLRELELPqqppasERGAALKASLRAFLRRPGTRWLllfLLLYKLGEQGALAMLPPFLVDRGFS 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 244 ESQAALLLTVMGVGNFIFQIPL-GMLSDRVKDRRTILSALTL--------IGLVGALFLPTLVENWFLMALVLLFWGGCV 314
Cdd:cd17485 241 LSQIGLLSGVGGSLVSIAGSLLgGYLLKRRGRRRLLLLGGLLrllllglyTLLALGGSGLNWVLLLASLALLHLVGGMIT 320
|
170
....*....|....*..
gi 1775861208 315 SGLYTVGLSHLGSRLQG 331
Cdd:cd17485 321 TALFTLMMDCSQQAQAG 337
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
216-394 |
3.64e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.07 E-value: 3.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 216 TAAVFIFGAVEYGGLSLFPIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVkDRRTILSALTLIGLVGaLFLPT 295
Cdd:cd17324 5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRI-ERRRLLLVLLLLFILG-NLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 296 LVENWFLMALVLLFWGGCVSGLYTVGLSHLGSRLQGADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTgndGFAWAIAGF 375
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL---GWRAAFLAI 159
|
170
....*....|....*....
gi 1775861208 376 FGLYVVLSLVRIVLKPKRP 394
Cdd:cd17324 160 AVLALLAALLLWRLLPSLP 178
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
135-311 |
3.76e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 135 APPNRRGFVLGIYGTVLSLGFASGPLL-FSILGSEGF---LPFAVGAGVILLSAIPIFLARNESP------VLDEKPKRH 204
Cdd:cd17370 117 TPPSGRGKAFGLHRALDTLGAVLGPLLaALLLYLLGGnyrTIFLLAAIPALLALLILLFVVKEYPrppklrKKSKKTSLK 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 205 FMRYVFLVPTATAAVFIFGAVEYGGLSLFpifGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTL 284
Cdd:cd17370 197 KLPKAFWLYLLAVALFALGNFSFAFLILR---AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLS 273
|
170 180
....*....|....*....|....*..
gi 1775861208 285 IGLVGALFLptLVENWFLMALVLLFWG 311
Cdd:cd17370 274 LALAYLGFA--LGSSLWLLLLGFILWG 298
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
140-312 |
7.02e-03 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 38.45 E-value: 7.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 140 RGFVLGIYGTVLSLGFASGPLLFSILGSEGF-LPFAVGAGVILLSAIPIFLARNESPvldekPKrhfmryvfLVPTATAA 218
Cdd:cd17342 156 RGFVLGLWSACASVGNIIGALLASSVLDYGYeYAFLVTSSLLFAGAIVVFFGLLSSP-----PG--------VIPYSLAY 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 219 VFIfGAVEYGGLSLFPIFGTRA-GFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKdRRTILSALTLIGLVGALFL---- 293
Cdd:cd17342 223 ACL-KLVNYSFFFWLPFYLSNNfHWKESEADQLSIWYDVGGIIGGIVAGYISDRMG-SRSPVVVVMLLLAIPSLFVyshs 300
|
170 180
....*....|....*....|
gi 1775861208 294 -PTLVENWFLMALVLLFWGG 312
Cdd:cd17342 301 pSDKVLNAFVMTITGFFIGG 320
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
220-394 |
7.15e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.18 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 220 FIFGAVEYGGLSLFPIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLVGALFlpTLVEN 299
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF--AFAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 300 WFLMALVLLFWGGCVSGLYTVGLSHLGSRLQGADLAAANAAFVFSYAVGTVAGPqVIGAAMDVTGNDGFAWAIAGFFGLY 379
Cdd:cd06174 84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGP-LLGGILASSLGFGWRAVFLIAAALA 162
|
170
....*....|....*
gi 1775861208 380 VVLSLVRIVLKPKRP 394
Cdd:cd06174 163 LLAAILLLLVVPDPP 177
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
232-394 |
7.34e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 7.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 232 LFPIFGTRAGFSESQAALLLTVMGVGNFIFQIPLGMLSDRVKDRRTILSALTLIGLVGALFLPTlveNWFLMALVLLFWG 311
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA---PNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775861208 312 GCVSGLYTVGLSHLGSRLQGADLAAANAAFVFSYAVGTVAGPQVIGAAMDVTGNDGFAWAIAgfFGLYVVLSLVRIVLKP 391
Cdd:cd17478 95 GIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLI--IPGLAVALLLLRLRPL 172
|
...
gi 1775861208 392 KRP 394
Cdd:cd17478 173 KKP 175
|
|
| |
