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Conserved domains on  [gi|1799545454|gb|QHM71166|]
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hypothetical protein C7M51_01449 [Mixta intestinalis]

Protein Classification

energy transducer TonB( domain architecture ID 11484971)

energy transducer TonB interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10819 PRK10819
transport protein TonB; Provisional
 1-243 6.06e-95

transport protein TonB; Provisional


:

Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 278.10  E-value: 6.06e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454   1 MTTLTTPLPRRLSIPVLLSVVLHGSVIAALLYTSFHQVIEAPKTSQPISVSLVAPEVQPEPQSAPPQAAPEPQPEPEPEP 80
Cdd:PRK10819    1 MTLMTLDLPRRFPWPTLLSVGLHGAVVAGLLYTSVHQVIELPAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454  81 VPEPPKPEPVAIPKPKPKPKPKPVKKEVVKPRKEVKPH-----TEPRQASPFDNDNPlsASARPSTAPTRSSAPSRSIST 155
Cdd:PRK10819   81 IPEPPKEAPVVIPKPEPKPKPKPKPKPKPVKKVEEQPKrevkpVEPRPASPFENTAP--ARPTSSTATAAASKPVTSVSS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454 156 GPRALSVGKPAYPARAFALRIEGRVRVQYDVDSDGRVDNIRILSAQPRNMFERDVKQAMRKWRYESGKPGSNLTMTIVFR 235
Cdd:PRK10819  159 GPRALSRNQPQYPARAQALRIEGQVKVKFDVDEDGRVDNVRILSAEPRNMFEREVKQAMRKWRYEAGKPGKGLVVNIVFK 238


                  ....*...
gi 1799545454 236 INGGTSME 243
Cdd:PRK10819  239 INGTTEIE 246
 
Name Accession Description Interval E-value
PRK10819 PRK10819
transport protein TonB; Provisional
 1-243 6.06e-95

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 278.10  E-value: 6.06e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454   1 MTTLTTPLPRRLSIPVLLSVVLHGSVIAALLYTSFHQVIEAPKTSQPISVSLVAPEVQPEPQSAPPQAAPEPQPEPEPEP 80
Cdd:PRK10819    1 MTLMTLDLPRRFPWPTLLSVGLHGAVVAGLLYTSVHQVIELPAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454  81 VPEPPKPEPVAIPKPKPKPKPKPVKKEVVKPRKEVKPH-----TEPRQASPFDNDNPlsASARPSTAPTRSSAPSRSIST 155
Cdd:PRK10819   81 IPEPPKEAPVVIPKPEPKPKPKPKPKPKPVKKVEEQPKrevkpVEPRPASPFENTAP--ARPTSSTATAAASKPVTSVSS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454 156 GPRALSVGKPAYPARAFALRIEGRVRVQYDVDSDGRVDNIRILSAQPRNMFERDVKQAMRKWRYESGKPGSNLTMTIVFR 235
Cdd:PRK10819  159 GPRALSRNQPQYPARAQALRIEGQVKVKFDVDEDGRVDNVRILSAEPRNMFEREVKQAMRKWRYEAGKPGKGLVVNIVFK 238


                  ....*...
gi 1799545454 236 INGGTSME 243
Cdd:PRK10819  239 INGTTEIE 246
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 169-237 1.34e-15

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 69.25  E-value: 1.34e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1799545454 169 ARAFALRIEGRVRVQYDVDSDGRVDNIRILSAQPRNMFERDVKQAMRKWRYES-----GKPGSNLTMTIVFRIN 237
Cdd:TIGR01352   1 ARARRRGIEGTVVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRKARFEPppppgGVVAASVTIPVRFKLP 74
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
 165-236 2.63e-15

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 68.46  E-value: 2.63e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799545454 165 PAYPARAFALRIEGRVRVQYDVDSDGRVDNIRILSAQPRNMFERDVKQAMRKWRYESGKPGSN-----LTMTIVFRI 236
Cdd:pfam03544   3 PVYPEEARRRGIEGTVVVEFLIDPDGNVTNVRVVKSSGYSILDEAALEAVKKWRFKPAPKNGQpvtveITVPIRFKL 79
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 168-233 1.34e-12

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 61.06  E-value: 1.34e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454 168 PARAFALRIEGRVRVQYDVDSDGRVDNIRILSAQPRNMFERDVKQAMRKWRYE----SGKPGSNLTMTIV 233
Cdd:COG0810     1 PEEARRRGIEGTVTVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRRWRFKpakqNGKPVRVKTVPIR 70
myxo_SS_tail NF033768
AgmX/PglI C-terminal domain; The AgmX/PglI C-terminal domain described by this HMM ...
 176-235 7.13e-04

AgmX/PglI C-terminal domain; The AgmX/PglI C-terminal domain described by this HMM (myxo_SS_tail) occurs as the C-terminal domain in multiple proteins per genome for a number of species capable of surface gliding motility, e.g. 12 in Myxococcus xanthus. Member proteins include the adventurous gliding motility proteins AgmX (GltJ) and PglI in M. xanthus. The domain is about 92 amino acids long, and features a pair of Cys residues about 45 amino acids apart in almost all cases.


Pssm-ID: 468180  Cd Length: 92  Bit Score: 37.55  E-value: 7.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1799545454 176 IEGRVRVQYDVDSDGRVDNIRILSAQPRNM-FERDVKQAMRKWRYESGKPGS-NLTMTIVFR 235
Cdd:NF033768   31 LAGKVVVEFTIGPSGRVSSVKVVSSTLKDPkVESCILRRIKRWRFPKPKGGEvTVTYPFIFS 92
 
Name Accession Description Interval E-value
PRK10819 PRK10819
transport protein TonB; Provisional
 1-243 6.06e-95

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 278.10  E-value: 6.06e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454   1 MTTLTTPLPRRLSIPVLLSVVLHGSVIAALLYTSFHQVIEAPKTSQPISVSLVAPEVQPEPQSAPPQAAPEPQPEPEPEP 80
Cdd:PRK10819    1 MTLMTLDLPRRFPWPTLLSVGLHGAVVAGLLYTSVHQVIELPAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454  81 VPEPPKPEPVAIPKPKPKPKPKPVKKEVVKPRKEVKPH-----TEPRQASPFDNDNPlsASARPSTAPTRSSAPSRSIST 155
Cdd:PRK10819   81 IPEPPKEAPVVIPKPEPKPKPKPKPKPKPVKKVEEQPKrevkpVEPRPASPFENTAP--ARPTSSTATAAASKPVTSVSS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454 156 GPRALSVGKPAYPARAFALRIEGRVRVQYDVDSDGRVDNIRILSAQPRNMFERDVKQAMRKWRYESGKPGSNLTMTIVFR 235
Cdd:PRK10819  159 GPRALSRNQPQYPARAQALRIEGQVKVKFDVDEDGRVDNVRILSAEPRNMFEREVKQAMRKWRYEAGKPGKGLVVNIVFK 238


                  ....*...
gi 1799545454 236 INGGTSME 243
Cdd:PRK10819  239 INGTTEIE 246
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 169-237 1.34e-15

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 69.25  E-value: 1.34e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1799545454 169 ARAFALRIEGRVRVQYDVDSDGRVDNIRILSAQPRNMFERDVKQAMRKWRYES-----GKPGSNLTMTIVFRIN 237
Cdd:TIGR01352   1 ARARRRGIEGTVVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRKARFEPppppgGVVAASVTIPVRFKLP 74
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
 165-236 2.63e-15

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 68.46  E-value: 2.63e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799545454 165 PAYPARAFALRIEGRVRVQYDVDSDGRVDNIRILSAQPRNMFERDVKQAMRKWRYESGKPGSN-----LTMTIVFRI 236
Cdd:pfam03544   3 PVYPEEARRRGIEGTVVVEFLIDPDGNVTNVRVVKSSGYSILDEAALEAVKKWRFKPAPKNGQpvtveITVPIRFKL 79
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 168-233 1.34e-12

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 61.06  E-value: 1.34e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454 168 PARAFALRIEGRVRVQYDVDSDGRVDNIRILSAQPRNMFERDVKQAMRKWRYE----SGKPGSNLTMTIV 233
Cdd:COG0810     1 PEEARRRGIEGTVTVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRRWRFKpakqNGKPVRVKTVPIR 70
myxo_SS_tail NF033768
AgmX/PglI C-terminal domain; The AgmX/PglI C-terminal domain described by this HMM ...
 176-235 7.13e-04

AgmX/PglI C-terminal domain; The AgmX/PglI C-terminal domain described by this HMM (myxo_SS_tail) occurs as the C-terminal domain in multiple proteins per genome for a number of species capable of surface gliding motility, e.g. 12 in Myxococcus xanthus. Member proteins include the adventurous gliding motility proteins AgmX (GltJ) and PglI in M. xanthus. The domain is about 92 amino acids long, and features a pair of Cys residues about 45 amino acids apart in almost all cases.


Pssm-ID: 468180  Cd Length: 92  Bit Score: 37.55  E-value: 7.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1799545454 176 IEGRVRVQYDVDSDGRVDNIRILSAQPRNM-FERDVKQAMRKWRYESGKPGS-NLTMTIVFR 235
Cdd:NF033768   31 LAGKVVVEFTIGPSGRVSSVKVVSSTLKDPkVESCILRRIKRWRFPKPKGGEvTVTYPFIFS 92
TonB_N pfam16031
TonB polyproline region; TonB from Escherichia coli and its homologs are critical for the ...
 36-161 3.04e-03

TonB polyproline region; TonB from Escherichia coli and its homologs are critical for the uptake of siderophores through the outer membrane of Gram-negative bacteria using chemiosmotic energy. The proline-rich segment of TonB exists in a PPII-like conformation. The result implies that the proline-rich segment of TonB possesses a length of more than 15 nm, sufficient to span the periplasm of Gram-negative bacteria.


Pssm-ID: 435086 [Multi-domain]  Cd Length: 136  Bit Score: 36.92  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799545454  36 HQVIEAPKTSQ-PISVSLVAPEVQPEPQSAPPQAAPEPQPEPEPE------PVPEPPKPEPVAIPKPKPKPKPKPVKKEV 108
Cdd:pfam16031   1 HQVIELPSPAQqPISVTMVNPADLEPPPPAAPAPQPAPEPVVEPEpepepePLPEPPAPVVIHKPKPKPKPKPKPKPVKK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1799545454 109 VKPRK-EVKPhTEPRQASPFDND-NPLSASARPSTAPTRSSAPSRSIS--TGPRALS 161
Cdd:pfam16031  81 VEVPKrEVKP-VEPRPESPFENApSALVAPARPVSSTATAATASPSVSsaSGPRALS 136
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 14-62 7.63e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 37.13  E-value: 7.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1799545454  14 IPVLLSVVLHGSVIAALLYTSFHQVIEAPKT-------SQPISVSLVAPEVQPEPQ 62
Cdd:TIGR02794   2 RAFLLSLLLHILLLGLLILGSLYHSVKPEPGggaeiiqAVLVDPGAVAQQANRIQQ 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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